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1. Grand Rounds

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G. Fayolle, W. Levick, R. Lajiness-O'Neill, P. Fastenau, S. Briskin, N. Bass, M. Silva, E. Critchfield, R. Nakase-Richardson, J. Hertza, A. Loughan, R. Perna, S. Northington, S. Boyd, A. Anderson, S. Peery, M. Chafetz, M. Maris, A. Ramezani, C. Sylvester, K. Goldberg, M. Constantinou, M. Karekla, J. Hall, M. Edwards, V. Balldin, A. Strutt, V. Pavlik, C. Marquez de la Plata, M. Cullum, l. lacritz, J. Reisch, P. Massman, D. Royall, R. Barber, S. Younes, A. Wiechmann, S. O'Bryant, K. Patel, J. Suhr, S. Chari, J. Yokoyama, B. Bettcher, A. Karydas, B. Miller, J. Kramer, R. Zec, S. Fritz, S. Kohlrus, R. Robbs, T. Ala, K. Gifford, N. Cantwell, R. Romano, A. Jefferson, A. Holland, S. Newton, J. Bunting, M. Coe, J. Carmona, D. Harrison, A. Puente, D. Terry, C. Faraco, C. Brown, A. Patel, A. Watts, A. Kent, J. Siegel, S. Miller, W. Ernst, G. Chelune, J. Holdnack, J. Sheehan, K. Duff, O. Pedraza, J. Crawford, L. Miller, V. Hobson Balldin, H. Benavides, L. Johnson, L. Tshuma, N. Dezhkam, L. Hayes, C. Love, B. Stephens, F. Webbe, K. Mulligan, K. Dunham, S. Shadi, C. Sofko, R. Denney, S. Rolin, J. Sibson, S. Ogbeide, M. Glover, A. Warchol, B. Hunter, C. Nichols, C. Riccio, M. Cohen, A. Dennison, T. Wasserman, S. Schleicher-Dilks, M. Adler, C. Golden, T. Olivier, B. LeMonda, J. McGinley, A. Pritchett, L. Chang, C. Cloak, E. Cunningham, G. Lohaugen, J. Skranes, T. Ernst, E. Parke, N. Thaler, L. Etcoff, D. Allen, P. Andrews, S. McGregor, R. Daniels, N. Hochsztein, E. Miles-Mason, Y. Granader, M. Vasserman, W. MacAllister, B. Casto, K. Patrick, F. Hurewitz, D. Chute, A. Booth, C. Koch, G. Roid, N. Balkema, J. Kiefel, L. Bell, A. Maerlender, T. Belkin, J. Katzenstein, C. Semerjian, V. Culotta, E. Band, R. Yosick, T. Burns, A. Arenivas, D. Bearden, K. Olson, K. Jacobson, S. Ubogy, C. Sterling, E. Taub, A. Griffin, T. Rickards, G. Uswatte, D. Davis, K. Sweeney, A. Llorente, A. Boettcher, B. Hill, D. Ploetz, J. Kline, M. Rohling, J. O'Jile, K. Holler, V. Petrauskas, J. Long, J. Casey, T. Duda, S. Hodsman, S. Stricker, S. Martner, R. Hansen, F. Ferraro, R. Tangen, A. Hanratty, M. Tanabe, E. O'Callaghan, B. Houskamp, L. McDonald, L. Pick, D. Guardino, T. Pietz, K. Kayser, R. Gray, A. Letteri, A. Crisologo, G. Witkin, J. Sanders, M. Mrazik, A. Harley, M. Phoong, T. Melville, D. La, R. Gomez, L. Berthelson, J. Robbins, E. Lane, P. Rahman, L. Konopka, A. Fasfous, D. Zink, N. Peralta-Ramirez, M. Perez-Garcia, S. Su, G. Lin, T. Kiely, A. Schatzberg, J. Keller, J. Dykstra, M. Feigon, L. Renteria, M. Fong, L. Piper, E. Lee, J. Vordenberg, C. Contardo, S. Magnuson, N. Doninger, L. Luton, D. Drane, A. Phelan, W. Stricker, A. Poreh, F. Wolkenberg, J. Spira, J. DeRight, R. Jorgensen, L. Fitzpatrick, S. Crowe, S. Woods, K. Doyle, E. Weber, M. Cameron, J. Cattie, C. Cushman, I. Grant, K. Blackstone, D. Moore, B. Roberg, M. Somogie, J. Thelen, C. Lovelace, J. Bruce, A. Gerstenecker, B. Mast, I. Litvan, D. Hargrave, R. Schroeder, W. Buddin, L. Baade, R. Heinrichs, J. Boseck, K. Berry, E. Koehn, A. Davis, B. Meyer, B. Gelder, Z. Sussman, P. Espe-Pfeifer, M. Musso, A. Barker, G. Jones, W. Gouvier, V. Johnson, L. Zaytsev, M. Freier-Randall, G. Sutton, E. Ringdahl, J. Olsen, D. Byrd, M. Rivera-Mindt, R. Fellows, S. Morgello, V. Wheaton, S. Jaehnert, C. Ellis, H. Olavarria, J. Loftis, M. Huckans, P. Pimental, J. Frawley, M. Welch, K. Jennette, E. Rinehardt, M. Schoenberg, L. Strober, H. Genova, G. Wylie, J. DeLuca, N. Chiaravalloti, E. Ibrahim, A. Seiam, S. Bohlega, H. Lloyd, M. Goldberg, J. Marceaux, R. Fallows, K. McCoy, N. Yehyawi, E. Luther, R. Hilsabeck, R. Fulton, P. Stevens, S. Erickson, P. Dodzik, R. Williams, J. Dsurney, L. Najafizadeh, J. McGovern, F. Chowdhry, A. Acevedo, A. Bakhtiar, N. Karamzadeh, F. Amyot, A. Gandjbakhche, M. Haddad, M. Johnson, J. Wade, L. Harper, A. Barghi, V. Mark, G. Christopher, D. Marcus, M. Spady, J. Bloom, A. Zimmer, M. Miller, D. Schuster, H. Ebner, B. Mortimer, G. Palmer, M. Happe, J. Paxson, B. Jurek, J. Graca, J. Meyers, R. Lange, T. Brickell, L. French, G. Iverson, J. Shewchuk, B. Madler, M. Heran, J. Brubacher, B. Ivins, M. Baldassarre, T. Paper, A. Herrold, A. Chin, D. Zgaljardic, K. Oden, M. Lambert, S. Dickson, R. Miller, P. Plenger, E. Sutherland, C. Glatts, P. Schatz, K. Walker, N. Philip, S. McClaughlin, S. Mooney, E. Seats, V. Carnell, J. Raintree, D. Brown, C. Hodges, E. Amerson, C. Kennedy, J. Moore, C. Ferris, T. Roebuck-Spencer, A. Vincent, C. Bryan, D. Catalano, A. Warren, K. Monden, S. Driver, P. Chau, R. Seegmiller, M. Baker, S. Malach, J. Mintz, R. Villarreal, A. Peterson, S. Leininger, C. Strong, J. Donders, V. Merritt, G. Vargas, A. Rabinowitz, P. Arnett, E. Whipple, M. Schultheis, K. Robinson, D. Iacovone, R. Biester, D. Alfano, M. Nicholls, P. Klas, E. Jeffay, K. Zakzanis, M. Vandermeer, M. Womble, E. Corley, C. Considine, N. Fichtenberg, J. Harrison, M. Pollock, A. Mouanoutoua, A. Brimager, P. Lebby, K. Sullivan, S. Edmed, K. Kieffer, M. McCarthy, L. Wiegand, H. Lindsey, M. Hernandez, Y. Noniyeva, Y. Lapis, M. Padua, J. Poole, B. Brooks, C. McKay, W. Meeuwisse, C. Emery, A. Mazur-Mosiewicz, E. Sherman, M. Kirkwood, J. Gunner, A. Miele, G. Silk-Eglit, J. Lynch, R. McCaffrey, J. Stewart, J. Tsou, D. Scarisbrick, R. Chan, A. Bure-Reyes, L. Cortes, S. Gindy, C. Biddle, D. Shah, P. Jaberg, R. Moss, M. Horner, K. VanKirk, C. Dismuke, T. Turner, W. Muzzy, M. Dunnam, G. Warner, K. Donnelly, J. Donnelly, J. Kittleson, C. Bradshaw, M. Alt, S. Margolis, E. Ostroy, K. Higgins, K. Eng, S. Akeson, J. Wall, J. Davis, J. Hansel, B. Wang, R. Gervais, M. Greiffenstein, J. Denning, E. VonDran, E. Campbell, C. Brockman, G. Teichner, R. Waid, B. Buican, P. Armistead-Jehle, J. Bailie, A. Dilay, M. Cottingham, C. Boyd, S. Asmussen, J. Neff, S. Schalk, L. Jensen, J. DenBoer, S. Hall, E. Holcomb, B. Axelrod, G. Demakis, C. Rimland, J. Ward, M. Ross, M. Bailey, A. Stubblefield, J. Smigielski, J. Geske, V. Karpyak, C. Reese, G. Larrabee, L. Allen, M. Celinski, J. Gilman, C. LaDuke, D. DeMatteo, K. Heilbrun, T. Swirsky-Sacchetti, A. Dedman, K. Withers, T. Deneen, J. Fisher, B. Spray, R. Savage, H. Wiener, J. Tyer, V. Ningaonkar, B. Devlin, R. Go, V. Sharma, R. Fontanetta, C. Calderon, S. Coad, R. Fontaneta, M. Vertinski, R. Verbiest, J. Snyder, J. Kinney, A. Rach, J. Young, E. Crouse, D. Schretlen, J. Weaver, A. Buchholz, B. Gordon, S. Macciocchi, R. Seel, R. Godsall, J. Brotsky, A. DiRocco, E. Houghton-Faryna, E. Bolinger, C. Hollenbeck, J. Hart, B. Lee, G. Strauss, J. Adams, D. Martins, L. Catalano, J. Waltz, J. Gold, G. Haas, L. Brown, J. Luther, G. Goldstein, E. Kelley, C. Raba, L. Trettin, H. Solvason, R. Buchanan, D. Baldock, J. Etherton, T. Phelps, S. Richmond, B. Tapscott, S. Thomlinson, L. Cordeiro, G. Wilkening, M. Parikh, L. Graham, M. Grosch, L. Hynan, M. Weiner, C. Cullum, C. Menon, L. Lacritz, M. Castro-Couch, F. Irani, A. Houshyarnejad, M. Norman, F. Fonseca, B. Browne, J. Alvarez, Y. Jiminez, V. Baez, C. Resendiz, B. Scott, G. Farias, M. York, V. Lozano, M. Mahoney, M. Hernandez Mejia, E. Pacheco, A. Homs, R. Ownby, J. Nici, J. Hom, J. Lutz, R. Dean, H. Finch, S. Pierce, J. Moses, S. Mann, J. Feinberg, A. Choi, M. Kaminetskaya, C. Pierce, M. Zacharewicz, B. Gavett, J. Horwitz, J. Ory, K. Carbuccia, L. Morra, S. Garcon, M. Lucas, P. Donovick, K. Whearty, K. Campbell, S. Camlic, D. Brinckman, L. Ehrhart, V. Weisser, J. Medaglia, A. Merzagora, G. Reckess, T. Ho, S. Testa, H. Woolery, C. Farcello, N. Klimas, J. Meyer, F. Barwick, K. Drayer, J. Galusha, A. Schmitt, R. Livingston, R. Stewart, L. Quarles, M. Pagitt, C. Barke, A. Baker, N. Baker, N. Cook, D. Ahern, S. Correia, L. Resnik, K. Barnabe, D. Gnepp, M. Benjamin, Z. Zlatar, A. Garcia, S. Harnish, B. Crosson, L. Vaughan, A. Fedio, J. Sexton, S. Cummings, A. Logemann, N. Lassiter, P. Fedio, A. Gremillion, D. Nemeth, T. Whittington, J. Reckow, C. Lewandowski, J. Cole, A. Lewandowski, J. Spector, L. Ford-Johnson, J. Lengenfelder, J. Sumowski, C. Morse, J. McKeever, L. Zhao, T. Leist, J. Marcinak, K. Piecora, K. Al-Khalil, P. Martin, L. Thompson, W. Kowalczyk, S. Golub, E. Lemann, J. Piehl, N. Rita, L. Moss, R. Nogin, C. Drapeau, S. Malm, L. Armstrong, R. Glidewell, W. Orr, G. Mears, C. Allen, E. Pierson, B. Kavanaugh, F. Tayim, S. Llanes, K. Poston, J. Beathard, P. Stolberg, W. Jones, J. Mayfield, J. Weller, P. Demireva, K. McInerney, T. Riddle, M. Primus, J. Highsmith, D. Everhart, K. Lehockey, S. Sullivan, S. Mandava, B. Murphy, L. Lalwani, M. Rosselli, R. Carrasco, S. Zuckerman, J. Brand, M. Rivera Mindt, S. Schaffer, K. Alper, O. Devinsky, W. Barr, K. Langer, J. Fraiman, J. Scagliola, E. Roman, A. Martinez, K. Konopacki, A. Juliano, D. Whiteside, G. Widmann, M. Franzwa, B. Sokal, E. Morgan, M. Bondi, L. Delano-Wood, R. Cormier, N. Cumley, M. Elek, M. Green, A. Kruger, L. Pacheco, G. Robinson, H. Welch, D. Parriott, S. Loe, L. Hughes, L. Natta, W. Quenicka, K. McGoldirck, T. Bennett, H. Soper, S. Collier, M. Connolly, M. Di Pinto, E. Handel, K. Davidson, E. Livers, S. Frantz, J. Allen, T. Jerard, S. Sakhai, S. Barney, K. McGoldrick, J. Sordahl, N. Torrence, and S. John

