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3. Two-stage hepatectomy in resection of colorectal liver metastases – a single-institution experience with case-control matching and review of the literature

Author

Turk Spela, Plahuta Irena, Magdalenic Tomislav, Spanring Tajda, Laufer Kevin, Mavc Zan, Potrc Stojan, and Ivanecz Arpad

Subjects
colorectal cancer, liver metastases, hepatectomy, future liver remnant, posthepatectomy liver failure, survival analysis, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Two-stage hepatectomy (TSH) has been proposed for patients with bilateral liver tumours who have a high risk of posthepatectomy liver failure after one-stage hepatectomy (OSH). This study aimed to determine the outcomes of TSH for extensive bilateral colorectal liver metastases.

Published
2023
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4. Results from the european survey on preoperative management and optimization protocols for PeriHilar cholangiocarcinoma

Author

Sutcliffe, Robert, Olthof, Pim, Ruzzenente, Andrea, Botea, Florin, Gringeri, Enrico, Bartsch, Fabian, Russolillo, Nadia, Sposito, Carlo, Serenari, Matteo, Ardito, Francesco, Garnier, Jonathan, Fretland, Asmund, Ivanecz, Arpad, Scatton, Olivier, Lukashenko, Andrii, Ben, Santi L., Lopez Bravo, Miguel A., Siriwardena, Ajith, Schiesser, Marc, Jovine, Elio, Koerkamp, Bas G., Soubrane, Olivier, Dejong, Cornelis H., Muscari, Fabrice, Trudnikov, Andre, Sallinen, Ville, Sandstrom, Par, Barauskas, Giedrius, Pudil, Jiri, Bjornsson, Bergthor, Schwarz, Lilian, Schadde, Erik, Gruenberger, Thomas, Rotellar, Fernando, Christos, Dervenis, Treska, Vladislav, Fuks, David, Schmidt, Jan, Can, Fatih M., Aranda, Fernando P., Solecki, Michal, Ratti, Francesca, Marino, Rebecca, Muiesan, Paolo, Zieniewicz, Krzysztof, Van Gulik, Tomas, Guglielmi, Alfredo, Marques, Hugo P., Andres, Valdivieso, Schnitzbauer, Andreas, Irinel, Popescu, Schmelzle, Moritz, Sparrelid, Ernesto, Fusai, Giuseppe K., Adam, Renè, Cillo, Umberto, Lang, Hauke, Oldhafer, Karl, Ruslan, Alikhanov, Ciria, Ruben, Ferrero, Alessandro, Mazzaferro, Vincenzo, Cescon, Matteo, Giuliante, Felice, Nadalin, Silvio, Golse, Nicolas, Sulpice, Laurent, Serrablo, Alejandro, Ramos, Emilio, Marchese, Ugo, Rosok, Bard, Lopez-Lopez, Victor, Clavien, Pierre, and Aldrighetti, Luca

Published
2023
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5. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Abe, Tomoyuki, Abu Hilal, Moh'd, Achalandabaso Boira, Maria del Mar, Adham, Mustapha, Adam, Mohamed, Ahmad, Maryam, Al-Sarireh, Bilal, Albiol, Maite, Alhaboob, Nassir, Alseidi, Adnan, Ammar, Houssem, Anand, Akshay, Andersson, Bodil, Antonakis, Pantelis, Araya, Veronica, Ashley, Stanley W., Atanasov, Georgi, Ausania, Fabio, Balestri, Ricardo, Banerjee, Abhirup, Banerjee, Sudeep, Banting, Simon, Barauskas, Giedrius, Bartsch, Fabian, Belli, Andrea, Beretta, Simona, Berrevoet, Frederik, Bhandari, Ramesh Singh, Blanco Fernandez, Gerardo, Bolm, Louisa, Bonal, Mathieu, Bozkurt, Emre, Braat, Andries E., Bradshaw, Luke, Bramis, Konstantinos, Branes, Alejandro, Burdine, Lyle, Byrne, Matthew, Caceres, Maria, Castro Santiago, Maria Jesus, Chan, Benjamin, Chong, Lynn, Çoker, Ahmet, Conde Rodriguez, Maria, Croagh, Daniel, Crutchley, Alyn, Cutolo, Carmen, D'Hondt, Mathieu, D'Souza, Daniel, Daams, Freek, Dalla Valle, Raffaele, Davide, José, de Bellis, Mario, de Boer, Marieke, de Meyere, Celine, de Reuver, Philip, Dixon, Matthew, Dorovinis, Panagiotis, Echeverría Bauer, Gabriela, Eduarda, Maria, Eker, Hasan, Erdmann, Joris, Erkan, Mert, Felekouras, Evangelos, Felli, Emanuele, Fernandes, Eduardo, Figueroa Rivera, Eduardo, Fulop, Andras, Galun, Daniel, Gerhards, Michael, Ghorbani, Poya, Giannone, Fabio, Gil, Luis, Giorgakis, Emmanouil, Giuffrida, Mario, Giuliante, Felice, Gkekas, Ioannis, Gomez Bravo, Miguel, Groot Koerkamp, Bas, Guevara, Oscar, Guglielmi, Alfredo, Gulla, Aiste, Gupta, Rahul, Gupta, Amit, Gutiérrez, Marta, Hafeez Bhatti, Abu Bakar, Hagendoorn, Jeroen, Hajee, Zain, Hakeem, Abdul Rahman, Hamid, Hytham, Hassen, Sayed, Heinrich, Stefan, Higuchi, Ryota, Hoffman, Daniel, Holroyd, David, Hughes, Daniel, Ivanecz, Arpad, Iype, Satheesh, Jaen Torrejimeno, Isabel, Joglekar, Shantanu, Jones, Robert, Kaczirek, Klaus, Kanhere, Harsh, Kausar, Ambareen, Kee, Zhanyi, Keilson, Jessica, Kleef, Jorg, Klose, Johannes, Knowles, Brett, Koong, Jun Kit, Kumar, Nagappan, Kunnuru, Supreeth, Lakhey, Paleswan Joshi, Laurenzi, Andrea, Lee, Yeong Sing, Leon, Felipe, Leow, Voon Meng, Lequeu, Jean-Baptiste, Lesurtel, Mickael, Lo, Elisabeth, Löb, Stefan, Lockie, Elizabeth, Lodge, Peter, López Garnica, Dolores, Lopez Lopez, Victor, Lundgren, Linda, Machairas, Nikolaos, Maharjan, Dhiresh, Malde, Deep, Martel, Guillaume, Martin, Julie, Mazzola, Michele, Mehrabi, Arianeb, Memeo, Ricardo, Milana, Flavio, Molina, George, Monette, Leah, Morgul, Haluk, Moris, Dimitrios, Morsi-Yeroyannis, Antonios, Mowbray, Nicholas, Mulita, Francesk, Muttillo, Edoardo Maria, Nandasena, Malith, Nashidengo, Pueya Rashid, Nickkholgh, Arash, Noel, Colin Byron, Ohtsuka, Masayuki, Ozolins, Arturs, Pandanaboyana, Sanjay, Pararas, Nikolaos, Parente, Alessandro, Peng, June, Perfecto Valero, Arkaitz, Perinel, Julie, Perivoliotis, Konstatinos, Perra, Teresa, Pessaux, Patrick, Petruch, Natalie, Piccolo, Gaetano, Piros, Laszlo, Porcu, Alberto, Prabakaran, Viswakumar, Prasad, Raj, Prieto Calvo, Mikel, Primavesi, Florian, Pueyo Periz, Eva Maria, Quaglia, Alberto, Ramia Angel, Jose M., Rammohan, Ashwin, Razionale, Francesco, Robles Campos, Ricardo, Roy, Manas, Rozwadowski, Sophie, Ruffolo, Luis, Ruiz, Natalia, Ruzzenante, Andrea, Saadat, Lily, Said, Mohamed Amine, Saladino, Edoardo, Saliba, Gabriel, Sandstrom, Per, Schena, Carlo Alberto, Scholer, Anthony, Schwarz, Christoph, Serafini, Lorenzo, Serrano, Pablo E., Sharma, Deepak, Sheen, Aali, Siddagangaiah, Vishwanath, Silva, Michael, Singh, Saurabh, Siriwardena, Ajith, Skalski, Michal, Smig, Mante, Soliman, Faris, Sonkar, Abhinav Arun, Sousa Silva, Donzília, Sparrelid, Ernesto, Srinivasan, Parthi, Sternby Eilard, Malin, Strobel, Oliver, Stupan, Urban, Suarez-Munoz, Miguel Angel, Subramaniam, Manisekar, Sugiura, Teiichi, Sutcliffe, Robert, Swank, Hilko, Taylor, Lillian, Thapa, Prabin Bikram, The, Catherine, Thepbunchonchai, Asara, Thieu, Caman, Tiwari, Navneet, Torzilli, Guido, Tovikkai, Chutwichai, Trotovsek, Blaz, Tsaramanidis, Savvas, Tsoulfas, Georgios, Uesaka, Katsuhiko, Umar, Garzali, Urbani, Lucio, Vailas, Michail, van Dam, Ronald, van de Boezem, Peter, van Laarhoven, Stijn, Vanagas, Tomas, Van Dooren, Mike, Viennet, Manon, Vigano, Luca, Vijayashanker, Aarathi, Villodre, Celia, Wakai, Toshifumi, Workneh, Aklile, Xu, Li, Yamamoto, Masakazu, Yang, Zhiying, Young, Robert, Zivanovic, Marko, Balakrishnan, Anita, Barmpounakis, Petros, Demiris, Nikolaos, Jah, Asif, Spiers, Harry V.M., Talukder, Shibojit, Martin, Jack L., Gibbs, Paul, Harper, Simon J.F., Huguet, Emmanuel L., Kosmoliaptsis, Vasilis, Liau, Siong S., Praseedom, Raaj K., Basu, Bristi, de Aretxabala, Xavier, Lendoire, Javier, Maithel, Shishir, Serrablo, Alejandro, and Adsay, Volkan

Published
2023
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6. Heterogeneity of management practices surrounding operable gallbladder cancer – results of the OMEGA-S international HPB surgical survey

Author

Abe, T., Achalandabaso, M., Adham, M., Ahmet, A., Al-Sarireh, B., Albiol Quer, M., Alconchel, F., Alsammani, M., Alseidi, A., Anand, A., Anselmo, A., Antonakis, P., Arabadzhieva, E., de Aretxabala, X., Aroori, S., Ashley, S., Ausania, F., Banerjee, A., Barabino, M., Bartlett, A., Bartsch, F., Belli, A., Beristain-Hernandez, J., Berrevoet, F., Bhatti, A.B.H., Bhojwani, R., Bjornsson, B., Blaz, T., Byrne, M., Calvo, M.P., Castellanos, J., Castro, M.J., Cavallucci, D., Chang, D., Christodoulis, G., Ciacio, O., Clavien, P.A., Coker, A., Conde-Rodriguez, M., D'Amico, F.E., D'Hondt, M., Daams, F., Dasari, B.V.M., De Bellis, M., de Meijer, V.E., Dede, K., Deiro, G., Delgado, F.J.B., Desai, G., Di Gioia, A., Di Martino, M., Dixon, M., Dorovinis, P., Dumitrascu, T., Ebata, T., Eilard, M.S., Erdmann, J., Erkan, M., Famularo, S., Felli, E., Fergadi, M., Fernandez, G.B., Fox, A., Galodha, S., Galun, D., Ganandha, S., Garcia, R.J.R., Gemenetzis, G., Giannone, F., Gil, L., Giorgakis, E., Giovinazzo, F., Giuffrida, M., Giuliani, T., Giuliante, F., Gkekas, I., Goel, M., Goh, B.K., Gomes, A., Gruenberger, T., Guevara, O., Gulla, A., Gupta, A., Gupta, R., Hakeem, A.R., Hamid, H.K.S., Heinrich, S., Helton, S., Hernandez-Alejandro, R., Heumann, A., Higuchi, R., Hughes, D., Inarejos, B.C., Ivanecz, A., Iwao, Y., Iype, S., Jaen, I., Jie, M.J., Jones, R., Kacirek, K., Kalayarasan, R., Kaldarov, A., Kaman, L., Kanhere, H., Kapoor, V.K., Karanicolas, P., Karayiannakis, A., Kausar, A., Khan, Z.A., Kim, D.-S., Klose, J., Knowles, B., Koh, P.S., Kolodziejczyk, P., Komorowski, A.L., Koong, J.K., Kozyrin, I., Krishna, A., Kron, P., Kumar, N., van Laarhoven, S., Lakhey, P.J., Lanari, J., Laurenzi, A., Leow, V.M., Limbu, Y., Liu, Y.-B., Lob, S., Lolis, E., Lopez-Lopez, V., Lozano, R.C., Lundgren, L., Machairas, N., Magouliotis, D., Mahamid, A., Malde, D., Malek, A., Malik, H., Malleo, G., Marino, M.V., Mayo, S.C., Mazzola, M., Memeo, R., Menon, K., Menzulin, R., Mohan, R., Morgul, H., Moris, D., Mulita, F., Muttillo, E.M., Nahm, C., Nandasena, M., Nashidengo, P.R., Nickkholgh, A., Nikov, A., Noel, C., O'Reilly, D., O'Rourke, T., Ohtsuka, M., Omoshoro-Jones, J.A.O., Pandanaboyana, S., Pararas, N., Patel, R., Patkar, S., Peng, J.S., Perfecto, A., Perinel, J., Perivoliotis, K., Perra, T., Phan, M.T., Piccolo, G., Porcu, A., Primavesi, F., Primrose, J., Pueyo-Periz, E., Radenkovic, D., Rammohan, A., Rowcroft, A., Sakata, J., Saladino, E., Schena, C.A., Scholer, A., Schwarz, C., Serrano, P., Silva, M., Soreide, K., Sparrelid, E., Stattner, S., Sturesson, C., Sugiura, T., Sumo, M., Sutcliffe, R., Teh, C., Teo, J.Y., Tepetes, K., Thapa, P.B., Thepbunchonchai, A., Torres, J.B.P., Torres, O.J.M., Torzili, G., Tovikkai, C., Troncoso, A., Tsoulfas, G., Tuzuher, A., Tzimas, G., Umar, G.I., Urbani, L., Vanagas, T., Varga, Velayutham, V., Vigano, L., Wakai, T., Yang, Z., Yip, V., Zacharoulis, D., Zakharov, E.A., Zimmitti, G., Balakrishnan, Anita, Jah, Asif, Lesurtel, Mickael, Andersson, Bodil, Gibbs, Paul, Harper, Simon J.F., Huguet, Emmanuel L., Kosmoliaptsis, Vasilis, Liau, Siong S., Praseedom, Raaj K., Ramia, Jose M., Branes, Alejandro, Lendoire, Javier, Maithel, Shishir, and Serrablo, Alejandro

