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Recurrent pregnancy loss (RPL) affects 1% to 5% of women, with devastating effects on both reproductive health and psychological well-being. Homeobox (

The ferroelectric field‐effect transistor (FeFET) is one of the leading contenders to succeed charge‐trap‐based flash memory (CTF) devices in the current vertically‐integrated NAND flash storage market. The operation of a FeFET is based on the field‐effect in the channel of the FET that is exerted by the uncompensated ferroelectric bound charge, which is also the fundamental source of the depolarization effect. This paper briefly reviews the current status of CTF‐based NAND flash memory as a benchmark for FeFET. Then, a one‐dimensional model based on a load‐line analysis of FeFET technology is presented. The paper subsequently deals with the two‐dimensional domain effect in nano‐sized NAND‐type FeFET devices. While NAND‐type FeFET operation is likely, current ferroelectric materials with high remanent polarization (Pr) of ∼10 μCcm‐2 and coercive field (Ec) of ∼1 MVcm‐1 are not feasible for use in such devices. This is fundamentally due to the high depolarization field induced by the unnecessarily high Pr, which not only destabilizes the memory state but also induces a severe interference effect between neighboring cells. Therefore, a new ferroelectric material with a moderately low Pr and higher Ec > ∼3 MVcm‐1 is necessary, along with structural innovation to minimize the interference effect.

Coronary artery disease (CAD), a leading cause of death worldwide, has a complex etiology comprising both traditional risk factors (type 2 diabetes, dyslipidemia, arterial hypertension, and cigarette smoking) and genetic factors. Vascular endothelial growth factor (VEGF) notably contributes to angiogenesis and endothelial homeostasis. However, little is known about the relationship between CAD and VEGF polymorphisms in Koreans. The aim of this study is to investigate the associations of 2 VEGF promoter region polymorphisms (−1154G>A [rs1570360], −1498T>C [rs833061]) and 4 VEGF 3′-UTR polymorphisms (+936C>T [rs3025039], +1451C>T [rs3025040], +1612G>A [rs10434], and +1725G>A [rs3025053]) with CAD susceptibility in Koreans. We studied 885 subjects: 463 CAD patients and 422 controls. Genotyping was conducted with polymerase chain reaction-restriction fragment length polymorphism analysis and TaqMan allelic discrimination assays, and the genotype frequencies were calculated. We then performed haplotype and genotype combination analyses and measured the associations between VEGF polymorphisms and clinical variables in both the CAD patients and control subjects. We detected statistically significant associations between CAD and certain VEGF allele combinations. In the haplotypes of 5 single-nucleotide polymorphisms, the VEGF allele combination −1154A/+936T was associated with a decreased prevalence of CAD (A-T-T-G-G of VEGF −1154G>A/−1498T>C/+936C>T/+1612G>A/+1725G>A, AOR = 0.077, p = 0.021). In contrast, the VEGF allele combinations −1498T/+1725A and −1498T/+1612A/+1725A were associated with an increased prevalence of CAD (G-T-C-C-A of VEGF −1154G>A/−1498T>C/+936C>T/+1451C>T/+1725G>A, AOR = 1.602, p = 0.047; T-C-C-A-A of VEGF −1498T>C/+936C>T/+1451C>T/+1612G>A/+1725G>A, AOR = 1.582, p = 0.045). Gene–environment combinatorial analysis showed that the combination of the VEGF +1725AA genotype and several clinical factors (e.g., body mass index, hemoglobin A1c, and low-density lipoprotein cholesterol) increased the risk of CAD. Therefore, we suggest that VEGF polymorphisms and clinical factors may impact CAD prevalence.

The chemical, physical, and electrical properties of the atomic layer deposited Hf0.5Zr0.5O2 thin films using tetrakis(ethylmethylamino) (TEMA) and tetrakis(dimethylamino) (TDMA) precursors are compared. The ligand of the metal-organic precursors strongly affects the residual C concentration, grain size, and the resulting ferroelectric properties. Depositing Hf0.5Zr0.5O2 films with the TDMA precursors results in lower C concentration and slightly larger grain size. These findings are beneficial to grow more ferroelectric-phase-dominant film, which mitigates its wake-up effect. From the wake-up test of the TDMA-Hf0.5Zr0.5O2 film with a 2.8 MV/cm cycling field, the adverse wake-up effect was well suppressed up to 105 cycles, with a reasonably high double remanent polarization value of ~40 μC/cm2. The film also showed reliable switching up to 109 cycles with the 2.5 MV/cm cycling field without involving the wake-up effect but with the typical fatigue behavior.

