570 results on '"Jensen, Lisette Okkels"'
Search Results
2. Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development
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Frederiksen, Peter Hartmund, primary, Linde, Louise, additional, Gregers, Emilie, additional, Udesen, Nanna Louise Junker, additional, Helgestad, Ole K, additional, Banke, Ann, additional, Dahl, Jordi Sanchez, additional, Povlsen, Amalie L, additional, Jensen, Lisette Okkels, additional, Larsen, Jeppe P, additional, Lassen, Jens, additional, Schmidt, Henrik, additional, Ravn, Hanne Berg, additional, and Moller, Jacob Eifer, additional
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- 2024
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3. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic
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De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, LOH, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang-yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica
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- 2021
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4. Very late Magmaris scaffold restenosis: a 6-year serial optical coherence tomography case report.
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Trøan, Jens, Hansen, Kirstine Nørregaard, Noori, Manijeh, Lassen, Jens Flensted, and Jensen, Lisette Okkels
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NON-ST elevated myocardial infarction ,OPTICAL coherence tomography ,ATHEROSCLEROTIC plaque ,HEART diseases ,HEALING - Abstract
Background Bioresorbable scaffolds (BRS) have been proposed as an alternative to drug-eluting stents (DES), offering radial support during the early phases of healing, while potentially reducing the risk of long-term complications. A magnesium-based BRS (MgBRS) has shown promising results after implantation. However, there is a lack of knowledge regarding the long-term outcomes. Case summary A 62-year-old man with hypertension, dyslipidaemia, family history of ischaemic heart disease, and previous myocardial infarction, presented with non-ST-elevation myocardial infarction (NSTEMI). Six years prior, he also had a NSTEMI and a mid-left anterior descending artery (LAD) lesion was treated with a 3.0/25 mm MgBRS. Post-implantation optical coherence tomography (OCT) revealed proximal edge dissection, and a second MgBRS 3.0/15 mm was implanted. Optical coherence tomography of the scaffold-treated segment was performed after 6 and 12 months with no sign of restenosis. The current angiogram showed a restenosis in the previously MgBRS-treated segment in LAD. Optical coherence tomography showed a plaque rupture in a thin cap fibro-atheroma and scaffold remnants. The lesion was pre-dilated and stented with a 3.0/20 mm DES and post-dilated with a 3.5 mm non-compliant balloon. Discussion Most cases of late scaffold failure showed acquired mal-apposition, which also can be related to the degrading process, or uncovered struts, none of which were seen in our case at 6 or 12 months. This case represents an insight into the vascular healing and potential mechanisms for failure of the MgBRS, with serial OCT recording at implantation, and after 6 months, 12 months, and 6 years. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016
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Jensen, Esben Skov, Olesen, Kevin Kris Warnakula, Gyldenkerne, Christine, Thrane, Pernille Gro, Jensen, Lisette Okkels, Raungaard, Bent, Poulsen, Per Løgstrup, Thomsen, Reimar Wernich, and Maeng, Michael
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- 2021
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6. Ten-year cardiovascular risk in diabetes patients without obstructive coronary artery disease: a retrospective Western Denmark cohort study
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Olesen, Kevin Kris Warnakula, Madsen, Morten, Gyldenkerne, Christine, Thrane, Pernille Gro, Thim, Troels, Jensen, Lisette Okkels, Bøtker, Hans Erik, Sørensen, Henrik Toft, and Maeng, Michael
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- 2021
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7. Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study
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Mørk, Sivagowry Rasalingam, Stengaard, Carsten, Linde, Louise, Møller, Jacob Eifer, Jensen, Lisette Okkels, Schmidt, Henrik, Riber, Lars Peter, Andreasen, Jo Bønding, Thomassen, Sisse Anette, Laugesen, Helle, Freeman, Phillip Michael, Christensen, Steffen, Greisen, Jacob Raben, Tang, Mariann, Møller-Sørensen, Peter Hasse, Holmvang, Lene, Gregers, Emilie, Kjaergaard, Jesper, Hassager, Christian, Eiskjær, Hans, and Terkelsen, Christian Juhl
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- 2021
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8. Outcome in Elderly Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction
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Ratcovich, Hanna Louise, Josiassen, Jakob, Helgestad, Ole Kristian Lerche, Linde, Louise, Jensen, Lisette Okkels, Ravn, Hanne Berg, Joshi, Francis R., Engstrøm, Thomas, Schmidt, Henrik, Hassager, Christian, Møller, Jacob E., and Holmvang, Lene
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- 2022
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9. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention: A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial)
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Maeng, Michael, Bøtker, Hans Erik, Christiansen, Evald Høj, Raungaard, Bent, Jensen, Svend Eggert, Hansen, Henrik Steen, Jensen, Lisette Okkels, Bargsteen, Helle, Pedersen, Helle, Jørgensen, Lars P., Ottosen, Pia, Pedersen, Karin M., Thygesen, Kristian, Sørensen, Jacob Thorsted, Andersen, Henning Rud, Kahlert, Johnny, Terkelsen, Christian Juhl, Kristensen, Steen Dalby, Carstensen, Steen, Aarøe, Jens, Villadsen, Anton Boel, Lassen, Jens Flensted, Thim, Troels, Eftekhari, Ashkan, Veien, Karsten Tange, Hansen, Knud Nørregaard, and Junker, Anders
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- 2019
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10. Fractional Flow Reserve Versus Angiographically-Guided Coronary Artery Bypass Grafting
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Thuesen, Anne Langhoff, Riber, Lars Peter, Veien, Karsten Tange, Christiansen, Evald Høj, Jensen, Svend Eggert, Modrau, Ivy, Andreasen, Jan Jesper, Junker, Anders, Mortensen, Poul Erik, and Jensen, Lisette Okkels
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- 2018
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11. TCT-418 Impact of Diabetes on Clinical Outcomes After Percutaneous Coronary Intervention: 5-Year Results of the SORTOUT IX Trial Comparing the Polymer-Free Biolimus A9-Coated Stent to the Ultra-Thin Strut Biodegradable Polymer Sirolimus-Eluting Stent
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Hansen, Kirstine, primary, Christiansen, Evald, additional, Ellert, Julia, additional, Eftekhari, Ashkan, additional, Jakobsen, Lars, additional, Veien, Karsten, additional, Freeman, Phillip, additional, Jensen, Rebekka Vibjerg, additional, Noori, Manijeh, additional, Støttrup, Nicolaj, additional, Junker, Anders, additional, Trøan, Jens, additional, Maeng, Michael, additional, Terkelsen, Christian, additional, Raungaard, Bent, additional, Lassen, Jens, additional, and Jensen, Lisette Okkels, additional
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- 2023
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12. TCT-669 Impact of Acute Coronary Syndromes on Long-Term Clinical Outcomes After Percutaneous Coronary Intervention With the Biolimus-Coated BioFreedom Stent or Biodegradable Polymer Sirolimus-Eluting Orsiro Stent: From the SORT OUT IX Trial
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Noori, Manijeh, primary, Christiansen, Evald, additional, Veien, Karsten, additional, Eftekhari, Askhan, additional, Jakobsen, Lars, additional, Ellert, Julia, additional, Jensen, Rebekka Vibjerg, additional, Hansen, Kirstine, additional, Støttrup, Nicolaj, additional, Freeman, Phillip, additional, Junker, Anders, additional, Terkelsen, Christian, additional, Jensen, Svend Eggert, additional, Maeng, Michael, additional, Lassen, Jens, additional, and Jensen, Lisette Okkels, additional
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- 2023
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13. TCT-158 The Impact of Sex and Age on Long-Term Outcome After Percutaneous Coronary Interventions: A Pooled Analysis of the Randomized Controlled SORT OUT Trials
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Holck, Emil, primary, Jakobsen, Lars, additional, Eftekhari, Ashkan, additional, Freeman, Phillip, additional, Kahlert, Johnny, additional, Lassen, Jens, additional, Jensen, Lisette Okkels, additional, and Christiansen, Evald, additional
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- 2023
