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3. Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly

Author

Niimi, Yoshiki, Janelidze, Shorena, Sato, Kenichiro, Tomita, Naoki, Tsukamoto, Tadashi, Kato, Takashi, Yoshiyama, Kenji, Kowa, Hisatomo, Iwata, Atsushi, Ihara, Ryoko, Suzuki, Kazushi, Kasuga, Kensaku, Ikeuchi, Takeshi, Ishii, Kenji, Ito, Kengo, Nakamura, Akinori, Senda, Michio, Day, Theresa A., Burnham, Samantha C., Iaccarino, Leonardo, Pontecorvo, Michael J., Hansson, Oskar, and Iwatsubo, Takeshi

Published
2024
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16. Clinical practice guidelines for high-resolution breast PET, 2019 edition

Author

Satoh, Yoko, Kawamoto, Masami, Kubota, Kazunori, Murakami, Koji, Hosono, Makoto, Senda, Michio, Sasaki, Masayuki, Momose, Toshimitsu, Ito, Kengo, Okamura, Terue, Oda, Keiichi, Kuge, Yuji, Sakurai, Minoru, Tateishi, Ukihide, Fujibayashi, Yasuhisa, Magata, Yasuhiro, Yoshida, Takeshi, Waki, Atsuo, Kato, Katsuhiko, Hashimoto, Teisuke, Uchiyama, Mayuki, Kinuya, Seigo, Higashi, Tatsuya, Magata, Yasuhiro, Machitori, Akihiro, Maruno, Hirotaka, Minamimoto, Ryogo, and Yoshinaga, Keiichiro

Published
2021
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17. Tracking Metabolite Variations during the Degradation of Vegetables in Rice Bran Bed with Intact-State Nuclear Magnetic Resonance Spectroscopy.

Author

Ito, Kengo, Yamamoto, Ryusei, and Sekiyama, Yasuyo

Subjects
LACTIC acid fermentation, NUCLEAR magnetic resonance spectroscopy, AMINO acid metabolism, NUCLEAR magnetic resonance, FERMENTED foods
Abstract

Fermentation—a process of compound degradation by microorganisms—is a traditional food processing method utilized worldwide for the long-term preservation of fresh foods. In recent years, fermented foods have gained attention as health foods. Fermentation increases the nutritional value of ingredients, producing complex flavors and aromas. To identify unknown components in fermented foods, it is necessary to analyze compounds and conditions nondestructively and comprehensively. We performed intact-state nuclear magnetic resonance (NMR) spectroscopy using intermolecular single quantum coherence (iSQC) to detect the degradation of vegetables directly and nondestructively. We used two types of vegetables and a rice bran bed (nukazuke), which is used for traditional vegetable fermentation in Japan. Major metabolites such as saccharides, organic acids, and amino acids were identified in iSQC-sliced spectra. Comparing NMR signal intensities during degradation revealed the transition of metabolites characteristic of lactic acid fermentation. A pathway-based network analysis showed pathways involved in amino acid metabolism and lactic acid fermentation. Our analytical approach with intact-state NMR spectroscopy using iSQC demonstrated that it may be effective in other experimental systems, allowing for the evaluation of phenomena that have been conventionally overlooked in their true state. [ABSTRACT FROM AUTHOR]

Published
2024
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19. VMAT with DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery: results of a non-inferiority clinical study

Author

Jingu, Keiichi, primary, Ito, Kengo, additional, Sato, Kiyokazu, additional, Umezawa, Rei, additional, Yamamoto, Takaya, additional, Takahashi, Noriyoshi, additional, Suzuki, Yu, additional, Kishida, Keita, additional, Omata, So, additional, Harada, Hinako, additional, Seki, Yasuhiro, additional, Chiba, Nanae, additional, and Kadoya, Noriyuki, additional

Published
2023
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21. Pre-treatment Evaluation of Patients Eligible for Whole Brain Radiation Therapy: The Risk of Hippocampal Metastases in a Retrospective Study of 248 Cases at a Single Institution

Author

Ishikawa, Yojiro, primary, Umezawa, Rei, additional, Yamamoto, Takaya, additional, Takahashi, Noriyoshi, additional, Takeda, Kazuya, additional, Suzuki, Yu, additional, Kishida, Keita, additional, Teramura, Satoshi, additional, Ito, Kengo, additional, and Jingu, Keiichi, additional

Published
2023
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29. VMAT with DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery: results of a non-inferiority clinical study.