Published
2022
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7. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort studyResearch in context

Author

Anita Balakrishnan, Petros Barmpounakis, Nikolaos Demiris, Asif Jah, Harry V.M. Spiers, Shibojit Talukder, Jack L. Martin, Paul Gibbs, Simon J.F. Harper, Emmanuel L. Huguet, Vasilis Kosmoliaptsis, Siong S. Liau, Raaj K. Praseedom, Bristi Basu, Xavier de Aretxabala, Javier Lendoire, Shishir Maithel, Alejandro Branes, Bodil Andersson, Alejandro Serrablo, Volkan Adsay, Tomoyuki Abe, Moh'd Abu Hilal, Maria del Mar Achalandabaso Boira, Mustapha Adham, Mohamed Adam, Maryam Ahmad, Bilal Al-Sarireh, Maite Albiol, Nassir Alhaboob, Adnan Alseidi, Houssem Ammar, Akshay Anand, Pantelis Antonakis, Veronica Araya, Stanley W. Ashley, Georgi Atanasov, Fabio Ausania, Ricardo Balestri, Abhirup Banerjee, Simon Banting, Giedrius Barauskas, Fabian Bartsch, Andrea Belli, Simona Beretta, Frederik Berrevoet, Gerardo Blanco Fernandez, Louisa Bolm, Mathieu Bonal, Emre Bozkurt, Andries E. Braat, Luke Bradshaw, Lyle Burdine, Matthew Byrne, Maria Caceres, Maria Jesus Castro Santiago, Benjamin Chan, Lynn Chong, Ahmet Çoker, Maria Conde Rodriguez, Daniel Croagh, Alyn Crutchley, Carmen Cutolo, Mathieu D'Hondt, Daniel D'Souza, Freek Daams, Raffaele Dalla Valle, José Davide, Mario de Bellis, Marieke de Boer, Celine de Meyere, Philip de Reuver, Matthew Dixon, Panagiotis Dorovinis, Gabriela Echeverría Bauer, Maria Eduarda, Hasan Eker, Joris Erdmann, Mert Erkan, Evangelos Felekouras, Emanuele Felli, Eduardo Fernandes, Eduardo Figueroa Rivera, Andras Fulop, Daniel Galun, Michael Gerhards, Poya Ghorbani, Fabio Giannone, Luis Gil, Emmanouil Giorgakis, Mario Giuffrida, Felice Giuliante, Ioannis Gkekas, Miguel Gomez Bravo, Bas Groot Koerkamp, Oscar Guevara, Alfredo Guglielmi, Aiste Gulla, Rahul Gupta, Amit Gupta, Marta Gutiérrez, Abu Bakar Hafeez Bhatti, Jeroen Hagendoorn, Zain Hajee, Abdul Rahman Hakeem, Hytham Hamid, Sayed Hassen, Stefan Heinrich, Ryota Higuchi, Daniel Hoffman, David Holroyd, Daniel Hughes, Arpad Ivanecz, Satheesh Iype, Isabel Jaen Torrejimeno, Shantanu Joglekar, Robert Jones, Klaus Kaczirek, Harsh Kanhere, Ambareen Kausar, Zhanyi Kee, Jessica Keilson, Jorg Kleef, Johannes Klose, Brett Knowles, Jun Kit Koong, Nagappan Kumar, Supreeth Kunnuru, Paleswan Joshi Lakhey, Andrea Laurenzi, Yeong Sing Lee, Felipe Leon, Voon Meng Leow, Jean-Baptiste Lequeu, Mickael Lesurtel, Elisabeth Lo, Stefan Löb, Elizabeth Lockie, Peter Lodge, Dolores López Garnica, Victor Lopez Lopez, Linda Lundgren, Nikolaos Machairas, Dhiresh Maharjan, Deep Malde, Guillaume Martel, Julie Martin, Michele Mazzola, Arianeb Mehrabi, Ricardo Memeo, Flavio Milana, George Molina, Leah Monette, Haluk Morgul, Dimitrios Moris, Antonios Morsi-Yeroyannis, Nicholas Mowbray, Francesk Mulita, Edoardo Maria Muttillo, Malith Nandasena, Pueya Rashid Nashidengo, Arash Nickkholgh, Colin Byron Noel, Masayuki Ohtsuka, Arturs Ozolins, Sanjay Pandanaboyana, Nikolaos Pararas, Alessandro Parente, June Peng, Arkaitz Perfecto Valero, Julie Perinel, Konstatinos Perivoliotis, Teresa Perra, Patrick Pessaux, Natalie Petruch, Gaetano Piccolo, Laszlo Piros, Alberto Porcu, Viswakumar Prabakaran, Raj Prasad, Mikel Prieto Calvo, Florian Primavesi, Eva Maria Pueyo Periz, Alberto Quaglia, Jose M. Ramia Angel, Ashwin Rammohan, Francisco Razionale, Ricardo Robles Campos, Manas Roy, Sophie Rozwadowski, Luis Ruffolo, Natalia Ruiz, Andrea Ruzzenante, Lily Saadat, Mohamed Amine Said, Edoardo Saladino, Gabriel Saliba, Per Sandstrom, Carlo Alberto Schena, Anthony Scholer, Cristoph Schwartz, Lorenzo Serafini, Pablo Serrano, Deepak Sharma, Aali Sheen, Vishwanath Siddagangaiah, Michael Silva, Saurabh Singh, Ajith Siriwardena, Michal Skalski, Mante Smig, Faris Soliman, Donzília Sousa Silva, Ernesto Sparrelid, Parthi Srinivasan, Malin Sternby Eilard, Oliver Strobel, Urban Stupan, Miguel Angel Suarez-Munoz, Manisekar Subramaniam, Teiichi Sugiura, Robert Sutcliffe, Hilko Swank, Lillian Taylor, Prabin Bikram Thapa, Catherine The, Asara Thepbunchonchai, Caman Thieu, Navneet Tiwari, Guido Torzilli, Chutwichai Tovikkai, Blaz Trotovsek, Savvas Tsaramanidis, Georgios Tsoulfas, Katsuhiko Uesaka, Garzali Umar, Lucio Urbani, Michail Vailas, Ronald van Dam, Peter van de Boezem, Stijn van Laarhoven, Tomas Vanagas, Mike Van Dooren, Manon Viannet, Luca Vigano, Aarathi Vijayashanker, Celia Villodre, Toshifumi Wakai, Aklile Workneh, Li Xu, Masakazu Yamamoto, Zhiying Yang, Robert Young, and Marko Zivanovic

Subjects
Gallbladder cancer, Liver resection, Surgical outcomes, Cholangiocarcinoma, Medicine (General), R5-920
Abstract

Summary: Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study assesses factors associated with recurrence-free survival (RFS), overall survival (OS) and morbidity and mortality following GBC surgery in high income countries (HIC) and low and middle income countries (LMIC). Methods: The multicentre, retrospective Operative Management of Gallbladder Cancer (OMEGA) cohort study included all patients who underwent GBC resection across 133 centres between 1st January 2010 and 31st December 2020. Regression analyses assessed factors associated with OS, RFS and morbidity. Findings: On multivariable analysis of all 3676 patients, wedge resection and segment IVb/V resection failed to improve RFS (HR 1.04 [0.84–1.29], p = 0.711 and HR 1.18 [0.95–1.46], p = 0.13 respectively) or OS (HR 0.96 [0.79–1.17], p = 0.67 and HR 1.48 [1.16–1.88], p = 0.49 respectively), while major hepatectomy was associated with worse RFS (HR 1.33 [1.02–1.74], p = 0.037) and OS (HR 1.26 [1.03–1.53], p = 0.022). Furthermore, EBDR (OR 2.86 [2.3–3.52], p

Published
2023
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8. Ranking as a Procedure for Selecting a Replacement Variable in the Score Predicting the Survival of Patients Treated with Curative Intent for Colorectal Liver Metastases

Author

Irena Plahuta, Matej Mencinger, Iztok Peruš, Tomislav Magdalenić, Špela Turk, Aleks Brumec, Stojan Potrč, and Arpad Ivanecz

Subjects
colorectal cancer, liver metastases, inflammation, ranking, survival, Medicine (General), R5-920
Abstract

Background and Objectives: The issue of a missing variable precludes the external validation of many prognostic models. For example, the Liverpool score predicts the survival of patients undergoing surgical therapy for colorectal liver metastases, but it includes the neutrophil–lymphocyte ratio, which cannot be measured retrospectively. Materials and Methods: We aimed to find the most appropriate replacement for the neutrophil–lymphocyte ratio. Survival analysis was performed on data representing 632 liver resections for colorectal liver metastases from 2000 to 2020. Variables associated with the Liverpool score, C-reactive protein, albumins, and fibrinogen were ranked. The rankings were performed in four ways: The first two were based on the Kaplan-Meier method (log-rank statistics and the definite integral IS between two survival curves). The next method of ranking was based on univariate and multivariate Cox regression analyses. Results: The ranks were as follows: the radicality of liver resection (rank 1), lymph node infiltration of primary colorectal cancer (rank 2), elevated C-reactive protein (rank 3), the American Society of Anesthesiologists Classification grade (rank 4), the right-sidedness of primary colorectal cancer (rank 5), the multiplicity of colorectal liver metastases (rank 6), the size of colorectal liver metastases (rank 7), albumins (rank 8), and fibrinogen (rank 9). Conclusions: The ranking methodologies resulted in almost the same ranking order of the variables. Elevated C-reactive protein was ranked highly and can be considered a relevant replacement for the neutrophil–lymphocyte ratio in the Liverpool score. These methods are suitable for ranking variables in similar models for medical research.

Published
2023
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9. The learning curve of laparoscopic liver resection utilising a difficulty score

Author

Ivanecz Arpad, Plahuta Irena, Mencinger Matej, Perus Iztok, Magdalenic Tomislav, Turk Spela, and Potrc Stojan

Subjects
learning curve, difficulty score, laparoscopy, hepatectomy, intraoperative complication, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

This study aimed to quantitatively evaluate the learning curve of laparoscopic liver resection (LLR) of a single surgeon.

Published
2021
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10. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author

MS CGO, Cancer, van Ramshorst, Tess M.E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Saati, Hani Al, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D’Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Alvarez, Francisco Espin, Esposito, Alessandro, Ferrari, Giovanni, Koerkamp, Bas Groot, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D.P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I., Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Benedetto, Fabrizio Di, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., Hilal, Mohammad Abu, MS CGO, Cancer, van Ramshorst, Tess M.E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Saati, Hani Al, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D’Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Alvarez, Francisco Espin, Esposito, Alessandro, Ferrari, Giovanni, Koerkamp, Bas Groot, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D.P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I., Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Benedetto, Fabrizio Di, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., and Hilal, Mohammad Abu

Published
2024

11. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS)

Author

Abu Hilal, Mohammad, Van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D'Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, Van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, De Graaf, Nine, Van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., Asbun, Horacio J., Abu Hilal, Mohammad, Van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D'Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, Van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, De Graaf, Nine, Van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., and Asbun, Horacio J.

Abstract

Objective: To develop and update evidence-based and consensus-based guidelines on laparoscopic and robotic pancreatic surgery. Summary Background Data: Minimally invasive pancreatic surgery (MIPS), including laparoscopic and robotic surgery, is complex and technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines. Since the International Miami Guidelines on MIPS in 2019, new developments and key publications have been reported, necessitating an update. Methods: Evidence-based guidelines on 22 topics in 8 domains were proposed: terminology, indications, patients, procedures, surgical techniques and instrumentation, assessment tools, implementation and training, and artificial intelligence. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS, September 2022) used the Scottish Intercollegiate Guidelines Network (SIGN) methodology to assess the evidence and develop guideline recommendations, the Delphi method to establish consensus on the recommendations among the Expert Committee, and the AGREE II-GRS tool for guideline quality assessment and external validation by a Validation Committee. Results: Overall, 27 European experts, 6 international experts, 22 international Validation Committee members, 11 Jury Committee members, 18 Research Committee members, and 121 registered attendees of the 2-day meeting were involved in the development and validation of the guidelines. In total, 98 recommendations were developed, including 33 on laparoscopic, 34 on robotic, and 31 on general MIPS, covering 22 topics in 8 domains. Out of 98 recommendations, 97 reached at least 80% consensus among the experts and congress attendees, and all recommendations were externally validated by the Validation Committee. Conclusions: The EGUMIPS evidence-based guidelines on laparoscopic and robotic MIPS can be applied in current clinical practice to provide guidance to patients, surgeons, policy-m

Published
2024

12. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author

van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., Abu Hilal, Mohammad, van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., and Abu Hilal, Mohammad

Abstract

Funding Agencies|Intuitive grant for the LEARNBOT European Robotic Pancreatoduodenectomy training programme; DIPLOMA-2 trial; E-MIPS Registry; Medtronic grant for the investigator-initiated DIPLOMA trial; Ethicon grant for the PANDORINA trial; Intuitive for robotic pancreatoduodenectomy training

Published
2024
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15. The external validation of a difficulty scoring system for predicting the risk of intraoperative complications during laparoscopic liver resection

Author

Arpad Ivanecz, Irena Plahuta, Tomislav Magdalenić, Matej Mencinger, Iztok Peruš, Stojan Potrč, and Bojan Krebs

Subjects
Artificial neural network, Liver resection, Laparoscopy, Predictive score, Intraoperative complication, Cumulative distribution function, Surgery, RD1-811
Abstract

Abstract Background This study aimed to externally validate and upgrade the recent difficulty scoring system (DSS) proposed by Halls et al. to predict intraoperative complications (IOC) during laparoscopic liver resection (LLR). Methods The DSS was validated in a cohort of 128 consecutive patients undergoing pure LLRs between 2008 and 2019 at a single tertiary referral center. The validated DSS includes four difficulty levels based on five risk factors (neoadjuvant chemotherapy, previous open liver resection, lesion type, lesion size and classification of resection). As established by the validated DSS, IOC was defined as excessive blood loss (> 775 mL), conversion to an open approach and unintentional damage to surrounding structures. Additionally, intra- and postoperative outcomes were compared according to the difficulty levels with usual statistic methods. The same five risk factors were used for validation done by linear and advanced nonlinear (artificial neural network) models. The study was supported by mathematical computations to obtain a mean risk curve predicting the probability of IOC for every difficulty score. Results The difficulty level of LLR was rated as low, moderate, high and extremely high in 36 (28.1%), 63 (49.2%), 27 (21.1%) and 2 (1.6%) patients, respectively. IOC was present in 23 (17.9%) patients. Blood loss of >775 mL occurred in 8 (6.2%) patients. Conversion to open approach was required in 18 (14.0%) patients. No patients suffered from unintentional damage to surrounding structures. Rates of IOC (0, 9.5, 55.5 and 100%) increased gradually with statistically significant value among difficulty levels (P

Published
2019
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16. Factors affecting the morbidity and mortality of diverting stoma closure: retrospective cohort analysis of twelve-year period

Author

Krebs Bojan, Ivanecz Arpad, Potrc Stojan, and Horvat Matjaz

Subjects
low anterior resection, surgical stoma closure, risk factors, morbidity, mortality, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Diverting stoma is often performed in rectal cancer surgery for reducing the consequences of possible anastomotic failure. Closing of stoma follows in most cases after a few months. The aim of our study was to evaluate morbidity and mortality after diverting stoma closure and to identify risk factors for complications of this procedure.

