36 results on '"Jiang-Tao Zhang"'
Search Results
2. IRF2BPL gene variants with dystonia: one new Chinese case report
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Fei Yang, Hui Li, Yi Dai, Ran Zhang, and Jiang-tao Zhang
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Dystonia ,Dysarthria ,IRF2BPL mutation ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background The carriers of damaging heterozygous variants in interferon regulatory factor 2 binding protein-like (IRF2BPL), encoding a member of the IRF2BP family of transcriptional regulators, may be affected by a variety of neurological symptoms, such as neurodevelopmental regression, language and motor developmental delay, seizures, progressive ataxia and a lack of coordination, and even dystonia. Case presentation We report a Chinese boy who presented with dystonia, dysarthria, and normal development due to nonsense IRF2BPL mutation, with intact imaging and EEG findings but without developmental delays or seizures. Whole-exome sequencing revealed a novel nonsense variant IRF2BPL (NM_024496) Exon C.562C > T (p.Arg188*). Conclusion This case report presents a Chinese boy with a novel nonsense variant in IRF2BPL, displaying rapid progressive dystonia and dysarthria, without early developmental delay or epilepsy; expands the IRF2BPL phenotypes in the Chinese population; and raises awareness of patients with IRF2BPL.
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- 2023
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3. Factors Influencing Copulation Duration in Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae)
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Hui-Hui Zhong, Chao-Qun Li, Jiang-Tao Zhang, Li-Feng Wei, and Xing-Ping Liu
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copulation duration ,physiological factors ,ecological factors ,reproductive outputs ,Dastarcus helophoroides (Fairmaire) ,Science - Abstract
The gregarious ectoparasitic beetle Dastarcus helophoroides (Fairmaire) is considered a primary biocontrol agent for controlling several cerambycid pests in East Asian countries. A thorough study of reproductive behavior is a prerequisite for the mass production of natural insect predators. Nonetheless, little attention has been given to this ectoparasitic beetle. We performed a series of trials to assess whether the adult copulation duration, a key behavioral trait, is differentially influenced by physiological and ecological factors, including body size, mating history, kinship, sex ratio, mating sequence, feeding status, ambient temperature, photoperiod, and time of day. Additionally, the effect of the copulation duration on the reproductive output of this beetle was also investigated. The results indicated that the copulation duration varied considerably, ranging from 1.12 min to 16.40 min and lasting for an average of 9.11 ± 0.12 min. Females with longer copulations laid more eggs and had a greater proportion of eggs hatched. Medium-sized individuals copulated significantly longer than small- and large-sized individuals. The copulation durations were significantly longer when both sexes experienced an asymmetric mating history than when both sexes experienced a symmetric mating history. Inbred couples copulated significantly longer than outbred couples. In terms of the adult sex ratio, increasing the density of females (polygamous group) or males (polyandrous group) led to significantly longer copulation durations than those in the monogamous group. The copulation durations gradually decreased with increasing the mating sequence and temperature. Food-absence couples copulated significantly longer than food-presence couples. The mean copulation duration of the scotophase was significantly longer than that of the photophase. These results demonstrate that all of the analyzed factors emerge as important factors influencing the copulation duration, ultimately affecting the reproductive outputs in this ectoparasitic beetle.
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- 2024
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4. Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice
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Guo-Kun Zhou, Wen-Jing Xu, Yi Lu, Yan Zhou, Chen-Zhang Feng, Jiang-Tao Zhang, Shi-Yu Sun, Ruo-Meng Wang, Tong Liu, and Bin Wu
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itch ,agmatine ,ASIC3 ,atopic dermatitis ,pain ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
IntroductionItch is a common symptom of many skin and systemic diseases. Identifying novel endogenous itch mediators and the downstream signaling pathways involved will contribute to the development of new strategies for the treatment of chronic itch. In the present study, we adopted behavioral testing, patch clamp recording and metabonomics analysis to investigate the role of agmatine in itch and the underlying mechanism.MethodsBehavioral analysis was used to evaluate the establishing of acute and chronic itch mice model, and to test the effects of different drugs or agents on mice itch behavior. Western blotting analysis was used to test the effect of agmatine on phosphorylation of ERK (p-ERK) expression in the spinal cord. Patch clamp recording was used to determine the effect agmatine on the excitability of DRG neurons and the role of ASIC3. Finally, the metabonomics analysis was performed to detect the concentration of agmatine in the affected skin under atopic dermatitis or psoriasis conditions.ResultsWe fused a mouse model and found that an intradermal injection of agmatine (an endogenous polyamine) into the nape of the neck or cheek induced histamine-independent scratching behavior in a dose-dependent manner. In addition, the ablation of nociceptive C-fibers by resiniferatoxin (RTX) abolished agmatine-induced scratching behavior. However, agmatine-induced itch was not affected by the pharmacological inhibition of either transient receptor potential vanilloid 1 (TRPV1) or transient receptor potential ankyrin 1 (TRPA1); similar results were obtained from TRPV1−/− or TRPA1−/− mice. Furthermore, agmatine-induced itch was significantly suppressed by the administration of acid-sensing ion channel 3 (ASIC3) inhibitors, APETx2 or amiloride. Agmatine also induced the upregulation of p-ERK in the spinal cord; this effect was inhibited by amiloride. Current clamp recording showed that the acute perfusion of agmatine reduced the rheobase and increased the number of evoked action potentials in acute dissociated dorsal root ganglion (DRG) neurons while amiloride reversed agmatine-induced neuronal hyperexcitability. Finally, we identified significantly higher levels of agmatine in the affected skin of a mouse model of atopic dermatitis (AD) when compared to controls, and the scratching behavior of AD mice was significantly attenuated by blocking ASIC3.DiscussionCollectively, these results provide evidence that agmatine is a novel mediator of itch and induces itch via the activation of ASIC3. Targeting neuronal ASIC3 signaling may represent a novel strategy for the treatment of itch.
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- 2023
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5. Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice
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Cun-Jin Su, Jiang-Tao Zhang, Feng-Lun Zhao, De-Lai Xu, Jie Pan, and Tong Liu
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RvD1 ,paclitaxel ,FPR2 ,Il-10 ,macrophage ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionPaclitaxel is a chemotherapy drug that is commonly used to treat cancer, but it can cause paclitaxel-induced neuropathic pain (PINP) as a side effect. Resolvin D1 (RvD1) has been shown to be effective in promoting the resolution of inflammation and chronic pain. In this study, we evaluated the effects of RvD1 on PINP and its underlying mechanisms in mice.MethodsBehavioral analysis was used to assess the establishment of the PINP mouse model and to test the effects of RvD1 or other formulations on mouse pain behavior. Quantitative real-time polymerase chain reaction analysis was employed to detect the impact of RvD1 on 12/15 Lox, FPR2, and neuroinflammation in PTX-induced DRG neurons. Western blot analysis was used to examine the effects of RvD1 on FPR2, Nrf2, and HO-1 expression in DRG induced by PTX. TUNEL staining was used to detect the apoptosis of DRG neurons induced by BMDM conditioned medium. H2DCF-DA staining was used to detect the reactive oxygen species level of DRG neurons in the presence of PTX or RvD1+PTX treated BMDMs CM.ResultsExpression of 12/15-Lox was decreased in the sciatic nerve and DRG of mice with PINP, suggesting a potential involvement of RvD1 in the resolution of PINP. Intraperitoneal injection of RvD1 promoted pain resolution of PINP in mice. Intrathecal injection of PTX-treated BMDMs induced mechanical pain hypersensitivity in naïve mice, while pretreatment of RvD1 in BMDMs prevented it. Macrophage infiltration increased in the DRGs of PINP mice, but it was not affected by RvD1 treatment. RvD1 increased IL-10 expression in the DRGs and macrophages, while IL-10 neutralizing antibody abolished the analgesic effect of RvD1 on PINP. The effects of RvD1 in promoting IL-10 production were also inhibited by N-formyl peptide receptor 2 (FPR2) antagonist. The primary cultured DRG neurons apoptosis increased after stimulation with condition medium of PTX-treated BMDMs, but decreased after pretreatment with RvD1 in BMDMs. Finally, Nrf2-HO1 signaling was additionally activated in DRG neurons after stimulation with condition medium of RvD1+PTX-treated BMDMs, but these effects were abolished by FPR2 blocker or IL-10 neutralizing antibody.DiscussionIn conclusion, this study provides evidence that RvD1 may be a potential therapeutic strategy for the clinical treatment of PINP. RvD1/FPR2 upregulates IL-10 in macrophages under PINP condition, and then IL-10 activates the Nrf2- HO1 pathway in DRG neurons, relieve neuronal damage and PINP.
