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6. Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease

Author

Yun, Hae-Ryong, Joo, Young Su, Kim, Hyung Woo, Park, Jung Tak, Chang, Tae Ik, Son, Nak-Hoon, Yoo, Tae-Hyun, Kang, Shin-Wook, Sung, Suah, Lee, Kyu-Beck, Lee, Joongyub, Oh, Kook-Hwan, Han, Seung Hyeok, Ahn, Curie, Oh, Kook-Hwan, Han, Seung Seok, Lee, Hajeong, Koh, Young Ok, So, Jeongok, Ko, Seonui, Lee, Aram, Chae, Dong Wan, Jeong, Jong Cheol, Cho, Hyun Jin, Oh, Jung Eun, Lee, Kyu Jin, Yoo, Tae-Hyun, Choi, Kyu Hun, Han, Seung Hyeok, Park, Jung Tak, Hong, Hui Kyung, You, Ji Young, Lee, Kyu-Beck, Hyun, Young Youl, Kim, Hyun Jung, Kim, Yong-Soo, Kim, Yaeni, Kim, Sol Ji, Chung, Wookyung, Jung, Ji Yong, Jin, Kwon Eun, Sung, Suah, Min, Hyang Ki, Ku, Ja Yung, Kim, Soo Wan, Kwon, Seong, Bae, Eun Hui, Kim, Chang Seong, Kim, Ha Yeon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Minah, Myeong, Chana, Lee, Jeong Ho, Lee, Ji Seon, Kim, Yeong Hoon, Kang, Sun Woo, Kim, Tae Hee, Kim, Yunmi, Oh, Young Eun, Koo, Ja Ryong, Seo, Jang Won, Baek, Seon Ha, Kim, Myung Sun, Chang, Tae Ik, Park, Kyoung Sook, Choi, Aei Kyung, Oh, Yun Kyu, Lee, Jung Pyo, Lee, Jeong Hwan, Park, Jeong Mi, Seong, Eun Young, Heon, Song Sang, Rhee, Harin, Kim, Hyo Jin, Woon, Kim Da, Ji, Seung Hee, Kim, Young Taek, Na, Ki Ryang, Choi, Dae Eun, Ham, Young Rok, Lee, Eu Jin, and Cha, Yoon Jung

Published
2022
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8. Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?

Author

Kim, Hyoungnae, primary, Hyun, Young Youl, additional, Joo, Young Su, additional, Yun, Hae-Ryong, additional, Kim, Yaeni, additional, Jung, Ji Yong, additional, Jeong, Jong Cheol, additional, Kim, Jayoun, additional, Park, Jung Tak, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2023
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13. Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD

Author

Jung, Chan-Young, primary, Yun, Hae-Ryong, additional, Park, Jung Tak, additional, Joo, Young Su, additional, Kim, Hyung Woo, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Lee, Joongyub, additional, Chae, Dong-Wan, additional, Chung, Wookyung, additional, Kim, Yong-Soo, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2022
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14. Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD.

Author

Jung, Chan-Young, Yun, Hae-Ryong, Park, Jung Tak, Joo, Young Su, Kim, Hyung Woo, Yoo, Tae-Hyun, Kang, Shin-Wook, Lee, Joongyub, Chae, Dong-Wan, Chung, Wookyung, Kim, Yong-Soo, Oh, Kook-Hwan, and Han, Seung Hyeok

Subjects
CORONARY artery calcification, CHRONIC kidney failure, CARDIOVASCULAR disease related mortality, CHRONICALLY ill, MAJOR adverse cardiovascular events
Abstract

Background In East Asian countries, patients with chronic kidney disease (CKD) have lower cardiovascular risk profiles and experience fewer cardiovascular events (CVEs) than those in Western countries. Thus the clinical predictive performance of well-known risk factors warrants further testing in this population. Methods The KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) is a multicenter, prospective observational study. We included 1579 participants with CKD G1–G5 without kidney replacement therapy between 2011 and 2016. The main predictor was the coronary artery calcium score (CACS). The primary outcome was a composite of nonfatal CVEs or all-cause mortality. Secondary outcomes included 3-point major adverse cardiovascular events (MACEs; the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke), all CVEs and all-cause mortality. Results During a median follow-up of 5.1 years, a total of 123 primary outcome events occurred (incidence rate 1.6/100 person-years). In the multivariable Cox model, a 1-standard deviation log increase in the CACS was associated with a 1.67-fold [95% confidence interval (CI), 1.37–2.04] higher risk of the primary outcome. Compared with a CACS of 0, the hazard ratio associated with a CACS >400 was 4.89 (95% CI 2.68–8.93) for the primary outcome. This association was consistent for secondary outcomes. Moreover, inclusion of the CACS led to modest improvements in prediction indices of the primary outcome compared with well-known conventional risk factors. Conclusions In Korean patients with CKD, the CACS was independently associated with adverse cardiovascular outcomes and all-cause death. The CACS also showed modest improvements in prediction performance over conventional cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Synergic association of diabetes mellitus and chronic kidney disease with muscle loss and cachexia: results of a 16-year longitudinal follow-up of a community-based prospective cohort study

