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We present the discovery of highly-collimated radio jets spanning a total of 355 kpc around the nearby elliptical galaxy NGC 2663, and the possible first detection of recollimation on kiloparsec scales. The small distance to the galaxy (~28.5 Mpc) allows us to resolve portions of the jets to examine their structure. We combine multiwavelength data: radio observations by the Murchison Widefield Array (MWA), the Australian Square Kilometre Array Pathfinder (ASKAP) and the Australia Telescope Compact Array (ATCA), and X-ray data from Chandra, Swift and SRG/eROSITA. We present intensity, rotation measure, polarisation, spectral index and X-ray environment maps. Regions of the southern jet show simultaneous narrowing and brightening, which can be interpreted as a signature of the recollimation of the jet by external, environmental pressure, though it is also consistent with an intermittent Active Galactic Nuclei (AGN) or complex internal jet structure. X-ray data suggest that the environment is extremely poor; if the jet is indeed recollimating, the large recollimation scale (40 kpc) is consistent with a slow jet in a low-density environment., 16 pages, 14 figures, Accepted for publication in MNRAS

Funding Acknowledgements Type of funding sources: None. Background Atrial fibrillation (AF) and chronic kidney disease (CKD) often coexist and share an increased risk of thromboembolic events. CKD concomitantly contributes to several pathophysiological changes predisposing towards a pro-haemorrhagic state. Purpose To evaluate the impact of kidney function on peri-procedural complications and clinical outcomes in AF patients undergoing left atrial appendage occlusion (LAAO) with a Watchman device. Methods 2124 consecutive AF patients undergoing Watchman implantation at 8 different centers were categorized into CKD stage 1+2 (n=1089), CKD stage 3 (n=796), CKD stage 4 (n=170), CKD stage 5 (n=69) based on the estimated glomerular filtration rate at baseline. The primary efficacy endpoint included a composite of cardiovascular (CV) mortality, stroke, transient ischemic attack, peripheral thromboembolism (TE), and major bleeding. Results A non-significant higher incidence of major peri-procedural adverse events (1.7% vs. 2.3% vs. 4.1% vs. 4.3%) was observed with worsening baseline kidney function (p=0.14). The mean follow-up period was 13 ± 7 months [2226 patient-years (PY)]. In comparison to CKD stage 1+2 as a reference, the incidence of the primary endpoint was significantly higher in CKD stage 3 (log-rank p-value= 0.04), CKD stage 4 (log-rank p-value= 0.01), and CKD stage 5 (log-rank p-value= 0.001) (Fig.1A). A non-significant increase in event rates for stroke/TIA and clinically relevant bleeding was observed among the four groups. LAAO led to a TE risk reduction of 72%, 66%, 62%, and 41% in each group (Fig.1B). The relative risk reduction in the incidence of major bleeding was 58%, 44%, 51%, and 52%, respectively (Fig.1C). Conclusion Patients with moderate-to-severe CKD had a higher incidence of the primary composite endpoint. However, the relative risk reduction in the incidence of TE and major bleeding was consistent across CKD groups, irrespective of the very different risk profiles at baseline.

Funding Acknowledgements Type of funding sources: None. Background Acute kidney injury (AKI) is a serious complication after invasive cardiac procedures and has been associated with a higher incidence of periprocedural complications and increased mortality. Data on the occurrence of AKI associated with left atrial appendage occlusion (LAAO) are very limited. Purpose To report the incidence, predictors, and clinical implications of AKI following percutaneous LAAO. Methods This multicenter registry included 2124 patients with successful Watchman implantation. AKI was defined according to the AKI Network criteria as an increase in serum creatinine of ≥0.3 mg/dL or of ≥50% over the course of 48 hours post-procedure. Patients meeting this definition were further categorized in three stages: stage 1, increase in serum creatinine ≥ 0.3 mg/dl (≥ 26.4 μmol/l) or of 1.5 to 2 times compared to baseline; stage 2, increase in serum creatinine of 2 to 3 times compared to baseline; stage 3, increase in serum creatinine of > 3 times compared to baseline or serum creatinine ≥ 4.0 mg/dl [≥ 354 μmol/l] with an acute increase of at least 0.5 mg/dl [44 μmol/l]. Results Post-procedural AKI was documented in 68 (5.5%) of 1234 patients with creatinine determination between 24 and 48 hours post-LAAO. Among them, 63 (92.6%) patients had AKI stage 1, 4 (5.9%) had AKI stage 2, and 1 (1.5%) had AKI stage 3. AKI was associated with higher CHA2DS2-VASc (5.3 ± 1.4 vs. 4.8 ± 1.4; p=0.001) and HAS-BLED (3.8 ± 0.9 vs. 3.5 ± 1.0; p=0.01) scores at baseline, as well as a higher prevalence of diabetes mellitus (p=0.04) and CHF (p At multivariate analysis (Table 1), independent predictors of AKI were CKD stage 4/5 (OR: 1.998; 95% CI: 1.018 – 3.923; p=0.04), and CHF (OR: 2.286; 95% CI: 1.328 – 3.934; p=0.01). The average follow-up was 13 ± 7 months. The annualized rates of cardiovascular mortality were 5.5% in AKI and 1.0% in non-AKI patients (p=0.01). The annualized rates of overall mortality were 15.1% in AKI and 3.4% in non-AKI patients (p Conclusion AKI was an infrequent complication following percutaneous LAAO and a powerful predictor of cardiovascular and overall mortality during follow-up.

Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): National Institute of Health Research St George's, University of London Background SCN5A-E1784K (c.5350G>A) is the most common variant associated with the LQT3 long QT syndrome (LQTS) and Brugada syndrome (BrS). It exhibits incomplete penetrance and can manifest variably as a mixed clinical phenotype of LQTS, BrS and/or conduction disorders (1-4). This presents a challenge for risk stratification and optimal management. We aimed to describe the clinical characteristics and risk markers in a large, well characterised international cohort of SCN5A-E1784K subjects and identify demographic and/or ECG parameters associated with event free survival. Methods Comprehensive clinical data, including initial presentation and follow-up data, were collected from SCN5A-E1784K subjects. Outcome ‘events’ included sudden death, aborted cardiac arrest, and documented VF or VT or arrhythmic syncope. ‘Lethal events’ included sudden death, aborted cardiac arrest or documented VF or VT. Associations between clinical characteristics and event free survival were investigated using Cox proportional hazard regression models. Results SCN5A-E1784K subjects (n=231) were recruited from 16 centres. Median follow up was 24.9 years (15.2 - 43.3) and 45 individuals (19%) experienced an event. Lethal events were observed in 14 subjects (6%). Figure 1 shows event (A) and lethal event (B) free survival in SCN5A-E1784K subjects. Higher QRS duration (corrected for age) was associated with shorter event-free interval. QRS duration was the only characteristic associated with increased risk with a hazard ratio (HR) of 1.04 or 1.05 per ms for events and lethal events, respectively. The observed survival for events and lethal events for QRS tertiles are shown in Figure 2. Discussion Ventricular myocardial conduction, as evidenced by QRS duration, appears to play a role in the risk of arrhythmic events in patients with SCN5A-E1784K. Corrected QT interval and BrS phenotype were, however, not associated with risk. This provides an important opportunity for the personalisation of risk stratification of these patients, whose management can otherwise be very challenging. Figures

Bimodal cochlear implant (CI) listeners have difficulty utilizing spatial cues to segregate competing speech, possibly due to tonotopic mismatch between the acoustic input frequency and electrode place of stimulation. The present study investigated the effects of tonotopic mismatch in the context of residual acoustic hearing in the non-CI ear or residual hearing in both ears. Speech recognition thresholds (SRTs) were measured with two co-located or spatially separated speech maskers in normal-hearing adults listening to acoustic simulations of CIs; low frequency acoustic information was available in the non-CI ear (bimodal listening) or in both ears. Bimodal SRTs were significantly better with tonotopically matched than mismatched electric hearing for both co-located and spatially separated speech maskers. When there was no tonotopic mismatch, residual acoustic hearing in both ears provided a significant benefit when maskers were spatially separated, but not when co-located. The simulation data suggest that hearing preservation in the implanted ear for bimodal CI listeners may significantly benefit utilization of spatial cues to segregate competing speech, especially when the residual acoustic hearing is comparable across two ears. Also, the benefits of bilateral residual acoustic hearing may be best ascertained for spatially separated maskers.

International audience; Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear. The aim of this study was to assess the safety of sonoporation of the round window membrane in a sheep model. To achieve this objective, we assessed auditory function and cochlear heating, and analysed the metabolomics profiles of perilymph collected after sonoporation, comparing them with those of the control ear in the same animal. Six normal-hearing ewes were studied, with one sonoporation ear and one control ear for each. A mastoidectomy was performed on both ears. On the sonoporation side, Vevo MicroMarker® microbubbles (MBs; VisualSonics—Fujifilm, Amsterdam, The Netherlands) at a concentration of 2 × 108 MB/mL were locally injected into the middle ear and exposed to 1.1 MHz sinusoidal ultrasonic waves at 0.3 MPa negative peak pressure with 40% duty cycle and 100 μs interpulse period for 1 min; this was repeated three times with 1 min between applications. The sonoporation protocol did not induce any hearing impairment or toxic overheating compared with the control condition. The metabolomic analysis did not reveal any significant metabolic difference between perilymph samples from the sonoporation and control ears. The results suggest that sonoporation of the round window membrane does not cause damage to the inner ear in a sheep model.

The auditory brainstem implant (ABI) can provide hearing sensation to individuals where the auditory nerve is damaged. However, patient outcomes with the ABI are typically much poorer than those for cochlear implant recipients. A major limitation to ABI outcomes is the number of implanted electrodes that can produce auditory responses to electric stimulation. One of the greatest challenges in ABI surgery is the intraoperative positioning of the electrode paddle, which must fit snugly within the cochlear nucleus complex. While there presently is no optimal procedure for intraoperative electrode positioning, intraoperative assessments may provide useful information regarding viable electrodes that may be included in patients’ clinical speech processors. Currently, there is limited knowledge regarding the relationship between intraoperative data and post-operative outcomes. Furthermore, the relationship between initial ABI stimulation with and long-term perceptual outcomes is unknown. In this retrospective study, we reviewed intraoperative electrophysiological data from 24 ABI patients (16 adults and 8 children) obtained with two stimulation approaches that differed in terms of neural recruitment. The interoperative electrophysiological recordings were used to estimate the number of viable electrodes and were compared to the number of activated electrodes at initial clinical fitting. Regardless of the stimulation approach, the intraoperative estimate of viable electrodes greatly overestimated the number of active electrodes in the clinical map. The number of active electrodes was associated with long-term perceptual outcomes. Among patients with 10-year follow-up, at least 11/21 active electrodes were needed to support good word detection and closed-set recognition and 14/21 electrodes to support good open-set word and sentence recognition. Perceptual outcomes were better for children than for adults, despite a lower number of active electrodes.

Introduction Hypertrophic cardiomyopathy is a complex disease of the myocardium characterised by left ventricular hypertrophy >15mm in any one segment, in the absence of loading conditions. The phenotypic variability and inhomogeneous nature of the condition have resulted in difficulties with diagnosis. Despite the significant progression in cardiac imaging and genetics, the electrocardiogram (ECG) remains the cornerstone of initial evaluation of patients with HCM and in the screening of families. Moreover, the ECG is in widespread use for pre-participation sports screening. Purpose Original and contemporary studies indicate that the ECG is normal in only 6–10% of patients with echocardiographic evidence of HCM. We hypothesised that the ECG may be normal in a significant proportion of HCM patients. This study sought to reassess the ECG as a screening tool in a HCM cohort. Methods 112 patients were selected randomly from the database of a specialist cardiomyopathy clinic. Their most recent ECG, clinical and imaging data were reviewed. All patients had echocardiographic HCM and were carriers of pathogenic sarcomere gene mutations. Patients with phenocopies were excluded. ECG data for 100 age and sex-matched controls was also analysed. ECG interpretation was performed using international criteria. Results 18% of patients with a clinical diagnosis of HCM by conventional diagnostic standards (LV wall thickness >15mm) had a normal ECG. A further 7% had a normal ECG with a mild HCM phenotype (LV wall thickness of 13–14mm). The most common abnormality observed was T wave inversion (TWI) in 28%. An additional unexpected finding in the HCM group was isolated TWI in lead aVL. This occurred in 27% of patients in the absence of any other repolarisation abnormalities, compared with 1% of controls. The significance of this finding is unclear. 27% of HCM patients displayed voltage criteria for left ventricular hypertrophy by either Cornell or Sokolow-Lyon criteria, with just 4% meeting criteria for both. 13% of HCM patients had corrected QT prolongation, in the absence of medications responsible for this. Conclusion The ECG continues to play a pivotal role in HCM diagnosis but its sensitivity to detect disease has been over-estimated. Up to a quarter of patients with HCM have a normal ECG. This is significantly higher than previously reported. The ECG in isolation therefore is not a reliable tool for screening for HCM in the general population and especially unreliable in at-risk subjects. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): The Mater Foundation