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- 2023
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6. Neuroprognostication value of serum neurofilament light chain for out-of-hospital cardiac arrest: A systematic review and meta-analysis.
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Yu Fu, Xiao-Tian Fan, Hui Li, Ran Zhang, Ding-Ding Zhang, Hao Jiang, Zhi-Guo Chen, and Jiang-Tao Zhang
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Medicine ,Science - Abstract
BackgroundNeurofilament light chain (NfL) is a novel biomarker for the assessment of neurological function after cardiac arrest (CA). Although meta-analysis has confirmed its predictive value, it has not conducted a more detailed analysis of its research. We conducted a meta-analysis to evaluate the relationship between serum NfL level and neurological prognosis in patients with spontaneous circulation recovery after CA, and subgroup analysis was conducted according to sample collection time, time to assess neurological function, study design, whether TTM was received, the method of specimen determination, and the presence of neurological disease in patients. To analyze the influence of these factors on the predictive value of serum NfL.MethodsPublished Cochrane reviews and an updated, extended search of MEDLINE, Cochrane Library, Embase, Scopus, ClinicalKey, CINAHL, and Web of Science for relevant studies until March 2022 were assessed through inclusion and exclusion criteria. The standard mean difference and 95% confidence interval were calculated using the random-effects model or fixed-effects model to assess the association between one variable factor NfL level and the outcome of CA patients. Subgroup analysis according to sample collection time was performed. The prognosis analysis and publication bias were also assessed using Egger's and Begg's tests.ResultsAmong 1209 related articles for screening, 6 studies (1360 patients) met the inclusion criteria and were selected for meta-analysis. The level of serum NfL in the good prognosis group (CPC1-2, CPC: cerebral performance category score) was significantly lower than that in the poor prognosis group (CPC3-5)SMD(standardized mean difference) = 0.553, 95%CI(confidence interval) = 0.418-0.687, I2 = 65.5% PConclusionNfL may play a potential neuroprognostication role in postcardiac arrest patients with spontaneous circulation, regardless of when the sample was collected after CA.
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- 2023
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7. Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice
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Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, and Tong Liu
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ganciclovir ,colitis ,microbiome ,STING ,macrophage ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Ganciclovir (GCV) is a prodrug nucleoside analogue and is clinically used as antiviral drug for the treatment of cytomegalovirus (CMV) and other infections. Based on the potential anti-inflammatory activity of GCV, this study aimed to investigate the therapeutic effects of ganciclovir on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC), which may involve cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathways. Our results demonstrated that incubation of GCV (50 μM) inhibited cGAS-STING pathway in macrophage RAW264.7 cells. Then, it was found that intestinal cGAS-STING pathways were upregulated in UC patients, Crohn’s disease colitis (CD) patients, and DSS-induced colitis mice. Intraperitoneal injection of low-dose GCV (10 mg/kg/day) attenuated DSS-induced colitis and abdominal pain in mice. GCV treatment significantly inhibited the upregulation of cGAS-STING pathway in DSS-induced colitis mice. Moreover, DSS-induced colitis and gut dysbiosis was markedly attenuated in STING deficient mice compared with that of wild-type (WT) mice. Finally, there was lacking therapeutic effect of GCV on DSS-induced colitis in STING deficient mice. Together, our results indicated that low-dose GCV ameliorated DSS-induced UC in mice, possibly through inhibiting STING signaling in colonic macrophages, indicating that GCV may be useful for the treatment of UC.
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- 2022
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8. Antioxidant properties and inhibition of angiotensin-converting enzyme by highly active peptides from wheat gluten
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Wen-Ying Liu, Jiang-Tao Zhang, Takuya Miyakawa, Guo-Ming Li, Rui-Zeng Gu, and Masaru Tanokura
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Medicine ,Science - Abstract
Abstract This study aimed to focus on the high-value utilization of raw wheat gluten by determining the potent antioxidant peptides and angiotensin I-converting enzyme (ACE) inhibitory peptides from wheat gluten oligopeptides (WOP). WOP were analyzed for in vitro antioxidant activity and inhibition of ACE, and the identification of active peptides was performed by reversed-phase high-performance liquid chromatography and mass spectrometry. Quantitative analysis was performed for highly active peptides. Five potent antioxidant peptides, Leu-Tyr, Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr and Arg-Gly-Gly-Tyr (6.07 ± 0.38, 7.28 ± 0.29, 11.18 ± 1.02, 5.93 ± 0.20 and 9.04 ± 0.47 mmol 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) equivalent/g sample, respectively), and five potent ACE inhibitory peptides, Leu-Tyr, Leu-Val-Ser, Tyr-Gln, Ala-Pro-Ser-Tyr and Arg-Gly-Gly-Tyr (half maximal inhibitory concentration (IC50) values = 0.31 ± 0.02, 0.60 ± 0.03, 2.00 ± 0.13, 1.47 ± 0.08 and 1.48 ± 0.11 mmol/L, respectively), were observed. The contents of Leu-Tyr, Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr, Arg-Gly-Gly-Tyr, and Leu-Val-Ser were 155.04 ± 8.36, 2.08 ± 0.12, 1.95 ± 0.06, 22.70 ± 1.35, 0.25 ± 0.01, and 53.01 ± 2.73 μg/g, respectively, in the WOP. Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr, Arg-Gly-Gly-Tyr, and Leu-Val-Ser are novel antioxidative/ACE inhibitory peptides that have not been previously reported. The results suggest that WOP could potentially be applied in the food industry as a functional additive.
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- 2021
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9. A new Atrococcus species (Hemiptera, Coccomorpha, Pseudococcidae) from China, with a key to Chinese species
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Jiang-Tao Zhang, Jia-Ying Zhou, You-Liang Pan, and Xing-Ping Liu
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Zoology ,QL1-991 - Abstract
A new mealybug species Atrococcus rushuiensis Zhang, sp. nov., collected under the leaf sheath of Sporobolus fertilis (Poaceae) in Fuzhou City, Jiangxi Province, China, is described and illustrated. A new combination is introduced, transferring Allotrionymus shanxiensis Wu to the genus Atrococcus as A. shanxiensis (Wu), comb. nov. A key is presented for the species of Atrococcus recorded from China.