Author

Lee, Changhyun, primary, Kim, Hyun Jung, additional, Chang, Tae Ik, additional, Kang, Ea Wha, additional, Joo, Young Su, additional, Kim, Hyung Woo, additional, Park, Jung Tak, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Han, Seung Hyeok, additional

Published
2021
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20. Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study

Author

Lee, Jee Young, primary, Park, Jung Tak, additional, Joo, Young Su, additional, Lee, Changhyun, additional, Yun, Hae-Ryong, additional, Chang, Tae Ik, additional, Kim, Yeong-Hoon, additional, Chung, WooKyung, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Park, Sue K, additional, Chae, Dong Wan, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2021
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21. Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study.

Author

Lee, Jee Young, Park, Jung Tak, Joo, Young Su, Lee, Changhyun, Yun, Hae-Ryong, Chang, Tae Ik, Kim, Yeong-Hoon, Chung, WooKyung, Yoo, Tae-Hyun, Kang, Shin-Wook, Park, Sue K, Chae, Dong Wan, Oh, Kook-Hwan, and Han, Seung Hyeok

Subjects
BLOOD pressure, STATISTICAL models, CHRONIC kidney failure, KOREANS, CHRONICALLY ill
Abstract

Background Optimal blood pressure (BP) control is a major therapeutic strategy to reduce adverse cardiovascular events (CVEs) and mortality in patients with chronic kidney disease (CKD). We studied the association of BP with adverse cardiovascular outcome and all-cause death in patients with CKD. Methods Among 2238 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD), 2226 patients with baseline BP measurements were enrolled. The main predictor was systolic BP (SBP) categorized by five levels: <110, 110–119, 120–129, 130–139 and ≥140 mmHg. The primary endpoint was a composite outcome of all-cause death or incident CVEs. We primarily used marginal structural models (MSMs) using averaged and the most recent time-updated SBPs. Results During the follow-up of 10 233.79 person-years (median 4.60 years), the primary composite outcome occurred in 240 (10.8%) participants, with a corresponding incidence rate of 23.5 [95% confidence interval (CI) 20.7–26.6]/1000 patient-years. MSMs with averaged SBP showed a U-shaped relationship with the primary outcome. Compared with time-updated SBP of 110–119 mmHg, hazard ratios (95% CI) for <110, 120–129, 130–139 and ≥140 mmHg were 2.47 (1.48–4.11), 1.29 (0.80–2.08), 2.15 (1.26–3.69) and 2.19 (1.19–4.01), respectively. MSMs with the most recent SBP also showed similar findings. Conclusions In Korean patients with CKD, there was a U-shaped association of SBP with the risk of adverse clinical outcomes. Our findings highlight the importance of BP control and suggest a potential hazard of SBP <110 mmHg. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Smoking Cessation and Coronary Artery Calcification in CKD

Author

Lee, Mi Jung, primary, Park, Jung Tak, additional, Chang, Tae Ik, additional, Joo, Young Su, additional, Yoo, Tae-Hyun, additional, Park, Sue Kyung, additional, Chung, Wookyung, additional, Kim, Yong-Soo, additional, Kim, Soo Wan, additional, Oh, Kook-Hwan, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, and Han, Seung Hyeok, additional

Published
2021
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23. Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW-CKD.