Author

Jingu, Keiichi, Ito, Kengo, Sato, Kiyokazu, Umezawa, Rei, Yamamoto, Takaya, Takahashi, Noriyoshi, Suzuki, Yu, Kishida, Keita, Omata, So, Harada, Hinako, Seki, Yasuhiro, Chiba, Nanae, and Kadoya, Noriyuki

Subjects
BREAST, LUMPECTOMY, VOLUMETRIC-modulated arc therapy, BREAST cancer, RADIODERMATITIS, RADIOTHERAPY
Abstract

The purpose of this study was to show the safety of volumetric modulated arc therapy (VMAT) with deep inspiration breath-hold (DIBH) in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery in a clinical setting. Twenty-five Japanese women, aged 20–59 years, who were enrolled in this prospective non-inferiority study received VMAT under the condition of DIBH with 42.4 Gy/16 fractions for whole-breast irradiation (WBI) ± boost irradiation for the tumor bed to show the non-inferiority of VMAT with DIBH to conventional fractionated WBI with free breathing. The primary endpoint was the rate of occurrence of radiation dermatitis of Grade 3 or higher or pneumonitis of Grade 2 or higher within 6 months after the start of radiotherapy. This study was registered with UMIN00004321. All of the enrolled patients completed the planned radiotherapy without interruption. The evaluation of adverse events showed that three patients (12.0%) had Grade 2 radiation dermatitis. There was no other Grade 2 adverse event and there was no patient with an adverse event of Grade 3 or higher. Those results confirmed our hypothesis that the experimental treatment method is non-inferior compared with our historical results. There was no patient with locoregional recurrence or metastases. In conclusion, VMAT under the condition of DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery can be performed safely in a clinical setting. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls.

Author

Masuda, Hiroki, Mori, Masahiro, Hirano, Shigeki, Uzawa, Akiyuki, Uchida, Tomohiko, Muto, Mayumi, Ohtani, Ryohei, Aoki, Reiji, Hirano, Yoshiyuki, Iwatsubo, Takeshi, Asada, Takashi, Arai, Hiroyuki, Sugishita, Morihiro, Matsuda, Hiroshi, Ito, Kengo, Senda, Michio, Ishii, Kenji, Kuwano, Ryozo, Ikeuchi, Takeshi, and Sato, Noriko

Subjects
NEUROMYELITIS optica, AQUAPORINS, ATROPHY, CEREBRAL atrophy, MAGNETIC resonance imaging, WHITE matter (Nerve tissue)
Abstract

We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman's rho = − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman's rho = − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD. [ABSTRACT FROM AUTHOR]

Published
2023
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31. High performance plasma amyloid- biomarkers for Alzheimers disease

Author

Nakamura, Akinori, Kaneko, Naoki, Villemagne, Victor L., Kato, Takashi, Doecke, James, Dor, Vincent, Fowler, Chris, Li, Qiao-Xin, Martins, Ralph, Rowe, Christopher, Tomita, Taisuke, Matsuzaki, Katsumi, Ishii, Kenji, Ishii, Kazunari, Arahata, Yutaka, Iwamoto, Shinichi, Ito, Kengo, Tanaka, Koichi, Masters, Colin L., and Yanagisawa, Katsuhiko

Subjects
Glycoproteins -- Health aspects, Alzheimer's disease -- Physiological aspects, Biological markers -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Akinori Nakamura [1]; Naoki Kaneko [2]; Victor L. Villemagne [3, 4]; Takashi Kato [1, 5]; James Doecke [6]; Vincent Dor [3, 6]; Chris Fowler [4]; Qiao-Xin Li [4]; Ralph [...]