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- 2020
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10. The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice
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Yue Hu, Qing-Yue Fu, Dan-Ni Fu, Xue-Long Wang, Zhi-Hong Wang, Jiang-Tao Zhang, Wen-Jing Xu, Guo-Kun Zhou, Li-Hua Chen, and Tong Liu
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Itch ,Zn2+ ,TRPA1 ,GPR39 ,p-ERK ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Itching is a common symptom of many skin or systemic diseases and has a negative impact on the quality of life. Zinc, one of the most important trace elements in an organism, plays an important role in the regulation of pain. Whether and how zinc regulates itching is largely unclear. Herein, we explored the role of Zn2+ in the regulation of acute and chronic itch in mice. It is found that intradermal injection (i.d.) of Zn2+ dose-dependently induced acute itch and transient receptor potential A1 (TRPA1) participated in Zn2+-induced acute itch in mice. Moreover, the pharmacological analysis showed the involvement of histamine, mast cells, opioid receptors, and capsaicin-sensitive C-fibers in Zn2+-induced acute itch in mice. Systemic administration of Zn2+ chelators, such as N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), pyrithione, and clioquinol were able to attenuate both acute itch and dry skin-induced chronic itch in mice. Quantitative polymerase chain reaction (Q-PCR) analysis showed that the messenger RNA (mRNA) expression levels of zinc transporters (ZIPs and ZnTs) significantly changed in the dorsal root ganglia (DRG) under dry skin-induced chronic itch condition in mice. Activation of extracellular signal-regulated kinase (ERK) pathway was induced in the DRG and skin by the administration of zinc or under dry skin condition, which was inhibited by systemic administration of Zn2+ chelators. Finally, we found that the expression of GPR39 (a zinc-sensing GPCR) was significantly upregulated in the dry skin mice model and involved in the pathogenesis of chronic itch. Together, these results indicated that the TRPA1/GPR39/ERK axis mediated the zinc-induced itch and, thus, targeting zinc signaling may be a promising strategy for anti-itch therapy.
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- 2022
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11. Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice
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Xu Liu, Jiang-Tao Zhang, Yue Hu, Wen-Qi Shan, Zhi-Hong Wang, Qing-Yue Fu, Dan-Ni Fu, Jiang Ji, and Tong Liu
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itch ,pain ,formalin ,TRPA1 ,dorsal root ganglion ,Medicine (General) ,R5-920 - Abstract
Chronic itch is a common distressing symptom of many diseases, which reduced patient's quality of life. The mechanistic study on itch and screening for new anti-itch drugs require the development of new pre-clinical itch animal models. Herein, we established an acute itch model by intradermal (i.d.) injection of low-dose formalin into the neck or cheek in mice. In mice, i.d. injection of formalin (0.1–5%) in the nape of the neck evoked robust scratching behavior in a dose-dependent manner and the dose–response curves showed an inverted “U” shape. I.d. injection of formalin (0.3–0.6%) into the cheek evoked scratching in mice but wiping in rats, while formalin (1.25–5%) induced mixed wiping and scratching behavior in both mice and rats. Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice. Additionally, 0.3% formalin-induced up-regulation of phosphorylation of extracellular regulated protein kinases (p-ERK) in the dorsal root ganglion (DRG) and scratching were suppressed by intrathecal injection of MEK inhibitor U0126 in mice. Incubation of 0.03% formalin induced the accumulation of intracellular reactive oxygen species (ROS) in the cultured DRG-derived cell line ND7-23, and formalin-induced itch was suppressed by antioxidants in mice. Finally, perfusion of 0.03% formalin induced elevation of intracellular calcium in a subset of primary cultured DRG neurons of mice. Thus, these results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.
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- 2021
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12. Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective
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Li Zhang, Jiang-Tao Zhang, Lihua Hang, and Tong Liu
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pain ,opioid ,opioid receptor ,heterodimer ,side effect ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic tolerance, hyperalgesia, high addictive potential, and abuse liability. Opioids exert their effects through binding to the opioid receptors belonging to the G-protein coupled receptors (GPCRs) family, including mu opioid receptor (MOR), delta opioid receptor (DOR), and kappa opioid receptor (KOR). Among them, MOR is essential for opioid-induced analgesia and also responsible for adverse effects of opioids. Importantly, MOR can form heterodimers with other opioid receptors and non-opioid receptors in vitro and in vivo, and has distinct pharmacological properties, different binding affinities for ligands, downstream signaling, and receptor trafficking. This mini review summarized recent progress on the function of Mu opioid receptor heterodimers, and we proposed that targeting mu opioid receptor heterodimers may represent an opportunity to develop new therapeutics, especially for chronic pain treatment.
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- 2020
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13. A study of the genus Paraputo Laing, 1929 of China, with description of two new species (Hemiptera, Sternorrhyncha, Coccomorpha)
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Jiang-Tao Zhang and San-An Wu
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Zoology ,QL1-991 - Abstract
A study of the genus Paraputo Laing, 1929 (Coccomorpha: Pseudococcidae) from China is provided. Eight Paraputo species are recognized in China, of which two species, P. platani sp. n. and P. yunnanensis sp. n., are described as new and P. banzigeri Williams, 2004 is recorded from China for the first time. Two new combinations are introduced, involving transfer of P. citricola Tang, 1992 and P. sinensis Borchsenius, 1962 to the genus Formicococcus Takahashi, 1928. A key to the Paraputo species of China is provided.
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- 2017
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14. Structure and composition of a potential antioxidant obtained from the chelation of pea oligopeptide and sodium selenite
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Xiu-Yuan Qin, Jiang-Tao Zhang, Guo-Ming Li, Ming Zhou, Rui-Zeng Gu, Jun Lu, and Wen-Ying Liu
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Pea ,Low-molecular-weight peptides ,Chelation ,Conformation changes ,Antioxidant activity ,Peptide fragment quantification ,Nutrition. Foods and food supply ,TX341-641 - Abstract
A selenium-chelating pea oligopeptide (Se-POP) was prepared from pea oligopeptide (POP) and sodium selenite (SS) via chelation. Se-POP is rich in organic selenium as 57.23% ± 0.36%. The chelation reaction was spontaneous and endothermic, with a binding constant Ka = 2.64 × 104 ± 1.60 × 103 M−1 and binding site number n = 0.27 ± 0.01. Spectral analysis indicated protein conformational changes consistent with chelation, that the peptide chain to fold and curl, causing random coil and β-turn decreasing and the peptide side-chain radicals folding and burying. The antioxidant capacity of Se-POP was increased relative to that of POP. One novel antioxidant peptide fragment was obtained from Se-POP and identified as PPKIYP, presenting at a concentration of 29.47 ng/mg. The results indicated that Se-POP might be a new organic Se supplement with antioxidant capacity, which may be easily absorbed due to its low molecular weight.
