Search

Androgen receptor (AR) drives prostate cancer (PC) growth and progression, and targeting AR signaling is the mainstay of pharmacological therapies for PC. Resistance develops relatively fast as a result of refueled AR activity. A major gap in the field is the lack of understanding of targetable mechanisms that induce persistent AR expression in castrate-resistant PC (CRPC). This study uncovers an unexpected function of active Stat5 signaling, a known promoter of PC growth and clinical progression, as a potent inducer of AR gene transcription. Stat5 suppression inhibited AR gene transcription in preclinical PC models and reduced the levels of wild-type, mutated, and truncated AR proteins. Pharmacological Stat5 inhibition by a specific small-molecule Stat5 inhibitor down-regulated Stat5-inducible genes as well as AR and AR-regulated genes and suppressed PC growth. This work introduces the concept of Stat5 as an inducer of AR gene transcription in PC. Pharmacological Stat5 inhibitors may represent a new strategy for suppressing AR and CRPC growth.

We examined development of 5- and 10.5-month-old infants' face representations, focusing on infants' discrimination and categorization of female and male faces. We tested for gender-based preferences and categorization of female and male faces by presenting infants with pairs of faces and then habituating them to a series of majority female or male face ensembles. We then tested for gender preferences with new face pairs (one female and one male; Study 1) or new face ensembles (majority female and majority male; Study 2). We found that both 5- and 10.5-month-old infants discriminated female from male faces in face pairs, and both age groups looked more at female faces during habituation. Neither age group, however, provided evidence of gender-based categorization. We interpret these findings within a theoretical framework that stresses environmental exposure to different social categories, and infants' ability to detect commonalities of features within categories. We conclude that infants' gender-based categorization of faces is constrained by the set of features available in the input.

Mental rotation (MR) is the ability to transform a mental representation of an object so as to accurately predict how the object would look from a different angle (Sci 171:701-703, 1971), and it is involved in a number of important cognitive and behavioral activities. In this review we discuss recent studies that have examined MR in infants and the development of MR across the first year after birth. These studies have produced many conflicting results, yet several tentative conclusions can be reached. First, MR may be operational in infants as young as 3 months of age. Second, there may be sex differences in MR performance in infancy, in general favoring males, as there are in children and in adults. Third, there appear to be multiple influences on infants' MR performance, including infants' motor activity, stimulus or task complexity, hormones, and parental attitudes. We conclude by calling for additional research to examine more carefully the causes and consequences of MR abilities early in life.

Academic buoyancy (AB) is the ability to overcome minor academic setbacks. However, although it seems as though teachers would be well placed to comment on this characteristic in students, no teacher-report measure of AB exists. This study evaluates a teacher-report version of the widely used, student-report, Academic Buoyancy Scale (ABS). Confirmatory factor analysis supported the unifactorial nature of the Teacher Academic Buoyancy Scale (TABS), and the scale showed excellent internal reliability. However, while there was some evidence for the criterion-related validity of the TABS, it showed very poor convergent validity with the ABS. It also correlated better with academic achievement than should theoretically be the case for a measure of AB. Further, AB estimates from the two measures were moderated by demographic characteristics: teachers rated girls and those not facing adversity as more buoyant, but the opposite was the case for self-reports. In sum, this study suggests a significant disjunction between teacher- and self-reports of AB, and that teacher estimates of AB are likely to be affected by salient, non-AB-related, student characteristics.

Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically important phenomenon and (b) examining methodological, cultural, and developmental moderators. We focus on infants’ preference for infant-directed speech (IDS) over adult-directed speech (ADS). Stimuli of mothers speaking to their infants and to an adult in North American English were created using seminaturalistic laboratory-based audio recordings. Infants’ relative preference for IDS and ADS was assessed across 67 laboratories in North America, Europe, Australia, and Asia using the three common methods for measuring infants’ discrimination (head-turn preference, central fixation, and eye tracking). The overall meta-analytic effect size (Cohen’s d) was 0.35, 95% confidence interval = [0.29, 0.42], which was reliably above zero but smaller than the meta-analytic mean computed from previous literature (0.67). The IDS preference was significantly stronger in older children, in those children for whom the stimuli matched their native language and dialect, and in data from labs using the head-turn preference procedure. Together, these findings replicate the IDS preference but suggest that its magnitude is modulated by development, native-language experience, and testing procedure.