Subjects
Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, General Medicine
Published
2012
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3. Agile software development: the business of innovation

Author

J. Highsmith and Alistair Cockburn

Subjects
Collaborative software, Knowledge management, Process management, General Computer Science, Computer science, business.industry, Change management, Extreme programming, Scrum, Documentation, New business development, Workforce, Lean software development, Digital economy, business, Agile software development
Abstract

The rise and fall of the dotcom-driven Internet economy shouldn't distract us from seeing that the business environment continues to change at a dramatically increasing pace. To thrive in this turbulent environment, we must confront the business need for relentless innovation and forge the future workforce culture. Agile software development approaches, such as extreme programming, Crystal methods, lean development, Scrum, adaptive software development (ASD) and others, view change from a perspective that mirrors today's turbulent business and technology environment.

Published
2001
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4. Agile software development, the people factor

Author

Alistair Cockburn and J. Highsmith

Subjects
Software documentation, Requirement, Agile usability engineering, General Computer Science, business.industry, Computer science, Software as a service, Empirical process (process control model), Software development, Agile Unified Process, computer.software_genre, Software development process, Extreme programming practices, Best coding practices, Release management, Systems development life cycle, Personal software process, Lean software development, business, Software engineering, P-Modeling Framework, computer, Requirements analysis, Software project management, Agile software development
Abstract

In a previous article (2001), we introduced agile software development through the problem it addresses and the way in which it addresses the problem. Here, we describe the effects of working in an agile style.

Published
2001
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8. A Clinical Method to Determine Variable Cadence Using Common Outcome Measures.

Author

T. D., Klenow and M. J., Highsmith

Subjects
*CONFERENCES & conventions, *DIAGNOSIS, *GAIT in humans, *HEALTH outcome assessment, *PSYCHOMETRICS
Abstract