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- 2020
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15. Weakness and numbness of extremities with bowel and bladder dysfunction for four years
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Han-hui FU, Jiang-tao ZHANG, Qing LIU, and Li-ying CUI
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Neuromyelitis optica ,Lupus erythermatosus, systemic ,Case reports ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The patient was a 53-year-old female who was admitted for “numbness and weakness of lower extremities, urinary and defecation dysfunction for 4 years” in September 2016. Four years ago, the patient felt numbness and weakness of lower extremities, with chest zonesthesia and back pain. The weakness of left lower extremity got severer next morning and she cannot feel her left foot on the pedal when riding bicycle. At night, she presented numbness under umbilicus level, feet scuff and urine retention. She was also unable to squat. No fever, headache, vomiting or visual defect was found. She was treated as stroke which showed no effect. Two days later, the numbness extended to thoracic level with no sweating below, dyspnea, deep voice, bucking, dysphagia and weakness of both upper and lower extremities. Spinal MRI showed a long T1 signal and long T2 signal extended cervical cord lesion from C4-T5 segments and spinal cord swelling. She was suspected to have multiple sclerosis (MS) or neuromyelitis optica (NMO), thus prednisone was given that resulted in the improvement other than numbness of lower extremities, stagger and bladder dysfunction. In the following 4 years, alike symptoms relapsed every year. Though the glucocorticoid treatment was helpful for symptoms remission, sequelae including extremities numbness, weakness, stagger, urinary incontinence and intermittent constipation were left. The predisposing and relieving factors were unclear for relapse. Six months ago, the patient stopped the glucocorticoid treatment by herself, followed by the increase of attack frequencies. One month ago, she got diplopia in the right eye. The patient was admitted for further diagnosis and treatment. Since the onset of symptoms, the patient has been conscious. The appetite and defecation have been normal. No dryness of mouth and eye, shin rash, Reynolds Syndrome, photosensitization and joint pain was noticed. She has a weight loss of 5kg, during which time the weight increased apparently once because of the intake of glucocorticoid. Past history, personal history and family history: Her left eye lost sight because of cataracts secondary to repeated episodes of uveitis 30 years ago. She received thyroid hormone therapy for 6 years because of hypothyroidism and withdrew one year ago without the guidance of a doctor. Three years ago she was diagnosed with cataracts in the right eye and treated with pupilplasty+phaco+intraocular lens (IOL) implantation surgery. She also had severe vertebral compression fractures 2 years ago. Physical examination: T 36.7℃, R 19/min, BP 90/51mmHg (1mmHg=0.133kPa), SaO2 99%; The patient was thin and had a thoracic kyphosis malformation. No edema, ulcer or rash was found on her skin. She was awake, alert, and able to respond to commands. The left eye was blind and showed enophthalmos. Visual partially loss was detected in the right eye with normal visual field. Eye movements were normal without nystagmus. Muscle capacity decreased partially. The muscle strength was 4 of right upper limb, 5 of left upper limb, 3 of right lower limb and 4 of left lower limb. Muscle tone of right upper limb was high. The heel-to-knee tests of right side and Romberg test were not stable. She walked with spastic gait. The tendon reflexes of both upper and lower limbs were active. The Babinski and Chaddock signs of both sides were positive. Hypoesthesia was present in the right cheek. The pinprick, vibration and touch sensation lost partially below T4 level while only vibration sensation lost below T12 level. Investigations: The blood, urine and stool routine tests, biochemical tests, coagulation tests, HIV, hepatitis B and hepatitis C tests were all normal. The erythrocyte sedimentation rate (ESR) was 38mm/h (0-20mm/h); IgG 24.16g/L (7-17g/L), C3 0.62g/L (0.73-1.46g/L), C4 0.08g/L (0.1-0.4g/L), rheumatoid factor (RF) 158.20IU/ml (0-20IU/ml). The immunofixation electrophoresis was negative. Antinuclear antibody (ANA) 1:640 (<1:40), antineutrophilic cytoplasmic antibody (ANCA), antiphospholipid antibody were negative. DNA-immunofluorescence (IF) 1:10 (<1:5), DNS-enzyme-linked immunosorbent assay (ELISA) 296IU/ml (<100IU/ml); Tumor biomarkers screening showed no positive finding. Serum iron 8.243umol/L (8.59-30.43 umol/L), transferrin 18.06umol/L (22.72-40.90 umol/L), total iron binding capacity 41.35umol/L (44.75-80.55 umol/L), transferrin saturation 16.70% (25-50%). The cerebrospinal fluid (CSF) was clear. The routine, biochemistry and lactic acid of CSF were within normal range. Cytological examination was negative. AQP-4 antibody (also named NMO-IgG) in CSF was 1:100. No abnormal finding showed in the chest CT and cranial MRI. Thoracic spinal cord MRI showed a longitudinally extensive high intensity lesion on spinal cord of C7-T7 segments in sagittal T2WI and compression fractures of T7-10, especially T7-8. Labial salivary gland biopsy showed lymphocytes infiltration. Diagnosis and treatment: After admission, she was treated with vitamin B (vitamin B1 10mg 3 times/d and mecobalamine 0.5mg 3 times/d), ginkgo capsule 400mg 3 times/d and baclofen 5mg 3 times/d orally. She was diagnosed as neuromyelitis optica spectrum disorder (NMOSD), connective tissue disease (CTD), systemic lupus erythematosus (SLE) , secondary Sjögren’s Syndrome (SS). Thyroxine replacement therapy (levothyroxine sodium 50μg/d) and calcium supplements (calcium carbonate 500mg/d, calcitriol 0.3μg 2 times/d, alendronate sodium 70mg/week) and orthosis were taken according to the endocrinologists and orthopedists. She was treated with azathioprine (50mg/d) and methyprednisolone pulse therapy (500mg/d, intravenous drip) followed by oral methylprednisolone (50mg/d). The dose of methylprednisolone decreases by 5mg/d every two weeks. Two months later, the patients showed improvement in walking while no obvious change was noticed of other symptoms and signs. DOI: 10.3969/j.issn.1672-6731.2017.03.014
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- 2017
16. Progressive numbness and weakness of extremities for four years
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Yin-yan XU, Jiang-tao ZHANG, Jing-wen NIU, Jun NI, and Li-ying CUI
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Charcot-Marie-Tooth disease ,Diabetes mellitus ,Case reports ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Hereditary motor and sensory neuropathy (HMSN), also known as Charcot-Marie-Tooth (CMT), is a hereditary peripheral neuropathy characterized by progressive numbness and weakness of the extremities, atrophy and paresthesia, with genetic mutations in various associated genes such as PMP22, in most cases. Most CMT patients suffer from mild to moderate paresthesia, but only 20-30% of them complain of pain in the limbs. Diabetes mellitus also causes abnormal sensation in peripheral nerves and might arouse confusion in the diagnosis of CMT especially in those with comorbidity of diabetes. Here, we present a late onset case of a PMP22 heterozygote complicated with one year of type 2 diabetes mellitus, who has significant tingling in his fingers and toes. We also present a typical neural ultrasound image of a diffusedly thickened nerve of this patient in support of the diagnosis of CMT1. DOI: 10.3969/j.issn.1672-6731.2017.01.014
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- 2017
17. Numbness and weakness of limbs for 10 months
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Jiang-tao ZHANG, Wei ZHAO, Jun NI, Yi-cheng ZHU, Xiao-yan CHANG, and Li-ying CUI
- Subjects
Paraneoplastic polyneuropathy ,Ganglia, sensory ,Case reports ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
DOI: 10.3969/j.issn.1672-6731.2016.08.014
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- 2016
18. Headache, numbness and weakness of left limbs
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Qiong YANG, Jing YUAN, Jun NI, Zhen-hao ZHANG, Jiang-tao ZHANG, Yi-cheng ZHU, Bin PENG, and Li-ying CUI
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Vasospasm, intracranial ,Case reports ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
DOI: 10.3969/j.issn.1672-6731.2016.12.012
- Published
- 2016
19. Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord.