Published
2019
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17. Abandonment of surveillance, followed by emergency surgery for a second spontaneous rupture of hepatocellular carcinoma: A case report and review of the literature

Author

Irena Plahuta, Mihael Jelenko, Stojan Potrč, and Arpad Ivanecz

Subjects
bleeding, emergency liver resection, hepatocellular carcinoma, metabolic syndrome, spontaneous rupture, surveillance, Medicine, Medicine (General), R5-920
Abstract

Key Clinical Message Hepatocellular carcinoma (HCC) develops in the presence of chronic liver disease, and nonalcoholic fatty liver disease is becoming a frequent cause of HCC in developed regions. Spontaneous rupture of HCC (rHCC) is a potentially life‐threatening complication of a tumor. The patient's compliance with surveillance after liver resection is vital for the prevention of rHCC.

Published
2019
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18. Are the current difficulty scores for laparoscopic liver surgery telling the whole story? An international survey and recommendations for the future

Author

Abu Hilal, M., Aldrighetti, L., Al Saati, H., Alseidi, A., Aroori, S., Belli, G., Besselink, M., Edwin, B., D'Hondt, M., Dagher, I., Dejong, C., Geller, D., Hamady, Z., Hamoui, M., Isaksson, B., Ivanecz, A., Le Roux, G., Lesurtel, M., O'Rouke, N., Prasad, R., Prieto Calvo, M., Reddy, S., Rotellar, F., Santoyo, J., Soonawalla, Z., Soubrane, O., Stavrou, G., Subar, D., Sutcliffe, R., Tanis, P., Troisi, R., Van Dam, Ronald, Wakabayashi, G., White, S., Halls, Mark C., Cherqui, Daniel, Taylor, Mark A., Primrose, John N., and Abu Hilal, Mohammed

Published
2018
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19. Laparoscopic anatomical liver resection after complex blunt liver trauma: a case report

Author

Arpad Ivanecz, Vid Pivec, Bojan Ilijevec, Saša Rudolf, and Stojan Potrč

Subjects
Laparoscopic, Anatomical liver resection, Blunt liver trauma, Complications, Bile leak, Surgery, RD1-811
Abstract

Abstract Background Various minimally invasive therapies are important adjuncts to management of hepatic injuries. However, there is a certain subset of patients who will benefit from liver resection, but there are no reports in the literature on laparoscopic anatomical liver resection for the management of complications after blunt liver trauma. Case presentation A 20-year-old male was admitted to the Emergency Unit of a tertiary referral center following a car accident. The patient was hemodynamically stable, and a radiologic workup demonstrated an isolated grade 3 injury of the left hemiliver. Initially, a nonoperative management was indicated, but during days following the injury, a high-volume biliary fistula complicated the clinical course. Despite percutaneous drainage, the development of devastating consequences of biliary peritonitis was imminent. A pure laparoscopic anatomical liver resection was performed. Left lateral sectionectomy eliminated the source of bile leak, and the surgery was completed with abdominal cavity lavage. Postoperative outcome was uneventful, and the patient was discharged on day 9 after injury and day 4 after surgery returning to his normal activity. Conclusions In highly selected, hemodynamically stable patients with no other life-threatening concomitant injuries, laparoscopic liver resection in elective setting is feasible and safe for the management of complications after complex blunt trauma of the left liver. Extensive experience with hepatic surgery is needed, and surgeons should understand the increased risk they assume by taking on more complex surgical techniques.

Published
2018
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20. Results from the European Survey on Preoperative Management and Optimization protocols for PeriHilar Cholangiocarcinoma

Author

Ratti, Francesca, primary, Marino, Rebecca, additional, Muiesan, Paolo, additional, Zieniewicz, Krzysztof, additional, Van Gulik, Tomas, additional, Guglielmi, Alfredo, additional, Marques, Hugo Pinto, additional, Andres, Valdivieso, additional, Schnitzbauer, Andreas, additional, Irinel, Popescu, additional, Schmelzle, Moritz, additional, Sparrelid, Ernesto, additional, Fusai, Giuseppe Kito, additional, Adam, Renè, additional, Cillo, Umberto, additional, Lang, Hauke, additional, Oldhafer, Karl, additional, Ruslan, Alikhanov, additional, Ciria, Ruben, additional, Ferrero, Alessandro, additional, Mazzaferro, Vincenzo, additional, Cescon, Matteo, additional, Giuliante, Felice, additional, Nadalin, Silvio, additional, Golse, Nicolas, additional, Sulpice, Laurent, additional, Serrablo, Alejandro, additional, Ramos, Emilio, additional, Marchese, Ugo, additional, Rosok, Bard, additional, Lopez-Lopez, Victor, additional, Clavien, Pierre, additional, Aldrighetti, Luca, additional, Sutcliffe, Robert, additional, Olthof, Pim, additional, Ruzzenente, Andrea, additional, Botea, Florin, additional, Gringeri, Enrico, additional, Bartsch, Fabian, additional, Russolillo, Nadia, additional, Sposito, Carlo, additional, Serenari, Matteo, additional, Ardito, Francesco, additional, Garnier, Jonathan, additional, Fretland, Asmund, additional, Ivanecz, Arpad, additional, Scatton, Olivier, additional, Lukashenko, Andrii, additional, Ben, Santi Lopez, additional, Lopez Bravo, Miguel Angel, additional, Siriwardena, Ajith, additional, Schiesser, Marc, additional, Jovine, Elio, additional, Koerkamp, Bas Groot, additional, Soubrane, Olivier, additional, Dejong, Cornelis HC., additional, Muscari, Fabrice, additional, Trudnikov, Andre, additional, Sallinen, Ville, additional, Sandstrom, Par, additional, Barauskas, Giedrius, additional, Pudil, Jiri, additional, Bjornsson, Bergthor, additional, Schwarz, Lilian, additional, Schadde, Erik, additional, Gruenberger, Thomas, additional, Rotellar, Fernando, additional, Christos, Dervenis, additional, Treska, Vladislav, additional, Fuks, David, additional, Schmidt, Jan, additional, Can, Fatih M., additional, Aranda, Fernando Pardo, additional, and Solecki, Michal, additional

Published
2023
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21. Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study

Author

Moody, Frank G., Bertrand, Claude, Johnson, Colin, van Lander, Aude, Carter, Ross, Conneely, John B., Berrevoet, Frederik, Sousa Silva, Donzília, Li, Zong-Fang, Lévy, Philippe, Oppong, Kofi, Gardner, Timothy B., Wilcox, C. Mel, French, Jeremy, Steer, Michael, Bradley, Edward L., III, Layer, Peter, Napoleon, Bertrand, Mosquera, Jorge Antonio, Gouma, D.J., Andersson, Roland, Manzelli, Antonio, Klaase, J.M., Falconi, Massimo, de-Madaria, Enrique, Casadei, Riccardo, Malleo, Giuseppe, Pezzilli, Raffaele, Malecka-Panas, Ewa, Lohr, Matthias, Mayerle, Julia, Rauws, Erik A.J., Freeman, Martin L., Ariffin, Affirul Chairil, Vasavada, Bhavin, Lai, Paul Bo-San, Beristain-Hernandez, Jose Luis, Juan, Álvarez, Plaudis, Haralds, Vrochides, Dionisios, Neri, Vincenzo, Velayutham, Vimalraj, Andrianov, Aleksey, Figueras, Joan, Soreide, Kjetil, Shcherba, Aliaksei, Gachabayov, Mahir, Keith, Roger G., Tsoulfas, Georgios, Fink, Michael Anthony, Crippa, Stefano, Nikfarjam, Mehrdad, Bora, Dibyajyoti, Desai, Rajendra, Donati, Marcello, Bong, Jan Jin, Martínez Moneo, Emma, Morris-Stiff, Gareth, Coker, Ahmet, de Resende, Alexandre Prado, Bhalerao, Suryabhan Sakhahari, Sikora, Sadiq S., Kelemen, Dezső, Czakó, László, Ramesh, Hariharan, Rummo, Oleg, Fedaruk, Aliaksei, Hlinnik, Alexey, Chinthakindi, Madhusudhan, Dumitrascu, Traian, Egorov, Vyacheslav, Bettschart, Vincent, Molinari, Michele, Guillermo, E. Aldana D., Orloff, Susan L., Kostov, Daniel Vasilev, Sulpice, Laurent, Knowles, Brett, Kimura, Yasutoshi, Marangoni, Gabriele, Joshi, Rajeev, Gyökeres, Tibor, Bedin, Vladimir, V., Ivanecz, Arpad, Antonucci, Adelmo, Omoshoro-Jones, Jones A.O., Nakache, Richard, Del Chiaro, Marco, Johnstone, Marianne, Saito, Tomoaki, Balzano, Gianpaolo, Chooklin, Serge, Boraschi, Piero, Park, Walter, Pereira, Pedro Nuno Valente Reis, Pagano, Nico, Lykoudis, Pavlos, Partecke, Lars Ivo, Siatkouski, Aliaksandr, Martín, Rosa Jorba, Kawabata, Yasunari, Lourenço, Luís Carvalho, Marra-Lopez, Carlos, Lee, Jun Kyu, Habbe, Nils, Verdonk, Robert C., Rabotyagova, Yliya, Talukdar, Rupjyoti, Frulloni, Luca, Galeev, Shamil, Berger, Zoltán, Yasuda, Takeo, Hackert, Thilo, Saatov, Ziyovuddin, Raptis, Dimitri Aristotle, Boadas, Jaume, Vitali, Francesco, Archibugi, Livia, Ryska, Miroslav, Tihanyi, Balazs, Singh, Vikesh K., Masamune, Atsushi, Yeaton, Paul, Smith, Kerrington D., Modi, Shrey, Cosen-Binker, Laura, Barreto, Savio George, Morandi, Eugenio, Valeri, Sergio, Morioka, Cintia Yoko, Lara, Luis F., Takeyama, Yoshifumi, Gress, Frank G., Yu, Young-Dong, Gaia, Ezio, Barbu, Sorin Traian, İnce, Ali Tüzün, Deeprasertvit, Akkraporn, Chang, Yu-Ting, Abiola, Stephen Olusola, Kacar, Sabite, Muscarella, Peter, II, Braat, Henri, Han, Samuel, Aghdassi, Ali A., Frossard, Jean-Louis, Smith, Jill P., Schwartz, M.P., van Dullemen, H.M., Venneman, N.G., Spanier, B.W.M., Kuiken, Sjoerd, van Geenen, Erwin, Beilman, Greg, Papachristou, Georgios, Chapa Azuela, Oscar, van der Schaar, P., Oruc, Nevin, Anten, Marie-Paule, Nealon, William H., García-Cano, Jesús, Jovani, Manol, Melki, Ziad, Ibrahim, Mustafa Mohammed Ahmed, Awajdarip, M.U., Azam, Mohammad, Sabu, K.G., Ermolaev, Igor, Shetty, Shiran, Oana, Belei, Pokrotnieks, Juris, Lazuchiewicz-Kot, Malgorzata, Bouali, Riadh, Winiarski, Marek, Schmitt, Marcus, Rimbas, Mihai, Meining, Alexander, Erwan, Bories, Meier, Peter N., Schoefl, Rainer, Altonbary, Ahmed Youssef, Marsteller, Igor, Wallstabe, Ingo, Prifti, Skerdi, Lemmers, Arnaud, Horvath, M., Kumar, Ajay, Palermo, Joseph J., Issa, Yama, van Santvoort, Hjalmar C., Fockens, Paul, Besselink, Marc G., Bollen, Thomas L., Bruno, Marco J., and Boermeester, Marja A.

Published
2017
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22. Simultaneous pure laparoscopic resection of primary colorectal cancer and synchronous liver metastases: a single institution experience with propensity score matching analysis

Author

Ivanecz Arpad, Krebs Bojan, Stozer Andraz, Jagric Tomaz, Plahuta Irena, and Potrc Stojan

Subjects
colorectal cancer, synchronous liver metastases, laparoscopy, liver resection, colorectal resection, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The aim of the study was to compare the outcome of pure laparoscopic and open simultaneous resection of both the primary colorectal cancer and synchronous colorectal liver metastases (SCLM).

Published
2017
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23. Impact factors for perioperative morbidity and mortality and repercussion of perioperative morbidity and long-term survival in pancreatic head resection

Author

Potrc Stojan, Ivanecz Arpad, Pivec Vid, Marolt Urska, Rudolf Sasa, Iljevec Bojan, and Jagric Tomaz

Subjects
pancreatic resections, complications, impact factors, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The focus of the present study was to reveal any impact factors for perioperative morbidity and mortality as well as repercussion of perioperative morbidity on long-term survival in pancreatic head resection.

Published
2017
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24. Outcomes of the surgical treatment for adenocarcinoma of the cardia – single institution experience

Author

Potrc Stojan, Ivanecz Arpad, Krebs Bojan, Marolt Urska, Iljevec Bojan, and Jagric Tomaz

Subjects
proximal gastric cancer, transhiatal resection, complications, survival, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Adenocarcinomas at the cardia are biologically aggressive tumors with poor long-term survival following curative resection. For resectable adenocarcinoma of the cardia, mostly esophagus extended total gastrectomy or esophagus extended proximal gastric resection is performed; however, the surgical approach, transhiatal or transthoracic, is still under discussion. Postoperative morbidity, mortality and long-term survival were analyzed to evaluate the potential differences in clinically relevant outcomes.

