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1. Osteocalcin and regulatory cytokine imbalance in children with congenital cleft lip and palate

Author

Irina Nesterova, Marina Mitropanova, Galina Chudilova, and Lyudmila Lomtatidze

Subjects
cytokine imbalance, osteocalcin, congenital cleft lip and palate, children, Immunologic diseases. Allergy, RC581-607
Abstract

The aim of the work was a comprehensive assessment of the cytokine system and peripheral blood osteocalcin with the establishment of features of their interconnections in children with congenital cleft lip and palate (CCLP) in comparison with corresponding controls at different age periods. Levels of IL17, IL4, IL6, IL1β, IFNγ and osteocalcin were analyzed by enzyme immunoassay in the peripheral blood of 80 children (0–12 months, 1–3 years, 4–9 years, 10–15 years) with CCLP and age-appropriate control of healthy individuals (40 people). An analysis of the obtained data shows that in children with CCLP we revealed significant differences between pro-inflammatory (IL1β, IL6, IL17), regulatory (IFNγ), anti-inflammatory (IL4) cytokines and osteocalcin compared with controls. Differences were found in the content of IL17, IFNγ, IL4 and osteocalcin in healthy children and in children with CCLP in postnatal ontogenesis. Cytokine deregulation of immunosteogenesis in CCLP, leading to a significant deficit of osteocalcin in the first year of life due to imbalance of the cytokine profile: discordant IL17, IFNγ and IL4 were detected. Obtained data are undoubtedly important in the future for developing new strategies for targeted therapy aimed at normalizing osteocalcin levels at different age periods in children with CCLP.

Published
2020
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2. WAO International Scientific Conference (WISC 2016) Abstracts