Diminished attention to socially relevant information appears to be an early emerging risk factor associated with autism spectrum disorders (ASD). However, inconsistencies across studies suggest that atypicalities in visual social attention in infants at high-risk for ASD during the first postnatal year may be subtle and more apparent under certain contexts. Here we explore factors that may moderate developmental trajectories in attention to faces, including the social complexity of the dynamic visual stimuli used to measure visual social attention and the early social environment of the infant as indexed by parental affectedness of ASD-related traits. Across infants at both high (HR) and low risk for ASD, attention to faces increased during the first postnatal year, with overall greater attention being allocated to schematic faces in the simpler video stimulus. Moreover, greater parental affectedness of ASD-related traits was associated with reduced developmental gains in attention to faces. For HR infants, greater attention to faces was positively associated with social communicative competence, including better joint attention skills and lower social impairments. Altogether, our findings highlight the importance of considering developmental level when selecting stimuli to longitudinally examine visual social attention, and the clinical relevance of including measures of infant's social environment in understanding early markers of ASD risk. Autism Res 2019, 12: 445-457 © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Attention to faces is an important means for infants to learn about the social world. The complexity of the social scene and an infant's early social environment both affect the amount of time infants at high- and low-risk for ASD look at faces during the first postnatal year. For infants at high-risk for ASD, greater attention to faces was associated with better social skills. Understanding an infant's social environment may have a positive impact on social communicative development.

Mental rotation (MR) is an important feature of spatial cognition invoking mental imagery of an object's appearance when viewed from a new orientation. Prior studies have revealed evidence of MR in infants, including a sex difference similar to that detected in older populations. Some of these studies used visual habituation methods whereby infants were familiarized with an object rotating through a 240° angle, followed by test trials showing either the habituation object or a mirror image object rotating through the previously unseen 120° angle. Significantly longer looking at either of these objects was taken to reflect infants' ability to recognize the habituation object even when seen from a novel viewpoint, suggesting the capacity for MR. However, these infants' responses could, in theory, be explained with reference to perceptual discrimination rather than MR, because the views of the habituation and test objects were very similar in some video frames. In the current study, we observed a diverse population of 5-month-olds (24 females, 24 males) for evidence of MR through 30° of arc. In this more challenging test, our stimuli left a 30° gap angle between critical video frames representing the habituation and test objects. Consistent with earlier reports, we found that relative to female infants, male infants looked significantly longer at the mirror image test stimulus immediately following habituation. These results add to an emerging consensus that some young infants are capable of MR, and that male and female infants on average behave differently in this type of MR task. [ABSTRACT FROM AUTHOR]

We asked whether 11- and 14- month-old infants' abstract rule learning, an early form of analogical reasoning, is susceptible to processing constraints imposed by limits in attention and memory for sequence position. We examined 11- and 14- month-old infants' learning and generalization of abstract repetition rules ("repetition anywhere," Experiment 1 or "medial repetition," Experiment 2) and ordering of specific items (edge positions, Experiment 3) in 4-item sequences. Infants were habituated to sequences containing repetition- and/or position-based structure and then tested with "familiar" vs. "novel" (random) sequences composed of new items. Eleven-month-olds (N = 40) failed to learn abstract repetition rules, but 14-month-olds (N = 40) learned rules under both conditions. In Experiment 3, 11-month-olds (N = 20) learned item edge positions in sequences identical to those in Experiment 2. We conclude that infant sequence learning is constrained by item position in similar ways as in adults.

We examined mechanisms underlying infants' ability to categorize human biological motion stimuli from sex-typed walk motions, focusing on how visual attention to dynamic information in point-light displays (PLDs) contributes to infants' social category formation. We tested for categorization of PLDs produced by women and men by habituating infants to a series of female or male walk motions and then recording posthabituation preferences for new PLDs from the familiar or novel category (Experiment 1). We also tested for intrinsic preferences for female or male walk motions (Experiment 2). We found that infant boys were better able to categorize PLDs than were girls and that male PLDs were preferred overall. Neither of these effects was found to change with development across the observed age range (∼4-18 months). We conclude that infants' categorization of walk motions in PLDs is constrained by intrinsic preferences for higher motion speeds and higher spans of motion and, relatedly, by differences in walk motions produced by men and women.

