15 results on '"Huaying Ren"'
Search Results
2. Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array
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Dehui Zhang, Dong Xu, Yuhang Li, Yi Luo, Jingtian Hu, Jingxuan Zhou, Yucheng Zhang, Boxuan Zhou, Peiqi Wang, Xurong Li, Bijie Bai, Huaying Ren, Laiyuan Wang, Ao Zhang, Mona Jarrahi, Yu Huang, Aydogan Ozcan, and Xiangfeng Duan
- Subjects
Science - Abstract
Abstract Nonlinear optical processing of ambient natural light is highly desired for computational imaging and sensing. Strong optical nonlinear response under weak broadband incoherent light is essential for this purpose. By merging 2D transparent phototransistors (TPTs) with liquid crystal (LC) modulators, we create an optoelectronic neuron array that allows self-amplitude modulation of spatially incoherent light, achieving a large nonlinear contrast over a broad spectrum at orders-of-magnitude lower intensity than achievable in most optical nonlinear materials. We fabricated a 10,000-pixel array of optoelectronic neurons, and experimentally demonstrated an intelligent imaging system that instantly attenuates intense glares while retaining the weaker-intensity objects captured by a cellphone camera. This intelligent glare-reduction is important for various imaging applications, including autonomous driving, machine vision, and security cameras. The rapid nonlinear processing of incoherent broadband light might also find applications in optical computing, where nonlinear activation functions for ambient light conditions are highly sought.
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- 2024
- Full Text
- View/download PDF
3. Interaction between microorganisms and dental material surfaces: general concepts and research progress
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Yan Tu, Huaying Ren, Yiwen He, Jiaqi Ying, and Yadong Chen
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Bacterial adhesion ,dental materials ,surface properties ,biological contamination ,intelligent dental material surfaces ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
ABSTRACTBacterial adhesion to dental materials’ surfaces is the initial cause of dental materials-related infections. Therefore, inhibiting bacterial adhesion is a critical step in preventing and controlling these infections. To this end, it is important to know how the properties of dental materials affect the interactions between microorganisms and material surfaces to produce materials without biological contamination. This manuscript reviews the mechanism of bacterial adhesion to dental materials, the relationships between their surface properties and bacterial adhesion, and the impact of bacterial adhesion on their surface properties. In addition, this paper summarizes how these surface properties impact oral biofilm formation and proposes designing intelligent dental material surfaces that can reduce biological contamination.
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- 2023
- Full Text
- View/download PDF
4. The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process
- Author
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Lian Li, Baoyang Ding, Qi Yang, Shang Chen, Huaying Ren, Jinfeng Wang, Hengchang Zang, Fengshan Wang, and Lixuan Zang
- Subjects
Chondroitin sulfate ,near infrared spectroscopy ,variable selection ,pathlength ,Technology ,Optics. Light ,QC350-467 - Abstract
Near infrared spectroscopy (NIRS) is based on molecular overtone and combination vibrations. It is difficult to assign specific features under complicated system. So it is necessary to find the relevance between NIRS and target compound. For this purpose, the chondroitin sulfate (CS) ethanol precipitation process was selected as the research model, and 90 samples of 5 different batches were collected and the content of CS was determined by modified carbazole method. The relevance between NIRS and CS was studied throughout optical pathlength, pretreatment methods and variables selection methods. In conclusion, the first derivative with Savitzky–Golay (SG) smoothing was selected as the best pretreatment, and the best spectral region was selected using interval partial least squares (iPLS) method under 1 mm optical cell. A multivariate calibration model was established using PLS algorithm for determining the content of CS, and the root mean square error of prediction (RMSEP) is 3.934 g⋅L-1. This method will have great potential in process analytical technology in the future.