Atomic-resolution Cs-corrected scanning transmission electron microscopy revealed local shifting of two oxygen positions (O

Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses prior to 20 weeks of gestational age. Various factors, including immune dysfunction, endocrine disorders, coagulation abnormality, and genetic disorders influence RPL. In particular, plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), and renin (REN) have important roles in the thrombotic and thrombolytic systems, and abnormal expression of these genes have a reported negative correlation with pregnancy maintenance. Moreover, some polymorphisms of the three genes are related to expression levels and thrombotic disorder. Therefore, we investigated whether polymorphisms of PAI-1, tPA, and REN are linked to RPL. Genotyping of the six polymorphisms (PAI-1 rs11178, rs1050955, tPA rs4646972, rs2020918, REN rs1464816, and rs5707) was performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism and associations of the polymorphisms with RPL were evaluated by statistical analysis. The polymorphism PAI-1 rs1050955 GA+AA was associated with decreased RPL risk (AOR, 0.528; 95% CI 0.356–0.781; p = 0.001) as was the REN 10795 rs5707 GG genotype (AOR, 0.487; 95% CI 0.301–0.787; p = 0.003). In contrast, the tPA rs4646972 II genotype correlated with increased RPL risk (AOR, 1.606; 95% CI, 1.047–2.463; p = 0.030). This study provides evidence that tPA Alu rs4646972 may contribute to the risk of idiopathic RPL, but PAI-1 12068 rs1050955 and REN 10795 rs5707 are associated with a decreased risk of RPL. Therefore, these alleles may be useful as biomarkers to evaluate the risk of RPL.

The effect of soaking temperature on the moisture uptake and the protein loss of soybeans during soaking process investigated. As the soaking temperature increased, the soaking rate significantly increased and Peleg model was suitable for describing the soaking characteristics of the soybean with high R2 values (>0.991). The soaking time to achieve the target moisture content of soybean (130%) was estimated to be 12.6, 3.11 and 2.31 h at 25, 35 and 45 ℃, respectively. Peleg model well described the protein loss kinetics of soybean during soaking with high R2 values (>0.941). The results showed that the protein loss of soybean at the target moisture content were 35.2, 93.1 and 103.0 mg/g at 25, 35 and 45 ℃, respectively. In this study, the optimum soaking condition for quality of soybean was 12.6 h of soaking time at 25 ℃.

Recurrent implantation failure (RIF) refers to the occurrence of more than two failed in vitro fertilization–embryo transfers (IVF-ETs) in the same individual. RIF can occur for many reasons, including embryo characteristics, immunological factors, and coagulation factors. Genetics can also contribute to RIF, with some single-nucleotide variants (SNVs) reported to be associated with RIF occurrence. We examined SNVs in a long non-coding RNA, homeobox (HOX) transcript antisense RNA (HOTAIR), which is known to affect cancer development. HOTAIR regulates epigenetic outcomes through histone modifications and chromatin remodeling. We recruited 155 female RIF patients and 330 healthy controls, and genotyped HOTAIR SNVs, including rs4759314, rs920778, rs7958904, and rs1899663, in all participants. Differences in these SNVs were compared between the patient and control groups. We identified significant differences in the occurrence of heterozygous genotypes and the dominant expression model for the rs1899663 and rs7958904 SNVs between RIF patients and control subjects. These HOTAIR variants were associated with serum hemoglobin (Hgb), luteinizing hormone (LH), total cholesterol (T. chol), and blood urea nitrogen (BUN) levels, as assessed by analysis of variance (ANOVA). We analyzed the four HOTAIR SNVs and found significant differences in haplotype patterns between RIF patients and healthy controls. The results of this study showed that HOTAIR is not only associated with the development of cancer but also with pregnancy-associated diseases. This study represents the first report showing that HOTAIR is correlated with RIF.