Compared to monolinguals, bilingual children attend more to pragmatic cues, especially when they conflict with perceptualcues (Brojde et al., 2012). This longitudinal eye-tracking study investigated monolingual and bilingual two-year-olds (T1M age=24.3 months; T2 M age=27.6 months) visual attention in a word learning paradigm containing a conflict betweeneye gaze (pragmatic cue) and object salience (perceptual cue). Participants saw videos of a model looked looking at andlabeling either a salient or a nonsalient object. Next, participants saw the objects from the videos side-by-side onscreen, andheard either the target label or a novel distracter label. At T1, monolinguals (N=14) and bilinguals (N=10) showed similarlooking patterns during learning; at test, bilinguals modulated their looking to target and distracter objects differently thanmonolinguals. At T2, monolinguals and bilinguals showed similar looking patterns during all trials. These results suggestthat language background may differentially influence word learning and visual attention across development.

We recorded visual attention to same- and other-race faces in Hispanic and White 11-month-old infants, an age at which face processing is presumably biased by an own-race recognition advantage. Infants viewed pairs of faces differing in race or ethnicity as their eye movements were recorded. We discovered consistently greater attention to Black over Hispanic faces, to Black faces over White faces, and to Hispanic over White faces. Inversion of face stimuli, and infant ethnicity, had little effect on performance. Infants' social environments, however, differed sharply according to ethnicity: Hispanic infants are almost exclusively exposed to Hispanic family members, and White infants to White family members. Moreover, Hispanic infants inhabit communities that are more racially and ethnically diverse. These results imply that race-based visual attention in infancy is closely aligned with the larger society's racial and ethnic composition, as opposed to race-based recognition, which is more closely aligned with infants' immediate social environments.

We examined mechanisms underlying infants’ ability todetect, extract, and generalize sequential patterns, focusing onhow saliency and consistency of distributional informationguide infant learning of the most “likely” pattern inaudiovisual sequences. In Experiment 1, we asked if 11- and14-month-old infants could learn a “repetition anywhere” rule(e.g., ABBC, AABC, ABCC). In Experiment 2 we asked if11- and 14-month-olds could generalize a “medial repetition”rule when its position is consistent in sequence, and inExperiment 3 we asked if 11-month-olds could identify anonadjacent dependency occurring at edge positions. Infantswere first habituated to 4-item sequences (shapes + syllables)containing repetition- and/or position-based structure, andwere then tested with “familiar” structure instantiated acrossnew items or combinations of items vs. “novel” (random)sequences. We found that 11-month-olds failed to learn therepetition rule both when the structure appeared in initial,medial, or final position (Experiment 1) and when it wasrestricted to the medial position (Experiment 2). Fourteen-month-olds learned repetition rules under both conditions.Finally, in Experiment 3 11-month-olds succeeded in learninga nonadjacent dependency in sequences identical to thoseused to test repetition learning in Experiment 2. Our resultssuggest that infants at 11 months, like adults, are relativelyinsensitive to patterns in the middle of sequences.

Developing understanding of fractions involves connections between nonsymbolic visual representations and symbolic representations. Initially, teachers introduce fraction concepts with visual representations before moving to symbolic representations. Once the focus is shifted to symbolic representations, the connections between visual representations and symbolic notation are considered to be less useful, and students are rarely asked to connect symbolic notation back to visual representations. In 2 experiments, we ask whether visual representations affect understanding of symbolic notation for adults who understand symbolic notation. In a conceptual fraction comparison task (e.g., Which is larger, 5 / a or 8 / a?), participants were given comparisons paired with accurate, helpful visual representations, misleading visual representations, or no visual representations. The results show that even college students perform significantly better when accurate visuals are provided over misleading or no visuals. Further, eye-tracking data suggest that these visual representations may affect performance even when only briefly looked at. Implications for theories of fraction understanding and education are discussed.

Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5-9 years, of younger siblings of children with ASD (high-risk group, n = 79) or typical development (low-risk group, n = 60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632-642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

A cognitive construct that is important when solving engineering design problems is executive control process, or metacognition. It is a central feature of human consciousness that enables one "to be aware of, monitor, and control mental processes." The framework for this study was conceptualized by integrating the model for creative design, which illustrates the co-evolution of the problem and solution spaces during engineering design problem solving, with executive control processes such as planning, monitoring, and evaluation. According to Maher, Poon, and Boulanger (1996), whenever engineers are solving design problems, their problem and solution spaces co-evolve with an interchange of information between the two mental spaces. This study investigates if there are differences in the cognitive process of mechanical engineering students and professional mechanical engineers as they use executive control processes (i.e., planning, monitoring, and evaluation) in the problem and solution spaces while solving an engineering design problem conceptually. The findings from this qualitative study confirm previous findings of other studies and provide useful insights about the executive control processes of student and professional mechanical engineer designers. Three conclusions were drawn from the findings: (1) That expert planning and monitoring is driven by propositions, while the novice planning and monitoring is influenced by analogical comparisons; (2) That mental representations are used mostly when the engineering student and professional engineers are monitoring their design solutions, and the professional engineers are more balanced than the students in their use of analogies and propositions; and (3) That evaluation plays a larger role in the solution space of professional engineers, while engineering students do more planning in the problem space. The findings indicate that the engineering students did more planning than the professional engineers. (Contains 4 figures and 2 tables.)

