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1. Frobenius Divisibility and Hopf Centers

Author

Jacoby, Adam

Subjects
Mathematics - Rings and Algebras
Abstract

A classical theorem of I. Schur states that the degree of any irreducible complex representation of a finite group $G$ divides the order of $G/\mathscr{Z} G$, where $\mathscr{Z} G$ is the center $G$. This note discusses similar divisibility results for certain classes of Hopf algebras.

Published
2017

2. Frobenius Divisibility for Hopf Algebras

Author

Jacoby, Adam and Lorenz, Martin

Subjects
Mathematics - Rings and Algebras, 16G99, 16T99
Abstract

We present a unified ring theoretic approach, based on properties of the Casimir element of a symmetric algebra, to a variety of known divisibility results for the degrees of irreducible representations of semisimple Hopf algebras in characteristic 0. All these results are motivated by a classical theorem of Frobenius on the degrees of irreducible complex representations of finite groups.

Published
2015

13. Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody

Author

Gelb, Bruce E., Diaz-Siso, J. Rodrigo, Plana, Natalie M., Jacoby, Adam, Rifkin, William J., Khouri, Kimberly S., Ceradini, Daniel J., and Rodriguez, Eduardo D.

Subjects
Article Subject
Abstract

Background. Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Case Presentation. A 41-year-old male with severe disfigurement from facial burns consented to facial allotransplantation in 2014; panel reactive antibody score was 0%. In August of 2015, a suitable donor was found. Complement-dependent cytotoxicity crossmatch was negative; flow cytometry crossmatch was positive to donor B cells. An induction immunosuppression strategy consisting of rabbit antithymocyte globulin, rituximab, tacrolimus, mycophenolate mofetil (MMF), and methylprednisolone taper was designed. Total face, scalp, eyelid, ears, and skeletal subunit allotransplantation was performed without operative, immunological, or infectious complications. Maintenance immunosuppression consists of tacrolimus, MMF, and prednisone. As of posttransplant month 24, the patient has not developed acute rejection or metabolic or infectious complications. Conclusions. To our knowledge, this is the first report of targeted B cell agents used for induction immunosuppression in skin-containing vascularized composite tissue allotransplantation. A cautious approach is warranted, but early results are promising for reconstructive transplant candidates given the exceptionally high rate of acute rejection episodes, particularly in the first year, in this patient population.

Published
2018
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16. Abstract

Author

Jacoby, Adam, primary, Maliha, Samantha, additional, Granieri, Michael, additional, Zhao, Lee C., additional, and Bluebond-Langner, Rachel, additional

Published
2018
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17. Abstract

Author

Maliha, Samantha, primary, Cohen, Oriana, additional, Jacoby, Adam, additional, and Sharma, Sheel, additional

Published
2018
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18. Abstract

Author

Frey, Jordan D., primary, Jacoby, Adam, additional, Cohen, Leslie E., additional, Jacobson, Adam S., additional, and Levine, Jamie P., additional

Published
2018
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19. Abstract 141

Author

Rifkin, William J., primary, Stranix, John T., additional, Borab, Zachary M., additional, Jacoby, Adam, additional, Lee, Z-Hye, additional, Anzai, Lavinia, additional, Ceradini, Daniel J., additional, Thanik, Vishal, additional, Saadeh, Pierre B., additional, and Levine, Jamie P., additional

Published
2018
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20. Abstract 19

Author

Stranix, John T., primary, Lee, Z-Hye, additional, Jacoby, Adam, additional, Anzai, Lavinia, additional, Ricci, Joseph, additional, Rifkin, William J., additional, Avraham, Tomer, additional, Thanik, Vishal D., additional, Saadeh, Pierre B., additional, and Levine, Jamie P., additional

Published
2018
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21. Abstract QS10

Author

Ricci, Joseph A., primary, Stranix, John T., additional, Lee, Z-Hye, additional, Jacoby, Adam, additional, Anzai, Lavinia, additional, Thanik, Vishal, additional, Saadeh, Pierre, additional, and Levine, Jamie P., additional