The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identified using WES screening. Possible associations between the five gene polymorphisms and CAD susceptibility were examined in 452 CAD patients and 421 control subjects. Multivariate logistic regression analyses indicated that the CUBN rs2291521GA and HNF1A rs55783344CT genotypes were associated with CAD (GG vs. GA; adjusted odds ratio [AOR] = 1.530; 95% confidence interval [CI] 1.113–2.103; P = 0.002 and CC vs. CT; AOR = 1.512; 95% CI 1.119–2.045; P = 0.007, respectively). The CUBN rs2291521GA and HNF1A rs55783344CT genotype combinations exhibited a stronger association with CAD risk (AOR = 2.622; 95% CI 1.518–4.526; P = 0.001). Gene-environment combinatorial analyses indicated that the CUBN rs2291521GA, HNF1A rs55783344CT, and LIPC rs17269397AA genotype combination and several clinical factors (fasting blood sugar (FBS), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels) were associated with increased CAD risk. The CUBN rs2291521GA, HNF1A rs55783344CT, and LIPC rs17269397AA genotypes in conjunction with abnormally elevated cholesterol levels increase the risk of developing CAD. This exploratory study suggests that polymorphisms in the CUBN, HNF1A, and LIPC genes can be useful biomarkers for CAD diagnosis and treatment.

Moisture transfer characteristics of Alaska pollock (AP) surimi were investigated at various temperatures. The effective moisture diffusivity increased from 5.50 &times, 10&minus, 11 to 2.07 &times, 9 m2/s as the temperature increased from 30 &deg, C to 90 &deg, C. In order to investigate the mass and heat transfer characteristics of AP surimi, the simulation model was developed and evaluated by root-mean-square error (RMSE) (&lt, 2.95%). Rheological properties of AP surimi were investigated at different heating rates (1 &deg, C/min, 5 &deg, C/min, 10 &deg, C/min, 20 &deg, C/min and 30 &deg, C/min). As heating rate increased to 20 &deg, C/min, elastic modulus (G&rsquo, ) significantly diminished. The diminished G&rsquo, could be explained by impaired gel during temperature sweep supported by the predicted temperature distribution in the simulation model. Changes in moisture content of AP surimi during temperature sweep were also measured and predicted by the simulation model. The results showed the decreased amount of moisture content significantly increased as heating rate increased.

The objective of this study was to investigate the inactivation kinetics of Enterococcus faecium in peanut butter under different water activities (aw) and superheated steam temperatures. Peanut butters were prepared at 4 different initial water activities (0.19, 0.40, 0.60, and 0.80) and E. faecium was inoculated into the peanut butter (7.4–8.7 log CFU/g). The inoculated peanut butter samples were exposed at 4 different superheated steam temperatures (125 °C, 175 °C, 225 °C, and 250 °C). Survivor data were modelled using Weibull and log-linear models to describe the inactivation kinetics of E. faecium. The decimal reduction times (D-value), temperature sensitivity (zT) and aw sensitivity (zaw) of the D-value were determined from a log-linear model, and inactivation parameters from the Weibull model were also evaluated. An increase in aw of peanut butter and superheated steam temperature decreased the D-value of E. faecium. The zaw-value and zT-value were determined to be 0.60 ± 0.09 and 194.66 ± 40.69 °C, respectively (R2 > 0.89). The inactivation kinetics of E. faecium on surfaces contaminated with peanut butter can provide comprehensive information to superheated steam sanitation treatment which may be applied to environmental surfaces for effective microbial inactivation without the introduction of water.

Understanding the inactivation kinetics of bacterial spores during combined pressure-thermal processing is essential for process design. The knowledge on the influence of pH and water activity (aw) during combined pressure-thermal treatment is limited. Experiments were conducted using Bacillus cereus spores suspended in citrate-phosphate buffers, adjusted to different levels of pH (3.8–7.3) and aw (0.80–0.99). Spores were then treated with a pressure-heat combination (600 MPa, 70 °C) using a laboratory-scale high-pressure kinetic tester. Linear regression and Weibull models were used to fit the experimental data. The kinetic parameters of the spores inactivation estimated from the models were plotted as a function of pH and aw. Results showed that the inactivation kinetic curves were characterized by tailing, particularly at low aw levels. The log reduction of B. cereus spores decreased with the decrease of aw. During pressure-thermal treatment, the changes in acidity values for a given water activity have limited influence on decimal reduction values of the spores. Study findings will be helpful for designing pressure-thermal processes to produce microbially safe products with varying water activity and acidity levels.