Author

Jun Bao, Yi-Hui Wang, Quan-Hua Liu, Yi-Xiao Bao, Nurit Azouz, Julie Caldwell, Leanne Ray, Mark Rochman, Melissa Mingler, Matthew Eilerman, Ting Wen, Jocelyn Biagini Myers, Gurjit Khurana Hershey, Leah Kottyan, Lisa Martin, Rothenberg Marc, Victor Gonzalez-Uribe, Jaime Del Rio-Chivardi, Blanca Del Rio-Navarro, Hongfei Lou, Siyuan Ma, Yan Zhao, Feifei Cao, Fei He, Zhongyan Liu, Chengshuo Wang, Claus Bachert, Luo Zhang, Elissa Abrams, Allan Becker, Amit Kandhare, Subhash Bodhankar, Nicole Grossman, Gheorghe Doros, Francine Laden, Anne Fuhlbrigge, Michael Wechsler, Wilson Pace, Barbara Yawn, Elliot Israel, Junehyuk Lee, Frederick Adler, Peter Kim, Yung Feng Huang, Ying Yao Chen, Chiun Yen Pan, Herng Sheng Lee, Michael Khalemsky, David G. Schwartz, Pavel Kolkhir, Dmitry Pogorelov, Nikolay Kochergin, Hirsh Komarow, Michael Young, Robin Eisch, Linda Scott, Dean Metcalfe, Alexander Singer, Andrew Wakeman, Thomas Gerstner, Woo-Jung Song, Ji-Su Shim, Ha-Kyeong Won, Sung-Yoon Kang, Kyoung-Hee Sohn, Byung-Keun Kim, Eun-Jung Jo, Min-Hye Kim, Sang-Heon Kim, Heung-Woo Park, Sun-Sin Kim, Yoon-Seok Chang, Alyn H. Morice, Byung-Jae Lee, Sang-Heon Cho, Kyung-Up Min, Maria Assunta Boscolo, Giulio Brivio, Sergio Bosisio, Nicoletta Manzocchi, Edoardo Pulixi, Giulia Grignani, Eloisia D’Andrea, Massimo Ricci, Elena Passini, Maurizio Italia, Marilyn Urrutia-Pereira, Stefani Fagundes, Vinicius Jardim Oliano, Dirceu Solé, Sadia Benzaquen, Alejandro Aragaki, Ricardo Balestra, Dawn Harden, Danielle Caudell-Stamper, Gilbert Glady, Mark Holbreich, Nataliya Lyakhovska, Igor Kaidashev, Jaromir Bystron, Beata Hutyrova, Galina Balakirski, Luk Vanstreels, Gerda Wurpts, Hans F. Merk, Jens Malte Baron, Johanna Plange, Hans-Peter Rihs, Monika Raulf, Stefani Roeseler, Alberto Tolcachier, Armando Chamorro, Ruth Otero, Joel Brooks, Michael Hess, Jared Benz, Joseph MacDonald, Usma Chatha, Dale Lent, Şükran Köse, Bengü Gireniz Tatar, Gülgün Akkoçlu, İbrahim Çukurova, İlker Ödemiş, Ayşin Kılınç Toker, Abdullahi Hasssan, Abdulrazaq Abdullahi Gobir, Cheol-Woo Kim, Young Hwa Choi, Jeong Hye Lee, Rae Jeong Cho, Yu Ran Nam, Joo Hyun Nam, Woo Kyung Kim, Ivana Filipovic, Zorica Zivkovic, Djordje Filipovic, Dana Shik, Andrew Smith, Wang Yui Hsi, Stuart Friedman, Yonatan Gizaw, Rima Bakhda, Kumail Mohammed, Richard Wasserman, Angela Hague, Deanna Pence, Joanna Rolen, Robert Sugerman, Stacy Silvers, Qurat Kamili, Nadezhda Knauer, Alexandr Zazernyi, Elena Blinova, Daria Demina, Vladimir Kozlov, Komal Agrawal, Sagar Kale, Naveen Arora, Volha Vasilkova, Tatiana Mokhort, William Silvers, Rachel Eisenberg, Rushita Mehta, Arye Rubinstein, Antony Aston, Paul Turner, Monica Ruiz-Garcia, Robert Boyle, Simon Brown, Yael Dinur Schejter, Adi Ovadia, Vy Kim, Brenda Reid, Chaim Roifman, Lana Rosenfield, Ernie Avilla, Laurie Harada, Marilyn Allen, Susan Waserman, Ho Joo Yoon, Gun Woo Koo, Suk-Il Chang, Hye-Ran Yoon, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae Hyung Kim, Jang Won Sohn, Dong Ho Shin, Tsici Jorjoliani, Lia Jorjoliani, Nino Adamia, Nona katamadze, Deepika Ramachandra, Liana Jorjoliani, Rusudan Karseladze, Lali Saginadze, Natalia Chkuaseli, Anna Dolgova, Olga Stukolova, Anna Sudina, Anna Cherkashina, German Shipulin, Richard Rosenthal, Harvey Howe, Paul Knause, Rony Greemberg, Jean Jacques De Bruycker, Isabel Fernandez, Françoise Le Deist, Elie Haddad, Yeong Ho Rha, Kyung Suk Lee, Sun Hee Choi, Herman Tam, Estelle Simons, Elinor Simons, Maria Golebiowska-Wawrzyniak, Katarzyna Markiewicz, Yoram Faitelson, Miguel Stein, Avigdor Mandelberg, Ilan Dalal, Michael Levin, Lelani Hobane, Wisdom Basera, Maresa Botha, Claudia Gray, Heather Zar, Biserka Jovkovska Kjaeva, Zoran Arsovski, Vesna Grivcheva-Panovska, Adeyinka Odebode, Adedotun Adekunle, Peter Adeonipekun, Ebenezer Farombi, Nadezhda Camacho-Ordoñez, Alejandrina Josefina Martinez-Vázquez, María de la Luz H. García-Cruz, Qi Tan, Rui Min, Guan-qun Dai, Wei-Ping Xie, Huang Mao, Hong Wang, Rakesh Yadav, Sneha Singh, Divya Yadav, Ekaterina Khaleva, Henry T. Bahnson, Amber Franz, Lene Heise Garvey, Nicola Jay, Rubaiyat Haque, Adam Fox, Gideon Lack, George du Toit, Snezana Radic, Branislava Milenkovic, Ana Neskovic, Ljiljana Danojevic, Liat Nachshon, Michael Goldberg, Michael Levy, Yitzhak Katz, Arnon Elizur, Cristine Rosario, Juliana Kasper, Herbeto Chong-Neto, Carlos Riedi, Nelson Rosario, Michael B. Levy, Ronly Har-Even, Mor Carmel, Michael R. Goldberg, Maia Kherkheulidze, Nani Kavlashvili, Eka Kandelaki, Nino Adamai, Irma Ubiria, Andrea Burke, Monika Kastner, Denica Zheleva, Razvigor Darlenski, Konstantinos Bozinakis, Anastasios Kriebardis, Sofia Styliara, Aikaterini Karastathi, Nikolaos Farmakas, Maria Luiza Kraft Kohler Ribeiro, Ana Carolina Barcellos, Hannah Gabriele Ferreira Silva, Luís Henrique Mattei Carletto, Marcela Carolina Bet, Nathalia Zorze Rossetto, Nelson Augusto Rosario, Herberto Jose Chong-Neto, Fernanda Valença, Marina Novaes, Mariana Gomes, Carla Seifert, Alfredo Neto, Flavia Loyola, José Rios, Tatiana Silva, Aline Neves, Oznur Abadoglu, Bilun Gemicioglu, Hasan Bayram, Arif Cimrin, Levent Akyildiz, Aykut Cilli, Hakan Gunen, Tevfik Ozlu, Mecit Suerdem, Esra Uzaslan, Zeynep Misirligil, Snezana Ristic-Stojanovic, A. Milicevic, A. Milenkovic, Jelena Cvejic, Jelena Jankovic, Sanja Dimic-Janjic, Natasa Djurdjevic, Vladyslava Barzylovych, Tetiana Umanets, Anastasia Barzylovych, Karyn Winkler, Jessica Margarinos, Dylan Martin, Maja Nowakowski, Rauno Joks, Tsili Zangen, Olga Bernadsky, Mona Boaz, Gratiana Hermann, Rachel Aviv, Olga Kuperboim, Larisa Ramichanov, Efrat Broide, Raanan Shamir, Noam Zevit, Ron Shaoul, Alex Fich, Arie Levine, Isaac Melamed, Roopesh Singh Gangwar, Yael Minai-Fleminger, Mansour Seaf, Amichai Gutgold, Aarti Shikotra, Anoop Chauhan, Stephen Holgate, Peter Bradding, Peter Howarth, Ron Eliashar, Neville Berkman, Francesca Levi-Schaffer, Sung-il Woo, Betul Celik, Tangul Bulut, Arzu Didem Yalcin, Luiz Querino Caldas, Ronit Confino-Cohen, Yossi Rosman, Arnon Goldberg, Oded Breuer, Roopesh Singh, Ahlam Barhoum, Eitan Kerem, Tatiana Slavyanskaya, Revaz Sepiashvili, Elena A. Blinova, Ekaterina A. Pashkina, Marina I. Leonova, Vera M. Nepomnyaschikh, Darya V. Demina, Vladimir A. Kozlov, Revital Shamri, Kristen M. Young, Peter F. Weller, Rodolfo de Paula Vieira, Manoel Carneiro Oliveira-Junior, Nilsa Regina Damasceno-Rodrigues, Fernanda Magalhães Arantes-Costa, Milton Arruda Martins, Ana Paula Ligeiro Oliveira, Alfred Bernard, Antonia Sardella, Catherine Voisin, Simon Royce, Hamish Philpott, Sanjay Nandurkar, Francis Thien, Peter Gibson, Rodolfo Bianchini, Franziska Roth-Walter, Anna Ohradanova-Repic, Gerlinde Hofstetter, Ina Herrmann, Maria Isabel Carvalho, Karin Hufnagl, Erika Bajna, Georg Roth, Hannes Stockinger, Erika Jensen-Jarolim, Meital Almog, Aharon Kessel, Larisa Apov, Carlos Sanchez Salguero, Alvaro Sanchez Chacon, Abbos Nazarov, Shaxbos Ergashev, Irina Nesterova, Svetlana Kovaleva, Galina Chudilova, Ludmila Lomtatidze, Sarah De Schryver, Alizee Dery, Ann Clarke, Kari Nadeau, Kimberly Weatherall, Celia Greenwood, Denise Daley, Yuka Asai, Moshe Ben-Shoshan, Irina Balmasova, Elena Malova, Stefanie Wagner, Luis F. Pacios, Michael Wallner, Markus Wiederstein, Anna E. Tevs, Nataly Tataurshchikova, Baigalmaa Sangidorj, Anna Ronzhina, Manana Chikhladze, Oliver F. Wirz, Willem van de Veen, David Mirer, Hideaki Morita, Can Altunbulakli, Sebastian L. Johnston, Nicholas Glanville, Nikolaos G. Papadopoulos, Cezmi A. Akdis, Mübeccel Akdis, Avner Reshef, Marc Riedl, Vesna Grivcheva Panovska, Dumitru Moldovan, James Baker, William H. Yang, Sladjana Andrejevic, Richard F. Lockey, Roman Hakl, Shmuel Kivity, Luca Bellizzi, Joseph R. Harper, Anurag Relan, and Marco Cicardi

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2017
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3. Phenological shifts of abiotic events, producers and consumers across a continent

