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4. sj-pdf-1-jcb-10.1177_0271678X231154602 - Supplemental material for Endothelial cell CD36 mediates stroke-induced brain injury via BBB dysfunction and monocyte infiltration in normal and obese conditions

Author

Kim, Il-doo, Ju, Hyunwoo, Minkler, Joseph, Jiang, Roselyn, Singh, Abhilasha, Sharma, Roopa, Febbraio, Maria, and Cho, Sunghee

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231154602 for Endothelial cell CD36 mediates stroke-induced brain injury via BBB dysfunction and monocyte infiltration in normal and obese conditions by Il-doo Kim, Hyunwoo Ju, Joseph Minkler, Roselyn Jiang, Abhilasha Singh, Roopa Sharma, Maria Febbraio, Sunghee Cho in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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10. The Effects of Sleep Hygiene Program on Sleep Quality in the Elderly Women

Author

Ju HyunWoo and Se JinJu

Subjects
Gerontology, Sleep disorder, Multidisciplinary, Sleep hygiene, Sleep quality, business.industry, Quality of sleep, Significant difference, 02 engineering and technology, medicine.disease, Pittsburgh Sleep Quality Index, 030507 speech-language pathology & audiology, 03 medical and health sciences, Family member, 0202 electrical engineering, electronic engineering, information engineering, medicine, 020201 artificial intelligence & image processing, Statistical analysis, 0305 other medical science, business
Abstract

Objectives: This research was tried to investigate effects of implementation of sleep hygiene education to elderly women people living in some local communities on Pittsburgh sleep quality index, sleep hygiene knowledge and depression of elderly women. Methods/Statistical Analysis: This study used quasi-experimental study design. Eligible participants were female seniors aged 60 or older living in a local community. A total of 50 participants were assigned to an 8-session sleep hygiene program (n=25) or control group (n=25). The collected data materials were processed with SPSS 18.0 program. Descriptive statistical method χ 2 test, t-test, and Paired t-test were utilized. The outcome variables were sleep quality, depression, and sleep hygiene education. Findings: The findings showed that the program was effective in decreasing sleep disorder. This study experimental group and control group were tested for their homogeneity. As a result, the two groups showed no statistically significant difference in their family member cohabitation status and number of physical illnesses whereas their age and educational background showed significant difference. The homogeneity between experiment and control groups was tested before the experiment regarding the dependent variables of sleep quality and depression. And the sleep quality in experiment group was found at 12.8; and control group, 11.16, representing a significant gap (t=2.52, p=.02). The depression status of experiment group was found at 4.56; and control group, 4.88, showing no significant gap (t=-.27, p=.79). Through the result of impact of sleep hygiene program on sleep quality in the elderly women, Pittsburgh sleep disorder score in participation group was much lower than in non-participation group (t=2.34, p

Published
2016

12. Seasonal proteomic plasticity in the brain of a mammalian hibernator

Author

Yoo, Woojae, Lee, Kisoo, Gwag, Taesik, Ju, Hyunwoo, Choi, Inho, and Yamashita, Masamichi

Subjects
Downregulation and upregulation, Biochemistry, General Medicine, Metabolism, Torpor, Biology, Biliverdin reductase B, Proteomics, Fusion protein, Neuroprotection, Hsp70
Abstract

Accepted: 2009-03-21, 資料番号: SA1000770000

Published
2008

15. Behavioral hypothermia of a domesticated lizard under treatment of the hypometabolic agent 3-iodothyronamine.

Author

Ha K, Shin H, Ju H, Chung CM, and Choi I

Subjects
Animals, Animals, Domestic, Energy Metabolism drug effects, Mice, Oxygen Consumption drug effects, Temperature, Behavior, Animal physiology, Body Temperature Regulation drug effects, Body Temperature Regulation physiology, Hypothermia, Lizards metabolism, Lizards physiology, Thyronines pharmacology
Abstract

Ectothermic animals rely on behavioral thermoregulation due to low capacity of heat production and storage. Previously, lizards were shown to achieve 'fever' during microbial infection by increasing their preferred body temperature (PBT) behaviorally, thereby attaining a relatively high survival rate. The purpose of this study was to investigate whether domesticated lizards pursued 'behavioral hypothermia' induced by a hypometabolic agent 3-iodothyronamine (T1AM). We found that treatment with 8.0 mg/kg T1AM caused a lizard species, the leopard gecko (Eublepharis macularius), to decrease its ventilation and oxygen consumption rates 0.64- and 0.76-fold, respectively, compared to those of the control (P<0.05). The lizards, habituated at an ambient temperature of 30 ± 0.5°C, also showed a significant decrease in the PBT range over a freely accessible thermal gradient between 5°C and 45°C. The upper limit of the PBT in the treated lizards lowered from 31.9°C to 30.6°C, and the lower limit from 29.5°C to 26.3°C (P<0.001). These findings demonstrate that the treated lizards pursued behavioral hypothermia in conjunction with hypoventilation and hypometabolism. Because prior studies reported a similar hypometabolic response in T1AM-injected laboratory mice, the domesticated lizards, as a part of the vertebrate phylogeny, may be a useful laboratory model for biological and pharmacological researches such as drug potency test.

Published
2017
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