Published
2017
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25. Achievements in surgical treatment for colorectal liver metastases from 2000 until 2020

Author

Irena Plahuta, Tomislav Magdalenić, Špela Turk, Stojan Potrč, and Arpad Ivanecz

Abstract

Namen: Rak debelega črevesa in danke (RDČD) je v svetovnem merilu tretja najpogostejša maligna bolezen in najpogosteje zaseva v jetra. Namen raziskave je predstaviti možnosti kirurškega zdravljenja jetrnih zasevkov in rezultate zdravljenja. Metode: Opravili smo retrospektivni pregled prospektivno vodene datoteke resekcij jetrnih zasevkov RDČD na Kliničnem oddelku za abdominalno in splošno kirurgijo Univerzitetnega kliničnega centra Maribor. Raziskava temelji na principu pristopa k zdravljenju z namenom ozdravitve. Analizirali smo število posegov, ponovne posege, zaplete in preživetje. Rezultati: Od januarja 2000 do decembra 2020 je bilo izvedenih 631 kirurških posegov zaradi jetrnih zasevkov RDČD. 352 (74,4 %) bolnikov je bolnikov več kot enega. Resekcij jeter je bilo 541 (85,7 %), in sicer 389 manjših in 152 velikih resekcij. Radiofrekvenčno ablacijo smo opravili v 61 (9,7 %) in eksploracijo v 29 (4,6 %) primerih. Ponovnih posegov je bilo 138 (21,9 %). Hudi zapleti (stopnja ≥ 3a po klasifikaciji Clavien-Dindo) so se pojavili po 84 (13,3 %) posegih. 90-dnevna pooperativna smrtnost je znašala 3,8 %. Mediano preživetje pri seštevku 0 v Clinical Risk Score je 69 mesecev; 5- in 10-letni preživetji sta 57-% oziroma 38-%. Zaključek: Kirurška odstranitev jetrnih zasevkov v celoti in ugodni prognostični dejavniki omogočajo dolgoročno preživetje bolnikov z jetrnimi zasevki RDČD.

Published
2022
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26. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Balakrishnan, Anita, primary, Barmpounakis, Petros, additional, Demiris, Nikolaos, additional, Jah, Asif, additional, Spiers, Harry V.M., additional, Talukder, Shibojit, additional, Martin, Jack L., additional, Gibbs, Paul, additional, Harper, Simon J.F., additional, Huguet, Emmanuel L., additional, Kosmoliaptsis, Vasilis, additional, Liau, Siong S., additional, Praseedom, Raaj K., additional, Basu, Bristi, additional, de Aretxabala, Xavier, additional, Lendoire, Javier, additional, Maithel, Shishir, additional, Branes, Alejandro, additional, Andersson, Bodil, additional, Serrablo, Alejandro, additional, Adsay, Volkan, additional, Abe, Tomoyuki, additional, Abu Hilal, Moh'd, additional, Achalandabaso Boira, Maria del Mar, additional, Adham, Mustapha, additional, Adam, Mohamed, additional, Ahmad, Maryam, additional, Al-Sarireh, Bilal, additional, Albiol, Maite, additional, Alhaboob, Nassir, additional, Alseidi, Adnan, additional, Ammar, Houssem, additional, Anand, Akshay, additional, Antonakis, Pantelis, additional, Araya, Veronica, additional, Ashley, Stanley W., additional, Atanasov, Georgi, additional, Ausania, Fabio, additional, Balestri, Ricardo, additional, Banerjee, Abhirup, additional, Banerjee, Sudeep, additional, Banting, Simon, additional, Barauskas, Giedrius, additional, Bartsch, Fabian, additional, Belli, Andrea, additional, Beretta, Simona, additional, Berrevoet, Frederik, additional, Bhandari, Ramesh Singh, additional, Blanco Fernandez, Gerardo, additional, Bolm, Louisa, additional, Bonal, Mathieu, additional, Bozkurt, Emre, additional, Braat, Andries E., additional, Bradshaw, Luke, additional, Bramis, Konstantinos, additional, Burdine, Lyle, additional, Byrne, Matthew, additional, Caceres, Maria, additional, Castro Santiago, Maria Jesus, additional, Chan, Benjamin, additional, Chong, Lynn, additional, Çoker, Ahmet, additional, Conde Rodriguez, Maria, additional, Croagh, Daniel, additional, Crutchley, Alyn, additional, Cutolo, Carmen, additional, D'Hondt, Mathieu, additional, D'Souza, Daniel, additional, Daams, Freek, additional, Dalla Valle, Raffaele, additional, Davide, José, additional, de Bellis, Mario, additional, de Boer, Marieke, additional, de Meyere, Celine, additional, de Reuver, Philip, additional, Dixon, Matthew, additional, Dorovinis, Panagiotis, additional, Echeverría Bauer, Gabriela, additional, Eduarda, Maria, additional, Eker, Hasan, additional, Erdmann, Joris, additional, Erkan, Mert, additional, Felekouras, Evangelos, additional, Felli, Emanuele, additional, Fernandes, Eduardo, additional, Figueroa Rivera, Eduardo, additional, Fulop, Andras, additional, Galun, Daniel, additional, Gerhards, Michael, additional, Ghorbani, Poya, additional, Giannone, Fabio, additional, Gil, Luis, additional, Giorgakis, Emmanouil, additional, Giuffrida, Mario, additional, Giuliante, Felice, additional, Gkekas, Ioannis, additional, Gomez Bravo, Miguel, additional, Groot Koerkamp, Bas, additional, Guevara, Oscar, additional, Guglielmi, Alfredo, additional, Gulla, Aiste, additional, Gupta, Rahul, additional, Gupta, Amit, additional, Gutiérrez, Marta, additional, Hafeez Bhatti, Abu Bakar, additional, Hagendoorn, Jeroen, additional, Hajee, Zain, additional, Hakeem, Abdul Rahman, additional, Hamid, Hytham, additional, Hassen, Sayed, additional, Heinrich, Stefan, additional, Higuchi, Ryota, additional, Hoffman, Daniel, additional, Holroyd, David, additional, Hughes, Daniel, additional, Ivanecz, Arpad, additional, Iype, Satheesh, additional, Jaen Torrejimeno, Isabel, additional, Joglekar, Shantanu, additional, Jones, Robert, additional, Kaczirek, Klaus, additional, Kanhere, Harsh, additional, Kausar, Ambareen, additional, Kee, Zhanyi, additional, Keilson, Jessica, additional, Kleef, Jorg, additional, Klose, Johannes, additional, Knowles, Brett, additional, Koong, Jun Kit, additional, Kumar, Nagappan, additional, Kunnuru, Supreeth, additional, Lakhey, Paleswan Joshi, additional, Laurenzi, Andrea, additional, Lee, Yeong Sing, additional, Leon, Felipe, additional, Leow, Voon Meng, additional, Lequeu, Jean-Baptiste, additional, Lesurtel, Mickael, additional, Lo, Elisabeth, additional, Löb, Stefan, additional, Lockie, Elizabeth, additional, Lodge, Peter, additional, López Garnica, Dolores, additional, Lopez Lopez, Victor, additional, Lundgren, Linda, additional, Machairas, Nikolaos, additional, Maharjan, Dhiresh, additional, Malde, Deep, additional, Martel, Guillaume, additional, Martin, Julie, additional, Mazzola, Michele, additional, Mehrabi, Arianeb, additional, Memeo, Ricardo, additional, Milana, Flavio, additional, Molina, George, additional, Monette, Leah, additional, Morgul, Haluk, additional, Moris, Dimitrios, additional, Morsi-Yeroyannis, Antonios, additional, Mowbray, Nicholas, additional, Mulita, Francesk, additional, Muttillo, Edoardo Maria, additional, Nandasena, Malith, additional, Nashidengo, Pueya Rashid, additional, Nickkholgh, Arash, additional, Noel, Colin Byron, additional, Ohtsuka, Masayuki, additional, Ozolins, Arturs, additional, Pandanaboyana, Sanjay, additional, Pararas, Nikolaos, additional, Parente, Alessandro, additional, Peng, June, additional, Perfecto Valero, Arkaitz, additional, Perinel, Julie, additional, Perivoliotis, Konstatinos, additional, Perra, Teresa, additional, Pessaux, Patrick, additional, Petruch, Natalie, additional, Piccolo, Gaetano, additional, Piros, Laszlo, additional, Porcu, Alberto, additional, Prabakaran, Viswakumar, additional, Prasad, Raj, additional, Prieto Calvo, Mikel, additional, Primavesi, Florian, additional, Pueyo Periz, Eva Maria, additional, Quaglia, Alberto, additional, Ramia Angel, Jose M., additional, Rammohan, Ashwin, additional, Razionale, Francesco, additional, Robles Campos, Ricardo, additional, Roy, Manas, additional, Rozwadowski, Sophie, additional, Ruffolo, Luis, additional, Ruiz, Natalia, additional, Ruzzenante, Andrea, additional, Saadat, Lily, additional, Said, Mohamed Amine, additional, Saladino, Edoardo, additional, Saliba, Gabriel, additional, Sandstrom, Per, additional, Schena, Carlo Alberto, additional, Scholer, Anthony, additional, Schwarz, Christoph, additional, Serafini, Lorenzo, additional, Serrano, Pablo E., additional, Sharma, Deepak, additional, Sheen, Aali, additional, Siddagangaiah, Vishwanath, additional, Silva, Michael, additional, Singh, Saurabh, additional, Siriwardena, Ajith, additional, Skalski, Michal, additional, Smig, Mante, additional, Soliman, Faris, additional, Sonkar, Abhinav Arun, additional, Sousa Silva, Donzília, additional, Sparrelid, Ernesto, additional, Srinivasan, Parthi, additional, Sternby Eilard, Malin, additional, Strobel, Oliver, additional, Stupan, Urban, additional, Suarez-Munoz, Miguel Angel, additional, Subramaniam, Manisekar, additional, Sugiura, Teiichi, additional, Sutcliffe, Robert, additional, Swank, Hilko, additional, Taylor, Lillian, additional, Thapa, Prabin Bikram, additional, The, Catherine, additional, Thepbunchonchai, Asara, additional, Thieu, Caman, additional, Tiwari, Navneet, additional, Torzilli, Guido, additional, Tovikkai, Chutwichai, additional, Trotovsek, Blaz, additional, Tsaramanidis, Savvas, additional, Tsoulfas, Georgios, additional, Uesaka, Katsuhiko, additional, Umar, Garzali, additional, Urbani, Lucio, additional, Vailas, Michail, additional, van Dam, Ronald, additional, van de Boezem, Peter, additional, van Laarhoven, Stijn, additional, Vanagas, Tomas, additional, Van Dooren, Mike, additional, Viennet, Manon, additional, Vigano, Luca, additional, Vijayashanker, Aarathi, additional, Villodre, Celia, additional, Wakai, Toshifumi, additional, Workneh, Aklile, additional, Xu, Li, additional, Yamamoto, Masakazu, additional, Yang, Zhiying, additional, Young, Robert, additional, and Zivanovic, Marko, additional

Published
2023
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27. Impact of neoadjuvant chemotherapy on the difficulty and outcomes of laparoscopic and robotic major liver resections for colorectal liver metastases: A propensity-score and coarsened exact-matched controlled study

Author

Ghotbi, J., Aghayan, D., Fretland, A., Edwin, B., Syn, N. L., Cipriani, F., Alzoubi, M., Lim, C., Scatton, O., Long, T. C. D., Herman, P., Coelho, F. F., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. -H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Yin, M., Fondevila, C., Efanov, M., Morise, Z., Di Benedetto, F., Brustia, R., Dalla Valle, R., Boggi, U., Geller, D., Belli, A., Memeo, R., Mejia, A., Park, J. O., Rotellar, F., Choi, G. -H., Robles-Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Tang, C. -N., Chong, C. C. N., D'Hondt, M., Monden, K., Lopez-Ben, S., Kingham, T. P., Ferrero, A., Ettorre, G. M., Levi Sandri, G. B., Pascual, F., Cherqui, D., Liang, X., Mazzotta, A., Wakabayashi, G., Giglio, M., Troisi, R. I., Han, H. -S., Cheung, T. -T., Sugioka, A., Chen, K. -H., Liu, R., Soubrane, O., Fuks, D., Aldrighetti, L., Abu Hilal, M., Goh, B. K. P., Gastaca, M., Meurs, J., De Meyere, C., Lee, K. -F., Ng, K. K., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Kato, Y., Kojima, M., Pirola Kruger, J. A., Lopez-Lopez, V., Casellas I Robert, M., Montalti, R., Lee, B., D'Silva, M., Wang, H. -P., Saleh, M., Chen, Z., Yu, S., Vani, S., Ardito, Francesco, Giustizieri, U., Citterio, D., Mocchegiani, F., Colasanti, M., Guzman, Y., Labadie, K. P., Conticchio, M., Dogeas, E., Kauffmann, E. F., Giuffrida, M., Sommacale, D., Laurent, A., Magistri, P., Nghia, P. P., Mishima, K., Valle, B. D., Krenzien, F., Schmelzle, M., Kadam, P., Liu, Q., Lai, E. C. H., Zheng, J., Siow, T. F., Forchino, F., Giuliante F. (ORCID:0000-0001-9517-8220), Ardito F. (ORCID:0000-0003-1596-2862), Ghotbi, J., Aghayan, D., Fretland, A., Edwin, B., Syn, N. L., Cipriani, F., Alzoubi, M., Lim, C., Scatton, O., Long, T. C. D., Herman, P., Coelho, F. F., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. -H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Yin, M., Fondevila, C., Efanov, M., Morise, Z., Di Benedetto, F., Brustia, R., Dalla Valle, R., Boggi, U., Geller, D., Belli, A., Memeo, R., Mejia, A., Park, J. O., Rotellar, F., Choi, G. -H., Robles-Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Tang, C. -N., Chong, C. C. N., D'Hondt, M., Monden, K., Lopez-Ben, S., Kingham, T. P., Ferrero, A., Ettorre, G. M., Levi Sandri, G. B., Pascual, F., Cherqui, D., Liang, X., Mazzotta, A., Wakabayashi, G., Giglio, M., Troisi, R. I., Han, H. -S., Cheung, T. -T., Sugioka, A., Chen, K. -H., Liu, R., Soubrane, O., Fuks, D., Aldrighetti, L., Abu Hilal, M., Goh, B. K. P., Gastaca, M., Meurs, J., De Meyere, C., Lee, K. -F., Ng, K. K., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Kato, Y., Kojima, M., Pirola Kruger, J. A., Lopez-Lopez, V., Casellas I Robert, M., Montalti, R., Lee, B., D'Silva, M., Wang, H. -P., Saleh, M., Chen, Z., Yu, S., Vani, S., Ardito, Francesco, Giustizieri, U., Citterio, D., Mocchegiani, F., Colasanti, M., Guzman, Y., Labadie, K. P., Conticchio, M., Dogeas, E., Kauffmann, E. F., Giuffrida, M., Sommacale, D., Laurent, A., Magistri, P., Nghia, P. P., Mishima, K., Valle, B. D., Krenzien, F., Schmelzle, M., Kadam, P., Liu, Q., Lai, E. C. H., Zheng, J., Siow, T. F., Forchino, F., Giuliante F. (ORCID:0000-0001-9517-8220), and Ardito F. (ORCID:0000-0003-1596-2862)

Abstract

Background: Minimal invasive liver resections are a safe alternative to open surgery. Different scoring systems considering different risks factors have been developed to predict the risks associated with these procedures, especially challenging major liver resections (MLR). However, the impact of neoadjuvant chemotherapy (NAT) on the difficulty of minimally invasive MLRs remains poorly investigated. Methods: Patients who underwent laparoscopic and robotic MLRs for colorectal liver metastases (CRLM) performed across 57 centers between January 2005 to December 2021 were included in this analysis. Patients who did or did not receive NAT were matched based on 1:1 coarsened exact and 1:2 propensity-score matching. Pre- and post-matching comparisons were performed. Results: In total, the data of 5189 patients were reviewed. Of these, 1411 procedures were performed for CRLM, and 1061 cases met the inclusion criteria. After excluding 27 cases with missing data on NAT, 1034 patients (NAT: n = 641; non-NAT: n = 393) were included. Before matching, baseline characteristics were vastly different. Before matching, the morbidity rate was significantly higher in the NAT-group (33.2% vs. 27.2%, p-value = 0.043). No significant differences were seen in perioperative outcomes after the coarsened exact matching. After the propensity-score matching, statistically significant higher blood loss (mean, 300 (SD 128–596) vs. 250 (SD 100–400) ml, p-value = 0.047) but shorter hospital stay (mean, 6 [4-8] vs. 6 [5-9] days, p-value = 0.043) were found in the NAT-group. Conclusion: The current study demonstrated that NAT had minimal impact on the difficulty and outcomes of minimally-invasive MLR for CRLM.