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14. Neutrophil Gelatinase-Associated Lipocalin (NGAL) Measured at Admission is Associated With Development of Late Cardiogenic Shock and Mortality in Patients With ST-Segment Elevation Myocardial Infarction
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Frydland, Martin, Møgelvang, Rasmus, Møller, Jacob Eifer, Helgestad, Ole K. L., Holmvang, Lene, Mark, Peter D., Jensen, Lisette Okkels, and Hassager, Christian
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- 2021
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15. Instantaneous wave free ratio vs. fractional flow reserve and 5-year mortality: iFR SWEDEHEART and DEFINE FLAIR
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Eftekhari, Ashkan, primary, Holck, Emil Nielsen, additional, Westra, Jelmer, additional, Olsen, Niels Thue, additional, Bruun, Niels Henrik, additional, Jensen, Lisette Okkels, additional, Engstrøm, Thomas, additional, and Christiansen, Evald Høj, additional
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- 2023
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16. Sex Differences in 10-Year Outcomes After Percutaneous Coronary Intervention With Drug-Eluting Stents: Insights From the DECADE Cooperation
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Coughlan, J J, Räber, Lorenz, Brugaletta, Salvatore, Kufner, Sebastian, Maeng, Michael, Jensen, Lisette Okkels, Ortega-Paz, Luis, Bär, Sarah, Laugwitz, Karl-Ludwig, Madsen, Morten, Heg, Dik, Aytekin, Alp, Windecker, Stephan, Olesen, Kevin Kris Warnakula, Sabaté, Manel, Kastrati, Adnan, and Cassese, Salvatore
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Male ,Sex Characteristics ,Myocardial Infarction/complications ,Drug-Eluting Stents/adverse effects ,Kaplan-Meier Estimate ,Prosthesis Design ,Treatment Outcome ,Risk Factors ,Physiology (medical) ,Humans ,Female ,Stents/adverse effects ,610 Medizin und Gesundheit ,Cardiology and Cardiovascular Medicine ,Thrombosis/etiology ,Percutaneous Coronary Intervention/adverse effects - Abstract
Background: Although some studies have investigated sex-related outcomes up to 5 years after percutaneous coronary intervention (PCI), analyses at longer follow-up (ie, to 10 years) in large cohorts treated exclusively with drug-eluting stent (DES) platforms are lacking. Therefore, this study aimed to define whether sex-related differences in long-term outcomes after PCI persist both in the DES era and at longer-term follow-up. Methods: Individual data of patients treated with DES in 5 randomized controlled trials with 10-year follow-up were pooled. Patients were divided into 2 groups by sex. The analysis of individual participant data was performed using a 1-stage approach by entering a clustering effect by parent study in all univariable and multivariable models focusing on sex. The main outcomes of interest for this analysis included cardiovascular death, myocardial infarction, repeat revascularization, and definite stent thrombosis to 10 years after PCI. Survival was analyzed by the Kaplan-Meier method to estimate the time to first event, and differences between the 2 groups were tested with the log-rank test. Hazard ratios (HRs) and 95% CIs were calculated with a Cox proportional hazards model. Conventional multivariable analyses with adjustment for relevant variables were performed. Results: Among 9700 patients undergoing PCI with DES implantation included in the present analysis, 2296 were women and 7404 were men. Through to 10 years, cardiovascular death occurred in 407 of the 2296 female patients and 1012 of the 7404 male patients (adjusted HR [HR adj ], 0.94 [95% CI, 0.80–1.11]). Female sex was associated with a lower risk of repeat revascularization of the target lesion (HR adj , 0.80 [95% CI, 0.74–0.87]), target vessel (HR adj , 0.81 [95% CI, 0.76–0.87]), and nontarget vessels (HR adj , 0.69 [95% CI, 0.62–0.77]). Compared with male patients, female patients displayed an increased risk of myocardial infarction in the first 30 days after PCI with DES (HR adj , 1.65 [95% CI, 1.24–2.19]) but a comparable risk of myocardial infarction thereafter. The risk of definite stent thrombosis was not significantly different between female and male patients (HR adj , 1.14 [95% CI, 0.89–1.47]). Conclusions: Through to 10-year follow-up after PCI with DES, female patients are at increased risk of early myocardial infarction, receive fewer repeat revascularizations, and have no difference in cardiovascular mortality compared with male patients.
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- 2023
17. The Western Denmark Heart Registry: Its Influence on Cardiovascular Patient Care
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Schmidt, Morten, Maeng, Michael, Madsen, Morten, Sørensen, Henrik Toft, Jensen, Lisette Okkels, and Jakobsen, Carl-Johan
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- 2018
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18. Impact of COVID-19 pandemic and diabetes on mechanical reperfusion in patients with STEMI: insights from the ISACS STEMI COVID 19 Registry
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De Luca, Giuseppe, Cercek, Miha, Jensen, Lisette Okkels, Vavlukis, Marija, Calmac, Lucian, Johnson, Tom, Roura i Ferrer, Gerard, Ganyukov, Vladimir, Wojakowski, Wojtek, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Laine, Mika, Dirksen, Maurits, Casella, Gianni, Kala, Petr, Díez Gil, José Luis, Becerra, Victor, De Simone, Ciro, Carrill, Xavier, Scoccia, Alessandra, Lux, Arpad, Kovarnik, Tomas, Davlouros, Periklis, Gabrielli, Gabriele, Flores Rios, Xacobe, Bakraceski, Nikola, Levesque, Sébastien, Guiducci, Vincenzo, Kidawa, Michał, Marinucci, Lucia, Zilio, Filippo, Galasso, Gennaro, Fabris, Enrico, Menichelli, Maurizio, Manzo, Stephane, Caiazzo, Gianluca, Moreu, Jose, Sanchis Forés, Juan, Donazzan, Luca, Vignali, Luigi, Teles, Rui, Bosa Ojeda, Francisco, Lehtola, Heidi, Camacho-Freiere, Santiago, Kraaijeveld, Adriaan, Antti, Ylitalo, Boccalatte, Marco, Martínez-Luengas, Iñigo Lozano, Scheller, Bruno, Alexopoulos, Dimitrios, Uccello, Giuseppe, Faurie, Benjamin, Gutierrez Barrios, Alejandro, Wilbert, Bor, Cortese, Giuliana, Moreno, Raul, Parodi, Guido, Kedhi, Elvin, and Verdoia, Monica
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- 2020
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19. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with ST-Elevation Myocardial Infarction and Its Association with Acute Kidney Injury and Mortality
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Højagergaard, Mathias Alexander, primary, Beske, Rasmus Paulin, additional, Hassager, Christian, additional, Holmvang, Lene, additional, Jensen, Lisette Okkels, additional, Shacham, Yacov, additional, Meyer, Martin Abild Stengaard, additional, Moeller, Jacob Eifer, additional, Helgestad, Ole Kristian Lerche, additional, Mark, Peter Dall, additional, Møgelvang, Rasmus, additional, and Frydland, Martin, additional
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- 2023
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20. The SABRE Trial (Sirolimus Angioplasty Balloon for Coronary In-Stent Restenosis): Angiographic Results and 1-Year Clinical Outcomes
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Verheye, Stefan, Vrolix, Mathias, Kumsars, Indulis, Erglis, Andrejs, Sondore, Dace, Agostoni, Pierfrancesco, Cornelis, Kristoff, Janssens, Luc, Maeng, Michael, Slagboom, Ton, Amoroso, Giovanni, Jensen, Lisette Okkels, Granada, Juan F., and Stella, Pieter
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- 2017
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21. Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation: An Angiographic and Optical Coherence Tomography TROFI II Substudy
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Yamaji, Kyohei, Brugaletta, Salvatore, Sabaté, Manel, Iñiguez, Andrés, Jensen, Lisette Okkels, Cequier, Angel, Hofma, Sjoerd H., Christiansen, Evald Høj, Suttorp, Maarten, van Es, Gerrit Anne, Sotomi, Yohei, Onuma, Yoshinobu, Serruys, Patrick W., Windecker, Stephan, and Räber, Lorenz
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- 2017
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22. Comparison of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: 3-Year Clinical Outcomes in the Randomized SORT OUT VI Trial
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Raungaard, Bent, Thygesen, Kristian, Sørensen, Jacob Thorsted, Nørgaard, Bjarne Linde, Andersen, Søren Lindholt, Madsen, Morten, Jensen, Svend Eggert, Christiansen, Evald Høj, Bøtker, Hans Erik, Hansen, Henrik Steen, Jensen, Lisette Okkels, Christiansen, Evald H., Hansen, Henrik S., Ravkilde, Jan, Thuesen, Leif, Aarøe, Jens, Villadsen, Anton B., Terkelsen, Christian J., Krusell, Lars R., Maeng, Michael, Kristensen, Steen D., Veien, Karsten T., Hansen, Knud N., Junker, Anders, Andersen, Søren L., Jensen, Svend E., and Jensen, Lisette O.