The mouthfeel of mashed potato prepared with steamed purple flesh potato (SPFP) was investigated by measuring tribological and rheological characteristics. Mathematical models describing pre-processes such as drying and grinding associated with physical properties of mashed potato were also explored. The effect of drying temperature (60, 70, 80, and 90°C) on quality changes (moisture and anthocyanin content) of SPFP was successfully described (R2 > 0.9583). The sigmoid model was suitably applied to estimate particle sizes of dried SPFP during grinding (R2 > 0.9864). As the particle size of mashed SPFP increased, friction coefficient increased, and storage and loss modulus decreased. Taste, smoothness, and after-feel sensation were increased as particle sizes decreased, while appearance and odor showed no significant differences. To predict the sensory property using tribology and rheology, the specific conditions were successfully determined (R2 > 0.9926). A partir de la medición de las características tribológicas y reológicas se investigó la sensación producida en la boca por el puré de papas preparado con pulpa de papa morada al vapor (PPMV). Asimismo, se examinaron modelos matemáticos que describen procesos previos, como el secado y la trituración, asociados con las propiedades físicas del puré de papa. Se registró correctamente el efecto que distintas temperaturas de secado (60, 70, 80 y 90°C) tienen en los cambios de calidad (contenido de humedad y de antocianina) de la PPMV (R2 > 0,9583). Además, el modelo sigmoidal se aplicó de manera adecuada a fin de estimar el tamaño de las partículas de PPMV secadas durante la trituración (R2 > 0,9864). Se constató que cuando el tamaño de la partícula de PPMV era mayor se elevó el coeficiente de fricción y disminuyeron los módulos de almacenamiento y de pérdida. El sabor, la suavidad y la sensación posterior se incrementaron a medida que el tamaño de las partículas fue disminuyendo, mientras que la apariencia y el aroma no presentaron diferencias significativas. Se determinaron correctamente las condiciones específicas para pronosticar las propiedades sensoriales utilizando tribología y reología (R2 > 0,9926).

The chemical, physical, and electrical properties of the atomic layer deposited Hf0.5Zr0.5O2 thin films using tetrakis(ethylmethylamino) (TEMA) and tetrakis(dimethylamino) (TDMA) precursors are compared. The ligand of the metal-organic precursors strongly affects the residual C concentration, grain size, and the resulting ferroelectric properties. Depositing Hf0.5Zr0.5O2 films with the TDMA precursors results in lower C concentration and slightly larger grain size. These findings are beneficial to grow more ferroelectric-phase-dominant film, which mitigates its wake-up effect. From the wake-up test of the TDMA-Hf0.5Zr0.5O2 film with a 2.8 MV/cm cycling field, the adverse wake-up effect was well suppressed up to 105 cycles, with a reasonably high double remanent polarization value of ~40 μC/cm2. The film also showed reliable switching up to 109 cycles with the 2.5 MV/cm cycling field without involving the wake-up effect but with the typical fatigue behavior.

The aim of this study was to investigate the effect of water activity (aw) on inactivation of Listeria monocytogenes using gaseous chlorine dioxide (ClO2 (g)) under room temperature. Surface-inoculated tryptic soy agar (TSA) plates adjusted to 9 different water activity levels ranging from 0.994 to 0.429 were used as samples exposed to ClO2 (g) at 150, 250, and 350 ppm for different durations of treatment time. Results showed that the antimicrobial effect of ClO2 (g) significantly decreases as the aw level and ClO2 (g) concentration decrease. Nonlinear models, such as the modified Chick model and the Weibull model, were used to describe the inactivation kinetics of L. monocytogenes. The results showed that the modified Chick model, which is based on chemical reaction kinetics, was more suitable to describe the inactivation of L. monocytogenes (RMSE

In the past, the domestic construction industry mainly comprised quantitative investment through the supply of labor force, however, there have recently been opinions that there is a need for qualitative investment in the workers in order to obtain competitiveness in construction markets. Accordingly, there are much re-education courses for workers in the construction industry, but there is much negative awareness as to the efficiency of the current re-education course due to many problems. This study aimed to examine the problems o f currently executed re-education courses and proposed an improvement plan for the qualitative enhancement of domestic construction re-education. Thus, a multiple regression analysis was conducted to deduce two core problems an improvement plan. The improvement plan for the problems comprised the NCS/CDP-based integrative education program through an AHP. The contribution of this paper will result in the execution of a more effective construction industry re-education program, and the result of such program to achieve qualitative growth in the workers in the construction industry