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- 2014
- Full Text
- View/download PDF
5. Technology roadmap for flexible sensors
- Author
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Yifei Luo, Mohammad Reza Abidian, Jong-Hyun Ahn, Deji Akinwande, Anne M. Andrews, Markus Antonietti, Zhenan Bao, Magnus Berggren, Christopher A. Berkey, Christopher John Bettinger, Jun Chen, Peng Chen, Wenlong Cheng, Xu Cheng, Seon-Jin Choi, Alex Chortos, Canan Dagdeviren, Reinhold H. Dauskardt, Chong-an Di, Michael D. Dickey, Xiangfeng Duan, Antonio Facchetti, Zhiyong Fan, Yin Fang, Jianyou Feng, Xue Feng, Huajian Gao, Wei Gao, Xiwen Gong, Chuan Fei Guo, Xiaojun Guo, Martin C. Hartel, Zihan He, John S. Ho, Youfan Hu, Qiyao Huang, Yu Huang, Fengwei Huo, Muhammad M. Hussain, Ali Javey, Unyong Jeong, Chen Jiang, Xingyu Jiang, Jiheong Kang, Daniil Karnaushenko, Ali Khademhosseini, Dae-Hyeong Kim, Il-Doo Kim, Dmitry Kireev, Lingxuan Kong, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Lee, Fengyu Li, Jinxing Li, Cuiyuan Liang, Chwee Teck Lim, Yuanjing Lin, Darren J. Lipomi, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Liu, Xian Jun Loh, Nanshu Lu, Zhisheng Lv, Shlomo Magdassi, George G. Malliaras, Naoji Matsuhisa, Arokia Nathan, Simiao Niu, Jieming Pan, Changhyun Pang, Qibing Pei, Huisheng Peng, Dianpeng Qi, Huaying Ren, John A. Rogers, Aaron Rowe, Oliver G. Schmidt, Tsuyoshi Sekitani, Dae-Gyo Seo, Guozhen Shen, Xing Sheng, Qiongfeng Shi, Takao Someya, Yanlin Song, Eleni Stavrinidou, Meng Su, Xuemei Sun, Kuniharu Takei, Xiao-Ming Tao, Benjamin C. K. Tee, Aaron Voon-Yew Thean, Tran Quang Trung, Changjin Wan, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Wang, Paul S. Weiss, Hanqi Wen, Sheng Xu, Tailin Xu, Hongping Yan, Xuzhou Yan, Hui Yang, Le Yang, Shuaijian Yang, Lan Yin, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Yu, Evgeny Zamburg, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhang, Siyuan Zhao, Xuanhe Zhao, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zheng, Tao Zhou, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zhu, Guijin Zou, Xiaodong Chen, School of Materials Science and Engineering, School of Mechanical and Aerospace Engineering, School of Electrical and Electronic Engineering, School of Chemistry, Chemical Engineering and Biotechnology, Institute of Materials Research and Engineering, A*STAR, Institute of High Performance Computing, A*STAR, Singapore-HUJ Alliance for Research and Enterprise (SHARE), Innovative Center for Flexible Devices (iFLEX), Institute for Digital Molecular Analytics and Science (IDMxS), and Center for Integrated Circuits and Systems
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Materials [Engineering] ,Soft Materials ,Mechanics Engineering ,General Engineering ,General Physics and Astronomy ,General Materials Science - Abstract
Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version Y.L., Z.L., M.Z., and X.C. acknowledge the National Research Foundation, Singapore (NRF) under NRF’s Medium Sized Centre: Singapore Hybrid-Integrated Next-Generation μElectronics (SHINE) Centre funding programme, and AME programming funding scheme of Cyber Physiochemical Interface (CPI) project (no. A18A1b0045). Y.L. acknowledges National Natural Science Foundation of China (62201243). C.J. acknowledges funding support from the National Key R&D Program of China (no. 2019YFA0706100), the National Natural Science Foundation of China (82151305), Lingang Laboratory (LG-QS-202202-09). T.Q.T. and N.E.L. acknowledge support by the Basic Science Research Program (no. 2020R1A2C3013480) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT. A.F. acknowledges the AFOSR (grant FA9550-22-1-0423). Y.L. and Y.Z. would like to acknowledge the NSF (award no. 2134664) and NIH (award no. R01HD108473) for financial support. X.F. acknowledges the support from the National Natural Science Foundation of China (grant no. U20A6001). L.Y. would like to thank the A*STAR Central Research Fund (CRF) and the AME Programmatic A18A1b0045 (Cyber Physiochemical Interfaces) for funding support. C.F.G. acknowledges the National Natural Science Foundation of China (no. T2225017). T.Q.T. acknowledges the Brain Pool Program (No. 2020H1D3A2A02111068) through