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4. Antioxidant activity and qualitative analysis of wheat bran polyphenols purified using HPD 600 macroporous resin

Author

TIAN Fu-lin, HUANG Wen-jing, ZHANG Chi, SHEN Wang-yang, and WU Fan

Subjects
wheat bran polyphenols, macroporous resin, purify, antioxidant, hplc-ms/ms, qualitative analysis, Food processing and manufacture, TP368-456
Abstract

Objective: A process was developed for the purification of bran polyphenols from HPD 600 macroporous resin. The purity and antioxidant activity of the extracts were analyzed before and after purification, and the polyphenol fractions in the purified products were characterized. Methods: The bound polyphenols in wheat bran were extracted by alkali hydrolysis, and the dynamic adsorption-desorption conditions of the macroporous resin were optimized by single-factor test to determine the optimal purification process. The antioxidant activity fraction was determined by ABTS and DPPH radical scavenging rate. The characterization of the polyphenol fraction in the purified product was completed by UPLC-MS/MS. Results: Under optimal process conditions, the purity of the polyphenols and the antioxidant activity of the purified product were significantly increased. The purified products contained mainly nine polyphenolic compounds, in order of retention time: p-hydroxybenzoic acid, caffeic acid, vanillin, p-coumaric acid, trans-ferulic acid and salicylic acid. Conclusion: The macroporous resin purification process is effective in enriching bran polyphenols and the resulting purified product has a significantly higher antioxidant capacity, while maintaining the richness of the polyphenolic species.

Published
2022
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6. 5S management improves the service quality in the outpatient-emergency pharmacy: from management process optimisation to staff capacity enhancement

Author

Huang, Wen-Jing, Zhang, Meng-Wan, Li, Bei-Yi, Wang, Xiao-Hui, Zhang, Chu-Han, and Yu, Jian-Guang

Abstract

ObjectiveAs a high-efficiency demanding department in a hospital, the outpatient pharmacy has a great need for quality improvement to provide superior medical service for patients. Little is known about the application of 5S management in a hospital pharmacy department. The aim of this study was to evaluate the impacts of 5S management on pharmaceutical service quality and staff capacity in the outpatient-emergency pharmacy.MethodsWe carried out a 5S project in the outpatient-emergency pharmacy at a local hospital that involved processes including waste elimination, workplace standardisation, and optimisation of workflow and staff quality, and then evaluated the effects of the project.ResultsThe equipment and items in the outpatient-emergency pharmacy were sorted. All the drugs were categorised and put in order. The redesigned workspace and standardised workflow during the project improved the accuracy and efficiency of drug dispensing. The satisfaction rate of patients regarding the pharmaceutical service quality in the outpatient-emergency pharmacy was elevated, as well as the satisfaction rate of pharmacists about their work experiences. The optimisation of objective conditions also stimulated a positive working attitude and professional ability promotion of pharmacists in the outpatient-emergency pharmacy.ConclusionsIn this study, the 5S management method has proven useful for quality and efficiency improvement in the outpatient-emergency pharmacy, and could be generalised to other departments in a hospital, which provides further evidence of the advantages of the Lean tool in healthcare system management.

Published
2024
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24. Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis

Author

Wang, Zhao, Yang, Mai-Qing, Lei, Lei, Fei, Liang-Ru, Zheng, Yi-Wen, Huang, Wen-Jing, Li, Zhi-Han, Liu, Chen-Chen, and Xu, Hong-Tao

Subjects
Wnt signaling pathway, keratin 17, Cancer Management and Research, epithelial mesenchymal transition, proliferation, invasion, non-small cell lung cancer, respiratory tract diseases, Original Research
Abstract