Published
2018
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22. Abstract 42

Author

Manjunath, Amit K., primary, Kantar, Rami S., additional, Cammarata, Michael J., additional, Jacoby, Adam, additional, Rifkin, William J., additional, Gelb, Bruce E., additional, Diaz-Siso, Rodrigo, additional, and Rodriguez, Eduardo D., additional

Published
2018
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23. Abstract 106

Author

Stranix, John T., primary, Anzai, Lavinia, additional, Lee, Z-Hye, additional, Jacoby, Adam, additional, Saadeh, Pierre B., additional, Thanik, Vishal D., additional, and Levine, Jamie P., additional

Published
2017
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24. Rate constants for reaction of CH2FCH2F (HFC-152) and CH3CHF2 (HFC-152a) with hydroxyl radicals

Author

Wilson, Edmond W., Jr., Jacoby, Adam M., Kukta, Sheila J., Gilbert, Lauren E., and DeMore, William B.

Subjects
Radicals (Chemistry) -- Research, Chemical reactions -- Research, Hydrocarbons -- Research, Chemicals, plastics and rubber industries
Abstract

A relative rate method is used to measure the rates of reaction, Arrhenius preexponential factors, and activation energies of CH2FCH2F (HFC-152) and CH3CHF2 (HFC-152a) for the abstraction reaction with hydroxyl radicals. For both reactants, uncertainties in k(298 K) and E/R are believed to be less than 10 percent and 100 K respectively.

Published
2003

25. Abstract

Author

Weinreb, Ross H., primary, Morrison, Kerry A., additional, Jin, Julia, additional, Dong, Xue, additional, Toyoda, Yoshiko, additional, Jacoby, Adam, additional, Mukherjee, Sushmita, additional, and Spector, Jason A., additional

Published
2016
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26. Abstract

Author

Stranix, John T., primary, Jacoby, Adam, additional, Rapp, Timothy, additional, and Saadeh, Pierre B., additional

Published
2016
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27. Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis

Author

Corbalan,J Jose, Medina,Carlos, Jacoby,Adam, Malinski,Tadeusz, Radomski,Marek W, Corbalan,J Jose, Medina,Carlos, Jacoby,Adam, Malinski,Tadeusz, and Radomski,Marek W

Abstract

J Jose Corbalan1,2, Carlos Medina1, Adam Jacoby2, Tadeusz Malinski2, Marek W Radomski11School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Ireland; 2Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USABackground: Amorphous silica nanoparticles (SiNP) can be used in medical technologies and other industries leading to human exposure. However, an increased number of studies indicate that this exposure may result in cardiovascular inflammation and damage. A high ratio of nitric oxide to peroxynitrite concentrations ([NO]/[ONOO-]) is crucial for cardiovascular homeostasis and platelet hemostasis. Therefore, we studied the influence of SiNP on the platelet [NO]/[ONOO-] balance and platelet aggregation.Methods: Nanoparticle–platelet interaction was examined using transmission electron microscopy. Electrochemical nanosensors were used to measure the levels of NO and ONOO- released by platelets upon nanoparticle stimulation. Platelet aggregation was studied using light aggregometry, flow cytometry, and phase contrast microscopy.Results: Amorphous SiNP induced NO release from platelets followed by a massive stimulation of ONOO- leading to an unfavorably low [NO]/[ONOO-] ratio. In addition, SiNP induced an upregulation of selectin P expression and glycoprotein IIb/IIIa activation on the platelet surface membrane, and led to platelet aggregation via adenosine diphosphate and matrix metalloproteinase 2-dependent mechanisms. Importantly, all the effects on platelet aggregation were inversely proportional to nanoparticle size.Conclusions: The exposure of platelets to amorphous SiNP induces a critically low [NO]/[ONOO-] ratio leading to platelet aggregation. These findings provide new insights into the pharmacological profile of SiNP in platelets.Keywords: amorphous silica nanoparticles, nanotoxicology, nitric oxide, peroxynitrite, platelet aggregation