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- 2017
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23. Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle
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Josiassen, Jakob, Helgestad, Ole Kristian Lerche, Udesen, Nanne Louise Junker, Banke, Ann, Frederiksen, Peter Hartmund, Hyldebrandt, Janus Adler, Schmidt, Henrik, Jensen, Lisette Okkels, Hassager, Christian, Ravn, Hanne Berg, and Møller, Jacob E.
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- 2020
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24. Randomized Comparison of the Polymer-Free Biolimus-Coated BioFreedom Stent With the Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Orsiro Stent in an All-Comers Population Treated With Percutaneous Coronary Intervention: The SORT OUT IX Trial
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Jensen, Lisette Okkels, Maeng, Michael, Raungaard, Bent, Kahlert, Johnny, Ellert, Julia, Jakobsen, Lars, Villadsen, Anton Boel, Veien, Karsten Tange, Kristensen, Steen Dalby, Ahlehoff, Ole, Carstensen, Steen, Christensen, Martin Kirk, Terkelsen, Christian Juhl, Engstroem, Thomas, Hansen, Knud Nørregaard, Bøtker, Hans Erik, Aaroe, Jens, Thim, Troels, Thuesen, Leif, Freeman, Philip, Aziz, Ahmed, Eftekhari, Ashkan, Junker, Anders, Jensen, Svend Eggert, Lassen, Jens Flensted, Hansen, Henrik Steen, and Christiansen, Evald Høj
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- 2020
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25. Admission Leukocyte Count is Associated with Late Cardiogenic Shock Development and All-Cause 30-Day Mortality in Patients with St-Elevation Myocardial Infarction
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Klein, Anika, Wiberg, Sebastian, Hassager, Christian, Winther-Jensen, Matilde, Frikke-Schmidt, Ruth, Bang, Lia Evi, Lindholm, Matias Greve, Holmvang, Lene, Moeller-Helgestad, Ole, Ravn, Hanne Berg, Jensen, Lisette Okkels, Kjaergaard, Jesper, Moeller, Jacob Eifer, and Frydland, Martin
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- 2019
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26. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
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De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Jensen, Lisette Okkels, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra Munoz, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silberman, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehitola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional
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- 2023
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27. Instantaneous wave free ratio vs. fractional flow reserve and 5-year mortality: iFR SWEDEHEART and DEFINE FLAIR
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Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrom, Thomas, Christiansen, Evald Hoj, Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrom, Thomas, and Christiansen, Evald Hoj
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Background and Aims Guidelines recommend revascularization of intermediate epicardial artery stenosis to be guided by evidence of ischaemia. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are equally recommended. Individual 5-year results of two major randomized trials comparing FFR with iFR-guided revascularization suggested increased all-cause mortality following iFR-guided revascularization. The aim of this study was a study-level meta-analysis of the 5-year outcome data in iFR-SWEDEHEART (NCT02166736) and DEFINE-FLAIR (NCT02053038).Methods Composite of major adverse cardiovascular events (MACE) and its individual components [all-cause death, myocardial infarction (MI), and unplanned revascularisation] were analysed. Raw Kaplan-Meier estimates, numbers at risk, and number of events were extracted at 5-year follow-up and analysed using the ipdfc package (Stata version 18, StataCorp, College Station, TX, USA).Results In total, iFR and FFR-guided revascularization was performed in 2254 and 2257 patients, respectively. Revascularization was more often deferred in the iFR group [n = 1128 (50.0%)] vs. the FFR group [n = 1021 (45.2%); P = .001]. In the iFR-guided group, the number of deaths, MACE, unplanned revascularization, and MI was 188 (8.3%), 484 (21.5%), 235 (10.4%), and 123 (5.5%) vs. 143 (6.3%), 420 (18.6%), 241 (10.7%), and 123 (5.4%) in the FFR group. Hazard ratio [95% confidence interval (CI)] estimates for MACE were 1.18 [1.04; 1.34], all-cause mortality 1.34 [1.08; 1.67], unplanned revascularization 0.99 [0.83; 1.19], and MI 1.02 [0.80; 1.32].Conclusions Five-year all-cause mortality and MACE rates were increased with revascularization guided by iFR compared to FFR. Rates of unplanned revascularization and MI were equal in the two groups. Structured Graphical Abstract Instantaneous wave-free ratio (iFR) is a non-hyperaemic pressure index measured in the wave-free period in diastole. Fractional flow reserve (FFR) is the ratio between, Funding Agencies|None.