A recent study of the ischemic stroke described the roles played by miRNAs in the downregulation of specific cell-cycle gene expression and it is thought to require the development of biomarkers for the prognostic of ischemic stroke. Here, we hypothesized that four miRNA polymorphisms (miR-10a, miR-27a, miR-34b/c, and miR-300) may affect stroke susceptibility and mortality. Blood samples were collected from 530 patients and 403 controls. Genetic polymorphisms were detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and real-time PCR. We found that the miR-300 rs12894467 TC genotype and the dominant model (AOR: 2.069, p-value: 0.017, AOR: 1.931, p-value: 0.027) were significantly associated with an increased risk for the ischemic stroke subtype. In Cox proportional hazard regression models, the miR-10a rs3809783 A&gt, T and miR-34b/c rs4938723 T&gt, C polymorphisms were associated with the mortality rates among ischemic stroke patients. We found that a miR-300 polymorphism was associated with increased ischemic stroke susceptibility among the Korean population. Additionally, polymorphisms in miR-10a and miR-34b/c were associated with the increased or decreased mortality of ischemic stroke patients. This study marks the first report of an association between ischemic stroke and miRNA polymorphisms (miR-10aA&gt, T, miR-27aT&gt, C, miR-34b/cT&gt, C, and miR-300T&gt, C) in the Korean population.

Computational fluid dynamics (CFD) is a powerful tool to model fluid flow motions for momentum, mass and energy transfer. CFD has been widely used to simulate the flow pattern and temperature distribution during the thermal processing of foods. This paper discusses the background of the thermal processing of food, and the fundamentals in developing CFD models. The constitution of simulation models is provided to enable the design of effective and efficient CFD modeling. An overview of the current CFD modeling studies of thermal processing in solid, liquid, and liquid-solid mixtures is also provided. Some limitations and unrealistic assumptions faced by CFD modelers are also discussed.

The warship is run based on the combat system which shares tactical information collected by target detection systems and navigation devices across a network, and conducts the command and control of weapons from target detection to kill assessment. The short-range air defense missile system defends a warship from anti-ship missiles, aircraft, helicopter and other threats in order to contribute to the survival of a warship and the success of missions. The short-range air defense missile system is applied to a various combat systems. In this paper, we have proposed the interface design between the short-range air defense missile and dissimilar combat systems. To employ the short-range air defense missile at dissimilar combat systems, each system is driven by independent processor, and the tasks which are performed by each system are assigned. The information created by them is exchanged through the interface, and the flow of messages is designed.Key Words : Dissimilar Combat Systems(이기종 함정 전투체계), Short-Range Air Defense Missile System(단거리 대공방어유도탄체계), Interface(연동), Flow of Messages(메시지 흐름)

This study investigated the factors that influence subjective well-being of immigrant wives in Korea. We initially grouped the factors into 3 categories: personal, domestic, and social. For personal factors, we included couple`s age difference, reason for entry, religion, marital duration, employment status, economical status, acculturation to Korean culture, acquisition of Korean language, and ego-resiliency. For domestic factors we included marriage process, reason for marriage, husbands` understanding of wife`s native language, husbands` understanding of wife`s culture, marital satisfaction, existence of children, head of the household, and parenting efficacy. Finally for social factors, awareness of welfare services and systems, use of public institutions and civil organizations, and participation in social groups were included. We recruited 256 immigrant wives who live in Asan City, Chungnam Province and the data were analyzed by multiple linear regression. The factors that statistically significant were: ego-resiliency, marital duration, acculturation to Korean culture and economic status among personal factors; parenting efficacy, marital satisfaction and marriage process (married without a matchmaker) among domestic factors; participation in self-help group of women from the same mother country, awareness of welfare services and systems, participation in hobby club, and participation in fraternal/religious society among social factors. It is hoped that this paper will yield general insights into subjective well-being of immigrant wives and may help them to develop inner talent and strength.