INTRODUCTION The gait characteristic of cadence is commonly presented as step number per unit of time, typically per one minute, and has been found to be applicable to many conditions and interventions (Arch et al., 2017). This measure has been used in a variety of populations including those utilizing orthotic and prosthetic interventions. Cadence has increased value to individuals with LEA as measured ability to vary cadence is currently a necessary criteria for access to advanced prosthetic technology in the United States and has been considered for adoption in other developed countries including Canada, Australia, and Japan. While cadence is regularly measured with 3D kinematic systems as reported in the literature, lack of validated and reliable methods of its determination using observational gait analysis methods and calculation have prevented widespread clinical translation (Handa et al., 2007). The 10-Meter Walk Test (10MWT) and Four Square Step Test (FSST) are commonly used clinical outcome measures with strong psychometric properties. The purpose of this study is to develop a methodology for calculating cadence in from these tests in real time and to determine feasibility using convenient samples of healthy subjects from multiple sites. METHOD This multi-site study protocol was approved by the Institutional Review Board of Loma Linda University (LLU), Loma Linda, CA. Convenient samples of 20 subjects were recruited from the student bodies of LLU and Eastern Michigan University, Ypsilanti, MI, each for a total sample of 40 (n = 40). Each subject was tested in two sessions on the same day in consecutive weeks while being recorded on video and timed by two live raters. Tests were both completed at comfortable and fastest possible speeds. A discrete step timing method was used to determine cadence from each test with live times compared to video. Concurrent validity and inter-rater, intra-rater, and test-retest reliability were determined primarily using ICCs calculated with the Pearson product-moment method and determined secondarily using an analysis of variance. ICCs were also calculated between tests. RESULTS Psychometric properties ranged from adequate to excellent. Direct error of 3.97% and 9.73% for cadence calculation was measured for the 10MWT and FSST, respectively. Percent differences of 43.1% and 33.0% were found for cadence between comfortable and fastest conditions, correspondingly. DISCUSSION The results of this study developed the method of discrete step timing for determining cadence in real-time from the 10MWT and FSST at comfortable and fastest possible walking speeds. The method was found to be feasible when utilizing healthy subjects tested at two university sites in the United States. Healthy subjects have been previously used in cadence validation studies. Since the percent difference between the comfortable and fastest possible conditions for both tests exceeded the direct error, these subjects can be said to have variable cadence. Further, the ICCs between the tests at both speed conditions are less than the ICC between the FSST and FSST-FP, which previously demonstrated the ability to determine variable cadence. This shows, at least preliminarily, that variable cadence can be determined between different tests as well as within the same test. CONCLUSION A method of discrete step timing was used to calculate cadence of patients is real-time while completing the 10MWT and FSST at comfortable and fastest possible speed conditions. Further analysis determined variable cadence can be determined in this matter not only within each test, but between tests using differing constructs. [ABSTRACT FROM AUTHOR]

Published
2019

12. DuraSeal Exact Is a Safe Adjunctive Treatment for Durotomy in Spine: Postapproval Study.

Author

Kim KD, Ramanathan D, Highsmith J, Lavelle W, Gerszten P, Vale F, and Wright N

Abstract

Study Design: A nonrandomized, two-armed prospective study., Objective: Water-tight dural closure is paramount to the prevention of cerebrospinal fluid (CSF) leakage and associated complications. Synthetic polyethylene glycol (PEG) hydrogel has been used as an adjunct to sutured dural repair; however, its expansion postoperatively is a concern for neurological complications. A low-swell formulation of PEG sealant was introduced as DuraSeal Exact Spine Sealant System (DESS). A Post-Approval Study was performed primarily to evaluate the safety and efficacy of DESS for spinal dural repair compared to current alternatives, in a large patient population, reflecting a real-world practice., Methods: A total of 36 sites in the United States enrolled 429 patients treated with DESS as an adjunct to dural repair in the spinal sealant group and 406 patients treated with all other modalities in the control arm, from October 2011 to June 2016. The primary endpoint was the incidence of CSF leak within 90 days of operation. The secondary endpoints evaluated were deep surgical site infection and neurological serious adverse events., Results: The CSF leakage in the DESS group (6.6%) was not significantly different from the control group (6.5%) ( p = .83), and there was no significant difference in the time to first leak. The two groups had no significant differences in deep surgical site infection (1.6% versus control 2.1%, p = .61) or proportion of subjects with neurological serious adverse events (2.9% versus control 1.6%, p = .516)., Conclusions: DuraSeal Exact Spinal Sealant is safe when compared to current alternatives for spinal dural repair., Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The device is approved by the Food and Drug Administration. Although the authors have not received or will receive benefits for person or professional use from a commercial party related directly or indirectly to the subject of this manuscript, benefits have been or will be received but are directed solely to a research fund, foundation, educational institution, or other nonprofit organization with which the authors have been associated. The study and the preparation of the manuscript was supported by a commercial party related to the subject of the manuscript.

Published
2019
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