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- 2023
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28. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with ST-Elevation Myocardial Infarction and Its Association with Acute Kidney Injury and Mortality
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Højagergaard, Mathias Alexander, Beske, Rasmus Paulin, Hassager, Christian, Holmvang, Lene, Jensen, Lisette Okkels, Shacham, Yacov, Meyer, Martin Abild Stengaard, Moeller, Jacob Eifer, Helgestad, Ole Kristian Lerche, Mark, Peter Dall, Møgelvang, Rasmus, Frydland, Martin, Højagergaard, Mathias Alexander, Beske, Rasmus Paulin, Hassager, Christian, Holmvang, Lene, Jensen, Lisette Okkels, Shacham, Yacov, Meyer, Martin Abild Stengaard, Moeller, Jacob Eifer, Helgestad, Ole Kristian Lerche, Mark, Peter Dall, Møgelvang, Rasmus, and Frydland, Martin
- Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured in 1624 (86%) on admission and in a consecutive subgroup at 6–12 h (n = 163) and 12–24 h (n = 222) after admission, this study aimed to evaluate the prognostic value of NGAL in predicting AKI and mortality. Patients were stratified based on whether their admission NGAL plasma concentration was greater than or equal to/less than the median. The primary endpoint was a composite of the first occurrence of AKI or all-cause death within 30 days. AKI was classified by the maximal plasma creatinine increase from baseline during index admission as KDIGO1 (<200% increase) or KDIGO23 (≥200% increase) according to the Kidney Disease Improving Global Outcomes (KDIGO) system. Admission NGAL > the median was independently associated with a higher risk of severe AKI (KDIGO2-3) and 30-day all-cause mortality when adjusted for age, admission systolic blood pressure and high-sensitivity C-reactive protein, left-ventricular ejection fraction, known kidney dysfunction, and cardiogenic shock with an odds ratio (95% confidence interval) of 2.26 (1.18–4.51), p = 0.014. Finally, we observed increasing predictive values in a subgroup during the first day of hospitalization suggesting that assessment of NGAL should be delayed for optimal prognostic purposes., Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured in 1624 (86%) on admission and in a consecutive subgroup at 6–12 h (n = 163) and 12–24 h (n = 222) after admission, this study aimed to evaluate the prognostic value of NGAL in predicting AKI and mortality. Patients were stratified based on whether their admission NGAL plasma concentration was greater than or equal to/less than the median. The primary endpoint was a composite of the first occurrence of AKI or all-cause death within 30 days. AKI was classified by the maximal plasma creatinine increase from baseline during index admission as KDIGO1 (<200% increase) or KDIGO23 (≥200% increase) according to the Kidney Disease Improving Global Outcomes (KDIGO) system. Admission NGAL > the median was independently associated with a higher risk of severe AKI (KDIGO2-3) and 30-day all-cause mortality when adjusted for age, admission systolic blood pressure and high-sensitivity C-reactive protein, left-ventricular ejection fraction, known kidney dysfunction, and cardiogenic shock with an odds ratio (95% confidence interval) of 2.26 (1.18–4.51), p = 0.014. Finally, we observed increasing predictive values in a subgroup during the first day of hospitalization suggesting that assessment of NGAL should be delayed for optimal prognostic purposes.
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- 2023
29. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
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Team Medisch, Circulatory Health, De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura I, Quadros, Alexandre, Milewski, Marek, Scotto D'Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra Munoz, Victor, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehitola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C C, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, Team Medisch, Circulatory Health, De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura I, Quadros, Alexandre, Milewski, Marek, Scotto D'Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra Munoz, Victor, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehitola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C C, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, and Verdoia, Monica
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- 2023
30. Soluble ST2 in plasma is associated with post-procedural no-or-slow reflow after primary percutaneous coronary intervention in ST-elevation myocardial infarction
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Søndergaard, Frederik T., Beske, Rasmus P., Frydland, Martin, Møller, Jacob Eifer, Helgestad, Ole K.L., Jensen, Lisette Okkels, Holmvang, Lene, Goetze, Jens P., Engstrøm, Thomas, Hassager, Christian, Søndergaard, Frederik T., Beske, Rasmus P., Frydland, Martin, Møller, Jacob Eifer, Helgestad, Ole K.L., Jensen, Lisette Okkels, Holmvang, Lene, Goetze, Jens P., Engstrøm, Thomas, and Hassager, Christian
- Abstract
Aim The no-or-slow-reflow phenomenon after primary percutaneous coronary intervention is associated with more extensive myocardial injury in patients with ST-elevation myocardial infarction (STEMI). Soluble suppression of tumourigenicity 2 (sST2) is released in acute myocardial response to injury, and an increase in plasma level in the initial phase of STEMI is associated with increased mortality and risk of heart failure. We have therefore explored the association of pre-intervention plasma sST2 with the post-procedural no-or-slow-reflow phenomenon in patients with STEMI. Methods and results We included consecutive patients with verified STEMI from two tertiary heart centres. Blood samples were collected at admission before angiography. Post-procedural coronary flow was assessed according to thrombolysis in myocardial infarction (TIMI) classification for STEMI. Patients were divided into two groups: post-procedural TIMI 0–2 as no-or-slow reflow and TIMI 3 as normal reflow. The association between sST2 and TIMI flow was explored using multiple logistic regression. A total of 1607 patients with available TIMI flow classification were included in the analysis. Normal reflow was seen in 1520 (94.6%), while 87 (5.4%) had no-or-slow reflow. No-or-slow-reflow patients had higher all-cause 30-day mortality [10 (11%) vs. 65 (4.3%), P = 0.006]. Pre-procedural sST2 was higher in the no-or-slow-flow group [47 ng/mL, interquartile range (IQR, 33–83) vs. 39 ng/mL (IQR 29–55), P < 0.001] and was independently associated with post-procedural no-or-slow flow [two-fold sST2 increase: odds ratio 1.44 (1.15–1.78), P = 0.0012]. Conclusion In patients with STEMI, the sST2 level at admission before coronary angiography is independently associated with the post-procedural no-or-slow-reflow phenomenon., Aim The no-or-slow-reflow phenomenon after primary percutaneous coronary intervention is associated with more extensive myocardial injury in patients with ST-elevation myocardial infarction (STEMI). Soluble suppression of tumourigenicity 2 (sST2) is released in acute myocardial response to injury, and an increase in plasma level in the initial phase of STEMI is associated with increased mortality and risk of heart failure. We have therefore explored the association of pre-intervention plasma sST2 with the post-procedural no-or-slow-reflow phenomenon in patients with STEMI. Methods and results We included consecutive patients with verified STEMI from two tertiary heart centres. Blood samples were collected at admission before angiography. Post-procedural coronary flow was assessed according to thrombolysis in myocardial infarction (TIMI) classification for STEMI. Patients were divided into two groups: post-procedural TIMI 0–2 as no-or-slow reflow and TIMI 3 as normal reflow. The association between sST2 and TIMI flow was explored using multiple logistic regression. A total of 1607 patients with available TIMI flow classification were included in the analysis. Normal reflow was seen in 1520 (94.6%), while 87 (5.4%) had no-or-slow reflow. No-or-slow-reflow patients had higher all-cause 30-day mortality [10 (11%) vs. 65 (4.3%), P = 0.006]. Pre-procedural sST2 was higher in the no-or-slow-flow group [47 ng/mL, interquartile range (IQR, 33–83) vs. 39 ng/mL (IQR 29–55), P < 0.001] and was independently associated with post-procedural no-or-slow flow [twofold sST2 increase: odds ratio 1.44 (1.15–1.78), P = 0.0012]. Conclusion In patients with STEMI, the sST2 level at admission before coronary angiography is independently associated with the post-procedural no-or-slow-reflow phenomenon.
