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2. Comparison of survivals between sublobar resection and lobar resection for patients with clinical stage I non‐small cell lung cancer and interstitial lung disease: a propensity score matching analysis.

Author

Matsushima, Ryohei, Fujino, Kosuke, Motooka, Yamato, Yamada, Hiroyuki, Shirakami, Chika, Shinchi, Yusuke, Osumi, Hironobu, Yamada, Tatsuya, Yoshimoto, Kentaro, Ikeda, Koei, Kubota, Ichiro, and Suzuki, Makoto

Subjects
CANCER relapse, T-test (Statistics), THORACIC surgery, FISHER exact test, INTERSTITIAL lung diseases, TREATMENT effectiveness, RETROSPECTIVE studies, CHI-squared test, MANN Whitney U Test, MULTIVARIATE analysis, DESCRIPTIVE statistics, SURGICAL complications, KAPLAN-Meier estimator, LOG-rank test, MEDICAL records, ACQUISITION of data, LUNG tumors, STATISTICS, LUNG cancer, COMPARATIVE studies, DATA analysis software, OVERALL survival, PROPORTIONAL hazards models
Abstract

Background: Patients with early‐stage lung cancer and interstitial lung disease have a poorer prognosis than those without interstitial lung disease. This study aimed to compare the long‐term outcomes of lobar and sublobar resections in these patients. Methods: We retrospectively analyzed 138 consecutive patients with clinical stage I non‐small cell lung cancer and interstitial lung disease who underwent surgical treatment at two institutions between January 2010 and December 2020. Propensity score matching analysis was performed to adjust for baseline characteristics. Results: Thirty‐six patients underwent sublobar resection and 102 underwent lobar resection. The median follow‐up was 45.7 months. In all patients, 5‐year overall survival (OS) rates were 33.2% and 73.2%, and 5‐year recurrence‐free survival (RFS) rates were 24.2% and 60.1% in the sublobar and lobar resection groups, respectively (p < 0.01, <0.01). Death due to lung cancer and locoregional recurrence were significantly more frequent in the sublobar resection group than in the lobar resection group (p = 0.034, <0.01, respectively). On propensity score matching analysis, the 5‐year OS rates of the 19 matched pairs were 46.3% and 73.2%, and the RFS rates were 31.6% and 67.6% in the sublobar and lobar resection groups, respectively (p = 0.036, <0.01). The Cox proportional hazards model demonstrated a significant association between lobar resection and improved survival (p = 0.047). Conclusion: The patients in the lobar resection group had better survival rates than those in the sublobar resection group. In terms of long‐term prognosis, deliberately limited surgery may not be necessary for patients who tolerate lobectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Negative impact of ratio of the microvascular area to tumor area on the response to EGFR-TKI in non-small cell lung cancer with an EGFR mutation

Author

Anai, Moriyasu, primary, Saruwatari, Koichi, additional, Imamura, Kosuke, additional, Fujino, Kosuke, additional, Jodai, Takayuki, additional, Sakata, Shinya, additional, Iyama, Shinji, additional, Tomita, Yusuke, additional, Saeki, Sho, additional, Ichiyasu, Hidenori, additional, Ikeda, Koei, additional, Suzuki, Makoto, additional, and Sakagami, Takuro, additional

Published
2024
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8. Distinct functions between ferrous and ferric iron in lung cancer cell growth.

Author

Hinokuma, Hironori, Kanamori, Yohei, Ikeda, Koei, Hao, Li, Maruno, Masataka, Yamane, Taishi, Maeda, Ayato, Nita, Akihiro, Shimoda, Mayuko, Niimura, Mayumi, Takeshima, Yuki, Li, Shuran, Suzuki, Makoto, and Moroishi, Toshiro

Abstract

Accumulating evidence suggests an association between iron metabolism and lung cancer progression. In biological systems, iron is present in either reduced (Fe2+; ferrous) or oxidized (Fe3+; ferric) states. However, ferrous and ferric iron exhibit distinct chemical and biological properties, the role of ferrous and ferric iron in lung cancer cell growth has not been clearly distinguished. In this study, we manipulated the balance between cellular ferrous and ferric iron status by inducing gene mutations involving the FBXL5–IRP2 axis, a ubiquitin‐dependent regulatory system for cellular iron homeostasis, and determined its effects on lung cancer cell growth. FBXL5 depletion (ferrous iron accumulation) was found to suppress lung cancer cell growth, whereas IRP2 depletion (ferric iron accumulation) did not suppress such growth, suggesting that ferrous iron but not ferric iron plays a suppressive role in cell growth. Mechanistically, the depletion of FBXL5 impaired the degradation of the cyclin‐dependent kinase inhibitor, p27, resulting in a delay in the cell cycle at the G1/S phase. FBXL5 depletion in lung cancer cells also improved the survival of tumor‐bearing mice. Overall, this study highlights the important function of ferrous iron in cell cycle progression and lung cancer cell growth. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