Author

Cheol Ho Park, Hyung Woo Kim, Young Su Joo, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue Kyung Park, Dong-Wan Chae, Wookyung Chung, Yong-Soo Kim, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han, Park, Cheol Ho, Kim, Hyung Woo, Joo, Young Su, Park, Jung Tak, Chang, Tae Ik, Yoo, Tae-Hyun, and Park, Sue Kyung

Published
2022
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25. Low High‐Sensitivity C‐Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW‐CKD

Author

Lee, Changhyun, primary, Park, Keun Hyung, additional, Joo, Young Su, additional, Nam, Ki Heon, additional, Chang, Tae‐Ik, additional, Kang, Ea Wha, additional, Lee, Joongyub, additional, Oh, Yun Kyu, additional, Jung, Ji Yong, additional, Ahn, Curie, additional, Lee, Kyu‐Beck, additional, Park, Jung Tak, additional, Yoo, Tae‐Hyun, additional, Kang, Shin‐Wook, additional, and Han, Seung Hyeok, additional

Published
2020
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29. P0926ASSOCIATION OF HIGH-SENSITIVE C-REACTIVE PROTEIN WITH CARDIOVASCULAR EVENTS, MORTALITY, AND ADVERSE KIDNEY OUTCOMES IN KOREAN PATIENTS WITH CHRONIC KIDNEY DISEASE: RESULTS FROM KNOW-CKD

Author

Lee, Changhyun, primary, Park, Keun Hyung, primary, Joo, Young Su, primary, Nam, Ki Heon, primary, Chang, Tae-Ik, primary, Kang, Ea Wha, primary, Lee, Joongyub, primary, Oh, Yun Kyu, primary, Jung, Ji Yong, primary, Ahn, Curie, primary, Lee, Kyu-Beck, primary, Park, Jung Tak, primary, Yoo, Tae-Hyun, primary, Kang, Shin-Wook, primary, and Han, Seung Hyeok, primary

Published
2020
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30. Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease

Author

Jhee, Jong Hyun, primary, Joo, Young Su, additional, Park, Jung Tak, additional, Yoo, Tae-Hyun, additional, Park, Sue Kyung, additional, Jung, Ji Yong, additional, Kim, Soo Wan, additional, Oh, Yun Kyu, additional, Oh, Kook-Hwan, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, and Han, Seung Hyeok, additional

Published
2020
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32. Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease

Author

Joo, Young Su, primary, Koh, Heebyung, additional, Nam, Ki Heon, additional, Lee, Sangmi, additional, Kim, Joohwan, additional, Lee, Changhyun, additional, Yun, Hae-Ryong, additional, Park, Jung Tak, additional, Kang, Ea Wha, additional, Chang, Tae Ik, additional, Yoo, Tae-Hyun, additional, Oh, Kook-Hwan, additional, Chae, Dong Wan, additional, Lee, Kyu-Beck, additional, Kim, Soo Wan, additional, Lee, Joongyub, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, and Han, Seung Hyeok, additional

Published
2020
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33. Urinary chloride concentration and progression of chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease

Author

Joo, Young Su, primary, Kim, Jinseok, additional, Park, Cheol Ho, additional, Yun, Hae-Ryong, additional, Park, Jung Tak, additional, Chang, Tae Ik, additional, Yoo, Tae-Hyun, additional, Sung, Su-Ah, additional, Lee, Joongyub, additional, Oh, Kook-Hwan, additional, Kim, Soo Wan, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, and Han, Seung Hyeok, additional

Published
2019
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34. Body weight fluctuation is associated with rapid kidney function decline.

Author

Joo, Young Su, Nam, Ki Heon, Jhee, Jong Hyun, Yun, Hae‐Ryong, Lee, Sangmi, Han, Seung Hyeok, Yoo, Tae‐Hyun, Kang, Shin‐Wook, and Park, Jung Tak

Subjects
KIDNEY physiology, BODY weight, GLOMERULAR filtration rate, EPIDERMAL growth factor receptors
Abstract

Objective: This study aimed to evaluate the effects of body weight fluctuations on kidney function deterioration in a prospective cohort of individuals with normal kidney function. Methods: Data were obtained from the Korean Genome and Epidemiology Study. Body weight fluctuations were determined using average successive variability (ASV), which was defined as the average absolute body weight change using repeated measurements for all participants. The decline of the estimated glomerular filtration rate (eGFR) over time was calculated using linear regression analysis of serial eGFR measurements for each patient. Rapid eGFR decline was defined as an average eGFR decline > 3 mL/min/1.73 m2 per year. Results: A total of 6,790 participants were analyzed. During a median follow‐up of 11.7 years, rapid eGFR decline was observed in 913 (13.4%) participants. When the participants were categorized into tertiles according to ASV, rapid eGFR decline was more prevalent in the highest ASV tertile group than in the lowest. Analyses using multiple logistic regression models revealed that the risk of rapid eGFR decline was increased in the highest ASV tertile group compared with the lowest (odds ratio: 1.66). Conclusions: Body weight fluctuations were significantly associated with an increased risk of rapid kidney function decline in participants with normal kidney function. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Snoring and incident chronic kidney disease: a community-based prospective cohort study