This study investigated the mental representations of student and professional engineers while they solved an engineering design problem. The intent was to gain a deeper insight into the differences that exist in the cognitive processes of engineering students and professional engineers as they use mental representations (i.e., propositions, metaphors, and analogies) to solve the engineering design problem. A comparative case study of engineering students and practicing engineers was conducted. A purposeful, maximum variation sampling process was used. Maximum variation sampling, a special type of purposeful sampling, entails the "selecting of cases that illustrate the range of variation in the phenomena to be studied". The results of this study paint a picture of how four professional engineers differ from six engineering students in their use of mental representations on a conceptual engineering design task. Three major conclusions are drawn from the findings: (1) The use of mental representations, such as propositions, analogies, and metaphors, in the different mental spaces is important in engineering design; (2) Different from novices, experts rarely employed propositions or analogies in their problem space; and (3) Expert engineering designers differ from novice engineering designers on their use of within-domain analogies, between-domain analogies, heuristics, and formulas. (Contains 8 figures and 1 table.)

BackgroundWe evaluated early pragmatic language skills in preschool-age siblings of children with autism spectrum disorder (ASD), and examined correspondence between pragmatic language impairments and general language difficulties, autism symptomatology, and clinical outcomes.MethodsParticipants were younger siblings of children with ASD (high-risk, n = 188) or typical development (low-risk, n = 119) who were part of a prospective study of infants at risk for ASD; siblings without ASD outcomes were included in analyses. Pragmatic language skills were measured via the Language Use Inventory (LUI).ResultsAt 36 months, the high-risk group had significantly lower parent-rated pragmatic language scores than the low-risk group. When defining pragmatic language impairment (PLI) as scores below the 10(th) percentile on the LUI, 35% of the high-risk group was identified with PLI versus 10% of the low-risk group. Children with PLI had higher rates of general language impairment (16%), defined as scores below the 10(th) percentile on the Receptive or Expressive Language subscales of the Mullen Scales of Early Learning, relative to those without PLI (3%), but most did not evidence general language impairments. Children with PLI had significantly higher ADOS scores than those without PLI and had higher rates of clinician-rated atypical clinical best estimate outcomes (49%) relative to those without PLI (15%).ConclusionsPragmatic language problems are present in some siblings of children with ASD as early as 36 months of age. As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as they get older. Close monitoring of early pragmatic language development in young children at familial risk for ASD is warranted.

Much research has documented learners’ ability to segment auditory and visual input into its component units. Two types of models have been designed to account for this phenomena: statistical models, in which learners represent statistical relations between elements, and chunking models, in which learners represent statistically coherent units of information. In a series of three experiments, we investigated how adults’ performance on a visual sequence-learning task aligned with the predictions of these two types of models. Experiments 1 and 2 examined learning of embedded items and Experiment 3 examined learning of illusory items. The pattern of results obtained was most consistent with the competitive chunking model of Servan-Schreiber and Anderson (1990). Implications for theories and models of statistical learning are discussed.

Statistical learning is characterized by detection of regularities in one's environment without an awareness or intention to learn, and it may play a critical role in language and social behavior. Accordingly, in this study we investigated the electrophysiological correlates of visual statistical learning in young children with autism spectrum disorder (ASD) using an event-related potential shape learning paradigm, and we examined the relation between visual statistical learning and cognitive function. Compared to typically developing (TD) controls, the ASD group as a whole showed reduced evidence of learning as defined by N1 (early visual discrimination) and P300 (attention to novelty) components. Upon further analysis, in the ASD group there was a positive correlation between N1 amplitude difference and non-verbal IQ, and a positive correlation between P300 amplitude difference and adaptive social function. Children with ASD and a high non-verbal IQ and high adaptive social function demonstrated a distinctive pattern of learning. This is the first study to identify electrophysiological markers of visual statistical learning in children with ASD. Through this work we have demonstrated heterogeneity in statistical learning in ASD that maps onto non-verbal cognition and adaptive social function.