the National Research Foundation (NRF) funded by the Ministry of Science. Z.L. acknowledges the support from RIE2020 AME Programmatic Grant funded by A*STAR-SERC, Singapore (Grant No. A18A1b0045). X.G. acknowledges funding support through the Shanghai Science and Technology Commission (grant no. 19JC1412400), the National Science Fund for Excellent Young Scholars (grant no. 61922057). C.D. acknowledges National Science Foundation CAREER: Conformable Piezoelectrics for Soft Tissue Imaging (grant no. 2044688) and MIT Media Lab Consortium funding. D.K. and O.G.S. acknowledge Leibniz Association and the German Research Foundation DFG (Gottfried Wilhelm Leibniz Program SCHM 1298/22-1, KA5051/1-1 and KA 5051/3-1), as well as the Leibniz association (Leibniz Transfer Program T62/2019). C.W. acknowledges the National Key Research and Development Program of China (grant no. 2021YFA1202600), National Natural Science Foundation of China (grant no. 62174082). A.V.-Y.T., E.Z., Y.Z., X.Z., and J.P. acknowledge the National Research Foundation, Singapore (NRF) under NRF’s Medium Sized Centre: Singapore Hybrid-Integrated Next-Generation μElectronics (SHINE) Centre funding programme, and AME programming funding scheme of Cyber Physiochemical Interface (CPI) project (no. A18A1b0045). R.Z. acknowledges National Natural Science Foundation of China (grant no. 51735007) and Beijing Natural Science Foundation (grant no. 3191001). N.M. acknowledges the support by JST PRESTO Grant Number JPMJPR20B7 and JST Adaptable and Seamless Technology transfer Program through Target-driven R&D (ASTEP) grant number JPMJTM22BK. C.P. acknowledges the Korean government (Ministry of Science and ICT, MSIT) (2022R1A4A3032923). M.W. acknowledges the National Key R&D Program of China under Grant (2021YFB3601200). X.Z. acknowledges National Natural Science Foundation of China (no. 62074029). S.X. acknowledges the 3M nontenured faculty award. T.-W.L. and D.-G.S. acknowledge the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (grant no. NRF-2022M3C1A3081211). C.T.L. would like to acknowledge support from the Institute for Health Innovation and Technology (iHealthtech), the MechanoBioEngineering Laboratory at the Department of Biomedical Engineering and the Institute for Functional Intelligent Materials (I-FIM) at the National University of Singapore (NUS). C.T.L. also acknowledges support from the National Research Foundation and A*STAR, under its RIE2020 Industry Alignment Fund − Industry Collaboration Projects (IAF-ICP) (grant no. I2001E0059) − SIA-NUS Digital Aviation Corp Lab and the NUS ARTIC Research (grant no. HFM-RP1). X.Y. acknowledges funding support by City University of Hong Kong (grant no. 9667221). T.X. and X.Z. acknowledge National Natural Science Foundation of China (22234006). B.C.K.T. acknowledges Cyber-Physiochemical Interfaces CPI, A*STAR A18A1b0045. H.G. acknowledges a research start-up grant (002479-00001) from Nanyang Technological University and the Agency for Science, Technology and Research (A*STAR) in Singapore. W.G. acknowledges National Science Foundation grant 2145802. D.J.L. acknowledges support from the US National Science Foundation grant number CBET-2223566. G.Y. acknowledges support from The Welch Foundation award F-1861, and Camille Dreyfus Teacher-Scholar Award. M.D.D. acknowledges funding support from NSF (grant no. EEC1160483). J.-H.A acknowledges the National Research Foundation of Korea (NRF-2015R1A3A2066337). J.C. acknowledges the Henry Samueli School of Engineering & Applied Science and the Department of Bioengineering at the University of California, Los Angeles for startup support and a Brain & Behavior Research Foundation Young Investigator Grant. K.T. acknowledges JST AIP Accelerated Program (no. JPMJCR21U1) and JSPS KAKENHI (grant no. JP22H00594). P.S.W. acknowledges the National Science Foundation (CMMI1636136) for support. A.M.A., M.C.H., and P.S.W. thank the National Institute on Drug Abuse (DA045550) for support. S.M. and X.C. appreciated the support from the Smart Grippers for Soft Robotics (SGSR) Programme under the National Research Foundation, Prime Minister’s Office, Singapore under its Campus of Research Excellence and Technological Enterprise (CREATE) programme.