Cyclopolymerisation of 1,6-heptadiyne derivatives by Grubbs catalysts gives the conjugated polymers containing a five-membered ring repeat unit. The first example of cyclopolymerisation of 1,7-octadiyne derivatives is demonstrated here to give a new class of conjugated polymer that contains six-memebered rings. This polymerisation was very challenging and efficient cyclopolymerisation was achieved only with monomers that showed a significant Thorpe–Ingold effect. By using a third-generation Grubbs catalyst, we obtained the polymers with excellent molecular weight control and narrow PDIs. This controlled polymerisation allowed the synthesis of diblock copolymers containing five- and six-membered rings, respectively, from 1,6-heptadiyne and the 1,7-octadiyne derivatives.

Time domain electric pulse measurements were conducted on a capacitor consisting of a Pt film as the top electrode, atomic-layer-deposited 6.5-nm-thick amorphous Al2O3 as the dielectric layer, and two-dimensional electron gas (2DEG) at the interface between Al2O3 and SrTiO3 as the bottom electrode. The sample showed highly useful current-voltage characteristics as the selector in cross-bar array resistance switching random access memory. The long-term (order of second) variation in the leakage current when the Pt electrode was positively biased was attributed to the field-induced migration of oxygen vacancies between the interior of the Al2O3 and the 2DEG region. Relaxation of the vacancy concentration occurred even at room temperature.

Given relatively prime integers $a_1, \dotsc, a_n$, the Frobenius number $g(a_1, \dotsc, a_n)$ is defined as the largest integer which cannot be expressed as $x_1 a_1 + \dotsb + x_n a_n$ with $x_i$ nonnegative integers. In this article, we give the Frobenius number of primitive Pythagorean triples. That is, \[ g(m^2-n^2, 2mn, m^2+n^2) = (m-1)(m^2-n^2) + (m-1)(2mn) - (m^2 + n^2). \], 6 papges

Isopropryl 2-(1-3-dithiethane-2-ylidene)-2[N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439) is currently under phase II clinical trials by the Yuhan Research Center for use as a hepatoprotective agent. Unfortunately, the oral bioavailbility of YH439, which is sparingly soluble in water (i.e., 0.3μg/ml or 0.91μM at room temperature), reportedly, is negligible regardless of the dose administered to rats in the 10-300 mg/kg range. The bioavailability of the compound increased up to 24%, when administered in the form of a micellar solution (700 μg/ml or 2.1 mM for YH439) at a dose of 10 mg/kg, suggesting that its limited solubility is associated with its negligible bioavailability. In order to obtain additional information concerning the bioavailability of YH439, the mechanism(s) involved in gastrointestinal (GI) absorption were investigated in the present study. For this purpose, the transport of YH430 across a Caco-2 cell monolayer was measured in a Transwell(r). A permeability of 4.07×10-5 cm/s was obtained for the absorptive (i.e., apical to basolateral direction) transport of 0.42 μM YH439, implicating that the in vivo GI absorption is nearly complete. The absorptive transport exhibited a slight concentration-dependency with an intrinsic clearance (CLi) of 0.38 μL/cm2/sec, which accounted for 28.1% of the total intrinsic clearance (i.e., CLi plus the intrinsic clearance for the linear component) of the transport. Thus, saturation of the absorption process appears to be a minor factor in limiting the bioavailability of the compound. The apparent permeability of YH439 from the basolateral to the apical direction (i.e., efflux, 6.67×10-5 cm/s) was comparable to that for absorptive transport, but, interestingly, a more distinct concentration-dependency was observed for this transport. However, the efflux does not appear to influence the bioavailability of the compound, as evidenced by the sufficiently high permeability in the absorption direction. Rather, a reportedly extensive first-pass hepatic metabolism appears to be a principal factor in limiting the bioavailability. In this respect, reducing the first-pass metabolism by some means would lead to a higher bioavailability of the compound. Thus, elevation of the absorption rate of YH439 becomes a necessity. From a practical point of view, increasing the concentration of YH439 in the GI fluid appears to be a feasible way to increase the absorption rate, because the compound is primarily absorbed via a linear mechanism. In summary, the solubilization of YH439, as previously demonstrated for a micellar solution of the compound, appears to be a practical way to increase the oral bioavailability of YH439.