1. Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor
- Author
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Carlos Fontes Ribeiro, Eric Grouzmann, Daniela Grand, Maria Dulce Cotrim, Cláudia Cavadas, Hans R. Brunner, and François Mosimann
- Subjects
medicine.medical_specialty ,endocrine system ,Epinephrine ,Physiology ,Chromaffin Cells ,Clinical Biochemistry ,Human adrenal chromaffin cells ,AT2 receptor ,Biochemistry ,Receptor, Angiotensin, Type 1 ,Norepinephrine ,Cellular and Molecular Neuroscience ,Endocrinology ,Catecholamines ,Internal medicine ,Adrenal Glands ,Renin–angiotensin system ,medicine ,Humans ,Neuropeptide Y ,Cells, Cultured ,Angiotensin II receptor type 1 ,Chemistry ,AT1 receptor ,Angiotensin II ,Neuropeptide Y receptor ,medicine.anatomical_structure ,Chromaffin cell ,Catecholamine ,cardiovascular system ,Calcium ,Adrenal medulla ,Angiotensin II Type 1 Receptor Blockers ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction ,medicine.drug - Abstract
The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the receptor-AT2 agonist, T2-(Ang II 4-8)2 has no effect on NE, EP and NPY release from chromaffin cells. We further showed that Ang II increases intracellular Ca2+ concentration ([Ca2+]i). The selective AT1-receptor antagonist Candesartan blocked [Ca2+]i increase by Ang II, while T2-(Ang II 4-8)2 was ineffective. These findings demonstrate that AT1 stimulation induces catecholamine secretion from human adrenal chromaffin cells probably by raising cytosolic calcium. http://www.sciencedirect.com/science/article/B6T0S-478J1GP-4/1/703d0edba8be6689cfd19851f6d304e7
- Published
- 2003