Author

Svetlana Igosheva, Natalia Belyaeva, Aleksandra Krasnopevtseva, Aleksey Tomilin, Yuri Buyvolov, Tatiana Akimova, Aleksey Kudryavtsev, Irina Kozyr, Olga Rozhkova, Olga Ermakova, Yurij Tyukh, Evgeniy A. Davydov, Ozodbek Abduraimov, Elvira Kotlugalyamova, Mykhailo Motruk, Elena B. Pospelova, Natalia Korotkikh, Vladislav Timoshkin, Rustam Sibgatullin, Irina Fedchenko, Dmitrij Golovcov, Andrey S. Kuznetsov, Irina Nesterova, Tatyana Zubina, Galina Sokolova, Yuri Bykov, Miroslav Babushkin, Tomas Roslin, Helen Korolyova, Elena Smirnova, Sergei Stepanov, S. Sazonov, Evgeniy Meyke, Murad Kurbanbagamaev, Svetlana Bondarchuk, Sergey Kossenko, Darya Kiseleva, Vasyl Shevchyk, Alexander Hritankov, Elena Sitnikova, Oleg Bakin, Tatyana Gordeeva, Ludmila Dostoyevskaya, Irina Gaydysh, Margarita Kupriyanova, Coong Lo, Yuliia Kulsha, Vladimir Van, Elena Bochkareva, Mirabdulla Turgunov, Tatiana Filatova, Marina Yakovleva, Lilija Sultangareeva, Fedor Kazansky, P. D. Lebedev, Irina Megalinskaja, Akynaly Dubanaev, Elena Chakhireva, Elena Diadicheva, Aleksandra Esengeldenova, Juri Kurhinen, Tamara Nezdoliy, Maria Hällfors, Maxim Antipin, Alla Kozurak, Kirill Litvinov, Nicolay Zelenetskiy, Leonid Kolpashikov, Ksenia Shalaeva, Elena Andreeva, Vladimir Yakovlev, Ludmila Gromyko, Miroslava Sahnevich, Tatiana Polyanskaya, Viktor Mamontov, Valeri Sanko, Evgeniya Kaygorodova, Tatiana Tertitsa, Andrey Zahvatov, Nadezhda Kuyantseva, Anatoly Bobretsov, Oleg Mitrofanov, Elena Shujskaja, Aleksandr Ananin, Viktor Teplov, Valentina Teplova, Alexander Sukhov, Vladimir Hohryakov, Natalya Ivanova, Nadezhda Kutenkova, Yury Kalinkin, Gleb Tikhonov, Lidiya Makovkina, Lidia Epova, Alexey Pavlov, Anatolii Zheltukhin, Uliya Ivanova, María del Mar Delgado, Aleksandr Myslenkov, Evgeniya Bukharova, Guzalya Suleymanova, Gennady Bogdanov, Natalia Luzhkova, Irina Rybnikova, Nadezhda Goncharova, Nikolay Volodchenkov, Nataliya Skok, Yuri Rozhkov, Viktorija Teleganova, Aleksandr Minin, Vladimir Bobrov, Zoya Drozdova, Nina Belova, Irina Prokosheva, Svetlana Babina, Lidia Vetchinnikova, Svetlana Mayorova, Artur Meydus, Evgeny Kozlovsky, Violetta Strekalovskaya, Yurij Yarema, Ilya Prokhorov, Elena Ignatenko, Nadezhda Cherenkova, Tatyana Niroda, Vitalіy Stratiy, Valery Zakharov, Olga Chashchina, Oleg Evstigneev, Sergey Elsukov, Maksim Shashkov, Evgenii Korobov, Sergej Shubin, Ivan Putrashyk, Darya Panicheva, Klara Pavlova, Anatoliy Kutenkov, Ludmila Tselishcheva, Elena Ershkova, Vadim Bobrovskyi, Dmitry Tirski, Laura H. Antão, Vladimir Sopin, Olga Kuberskaya, Svetlana Skorokhodova, Svetlana Drovnina, Vladislav Vinogradov, Natalia Andriychuk, Sergey Kruglikov, Anatoliy Gavrilov, Anatoliy Vekliuk, Olga S Ermakova, Aleksandra Vasina, Anna Barabancova, Muzhigit Akkiev, Vladimir Kozsheechkin, Andrei Sivkov, Otso Ovaskainen, Polina Van, Azizbek Mahmudov, Anastasia A. Knorre, Julia Raiskaya, Evgeniya Bisikalova, Inna Basilskaja, Svetlana Chuhontseva, Anatoliy Shcherbakov, Vladimir Bolshakov, Alexander Samoylov, Igor N. Pospelov, Sergej Chistjakov, Viktor Demchenko, Natalia Nemtseva, Sergei Podolski, Alena Butunina, Gennadiy Kosenkov, Tatiana Novikova, Aleksandr Dobrolyubov, Andrej Tolmachev, Oksana Yantser, Yuriy Dubrovsky, Lyudmila Puchnina, Sergey Gashev, Natalia Sikkila, Violetta Fedotova, Zoya Selyunina, Evgeniy Larin, Inna Voloshina, Marina Rudenko, Elena Kulebyakina, Natalja Polikarpova, Aleksander Vasin, Yurii Spasovski, Olga Adrianova, Vitaly Grishchenko, Konstantin Arzamascev, Eliezer Gurarie, Svetlana Rykova, Elena E. Gorbunova, Nina Nasonova, Inna Sapelnikova, Marina Abadonova, Eugenia Yablonovska-Grishchenko, Anna Buyvolova, Tatjana Bespalova, Tura Xoliqov, University of Helsinki, Department of Agricultural Sciences, Biosciences, Spatial Foodweb Ecology Group, Research Centre for Ecological Change, Organismal and Evolutionary Biology Research Programme, Plant Adaptation and Conservation, Helsinki Institute of Sustainability Science (HELSUS), Unit of Biodiversity Informatics, Otso Ovaskainen / Principal Investigator, Academy of Finland, European Commission, Jane and Aatos Erkko Foundation, Research Council of Norway, Kone Foundation, and Russian Academy of Sciences

Subjects
IMPACTS, 1171 Geosciences, 010504 meteorology & atmospheric sciences, AUTUMN, SEASON, Climate change, Ecosystem integrity, Environmental Science (miscellaneous), 01 natural sciences, Latitude, 03 medical and health sciences, Community ecology, skin and connective tissue diseases, 1172 Environmental sciences, 030304 developmental biology, 0105 earth and related environmental sciences, Trophic level, Abiotic component, 0303 health sciences, CLIMATE-CHANGE, Ecology, Phenology, FLOWERING PHENOLOGY, COMMUNITY, VARIABILITY, Geography, Taxon, Habitat, 13. Climate action, TROPHIC LEVELS, sense organs, MARINE, Social Sciences (miscellaneous), RESPONSES
Abstract