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Bing Wang, Li-Na Wang, Bin Wu, Ran Guo, Li Zhang, Jiang-Tao Zhang, Zhi-Hong Wang, Feng Wu, Yu Feng, Hong Liu, Xiao-Hong Jin, Xiu-Hua Miao, and Tong Liu
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- 2024
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20. Risk factors and prognosis of early neurological deterioration in patients with posterior circulation cerebral infarction
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Hui Li, Jiang-Tao Zhang, Yi Zheng, Ding- Ding Zhang, Xiu-Ying Cui, Xin Zhao, Guan-Wen Zhang, Fei Yang, Yu Fu, Xiao-Tian Fan, Hao Jiang, Jian-Ming Shi, Bo Wang, and Ran Zhang
- Subjects
Surgery ,Neurology (clinical) ,General Medicine - Abstract
Background: The incidence, risk factors, and pathogenesis of early neurological deterioration (END) in posterior circulation stroke are still unclear. In this study, we aimed to determine the risk factors and prognosis of END in patients with acute posterior circulation cerebral infarction. Methods: Acute posterior circulation ischemic stroke patients who had completed neuroimaging within 72 hours of onset were selected from a prospective registry study. Demographic characteristics, physiological data, medical history, laboratory data, in-hospital evaluation, neurological severity and TOAST classification, treatment, and the modified Rankin Scale (mRS) score of patients were assessed. Early neurological deterioration was defined as an increase of ≥2 points in the National Institutes of Health Stroke Scale score between the baseline and 72-hour evaluation. Favorable and poor outcomes were defined as mRSs of 0–2 and ≥3, respectively, at 3 months. The incidence and risk factors were evaluated by univariate and multivariate regression analysis (step-back method). Results: The analysis included 455 subjects with an acute posterior circulation non-cardiac ischemic stroke, 330 (72.53%) of them male, with an average age of 63.12 (±10.14) years and with 47 (10.33%) having END. The results of univariate and multivariate logistic regression analysis showed that BATMAN scores ≥5 (OR: 0.1, 95% CI: 0.02–0.53, P < 0.01), large artery atherosclerosis (OR: 11.55, 95% CI: 4.18–31.93, P < 0.01), vascular stenosis >50% (OR: 2.44, 95% CI: 1.1–5.42, P = 0.029), reperfusion therapy (OR: 4.21, 95% CI: 1.66–10.64, P < 0.01), and the distribution of pontine lesions (OR: 5.66, 95% CI: 2.39–13.44, P< 0.01) were significantly associated with END. Patients with END had a lower rate of favorable outcomes at discharge and long-term follow-up (P < 0.001), regardless of whether they received reperfusion therapy. Conclusion: The lesion distribution of the pons, the progression of temporo-occipital lobe lesions, and large arterial atherosclerosis are independent risk factors of END that might predict a poor short- and long-term prognosis.
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- 2022
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21. Antioxidant properties and inhibition of angiotensin-converting enzyme by highly active peptides from wheat gluten
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Takuya Miyakawa, Guo-Ming Li, Ruizeng Gu, Liu Wenying, Masaru Tanokura, and Jiang-Tao Zhang
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0301 basic medicine ,Angiotensins ,Antioxidant ,Glutens ,Biomaterials - proteins ,medicine.medical_treatment ,Science ,Angiotensin-Converting Enzyme Inhibitors ,Peptidyl-Dipeptidase A ,Antioxidants ,Mass Spectrometry ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,medicine ,Amino Acid Sequence ,IC50 ,Triticum ,chemistry.chemical_classification ,Oligopeptide ,030109 nutrition & dietetics ,Multidisciplinary ,biology ,Angiotensin-converting enzyme ,04 agricultural and veterinary sciences ,040401 food science ,Peptide Fragments ,In vitro ,Enzyme ,chemistry ,Biochemistry ,biology.protein ,Medicine ,Trolox ,Peptides ,Quantitative analysis (chemistry) - Abstract
This study aimed to focus on the high-value utilization of raw wheat gluten by determining the potent antioxidant peptides and angiotensin I-converting enzyme (ACE) inhibitory peptides from wheat gluten oligopeptides (WOP). WOP were analyzed for in vitro antioxidant activity and inhibition of ACE, and the identification of active peptides was performed by reversed-phase high-performance liquid chromatography and mass spectrometry. Quantitative analysis was performed for highly active peptides. Five potent antioxidant peptides, Leu-Tyr, Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr and Arg-Gly-Gly-Tyr (6.07 ± 0.38, 7.28 ± 0.29, 11.18 ± 1.02, 5.93 ± 0.20 and 9.04 ± 0.47 mmol 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) equivalent/g sample, respectively), and five potent ACE inhibitory peptides, Leu-Tyr, Leu-Val-Ser, Tyr-Gln, Ala-Pro-Ser-Tyr and Arg-Gly-Gly-Tyr (half maximal inhibitory concentration (IC50) values = 0.31 ± 0.02, 0.60 ± 0.03, 2.00 ± 0.13, 1.47 ± 0.08 and 1.48 ± 0.11 mmol/L, respectively), were observed. The contents of Leu-Tyr, Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr, Arg-Gly-Gly-Tyr, and Leu-Val-Ser were 155.04 ± 8.36, 2.08 ± 0.12, 1.95 ± 0.06, 22.70 ± 1.35, 0.25 ± 0.01, and 53.01 ± 2.73 μg/g, respectively, in the WOP. Pro-Tyr, Tyr-Gln, Ala-Pro-Ser-Tyr, Arg-Gly-Gly-Tyr, and Leu-Val-Ser are novel antioxidative/ACE inhibitory peptides that have not been previously reported. The results suggest that WOP could potentially be applied in the food industry as a functional additive.
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- 2021
22. Brain deep medullary veins on 3-T MRI in a population-based cohort
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Zhengyu Jin, Jiang-Tao Zhang, Fei Han, Li-Xin Zhou, Fei-Fei Zhai, Liying Cui, Dong-Hui Ao, Shuyang Zhang, Ming-Li Li, Jun Ni, Yi-Cheng Zhu, Ming Yao, and Ding-Ding Zhang
- Subjects
Adult ,Male ,China ,Pathology ,medicine.medical_specialty ,Medullary cavity ,Disease ,Vascular risk ,Cohort Studies ,03 medical and health sciences ,Population based cohort ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Aged ,030304 developmental biology ,0303 health sciences ,business.industry ,Incidence ,Neurodegeneration ,Brain ,Original Articles ,Middle Aged ,medicine.disease ,Cerebral Veins ,Magnetic Resonance Imaging ,Neurology ,Cerebral Small Vessel Diseases ,Susceptibility weighted imaging ,Female ,Neurology (clinical) ,Small vessel ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Our aim is to investigate whether vascular risk factors are associated with cerebral deep medullary veins (DMVs) and whether DMVs are associated with MRI markers of cerebral small vessel disease (CSVD) or risk of stroke. In a community-based cohort of 1056 participants (mean age 55.7 years), DMVs were identified on susceptibility-weighted imaging (SWI) and counted in periventricular regions. Neuroimaging markers including lacunes, whiter matter hyperintensity (WMH), microbleeds, enlarged perivascular space, and brain atrophy were evaluated. The number of DMVs decreased with age (p = 0.007). After adjusting for age and sex, the number of DMVs was not associated with traditional vascular risk factors. Fewer DMVs was associated with increase of WMH and lacunes, but the association vanished after adjustment for vascular risk factors. However, fewer DMVs were independently associated with brain atrophy (p
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- 2020
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23. Control measures for thermal effects during placement of span-scale girder segments on continuous steel box girder bridges
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Zhongxuan Yang, Rongqiao Xu, Jiang-tao Zhang, and Jin-feng Wang
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Bending (metalworking) ,business.industry ,0211 other engineering and technologies ,General Engineering ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Span (engineering) ,Residual ,Finite element method ,0201 civil engineering ,Structural load ,Reaction ,Buckling ,Girder ,021105 building & construction ,business ,Geology - Abstract
In this study, we examined the thermal effects throughout the process of the placement of span-scale girder segments on a 6×110-m continuous steel box girder in the Hong Kong-Zhuhai-Macao Bridge. Firstly, when a span-scale girder segment is temporarily stored in the open air, temperature gradients will significantly increase the maximum reaction force on temporary supports and cause local buckling at the bottom of the girder segment. Secondly, due to the temperature difference of the girder segments before and after girth-welding, some residual thermal deflections will appear on the girder segments because the boundary conditions of the structure are changed by the girth-welding. Thirdly, the thermal expansion and thermal bending of girder segments will cause movement and rotation of bearings, which must be considered in setting bearings. We propose control measures for these problems based on finite element method simulation with field-measured temperatures. The local buckling during open-air storage can be avoided by reasonably determining the appropriate positions of temporary supports using analysis of overall and local stresses. The residual thermal deflections can be overcome by performing girth-welding during a period when the vertical temperature difference of the girder is within 1 °C, such as after 22:00. Some formulas are proposed to determine the pre-set distances for bearings, in which the movement and rotation of the bearings due to dead loads and thermal loads are considered. Finally, the feasibility of these control measures in the placement of span-scale girder segments on a real continuous girder was verified: no local buckling was observed during open-air storage; the residual thermal deflections after girth-welding were controlled within 5 mm and the residual pre-set distances of bearings when the whole continuous girder reached its design state were controlled within 20 mm.