Published
2018
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35. Estimation of blood-based biomarkers of glial activation related to neuroinflammation

Author

Yasuno, Fumihiko, primary, Watanabe, Atsushi, additional, Kimura, Yasuyuki, additional, Yamauchi, Yumeka, additional, Ogata, Aya, additional, Ikenuma, Hiroshi, additional, Abe, Junichiro, additional, Minami, Hiroyuki, additional, Nihashi, Takashi, additional, Yokoi, Kastunori, additional, Hattori, Saori, additional, Shimoda, Nobuyoshi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Takeda, Akinori, additional, Sakurai, Takashi, additional, Ito, Kengo, additional, and Kato, Takashi, additional

Published
2022
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40. Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

Author

Hatano, Kentaro, Sekimata, Katsuhiko, Yamada, Takashi, Abe, Junichiro, Ito, Kengo, Ogawa, Mikako, Magata, Yasuhiro, Toyohara, Jun, Ishiwata, Kiichi, Biggio, Giovanni, Serra, Mariangela, Laquintana, Valentino, Denora, Nunzio, Latrofa, Andrea, Trapani, Giuseppe, Liso, Gaetano, Suzuki, Hiromi, Sawada, Makoto, Nomura, Masahiko, and Toyama, Hiroshi

Published
2015
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43. Clinical practice guideline for dedicated breast PET

Author

Hosono, Makoto, Saga, Tsuneo, Ito, Kengo, Kumita, Shinichiro, Sasaki, Masayuki, Senda, Michio, Hatazawa, Jun, Watanabe, Hiroshi, Ito, Hiroshi, Kanaya, Shinichi, Kimura, Yuichi, Saji, Hideo, Jinnouchi, Seishi, Fukukita, Hiroyoshi, Murakami, Koji, Kinuya, Seigo, Yamazaki, Junichi, Uchiyama, Mayuki, Uno, Koichi, Kato, Katsuhiko, Kawano, Tsuyoshi, Kubota, Kazuo, Togawa, Takashi, Honda, Norinari, Maruno, Hirotaka, Yoshimura, Mana, Kawamoto, Masami, and Ozawa, Yukihiko

Published
2014
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44. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study

Author

Ito, Kengo, Mori, Etsuro, Fukuyama, Hidenao, Ishii, Kazunari, Washimi, Yukihiko, Asada, Takashi, Mori, Satoru, Meguro, Kenichi, Kitamura, Shin, Hanyu, Haruo, Nakano, Seigo, Matsuda, Hiroshi, Kuwabara, Yasuo, Hashikawa, Kazuo, Momose, Toshimitsu, Uchida, Yoshitaka, Hatazawa, Jun, Minoshima, Satoshi, Kosaka, Kenji, Yamada, Tatsuo, Yonekura, Yoshiharu, and J-COSMIC Study Group

Published
2013
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47. Differentiation Between Dementia With Lewy Bodies And Alzheimer’s Disease Using Voxel-Based Morphometry Of Structural MRI:AMulticenter Study

Author

Matsuda, Hiroshi, Yokoyama, Kota, Sato, Noriko, Ito, Kengo, Nemoto, Kiyotaka, Oba, Hiroshi, Hanyu, Haruo, Kanetaka, Hidekazu, Mizumura, Sunao, Kitamura, Shin, Shinotoh, Hitoshi, Shimada, Hitoshi, Suhara, Tetsuya, Terada, Hitoshi, Nakatsuka, Tomoya, Kawakatsu, Shinobu, Hayashi, Hiroshi, Asada, Takashi, Ono, Tetsutaro, Goto, Tomoaki, Shigemori, Keiko, Hiroshi, Matsuda, Hitoshi, Shinoto, Hitoshi, Shimada, and Tetsuya, Suhara