Published
2023

28. Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

Author

Goh, B. K. P., Han, H. -S., Chen, K. -H., Chua, D. W., Chan, C. -Y., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., D'Silva, M., Siow, T. F., Kato, Y., Lim, C., Nghia, P. P., Herman, P., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Gastaca, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Yin, M., Chen, Z., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Campos, R. R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Coelho, F. F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Sandri, G. B. L., Saleh, M., Cherqui, D., Scatton, O., Soubrane, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Hilal, M. A., Fuks, D., Edwin, B., Aldrighetti, L., Syn, N., Prieto, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Kojima, M., Ghotbi, J., Kruger, J. A. P., Lopez-Lopez, V., Valle, B. D., Casellas I Robert, M., Mishima, K., Montalti, R., Giglio, M., Mazzotta, A., Lee, B., Wang, H. -P., Pascual, F., Kadam, P., Tang, C. -N., Yu, S., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Giuliante F. (ORCID:0000-0001-9517-8220), Ardito F. (ORCID:0000-0003-1596-2862), Goh, B. K. P., Han, H. -S., Chen, K. -H., Chua, D. W., Chan, C. -Y., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., D'Silva, M., Siow, T. F., Kato, Y., Lim, C., Nghia, P. P., Herman, P., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Gastaca, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Yin, M., Chen, Z., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Campos, R. R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Coelho, F. F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Sandri, G. B. L., Saleh, M., Cherqui, D., Scatton, O., Soubrane, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Hilal, M. A., Fuks, D., Edwin, B., Aldrighetti, L., Syn, N., Prieto, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Kojima, M., Ghotbi, J., Kruger, J. A. P., Lopez-Lopez, V., Valle, B. D., Casellas I Robert, M., Mishima, K., Montalti, R., Giglio, M., Mazzotta, A., Lee, B., Wang, H. -P., Pascual, F., Kadam, P., Tang, C. -N., Yu, S., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Giuliante F. (ORCID:0000-0001-9517-8220), and Ardito F. (ORCID:0000-0003-1596-2862)

Abstract

Objective: To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR). Background: There is limited published data to date on the best achievable outcomes after L-LR. Methods: This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs. Results: There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively. Conclusions: This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the "best achievable" results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.

Published
2023

29. Comparison between the difficulty of laparoscopic limited liver resections of tumors located in segment 7 versus segment 8: An international multicenter propensity-score matched study

Author

Efanov, M., Salimgereeva, D., Alikhanov, R., Wu, A. G. R., Geller, D., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., Belli, A., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Fondevila, C., Rotellar, F., Choi, G. -H., Robless Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Herman, P., Di Benedetto, F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Levi Sandri, G. B., Cherqui, D., Scatton, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Han, H. -S., Abu Hilal, M., Soubrane, O., Fuks, D., Aldrighetti, L., Edwin, B., Goh, B. K. P., Chan, C. -Y., Syn, N., D'Silva, M., Lee, B., Lim, C., Nghia, P. P., Gastaca, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Lee, L. S., Jang, J. Y., Kojima, M., Kato, Y., Ghotbi, J., Kruger, J. A. P., Coelho, F. F., Lopez-Lopez, V., Valle, B. D., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Wang, H. -P., Pascual, F., Saleh, M., Kadam, P., Tang, C. -N., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Dogeas, E., Magistri, P., Mazzotta, A., Giuliante F. (ORCID:0000-0001-9517-8220), Ardito F. (ORCID:0000-0003-1596-2862), Efanov, M., Salimgereeva, D., Alikhanov, R., Wu, A. G. R., Geller, D., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., Belli, A., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Fondevila, C., Rotellar, F., Choi, G. -H., Robless Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Herman, P., Di Benedetto, F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Levi Sandri, G. B., Cherqui, D., Scatton, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Han, H. -S., Abu Hilal, M., Soubrane, O., Fuks, D., Aldrighetti, L., Edwin, B., Goh, B. K. P., Chan, C. -Y., Syn, N., D'Silva, M., Lee, B., Lim, C., Nghia, P. P., Gastaca, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Lee, L. S., Jang, J. Y., Kojima, M., Kato, Y., Ghotbi, J., Kruger, J. A. P., Coelho, F. F., Lopez-Lopez, V., Valle, B. D., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Wang, H. -P., Pascual, F., Saleh, M., Kadam, P., Tang, C. -N., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Dogeas, E., Magistri, P., Mazzotta, A., Giuliante F. (ORCID:0000-0001-9517-8220), and Ardito F. (ORCID:0000-0003-1596-2862)

Abstract

Background: Presently, according to different difficulty scoring systems, there is no difference in complexity estimation of laparoscopic liver resection (LLR) of segments 7 and 8. However, there is no published data supporting this assumption. To date, no studies have compared the outcomes of laparoscopic parenchyma-sparing resection of the liver segments 7 and 8. Methods: A post hoc analysis of patients undergoing LLR of segments 7 and 8 in 46 centers between 2004 and 2020 was performed. 1:1 Propensity score matching (PSM) was used to compare isolated LLR of segments 7 and 8. Subset analyses were also performed to compare atypical resections and segmentectomies of 7 and 8. Results: A total of 2411 patients were identified, and 1691 patients met the inclusion criteria. Comparison after PSM between the entire cohort of segment 7 and segment 8 resections revealed inferior results for segment 7 resection in terms of increased blood loss, blood transfusions, and conversions to open surgery. Subset analyses of only atypical resections similarly demonstrated poorer outcomes for segment 7 in terms of increased blood loss, operation time, blood transfusions, and conversions to open surgery. Conversely, a subgroup analysis of segmentectomies after PSM found better outcomes for segment 7 in terms of a shorter operation time and hospital stay. Conclusion: Differences in the outcomes of segments 7 and 8 resections suggest a greater difficulty of laparoscopic atypical resection of segment 7 compared to segment 8, and greater difficulty of segmentectomy 8 compared to segmentectomy 7.

Published
2023

30. Laparoscopic versus open right posterior sectionectomy: an international, multicenter, propensity score-matched evaluation

Author

Mehmet F Can, Mohammed Abu Hilal, Paolo Magistri, Luca Aldrighetti, Mathieu D'Hondt, Francesca Ratti, Fabrizio Di Benedetto, M. Papoulas, Arpad Ivanecz, Marc G. Besselink, Marco Vivarelli, Andrea Benedetti Cacciaguerra, Krishna Menon, Nicky van der Heijde, van der Heijde, N., Ratti, F., Aldrighetti, L., Benedetti Cacciaguerra, A., Can, M. F., D'Hondt, M., Di Benedetto, F., Ivanecz, A., Magistri, P., Menon, K., Papoulas, M., Vivarelli, M., Besselink, M. G., Abu Hilal, M., Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Laparoscopic surgery, medicine.medical_specialty, Surgical procedure, medicine.medical_treatment, Operative Time, Malignancy, Article, Postoperative Complications, Minimally invasive surgery, Internal medicine, Propensity score matching, medicine, Clinical endpoint, Hepatectomy, Humans, Propensity Score, Liver surgery, Retrospective Studies, business.industry, Liver Neoplasms, Retrospective cohort study, Hepatology, Length of Stay, medicine.disease, Operative outcomes, Surgery, Treatment Outcome, Right posterior, Laparoscopy, business, Abdominal surgery
Abstract

Background Although laparoscopic liver resection has become the standard for minor resections, evidence is lacking for more complex resections such as the right posterior sectionectomy (RPS). We aimed to compare surgical outcomes between laparoscopic (LRPS) and open right posterior sectionectomy (ORPS). Methods An international multicenter retrospective study comparing patients undergoing LRPS or ORPS (January 2007—December 2018) was performed. Patients were matched based on propensity scores in a 1:1 ratio. Primary endpoint was major complication rate defined as Accordion ≥ 3 grade. Secondary endpoints included blood loss, length of hospital stay (LOS) and resection status. A sensitivity analysis was done excluding the first 10 LRPS patients of each center to correct for the learning curve. Additionally, possible risk factors were explored for operative time, blood loss and LOS. Results Overall, 399 patients were included from 9 centers from 6 European countries of which 150 LRPS could be matched to 150 ORPS. LRPS was associated with a shorter operative time [235 (195–285) vs. 247 min (195–315) p = 0.004], less blood loss [260 (188–400) vs. 400 mL (280–550) p = 0.009] and a shorter LOS [5 (4–7) vs. 8 days (6–10), p = 0.002]. Major complication rate [n = 8 (5.3%) vs. n = 9 (6.0%) p = 1.00] and R0 resection rate [144 (96.0%) vs. 141 (94.0%), p = 0.607] did not differ between LRPS and ORPS, respectively. The sensitivity analysis showed similar findings in the previous mentioned outcomes. In multivariable regression analysis blood loss was significantly associated with the open approach, higher ASA classification and malignancy as diagnosis. For LOS this was the open approach and a malignancy. Conclusion This international multicenter propensity score-matched study showed an advantage in favor of LRPS in selected patients as compared to ORPS in terms of operative time, blood loss and LOS without differences in major complications and R0 resection rate.

Published
2021
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31. Laparoscopic versus open resection of primary colorectal cancers and synchronous liver metastasis: a systematic review and meta-analysis

Author

Stefan Morarasu, Cillian Clancy, Emre Gorgun, Sumeyye Yilmaz, Arpad Ivanecz, Shoji Kawakatsu, Ana Maria Musina, Natalia Velenciuc, Cristian Ene Roata, Gabriel Mihail Dimofte, and Sorinel Lunca

Subjects
Gastroenterology
Abstract

Purpose Combined resection of primary colorectal cancer and associated liver metastases is increasingly common. This study compares peri-operative and oncological outcomes according to surgical approach. Methods The study was registered with PROSPERO. A systematic search was performed for all comparative studies describing outcomes in patients that underwent laparoscopic versus open simultaneous resection of colorectal primary tumours and liver metastases. Data was extracted and analysed using a random effects model via Rev Man 5.3 Results Twenty studies were included with a total of 2168 patients. A laparoscopic approach was performed in 620 patients and an open approach in 872. There was no difference in the groups for BMI (mean difference: 0.04, 95% CI: 0.63–0.70, p = 0.91), number of difficult liver segments (mean difference: 0.64, 95% CI:0.33–1.23, p = 0.18) or major liver resections (mean difference: 0.96, 95% CI: 0.69–1.35, p = 0.83). There were fewer liver lesions per operation in the laparoscopic group (mean difference 0.46, 95% CI: 0.13–0.79, p = 0.007). Laparoscopic surgery was associated with shorter length of stay (p Conclusion Synchronous laparoscopic resection of primary colorectal cancers and liver metastases is a feasible approach in selected patients and does not demonstrate inferior peri-operative or oncological outcomes.