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- 2023
31. Inflammatory response by 48 h after admission and mortality in patients with acute myocardial infarction complicated by cardiogenic shock
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Kunkel, Joakim Bo, Josiassen, Jakob, Helgestad, Ole Kristian Lerche, Schmidt, Henrik, Holmvang, Lene, Jensen, Lisette Okkels, Thøgersen, Michael, Fosbøl, Emil, Ravn, Hanne Berg, Møller, Jacob Eifer, Hassager, Christian, Kunkel, Joakim Bo, Josiassen, Jakob, Helgestad, Ole Kristian Lerche, Schmidt, Henrik, Holmvang, Lene, Jensen, Lisette Okkels, Thøgersen, Michael, Fosbøl, Emil, Ravn, Hanne Berg, Møller, Jacob Eifer, and Hassager, Christian
- Abstract
Aims Cardiogenic shock (CS) is known to induce an inflammatory response. The prognostic utility of this remains unclear. To investigate the association between C-reactive protein (CRP) levels and leucocyte count and mortality in patients with acute myocardial infarction complicated by CS (AMICS). Methods and results Consecutive patients (N = 1716) admitted between 2010 and 2017 with an individually validated diagnosis of AMICS were included. The analysis was restricted to patients alive at 48 h after first medical contact and a valid CRP and leucocyte measurement at 48 ± 12 h from the first medical contact. A combined inflammatory score for each patient was computed by summing the CRP and leucocyte count z-scores to normalize the response on a standard deviation scale. Associations with mortality were analysed using a multivariable Cox proportional hazards model stratified by inflammatory response quartiles: Of the 1716 patients in the cohort, 1111 (64.7%) fulfilled inclusion criteria. The median CRP level at 48 h was 145 mg/dL [interquartile range (IQR) 96–211]. The median leucocyte count was 12.6 × 10−9/L (IQR 10.1–16.4). Patients with the highest inflammatory response (Q4) had lower median left ventricular ejection fractions and higher lactate levels at the time of diagnosis. The 30-day all-cause mortality rates were 46% in Q4 and 21% in Q1 (P < 0.001). In multivariable models, the inflammatory response remained associated with mortality [hazard ratio (HR)Q4 2.32, 95% confidence interval (CI) 1.59–3.39, P < 0.001]. The finding was also significant in AMICS patients presenting with out-of-hospital cardiac arrest following multivariable adjustment (HRQ4 3.37, 95% CI 2.02–4.64, P < 0.001). Conclusion Cardiogenic shock induces an acute inflammatory response, the severity of which is associated with mortality., Aims Cardiogenic shock (CS) is known to induce an inflammatory response. The prognostic utility of this remains unclear. To investigate the association between C-reactive protein (CRP) levels and leucocyte count and mortality in patients with acute myocardial infarction complicated by CS (AMICS). Methods and results Consecutive patients (N = 1716) admitted between 2010 and 2017 with an individually validated diagnosis of AMICS were included. The analysis was restricted to patients alive at 48 h after first medical contact and a valid CRP and leucocyte measurement at 48 ± 12 h from the first medical contact. A combined inflammatory score for each patient was computed by summing the CRP and leucocyte count z-scores to normalize the response on a standard deviation scale. Associations with mortality were analysed using a multivariable Cox proportional hazards model stratified by inflammatory response quartiles: Of the 1716 patients in the cohort, 1111 (64.7%) fulfilled inclusion criteria. The median CRP level at 48 h was 145 mg/dL [interquartile range (IQR) 96–211]. The median leucocyte count was 12.6 × 10-9/L (IQR 10.1–16.4). Patients with the highest inflammatory response (Q4) had lower median left ventricular ejection fractions and higher lactate levels at the time of diagnosis. The 30-day all-cause mortality rates were 46% in Q4 and 21% in Q1 (P < 0.001). In multivariable models, the inflammatory response remained associated with mortality [hazard ratio (HR)Q4 2.32, 95% confidence interval (CI) 1.59–3.39, P < 0.001]. The finding was also significant in AMICS patients presenting with out-of-hospital cardiac arrest following multivariable adjustment (HRQ4 3.37, 95% CI 2.02–4.64, P < 0.001). Conclusion Cardiogenic shock induces an acute inflammatory response, the severity of which is associated with mortality.
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- 2023
32. Self-reported health and adverse outcomes among women living with symptoms of angina or unspecific chest pain but no diagnosis of obstructive coronary artery disease—findings from the DenHeart study
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Dalsgaard, Jane Lange, Hansen, Michael Skov, Thrysoee, Lars, Ekholm, Ola, Thorup, Charlotte Brun, Mols, Rikke Elmose, Rasmussen, Trine Bernholdt, Christensen, Anne Vinggaard, Pedersen, Andreas Kristian, Berg, Selina Kikkenborg, Jensen, Lisette Okkels, Mogensen, Christian Backer, Borregaard, Britt, Dalsgaard, Jane Lange, Hansen, Michael Skov, Thrysoee, Lars, Ekholm, Ola, Thorup, Charlotte Brun, Mols, Rikke Elmose, Rasmussen, Trine Bernholdt, Christensen, Anne Vinggaard, Pedersen, Andreas Kristian, Berg, Selina Kikkenborg, Jensen, Lisette Okkels, Mogensen, Christian Backer, and Borregaard, Britt
- Abstract
Aims The objectives were to describe differences in self-reported health at discharge between women diagnosed with angina or unspecific chest pain and investigate the association between self-reported health and adverse outcomes within 3 years. Methods and results Data from a national cohort study were used, including data from the DenHeart survey combined with 3 years of register-based follow-up. The population included two groups of women with symptoms of angina but no diagnosis of obstructive coronary artery disease at discharge (women with angina and women with unspecific chest pain). Self-reported health measured with validated instruments was combined with register-based follow-up on adverse outcomes (a composite of unplanned cardiac readmissions, revascularization, or all-cause mortality). Associations between self-reported health and time to first adverse outcomes were investigated with Cox proportional hazard models, reported as hazards ratios with 95% confidence intervals. In total, 1770 women completed the questionnaire (49%). Women with angina (n = 931) reported significantly worse self-reported health on several outcomes compared to women with unspecific chest pain (n = 839). Within the 3 years follow-up, women with angina were more often readmitted (29 vs. 23%, P = 0.011) and more underwent revascularization (10 vs. 1%, P < 0.001), whereas mortality rates were similar (4 vs. 4%, P = 0.750). Self-reported health (physical and mental) was associated with adverse outcomes between both groups (on most instruments). Conclusion Women with angina reported significantly worse self-reported health on most instruments compared to women with unspecific chest pain. Adverse outcomes varied between groups, with women diagnosed with angina experiencing more events.
