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13. Sleep-Disordered Breathing and Peripheral Arterial Disease: Current Evidence.

Author

Xia, Yunyan, You, Kai, Xiong, Yuanping, and Jiang, Hongqun

Subjects
ATHEROSCLEROSIS, MEDICAL information storage & retrieval systems, MEDLINE, ONLINE information services, PERIPHERAL vascular diseases, RISK assessment, SLEEP apnea syndromes, SYSTEMATIC reviews, DISEASE complications, DISEASE risk factors
Abstract

Introduction: Sleep-disordered breathing (SDB) is associated with atherosclerosis. Peripheral arterial disease (PAD) is a manifestation of atherosclerosis in lower extremity arteries. No systematic review addressing the relationship between PAD and SDB was found. We performed this study aimed to summarize the relationship between SDB and PAD described in current clinical studies. Material and Methods: PubMed and Embase electronic databases were searched for clinical articles (published before 3 April, 2019) describing studies that evaluated the association between SDB and PAD. We showed the results involved in the association in clinical studies. Results: In total, 8 clinical studies have been included, and most of them were cross-sectional studies. Six articles demonstrated the coexistence of SDB and PAD, evidenced by high prevalence of SDB in patients with PAD and vice versa. Meanwhile, the included studies exhibited independent positive associations between SDB or sleep parameters and PAD after adjusting for multiple confounders. Conclusion: From present clinical prospective, positive association between SDB and PAD was shown. More prospective, randomized controlled studies are needed to establish the cause–effect relationships involved. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Differentiation of induced pluripotent stem cells for future olfactory repair using an indirect co-culture technique

Author

Xiong, Shan, Zhang, Silin, Guan, Lina, Chen, Jing, Tu, Xiang, Li, Qiang, and Jiang, Hongqun

Subjects
nervous system, Original Article
Abstract

This study was to investigate the differentiation potential of iPSCs into olfactory receptor neurons and mitral/tufted cells in vitro. We extracted mouse embryonic fibroblast and prepared feeding layer, where mouse iPSCs were inoculated on; RT-PCR were used to identify iPSCs pluripotency genes Oct4, Nanog and Sox2. Then, we separated the olfactory epithelium and olfactory bulb from mice, which contained respectively olfactory receptor neurons and mitral/tufted cells, co-cultured iPSCs with olfactory epithelium cell and olfactory bulb, and identified differentiated cells with the olfactory receptor neurons markers (OMP, GAP43, NCAM), mitral/tufted cells markers (TBX21, Iba1) after 14 days co-culturing by immunofluorescence and RT-PCR. We successfully established a stable culture system of mouse iPSCs and RT-PCR showed that pluripotency genes (Oct4, Nanog, Sox2) were expressed in mouse iPSCs. Immunocytochemical analysis or RT-PCR results indicated that the differentiated iPSCs can express olfactory receptor neurons markers (OMP, GAP43, NCAM) and mitral/tufted cells markers (TBX21, Iba1) after being co-culture with olfactory epithelium or olfactory bulb. We conclude that Mouse iPSCs can be differentiated into olfactory receptor neuron-like cells and mitral/tufted-like cells in vitro.

Published
2017

15. Analysis of 3 Surgical Approaches for the Treatment of Cerebrospinal Fluid Otorrhea: A Case Series Report

Author

Sun, Shasha, Yu, Hongbing, Li, Yanling, Wang, Kai, Jiang, Hongqun, Zhang, Zhiyuan, Luo, Wugen, and Yu, Rong

Abstract

Background:This case series report aimed to present three surgical approaches used for the treatment of cerebrospinal fluid (CSF) otorrhea, providing less invasive surgical options for managing this condition. Methods:Clinical data of 26 patients with CSF otorrhea, who underwent treatment using three surgical methods between June 2012 and June 2022, were retrospectively analyzed. The study collected information on patients’ basic demographic characteristics, chief complaints, location of the defect, results of otorrhea endoscopic examination, findings from skull base thin-slice computed tomography (CT) examination, and causes of CSF otorrhea. Postoperative outcomes of CSF otorrhea were followed up. Results:Among the 26 cases of CSF otorrhea, there were 13 (50%) males and 13 (50%) females who underwent treatment using the three surgical methods. The etiology of CSF otorrhea included 10 (38%) cases of spontaneous CSF otorrhea, including 2 (8%) cases of congenital inner ear deformity and 8 (31%) cases without obvious inducement. Additionally, there were 5 (19%) cases of trauma, 6 (23%) cases of cholesteatoma complications, 3 (12%) cases of postoperative complications of brain tumor, 1 (4%) case of radiotherapy, and 1 (4%) case of a malignant tumor. A total of 12 (46%) cases of CSF otorrhea were treated by local repair of the defect. Furthermore, 3 (12%) cases underwent local repair of the defect combined with sealing of the tympanic sinus entrance, while 11 (42%) cases underwent local repair of the defect combined with sealing of the eustachian tube and the external auditory canal. No recurrence of CSF otorrhea was observed during the 6-month to 10-year follow-up period after surgery. Conclusion:The three methods for CSF otorrhea, including local defect repair, local defect repair combined with sealing of the tympanic sinus entrance, and sealing of the eustachian tube and the external auditory canal, demonstrated successful outcomes in appropriately selected patients.

Published
2024
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17. Sleep-Disordered Breathing and Peripheral Arterial Disease: Current Evidence.

Author

Xia Y, You K, Xiong Y, and Jiang H

Subjects
Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Peripheral Arterial Disease epidemiology, Prevalence, Prospective Studies, Sleep Apnea Syndromes epidemiology, Peripheral Arterial Disease complications, Sleep Apnea Syndromes complications
Abstract

Introduction: Sleep-disordered breathing (SDB) is associated with atherosclerosis. Peripheral arterial disease (PAD) is a manifestation of atherosclerosis in lower extremity arteries. No systematic review addressing the relationship between PAD and SDB was found. We performed this study aimed to summarize the relationship between SDB and PAD described in current clinical studies., Material and Methods: PubMed and Embase electronic databases were searched for clinical articles (published before 3 April, 2019) describing studies that evaluated the association between SDB and PAD. We showed the results involved in the association in clinical studies., Results: In total, 8 clinical studies have been included, and most of them were cross-sectional studies. Six articles demonstrated the coexistence of SDB and PAD, evidenced by high prevalence of SDB in patients with PAD and vice versa. Meanwhile, the included studies exhibited independent positive associations between SDB or sleep parameters and PAD after adjusting for multiple confounders., Conclusion: From present clinical prospective, positive association between SDB and PAD was shown. More prospective, randomized controlled studies are needed to establish the cause-effect relationships involved.

Published
2021
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