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- 2020
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24. A Multilevel Systemic Pan-cancer Analysis: Collagen Triple Helix Repeat Containing-1 is a Potential Target for Tumor Immunotherapy
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Hui-Chao Ruan, Rong qiang Yang, xiaobing Fu, Xianghua Wu, Jiang-Tao Zhang, and Changli Wang
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ComputingMethodologies_PATTERNRECOGNITION ,Pan cancer ,Chemistry ,medicine.medical_treatment ,Collagen helix ,Cancer research ,medicine ,Immunotherapy - Abstract
Background: Cancer is one of the leading causes of pathological death in humans. Although CTHRC1 is a prooncogene highly expressed in a variety of tumor tissues, the specific biological mechanisms of CTHRC1 involvement in cancer development need to be elucidated. Methods: In the present study, nine online bioinformatics databases were employed to explore the potential prognostic and grading value of CTHRC1 in generalized cancer as well as its potential role in regulating tumor immunity. Results: Data from GEPIA2.0, Oncomine, TNMplot, Kaplan-Meier Plotter and TISIDB database had consistently demonstrated that CTHRC1 was associated with the expression, prognosis and typing in most cancer tissues. Cbioportal and SMART analysis revealed that genomic changes and methylation of CTHRC1 in most tumor tissues. Finally, Sangerbox and TIMER database analysis suggested that CTHRC1 was involved in the changes of immune cell components in tumor immune microenvironment, with certain heterogeneity. Meanwhile, CTHRC1 was correlated with TMB, MSI, neoantigen and tumor immune checkpoint, especially CD276. Conclusion: CTHRC1 had the potential as a prognostic and grading molecular marker for pan-cancer. And CTHRC1-related targeting agents may be a novel breakthrough in tumor immunotherapy.
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- 2021
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25. Geometric state transfer method for construction control of a large-segment steel box girder with hoisting installation
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Jin-feng Wang, Hua-wei Xiang, Tian-mei Wu, Rongqiao Xu, and Jiang-tao Zhang
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State variable ,business.industry ,media_common.quotation_subject ,0211 other engineering and technologies ,General Engineering ,Elevation ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,State (functional analysis) ,Bridge (nautical) ,0201 civil engineering ,Position (vector) ,Girder ,021105 building & construction ,Eccentricity (behavior) ,business ,Joint (geology) ,media_common ,Mathematics - Abstract
This paper aims to address the problem of geometric state control of large-segment steel box girders in offshore hoisting during the construction of large-span bridges. First, the geometric state control indexes of a large-segment steel box girder are determined, such as the manufacturing parameters of the top and bottom slabs, the width of the annular joint, and the support position. Second, the geometric state equations and state transfer matrixes of large-segment steel box girders under different conditions are deduced by taking the mileage and elevation of control points as basic state variables. In application of the geometric state transfer method in the construction control of the Hong Kong-Zhuhai-Macao Bridge, the width of the annular joint and the position parameters for the support of the large-segment steel box girder are predicted precisely. Moreover, the manufacturing parameters of the top and bottom slabs of the steel box girders are calculated reliably. The measured values show that the width of the annular joint is basically the same with the difference of less than 2 mm, the eccentricity of bridge support is less than 20 mm, and the elevation error of the bridge deck is within −10 mm to +15 mm, which meets the construction accuracy. Using the geometric state transfer method, the rapid and accurate installation of the Hong Kong-Zhuhai-Macao Bridge has been realized, demonstrating that the precise control of the geometric state of a steel box girder with ectopic installation and multi-state transition can be realized by using the geometric state transfer method.
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- 2020
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26. Melatonin attenuates acute and chronic itch in mice: the antioxidant and anti-inflammatory effects of melatonin receptors
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Li, Zhang, Jiang-Tao, Zhang, Ya, Huang, Guo-Kun, Zhou, Yan, Zhou, Jiang-Ping, Yang, and Tong, Liu
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General Medicine - Abstract
Itch is a common symptom of skin diseases and significantly reduces patients' quality of life. Melatonin has anti-inflammatory and antioxidant effects. Our study examined the potential anti-itch effects of melatonin (N-acetyl-5-methoxytryptamine) in mice.We detected the effects of melatonin and its receptors on acute and chronic itch by conducting itching behavioral experiments in male C57 mice. Reactive oxygen species (ROS) levels and calcium ion (CaWe discovered that compound 48/80 (C48/80)- and chloroquine (CQ)-induced scratching were significantly decreased by intraperitoneal (i.p), intradermal, and intrathecal administration of melatonin in a dose-dependent manner in mice, and the co-administration of melatonin receptor antagonists abolished the anti-itch effects of i.d melatonin. The incubation of melatonin significantly decreased the intracellular ROS levels induced by C48/80 and CQ in cultured ND7/23 cells from a mouse x rat hybridoma nerve as neuron. Melatonin inhibited intracellular CaCollectively, our results indicate that melatonin attenuates acute and chronic itch, possibly via melatonin receptors, and its antioxidant, and anti-inflammatory effects in mice.
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- 2022
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27. Extracellular polymeric substances excreted by anammox sludge act as a barrier for As(III) invasion: Binding property and interaction mechanism
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Yu-Xi Yao, Wen-Jie Ma, Ye Wang, Xin-Xin Wu, Ren-Cun Jin, Ya-Fei Cheng, Bao-Cheng Huang, Jiang-Tao Zhang, and Li Guifeng
- Subjects
Environmental Engineering ,Health, Toxicology and Mutagenesis ,0208 environmental biotechnology ,chemistry.chemical_element ,02 engineering and technology ,010501 environmental sciences ,Wastewater ,01 natural sciences ,Hydrophobic effect ,Extracellular polymeric substance ,Bioreactors ,Environmental Chemistry ,Binding site ,Arsenic ,0105 earth and related environmental sciences ,Sewage ,Extracellular Polymeric Substance Matrix ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Pollution ,Acute toxicity ,020801 environmental engineering ,Biochemistry ,chemistry ,Anammox ,Toxicity ,Hydrophobic and Hydrophilic Interactions - Abstract
The arsenic in livestock wastewater would induce adverse impact on the biological treatment technology such as anaerobic ammonium oxidation (anammox) process. Extracellular polymeric substances (EPS) play an important role in resisting such toxicity. Unfortunately, the role of EPS in protecting anammox from As(III) and the mechanisms underlying the protection still remains unclear. This work comprehensively evaluated the acute toxicity of arsenic on anammox sludge and investigated the binding property and interaction mechanism. The results revealed that the half maximal inhibitory concentration (IC50) of As(III) on anammox sludge was estimated to be 408 mg L−1, which decreased to 41.97 mg L−1 when EPS was exfoliated. Complexation and hydrophobic interactions were the leading forces in preventing arsenic invasion. Protein was the main component that complexes with As(III), and O–H, –NH, –C O were binding sites. The response sequence of organic component in EPS to As(III) was ordered as hydrocarbons-proteins-polysaccharides-aliphatic amines.