Author

Imamura, Kosuke, primary, Tomita, Yusuke, additional, Sato, Ryo, additional, Ikeda, Tokunori, additional, Iyama, Shinji, additional, Jodai, Takayuki, additional, Takahashi, Misako, additional, Takaki, Akira, additional, Akaike, Kimitaka, additional, Hamada, Shohei, additional, Sakata, Shinya, additional, Saruwatari, Koichi, additional, Saeki, Sho, additional, Ikeda, Koei, additional, Suzuki, Makoto, additional, and Sakagami, Takuro, additional

Published
2022
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11. Clinical impact of SUVmax of interstitial lesions in lung cancer patients with interstitial lung disease who underwent pulmonary resection

Author

Akaike, Kimitaka, primary, Saruwatari, Koichi, additional, Matsushima, Ryohei, additional, Fujino, Kosuke, additional, Morinaga, Jun, additional, Oda, Seitaro, additional, Takahashi, Hiroshi, additional, Shiraishi, Shinya, additional, Okabayashi, Hiroko, additional, Hamada, Shohei, additional, Tomita, Yusuke, additional, Masunaga, Aiko, additional, Saeki, Sho, additional, Ikeda, Koei, additional, Ichiyasu, Hidenori, additional, Suzuki, Makoto, additional, and Sakagami, Takuro, additional

Published
2022
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12. SPP1 Derived from Macrophages Is Associated with a Worse Clinical Course and Chemo-Resistance in Lung Adenocarcinoma

Author

Matsubara, Eri, primary, Komohara, Yoshihiro, additional, Esumi, Shigeyuki, additional, Shinchi, Yusuke, additional, Ishizuka, Shiho, additional, Mito, Remi, additional, Pan, Cheng, additional, Yano, Hiromu, additional, Kobayashi, Daiki, additional, Fujiwara, Yukio, additional, Ikeda, Koei, additional, Sakagami, Takuro, additional, and Suzuki, Makoto, additional

Published
2022
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13. Classification of PD‐L1 expression in various cancers and macrophages based on immunohistocytological analysis

Author

Saito, Yoichi, primary, Fujiwara, Yukio, additional, Shinchi, Yusuke, additional, Mito, Remi, additional, Miura, Yuji, additional, Yamaguchi, Tomoya, additional, Ikeda, Koei, additional, Urakami, Shinji, additional, Nakashima, Yuta, additional, Sakagami, Takuro, additional, Suzuki, Makoto, additional, Tabata, Yasuhiko, additional, and Komohara, Yoshihiro, additional

Published
2022
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14. The Expression of PD-1 Ligand 1 on Macrophages and Its Clinical Impacts and Mechanisms in Lung Adenocarcinoma

Author

Shinchi, Yusuke, Komohara, Yoshihiro, Matsubara, Eri, Yonemitsu, Kimihiro, Yoshii, Daiki, Fujiwara, Yukio, Ikeda, Koei, Tamada, Koji, and Suzuki, Makoto

Subjects
allergology
Abstract

Background; Programmed death-1 (PD-1) and PD-1 ligand 1 (PD-L1) are target molecules for immunotherapy in non-small cell lung cancer. PD-L1 is expressed not only in cancer cells, but also on macrophages, and has been suggested to contribute to macrophage-mediated immune suppression. Methods; Clinical significance of PD-L1 expression on macrophages in human lung adenocarcinoma was examined. The mechanisms of PD-L1 overexpression on macrophages were investigated by means of cell culture studies. Results; High PD-L1 expression on macrophages was correlated with the presence of EGFR mutation, a lower cancer grade, and a shorter cancer-specific overall survival. In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate PD-L1 expression on macrophages via STAT3 activation, and a cytokine array revealed that granulocyte-macrophage colony-stimulating factor (GM-CSF) was a candidate factor that induced PD-L1 expression. Culture studies using recombinant GM-CSF, neutralizing antibody, and inhibitors indicated that PD-L1 overexpression was induced via STAT3 activation by GM-CSF derived from cancer cells. Conclusions; PD-L1 overexpression on macrophages via the GM-CSF/STAT3 pathway was suggested to promote cancer progression in lung adenocarcinoma. Cancer cell-derived GM-CSF might be a promising target for anti-cancer therapy.