Subjects
nervous system, mental disorders, behavioral disciplines and activities, nervous system diseases
Abstract

Dementia with Lewy bodies (DLB) is one of the main etiologies of neurodegenerative dementia after Alzheimer’s disease (AD).1 Distinguishing DLB from AD is difficult because of their overlapping clinical and pathological features.2–4 Patients with clinically defined DLB may also have AD-type pathological changes as well as the characteristic Lewy bodies. However, the differential diagnosis is particularly important because DLB respond better to cholinesterase inhibitors but are sensitive to neuroleptics, which cause worsening of clinical status.

Published
2019

48. Differentiation Between Dementia With Lewy Bodies And Alzheimer’s Disease Using Voxel-Based Morphometry Of Structural MRI: A Multicenter Study

Author

Matsuda, Hiroshi, Yokoyama, Kota, Sato, Noriko, Ito, Kengo, Nemoto, Kiyotaka, Oba, Hiroshi, Hanyu, Haruo, Kanetaka, Hidekazu, Mizumura, Sunao, Kitamura, Shin, Shinotoh, Hitoshi, Shimada, Hitoshi, Suhara, Tetsuya, Terada, Hitoshi, Nakatsuka, Tomoya, Kawakatsu, Shinobu, Hayashi, Hiroshi, Asada, Takashi, Ono, Tetsutaro, Goto, Tomoaki, and Shigemori, Keiko

Subjects
nervous system, mental disorders, voxel-based morphometry, dementia with Lewy bodies, Alzheimer’s disease, behavioral disciplines and activities, Original Research, MRI, nervous system diseases
Abstract

Background: The differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) is particularly important because DLB patients respond better to cholinesterase inhibitors but sometimes exhibit sensitivity to neuroleptics, which may cause worsening of clinical status. Antemortem voxel-based morphometry (VBM) using structural MRI has previously revealed that patients with DLB have normal hippocampal volume, but atrophy in the dorsal mesopontine area. Objectives: The aim of this multicenter study was to determine whether VBM of the brain stem in addition to that of medial temporal lobe structures improves the differential diagnosis of AD and DLB. Methods: We retrospectively chose 624 patients who were clinically diagnosed with either DLB (239 patients) or AD (385 patients) from 10 institutes using different MR scanners with different magnetic field strengths. In all cases, VBM was performed on 3D T1-weighted images. The degree of local atrophy was calculated using Z-score by comparison with a database of normal volumes of interest (VOIs) in medial temporal lobe (MTL) and the dorsal brain stem (DBS). The discrimination of DLB and AD was evaluated using Z-score values in these two VOIs. MRI data from 414 patients were used as the training data set to determine the classification criteria, with the MRI data from the remaining 210 patients used as the test data set. Results: The DLB and AD patients did not differ with respect to mean age or Mini-Mental State Examination scores. Z-index scores showed that there was significantly more atrophy in MTL of AD patients, compared to DLB patients and in DBS of DLB patients, compared to AD patients. The discrimination accuracies of VBM were 63.3% in the test data set and 73.4% in the training data set. Conclusion: VBM of DBS in addition to that of MTL improves the differentiation of DLB and AD.

Published
2019

50. IMRT improves local control in patients with nasopharyngeal carcinoma compared with conventional radiotherapy: propensity score-matched analysis

Author

Ma, Zichang, primary, Umezawa, Rei, additional, Yamamoto, Takaya, additional, Ishikawa, Yojiro, additional, Takahashi, Noriyoshi, additional, Takeda, Kazuya, additional, Suzuki, Yu, additional, Tang, Liuwei, additional, Ito, Kengo, additional, Kadoya, Noriyuki, additional, and Jingu, Keiichi, additional

Published
2021
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