- Published
- 2023
6. The risk of Sjogren’s syndrome on immune checkpoint inhibitors:a retrospective pharmacovigilance study in FAERS database
- Author
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Siyuan Gao, Huaying Ren, Zhichao He, Jie Wu, Mengting Chen, Jianhong Zhu, Dan Liang, Wei Jiang, Shan Yang, Xiaoxia Yu, Min Huang, and Junyan Wu
- Abstract
Purpose Immune checkpoint inhibitors (ICIs) have favorable anti-tumor effects but can cause severe autoimmune toxicities. The number of cases of previous studies about the risk of Sjogren's syndrome (SS) induced by ICIs is low. This pharmacovigilance study is to reassess the relationship between SS and ICIs in the FDA Adverse Event Reporting System (FAERS). Methods Case reports of SS after ICIs were extracted from 2013 Q1 to 2020 Q4 in FAERS. the clinical features of the cases were described. The disproportionality analysis, reporting odds ratio (ROR) and information component (IC), was used to estimate the correlation between SS and ICIs. The clinical features of ICI-SS were described. Results In total, 160 cases of ICI-related SS were screened out. The median age was 63.5 years, more than half of were men (59%). The median latency of SS was 45 days. 13% of SS resolved after ICIs discontinuation or dose reduction. SS was significantly associated with ICIs (ROR = 11.19, 95%CI: 9.53–13.14; IC = 3.34, 95%CI: 2.85–3.93). The signal was also observed in anti-PD-1 (ROR025 = 9.20, IC025 = 2.75), anti-PD-L1 (ROR025 = 3.34, IC025 = 1.33), and combination therapy (ROR025 = 14.49, IC025 = 2.89). Conclusions This study suggested that ICIs significantly increased the risk of SS. This association was stronger in combination therapy.
- Published
- 2022
7. Van der Waals superlattices
- Author
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Xiangfeng Duan, Huaying Ren, and Zhong Wan
- Subjects
Multidisciplinary - Abstract
This perspective explores the development of van der Waals superlattices, which are manipulated and constructed at atomic thick level, and points out potential applications and possible future directions of this new class of materials.