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- 2021
28. The validity of the subspecies, Teinopalpus aureus wuyiensis Lee, from complete mitochondrial genome
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Wu, Zou, primary, Chao-Bin, Huang, additional, Lu, Wang, additional, Meng-na, Jiang, additional, Shan-yi, Zhou, additional, Jiang-tao, Zhang, additional, and Ju-ping, Zeng, additional
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- 2021
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29. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes
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Ya Huang, Li-Hua Chen, Di Liu, Ji Hu, Ruo-Xiao Cheng, Zhi-Hong Wang, Jiang-Tao Zhang, Tong Liu, Bing Wang, Cun-Jin Su, Ru-Rong Ji, and Yu Feng
- Subjects
0301 basic medicine ,Genetically modified mouse ,Hypoalgesia ,Diabetic neuropathy ,Methylglyoxal ,Medicine (miscellaneous) ,Pharmacology ,Streptozotocin ,medicine.disease ,03 medical and health sciences ,chemistry.chemical_compound ,Transient receptor potential channel ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Diabetes mellitus ,medicine ,Protein kinase A ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic neuropathy. Methods: Scratching behavior, mechanical itch (alloknesis), and thermal hypoalgesia were quantified after intradermal (i.d.) injection of MGO in naive mice or in diabetic mice induced by intraperitoneal (i.p.) injection of streptozotocin (STZ). Behavioral testing, patch-clamp recording, transgenic mice, and gene expression analysis were used to investigate the mechanisms underlying diabetic itch and hypoalgesia in mice. Results: I.d. injection of MGO evoked dose-dependent scratching in normal mice. Addition of MGO directly activated transient receptor potential ankyrin 1 (TRPA1) to induce inward currents and calcium influx in dorsal root ganglia (DRG) neurons or in TRPA1-expressing HEK293 cells. Mechanical itch, but not spontaneous itch was developed in STZ-induced diabetic mice. Genetic ablation of Trpa1 (Trpa1-/- ), pharmacological blockade of TRPA1 and Nav1.7, antioxidants, and mitogen-activated protein kinase kinase enzyme (MEK) inhibitor U0126 abrogated itch induced by MGO or in STZ-induced diabetic mice. Thermal hypoalgesia was induced by intrathecal (i.t.) injection of MGO or in STZ-induced diabetic mice, which was abolished by MGO scavengers, intrathecal injection of TRPA1 blockers, and in Trpa1-/- mice. Conclusion: This study revealed that Nav1.7 and MGO-mediated activation of TRPA1 play key roles in itch and hypoalgesia in a murine model of type 1 diabetes. Thereby, we provide a novel potential therapeutic strategy for the treatment of itch and hypoalgesia induced by diabetic neuropathy.
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- 2019
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30. Deciphering the response of anammox process to heavy metal and antibiotic stress: Arsenic enhances the permeability of extracellular polymeric substance and aggravates the inhibition of sulfamethoxazole
- Author
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Jiang-Tao Zhang, Zhi-Qi Ren, Nian-Si Fan, Jie-Yun Guo, Wen-Jie Ma, Lin-Qian Yu, Yu-Xi Yao, Xin-Xin Wu, and Ren-Cun Jin
- Subjects
medicine.drug_class ,General Chemical Engineering ,Antibiotics ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Industrial and Manufacturing Engineering ,Denitrifying bacteria ,Extracellular polymeric substance ,medicine ,Environmental Chemistry ,Arsenic ,biology ,Chemistry ,Sulfamethoxazole ,General Chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,0104 chemical sciences ,Wastewater ,Anammox ,Environmental chemistry ,0210 nano-technology ,Bacteria ,medicine.drug - Abstract
Anaerobic ammonium oxidation (anammox) process exhibits advantages in treating high-ammonium livestock wastewater, while the anammox bacteria is vulnerable to heavy metal and antibiotics. Arsenic and sulfonamides extensively existed in livestock wastewater; unfortunately, their effects on the anammox process have not yet been investigated. This work comprehensively evaluated the single and joint effects of As(III) and sulfamethoxazole (SMX) on the anammox process and revealed the related inhibitory mechanism. Anammox had extraordinary resistance to As(III) stress (0–50 mg L−1), while nitrogen removal sharply deteriorated under the stress from 50 mg L−1 As(III) and 3 mg L−1 SMX. Exogenous As(III) damaged the protection of extracellular polymeric substance (EPS) and aggravated the inhibition of SMX. As(III) had direct toxic effects on anammox bacteria, while enhanced denitrifying capacity was the reason for inhibition of anammox by SMX. Moreover, the host arsenic resistance genes were changed under SMX inhibition. The findings of this study enrich our knowledge of the anammox response to various pollutants, and provide the operational guidance for anammox process to treat wastewater containing antibiotic and heavy metal.
- Published
- 2021
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31. Association among Parkinsonism-related motor complaints, cerebral small vessel disease, and cerebrovascular risk factors in a community-dwelling population
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Yang Guo, Cai-hong Ji, Fei Han, Jiang-tao Zhang, Fei-fei Zhai, Li-xin Zhou, Jun Ni, Ming Yao, Zheng-yu Jin, Shu-yang Zhang, Li-ying Cui, and Yicheng Zhu
- Abstract
Background Parkinsonism-related motor complaints are commonly seen in the elderly. Our study aimed to investigate the association among Parkinsonism-related motor complaints, cerebral small vessel disease and cerebrovascular risk factors in a community-dwelling population in a Chinese rural area.Methods Individuals who were 50 years old or older, were independently living, were well-functioning, and had no history of ischemic or hemorrhagic stroke, were included. Brain magnetic resonance imaging (MRI), quantified motor function assessment, and questionnaire screening for Parkinsonism-related motor complaints were performed. Clinical data including cerebrovascular risk factors were collected. In univariate analysis, Chi-square test and student t-test were used to compare dichotomous variables and continuous variables, respectively, between individuals with or without motor complaints. In multivariate analysis, binary Logistic regression models were generated to determine risk factors for Parkinsonism-related motor complaints. General linear models were used to compare motor parameters between individuals with or without motor complaints. Results In the final analysis, 854 people were included. Individuals with motor complaints had a longer time for finger taping (6.2s v.s. 5.6s, p = 0.006), and a longer time for 3m-walking(4.0s v.s. 3.6s, p = 0.034) than did those without motor complaints. Hypertension was associated with motor complaints (odds ratio, 1.82; 95% confidence interval [CI], [1.21, 2.73]; p = 0.004). Age was not associated with motor complaints; none of the neuroimaging markers of cerebral small vessel disease was associated with motor complaints. Conclusion Hypertension is associated with Parkinsonism-related motor complaints. Better management of hypertension may prevent mobility limitation in the elderly. The questionnaire that we used for Parkinsonism is not suitable for screening small vessel disease in a community-dwelling population.
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- 2019
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32. Residual stresses created during curing of a polymer matrix composite using a viscoelastic model
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David J. Smith, Martyn J Pavier, Mei Zhang, Jiang Tao Zhang, and Shuxin Li
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Polymer-matrix composites (PMCs) ,Materials science ,Viscoelastic constitutive model ,Composite number ,Constitutive equation ,Residual stress ,General Engineering ,Finite element analysis(FEA) ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Viscoelasticity ,Deborah number ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Ceramics and Composites ,Stress relaxation ,Curing ,Composite material ,0210 nano-technology ,Curing (chemistry) ,Shrinkage - Abstract
A modified viscoelastic constitutive model is proposed to predict cure-induced residual stresses in polymer matrix composites. The modifications rely on using the inverse of the Deborah number to describe regimes corresponding to a fully relaxed state, a viscoelastic state and an elastic state. The composite is only in a viscoelastic state for limited ranges of the Deborah number. By considering the evolution of the Deborah number during curing of the AS4/3501-6 composite, the composite is in a fully relaxed state when it is cured at high temperature and the degree of cure is lower than 0.73, and no further changes in the viscoelastic characteristics when the degree of cure is higher than 0.8. A 3D simulation of a composite laminate plate is used to predict the evolution of the residual stresses. The analysis reveals that the accurate simulation on the cure-induced residual stress should include the last two states of the entire cure process, and consider the stress relaxation, thermal deformation and chemical shrinkage.