Background Hypertrophic cardiomyopathy (HCM) has long been described as the archetypal monogenic cardiac disease. It fulfils the criteria for Mendelian inheritance and painstaking early co-segregation studies by Seidman et al in 1990 lead to the discovery that mutations in MYH7 cause HCM. From here, the genetic architecture of HCM has been gradually assembled and thousands of individual mutations discovered. The complexity of HCM genetics continues to evolve to include the gene-negative cohort and those carrying multiple mutations. We sought to describe the genetic spectrum of HCM in an Irish population. Methods A retrospective examination of the proband database of a specialist cardiomyopathy clinic was undertaken to select all patients with gene-positive HCM. Their clinical data and cardiac imaging was reviewed. Mutations classified by the American College of Medical Genetics as Class 4 and 5 were considered pathogenic. Variants of uncertain significance (VUS) in candidate genes were also recorded, though not clinically actionable. Results The results of genetic testing for 254 HCM patients were reviewed. 94% of patients (n=238) had a single pathogenic HCM gene mutation. 5% of patients (n=13) had digenic disease. The remaining 1% (n=3) had oligogenic disease. MYBPC3 was the most commonly involved gene with 116 patients (45.6%) carrying a pathogenic variant. The p. Arg502Trp missense mutation is the most common mutation observed within the Irish cohort and has a founder effect in England. MYH7 mutations were found in 51 patients (20%). Troponin mutations were found in 20 patients (6.8%). Although formally classified as a VUS, there was an overrepresentation of FHOD3 mutations with 19 patients (7.4%) carrying a variant. 41 patients (16%) had pathogenic mutations in PRKAG2, LAMP2 and mitochondrial genes collectively. Discussion This Irish cohort has a similar genetic profile in sarcomeric HCM to published European registry data. There is an overrepresentation in HCM phenocopy/metabolic conditions such as mitochondrial and PRKAG2-associated cardiomyopathy. This represents a genetically homogenous small population in Ireland but also includes one of the largest Danon disease cohorts in Europe. The genetic architecture of hypertrophic cardiomyopathy is complex and the concept of monogenic sarcomeric disease is an over-simplification. There is significant phenotypic variability due to gene-gene effects and gene-dose effects, as well as elusive epigenetic modifier effects. Our understanding of the genetic complexities continues to evolve. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Mater Foundation

Hearing loss in the extended high-frequency (EHF) range (>8 kHz) is widespread among young normal-hearing adults and could have perceptual consequences such as difficulty understanding speech in noise. However, it is unclear how EHF hearing loss might affect basic psychoacoustic processes. The hypothesis that EHF hearing loss is associated with poorer auditory resolution in the standard frequencies was tested. Temporal resolution was characterized by amplitude modulation detection thresholds (AMDTs), and spectral resolution was characterized by frequency change detection thresholds (FCDTs). AMDTs and FCDTs were measured in adults with or without EHF loss but with normal clinical audiograms. AMDTs were measured with 0.5- and 4-kHz carrier frequencies; similarly, FCDTs were measured for 0.5- and 4-kHz base frequencies. AMDTs were significantly higher with the 4 kHz than the 0.5 kHz carrier, but there was no significant effect of EHF loss. There was no significant effect of EHF loss on FCDTs at 0.5 kHz; however, FCDTs were significantly higher at 4 kHz for listeners with than without EHF loss. This suggests that some aspects of auditory resolution in the standard audiometric frequency range may be compromised in listeners with EHF hearing loss despite having a normal audiogram.

For French cochlear implant (CI) recipients, in-person clinical auditory rehabilitation is typically provided during the first few years post-implantation. However, this is often inconvenient, it requires substantial time resources and can be problematic when appointments are unavailable. In response, we developed a computer-based home training software (“French AngelSound™”) for French CI recipients. We recently conducted a pilot study to evaluate the newly developed French AngelSound™ in 15 CI recipients (5 unilateral, 5 bilateral, 5 bimodal). Outcome measures included phoneme recognition in quiet and sentence recognition in noise. Unilateral CI users were tested with the CI alone. Bilateral CI users were tested with each CI ear alone to determine the poorer ear to be trained, as well as with both ears (binaural performance). Bimodal CI users were tested with the CI ear alone, and with the contralateral hearing aid (binaural performance). Participants trained at home over a one-month period (10 hours total). Phonemic contrast training was used; the level of difficulty ranged from phoneme discrimination in quiet to phoneme identification in multi-talker babble. Unilateral and bimodal CI users trained with the CI alone; bilateral CI users trained with the poorer ear alone. Outcomes were measured before training (pre-training), immediately after training was completed (post-training), and one month after training was stopped (follow-up). For all participants, post-training CI-only vowel and consonant recognition scores significantly improved after phoneme training with the CI ear alone. For bilateral and bimodal CI users, binaural vowel and consonant recognition scores also significantly improved after training with a single CI ear. Follow-up measures showed that training benefits were largely retained. These preliminary data suggest that the phonemic contrast training in French AngelSound™ may significantly benefit French CI recipients and may complement clinical auditory rehabilitation, especially when in-person visits are not possible.