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- 2022
8. Chiral molecular intercalation superlattices
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Qi Qian, Huaying Ren, Jingyuan Zhou, Zhong Wan, Jingxuan Zhou, Xingxu Yan, Jin Cai, Peiqi Wang, Bailing Li, Zdenek Sofer, Bo Li, Xidong Duan, Xiaoqing Pan, Yu Huang, and Xiangfeng Duan
- Subjects
Multidisciplinary - Abstract
The discovery of chiral-induced spin selectivity (CISS) opens up the possibility to manipulate spin orientation without external magnetic fields and enables new spintronic device designs
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- 2021
9. 6-inch uniform vertically-oriented graphene on soda-lime glass for photothermal applications
- Author
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Zhaolong Chen, Huaying Ren, Yue Qi, Zhongfan Liu, Haina Ci, Yanfeng Zhang, Xu-Dong Chen, and Jincan Zhang
- Subjects
Soda-lime glass ,Materials science ,Softening point ,Graphene ,Nanotechnology ,02 engineering and technology ,Substrate (electronics) ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,law.invention ,Plasma-enhanced chemical vapor deposition ,law ,Transmittance ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,Hybrid material - Abstract
Vertically-oriented graphene (VG) has many advantages over flat lying graphene, including a large surface area, exposed sharp edges, and non-stacking three-dimensional geometry. Recently, VG nanosheets assembled on specific substrates have been used for applications in supersensitive gas sensors and high-performance energy storage devices. However, to realize these intriguing applications, the direct growth of high-quality VG on a functional substrate is highly desired. Herein, we report the direct synthesis of VG nanosheets on traditional soda-lime glass due to its low-cost, good transparency, and compatibility with many applications encountered in daily life. This synthesis was achieved by a direct-current plasma enhanced chemical vapor deposition (dc-PECVD) route at 580 °C, which is right below the softening point of the glass, and featured a scale-up size ∼6 inches. Particularly, the fabricated VG nanosheets/glass hybrid materials at a transmittance range of 97%–34% exhibited excellent solarthermal performances, reflected by a 70%–130% increase in the surface temperature under simulated sunlight irradiation. We believe that this graphene glass hybrid material has great potential for use in future transparent “green-warmth” construction materials.
- Published
- 2018
10. Rapid growth of angle-confined large-domain graphene bicrystals
- Author
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Shuli Zhao, Jincan Zhang, Miao Tang, Manish Kumar Priydarshi, Zhongfan Liu, Huaying Ren, Huan Wang, Li Lin, Bing Deng, and Hailin Peng
- Subjects
Materials science ,Misorientation ,Graphene ,Nanotechnology ,02 engineering and technology ,Chemical vapor deposition ,Surface engineering ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Polycrystalline thin films ,law.invention ,law ,Lattice (order) ,General Materials Science ,Grain boundary ,Electrical and Electronic Engineering ,0210 nano-technology ,Graphene nanoribbons - Abstract
In the chemical vapor deposition growth of large-area graphene polycrystalline thin films, the coalescence of randomly oriented graphene domains results in a high density of uncertain grain boundaries (GBs). The structures and properties of various GBs are highly dependent on the misorientation angles between the graphene domains, which can significantly affect the performance of the graphene films and impede their industrial applications. Graphene bicrystals with a specific type of GB can be synthesized via the controllable growth of graphene domains with a predefined lattice orientation. Although the bicrystal has been widely investigated for traditional bulk materials, no successful synthesis strategy has been presented for growing two-dimensional graphene bicrystals. In this study, we demonstrate a simple approach for growing well-aligned large-domain graphene bicrystals with a confined tilt angle of 30° on a facilely recrystallized single-crystal Cu (100) substrate. Control of the density of the GBs with a misorientation angle of 30° was realized via the controllable rapid growth of subcentimeter graphene domains with the assistance of a cooperative catalytic surface-passivation treatment. The large-area production of graphene bicrystals consisting of the sole specific GBs with a tunable density provides a new material platform for fundamental studies and practical applications.