Ongoing climate change can shift organism phenology in ways that vary depending on species, habitats and climate factors studied. To probe for large-scale patterns in associated phenological change, we use 70,709 observations from six decades of systematic monitoring across the former Union of Soviet Socialist Republics. Among 110 phenological events related to plants, birds, insects, amphibians and fungi, we find a mosaic of change, defying simple predictions of earlier springs, later autumns and stronger changes at higher latitudes and elevations. Site mean temperature emerged as a strong predictor of local phenology, but the magnitude and direction of change varied with trophic level and the relative timing of an event. Beyond temperature-associated variation, we uncover high variation among both sites and years, with some sites being characterized by disproportionately long seasons and others by short ones. Our findings emphasize concerns regarding ecosystem integrity and highlight the difficulty of predicting climate change outcomes., The work was financially supported by the Academy of Finland, grants 250243 (O.O.), 284601 (O.O.), 309581 (O.O.); the European Research Council, ERC Starting Grant 205905 (O.O.) and Synergy Grant 856506 – LIFEPLAN (to O.O. and T.R.); Nordic Environment Finance Corporation Grant (O.O.); Jane and Aatos Erkko Foundation Grant (O.O., T.R., M.H., L.A.); University of Helsinki HiLIFE Fellow Grant 2017–2020 (O.O.); and the Research Council of Norway through its Centres of Excellence Funding Scheme (223257) to O.O. via Centre for Biodiversity Dynamics; the Kone Foundation 44-6977 (M.D.) and 55-14839 (G.T.); a Spanish Ramon y Cajal grant RYC-2014-16263 (M.D.); the Federal Budget for the Forest Research Institute of Karelian Research Centre Russian Academy of Sciences 220-2017-0003, 0220-2017-0005 (L.V., S.S. and J.K.); the Russian Foundation for Basic Research Grant 16-08-00510 (L.K.), and the Ministry of Education and Science of the Russian Federation 0017-2019-0009 (Keldysh Institute of Applied Mathematics, Russian Academy of Sciences) (N.I., M. Shashkov).

Published
2021
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4. Differences in spatial versus temporal reaction norms for spring and autumn phenological events

Author

Olga Rozhkova, Elena Kulebyakina, Svetlana Babina, Olga Ermakova, Natalja Polikarpova, Anatolii Zheltukhin, Vladimir Bolshakov, Violetta Strekalovskaya, Olga Kuberskaya, Natalia Belyaeva, Aleksander Vasin, Darya Panicheva, Anatoliy Kutenkov, Elvira Kotlugalyamova, Artur Meydus, Aleksey Tomilin, Ludmila Tselishcheva, Mykhailo Motruk, Evgeny Kozlovsky, Yuri Buyvolov, Elena B. Pospelova, Natalia Korotkikh, Vadim Bobrovskyi, Anna Barabancova, Vitalіy Stratiy, Natalia Andriychuk, Margarita Kupriyanova, Dmitry Tirski, Klara Pavlova, Elena Andreeva, Tatyana Gordeeva, Ludmila Dostoyevskaya, Irina Kozyr, Yuriy Dubrovsky, Zoya Selyunina, Andrei Sivkov, Muzhigit Akkiev, Vladimir Kozsheechkin, Nataliya Skok, Viktorija Teleganova, Azizbek Mahmudov, Yurij Yarema, Elena Ershkova, Rustam Sibgatullin, Dmitrij Golovcov, Kirill Litvinov, Aleksey Kudryavtsev, Nadezhda Kuyantseva, Elena Shujskaja, Anastasia A. Knorre, Coong Lo, Mirabdulla Turgunov, Tatiana Filatova, Yurij Tyukh, Gennadiy Kosenkov, Aleksandra Esengeldenova, Lyudmila Puchnina, Tatyana Zubina, Alla Kozurak, Vladimir Hohryakov, Maxim Antipin, Svetlana Mayorova, Nikolay Volodchenkov, Eugenia Yablonovska-Grishchenko, Miroslava Sahnevich, Vladimir Yakovlev, Ludmila Gromyko, Tatiana Polyanskaya, Tatiana Novikova, Alexander Samoylov, Aleksandr Dobrolyubov, Helen Korolyova, Nicolay Zelenetskiy, Leonid Kolpashikov, S. Sazonov, Polina Van, Olga Adrianova, Evgeniy Meyke, Viktor Teplov, Valeri Sanko, Ilya Prokhorov, Elena Ignatenko, Tatyana Niroda, Nina Belova, Andrey Zahvatov, Aleksandr Ananin, Vitaly Grishchenko, Konstantin Arzamascev, María del Mar Delgado, Irina Prokosheva, Aleksandr Myslenkov, Yuri Rozhkov, Nadezhda Cherenkova, Svetlana Chuhontseva, Anna Buyvolova, Sergey Gashev, Natalya Ivanova, Nadezhda Kutenkova, Anatoliy Shcherbakov, Evgeniya Kaygorodova, Valentina Teplova, Nadezhda Goncharova, Oleg Mitrofanov, Svetlana Igosheva, Igor N. Pospelov, Sergej Chistjakov, Oleg Evstigneev, Sergey Elsukov, Maksim Shashkov, Ozodbek Abduraimov, Vladislav Timoshkin, Vasyl Shevchyk, Irina Fedchenko, Otso Ovaskainen, Galina Sokolova, Sergei Stepanov, Aleksandr Minin, Vladimir Bobrov, Sergey Kruglikov, Valery Zakharov, Miroslav Babushkin, Murad Kurbanbagamaev, Svetlana Bondarchuk, Lidiya Makovkina, Sergej Shubin, Zoya Drozdova, Tatjana Bespalova, Olga Chashchina, Yury Kalinkin, Natalia Sikkila, Alexander Hritankov, Ivan Putrashyk, Tura Xoliqov, Anatoliy Vekliuk, Evgenii Korobov, Alexey Pavlov, Yuliia Kulsha, Aleksandra Vasina, Aleksandra Krasnopevtseva, Marina Yakovleva, Lilija Sultangareeva, P. D. Lebedev, Gleb Tikhonov, Anatoly Bobretsov, Anatoliy Gavrilov, Andrej Tolmachev, Irina Megalinskaja, Uliya Ivanova, Viktor Mamontov, Lidia Epova, Gennady Bogdanov, Natalia Nemtseva, Tatiana Akimova, Sergei Podolski, Olga S Ermakova, Tatiana Tertitsa, Guzalya Suleymanova, Alexander Sukhov, Alena Butunina, Natalia Luzhkova, Tomas Roslin, Oksana Yantser, Evgeniya Bisikalova, Irina Rybnikova, Evgeniya Bukharova, Vladimir Sopin, Lidia Vetchinnikova, Darya Kiseleva, Inna Basilskaja, Evgeniy A. Davydov, Violetta Fedotova, Yuri Bykov, Vladimir Van, Sergey Kossenko, Juri Kurhinen, Elena Smirnova, Elena Bochkareva, Elena Sitnikova, Elena Chakhireva, Elena Diadicheva, Viktor Demchenko, Andrey S. Kuznetsov, Irina Nesterova, Fedor Kazansky, Irina Gaydysh, Tamara Nezdoliy, Svetlana Skorokhodova, Marina Abadonova, Svetlana Drovnina, Akynaly Dubanaev, Oleg Bakin, Ksenia Shalaeva, Eliezer Gurarie, Svetlana Rykova, Elena E. Gorbunova, Nina Nasonova, Inna Sapelnikova, Evgeniy Larin, Inna Voloshina, Marina Rudenko, Yurii Spasovski, Julia Raiskaya, Vladislav Vinogradov, Helsinki Institute of Sustainability Science (HELSUS), Organismal and Evolutionary Biology Research Programme, and Research Centre for Ecological Change