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- 2023
33. Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H24 Analysis
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Bougherbal, Rachid, Bouafia, Mohamed Tahar, Chettibi, Mohamed, Nibouche, Djamaleddine, Moklati, Abdelkader, Benalia, Ahmed, Kaid, Omar, Krim, Messaad, Hammett, Christopher, Garrahy, Paul, Jayasinghe, Rohan, Rashford, Stephen, Huber, Kurt, Neunteufl, Thomas, Brussee, Helmut, Alber, Hannes, Weidinger, Franz, Brunner, Michael, Sipoetz, Johann, Prause, Gerhard, Baubin, Michael, Sebald, Dieter, Cantor, Warren, Vijayaraghavan, Ram, Bata, Iqbal, Lavoie, Andrea, Lassen, Jens Flensted, Ravkilde, Jan, Jensen, Lisette Okkels, Christensen, Alf Møl, Toftegaard, Marianne, Köhler, Dennis, Montalescot, Gilles, Ducrocq, Gregory, Danchin, Nicolas, Henry, Patrick, Livarek, Bernard, Berthier, Romain, Hovasse, Thomas, Garot, Philippe, Payot, Laurent, Benamer, Hakim, Esteve, Jean Baptiste, Elhadad, Simon, Teiger, Emmanuel, Bonnet, Jean Louis, Paganelli, Franck, Cottin, Yves, Schiele, François, Thuaire, Christophe, Cayla, Guillaume, Coste, Pierre, Ohlmann, Patrick, Cudraz, Eric Bonnefoy, Lantelme, Pierre, Perret, Thibault, Tron, Christophe, De Labriolle, Axel, Aptecar, Edouardo, Beliard, Olivier, Varenne, Olivier, El Mahmoud, Rami, Filippi-Codaccioni, Emmanuelle, Angoulvant, Denis, Peycher, Patrick, Poitrineau, Olivier, Tabone, Xavier, Ecollan, Patrick, Broche, Claire, Lambert, Yves, Briole, Nicolas, Beruben, Arielle, Porcher, Nicolas, Auffray, Jean-Pierre, Freysz, Marc, Depardieu, Franck, Poubel, David, De La Cousaye, Jean-Emmanuel, Bartier, Jean-Claude, Jardel, Benoît, Boulanger, Bertrand, Labourel, Hervé, Soulat, Louis-Christophe, Lapostolle, Frédéric, Julie, Véronique, Thicoipe, Michel, Capel, Olivier, Stibbe, Olivier, Carli, Pierre, Tazarourte, Karim, Alcouffe, Fabrice, Aboucaya, David, Aubert, Gaële, Kierzek, Gérald, Cahun-Giraud, Séverine, Zeymer, Uwe, Hamm, Christian, Dengler, Thomas, Prondzinsky, Roland, Biever, Paul Marc, Schäfer, Andreas, Seyfarth, Melchior, Lemke, Bernd, Werner, Gerald, Nef, Holger, Steiger, Holger, Leschke, Matthias, Münzel, Thomas, Dell Orto, Marco Campo, Loges, Christian, Schinke, Monika, Koberne, Frank, Reiffen, Hans Peter, Tiroch, Klaus, Wierich, Dirk, Kneussel, Michael, Little, Simon, Sauer, Hartmut, Laufenberg-Feldmann, Rita, Merkely, Béla, Ungi, Imre, Horváth, Iván, Édes, István, Mártai, István, Bolognese, Leonardo, Berti, Sergio, Chiarella, Francesco, Calabria, Paolo, Fineschi, Massimo, Galvani, Marcello, Valgimigli, Marco, Moretti, Luciano, Tespili, Maurizio, Mandó, Massimo, Bermano, Francesco, Biagioni, Robusto, Fabbri, Andrea, Ricciardelli, Adelina, Petroni, Maria Romana, Vatteroni, Umberto Roberto, Palumbo, Francesco, Willems, Frank F., Al Mafragi, Amar, Heestermans, Ton A.A.C.M., Van Eck, Martijn J., Heutz, Wim M.J.M., Meppelder, H.H., Jong, Anika Roukema-de, Van de Pas, Harm, Fillat, Ángel Cequier, Tenas, Manel Sabaté, Ferrer, Josepa Mauri, Peñaranda, Antoni Serra, Ferrer, Joan Ángel, Del Blanco, Bruno García, Guardiola, Faustino Miranda, Ruiz Nodar, Juan Miguel, Romo, Andrés Íñiguez, González, Nicolás Vázquez, Nouche, Ramiro Trillo, De La Llera, Luis Díaz, Hernández García, José María, Rivero-Crespo, Fernando, Hernández, Felipe Hernández, Zamorano Gómez, José Luis, Fárega, Xavier Jiménez, Fernández, Gilberto Alonso, Toboso, José Luis, Carrasco, Mercedes, Barreiro, Victoria, Iglesias Vázquez, José Antonio, Montero, María del Mar Ruiz, Ortiz, Fernando Rosell, Escudero, Guillermo Garcia, Ingelmo, Vicente Sánchez-Brunete, García, Antonio Lara, Janzon, Magnus, Oldgren, Jonas, Calais, Fredrik, Kastberg, Robert, Bergsten, Per-Adolf, Blomberg, Hans, Thörn, Kristian, Skoog, Gunnar, Storey, Robert F., Zaman, Azfar, Gerber, Robert, Ryding, Alisdair, Spence, Mark, Swanson, Neil, Been, Martin, Grosser, Konrad, Schofield, Peter, Mackin, David, Fell, Paul, Quinn, Tom, Foster, Teresa, McManus, David, Carson, Andy, van ’t Hof, Arnoud W., Cantor, Warren J., Cequier, Angel, Collet, Jean-Philippe, Goodman, Shaun G., Hammett, Christopher J., Licour, Muriel, Salhi, Néjoua, Silvain, Johanne, ten Berg, Jurriën M., Tsatsaris, Anne, Vicaut, Eric, and Hamm, Christian W.
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- 2016
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34. Results of the ISACS-STEMI COVID-19 Registry
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De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra Munoz, Victor, Lee, Michael Kang yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehitola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C.C., Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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ST-segment elevation myocardial infarction ,Medicine(all) ,ageing ,COVID-19 - Abstract
Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. publishersversion published
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- 2023
35. Lactate is a Prognostic Factor in Patients Admitted With Suspected ST-Elevation Myocardial Infarction
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Frydland, Martin, Møller, Jacob Eifer, Wiberg, Sebastian, Lindholm, Matias Greve, Hansen, Rikke, Henriques, Jose P.S., Møller-Helgestad, Ole Kristian, Bang, Lia Evi, Frikke-Schmidt, Ruth, Goetze, Jens Peter, Udesen, Nanna Louise Junker, Thomsen, Jakob Hartvig, Ouweneel, Dagmar M., Obling, Laust, Ravn, Hanne Berg, Holmvang, Lene, Jensen, Lisette Okkels, Kjaergaard, Jesper, and Hassager, Christian
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- 2019
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36. Five-Year Clinical Outcome of the Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Stent Compared to the Biodegradable Polymer Biolimus-Eluting Stent in Patients Treated With Percutaneous Coronary Intervention: From the SORT OUT VII Trial
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Hansen, Kirstine Nørregaard, primary, Jensen, Lisette Okkels, additional, Maeng, Michael, additional, Christensen, Martin Kirk, additional, Noori, Manijeh, additional, Kahlert, Johnny, additional, Jakobsen, Lars, additional, Junker, Anders, additional, Freeman, Phillip, additional, Ellert-Gregersen, Julia, additional, Raungaard, Bent, additional, Terkelsen, Christian Juhl, additional, Veien, Karsten Tange, additional, and Christiansen, Evald Høj, additional
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- 2023
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37. Plasma Concentration of Biomarkers Reflecting Endothelial Cell- and Glycocalyx Damage are Increased in Patients With Suspected ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock
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Frydland, Martin, Ostrowski, Sisse Rye, Møller, Jacob Eifer, Hadziselimovic, Edina, Holmvang, Lene, Ravn, Hanne Berg, Jensen, Lisette Okkels, Pettersson, Anna Sina, Kjaergaard, Jesper, Lindholm, Matias Greve, Johansson, Pär Ingemar, and Hassager, Christian
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- 2018
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38. Influence of cardiogenic shock with or without the use of intra-aortic balloon pump on mortality in patients with ST-segment elevation myocardial infarction
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Jensen, Jesper Khedri, Thayssen, Per, Antonsen, Lisbeth, Hougaard, Mikkel, Junker, Anders, Pedersen, Knud Erik, and Jensen, Lisette Okkels
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- 2015
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39. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI
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De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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Medicine(all) ,myocardial infarction ,percutaneous coronary intervention ,COVID-19 ,smoking paradox - Abstract
Publisher Copyright: © 2022 by the authors. The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history. publishersversion published
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- 2022
40. Vasoactive pharmacological management according to SCAI class in patients with acute myocardial infarction and cardiogenic shock
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Udesen, Nanna Louise Junker, primary, Helgestad, Ole Kristian Lerche, additional, Josiassen, Jakob, additional, Hassager, Christian, additional, Højgaard, Henrik Frederiksen, additional, Linde, Louise, additional, Kjaergaard, Jesper, additional, Holmvang, Lene, additional, Jensen, Lisette Okkels, additional, Schmidt, Henrik, additional, Ravn, Hanne Berg, additional, and Møller, Jacob Eifer, additional
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- 2022