In cochlear implants, loudness has been shown to grow more slowly with increasing pulse phase duration (PPD) than with pulse amplitude (PA), possibly due to “leaky” charge integration. This leakiness has been recently quantified in terms of “charge integration efficiency,” defined as the log difference between the PPD dynamic range and PA dynamic range (both expressed in charge units), relative to a common threshold anchor. Such leakiness may differ across electrodes and/or test ears, and may reflect underlying neural health. In this study, we examined the across-site variation of charge integration in recipients of Cochlear© devices. PPD and PA dynamic ranges were measured relative to two threshold anchors with either a 25- or 50-microsecond PPD. Strength-duration functions, previously shown to relate to survival of spiral ganglion cells and peripheral processes, were compared to charge integration efficiency on selected electrodes. Results showed no significant or systematic relationship between the across-site variation in charge integration efficiency and electrode position or threshold levels. Charge integration efficiency was poorer with the 50-μs threshold anchor, suggesting that greater leakiness was associated with larger PPD dynamic ranges. Poorer and more variable charge integration efficiency across electrodes was associated with longer duration of any hearing loss, consistent with the idea that poor integration is related to neural degeneration. More variable integration efficiency was also associated with poorer speech recognition performance across test ears. The slopes of the strength-duration functions at maximum acceptable loudness were significantly correlated with charge integration efficiency. However, the strength-duration slopes were not predictive of duration of any hearing loss or speech recognition performance in our participants. As such, charge integration efficiency may be a better candidate to measure leakiness in neural populations across the electrode array, as well as the general health of the auditory nerve in human cochlear implant recipients.

Background Atrial fibrillation (AF) and chronic kidney disease (CKD) often coexist and share an increased risk of thromboembolic events. CKD concomitantly contributes to several pathophysiological changes predisposing towards a pro–haemorrhagic state. Objective To evaluate the impact of kidney function on peri–procedural complications and clinical outcomes in AF patients undergoing left atrial appendage occlusion (LAAO) with a Watchman device. Methods 2124 consecutive AF patients undergoing Watchman implantation at 8 different centers were categorized into CKD stage 1 + 2 (n = 1089), CKD stage 3 (n = 796), CKD stage 4 (n = 170), CKD stage 5 (n = 69) based on the estimated glomerular filtration rate at baseline. The primary efficacy endpoint included a composite of cardiovascular (CV) mortality, stroke, transient ischemic attack, peripheral thromboembolism (TE), and major bleeding. Results A non–significant higher incidence of major peri–procedural adverse events (1.7% vs. 2.3% vs. 4.1% vs. 4.3%) was observed with worsening baseline kidney function (p = 0.14). The mean follow–up period was 13 ± 7 months [2226 patient–years (PY)]. In comparison to CKD stage 1 + 2 as a reference, the incidence of the primary endpoint was significantly higher in CKD stage 3 (log–rank p–value= 0.04), CKD stage 4 (log–rank p–value= 0.01), and CKD stage 5 (log–rank p–value= 0.001) (Fig. 1A). A non–significant increase in event rates for stroke/TIA and clinically relevant bleeding was observed among the four groups. LAAO led to a TE risk reduction of 72%, 66%, 62%, and 41% in each group (Fig. 1B). The relative risk reduction in the incidence of major bleeding was 58%, 44%, 51%, and 52%, respectively (Fig. 1C). Conclusion Patients with moderate–to–severe CKD had a higher incidence of the primary composite endpoint. The relative risk reduction in the incidence of TE and major bleeding was consistent across CKD groups, irrespective of the very different risk profiles at baseline.

Since the 2016 election, President Trump has achieved unparalleled dominance over the Republican Party. He has also given his party a central role in his reelection campaign and invested heavily in its organizational capacities. This dual approach to party leadership – domination paired with organizational investment – bears a strong resemblance to the way every Republican president since Eisenhower interacted with his party, different only in degree. Where Trump’s party leadership diverges qualitatively from past patterns is in its apparent purposes. Previous Republican presidents dominated and invested in their party for the explicit purpose of building a new majority in American politics. Reaching out to new demographic groups and trying to persuade them to join the party was integral to this project. Trump, in contrast, has (thus far) predominantly pursued a base-mobilization strategy. Rather than fan out horizontally in search of new groups to join the party coalition, Trump’s strategy drills down vertically to penetrate and deepen his base. Instead of trying to diversify the GOP and extend its reach, his strategy aims to swell the number of like-minded supporters who are active in electoral and party politics (while suppressing, demobilizing, and delegitimizing the opposition party). By setting into motion a mutually reinforcing cycle of party domination and base mobilization, and amplifying its effects through organizational investment, Trump has turned his party into a formidable vehicle for advancing his personal purposes and augmenting his power – while raising troubling questions about the stability of American democracy. This article examines Trump’s party leadership to date, compares it to previous presidential party leadership projects, and considers the implications.

The relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor threshold over a two-week period. In total, 104 right-handed patients with lateralized subjective tinnitus were randomly divided into four groups according to rTMS treatment: Left (n = 29), Right (n = 23), Bilateral (n = 30), and Sham stimulation (n = 22). Outcomes included estimates of tinnitus severity, psychological state, and psychoacoustic measures. Patients with left- or right-sided tinnitus were similarly distributed across treatment groups. There were no significant changes in outcome measures for the Right or Sham treatment groups. For the Left and Bilateral groups, tinnitus severity was significantly lower after treatment (p < 0.05). The reduction in tinnitus severity was largest for ipsilateral treatment in the Left group. The overall response rate was 56.1% for the Left group, 46.7% for the Bilateral group, 8.3% for the Right group, and 8.3% for the Sham group. For the Left and Bilateral groups, the response rate was larger for patients with left- than right-sided tinnitus. Changes in tinnitus severity were best predicted by changes in anxiety, depression, and the loudness of the tinnitus. The results suggests that rTMS on the left temporoparietal cortex is more effective for patients with left-sided than with right-sided tinnitus.