Subjects
0106 biological sciences, 010504 meteorology & atmospheric sciences, Climate Change, Lag, Population, Climate change, heating, Biology, COUNTERGRADIENT, phenology, 010603 evolutionary biology, 01 natural sciences, LOCAL ADAPTATION, PHENOTYPIC PLASTICITY, 1ST FLOWERING DATES, medicine, Animals, chilling, PLANT, education, METAANALYSIS, Ecosystem, 0105 earth and related environmental sciences, Local adaptation, education.field_of_study, Phenotypic plasticity, CLIMATE-CHANGE, Multidisciplinary, EVOLUTIONARY SIGNIFICANCE, Ecology, Phenology, Temperature, Biological Sciences, Seasonality, medicine.disease, Adaptation, Physiological, ECOLOGICAL RESPONSES, plasticity, 1181 Ecology, evolutionary biology, Spatial variability, TEMPERATURE-MEDIATED SHIFTS, Seasons, Environmental Monitoring, USSR
Abstract

European Research Council (ERC) Starting Grant 205905 (to O.O.) and Synergy Grant 856506—LIFEPLAN (to O.O. and T.R.); Spanish Ramón y Cajal Grant RYC-2014-16263 (to M.M.D.) (...), Delgado, M.D.M., Roslin, T., Tikhonov, G., Meyke, E., Lo, C., Gurarie, E., Abadonova, M., Abduraimov, O., Adrianova, O., Akimova, T., Akkiev, M., Ananin, A., Andreeva, E., Andriychuk, N., Antipin, M., Arzamascev, K., Babina, S., Babushkin, M., Bakin, O., Barabancova, A., Basilskaja, I., Belova, N., Belyaeva, N., Bespalova, T., Bisikalova, E., Bobretsovz, A., Bobrov, V., Bobrovskyi, V., Bochkareva, E., Bogdanov, G., Bolshakov, V., Bondarchuk, S., Bukharova, E., Butunina, A., Buyvolov, Y., Buyvolova, A., Bykov, Y., Chakhireva, E., Chashchina, O., Cherenkova, N., Chistjakov, S., Chuhontseva, S., Davydov, E.A., Demchenko, V., Diadicheva, E., Dobrolyubov, A., Dostoyevskaya, L., Drovnina, S., Drozdova, Z., Dubanaev, A., Dubrovsky, Y., Elsukov, S., Epova, L., Ermakova, O.S., Ermakova, O., Esengeldenova, A., Evstigneev, O., Fedchenko, I., Fedotova, V., Filatova, T., Gashev, S., Gavrilov, A., Gaydys, I., Golovcov, D., Goncharova, N., Gorbunova, E., Gordeeva, T., Grishchenko, V., Gromyko, L., Hohryakov, V., Hritankov, A., Ignatenko, E., Igosheva, S., Ivanova, U., Ivanova, N., Kalinkin, Y., Kaygorodova, E., Kazansky, F., Kiseleva, D., Knorrem, A., Kolpashikov, L., Korobov, E., Korolyova, H., Korotkikh, N., Kosenkov, G., Kossenko, S., Kotlugalyamova, E., Kozlovsky, E., Kozsheechkin, V., Kozurak, A., Kozyr, I., Krasnopevtseva, A., Krugliko, S., Kuberskaya, O., Kudryavtsev, A., Kulebyakina, E., Kulsha, Y., Kupriyanova, M., Kurbanbagamaev, M., Kutenkov, A., Kutenkova, N., Kuyantseva, N., Kuznetsov, A., Larin, E., Lebedev, P., Litvinov, K., Luzhkova, N., Mahmudov, A., Makovkina, L., Mamontov, V., Mayorova, S., Megalinskaja, I., Meydus, A., Minin, A., Mitrofanov, O., Motruk, M., Myslenkov, A., Nasonova, N., Nemtseva, N., Nesterova, I., Nezdoliy, T., Niroda, T., Novikova, T., Panicheva, D., Pavlov, A., Pavlova, K., Van, P., Podolski, S., Polikarpova, N., Tatiana Polyanskaya81, Pospelov, I., Pospelova, E., Prokhorov, I., Prokosheva, I., Puchnina, L., Putrashyk, I., Raiskaya, J., Rozhkov, Y., Rozhkova, O., Rudenko, M., Rybnikova, I., Rykova, S., Sahnevich, M., Samoylov, A., Sank, V., Sapelnikova, I., Sazonov, S., Selyunina, Z., Shalaeva, K., Shashkov, M., Shcherbakov, A., Shevchyk, V., Shubin, S., Shujskaja, E., Sibgatullin, R., Sikkilah, N., Sitnikova, E., Sivkov, A., Skok, N., Skorokhodova, S., Smirnova, E., Sokolova, G., Sopin, V., Spasovski, Y., Stepanov, S., Stratiy, V., Strekalovskaya, V., Sukhov, A., Suleymanova, G., Sultangareeva, L., Teleganova, V., Teplov, V., Teplova, V., Tertitsa, T., Timoshkin, V., Tirski, D., Tolmachev, A., Tomilin, A., Tselishcheva, L., Turgunov, M., Tyukh, Y., Van, V., Ershkova, E., Vasin, A., Vasina, A., Vekliuk, A., Vetchinnikova, L., Vinogradov, V., Volodchenko, N., Voloshina, I., Xoliqov, T., Yablonovska-Grishchenko, E., Yakovlev, V., Yakovleva, M., Yantser, O., Yarema, Y., Zahvatov, A., Zakharov, V., Zelenetskiy, N., Zheltukhin, A., Zubina, T., Kurhinen, J., Ovaskainen, O.