Published
2012

28. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects

Author

Corbalan,J Jose, Medina,Carlos, Jacoby,Adam, Malinski,Tadeusz, Radomski,Marek W, Corbalan,J Jose, Medina,Carlos, Jacoby,Adam, Malinski,Tadeusz, and Radomski,Marek W

Abstract

J Jose Corbalan1,2, Carlos Medina1, Adam Jacoby2, Tadeusz Malinski2, Marek W Radomski11School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland; 2Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USABackground: The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells.Methods: Nanoparticle uptake was examined by transmission electron microscopy. Electrochemical nanosensors were used to measure the nitric oxide (NO) and peroxynitrite (ONOO-) released by a single cell upon nanoparticle stimulation. The downstream inflammatory effects were measured by an enzyme-linked immunosorbent assay, real-time quantitative polymerase chain reaction, and flow cytometry, and cytotoxicity was measured by lactate dehydrogenase assay.Results: We found that the silica nanoparticles penetrated the plasma membrane and rapidly stimulated release of cytoprotective NO and, to a greater extent, production of cytotoxic ONOO-. The low [NO]/[ONOO-] ratio indicated increased nitroxidative/oxidative stress and correlated closely with endothelial inflammation and necrosis. This imbalance was associated with nuclear factor κB activation, upregulation of key inflammatory factors, and cell death. These effects were observed in a nanoparticle size-dependent and concentration-dependent manner.Conclusion: The [NO]/[ONOO-] imbalance induced by amorphous silica nanoparticles indicates a potentially deleterious effect of silica nanoparticles on vascular endothelium.Keywords: amorphous silica nanoparticles, nanotoxicology, nitric oxide, peroxynitrite, inflammation, risk factors

Published
2011

39. LETTERS.

Author

Fairchild, Shannon, Boersch, Gloria, Savcic, Maja, Blanchard, Gale, Freeland, Lauren, Good, Wendy Van Wyck, Parker, Patrick, Ames, Christine Caldwell, Liaci, Stephanie, Badell, Colleen C., Duffty, Keanan, Morris, Daniel, Taylor, Noel, Dayton, John Philip, Bonelli, John, Moffitt, Peggy, Tabor, Jerilyn, Rosen, Yosef, Jacoby, Adam, and Ruble, A.

Subjects
LETTERS to the editor, IMPERIALISM, LATIN America-United States relations
Abstract

The article presents letters to the editor is response to articles in the October 2006 issue, including "Someone Wanted to See Me?," by Jane Sarkin, "Empire Falls," by Niall Ferguson, and "Pox Americana," by Michael Wolff.

Published
2006

42. Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody

Author

E. Gelb, Bruce, Rodrigo Diaz-Siso, J., M. Plana, Natalie, Jacoby, Adam, J. Rifkin, William, S. Khouri, Kimberly, J. Ceradini, Daniel, and D. Rodriguez, Eduardo

Abstract

Background. Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Case Presentation. A 41-year-old male with severe disfigurement from facial burns consented to facial allotransplantation in 2014; panel reactive antibody score was 0%. In August of 2015, a suitable donor was found. Complement-dependent cytotoxicity crossmatch was negative; flow cytometry crossmatch was positive to donor B cells. An induction immunosuppression strategy consisting of rabbit antithymocyte globulin, rituximab, tacrolimus, mycophenolate mofetil (MMF), and methylprednisolone taper was designed. Total face, scalp, eyelid, ears, and skeletal subunit allotransplantation was performed without operative, immunological, or infectious complications. Maintenance immunosuppression consists of tacrolimus, MMF, and prednisone. As of posttransplant month 24, the patient has not developed acute rejection or metabolic or infectious complications. Conclusions. To our knowledge, this is the first report of targeted B cell agents used for induction immunosuppression in skin-containing vascularized composite tissue allotransplantation. A cautious approach is warranted, but early results are promising for reconstructive transplant candidates given the exceptionally high rate of acute rejection episodes, particularly in the first year, in this patient population.

Published
2018
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