1. Factors associated with cardiovascular events after simultaneous liver-kidney transplant from the US Multicenter Simultaneous Liver-Kidney Transplant Consortium.
- Author
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Jo, Jennifer, Crespo, Gonzalo, Gregory, Dyanna, Sinha, Jasmine, Xie, Jiaheng, Zhang, Min, Magee, John, Barman, Pranab, Patel, Yuval A, Schluger, Aaron, Walters, Kara, Biggins, Scott, Filipek, Natalia, Cullaro, Giuseppe, Wong, Randi, Lai, Jennifer C, Perreault, Gabriel J, Verna, Elizabeth C, Sharma, Pratima, and VanWagner, Lisa B
- Subjects
Liver ,Humans ,Cardiovascular Diseases ,Kidney Transplantation ,Liver Transplantation ,Retrospective Studies ,Adult ,Female ,Male ,Digestive Diseases ,Organ Transplantation ,Aging ,Transplantation ,Kidney Disease ,Liver Disease ,Cardiovascular ,Heart Disease ,Atherosclerosis ,Clinical Research ,Renal and urogenital ,Good Health and Well Being - Abstract
Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver-kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network for Organ Sharing regions in the US Multicenter SLKT Consortium. The primary outcome was a CVE defined as hospitalization due to acute coronary syndrome, arrhythmia, congestive heart failure, or other CV causes (stroke or peripheral vascular disease) within 1 year of SLKT. Among 515 SLKT subjects (mean age ± SD, 55.4 ± 10.6 years; 35.5% women; 68.1% White), 8.7% had a CVE within 1 year of SLKT. The prevalence of a CVE increased from 3.3% in 2002-2008 to 8.9% in 2009-2011 to 14.0% in 2012-2017 ( p = 0.0005). SLKT recipients with a CVE were older (59.9 vs. 54.9 years, p
- Published
- 2023