Published
2020
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5. Author Correction: Chronicles of nature calendar, a long-term and large-scale multitaxon database on phenology

Author

Elena Kulebyakina, Natalja Polikarpova, Kirill Litvinov, Vladimir Yakovlev, Ludmila Gromyko, Tatiana Polyanskaya, Aleksander Vasin, Akynaly Dubanaev, Dmitry Tirski, Anatoliy Shcherbakov, Valeri Sanko, Valery Zakharov, Evgeniy Larin, Inna Voloshina, Marina Rudenko, Lidiya Makovkina, Olga Chashchina, Azizbek Mahmudov, Svetlana Igosheva, Anastasia A. Knorre, Evgenii Korobov, Olga Rozhkova, Irina Fedchenko, Yurii Spasovski, Olga Ermakova, Artur Meydus, Violetta Fedotova, Aleksandr Myslenkov, Elena B. Pospelova, Natalia Korotkikh, Evgeny Kozlovsky, Alexander Samoylov, Miroslav Babushkin, Coong Lo, Mirabdulla Turgunov, Tatiana Filatova, Murad Kurbanbagamaev, Svetlana Bondarchuk, Aleksandra Esengeldenova, Ozodbek Abduraimov, Ksenia Shalaeva, Vladislav Timoshkin, Yurij Yarema, Nadezhda Goncharova, Galina Sokolova, Sergei Stepanov, Zoya Selyunina, Juri Kurhinen, Tomas Roslin, Elvira Kotlugalyamova, Yuliia Kulsha, Marina Yakovleva, Lilija Sultangareeva, Svetlana Chuhontseva, Yuriy Dubrovsky, Anatolii Zheltukhin, Mykhailo Motruk, Nikolay Volodchenkov, Lyudmila Puchnina, Eliezer Gurarie, P. D. Lebedev, Nina Belova, Irina Prokosheva, Tatyana Gordeeva, Svetlana Skorokhodova, Sergey Kossenko, Ludmila Dostoyevskaya, Svetlana Babina, Elena Sitnikova, Yuri Rozhkov, Svetlana Rykova, Igor N. Pospelov, Sergej Chistjakov, Nadezhda Cherenkova, Sergey Gashev, Vladimir Sopin, Olga Adrianova, Violetta Strekalovskaya, Irina Gaydysh, Natalia Sikkila, Viktor Teplov, Rustam Sibgatullin, Julia Raiskaya, Vitalіy Stratiy, Aleksandr Minin, Vitaly Grishchenko, Konstantin Arzamascev, Vladimir Bobrov, Marina Abadonova, Helen Korolyova, S. Sazonov, Evgeniy Meyke, Darya Panicheva, Dmitrij Golovcov, Tatiana Akimova, Natalia Belyaeva, Nicolay Zelenetskiy, Vladislav Vinogradov, Tatyana Zubina, Zoya Drozdova, Andrey Zahvatov, Anatoliy Kutenkov, Elena E. Gorbunova, Nina Nasonova, Leonid Kolpashikov, Gennadiy Kosenkov, Aleksey Tomilin, Elena Vargot, Anatoliy Vekliuk, Aleksandra Vasina, Yuri Buyvolov, Vasyl Shevchyk, Vladimir Hohryakov, Ludmila Tselishcheva, Andrej Tolmachev, Tatiana Novikova, Aleksandr Ananin, Oksana Yantser, Natalya Ivanova, Nadezhda Kutenkova, Van Vladimir, Polina Petrenko, Inna Sapelnikova, Aleksandr Dobrolyubov, Yury Kalinkin, Viktor Mamontov, Vadim Bobrovskyi, Svetlana Drovnina, Aleksey Kudryavtsev, Uliya Ivanova, Tatiana Tertitsa, Alexander Sukhov, Guzalya Suleymanova, Natalia Andriychuk, Otso Ovaskainen, Vladimir Bolshakov, Lidia Vetchinnikova, Gennady Bogdanov, Oleg Bakin, Natalia Luzhkova, Irina Rybnikova, Margarita Kupriyanova, Sergey Kruglikov, Andrey S. Kuznetsov, Irina Nesterova, María del Mar Delgado, Alla Kozurak, Miroslava Sahnevich, Aleksandra Krasnopevtseva, Gleb Tikhonov, Tatjana Bespalova, Evgeniy A. Davydov, Tura Xoliqov, Eugenia Yablonovska-Grishchenko, Anna Buyvolova, Yuri Bykov, Anatoliy Gavrilov, Elena Smirnova, Olga S Ermakova, Elena Andreeva, Oleg Mitrofanov, Darya Kiseleva, Nadezhda Kuyantseva, Elena Shujskaja, Elena Bochkareva, Fedor Kazansky, Alexander Hritankov, Irina Megalinskaja, Olga Kuberskaya, Irina Kozyr, Yurij Tyukh, Klara Pavlova, Oleg Evstigneev, Sergey Elsukov, Maksim Shashkov, Sergej Shubin, Ivan Putrashyk, Nataliya Skok, Viktorija Teleganova, Svetlana Mayorova, Ilya Prokhorov, Elena Ignatenko, Elena Chakhireva, Elena Diadicheva, Tatyana Niroda, Tamara Nezdoliy, Alexey Pavlov, Anatoly Bobretsov, Natalia Nemtseva, Lidia Epova, Sergei Podolski, Alena Butunina, Evgeniya Bukharova, Anna Barabancova, Maxim Antipin, Andrei Sivkov, Evgeniya Kaygorodova, Valentina Teplova, Evgeniya Bisikalova, Inna Basilskaja, Viktor Demchenko, Muzhigit Akkiev, and Vladimir Kozsheechkin

Subjects
Statistics and Probability, Data Descriptor, Databases, Factual, Republic of Belarus, Climate Change, Scale (descriptive set theory), Library and Information Sciences, Russia, Education, Combinatorics, Author Correction, Kyrgyzstan, lcsh:Science, Mathematics, Phenology, Published Erratum, Uzbekistan, Biodiversity, Biota, Term (time), Computer Science Applications, lcsh:Q, Seasons, Statistics, Probability and Uncertainty, Ukraine, Information Systems
Abstract

We present an extensive, large-scale, long-term and multitaxon database on phenological and climatic variation, involving 506,186 observation dates acquired in 471 localities in Russian Federation, Ukraine, Uzbekistan, Belarus and Kyrgyzstan. The data cover the period 1890–2018, with 96% of the data being from 1960 onwards. The database is rich in plants, birds and climatic events, but also includes insects, amphibians, reptiles and fungi. The database includes multiple events per species, such as the onset days of leaf unfolding and leaf fall for plants, and the days for first spring and last autumn occurrences for birds. The data were acquired using standardized methods by permanent staff of national parks and nature reserves (87% of the data) and members of a phenological observation network (13% of the data). The database is valuable for exploring how species respond in their phenology to climate change. Large-scale analyses of spatial variation in phenological response can help to better predict the consequences of species and community responses to climate change., Measurement(s)phenological event • climateTechnology Type(s)digital curationFactor Type(s)geographic location • yearSample Characteristic - LocationRussia • Ukraine • Uzbekistan • Belarus • Kyrgyzstan Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.11687169

Published
2020
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6. Chronicles of nature calendar, a long-term and large-scale multitaxon database on phenology