- Published
- 2017
11. A direct comparison of the interaction of bovine serum albumin and gelatin with sodium deoxycholate in aqueous solutions
- Author
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Huanfeng Ju, A'Dila Zhamanding, Xia Xin, Guiying Xu, Lin Wang, and Huaying Ren
- Subjects
Circular dichroism ,Aqueous solution ,Chromatography ,food.ingredient ,biology ,Chemistry ,Condensed Matter Physics ,Fluorescence ,Gelatin ,Atomic and Molecular Physics, and Optics ,Random coil ,Electronic, Optical and Magnetic Materials ,Surface tension ,food ,Pulmonary surfactant ,Materials Chemistry ,biology.protein ,Physical and Theoretical Chemistry ,Bovine serum albumin ,Spectroscopy - Abstract
Surface tension, fluorescence and circular dichroism (CD) methods have been used to investigate the interaction between a biological surfactant sodium deoxycholate (NaDC) and proteins including bovine serum albumin (BSA) and gelatin. It can be seen from the surface tension measurements that both NaDC/BSA and NaDC/gelatin systems can form complexes and the ability of NaDC/BSA to lower surface tension is more obvious than that of NaDC/gelatin. The formation of the complexes influences not only the polarity of the microenvironment of the systems but also their fluorescence spectra. The far-UV CD spectra shows that the α-helical network of BSA increases first and then decreases as the concentration of NaDC increases, while the random coil content of gelatin always increases. A model of interaction between protein and NaDC influenced by the concentration of NaDC has been brought out based on the data gained from this study.
- Published
- 2015
12. Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia
- Author
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Yaling Jing, Zuyi Chen, Rong Zhong, Huaying Ren, and Xianping Ding
- Subjects
Adult ,Male ,Infertility ,China ,Genotype ,Biology ,Asthenozoospermia ,Polymorphism, Single Nucleotide ,Young Adult ,Asian People ,Gene Frequency ,Genetics ,medicine ,Humans ,Allele ,Molecular Biology ,Allele frequency ,Gene ,Alleles ,Haplotype ,Case-control study ,Exons ,Sequence Analysis, DNA ,General Medicine ,Middle Aged ,medicine.disease ,Haplotypes ,Case-Control Studies - Abstract
Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chinese Han population. We recruited 240 asthenospermic men as a patient group and 256 normospermic men as a control group, and analyzed the semen parameters on the basis of World Health Organization (WHO) guidelines. The genetic polymorphisms in exon7 of NSUN7 were detected by DNA sequence analysis. The results were analyzed statistically and a P value0.05 was considered significant. There were two genetic polymorphisms, c.906CT and c.922TG, in exon7 of NSUN7. We found relatively similar genotypes and allele frequencies between the two groups (P = 0.928, P = 0.928, respectively). The combined genotypes of the two polymorphisms did not identify a haplotype associated with asthenospermia (P = 0.824, P = 0.824, respectively). Our findings revealed that genetic polymorphisms in exon7 of the NSUN7 gene are not associated with asthenospermia in Chinese Han men.
- Published
- 2015
13. Investigation of AZF microdeletions in patients with Klinefelter syndrome
- Author
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Ding Xp, Xuan Zhang, Huaying Ren, Ling Li, Dai Hy, Zheyu Chen, and Yao Zhang
- Subjects
Male ,medicine.medical_specialty ,Y chromosome microdeletion ,Sex Chromosome Disorders of Sex Development ,Population ,Biology ,Y chromosome ,Gastroenterology ,Male infertility ,Sequence-tagged site ,Klinefelter Syndrome ,Internal medicine ,Genotype ,Genetics ,medicine ,Humans ,education ,Molecular Biology ,Infertility, Male ,Sex Chromosome Aberrations ,Azoospermia ,Sequence Tagged Sites ,education.field_of_study ,Chromosomes, Human, Y ,Seminal Plasma Proteins ,General Medicine ,medicine.disease ,Phenotype ,Genetic Loci ,Chromosome Deletion ,Klinefelter syndrome ,Gene Deletion - Abstract
We investigated azoospermia region microdeletions in male infertility patients with Klinefelter syndrome (KFS), as well as the association between azoospermia symptoms in patients with KFS and Y chromosome microdeletion polymorphisms. A total of 111 cases with male infertility confirmed to have KFS (47, XXY) and 94 fertile men were included in this study. Peripheral blood was drawn and DNA was extracted from these samples. Multiplex polymerase chain reaction was performed to screen the partial deletions of 25 sequence-tagged sites on the Y chromosome. In 111 cases with KFS, 1 case contained the AZFb+d+c deletion. The Gr/Gr deletion was identified in 12 KFS cases and 5 control cases. In addition, the b2/b3 deletion was identified in 13 KFS cases and 6 control cases. There were no significant differences in phenotype and genotype of the 2 partial AZFc deletions between patients and controls (P > 0.05). Our results suggest that patients with KFS may also have Y chromosome microdeletions to varying degrees and that the gr/gr deletion and b2/b3 deletion may not play a role in the susceptible genetic background of azoospermia in patients with KFS in the Sichuan population.