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41. Three-Year Outcomes After Revascularization With Everolimus- and Sirolimus-Eluting Stents From the SORT OUT IV Trial
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Jensen, Lisette Okkels, Thayssen, Per, Maeng, Michael, Christiansen, Evald Høj, Ravkilde, Jan, Hansen, Knud Nørregaard, Kaltoft, Anne, Tilsted, Hans Henrik, Madsen, Morten, and Lassen, Jens Flensted
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- 2014
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42. Impact of diabetes on long-term all-cause re-hospitalization after revascularization with percutaneous coronary intervention
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Hansen, Kirstine N, primary, Noori, Manijeh, additional, Christiansen, Evald H, additional, Kristiansen, Eskild B, additional, Maeng, Michael, additional, Zwisler, Ann Dorthe O, additional, Borregaard, Britt, additional, Søgaard, Rikke, additional, Veien, Karsten T, additional, Junker, Anders, additional, and Jensen, Lisette Okkels, additional
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- 2022
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43. Impact of diabetes on 1-year clinical outcome in patients undergoing revascularization with the BioFreedom stents or the Orsiro stents from the SORT OUT IX trial
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Hansen, Kirstine Nørregaard, Maeng, Michael, Raungaard, Bent, Engstrøm, Thomas, Veien, Karsten Tange, Kristensen, Steen Dalby, Ellert-Gregersen, Julia, Jensen, Svend Eggert, Junker, Anders, Kahlert, Johnny, Jakobsen, Lars, Christiansen, Evald Høj, Jensen, Lisette Okkels, Hansen, Kirstine Nørregaard, Maeng, Michael, Raungaard, Bent, Engstrøm, Thomas, Veien, Karsten Tange, Kristensen, Steen Dalby, Ellert-Gregersen, Julia, Jensen, Svend Eggert, Junker, Anders, Kahlert, Johnny, Jakobsen, Lars, Christiansen, Evald Høj, and Jensen, Lisette Okkels
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This sub-study of the SORT OUT IX trial sought to compare clinical outcomes between patients with diabetes randomized to implantation of either the polymer-free biolimus A9-coated BioFreedom stent (BF-BES) or the ultra-thin strut, biodegradable polymer sirolimus-eluting Orsiro stent (O-SES). Patients with diabetes have an increased risk of target lesion failure (TLF) after percutaneous coronary intervention (PCI). The impact of different stent types in patients with diabetes is still discussed. A total of 607 of the 3151 patients (19.3%) enrolled in the SORT OUT IX study had diabetes. Randomization was stratified by patients with/without diabetes; 304 received BF-BES and 303 O-SES. The primary endpoint was TLF, which was a composite of cardiac death, myocardial infarction (not related to other than the index lesion) and target lesion revascularization (TLR) within 1 year. After 1 year, patients with diabetes had higher TLF (7.2% vs. 3.7%, incidence rate ratio [IRR]: 1.65; 95% confidence interval [CI]: 1.08–2.50), than patients without diabetes. TLF did not differ significantly between BF-BES and O-SES in patients with diabetes (8.2% vs. 6.3%, IRR: 1.17; 95% CI: 0.63–2.20). In patients with diabetes, cardiac death occurred in 2.3% of BF-BES and in 3.6% of O-SES (IRR: 0.58; 95% CI: 0.23–1.45) and TLR occurred in 5.3% and 2.3% of BF-BES and O-SES, respectively (IRR: 2.12; 95% CI: 0.81–5.56). Definite stent thrombosis rates of 1.3% were found in both stent types. Patients with diabetes had higher 1-year TLF rate after PCI compared to patients without diabetes, whereas TLF did not differ significantly between the two stent types BF-BES and O-SES in patients with diabetes.
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- 2022
44. Vasoactive pharmacological management according to SCAI class in patients with acute myocardial infarction and cardiogenic shock
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Udesen, Nanna Louise Junker, Helgestad, Ole Kristian Lerche, Josiassen, Jakob, Hassager, Christian, Højgaard, Henrik Frederiksen, Linde, Louise, Kjaergaard, Jesper, Holmvang, Lene, Jensen, Lisette Okkels, Schmidt, Henrik, Ravn, Hanne Berg, Møller, Jacob Eifer, Udesen, Nanna Louise Junker, Helgestad, Ole Kristian Lerche, Josiassen, Jakob, Hassager, Christian, Højgaard, Henrik Frederiksen, Linde, Louise, Kjaergaard, Jesper, Holmvang, Lene, Jensen, Lisette Okkels, Schmidt, Henrik, Ravn, Hanne Berg, and Møller, Jacob Eifer
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Background Vasoactive treatment is a cornerstone in treating hypoperfusion in cardiogenic shock following acute myocardial infarction (AMICS). The purpose was to compare the achievement of treatment targets and outcome in relation to vasoactive strategy in AMICS patients stratified according to the Society of Cardiovascular Angiography and Interventions (SCAI) shock classification. Methods Retrospective analysis of patients with AMICS admitted to cardiac intensive care unit at two tertiary cardiac centers during 2010–2017 with retrieval of real-time hemodynamic data and dosages of vasoactive drugs from intensive care unit databases. Results Out of 1,249 AMICS patients classified into SCAI class C, D, and E, mortality increased for each shock stage from 34% to 60%, and 82% (p<0.001). Treatment targets of mean arterial blood pressure > 65mmHg and venous oxygen saturation > 55% were reached in the majority of patients; however, more patients in SCAI class D and E had values below treatment targets within 24 hours (p<0.001) despite higher vasoactive load and increased use of epinephrine for each severity stage (p<0.001). In univariate analysis no significant difference in mortality within SCAI class D and E regarding vasoactive strategy was observed, however in SCAI class C, epinephrine was associated with higher mortality and a significantly higher vasoactive load to reach treatment targets. In multivariate analysis there was no statistically association between individually vasoactive choice within each SCAI class and 30-day mortality. Conclusion Hemodynamic treatment targets were achieved in most patients at the expense of increased vasoactive load and more frequent use of epinephrine for each shock severity stage. Mortality was high regardless of vasoactive strategy; only in SCAI class C, epinephrine was associated with a significantly higher mortality, but the signal was not significant in adjusted analysis.
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- 2022
45. Polymer-free biolimus-coated stents versus ultrathin-strut biodegradable polymer sirolimus-eluting stents:two-year outcomes of the randomised SORT OUT IX trial
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Ellert-Gregersen, Julia, Jensen, Lisette Okkels, Jakobsen, Lars, Freeman, Phillip Michael, Eftekhari, Ashkan, Maeng, Michael, Raungaard, Bent, Engstroem, Thomas, Kahlert, Johnny, Hansen, Henrik Steen, Christiansen, Evald Høj, Ellert-Gregersen, Julia, Jensen, Lisette Okkels, Jakobsen, Lars, Freeman, Phillip Michael, Eftekhari, Ashkan, Maeng, Michael, Raungaard, Bent, Engstroem, Thomas, Kahlert, Johnny, Hansen, Henrik Steen, and Christiansen, Evald Høj
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Background: For patients with high bleeding risk, the BioFreedom stent is safer and more effective than a bare metal stent. However, at the one-year follow-up of the SORT OUT IX trial, the BioFreedom stent did not meet the criteria for non-inferiority for target lesion failure (TLF) when compared with the Orsiro stent and had a higher incidence of target lesion revascularisation (TLR). Aims: The aim of the study was to compare the two-year outcomes following coronary implantation of the BioFreedom or the Orsiro stents in all-comer patients. Methods: The Scandinavian Organization for Randomized Trials with Clinical Outcome (SORT OUT) IX trial is a prospective, multicentre, randomised clinical trial comparing the BioFreedom and the Orsiro stents. The primary endpoint, TLF, was a composite of cardiac death, myocardial infarction (MI; not related to other lesions) and TLR. Results: A total of 1,572 patients were randomised to treatment with the BioFreedom stent and 1,579 patients with the Orsiro stent. At two-year follow-up, TLF was 7.8% in the BioFreedom and 6.3% in the Orsiro stent groups (rate ratio [RR] 1.23, 95% confidence interval [CI]: 0.94-1.61). Risks of cardiac death, MI and definite stent thrombosis did not differ significantly between the groups, whereas more patients in the BioFreedom group had TLR (5.1% vs 2.6%; RR 1.98, 95% CI: 1.26-2.89) attributable to a higher risk of TLR within the first year (3.5% vs 1.3%; RR 2.77, 95% CI: 1.66-4.62). Conclusions: At two years, there were no significant differences between the BioFreedom and Orsiro stents for TLF. TLR was significantly higher with the BioFreedom stent due to higher risk of TLR within the first year.