The recent detection of the quasi-stellar object (QSO) VIKING J231818.3$-$311346 (hereafter VIK J2318$-$3113) at redshift $z=6.44$ in the Rapid ASKAP Continuum Survey (RACS) uncovered its radio-loud nature, making it one of the most distant known to date in this class. By using data from several radio surveys of the Galaxy and Mass Assembly 23$^\mathrm{h}$ field and from dedicated follow-up, we were able to constrain the radio spectrum of VIK J2318$-$3113 in the observed range $\sim$0.1--10 GHz. At high frequencies (0.888--5.5 GHz in the observed frame) the QSO presents a steep spectrum ($\alpha_{\rm r}$=1.24, with $S_\nu\propto \nu^{-\alpha_{\rm r}}$), while at lower frequencies (0.4--0.888 GHz in the observed frame) it is nearly flat. The overall spectrum can be modelled by either a curved function with a rest-frame turnover around 5 GHz, or with a smoothly varying double power law that is flat below a rest-frame break frequency of about 20 GHz and which significantly steepens above it. Based on the model adopted, we estimated that the radio jets of VIK J2318$-$3113 must be a few hundred years old, in the case of a turnover, or less than few$\times$10$^4$ years, in the case of a break in the spectrum. Having multiple observations at two frequencies (888 MHz and 5.5 GHz), we further investigated the radio variability previously reported for this source. We found that the marginally significant flux density variations are consistent with the expectations from refractive interstellar scintillation, even though relativistic effects related to the orientation of the source may still play a non-negligible role. Further radio and X-ray observations are required to conclusively discern the nature of this variation., Comment: Accepted for publication in A&A

Characterising spectral variability of radio sources is a technique that offers the ability to determine the astrophysics of the intervening media, source structure, emission and absorption processes. We present broadband (0.072--10 GHz) spectral variability of 15 peaked-spectrum (PS) sources with the Australia Telescope Compact Array (ATCA) and the Murchison Widefield Array (MWA). These 15 PS sources were observed quasi-contemporaneously with ATCA and the MWA four to six times during 2020 with approximately a monthly cadence. Variability was not detected at 1--10GHz frequencies but 13 of the 15 targets show significant variability with the MWA at megahertz frequencies. We conclude the majority of variability seen at megahertz frequencies is due to refractive interstellar scintillation of a compact component ~25 mas across. We also identify four PS sources that show a change in their spectral shape at megahertz frequencies. Three of these sources are consistent with a variable optical depth from an inhomogeneous free-free absorbing cloud around the source. One PS source with a variable spectral shape at megahertz frequencies is consistent with an ejection travelling along the jet. We present spectral variability as a method for determining the physical origins of observed variability and for providing further evidence to support absorption models for PS sources where spectral modelling alone is insufficient., Comment: Accepted for publication in MNRAS. 17 pages, 10 figures

Abell 3266 is a massive and complex merging galaxy cluster that exhibits significant substructure. We present new, highly sensitive radio continuum observations of Abell 3266 performed with the Australian Square Kilometre Array Pathfinder (0.8–1.1 GHz) and the Australia Telescope Compact Array (1.1–3.1 GHz). These deep observations provide new insights into recently reported diffuse non-thermal phenomena associated with the intracluster medium, including a ‘wrong-way’ relic, a fossil plasma source, and an as-yet unclassified central diffuse ridge, which we reveal comprises the brightest part of a large-scale radio halo detected here for the first time. The ‘wrong-way’ relic is highly atypical of its kind: it exhibits many classical signatures of a shock-related radio relic, while at the same time exhibiting strong spectral steepening. While radio relics are generally consistent with a quasi-stationary shock scenario, the ‘wrong-way’ relic is not. We study the spectral properties of the fossil plasma source; it exhibits an ultrasteep and highly curved radio spectrum, indicating an extremely aged electron population. The larger scale radio halo fills much of the cluster centre, and presents a strong connection between the thermal and non-thermal components of the intracluster medium, along with evidence of substructure. Whether the central diffuse ridge is simply a brighter component of the halo, or a mini-halo, remains an open question. Finally, we study the morphological and spectral properties of the multiple complex radio galaxies in this cluster in unprecedented detail, tracing their evolutionary history., The Australia Telescope Compact Array is part of the Australia Telescope National Facility (https://ror.org/05qajvd42), which is funded by the Australian Government for operation as a National Facility managed by CSIRO. The Australian SKA Pathfinder is part of the Australia Telescope National Facility (https://ror.org/05qajvd42) that is managed by CSIRO. Operation of ASKAP is funded by the Australian Government with support from the National Collaborative Research Infrastructure Strategy. ASKAP uses the resources of the Pawsey Supercomputing Centre. Establishment of ASKAP, the Murchison Radio-astronomy Observatory and the Pawsey Supercomputing Centre are initiatives of the Australian Government, with support from the Government of Western Australia and the Science and Industry Endowment Fund. We acknowledge the Wajarri Yamatji people as the traditional owners of the Observatory site., CJR, EB, and AB acknowledge financial support from the ERC Starting Grant ‘DRANOEL’, number 714245. A. Botteon acknowledges support from the VIDI research programme with project number 639.042.729, which is financed by the Netherlands Organisation for Scientific Research (NWO). KR and MB acknowledge financial support from the ERC Starting Grant ‘MAGCOW’, no. 714196. JMD acknowledges the support of projects PGC2018-101814-B-100 and María de Maeztu, ref. MDM-2017-0765. This research was supported by the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. LDM is supported by the ERC-StG ‘ClustersXCosmo’ grant agreement 716762., This project used public archival data from the Dark Energy Survey (DES). Funding for the DES Projects has been provided by the US Department of Energy, the US National Science Foundation, the Ministry of Science and Education of Spain, the Science and Technology Facilities Council of the United Kingdom, the Higher Education Funding Council for England, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign, the Kavli Institute of Cosmological Physics at the University of Chicago, the Center for Cosmology and Astro-Particle Physics at the Ohio State University, the Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University, Financiadora de Estudos e Projetos, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico and the Ministério da Ciência, Tecnologia e Inovação, the Deutsche Forschungsgemeinschaft, and the Collaborating Institutions in the DES.