Published
2023
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32. Factors associated with and impact of open conversion on the outcomes of minimally invasive left lateral sectionectomies: An international multicenter study

Author

Hao Ping Wang, Chee Chien Yong, Andrew G.R. Wu, Daniel Cherqui, Roberto I. Troisi, Federica Cipriani, Davit Aghayan, Marco V. Marino, Andrea Belli, Adrian K.H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Marco Vivarelli, Fabrizio Di Benedetto, Sung-Hoon Choi, Jae Hoon Lee, James O. Park, Mikel Gastaca, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung Ngai Tang, Charing C. Chong, Mathieu D’Hondt, Andrea Ruzzenente, Paolo Herman, T. Peter Kingham, Olivier Scatton, Rong Liu, Alessandro Ferrero, Giovanni Battista Levi Sandri, Olivier Soubrane, Alejandro Mejia, Santiago Lopez-Ben, Jasper Sijberden, Kazuteru Monden, Go Wakabayashi, Atsushi Sugioka, Tan-To Cheung, Tran Cong Duy Long, Bjorn Edwin, Ho-Seong Han, David Fuks, Luca Aldrighetti, Mohamed Abu Hilal, Brian K.P. Goh, Chung-Yip Chan, Nicholas Syn, Mikel Prieto, Henri Schotte, Celine De Meyere, Felix Krenzien, Moritz Schmelzle, Kit-Fai Lee, Diana Salimgereeva, Ruslan Alikhanov, Lip Seng Lee, Jae Young Jang, Kevin P. Labadie, Masayuki Kojima, Yutaro Kato, Asmund Avdem Fretland, Jacob Ghotbi, Fabricio Ferreira Coelho, Jaime Arthur Pirola Kruger, Victor Lopez-Lopez, Paolo Magistri, Bernardo Dalla Valle, Margarida Casellas I Robert, Kohei Mishima, Giuseppe Maria Ettorre, Federico Mocchegiani, Prashant Kadam, Franco Pascual, Mansour Saleh, Alessandro Mazzotta, Roberto Montalti, Mariano Giglio, Boram Lee, Mizelle D’Silva, Phan Phuoc Nghia, Chetana Lim, Qu Liu, Eric C. Lai, Wang, Hao Ping, Yong, Chee Chien, Wu, Andrew G R, Cherqui, Daniel, Troisi, Roberto I, Cipriani, Federica, Aghayan, Davit, Marino, Marco V, Belli, Andrea, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Vivarelli, Marco, Di Benedetto, Fabrizio, Choi, Sung-Hoon, Lee, Jae Hoon, Park, James O, Gastaca, Mikel, Fondevila, Constantino, Efanov, Mikhail, Rotellar, Fernando, Choi, Gi-Hong, Campos, Ricardo Roble, Wang, Xiaoying, Sutcliffe, Robert P, Pratschke, Johann, Tang, Chung Ngai, Chong, Charing C, D'Hondt, Mathieu, Ruzzenente, Andrea, Herman, Paolo, Kingham, T Peter, Scatton, Olivier, Liu, Rong, Ferrero, Alessandro, Levi Sandri, Giovanni Battista, Soubrane, Olivier, Mejia, Alejandro, Lopez-Ben, Santiago, Sijberden, Jasper, Monden, Kazuteru, Wakabayashi, Go, Sugioka, Atsushi, Cheung, Tan-To, Long, Tran Cong Duy, Edwin, Bjorn, Han, Ho-Seong, Fuks, David, Aldrighetti, Luca, Abu Hilal, Mohamed, Goh, Brian K P, Wang, H. P., Yong, C. C., Wu, A. G. R., Cherqui, D., Troisi, R. I., Cipriani, F., Aghayan, D., Marino, M. V., Belli, A., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Vivarelli, M., Di Benedetto, F., Choi, S. -H., Lee, J. H., Park, J. O., Gastaca, M., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Campos, R. R., Wang, X., Sutcliffe, R. P., Pratschke, J., Tang, C. N., Chong, C. C., D'Hondt, M., Ruzzenente, A., Herman, P., Kingham, T. P., Scatton, O., Liu, R., Ferrero, A., Levi Sandri, G. B., Soubrane, O., Mejia, A., Lopez-Ben, S., Sijberden, J., Monden, K., Wakabayashi, G., Sugioka, A., Cheung, T. -T., Long, T. C. D., Edwin, B., Han, H. -S., Fuks, D., Aldrighetti, L., Abu Hilal, M., Goh, B. K. P., Chan, C. -Y., Syn, N., Prieto, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. S., Jang, J. Y., Labadie, K. P., Kojima, M., Kato, Y., Fretland, A. A., Ghotbi, J., Coelho, F. F., Pirola Kruger, J. A., Lopez-Lopez, V., Magistri, P., Valle, B. D., Casellas I Robert, M., Mishima, K., Ettorre, G. M., Mocchegiani, F., Kadam, P., Pascual, F., Saleh, M., Mazzotta, A., Montalti, R., Giglio, M., Lee, B., D'Silva, M., Nghia, P. P., Lim, C., Liu, Q., Lai, E. C., Graduate School, Surgery, and CCA - Cancer Treatment and Quality of Life

Subjects
Male, Operative Time, Length of Stay, Conversion to Open Surgery, Hepatectomy, Humans, Minimally Invasive Surgical Procedures, Postoperative Complications, Retrospective Studies, Treatment Outcome, Hypertension, Portal, Laparoscopy, Neoplasms, Hypertension, Surgery, Portal
Abstract

Background: Despite the rapid advances that minimally invasive liver resection has gained in recent decades, open conversion is still inevitable in some circumstances. In this study, we aimed to determine the risk factors for open conversion after minimally invasive left lateral sectionectomy, and its impact on perioperative outcomes. Methods: This is a post hoc analysis of 2,445 of 2,678 patients who underwent minimally invasive left lateral sectionectomy at 45 international centers between 2004 and 2020. Factors related to open conversion were analyzed via univariate and multivariate analyses. One-to-one propensity score matching was used to analyze outcomes after open conversion versus non-converted cases. Results: The open conversion rate was 69/2,445 (2.8%). On multivariate analyses, male gender (3.6% vs 1.8%, P = .011), presence of clinically significant portal hypertension (6.1% vs 2.6%, P = .009), and larger tumor size (50 mm vs 32 mm, P < .001) were identified as independent factors associated with open conversion. The most common reason for conversion was bleeding in 27/69 (39.1%) of cases. After propensity score matching (65 open conversion vs 65 completed via minimally invasive liver resection), the open conversion group was associated with increased operation time, blood transfusion rate, blood loss, and postoperative stay compared with cases completed via the minimally invasive approach. Conclusion: Male sex, portal hypertension, and larger tumor size were predictive factors of open conversion after minimally invasive left lateral sectionectomy. Open conversion was associated with inferior perioperative outcomes compared with non-converted cases.

Published
2022

33. Utility of the Iwate difficulty scoring system for laparoscopic right posterior sectionectomy: do surgical outcomes differ for tumors in segments VI and VII?

Author

Choi S. H., Chen K. -H., Syn N. L., Cipriani F., Cheung T. -T., Chiow A. K. H., Choi G. -H., Siow T. -F., Sucandy I., Marino M. V., Gastaca M., Chong C. C., Lee J. H., Ivanecz A., Mazzaferro V., Lopez-Ben S., Fondevila C., Rotellar F., Campos R. R., Efanov M., Kingham T. P., Sutcliffe R. P., Troisi R. I., Pratschke J., Wang X., D'Hondt M., Yong C. C., Levi Sandri G. B., Tang C. N., Ruzzenente A., Cherqui D., Ferrero A., Wakabayashi G., Scatton O., Aghayan D., Edwin B., Coelho F. F., Giuliante F., Liu R., Sijberden J., Abu Hilal M., Sugioka A., Long T. C. D., Fuks D., Aldrighetti L., Han H. -S., Goh B. K. P., Kang I., Jang J. Y., Chan C. -Y., D'Silva M., Schotte H., De Meyere C., Lai E., Krenzien F., Schmelzle M., Kadam P., Montalti R., Giglio M., Liu Q., Lee K. -F., Salimgereeva D., Alikhanov R., Lee L. -S., Prieto M., Lim C., Nghia P. P., Kojima M., Kato Y., Forchino F., Herman P., Kruger J. A. P., Saleh M., Pascual F., Dalla Valle B., Lopez-Lopez V., Casellas-Robert M., Giustizieri U., Citterio D., Mishima K., Fretland A. A., Ghotbi J., Ettorre G. M., Colasanti M., Guzman Y., Ardito F., Vani S., Wang H. -P., Choi, S. H., Chen, K. -H., Syn, N. L., Cipriani, F., Cheung, T. -T., Chiow, A. K. H., Choi, G. -H., Siow, T. -F., Sucandy, I., Marino, M. V., Gastaca, M., Chong, C. C., Lee, J. H., Ivanecz, A., Mazzaferro, V., Lopez-Ben, S., Fondevila, C., Rotellar, F., Campos, R. R., Efanov, M., Kingham, T. P., Sutcliffe, R. P., Troisi, R. I., Pratschke, J., Wang, X., D'Hondt, M., Yong, C. C., Levi Sandri, G. B., Tang, C. N., Ruzzenente, A., Cherqui, D., Ferrero, A., Wakabayashi, G., Scatton, O., Aghayan, D., Edwin, B., Coelho, F. F., Giuliante, F., Liu, R., Sijberden, J., Abu Hilal, M., Sugioka, A., Long, T. C. D., Fuks, D., Aldrighetti, L., Han, H. -S., Goh, B. K. P., Kang, I., Jang, J. Y., Chan, C. -Y., D'Silva, M., Schotte, H., De Meyere, C., Lai, E., Krenzien, F., Schmelzle, M., Kadam, P., Montalti, R., Giglio, M., Liu, Q., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Prieto, M., Lim, C., Nghia, P. P., Kojima, M., Kato, Y., Forchino, F., Herman, P., Kruger, J. A. P., Saleh, M., Pascual, F., Dalla Valle, B., Lopez-Lopez, V., Casellas-Robert, M., Giustizieri, U., Citterio, D., Mishima, K., Fretland, A. A., Ghotbi, J., Ettorre, G. M., Colasanti, M., Guzman, Y., Ardito, F., Vani, S., Wang, H. -P., Choi, Sung Hoon, Chen, Kuo-Hsin, Syn, Nicholas L, Cipriani, Federica, Cheung, Tan-To, Chiow, Adrian K H, Choi, Gi-Hong, Siow, Tiing-Foong, Sucandy, Iswanto, Marino, Marco V, Gastaca, Mikel, Chong, Charing C, Lee, Jae Hoon, Ivanecz, Arpad, Mazzaferro, Vincenzo, Lopez-Ben, Santiago, Fondevila, Constantino, Rotellar, Fernando, Campos, Ricardo Roble, Efanov, Mikhail, Kingham, T Peter, Sutcliffe, Robert P, Troisi, Roberto I, Pratschke, Johann, Wang, Xiaoying, D'Hondt, Mathieu, Yong, Chee Chien, Levi Sandri, Giovanni Battista, Tang, Chung Ngai, Ruzzenente, Andrea, Cherqui, Daniel, Ferrero, Alessandro, Wakabayashi, Go, Scatton, Olivier, Aghayan, Davit, Edwin, Bjørn, Coelho, Fabricio Ferreira, Giuliante, Felice, Liu, Rong, Sijberden, Jasper, Abu Hilal, Mohammad, Sugioka, Atsushi, Long, Tran Cong Duy, Fuks, David, Aldrighetti, Luca, Han, Ho-Seong, and Goh, Brian K P

Subjects
Carcinoma, Hepatocellular, Laparoscopic liver, Settore MED/18 - CHIRURGIA GENERALE, Operative Time, Liver Neoplasms, Carcinoma, Hepatocellular, Difficulty score, Length of Stay, Iwate, Laparoscopic hepatectomy, Right posterior sectionectomy, Treatment Outcome, Postoperative Complications, Humans, Hepatectomy, Surgery, Laparoscopy, Retrospective Studies
Abstract

Introduction: The Iwate Score (IS) have not been well-validated for specific procedures, especially for right posterior sectionectomy (RPS). In this study, the utility of the IS was determined for laparoscopic (L)RPS and the effect of tumor location on surgical outcomes was investigated. Methods: Post-hoc analysis of 647 L-RPS performed in 40 international centers of which 596L-RPS cases met the inclusion criteria. Baseline characteristics and perioperative outcomes of patients stratified based on the Iwate score were compared to determine whether a correlation with surgical difficulty existed. A 1:1 Mahalanobis distance matching was utilized to investigate the effect of tumor location on L-RPS outcomes. Results: The patients were stratified into 3 levels of difficulty (31 intermediate, 143 advanced, and 422 expert) based on the IS. When using a stepwise increase of the IS excluding the tumor location score, only Pringle’s maneuver was more frequently used in the higher surgical difficulty level (35.5%, 54.6%, and 65.2%, intermediate, advanced, and expert levels, respectively, Z = 3.34, p = 0.001). Other perioperative results were not associated with a statistical gradation toward higher difficulty level. 80 of 85 patients with a segment VI lesion and 511 patients with a segment VII lesion were matched 1:1. There were no significant differences in the perioperative outcomes of the two groups including open conversion, operating time, blood loss, intraoperative blood transfusion, postoperative stay, major morbidity, and mortality. Conclusion: Among patients undergoing L-RPS, the IS did not significantly correlate with most outcome measures associated with intraoperative difficulty and postoperative outcomes. Similarly, tumor location had no effect on L-RPS outcomes.

Published
2022

34. Comparison between the difficulty of laparoscopic limited liver resections of tumors located in segment 7 versus segment 8

Author

Efanov, M., Salimgereeva, D., Alikhanov, R., A. G. R., Wu, Geller, D., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., Belli, A., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Fondevila, C., Rotellar, F., Choi, G. -H., Robless Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Herman, P., Di Benedetto, F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Levi Sandri, G. B., Cherqui, D., Scatton, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Han, H. -S., Abu Hilal, M., Soubrane, O., Fuks, D., Aldrighetti, L., Edwin, B., Goh, B. K. P., Chan, C. -Y., Syn, N., D'Silva, M., Lee, B., Lim, C., Nghia, P. P., Gastaca, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Lee, L. S., Jang, J. Y., Kojima, M., Kato, Y., Ghotbi, J., Kruger, J. A. P., Coelho, F. F., Lopez-Lopez, V., Valle, B. D., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Wang, H. -P., Pascual, F., Saleh, M., Kadam, P., Tang, C. -N., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Dogeas, E., Magistri, P., Mazzotta, A., Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, Efanov, M., Salimgereeva, D., Alikhanov, R., Wu, A. G. R., Geller, D., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., Belli, A., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Prieto, M., Vivarelli, M., Giuliante, F., Ruzzenente, A., Yong, C. -C., Fondevila, C., Rotellar, F., Choi, G. -H., Robless Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Herman, P., Di Benedetto, F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Levi Sandri, G. B., Cherqui, D., Scatton, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Han, H. -S., Abu Hilal, M., Soubrane, O., Fuks, D., Aldrighetti, L., Edwin, B., Goh, B. K. P., Chan, C. -Y., Syn, N., D'Silva, M., Lee, B., Lim, C., Nghia, P. P., Gastaca, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Lee, L. S., Jang, J. Y., Kojima, M., Kato, Y., Ghotbi, J., Kruger, J. A. P., Coelho, F. F., Lopez-Lopez, V., Valle, B. D., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Wang, H. -P., Pascual, F., Saleh, M., Kadam, P., Tang, C. -N., Ardito, F., Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Dogeas, E., Magistri, P., Mazzotta, A., Efanov, Mikhail, Salimgereeva, Diana, Alikhanov, Ruslan, Wu, Andrew G R, Geller, David, Cipriani, Federica, Aghayan, Davit L, Fretland, Asmund Avdem, Sijberden, Jasper, Belli, Andrea, Marino, Marco V, Mazzaferro, Vincenzo, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Prieto, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Fondevila, Constantino, Rotellar, Fernando, Choi, Gi-Hong, Robless Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P, Pratschke, Johann, Lai, Eric, Chong, Charing C, D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Herman, Paulo, Di Benedetto, Fabrizio, Kingham, T Peter, Liu, Rong, Long, Tran Cong Duy, Ferrero, Alessandro, Levi Sandri, Giovanni Battista, Cherqui, Daniel, Scatton, Olivier, Wakabayashi, Go, Troisi, Roberto I, Cheung, Tan-To, Sugioka, Atsushi, Han, Ho-Seong, Abu Hilal, Mohammad, Soubrane, Olivier, Fuks, David, Aldrighetti, Luca, Edwin, Bjorn, and Goh, Brian K P

Subjects
hepatectomy, laparoscopy, liver resection, posterosuperior segments, risk score, Hepatology, Settore MED/18 - CHIRURGIA GENERALE, Surgery, posterosuperior segment
Abstract

Background: Presently, according to different difficulty scoring systems, there is no difference in complexity estimation of laparoscopic liver resection (LLR) of segments 7 and 8. However, there is no published data supporting this assumption. To date, no studies have compared the outcomes of laparoscopic parenchyma-sparing resection of the liver segments 7 and 8. Methods: A post hoc analysis of patients undergoing LLR of segments 7 and 8 in 46 centers between 2004 and 2020 was performed. 1:1 Propensity score matching (PSM) was used to compare isolated LLR of segments 7 and 8. Subset analyses were also performed to compare atypical resections and segmentectomies of 7 and 8. Results: A total of 2411 patients were identified, and 1691 patients met the inclusion criteria. Comparison after PSM between the entire cohort of segment 7 and segment 8 resections revealed inferior results for segment 7 resection in terms of increased blood loss, blood transfusions, and conversions to open surgery. Subset analyses of only atypical resections similarly demonstrated poorer outcomes for segment 7 in terms of increased blood loss, operation time, blood transfusions, and conversions to open surgery. Conversely, a subgroup analysis of segmentectomies after PSM found better outcomes for segment 7 in terms of a shorter operation time and hospital stay. Conclusion: Differences in the outcomes of segments 7 and 8 resections suggest a greater difficulty of laparoscopic atypical resection of segment 7 compared to segment 8, and greater difficulty of segmentectomy 8 compared to segmentectomy 7.