Author

Viktor Teplov, Oleg Bakin, Andrey Zahvatov, Svetlana Skorokhodova, Aleksandr Ananin, Natalya Ivanova, Nadezhda Kutenkova, Van Vladimir, Olga Adrianova, Darya Kiseleva, Vitaly Grishchenko, Konstantin Arzamascev, Tomas Roslin, Andrey Kuznetsov, Elena E. Gorbunova, Svetlana Igosheva, Nina Nasonova, Anatoly Bobretsov, Elena Bochkareva, Elena Vargot, Inna Sapelnikova, Eliezer Gurarie, Sergey Kossenko, Svetlana Rykova, Fedor Kazansky, Andrej Tolmachev, Natalia Nemtseva, Sergei Podolski, Elena Sitnikova, Lidia Epova, Evgeniy Larin, Inna Voloshina, Marina Rudenko, Oksana Yantser, Alena Butunina, Svetlana Drovnina, Irina Gaydysh, Evgeniya Bisikalova, Ozodbek Abduraimov, Evgeniya Bukharova, Vladislav Vinogradov, Yurii Spasovski, Svetlana Chuhontseva, Gennady Bogdanov, Valery Zakharov, Yury Kalinkin, Inna Basilskaja, Vladislav Timoshkin, Oleg Evstigneev, Akynaly Dubanaev, Yuri Bykov, Elena Smirnova, Violetta Fedotova, Uliya Ivanova, Natalia Luzhkova, Kirill Litvinov, Sergey Elsukov, Maksim Shashkov, Olga Chashchina, Galina Sokolova, Sergei Stepanov, Irina Rybnikova, Elena Chakhireva, Tatjana Bespalova, Margarita Kupriyanova, Igor N. Pospelov, Sergej Chistjakov, Vladimir Yakovlev, Ludmila Gromyko, Elena Diadicheva, Elena Andreeva, Zoya Selyunina, Evgenii Korobov, Guzalya Suleymanova, Sergej Shubin, Yuriy Dubrovsky, Viktor Demchenko, Tatiana Polyanskaya, Valeri Sanko, Olga Rozhkova, Elena B. Pospelova, Natalia Korotkikh, Sergey Kruglikov, Irina Kozyr, Svetlana Babina, Ivan Putrashyk, Lyudmila Puchnina, Tamara Nezdoliy, Tura Xoliqov, Anna Barabancova, Alla Kozurak, Elena Kulebyakina, Natalja Polikarpova, Nadezhda Kuyantseva, Olga Ermakova, Ksenia Shalaeva, Nikolay Volodchenkov, Lidia Vetchinnikova, Coong Lo, Yurij Tyukh, Tatiana Akimova, Natalia Belyaeva, Irina Fedchenko, Elena Shujskaja, Mirabdulla Turgunov, Tatiana Filatova, Gennadiy Kosenkov, Sergey Gashev, Violetta Strekalovskaya, Aleksandra Esengeldenova, Miroslava Sahnevich, Nataliya Skok, Viktorija Teleganova, Aleksey Tomilin, Aleksander Vasin, Tatyana Gordeeva, Alexey Pavlov, Yuri Buyvolov, Andrei Sivkov, Ludmila Dostoyevskaya, Natalia Sikkila, Svetlana Mayorova, Tatiana Novikova, Miroslav Babushkin, Aleksandr Dobrolyubov, Ilya Prokhorov, Murad Kurbanbagamaev, Svetlana Bondarchuk, Marina Abadonova, Elena Ignatenko, Yuri Rozhkov, Tatyana Niroda, Vitalіy Stratiy, Aleksey Kudryavtsev, Klara Pavlova, Anatoliy Gavrilov, Oleg Mitrofanov, Alexander Hritankov, Aleksandr Myslenkov, Elvira Kotlugalyamova, Nicolay Zelenetskiy, Leonid Kolpashikov, Olga S Ermakova, Anatolii Zheltukhin, Vladimir Bolshakov, Mykhailo Motruk, Maxim Antipin, Dmitry Tirski, Muzhigit Akkiev, Vladimir Kozsheechkin, Yuliia Kulsha, Marina Yakovleva, Lilija Sultangareeva, Eugenia Yablonovska-Grishchenko, Evgeniya Kaygorodova, P. D. Lebedev, Irina Megalinskaja, Valentina Teplova, Nadezhda Goncharova, Rustam Sibgatullin, Anna Buyvolova, Otso Ovaskainen, Vladimir Hohryakov, Anatoliy Shcherbakov, Olga Kuberskaya, Dmitrij Golovcov, Tatyana Zubina, Aleksandr Minin, Julia Raiskaya, María del Mar Delgado, Vladimir Bobrov, Zoya Drozdova, Vladimir Sopin, Artur Meydus, Evgeny Kozlovsky, Azizbek Mahmudov, Anastasia A. Knorre, Yurij Yarema, Alexander Samoylov, Aleksandra Krasnopevtseva, Gleb Tikhonov, Evgeniy A. Davydov, Anatoliy Vekliuk, Aleksandra Vasina, Polina Petrenko, Irina Nesterova, Natalia Andriychuk, Viktor Mamontov, Nina Belova, Irina Prokosheva, Tatiana Tertitsa, Alexander Sukhov, Nadezhda Cherenkova, Helen Korolyova, S. Sazonov, Evgeniy Meyke, Lidiya Makovkina, Vasyl Shevchyk, Darya Panicheva, Anatoliy Kutenkov, Ludmila Tselishcheva, Juri Kurhinen, Vadim Bobrovskyi, Research Centre for Ecological Change, Otso Ovaskainen / Principal Investigator, Organismal and Evolutionary Biology Research Programme, Unit of Biodiversity Informatics, and University of Helsinki

Subjects
IMPACTS, 0106 biological sciences, Statistics and Probability, 010504 meteorology & atmospheric sciences, Climate change, Library and Information Sciences, computer.software_genre, 010603 evolutionary biology, 01 natural sciences, Education, HISTORY, lcsh:Science, 1172 Environmental sciences, 0105 earth and related environmental sciences, Trophic level, Nature reserve, CLIMATE-CHANGE, Database, Phenology, Biota, Computer Science Applications, Term (time), Geography, TROPHIC LEVELS, 1181 Ecology, evolutionary biology, Period (geology), lcsh:Q, Spatial variability, SENSITIVITY, Statistics, Probability and Uncertainty, computer, RESPONSES, Information Systems
Abstract