We present a set of peculiar radio sources detected using an unsupervised machine learning method. We use data from the Australian Square Kilometre Array Pathfinder (ASKAP) telescope to train a self-organizing map (SOM). The radio maps from three ASKAP surveys, Evolutionary Map of Universe pilot survey (EMU-PS), Deep Investigation of Neutral Gas Origins pilot survey (DINGO) and Survey With ASKAP of GAMA-09 + X-ray (SWAG-X), are used to search for the rarest or unknown radio morphologies. We use an extension of the SOM algorithm that implements rotation and flipping invariance on astronomical sources. The SOM is trained using the images of all "complex" radio sources in the EMU-PS which we define as all sources catalogued as "multi-component". The trained SOM is then used to estimate a similarity score for complex sources in all surveys. We select 0.5\% of the sources that are most complex according to the similarity metric, and visually examine them to find the rarest radio morphologies. Among these, we find two new odd radio circle (ORC) candidates and five other peculiar morphologies. We discuss multiwavelength properties and the optical/infrared counterparts of selected peculiar sources. In addition, we present examples of conventional radio morphologies including: diffuse emission from galaxy clusters, and resolved, bent-tailed, and FR-I and FR-II type radio galaxies. We discuss the overdense environment that may be the reason behind the circular shape of ORC candidates., Comment: Accepted in PASA, 23 pages, 16 figures

We present Hubble Space Telescope Wide Field Camera 3 photometric and grism observations of the candidate ultra-high-redshift (z>7) radio galaxy, GLEAM J0917-0012. This radio source was selected due to the curvature in its 70-230 MHz, low-frequency Murchison Widefield Array radio spectrum and its faintness in K-band. Follow-up spectroscopic observations of this source with the VLA and ALMA were inconclusive as to its redshift. Our F105W and F0986M imaging observations detect the host of GLEAM J0917-0012 and a companion galaxy, ~one arcsec away. The G102 grism observations reveal a single weak line in each of the spectra of the host and the companion. To help identify these lines we utilised several photometric redshift techniques including template fitting to the grism spectra, fitting the UV-to-radio photometry with galaxy templates plus a synchrotron model, fitting of the UV-to-near-infrared photometry with EAZY, and fitting the radio data alone with RAiSERed. For the host of GLEAM J0917-0012 we find a line at 1.12 micron and the UV-to-radio spectral energy distribution fitting favours solutions at z~2 or z~8. While this fitting shows a weak preference for the lower redshift solution, the models from the higher redshift solution are more consistent with the strength of the spectral line. The redshift constraint by RAiSERed of z>6.5 also supports the interpretation that this line could be Lyman-alpha at z=8.21; however EAZY favours the z~2 solution. We discuss the implications of both solutions. For the companion galaxy we find a line at 0.98 micron and the spectral energy distribution fitting favours solutions at z, 18 pages, 7 figures, 6 tables, accepted for publication in PASA

We describe a new low-frequency wideband radio survey of the southern sky. Observations covering 72 - 231 MHz and Declinations south of $+30^\circ$ have been performed with the Murchison Widefield Array "extended" Phase II configuration over 2018 - 2020 and will be processed to form data products including continuum and polarisation images and mosaics, multi-frequency catalogues, transient search data, and ionospheric measurements. From a pilot field described in this work, we publish an initial data release covering 1,447 sq. deg over 4h < RA < 13h, -32.7deg < Dec < -20.7deg. We process twenty frequency bands sampling 72 - 231 MHz, with a resolution of $2'$ - $45"$, and produce a wideband source-finding image across 170 - 231MHz with a root-mean-square noise of $1.27\pm0.15$ mJy/beam. Source-finding yields 78,967 components, of which 71,320 are fitted spectrally. The catalogue has a completeness of 98% at $\sim50$mJy, and a reliability of 98.2% at $5σ$ rising to 99.7% at $7σ$. A catalogue is available from Vizier; images are made available on AAO Data Central, SkyView, and the PASA Datastore. This is the first in a series of data releases from the GLEAM-X survey., 34 pages, 21 figures, 3 tables, accepted for publication in Publications of the Astronomical Society of Australia (PASA)

While unobscured and radio-quiet active galactic nuclei are regularly being found at redshifts $z > 6$, their obscured and radio-loud counterparts remain elusive. We build upon our successful pilot study, presenting a new sample of low-frequency-selected candidate high-redshift radio galaxies (HzRGs) over a sky area twenty times larger. We have refined our selection technique, in which we select sources with curved radio spectra between 72-231 MHz from the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey. In combination with the requirements that our GLEAM-selected HzRG candidates have compact radio morphologies and be undetected in near-infrared $K_{\rm s}$-band imaging from the Visible and Infrared Survey Telescope for Astronomy Kilo-degree Infrared Galaxy (VIKING) survey, we find 51 new candidate HzRGs over a sky area of approximately 1200 deg$^2$. Our sample also includes two sources from the pilot study: the second-most distant radio galaxy currently known, at $z=5.55$, with another source potentially at $z \sim 8$. We present our refined selection technique and analyse the properties of the sample. We model the broadband radio spectra between 74 MHz and 9 GHz by supplementing the GLEAM data with both publicly available data and new observations from the Australia Telescope Compact Array at 5.5 and 9 GHz. In addition, deep $K_{\rm s}$-band imaging from the High-Acuity Widefield $K$-band Imager (HAWK-I) on the Very Large Telescope and from the Southern Herschel Astrophysical Terahertz Large Area Survey Regions $K_{\rm s}$-band Survey (SHARKS) is presented for five sources. We discuss the prospects of finding very distant radio galaxies in our sample, potentially within the epoch of reionisation at $z \gtrsim 6.5$., 49 pages, 3 figures (one of which is a multi-page figure with 102 separate panels), 9 tables, accepted for publication in PASA

We report the discovery of J0624-6948, a low-surface brightness radio ring, lying between the Galactic Plane and the Large Magellanic Cloud (LMC). It was first detected at 888 MHz with the Australian Square Kilometre Array Pathfinder (ASKAP), and with a diameter of ~196 arcsec. This source has phenomenological similarities to Odd Radio Circles (ORCs). Significant differences to the known ORCs - a flatter radio spectral index, the lack of a prominent central galaxy as a possible host, and larger apparent size - suggest that J0624-6948 may be a different type of object. We argue that the most plausible explanation for J0624-6948 is an intergalactic supernova remnant due to a star that resided in the LMC outskirts that had undergone a single-degenerate type Ia supernova, and we are seeing its remnant expand into a rarefied, intergalactic environment. We also examine if a massive star or a white dwarf binary ejected from either galaxy could be the supernova progenitor. Finally, we consider several other hypotheses for the nature of the object, including the jets of an active galactic nucleus (AGN) or the remnant of a nearby stellar super-flare., Comment: 20 pages accepted to MNRAS