Published
2022
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36. Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

Author

Goh, B. K. P., Han, H. -S., Chen, K. -H., Chua, D. W., Chan, C. -Y., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., D'Silva, M., Siow, T. F., Kato, Y., Lim, C., Nghia, P. P., Herman, P., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., Gastaca, M., Vivarelli, M., Giuliante, Felice, Ruzzenente, A., Yong, C. -C., Yin, M., Chen, Z., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Campos, R. R., Wang, X., Sutcliffe, R. P., Pratschke, J., Lai, E., Chong, C. C., D'Hondt, M., Monden, K., Lopez-Ben, S., Coelho, F. F., Kingham, T. P., Liu, R., Long, T. C. D., Ferrero, A., Sandri, G. B. L., Saleh, M., Cherqui, D., Scatton, O., Soubrane, O., Wakabayashi, G., Troisi, R. I., Cheung, T. -T., Sugioka, A., Hilal, M. A., Fuks, D., Edwin, B., Aldrighetti, L., Syn, N., Prieto, M., Schotte, H., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Kojima, M., Ghotbi, J., Kruger, J. A. P., Lopez-Lopez, V., Valle, B. D., Casellas I Robert, M., Mishima, K., Montalti, R., Giglio, M., Mazzotta, A., Lee, B., Wang, H. -P., Pascual, F., Kadam, P., Tang, C. -N., Yu, S., Ardito, Francesco, Vani, S., Giustizieri, U., Citterio, D., Mocchegiani, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Goh, Brian K P, Han, Ho-Seong, Chen, Kuo-Hsin, Chua, Darren W, Chan, Chung-Yip, Cipriani, Federica, Aghayan, Davit L, Fretland, Asmund A, Sijberden, Jasper, D'Silva, Mizelle, Siow, Tiing Foong, Kato, Yutaro, Lim, Chetana, Nghia, Phan Phuoc, Herman, Paulo, Marino, Marco V, Mazzaferro, Vincenzo, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Yin, Mengqui, Chen, Zewei, Fondevila, Constantino, Efanov, Mikhail, Rotellar, Fernando, Choi, Gi-Hong, Campos, Ricardo R, Wang, Xiaoying, Sutcliffe, Robert P, Pratschke, Johann, Lai, Eric, Chong, Charing C, D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Coelho, Fabricio F, Kingham, Thomas Peter, Liu, Rong, Long, Tran Cong Duy, Ferrero, Alessandro, Sandri, Giovanni B Levi, Saleh, Mansour, Cherqui, Daniel, Scatton, Olivier, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I, Cheung, Tan-To, Sugioka, Atsushi, Hilal, Mohammad Abu, Fuks, David, Edwin, Bjørn, and Aldrighetti, Luca

Subjects
benchmark, hepatectomy, quality assessment, Settore MED/18 - CHIRURGIA GENERALE, minimally invasive, Surgery, laparoscopic liver resection, global
Abstract

To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR).There is limited published data to date on the best achievable outcomes after L-LR.This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs.There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively.This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the "best achievable" results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.

Published
2022

39. Pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head with venous resection

Author

Flis Vojko, Potrc Stojan, Kobilica Nina, and Ivanecz Arpad

Subjects
pancreaticoduodenectomy, pancreatic cancer, vein resection, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Recent reports have shown that patients with vascular tumour invasion who undergo concurrent vascular resection can achieve long-term survival rates equivalent to those without vascular involvement requiring pancreaticoduodenectomy alone. There is no consensus about which patients benefit from the portal-superior mesenteric vein resection and there is no consensus about the best surgical technique of vessel reconstruction (resection with or without graft reconstruction). As published series are small the aim of this study was to evaluate our experience in pancreatectomies with en bloc vascular resection and reconstruction of vessels.

Published
2016
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40. Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases

Author

Liu, Qu, Zhang, Wanguang, Zhao, Joseph J, Syn, Nicholas L, Cipriani, Federica, Alzoubi, Mohammad, Aghayan, Davit L, Siow, Tiing-Foong, Lim, Chetana, Scatton, Olivier, Herman, Paulo, Coelho, Fabricio Ferreira, Marino, Marco V, Mazzaferro, Vincenzo, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung-Hoon, Lee, Jae Hoon, Prieto, Mikel, Vivarelli, Marco, Giuliante, Felice, Valle, Bernardo Dalla, Ruzzenente, Andrea, Yong, Chee-Chien, Chen, Zewei, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Valle, Raffaele Dalla, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O, Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P, Schmelzle, Moritz, Pratschke, Johann, Tang, Chung-Ngai, Chong, Charing C N, Lee, Kit-Fai, Meurs, Juul, D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, T Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Sandri, Giovanni Battista Levi, Saleh, Mansour, Cherqui, Daniel, Zheng, Junhao, Liang, Xiao, Mazzotta, Alessandro, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I, Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, D'Silva, Mizelle, Han, Ho-Seong, Nghia, Phan Phuoc, Long, Tran Cong Duy, Edwin, Bjørn, Fuks, David, Chen, Kuo-Hsin, Hilal, Mohammad Abu, Aldrighetti, Luca, Liu, Rong, and Goh, Brian K P

Published
2023

41. Impact of liver cirrhosis, the severity of cirrhosis, and portal hypertension on the outcomes of minimally invasive left lateral sectionectomies for primary liver malignancies

Author

Coelho, Fabricio Ferreira, Herman, Paulo, Kruger, Jaime A P, Andrew G R, Wu, Chin, Ken-Min, Hasegawa, Kiyoshi, Zhang, Wanguang, Alzoubi, Mohammed, Aghayan, Davit L, Siow, Tiing-Foong, Scatton, Olivier, Kingham, T Peter, Marino, Marco V, Mazzaferro, Vincenzo, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Dokmak, Safi, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Valle, Raffaele Dalla, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O, Rotellar, Fernando, Choi, Gi Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P, Pratschke, Johann, Lai, Eric C H, Chong, Charing C N, D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Liu, Rong, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cipriani, Federica, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I, Yin, Mengqiu, Cheung, Tan-To, Sugioka, Atsushi, Han, Ho-Seong, Long, Tran Cong Duy, Fuks, David, Abu Hilal, Mohammad, Chen, Kuo-Hsin, Aldrighetti, Luca, Edwin, Bjørn, and Goh, Brian K P

Published
2023

42. Impact of body mass index on the difficulty and outcomes of laparoscopic left lateral sectionectomy

Author

Zewei Chen, Mengqiu Yin, Junhao Fu, Shian Yu, Nicholas L. Syn, Darren W. Chua, T. Peter Kingham, Wanguang Zhang, Tijs J. Hoogteijling, Davit L. Aghayan, Tiing Foong Siow, Olivier Scatton, Paulo Herman, Marco V. Marino, Vincenzo Mazzaferro, Adrian K.H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Safi Dokmak, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Salvatore Gruttadauria, Alejandro Mejia, James O. Park, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric C.H. Lai, Charing C.N. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Qu Liu, Rong Liu, Alessandro Ferrero, Giuseppe Maria Ettorre, Federica Cipriani, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Yutaro Kato, Atsushi Sugioka, Ho-Seong Han, Tran Cong duy Long, David Fuks, Mohammad Abu Hilal, Luca Aldrighetti, Kuo-Hsin Chen, Bjørn Edwin, Brian K.P. Goh, Mikel Gastaca, Juul Meurs, Celine De Meyere, Kit-Fai Lee, Kelvin K. Ng, Diana Salimgereeva, Ruslan Alikhanov, Lip-Seng Lee, Jae-Young Jang, Masayuki Kojima, Jaime Arthur Pirola Kruger, Fabricio Ferreira Coelho, Victor Lopez-Lopez, Margarida Casellas I Robert, Roberto Montalti, Mariano Giglio, Mizelle D'Silva, Boram Lee, Hao-Ping Wang, Franco Pascual, Mansour Saleh, Simone Vani, Francesco Ardito, Ugo Giustizieri, Davide Citterio, Federico Mocchegiani, Giammauro Berardi, Marco Colasanti, Yoelimar Guzmán, Kevin P. Labadie, Maria Conticchio, Epameinondas Dogeas, Emanuele F. Kauffmann, Mario Giuffrida, Daniele Sommacale, Alexis Laurent, Paolo Magistri, Kohei Mishima, Moritz Schmelzle, Felix Krenzien, Prashant Kadam, Jacob Ghotbi, Åsmund Avdem Fretland, Fabio Forchino, Alessandro Mazzotta, Francois Cauchy, Chetana Lim, Bernardo Dalla Valle, Junhao Zheng, Phan Phuoc Nghia, and Graduate School

Subjects
Minimally-invasive liver, Oncology, Left lateral sectionectomy, Laparoscopic hepatectomy, Laparoscopic liver, Minimally-invasive hepatectomy, Surgery, General Medicine, Body mass index
Abstract

Introduction: Currently, the impact of body mass index (BMI) on the outcomes of laparoscopic liver resections (LLR) is poorly defined. This study attempts to evaluate the impact of BMI on the peri-operative outcomes following laparoscopic left lateral sectionectomy (L-LLS). Methods: A retrospective analysis of 2183 patients who underwent pure L-LLS at 59 international centers between 2004 and 2021 was performed. Associations between BMI and selected peri-operative outcomes were analyzed using restricted cubic splines. Results: A BMI of >27kg/m2 was associated with increased in blood loss (Mean difference (MD) 21 mls, 95% CI 5–36), open conversions (Relative risk (RR) 1.13, 95% CI 1.03–1.25), operative time (MD 11 min, 95% CI 6–16), use of Pringles maneuver (RR 1.15, 95% CI 1.06–1.26) and reductions in length of stay (MD -0.2 days, 95% CI -0.3 to −0.1). The magnitude of these differences increased with each unit increase in BMI. However, there was a “U” shaped association between BMI and morbidity with the highest complication rates observed in underweight and obese patients. Conclusion: Increasing BMI resulted in increasing difficulty of L-LLS. Consideration should be given to its incorporation in future difficulty scoring systems in laparoscopic liver resections.

Published
2023

43. Impact of body mass index on perioperative outcomes of laparoscopic major hepatectomies

Author

Berardi, Giammauro, Kingham, T Peter, Zhang, Wanguang, Syn, Nicholas L, Koh, Ye-Xin, Jaber, Bashar, Aghayan, Davit L, Siow, Tiing Foong, Lim, Chetana, Scatton, Olivier, Herman, Paulo, Coelho, Fabricio Ferreira, Marino, Marco V, Mazzaferro, Vincenzo, Chiow, Adrian K H, Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Dalla Valle, Bernardo, Ruzzenente, Andrea, Yong, Chee-Chien, Chen, Zewei, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O, Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P, Schmelzle, Moritz, Pratschke, Johann, Lai, Eric C H, Chong, Charing C N, Meurs, Juul, D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Liu, Qu, Liu, Rong, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cipriani, Federica, Pascual, Franco, Cherqui, Daniel, Zheng, Junhao, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I, Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, D'Silva, Mizelle, Han, Ho-Seong, Nghia, Phan Phuoc, Long, Tran Cong Duy, Edwin, Bjørn, Fuks, David, Abu Hilal, Mohammad, Aldrighetti, Luca, Chen, Kuo-Hsin, and Goh, Brian K P

Published
2023

45. The learning curve of laparoscopic liver resection utilising a difficulty score

Author

Irena Plahuta, Stojan Potrč, Arpad Ivanecz, Tomislav Magdalenić, Iztok Peruš, Matej Mencinger, and Spela Turk

Subjects
Retrospective review, business.industry, Liver Neoplasms, Liver resections, Single surgeon, Outcome (probability), Resection, Oncology, Blood loss, Learning curve, Statistics, Hepatectomy, Humans, Medicine, Laparoscopy, Radiology, Nuclear Medicine and imaging, business, Learning Curve, Regression curve
Abstract

Background This study aimed to quantitatively evaluate the learning curve of laparoscopic liver resection (LLR) of a single surgeon. Patients and methods A retrospective review of a prospectively maintained database of liver resections was conducted. 171 patients undergoing pure LLRs between April 2008 and April 2021 were analysed. The Halls difficulty score (HDS) for theoretical predictions of intraoperative complications (IOC) during LLR was applied. IOC was defined as blood loss over 775 mL, unintentional damage to the surrounding structures, and conversion to an open approach. Theoretical association between HDS and the predicted probability of IOC was utilised to objectify the shape of the learning curve. Results The obtained learning curve has resulted from thirteen years of surgical effort of a single surgeon. It consists of an absolute and a relative part in the mathematical description of the additive function described by the logarithmic function (absolute complexity) and fifth-degree regression curve (relative complexity). The obtained learning curve determines the functional dependency of the learning outcome versus time and indicates several local extreme values (peaks and valleys) in the learning process until proficiency is achieved. Conclusions This learning curve indicates an ongoing learning process for LLR. The proposed mathematical model can be applied for any surgical procedure with an existing difficulty score and a known theoretically predicted association between the difficulty score and given outcome (for example, IOC).