Although there are many reasons why students dropout of college courses, those reasons may be unique for students who are enrolled in an online program. Issues of isolation, disconnectedness, and technological problems may be factors that influence a student to leave a course. To understand these factors, an online survey was developed to collect data from students who dropped out of an online program. Logistic regression analysis was used to compare various factors between those who persist in the program and those who dropout. The results, based on the dropouts from three cohorts in an online graduate program, show that demographic variables do not predict likelihood of dropping from a program. Instead, the students' reasons for dropping out of an online program are varied and unique to each individual. Recommendations for further study are incorporated in the conclusions. (Contains 1 figure and 6 tables.)

The integration of online technologies in educational practice is rendering new opportunities for teaching and learning. It is known that instructors who have taught fully online courses have acquired new skills and have had the opportunity to implement novel pedagogical practices in the online environment. However, it is unclear whether direct exposure to fully online teaching facilitates the integration of technology in traditional classrooms. This qualitative investigation examined the transfer of four experienced faculty members' pedagogical practices from online to face-to-face teaching. Results of this case study show that (a) the instructors' online teaching experience influenced their perceptions and understanding of online pedagogical strategies, and (b) the transfer of pedagogical strategies back to the classroom is a complex process influenced by the instructors' teaching style, satisfaction with working in the online environment, and the similarity of content and context between online and face-to-face courses. These findings have the potential to inform innovations in faculty training and development and to promote further research in this area. (Contains 1 figure and 2 tables.)

This article features the University Council for Workforce and Human Resource Education, a nonprofit organization representing leading United States universities that offer graduate programs in career and technical education (CTE) and human resource development (HRD). The mission of the Council is to be a recognized force in shaping the future of CTE and HRD through improving the policy and practices of education in the United States toward the betterment of individuals and the larger society. The universities represented by UCWHRE are considered world leaders in the area of workforce development and human resource education. While they are natural competitors for students and external funding, they have traditionally worked closely together for over 30 years to collectively develop the next generation of leaders that are prepared to solve problems related to achieving a professional, productive, and competent workforce. The authors discuss the history, purpose and activities of the University Council for Workforce and Human Resource Education.

ObjectiveYounger siblings of children with autism spectrum disorder (ASD) are at high risk (HR) for developing ASD as well as features of the broader autism phenotype. Although this complicates early diagnostic considerations in this cohort, it also provides an opportunity to examine patterns of behavior associated specifically with ASD compared to other developmental outcomes.MethodWe applied Classification and Regression Trees (CART) analysis to individual items of the Autism Diagnostic Observation Schedule (ADOS) in 719 HR siblings to identify behavioral features at 18 months that were predictive of diagnostic outcomes (ASD, atypical development, and typical development) at 36 months.ResultsThree distinct combinations of features at 18 months were predictive of ASD outcome: poor eye contact combined with lack of communicative gestures and giving; poor eye contact combined with a lack of imaginative play; and lack of giving and presence of repetitive behaviors, but with intact eye contact. These 18-month behavioral profiles predicted ASD versus non-ASD status at 36 months with 82.7% accuracy in an initial test sample and 77.3% accuracy in a validation sample. Clinical features at age 3 years among children with ASD varied as a function of their 18-month symptom profiles. Children with ASD who were misclassified at 18 months were higher functioning, and their autism symptoms increased between 18 and 36 months.ConclusionThese findings suggest the presence of different developmental pathways to ASD in HR siblings. Understanding such pathways will provide clearer targets for neural and genetic research and identification of developmentally specific treatments for ASD.

The focus of research in technology education has evolved throughout its history as the field changed from industrial arts to technology education (Spencer & Rogers, 2006). With the move to technology education, the field has begun to broaden its focus to better understand the teaching, learning, curriculum, and policy implications of preparing the next generation of technological thinkers. Although a complete "paradigm shift" may not have occurred completely within all technology-oriented programs (Sanders, 2001), the current emphasis on engineering within technology education indicates a need to examine and assess the status of technology education research over the past 10 years to identify strengths and areas that need to be addressed in order to guide the field into the future. The purpose of this study was to assess the quality and characteristics of the research that has been published within the field of technology education between 1997 and 2007. More specifically, this study was designed to determine the types of research conducted within the technology education field, including the research focus, methods, primary data sources, and data types. The following questions were explored to accomplish this purpose: (1) What types of research have been conducted in technology education over the past 10 years?; (2) What research methods have been most commonly used in technology education research over the past 10 years?; and (3) What types of people and data have been the focus of research in technology education over the past 10 years? A driving motivation for this study was to explore the extent to which technology education research conforms to Shavelson and Towne's (2002) "guiding principles" of scientific inquiry, and to gauge the alignment of technology education research with the current national trend toward a "gold standard" for educational research methods. Answers to these questions provide insight into the degree to which recent technology education research aligns with the "gold standard" for educational research. (Contains 6 tables.)