Author

Lee, Changhyun, primary, Joo, Young Su, additional, Lee, Sangmi, additional, Kang, Shinchan, additional, Kim, Joohwan, additional, Nam, Ki Heon, additional, Yun, Hae-Ryong, additional, Jhee, Jong Hyun, additional, Kim, Hyoungnae, additional, Han, Seung Hyeok, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Park, Jung Tak, additional

Published
2019
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47. Secondhand Smoke and CKD

Author

Jhee, Jong Hyun, primary, Joo, Young Su, additional, Kee, Youn Kyung, additional, Jung, Su-Young, additional, Park, Seohyun, additional, Yoon, Chang-Yun, additional, Han, Seung Hyeok, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Park, Jung Tak, additional

Published
2019
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48. Incidence of Acute Kidney Injury after Adrenalectomy in Patients with Primary Aldosteronism

Author

Lee, Jee Young, primary, Kim, Hyoungnae, additional, Kim, Hyung Woo, additional, Ryu, Geun Woo, additional, Nam, Yooju, additional, Lee, Seonyeong, additional, Joo, Young Su, additional, Lee, Sangmi, additional, Park, Jung Tak, additional, Han, Seung Hyeok, additional, Kang, Shin-Wook, additional, Yoo, Tae-Hyun, additional, and Yun, Hae-Ryong, additional

Published
2019
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49. Urinary chloride concentration and progression of chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease.

Author

Joo, Young Su, Kim, Jinseok, Park, Cheol Ho, Yun, Hae-Ryong, Park, Jung Tak, Chang, Tae Ik, Yoo, Tae-Hyun, Sung, Su-Ah, Lee, Joongyub, Oh, Kook-Hwan, Kim, Soo Wan, Kang, Shin-Wook, Choi, Kyu Hun, Ahn, Curie, and Han, Seung Hyeok

Subjects
*CHRONIC kidney failure, *CHRONICALLY ill, *KIDNEY tubules, *CHLORIDES, *COHORT analysis
Abstract

Background Urinary chloride is regulated by kidney transport channels, and high urinary chloride concentration in the distal tubules can trigger tubuloglomerular feedback. However, little attention has been paid to urinary chloride as a biomarker of clinical outcomes. Here, we studied the relationship between urinary chloride concentration and chronic kidney disease (CKD) progression. Methods We included 2086 participants with CKD from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease. Patients were categorized into three groups, according to baseline urinary chloride concentration tertiles. The study endpoint was a composite of ≥50% decrease in estimated glomerular filtration rate from baseline values, or end-stage kidney disease. Results During a median follow-up period of 3.4 years (7452 person-years), 565 participants reached the primary endpoint. There was a higher rate of CKD progression events in the lowest and middle tertiles than in the highest tertile. Compared with the lowest tertile, the highest tertile was associated with 33% [95% confidence interval (CI) 0.49–0.90] lower risk for the primary outcome in a cause-specific hazard model after adjustment for confounding variables. In addition, for every 25 mEq/L increase in urinary chloride concentration, there was 11% (95% CI 0.83–0.96) lower risk for CKD progression. This association was consistent in a time-varying model. Urinary chloride concentration correlated well with tubule function and kidney injury markers, and its predictive performance for CKD progression was comparable to that of these markers. Conclusions In this hypothesis-generating study, low urinary chloride concentration was associated with a higher risk for CKD progression. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Low High-Sensitivity C-Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW-CKD.

Author

Changhyun Lee, Keun Hyung Park, Young Su Joo, Ki Heon Nam, Tae-Ik Chang, Ea Wha Kang, Joongyub Lee, Yun Kyu Oh, Ji Yong Jung, Curie Ahn, Kyu-Beck Lee, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han, Lee, Changhyun, Park, Keun Hyung, Joo, Young Su, Nam, Ki Heon, and Chang, Tae-Ik

Published
2020
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