Published
2021
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47. Laparoscopic liver resection for colorectal metastases – treatment results

Author

Arpad Ivanecz, Vid Pivec, Irena Plahuta, Bojan Krebs, Tomaž Jagrič, and Stojan Potrč

Subjects
laparoscopic liver resection, colorectal liver metastases, morbidity, mortality, survival analysis, Medicine
Abstract

Background: In many referral centers, laparoscopic liver resection (LLR) is a well-established method for the management of colorectal liver metastases (CLM). The aim of this study is to review a single institution experience.Methods: Between April 2008 and September 2016, 58 patients underwent LLR for various benign and malignant liver tumors. The analysis included 12 patients operated on for CLM. The primary outcomes of this prospective non-randomized study included operative procedure and operating time (minutes), estimated blood loss (mL), conversion rate, R0 resections, resection margins (mm), length of hospital stay (days), post-operative morbidity, and mortality. The secondary outcome of the study was survival analysis.Results: Eight patients (67 %) had atypical LLR. The average operating time was 130 minutes (range 60–210 minutes). The mean estimated blood loss was 140 mL (range < 50–600 mL). In one patient LLR was converted to open procedure (conversion rate 8 %). Seven patients (58 %) had one liver metastasis. The mean metastasis size was 3.6 cm (range 1–9 cm). R0 resection was achieved in all cases. The mean resection margin was 6.8 mm (range 2–15 mm). Te mean length of hospital stay was 6 days (range 3–12 days). Morbidity and mortality rates were 0 %. The median follow-up for surviving patients was 13 months. Nine patients are alive with no evidence of disease, two patients are alive with disease and one patient died of disease.Conclusion: LLR is a feasible and safe method for the treatment of CLM and there is no compromise of oncological surgical principles.

Published
2017

48. Hepatocelični rak - možnost resekcije jeter

Author

Arpad Ivanecz, Marko Sremec, Tomaž Jagrič, and Stojan Potrč

Subjects
jetra, hepatocelični rak, resekcija, kirurški postopki, operativni, zapleti, smrtnost, preživetje, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Resekcija jeter (RJ) je ostala glavna oblika terapije pri solitarnem hepatoceličnem raku (HCC), pri bolnikih z ohranjeno funkcijsko rezervo jeter in v primernem splošnem stanju. Izpopolnjene slikovne preiskave so pripomogle k boljši izbiri bolnikov. Kirurgija jeter je napredovala: uporabne so številne tehnike transekcije jetrnega tkiva; dosegljive so različne naprave, ki omogočajo hitrejše in natančnejše operiranje v brezkrvnem operativnem polju. Izboljšana kirurška tehnika, vzdrževanje nizkega centralnega venskega pritiska in napredek pri negi bolnika po operaciji so omogočili, da se je smrtnost po operaciji jeter v izbranih serijah znižala celo do 0%. Barcelona Clinic Liver Cancer (BCLC) klasifikacija poleg zamejitve bolezni, nudi priporočila tudi glede izbora terapije. Kirurško terapijo omejuje zgolj na bolnike z zgodnjim stadijem raka. Namen tega prispevka je raziskati, ali je v sedanjem času mogoče RJ opraviti s sprejemljivimi kratko- in dolgoročnimi rezultati tudi pri bolnikih s takšnim HCC, pri katerem so prisotni številni in veliki tumorji, ki makroskopsko vdirajo v žile.

Published
2014

49. Utility of the Iwate difficulty scoring system for laparoscopic right posterior sectionectomy: do surgical outcomes differ for tumors in segments VI and VII?

Author

Choi, S. H., Chen, K. -H., Syn, N. L., Cipriani, F., Cheung, T. -T., Chiow, A. K. H., Choi, G. -H., Siow, T. -F., Sucandy, I., Marino, M. V., Gastaca, M., Chong, C. C., Lee, J. H., Ivanecz, A., Mazzaferro, V., Lopez-Ben, S., Fondevila, C., Rotellar, F., Campos, R. R., Efanov, M., Kingham, T. P., Sutcliffe, R. P., Troisi, R. I., Pratschke, J., Wang, X., D'Hondt, M., Yong, C. C., Levi Sandri, G. B., Tang, C. N., Ruzzenente, A., Cherqui, D., Ferrero, A., Wakabayashi, G., Scatton, O., Aghayan, D., Edwin, B., Coelho, F. F., Giuliante, Felice, Liu, R., Sijberden, J., Abu Hilal, M., Sugioka, A., Long, T. C. D., Fuks, D., Aldrighetti, L., Han, H. -S., Goh, B. K. P., Kang, I., Jang, J. Y., Chan, C. -Y., D'Silva, M., Schotte, H., De Meyere, C., Lai, E., Krenzien, F., Schmelzle, M., Kadam, P., Montalti, R., Giglio, M., Liu, Q., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Prieto, M., Lim, C., Nghia, P. P., Kojima, M., Kato, Y., Forchino, F., Herman, P., Kruger, J. A. P., Saleh, M., Pascual, F., Dalla Valle, B., Lopez-Lopez, V., Casellas-Robert, M., Giustizieri, U., Citterio, D., Mishima, K., Fretland, A. A., Ghotbi, J., Ettorre, G. M., Colasanti, M., Guzman, Y., Ardito, Francesco, Vani, S., Wang, H. -P., Giuliante F. (ORCID:0000-0001-9517-8220), Ardito F. (ORCID:0000-0003-1596-2862), Choi, S. H., Chen, K. -H., Syn, N. L., Cipriani, F., Cheung, T. -T., Chiow, A. K. H., Choi, G. -H., Siow, T. -F., Sucandy, I., Marino, M. V., Gastaca, M., Chong, C. C., Lee, J. H., Ivanecz, A., Mazzaferro, V., Lopez-Ben, S., Fondevila, C., Rotellar, F., Campos, R. R., Efanov, M., Kingham, T. P., Sutcliffe, R. P., Troisi, R. I., Pratschke, J., Wang, X., D'Hondt, M., Yong, C. C., Levi Sandri, G. B., Tang, C. N., Ruzzenente, A., Cherqui, D., Ferrero, A., Wakabayashi, G., Scatton, O., Aghayan, D., Edwin, B., Coelho, F. F., Giuliante, Felice, Liu, R., Sijberden, J., Abu Hilal, M., Sugioka, A., Long, T. C. D., Fuks, D., Aldrighetti, L., Han, H. -S., Goh, B. K. P., Kang, I., Jang, J. Y., Chan, C. -Y., D'Silva, M., Schotte, H., De Meyere, C., Lai, E., Krenzien, F., Schmelzle, M., Kadam, P., Montalti, R., Giglio, M., Liu, Q., Lee, K. -F., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Prieto, M., Lim, C., Nghia, P. P., Kojima, M., Kato, Y., Forchino, F., Herman, P., Kruger, J. A. P., Saleh, M., Pascual, F., Dalla Valle, B., Lopez-Lopez, V., Casellas-Robert, M., Giustizieri, U., Citterio, D., Mishima, K., Fretland, A. A., Ghotbi, J., Ettorre, G. M., Colasanti, M., Guzman, Y., Ardito, Francesco, Vani, S., Wang, H. -P., Giuliante F. (ORCID:0000-0001-9517-8220), and Ardito F. (ORCID:0000-0003-1596-2862)

Abstract

Introduction: The Iwate Score (IS) have not been well-validated for specific procedures, especially for right posterior sectionectomy (RPS). In this study, the utility of the IS was determined for laparoscopic (L)RPS and the effect of tumor location on surgical outcomes was investigated. Methods: Post-hoc analysis of 647 L-RPS performed in 40 international centers of which 596L-RPS cases met the inclusion criteria. Baseline characteristics and perioperative outcomes of patients stratified based on the Iwate score were compared to determine whether a correlation with surgical difficulty existed. A 1:1 Mahalanobis distance matching was utilized to investigate the effect of tumor location on L-RPS outcomes. Results: The patients were stratified into 3 levels of difficulty (31 intermediate, 143 advanced, and 422 expert) based on the IS. When using a stepwise increase of the IS excluding the tumor location score, only Pringle’s maneuver was more frequently used in the higher surgical difficulty level (35.5%, 54.6%, and 65.2%, intermediate, advanced, and expert levels, respectively, Z = 3.34, p = 0.001). Other perioperative results were not associated with a statistical gradation toward higher difficulty level. 80 of 85 patients with a segment VI lesion and 511 patients with a segment VII lesion were matched 1:1. There were no significant differences in the perioperative outcomes of the two groups including open conversion, operating time, blood loss, intraoperative blood transfusion, postoperative stay, major morbidity, and mortality. Conclusion: Among patients undergoing L-RPS, the IS did not significantly correlate with most outcome measures associated with intraoperative difficulty and postoperative outcomes. Similarly, tumor location had no effect on L-RPS outcomes.

Published
2022

50. Impact of tumor size on the difficulty of laparoscopic left lateral sectionectomies

Author

Arizza, G., Russolillo, N., Ferrero, A., Syn, N. L., Cipriani, F., Aghayan, D., Marino, M. V., Memeo, R., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Vivarelli, M., Di Benedetto, F., Choi, S. -H., Lee, J. H., Park, J. O., Gastaca, M., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Robles-Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Tang, C. N., Chong, C. C., D'Hondt, M., Yong, C. C., Ruzzenente, A., Herman, P., Kingham, T. P., Scatton, O., Liu, R., Levi Sandri, G. B., Soubrane, O., Mejia, A., Lopez-Ben, S., Monden, K., Wakabayashi, G., Cherqui, D., Troisi, R. I., Yin, M., Giuliante, Felice, Geller, D., Sugioka, A., Edwin, B., Cheung, T. -T., Long, T. C. D., Hilal, M. A., Fuks, D., Chen, K. -H., Aldrighetti, L., Han, H. -S., Goh, B. K. P., Chan, C. -Y., Prieto, M., Meurs, J., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Ng, K. K., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Labadie, K. P., Kato, Y., Kojima, M., Fretland, A. A., Ghotbi, J., Coelho, F. F., Kruger, J. A. P., Lopez-Lopez, V., Magistri, P., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Mazzotta, A., Lee, B., D'Silva, M., Wang, H. -P., Saleh, M., Pascual, F., Suhool, A., Nghia, P. P., Lim, C., Liu, Q., Kadam, P., Dalla Valle, B., Lai, E. C., Conticchio, M., Giustizieri, U., Citterio, D., Chen, Z., Yu, S., Ardito, Francesco, Vani, S., Dogeas, E., Siow, T. F., Mocchegianni, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Giuliante F. (ORCID:0000-0001-9517-8220), Ardito F. (ORCID:0000-0003-1596-2862), Arizza, G., Russolillo, N., Ferrero, A., Syn, N. L., Cipriani, F., Aghayan, D., Marino, M. V., Memeo, R., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Vivarelli, M., Di Benedetto, F., Choi, S. -H., Lee, J. H., Park, J. O., Gastaca, M., Fondevila, C., Efanov, M., Rotellar, F., Choi, G. -H., Robles-Campos, R., Wang, X., Sutcliffe, R. P., Pratschke, J., Tang, C. N., Chong, C. C., D'Hondt, M., Yong, C. C., Ruzzenente, A., Herman, P., Kingham, T. P., Scatton, O., Liu, R., Levi Sandri, G. B., Soubrane, O., Mejia, A., Lopez-Ben, S., Monden, K., Wakabayashi, G., Cherqui, D., Troisi, R. I., Yin, M., Giuliante, Felice, Geller, D., Sugioka, A., Edwin, B., Cheung, T. -T., Long, T. C. D., Hilal, M. A., Fuks, D., Chen, K. -H., Aldrighetti, L., Han, H. -S., Goh, B. K. P., Chan, C. -Y., Prieto, M., Meurs, J., De Meyere, C., Krenzien, F., Schmelzle, M., Lee, K. -F., Ng, K. K., Salimgereeva, D., Alikhanov, R., Lee, L. -S., Jang, J. Y., Labadie, K. P., Kato, Y., Kojima, M., Fretland, A. A., Ghotbi, J., Coelho, F. F., Kruger, J. A. P., Lopez-Lopez, V., Magistri, P., Robert, M. C. I., Mishima, K., Montalti, R., Giglio, M., Mazzotta, A., Lee, B., D'Silva, M., Wang, H. -P., Saleh, M., Pascual, F., Suhool, A., Nghia, P. P., Lim, C., Liu, Q., Kadam, P., Dalla Valle, B., Lai, E. C., Conticchio, M., Giustizieri, U., Citterio, D., Chen, Z., Yu, S., Ardito, Francesco, Vani, S., Dogeas, E., Siow, T. F., Mocchegianni, F., Ettorre, G. M., Colasanti, M., Guzman, Y., Giuliante F. (ORCID:0000-0001-9517-8220), and Ardito F. (ORCID:0000-0003-1596-2862)

Abstract

Background: Tumor size (TS) represents a critical parameter in the risk assessment of laparoscopic liver resections (LLR). Moreover, TS has been rarely related to the extent of liver resection. The aim of this study was to study the relationship between tumor size and difficulty of laparoscopic left lateral sectionectomy (L-LLS). Methods: The impact of TS cutoffs was investigated by stratifying tumor size at each 10 mm-interval. The optimal cutoffs were chosen taking into consideration the number of endpoints which show a statistically significant split around the cut-points of interest and the magnitude of relative risk after correction for multiple risk factors. Results: A total of 1910 L-LLS were included. Overall, open conversion and intraoperative blood transfusion were 3.1 and 3.3%, respectively. The major morbidity rate was 2.7% and 90-days mortality 0.6%. Three optimal TS cutoffs were identified: 40-, 70-, and 100-mm. All the selected cutoffs showed a significant discriminative power for the prediction of open conversion, operative time, blood transfusion and need of Pringle maneuver. Moreover, 70- and 100-mm cutoffs were both discriminative for estimated blood loss and major complications. A stepwise increase in rates of open conversion rate (Z = 3.90, P <.001), operative time (Z = 3.84, P <.001), blood loss (Z = 6.50, P <.001), intraoperative blood transfusion rate (Z = 5.15, P <.001), Pringle maneuver use (Z = 6.48, P <.001), major morbidity(Z = 2.17, P =.030) and 30-days readmission (Z = 1.99, P =.047) was registered as the size increased. Conclusion: L-LLS for tumors of increasing size was associated with poorer intraoperative and early postoperative outcomes suggesting increasing difficulty of the procedure. We determined three optimal TS cutoffs (40-, 70- and 100-mm) to accurately stratify surgical difficulty after L-LLS.

Published
2022

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