ObjectiveThis study had 3 goals, which were to examine the following: the frequency of atypical development, consistent with the broader autism phenotype, in high-risk infant siblings of children with autism spectrum disorder (ASD); the age at which atypical development is first evident; and which developmental domains are affected.MethodA prospective longitudinal design was used to compare 294 high-risk infants and 116 low-risk infants. Participants were tested at 6, 12, 18, 24, and 36 months of age. At the final visit, outcome was classified as ASD, Typical Development (TD), or Non-TD (defined as elevated Autism Diagnostic Observation Schedule [ADOS] score, low Mullen Scale scores, or both).ResultsOf the high-risk group, 28% were classified as Non-TD at 36 months of age. Growth curve models demonstrated that the Non-TD group could not be distinguished from the other groups at 6 months of age, but differed significantly from the Low-Risk TD group by 12 months on multiple measures. The Non-TD group demonstrated atypical development in cognitive, motor, language, and social domains, with differences particularly prominent in the social-communication domain.ConclusionsThese results demonstrate that features of atypical development, consistent with the broader autism phenotype, are detectable by the first birthday and affect development in multiple domains. This highlights the necessity for close developmental surveillance of infant siblings of children with ASD, along with implementation of appropriate interventions as needed.

Viral entry targets with therapeutic neutralizing potential are subject to multiple escape mechanisms, including antigenic drift, immune dominance of functionally irrelevant epitopes, and subtle variations in host cell mechanisms. A surprising finding of recent years is that potent neutralizing antibodies to viral epitopes independent of strain exist, but are poorly represented across the diverse human population. Identifying these antibodies and understanding the biology mediating the specific immune response is thus difficult. An effective strategy for meeting this challenge is to incorporate multiplexed antigen screening into a high throughput survey of the memory B cell repertoire from immune individuals. We used this approach to discover suites of cross-clade antibodies directed to conformational epitopes in the stalk region of the influenza A hemagglutinin (HA) protein and to select high-affinity anti-peptide antibodies to the glycoprotein B (gB) of human cytomegalovirus. In each case, our screens revealed a restricted VH and VL germline usage, including published and previously unidentified gene families. The in vivo evolution of paratope specificity with optimal neutralizing activity was understandable after correlating biological activities with kinetic binding and epitope recognition. Iterative feedback between antigen probe design based on structure and function information with high throughput multiplexed screening demonstrated a generally applicable strategy for efficient identification of safe, native, finely tuned antibodies with the potential for high genetic barriers to viral escape.

Visual attention and perception develop rapidly during the first few months after birth, and these behaviors are critical components in the development of language and cognitive abilities. Here we ask how early bilingual experiences might lead to differences in visual attention and perception. Experiments 1-3 investigated the looking behavior of monolingual and bilingual infants when presented with social (Experiment 1), mixed (Experiment 2), or non-social (Experiment 3) stimuli. In each of these experiments, infants' dwell times (DT) and number of fixations to areas of interest (AOIs) were analyzed, giving a sense of where the infants looked. To examine how the infants looked at the stimuli in a more global sense, Experiment 4 combined and analyzed the saccade data collected in Experiments 1-3. There were no significant differences between monolingual and bilingual infants' DTs, AOI fixations, or saccade characteristics (specifically, frequency, and amplitude) in any of the experiments. These results suggest that monolingual and bilingual infants process their visual environments similarly, supporting the idea that the substantial cognitive differences between monolinguals and bilinguals in early childhood are more related to active vocabulary production than perception of the environment.

The article focuses on exploring Justice David Hackett Souter's stance on the right to privacy, especially concerning controversial issues like abortion and euthanasia. It discusses Souter's judicial behavior in privacy cases, noting his failure to consistently align with the conservative agenda due to his respect for the law and the Court's reputation as a neutral arbiter of the Constitution.