Published
2021

30. Comparison of postoperative pulmonary function and air leakage between pleural closure vs. mesh-cover for intersegmental plane in segmentectomy

Author

Ohba Yasuomi, Mori Takeshi, Nomori Hiroaki, Yoshimoto Kentaro, Shiraishi Kenji, and Ikeda Koei

Subjects
Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background To prevent postoperative air leakage after lung segmentectomy, we used two methods for the intersegmental plane: closing it by suturing the pleural edge (pleural closure), or opening it with coverage using polyglycolic acid mesh and fibrin glue (mesh-cover). The preserved forced expiratory volume in one second (FEV1) of each lobe and the postoperative air leakage were compared between the two groups. Methods For 61 patients who underwent pleural closure and 36 patients who underwent mesh-cover, FEV1 of the lobe before and after segmentectomy was measured using lung-perfusion single-photon-emission computed tomography and CT (SPECT/CT). The groups' results were compared, revealing differences of the preserved FEV1 of the lobe for several segmentectomy procedures and postoperative duration of chest tube drainage. Results Although left upper division segmentectomy showed higher preserved FEV1 of the lobe in the mesh-cover group than in the pleural closure one (p = 0.06), the other segmentectomy procedures showed no differences between the groups. The durations of postoperative chest drainage in the two groups (2.0 ± 2.5 vs. 2.3 ± 2.2 days) were not different. Conclusions Mesh-cover preserved the pulmonary function of remaining segments better than the pleural closure method in left upper division segmentectomy, although no superiority was found in the other segmentectomy procedures. However, the data include no results obtained using a stapler, which cuts the segment without recognizing even the intersegmental plane and the intersegmental vein. Mesh-cover prevented postoperative air leakage as well as the pleural closure method did.

Published
2011
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31. Combined subsegmentectomy: postoperative pulmonary function compared to multiple segmental resection

Author

Ohba Yasuomi, Mori Takeshi, Nomori Hiroaki, Yoshimoto Kentaro, Shiraishi Kenji, and Ikeda Koei

Subjects
Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background For small peripheral c-T1N0M0 non-small cell lung cancers involving multiple segments, we have conducted a resection of subsegments belonging to different segments, i.e. combined subsegmentectomy (CSS), to avoid resection of multiple segments or lobectomy. Tumor size, location of tumor, and forced expiratory volume in 1 second (FEV1) of each preserved lobe were compared among the CSS, resection of single segment, and that of multiple segments. Methods FEV1 of each preserved lobe were examined in 17 patients who underwent CSS, 56 who underwent resection of single segment, and 41 who underwent resection of multiple segments, by measuring pulmonary function and lung-perfusion single-photon-emission computed tomography and computed tomography before and after surgery. Results Tumor size in the CSS was significantly smaller than that in the resection of multiple segments (1.4 ± 0.5 vs. 2.0 ± 0.8 cm, p = 0.002). Tumors in the CSS were located in the right upper lobe more frequently than those in the resection of multiple segments (53% vs. 5%, p < 0.001). Postoperative of FEV1 of each lobe after the CSS was higher than that after the resection of multiple segments (0.3 ± 0.2 vs. 0.2 ± 0.2 l, p = 0.07). Mean FEV1 of each preserved lobe per subsegment after CSS was significantly higher than that after resection of multiple segments (0.05 ± 0.03 vs. 0.03 ± 0.02 l, p = 0.02). There was no significant difference of these factors between the CSS and resection of single segment. Conclusions The CSS is effective for preserving pulmonary function of each lobe, especially for small sized lung cancer involving multiple segments in the right upper lobe, which has fewer segments than other lobes.

Published
2011
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48. Reply to the Editor

Author

Nomori, Hiroaki, primary, Ikeda, Koei, additional, Mori, Takeshi, additional, Kobayashi, Hironori, additional, Iwatani, Kazunori, additional, Kawanaka, Koichi, additional, Shiraishi, Shinya, additional, and Kobayashi, Toshiaki, additional

Published
2007
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