The work was funded by Academy of Finland, grants 250243, 284601, 309581 (OO); the European Research Council, ERC Starting Grant 205905 (OO); Nordic Environment Finance Corporation Grant (OO); Jane and Aatos Erkko Foundation Grant (OO and TR); University of Helsinki HiLIFE Fellow Grant 2017–2020 (OO); the Kone Foundation 44-6977 (MD); Spanish Ramon y Cajal grant RYC-2014-16263 (MD); the Federal Budget for the Forest Research Institute of Karelian Research Centre Russian Academy of Sciences 220-2017-0003,0220-2017-0005 (LV, SS and JK); the Russian Foundation for Basic Research Grant 16-08-00510 (LK), and the Ministry of Education and Science of the Russian Federation 0017-2019-0009 (Keldysh Institute of Applied Mathematics, Russian Academy of Sciences) (NI, MSh)., Ovaskainen, O., Meyke, E., Lo, C., Tikhonov, G., Delgado, M.M., Roslin, T., Gurarie, E., Abadonova, M., Abduraimov, O., Adrianova, O., Akimova, T., Akkiev, M., Ananin, A., Andreeva, E., Andriychuk, N., Antipin, M., Arzamascev, K., Babina, S., Babushkin, M., Bakin, O., Barabancova, A., Basilskaja, I., Belova, N., Belyaeva, N., Bespalova, T., Bisikalova, E., Bobretsov, A., Bobrov, V., Bobrovskyi, V., Bochkareva, E., Bogdanov, G., Bolshakov, V., Bondarchuk, S., Bukharova, E., Butunina, A., Buyvolov, Y., Buyvolova, A., Bykov, Y., Chakhireva, E., Chashchina, O., Cherenkova, N., Chistjakov, S., Chuhontseva, S., Davydov, E.A., Demchenko, V., Diadicheva, E., Dobrolyubov, A., Dostoyevskaya, L., Drovnina, S., Drozdova, Z., Dubanaev, A., Dubrovsky, Y., Elsukov, S., Epova, L., Ermakova, O.S., Ermakova, O., Esengeldenova, A., Evstigneev, O., Fedchenko, I., Fedotova, V., Filatova, T., Gashev, S., Gavrilov, A., Gaydysh, I., Golovcov, D., Goncharova, N., Gorbunova, E., Gordeeva, T., Grishchenko, V., Gromyko, L., Hohryakov, V., Hritankov, A., Ignatenko, E., Igosheva, S., Ivanova, U., Ivanova, N., Kalinkin, Y., Kaygorodova, E., Kazansky, F., Kiseleva, D., Knorre, A., Kolpashikov, L., Korobov, E., Korolyova, H., Korotkikh, N., Kosenkov, G., Kossenko, S., Kotlugalyamova, E., Kozlovsky, E., Kozsheechkin, V., Kozurak, A., Kozyr, I., Krasnopevtseva, A., Kruglikov, S., Kuberskaya, O., Kudryavtsev, A., Kulebyakina, E., Kulsha, Y., Kupriyanova, M., Kurbanbagamaev, M., Kutenkov, A., Kutenkova, N., Kuyantseva, N., Kuznetsov, A., Larin, E., Lebedev, P., Litvinov, K., Luzhkova, N., Mahmudov, A., Makovkina, L., Mamontov, V., Mayorova, S., Megalinskaja, I., Meydus, A., Minin, A., Mitrofanov, O., Motruk, M., Myslenkov, A., Nasonova, N., Nemtseva, N., Nesterova, I., Nezdoliy, T., Niroda, T., Novikova, T., Panicheva, D., Pavlov, A., Pavlova, K., Petrenko, P., Podolski, S., Polikarpova, N., Polyanskaya, T., Pospelov, I., Pospelova, E., Prokhorov, I., Prokosheva, I., Puchnina, L., Putrashyk, I., Raiskaya, J., Rozhkov, Y., Rozhkova, O., Rudenko, M., Rybnikova, I., Rykova, S., Sahnevich, M., Samoylov, A., Sanko, V., Sapelnikova, I., Sazonov, S., Selyunina, Z., Shalaeva, K., Shashkov, M., Shcherbakov, A., Shevchyk, V., Shubin, S., Shujskaja, E., Sibgatullin, R., Sikkila, N., Sitnikova, E., Sivkov, A., Skok, N., Skorokhodova, S., Smirnova, E., Sokolova, G., Sopin, V., Spasovski, Y., Stepanov, S., Stratiy, V.І., Strekalovskaya, V., Sukhov, A., Suleymanova, G., Sultangareeva, L., Teleganova, V., Teplov, V., Teplova, V., Tertitsa, T., Timoshkin, V., Tirski, D., Tolmachev, A., Tomilin, A., Tselishcheva, L., Turgunov, M., Tyukh, Y., Vladimir, V., Vargot, E., Vasin, A., Vasina, A., Vekliuk, A., Vetchinnikova, L., Vinogradov, V., Volodchenkov, N., Voloshina, I., Xoliqov, T., Yablonovska-Grishchenko, E., Yakovlev, V., Yakovleva, M., Yantser, O., Yarema, Y., Zahvatov, A., Zakharov, V., Zelenetskiy, N., Zheltukhin, A., Zubina, T., Kurhinen, J.

Published
2020
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8. The Y-Box Binding Protein 1 Suppresses Alzheimer's Disease Progression in Two Animal Models

Author

Olga G. Tatarnikova, A. A. Ustyugov, Natalia V. Bobkova, Sergey Guryanov, Michail S. Kukharsky, Irina Nesterova, Dmitry N. Polyakov, Lev P. Ovchinnikov, Irina Yu. Aleksandrova, Pavel Nekrasov, Dmitry A. Kretov, Alexei Samokhin, A. G. Bobylev, I. M. Vikhlyantsev, Dmitry N. Lyabin, N. I. Medvinskaya, and Irina A. Eliseeva

Subjects
Male, Transgene, Hippocampus, lcsh:Medicine, Mice, Inbred Strains, Mice, Transgenic, Plaque, Amyloid, Biology, Alzheimer Disease, medicine, Animals, Humans, Maze Learning, lcsh:Science, Cells, Cultured, Neurons, Amyloid beta-Peptides, Microscopy, Confocal, Multidisciplinary, Neocortex, Binding protein, lcsh:R, Neurotoxicity, Brain, Y box binding protein 1, medicine.disease, Immunohistochemistry, Olfactory Bulb, Molecular biology, Peptide Fragments, Recombinant Proteins, Rats, Olfactory bulb, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, Animals, Newborn, Disease Progression, Electrophoresis, Polyacrylamide Gel, lcsh:Q, Y-Box-Binding Protein 1, Alzheimer's disease, Research Article
Abstract

The Y-box binding protein 1 (YB-1) is a member of the family of DNA- and RNA binding proteins. It is involved in a wide variety of DNA/RNA-dependent events including cell proliferation and differentiation, stress response, and malignant cell transformation. Previously, YB-1 was detected in neurons of the neocortex and hippocampus, but its precise role in the brain remains undefined. Here we show that subchronic intranasal injections of recombinant YB-1, as well as its fragment YB-11-219, suppress impairment of spatial memory in olfactory bulbectomized (OBX) mice with Alzheimer's type degeneration and improve learning in transgenic 5XFAD mice used as a model of cerebral amyloidosis. YB-1-treated OBX and 5XFAD mice showed a decreased level of brain β-amyloid. In OBX animals, an improved morphological state of neurons was revealed in the neocortex and hippocampus; in 5XFAD mice, a delay in amyloid plaque progression was observed. Intranasally administered YB-1 penetrated into the brain and could enter neurons. In vitro co-incubation of YB-1 with monomeric β-amyloid (1-42) inhibited formation of β-amyloid fibrils, as confirmed by electron microscopy. This suggests that YB-1 interaction with β-amyloid prevents formation of filaments that are responsible for neurotoxicity and neuronal death. Our data are the first evidence for a potential therapeutic benefit of YB-1 for treatment of Alzheimer's disease.

Published
2015

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