Listening to a target talker in the presence of other talkers follows a protracted developmental period. Such listening skills are critical for speech-language development and have clinical value. The purpose of the present study was to examine speech-in-speech recognition ability using digits in children. The major advantages of using digits are that it overcomes the biggest challenge of test administration, and digits are among the few first words children learn. Data were collected from 32 normal-hearing children (4–12 years) using full bandwidth speech materials. The test had four conditions like the Listening in Spatial Noise test. (1) Low cue: The target (male talker) and two male maskers were presented from the front. (2) Talker advantage: The target and two female maskers were presented from the front. (3) Spatial advantage: The target was presented from the front, and two male maskers were presented, one each from ±90°. (4) The target was presented from the front, and two female maskers were presented, one from ±90°. Results demonstrate developmental effects, good test-retest reliability, and feasibility of the computerized version of the test. Furthermore, results will be discussed in the context of various conditions and potential clinical applications.

Extended experience with meaningful pitch information has been shown to benefit music perception as well as speech perception where pitch cues are important, such as segregation of competing speech and tonal language perception. Interestingly, pitch perception has been shown to be similar between non-musicians who speak a tonal language and musicians who speak a non-tonal language, both of which outperform non-musicians who speak a non-tonal language. However, it is unknown whether extensive music training can further benefit pitch perception in tonal language speakers. In this study, melodic contour identification, spectro-temporal pattern perception, and masked speech recognition was measured in 16 adult normal-hearing musicians and 16 non-musicians; all were Chinese native speakers of Mandarin. Melodic contour identification, spectro-temporal pattern perception, and masked speech recognition all were significantly better for musicians than for non-musicians. Compared to non-musicians, musicians better utilized talker sex cues to segregate competing speech; utilization of talker sex cues by musicians was associated with the onset and extent of music training. Across all participants, spectro-temporal pattern perception was associated with better masked speech understanding. The data suggest that early and extensive music training may further benefit tonal language speakers’ perception and utilization of pitch cues.

Disk winds and jets are ubiquitous in active galactic nuclei (AGN), and how these two components interact remains an open question. We study the radio properties of a radio-intermediate quasar III Zw 2. We detect two jet knots J1 and J2 on parsec scales, which move at a mildly apparent superluminal speed of $1.35\,c$. Two $\gamma$-ray flares were detected in III Zw 2 in 2009--2010, corresponding to the primary radio flare in late 2009 and the secondary radio flare in early 2010. The primary 2009 flare was found to be associated with the ejection of J2. The secondary 2010 flare occurred at a distance of $\sim$0.3 parsec from the central engine, probably resulting from the collision of the jet with the accretion disk wind. The variability characteristics of III Zw 2 (periodic radio flares, unstable periodicity, multiple quasi-periodic signals and possible harmonic relations between them) can be explained by the global instabilities of the accretion disk. These instabilities originating from the outer part of the warped disk propagate inwards and can lead to modulation of the accretion rate and consequent jet ejection. At the same time, the wobbling of the outer disk may also lead to oscillations of the boundary between the disk wind and the jet tunnel, resulting in changes in the jet-wind collision site. III Zw 2 is one of the few cases observed with jet-wind interactions, and the study in this paper is of general interest for gaining insight into the dynamic processes in the nuclear regions of AGN., Comment: accepted by ApJ

Lactating sows are especially sensitive to heat stress (HS) due to high metabolic demands resulting from milk output. Therefore, there is a need to develop effective cooling technologies that reduce the impact of HS on lactating sows. The study objective was to determine whether electronically controlled cooling pads (ECP) would allow sows to remain euthermic under HS conditions. Twelve multiparous (2.69 ± 0.85) lactating sows (265.4 ± 26.1 kg) and litters (11.4 ± 0.7 piglets/litter) were assigned to either a non-functional ECP (NECP; n = 6) or an ECP (n = 6), housed in farrowing crates, and tested over two repetitions. Sows were provided feed and water ad libitum and all sows were exposed to HS (28.27 ± 1.42°C nighttime to 35.14 ± 0.70°C daytime). Body temperature (TB), was measured hourly using vaginal implants, and respiration rate (RR) was measured in 30 min intervals from 0600 to 2100 hrs over 2 d representing mid- and late lactation. Mixed model periodic regression equations were fitted to the TB and RR to time. The final model for TB included the effect of replicate, random effect of sow, day of lactation as a covariate, single-phase sine and cosine variables for each treatment and 2-phase sine and cosine periodic regression variables. The final model for RR included the random effect of sow, effect of treatment, replicate, day of lactation, sleeping, and single-phase sine and cosine functions for each treatment. An interaction (P < 0.05) between treatment and sine or cosine was observed for TB. For RR there was no interaction for treatment and cosine (P = 0.07), but an interaction (P < 0.05; -9.94) was observed for sine. The significant treatment by wavelength interactions observed indicate a change in RR and TB patterns when sows are placed on ECPs.