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- 2016
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33. Enhanced electrochemical performance of BaZr0.1Ce0.7Y0.1Yb0.1O3−δ electrodes for hydrogen and methane oxidation in solid oxide fuel cells by Pd or Cu0.5Pd0.5 impregnation
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Li Jian, Jian Pu, Bo Chi, Fengli Liang, and Jiang-Tao Zhang
- Subjects
Materials science ,Hydrogen ,Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,Oxide ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Electrochemistry ,Anode ,chemistry.chemical_compound ,chemistry ,Electrode ,Solid oxide fuel cell ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Polarization (electrochemistry) ,Yttria-stabilized zirconia - Abstract
The anode material BaZr 0.1 Ce 0.7 Y 0.1 Yb 0.1 O 3− δ (BZCYYb) for solid oxide fuel cells (SOFCs) is prepared by solid state reaction method and its chemical compatibility with Y 2 O 3 stabilized ZrO 2 (YSZ) is evaluated. The electrochemical performance of the pure and Pd- and Cu 0.5 Pd 0.5 -impreganated BZCYYb electrodes is characterized in the temperature range between 650 and 750 °C by AC impedance spectroscopy in H 2 and/or CH 4 atmospheres, respectively, under the condition of open circuit. It is confirmed that the BZCYYb is chemically compatible with the YSZ at temperatures below 1000 °C. The polarization resistance of the BZCYYb anode in H 2 is decreased from 2.08 to 0.51 Ω cm 2 as the measuring temperature increases from 650 to 750 °C with an activation energy of 117 kJ mol −1 . With Pd- or Cu 0.5 Pd 0.5 -impregnation, the polarization resistance of the BZCYYb electrode in H 2 is reduced significantly to approximately 0.40 Ω cm 2 at 650 °C and 0.12 Ω cm 2 at 750 °C. With dry CH 4 as the fuel, the polarization resistance of the Pd- and Cu 0.5 Pd 0.5 -impregnated BZCYYb anodes is obviously increased below 1.00 Ω cm 2 at 650 °C and 0.22 Ω cm 2 at 750 °C. Both Pd and Cu 0.5 Pd 0.5 impregnations are equivalently effective in enhancing the electrochemical performance of the BZCYYb anode.
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- 2012
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34. A cadaveric study of posterior dislocation after total hip replacement - Effects of head diameter and acetabular anteversion
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F Y Ng, Kwong Yuen Chiu, Jiang Tao Zhang, and Chun Hoi Yan
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Joint Instability ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Arthroplasty, Replacement, Hip - adverse effects - instrumentation - methods ,Femur Head - anatomy and histology ,Acetabulum - anatomy and histology ,Arthroplasty, Replacement, Hip ,Total hip replacement ,Joint Dislocations ,Dislocations ,Prosthesis Design ,Femoral head ,Postoperative Complications ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Computer navigation ,Range of Motion, Articular ,Hip Joint - anatomy and histology - physiology ,Orthodontics ,Original Paper ,business.industry ,Acetabulum ,Femur Head ,Anatomy ,medicine.anatomical_structure ,Orthopedic surgery ,Head (vessel) ,Surgery ,Posterior dislocation ,Hip Joint ,Hip Prosthesis ,business ,Cadaveric spasm - Abstract
The size of the femoral head and acetabular anteversion are crucial for stability in total hip replacements. This study examined the effects of head diameter and acetabular anteversion on the posterior instability after total hip replacement in an in vivo setting. The acetabular shell was inserted at 0-20° of anteversion at five degree intervals. By using different head sizes (28 mm, 32 mm, 36 mm), the degrees of dislocation were recorded by computer navigation. The 36-mm group consistently showed better stability compared with the 32- and 28-mm groups, regardless of the degree of cup anteversion. Within each group of head size, the hip was significantly more stable when the cup anteversion increased from 0° to 10°. The difference became insignificant when it increased from 15° to 20°. © Springer-Verlag 2010., link_to_OA_fulltext
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- 2011
35. [National external quality assessment and comparability of assays for tumor markers measurements]
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Jiang-tao, Zhang, Chuan-bao, Zhang, Rong, Ma, Hai-jian, Zhao, Jing, Wang, Zhi-guo, Wang, and Wen-xiang, Chen
- Subjects
Automation ,CA-19-9 Antigen ,Quality Assurance, Health Care ,Clinical Laboratory Techniques ,Biomarkers, Tumor ,Radioimmunoassay ,Humans ,Enzyme-Linked Immunosorbent Assay ,alpha-Fetoproteins ,Prostate-Specific Antigen ,Carcinoembryonic Antigen - Abstract
To evaluate the performance of tumor markers (TM) measurements in clinical laboratories by external quality assessment (EQA) and investigate the comparability of assays for TM.Ten quality control sera specimens were distributed to 586 laboratories by global Express Mail Services (EMS) in March 2008 and tested twice with 5 specimens each time. Analytes were total prostate specific antigen (PSA), free PSA, carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), human chorionic gonadotrophin (HCG), beta-HCG, carbohydrate antigen 19-9 (CA19-9), cancer antigen 15-3 (CA 15-3), cancer antigen 125 (CA125), beta-2-microglobulin and ferritin. The collected data were divided into peer groups according to analyzers or methods and the median of peer group was adopted as the target value (TV) separately after outlier removal. Two standard deviations of the median were set as the limit of difference.The first TM EQA results of 2008 showed that the pass percentage of all participating laboratories ranged from 87.3% (CA125) to 95.5% (beta-2-microglobulin). And the second batch ranged from 83.5% (HCG) to 94.0% (beta-2-microglobulin). The coefficient variances (CVs) of intra-group values determined by automatic analyzers were lesser than 15% for each test of every specimen. The CVs of radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) were over 20% and 50% respectively. The inter-group medians of 9 tests showed CVs20% with HCG 13.4% and ferritin 15.7%. The CV of paired medians of some automatic analyzers was small and showed no statistical significance (all Z1.890, all P0.05).The analytical performance of automatic analyzers is superior to RIA and ELISA. There is an excellent comparability within automatic analyzers for TM measurements and a lack of comparability within RIA and ELISA. Noncomparability is found in over 80% of TM assays.
- Published
- 2010
36. A cadaveric study of posterior dislocation after total hip replacement-effects of head diameter and acetabular anteversion.
- Author
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Fu Yuen Ng, Jiang Tao Zhang, Kwong Yuen Chiu, and Chun Hoi Yan
- Subjects
- *
TOTAL hip replacement , *HIP surgery , *ARTHROPLASTY , *ARTIFICIAL hip joints , *ARTIFICIAL joints - Abstract
The size of the femoral head and acetabular anteversion are crucial for stability in total hip replacements. This study examined the effects of head diameter and acetabular anteversion on the posterior instability after total hip replacement in an in vivo setting. The acetabular shell was inserted at 0-20° of anteversion at five degree intervals. By using different head sizes (28 mm, 32 mm, 36 mm), the degrees of dislocation were recorded by computer navigation. The 36-mm group consistently showed better stability compared with the 32- and 28-mm groups, regardless of the degree of cup anteversion. Within each group of head size, the hip was significantly more stable when the cup anteversion increased from 0° to 10°. The difference became insignificant when it increased from 15° to 20°. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
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