- Published
- 2015
14. Graphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes
- Author
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Siyuan Zhao, Huaying Ren, Xiaojun Liu, Xuefeng Fu, Xiaojie Duan, Linlin Lu, Zheng Xu, Zhongfan Liu, Miao Tang, Bing Deng, and Hailin Peng
- Subjects
Materials science ,chemistry.chemical_element ,Bioengineering ,02 engineering and technology ,Local field potential ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,law ,medicine ,General Materials Science ,medicine.diagnostic_test ,Graphene ,Mechanical Engineering ,Magnetic resonance imaging ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Copper ,Magnetic susceptibility ,Electrophysiology ,Microelectrode ,chemistry ,Electrode ,0210 nano-technology ,030217 neurology & neurosurgery - Abstract
Magnetic resonance imaging (MRI) compatible neural electrodes are important for combining high-resolution electrophysiological measurements with more global MRI mapping of brain activity, which is critical for fundamental neuroscience studies, as well as clinical evaluation and monitoring. Copper is a favorable material to use in MRI because it has magnetic susceptibility close to water and tissues. However, the cytotoxicity of copper precludes its direct implantation for neural recording. Here, we overcome this limitation by developing a graphene encapsulated copper (G-Cu) microelectrode. The toxicity of copper is largely eliminated, as evidenced by the in vitro cell tests and in vivo histology studies. Local field potentials and single-unit spikes were recorded from rodent brains with the G-Cu microelectrodes. Notably, the G-Cu microelectrodes show no image artifacts in a 7.0 T MRI scanner, indicating minimal magnetic field distortion in their vicinity. This high MRI compatibility of our G-Cu probes would open up new opportunities for fundamental brain activity studies and clinical applications requiring continuous MRI and electrophysiological recordings.
- Published
- 2016
15. The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process
- Author
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Baoyang Ding, Lian Li, Shang Chen, Qi Yang, Jinfeng Wang, Lixuan Zang, Hengchang Zang, Huaying Ren, and Fengshan Wang
- Subjects
Chondroitin sulfate ,Mean squared error ,Chemistry ,near infrared spectroscopy ,lcsh:T ,Overtone ,Near-infrared spectroscopy ,Biomedical Engineering ,Analytical chemistry ,Medicine (miscellaneous) ,lcsh:Technology ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Scientific method ,Partial least squares regression ,lcsh:QC350-467 ,pathlength ,Ethanol precipitation ,Smoothing ,lcsh:Optics. Light ,variable selection - Abstract
Near infrared spectroscopy (NIRS) is based on molecular overtone and combination vibrations. It is difficult to assign specific features under complicated system. So it is necessary to find the relevance between NIRS and target compound. For this purpose, the chondroitin sulfate (CS) ethanol precipitation process was selected as the research model, and 90 samples of 5 different batches were collected and the content of CS was determined by modified carbazole method. The relevance between NIRS and CS was studied throughout optical pathlength, pretreatment methods and variables selection methods. In conclusion, the first derivative with Savitzky–Golay (SG) smoothing was selected as the best pretreatment, and the best spectral region was selected using interval partial least squares (iPLS) method under 1 mm optical cell. A multivariate calibration model was established using PLS algorithm for determining the content of CS, and the root mean square error of prediction (RMSEP) is 3.934 g⋅L-1. This method will have great potential in process analytical technology in the future.
- Published
- 2014
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