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- 2022
46. Timing and Causes of Death in Acute Myocardial Infarction Complicated by Cardiogenic Shock (from the RETROSHOCK Cohort)
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Davodian, Lise W., Larsen, Jeppe K. P., Povlsen, Amalie L., Josiassen, Jakob, Helgestad, Ole K. L., Udesen, Nanna L. J., Hassager, Christian, Schmidt, Henrik, Kjaergaard, Jesper, Holmvang, Lene, Jensen, Lisette Okkels, Ravn, Hanne B., Møller, Jacob E., Davodian, Lise W., Larsen, Jeppe K. P., Povlsen, Amalie L., Josiassen, Jakob, Helgestad, Ole K. L., Udesen, Nanna L. J., Hassager, Christian, Schmidt, Henrik, Kjaergaard, Jesper, Holmvang, Lene, Jensen, Lisette Okkels, Ravn, Hanne B., and Møller, Jacob E.
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Acute myocardial infarction complicated by cardiogenic shock (AMICS) comprises a heterogeneous population with high mortality. Insight in timing and cause of death may improve understanding of the condition and aid individualization of treatment. This was assessed in a retrospective, multicenter observational cohort study based on 1,716 patients with AMICS treated during the period of 2010 to 2017, of whom 904 died before hospital discharge. Patients with AMICS were identified through national registries and review of individual patients charts. In 904 patients with AMICS who died before hospital discharge (median age 72 years [interquartile range (IQR) 63 to 79], 70% men), 342 (38%) had suffered out-of-hospital cardiac arrest. The most frequent cause of death was primary cardiac (54%), whereas 24% died of neurologic injury, and 20% of multiorgan failure (MOF). Time to death was 13 hours (IQR 5 to 43) for heart failure; 140 hours (IQR 95 to 209) in neurologic injury; and 137 hours (IQR 59 to 321) in MOF, p <0.001. The causes of death in patients presenting with out-of-hospital cardiac arrest (OHCA) were: neurologic injury in 57%, as opposed to 4% in patients not presenting with OHCA, p <0.001. In conclusion, in patients with AMICS, cause of death was mainly primary heart failure followed by neurologic injury and MOF. Median time from first medical contact to death was only 13 hours in patients dying from cardiac causes. The risk of dying of neurologic injury was low in patients without OHCA.
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- 2022
47. Use of Helicopters to Reduce Health Care System Delay in Patients With ST-Elevation Myocardial Infarction Admitted to an Invasive Center
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Mørk, Sivagowry Rasalingam, Bøtker, Morten Thingemann, Hjort, Jakob, Jensen, Lisette Okkels, Pedersen, Frants, Jørgensen, Gitte, Christensen, Erika Frischknect, Christensen, Marina Krintel, Aarø, Jens, Lippert, Freddy, Knudsen, Lars, Hansen, Troels Martin, Steinmetz, Jacob, Terkelsen, Christian Juhl, Mørk, Sivagowry Rasalingam, Bøtker, Morten Thingemann, Hjort, Jakob, Jensen, Lisette Okkels, Pedersen, Frants, Jørgensen, Gitte, Christensen, Erika Frischknect, Christensen, Marina Krintel, Aarø, Jens, Lippert, Freddy, Knudsen, Lars, Hansen, Troels Martin, Steinmetz, Jacob, and Terkelsen, Christian Juhl
- Abstract
Timely reperfusion in ST-elevation myocardial infarction (STEMI) is essential. This study aimed to evaluate the reduction in system delay (time from emergency medical service [EMS] call to primary percutaneous coronary intervention [PPCI]) in patients with STEMI when using helicopter EMS (HEMS) rather than ground-based EMS (GEMS). This was a retrospective, nationwide cohort study of consecutive patients with STEMI treated with PPCI at 5 PPCI centers in Denmark. Polynomial spline curves were constructed to describe the association between system delay and distance to the PPCI center stratified by transportation mode. A total of 26,433 patients with STEMI were treated with PPCI between January 1, 1999, and December 31, 2016. In 16,436 patients field triaged directly to the PPCI center, the proportion treated within 120 minutes of the EMS call was 75% for those living 0 to 25 km from the PPCI center compared with 65% for all patients transported by GEMS (median transport distance 50 km [interquartile range 23 to 90]) and 64% for all patients transported by HEMS (median transport distance 119 km [interquartile range 99 to 142]). The estimated reduction in system delay owed to using HEMS rather than GEMS was 14, 16, 20, and 29 minutes for patients living 75, 100, 125, and 170 km from a PPCI center. In conclusion, this study confirmed that using HEMS ensures that most patients with STEMI, living up to 170 km from a PPCI center, can be treated within 120 minutes of their EMS call provided they are field triaged directly to the PPCI center.
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- 2022
48. Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy
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Madsen, Jasmine Melissa, Glinge, Charlotte, Jabbari, Reza, Nepper-Christensen, Lars, Hofsten, Dan Eik, Tilsted, Hans-Henrik, Holmvang, Lene, Pedersen, Frants, Joshi, Francis Richard, Sørensen, Rikke, Bang, Lia Evi, Botker, Hans Erik, Terkelsen, Christian Juhl, Maeng, Michael, Jensen, Lisette Okkels, Aaroe, Jens, Kelbaek, Henning, Torp-Pedersen, Christian, Køber, Lars, Lonborg, Jacob Thomsen, Engstrøm, Thomas, Madsen, Jasmine Melissa, Glinge, Charlotte, Jabbari, Reza, Nepper-Christensen, Lars, Hofsten, Dan Eik, Tilsted, Hans-Henrik, Holmvang, Lene, Pedersen, Frants, Joshi, Francis Richard, Sørensen, Rikke, Bang, Lia Evi, Botker, Hans Erik, Terkelsen, Christian Juhl, Maeng, Michael, Jensen, Lisette Okkels, Aaroe, Jens, Kelbaek, Henning, Torp-Pedersen, Christian, Køber, Lars, Lonborg, Jacob Thomsen, and Engstrøm, Thomas
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In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy. (C) 2021 The Author(s). Published by Elsevier Inc.
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- 2022
49. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
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Team Medisch, Circulatory Health, De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura I, Quadros, Alexandre, Milewski, Marek, Scotto D'Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, Team Medisch, Circulatory Health, De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura I, Quadros, Alexandre, Milewski, Marek, Scotto D'Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, and Verdoia, Monica
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- 2022
50. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic
- Author
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Team Medisch, Circulatory Health, De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Verdoia, Monica, Team Medisch, Circulatory Health, De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica
- Published
- 2022
Catalog
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