We observed the periodic radio transient GLEAM-X J162759.5-523504.3 (GLEAM-X J1627) using the Chandra X-ray Observatory for about 30 ks on 2022 January 22–23, simultaneously with radio observations from the Murchison Widefield Array, MeerKAT, and the Australia Telescope Compact Array. Its radio emission and 18 min periodicity led the source to be tentatively interpreted as an extreme magnetar or a peculiar highly magnetic white dwarf. The source was not detected in the 0.3–8 keV energy range with a 3σ upper limit on the count rate of 3 × 10−4 counts s−1. No radio emission was detected during our X-ray observations either. Furthermore, we studied the field around GLEAM-X J1627 using archival European Southern Observatory and DECam Plane Survey data, as well as recent Southern African Large Telescope observations. Many sources are present close to the position of GLEAM-X J1627, but only two within the 2'' radio position uncertainty. Depending on the assumed spectral distribution, the upper limits converted to an X-ray luminosity of LX < 6.5 × 1029 erg s−1 for a blackbody with temperature kT = 0.3 keV, or LX < 9 × 1029 erg s−1 for a power law with photon index Γ = 2 (assuming a 1.3 kpc distance). Furthermore, we performed magneto-thermal simulations for neutron stars considering crust- and core-dominated field configurations. Based on our multiband limits, we conclude that (i) in the magnetar scenario, the X-ray upper limits suggest that GLEAM-X J1627 should be older than ∼1 Myr, unless it has a core-dominated magnetic field or has experienced fast cooling; (ii) in the white dwarf scenario, we can rule out most binary systems, a hot sub-dwarf, and a hot magnetic isolated white dwarf (T ≳ 10.000 K), while a cold isolated white dwarf is still compatible with our limits., N.R., F.C.Z., C.D., M.R., V.G., C.P., A.B., and E.P. are supported by the ERC Consolidator Grant "MAGNESIA" under grant agreement No. 817661, and National Spanish grant No. PGC2018-095512-BI00. F.C.Z., A.B., and V.G. are also supported by Juan de la Cierva Fellowships. C.D., M.R., and C.A.'s work has been carried out within the framework of the doctoral program in Physics of the Universitat Autónoma de Barcelona. N.H.W. is supported by an Australian Research Council Future Fellowship (project number FT190100231) funded by the Australian Government. D.d.M. acknowledges financial support from the Italian Space Agency (ASI) and National Institute for Astrophysics (INAF) under agreements ASI-INAF I/037/12/0 and ASI-INAF n.2017-14-H.0 and from INAF "Sostegno alla ricerca scientifica main streams dell'INAF," Presidential Decree 43/2018 and from INAF "SKA/CTA projects," Presidential Decree 70/2016. D.B. acknowledges support from the South African National Research Foundation. D.V. is supported by the ERC Starting Grant "IMAGINE" under grant agreement No. 948582. This work was also partially supported by the program Unidad de Excelencia Maria de Maetzu de Maeztu CEX2020-001058-M and by the PHAROS COST Action (grant No. CA16214).

We present the detailed analysis of 11 local luminous infrared galaxies (LIRGs) from ultraviolet through far-infrared to radio ($\sim$70 MHz to $\sim$15 GHz) bands. We derive the astrophysical properties through spectral energy distribution (SED) modeling using the Code Investigating GALaxy Emission (CIGALE) and UltraNest codes. The radio SEDs include our new observations at 325 and 610 MHz from the GMRT and the measurements from public archives. Our main results are (1) radio SEDs show turnovers and bends, (2) the synchrotron spectral index of the fitted radio spectra ranges between $-$0.5 and $-$1.7, and (3) the infrared luminosity, dust mass, dust temperature, stellar mass, star-formation rates (SFRs) and AGN fraction obtained from CIGALE falls in the range exhibited by galaxies of the same class. The ratio of 60$\mu$m infrared and 1.4 GHz radio luminosity, the 1.4 GHz thermal fraction, and emission measure range between 2.1 and 2.9, 0.1% and 10%, 0.02 and 269.5$\times$10$^{6}$ cm$^{-6}$ pc, respectively. We conclude that the turnovers seen in the radio SEDs are due to free-free absorption; this is supported by the low AGN fraction derived from the CIGALE analysis. The decomposed 1.4 GHz thermal and nonthermal radio luminosities allowed us to compute the star formation rate (SFR) using scaling relations. A positive correlation is observed between the SFR$_{IR}$ obtained 10 Myr ago (compared to 100 Myr ago) and 1.4 GHz radio (total and nonthermal) because similar synchrotron lifetimes are expected for typical magnetic field strengths observed in these galaxies ($\approx$50$\mu$G)., Comment: ApJ accepted. Comments are welcome

Children with normal hearing (CNH) have greater difficulty segregating competing speech than do adults with normal hearing (ANH). Children with cochlear implants (CCI) have greater difficulty segregating competing speech than do CNH. In the present study, speech reception thresholds (SRTs) in competing speech were measured in Chinese Mandarin-speaking ANH, CNH, and CCIs. Target sentences were produced by a male Mandarin-speaking talker. Maskers were time-forward or -reversed sentences produced by a native Mandarin-speaking male (different from the target) or female or a non-native English-speaking male. The SRTs were lowest (best) for the ANH group, followed by the CNH and CCI groups. The masking release (MR) was comparable between the ANH and CNH group, but much poorer in the CCI group. The temporal properties differed between the native and non-native maskers and between forward and reversed speech. The temporal properties of the maskers were significantly associated with the SRTs for the CCI and CNH groups but not for the ANH group. Whereas the temporal properties of the maskers were significantly associated with the MR for all three groups, the association was stronger for the CCI and CNH groups than for the ANH group.

Spatial cues can facilitate segregation of target speech from maskers. However, in clinical practice, masked speech understanding is most often evaluated using co-located speech and maskers (i.e., without spatial cues). Many hearing aid centers in France are equipped with five-loudspeaker arrays, allowing masked speech understanding to be measured with spatial cues. It is unclear how hearing status may affect utilization of spatial cues to segregate speech and noise. In this study, speech reception thresholds (SRTs) for target speech in “diffuse noise” (target speech from 1 speaker, noise from the remaining 4 speakers) in 297 adult listeners across 9 Audilab hearing centers. Participants were categorized according to pure-tone-average (PTA) thresholds: typically-hearing (TH; ≤ 20 dB HL), mild hearing loss (Mild; >20 ≤ 40 dB HL), moderate hearing loss 1 (Mod-1; >40 ≤ 55 dB HL), and moderate hearing loss 2 (Mod-2; >55 ≤ 65 dB HL). All participants were tested without aided hearing. SRTs in diffuse noise were significantly correlated with PTA thresholds, age at testing, as well as word and phoneme recognition scores in quiet. Stepwise linear regression analysis showed that SRTs in diffuse noise were significantly predicted by a combination of PTA threshold and word recognition scores in quiet. SRTs were also measured in co-located and diffuse noise in 65 additional participants. SRTs were significantly lower in diffuse noise than in co-located noise only for the TH and Mild groups; masking release with diffuse noise (relative to co-located noise) was significant only for the TH group. The results are consistent with previous studies that found that hard of hearing listeners have greater difficulty using spatial cues to segregate competing speech. The data suggest that speech understanding in diffuse noise provides additional insight into difficulties that hard of hearing individuals experience in complex listening environments.