Zhao Wang,1,2 Mai-Qing Yang,1,3 Lei Lei,1 Liang-Ru Fei,1 Yi-Wen Zheng,1 Wen-Jing Huang,1 Zhi-Han Li,1 Chen-Chen Liu,1 Hong-Tao Xu11Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Pathology, General Hospital of Heilongjiang Land Reclamation Bureau, Harbin 150088, People’s Republic of China; 3Department of Pathology, Changyi People’s Hospital, Changyi, People’s Republic of ChinaPurpose: Keratin 17 (KRT17) is a 48 KDa type I intermediate filament, which is mainly expressed in epithelial basal cells. KRT17 has been shown to be overexpressed in many malignant tumors and play an important role in the occurrence and development of tumors. Therefore, this study explored the role and underlying mechanism of KRT17 in non-small cell lung cancers (NSCLC).Methods: KRT17 expression and its correlations with clinicopathological factors were examined in lung cancer tissues by immunohistochemistry. The prognosis value of KRT17 in NSCLCs was retrieved from The Cancer Genome Atlas (TCGA) online databases. The expression level of KRT17 was increased or decreased by KRT17 gene transfection or small RNA interference in lung cancer cells, respectively. Further, proliferation and invasiveness of lung cancer cells were determined by cell proliferation and invasion assays, respectively. Finally, expression levels of proteins related to Wnt signaling pathways and epithelial mesenchymal transition (EMT) were detected by Western blot.Results: The expression level of KRT17 in NSCLCs was significantly higher than normal lung tissues. High expression of KRT17 predicted poor prognosis of patients with NSCLCs, especially lung adenocarcinomas, and was correlated with poor differentiation and lymphatic metastasis. Overexpression of KRT17 enhanced, while KRT17 knockdown inhibited, the proliferation and invasiveness of lung cancer cells. Overexpression of KRT17 up-regulated β-catenin activity and levels of Wnt target genes, such as cyclin D1, c-Myc, and MMP7. Moreover, KRT17 promoted EMT by up-regulating Vimentin, MMP-9, and Snail expression and down-regulating E-cadherin expression.Conclusion: Overexpression of KRT17 is common in NSCLCs and indicates poor prognosis. Overexpression of KRT17 enhances the proliferation and invasiveness of NSCLC cells by activating the Wnt signaling pathway and EMT process. KRT17 is a potential indicator of NSCLC progression and poor survival.Keywords: keratin 17, non-small cell lung cancer, Wnt signaling pathway, epithelial mesenchymal transition, proliferation, invasion

Published
2019

25. Additional file 1: of Molecular characterization of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China

Author

Zhang, Xue-Lian, Shao, Jian-Wei, Li, Xiao-Wen, Mei, Min-Min, Jin-Yue Guo, Li, Wen-Feng, Huang, Wen-Jing, Chi, Shi-Hong, Yuan, Sheng, Li, Zhi-Li, and Shu-Jian Huang

Subjects
viruses, virus diseases
Abstract

Table S1. Oligonucleotide primers used to amplify and sequence the L/S/M-class genes of novel pathogen Muscovy duck reovirus (N-MDRV) SH12 and DH13. (DOCX 17 kb)

Published
2019
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33. Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial

Author

Jin, De, primary, Huang, Wen-jing, additional, Meng, Xiang, additional, Yang, Fan, additional, Zheng, Yu-jiao, additional, Bao, Qi, additional, Zhang, Mei-zhen, additional, Yang, Ya-nan, additional, Ni, Qing, additional, Lian, Feng-mei, additional, and Tong, Xiao-lin, additional

Published
2017
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34. Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate

Author

Zhang, Jian-ye, primary, Huang, Wen-jing, additional, Sun, Hong-mei, additional, Liu, Yun, additional, Zhao, Xiao-qin, additional, Tang, Si-li, additional, Sun, Ming-na, additional, Wang, Sheng, additional, Li, Jia-jun, additional, Zhang, Ling-ling, additional, Zhou, Jun-hua, additional, Pan, Qian-rong, additional, and Chen, Hu-biao, additional

Published
2017
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35. World Congress Integrative Medicine & Health 2017: part two

Author

Ee, Carolyn, primary, Thuraisingam, Sharmala, additional, Pirotta, Marie, additional, French, Simon, additional, Xue, Charlie, additional, Teede, Helena, additional, Kristoffersen, Agnete E., additional, Sirois, Fuschia, additional, Stub, Trine, additional, Engler, Jennifer, additional, Joos, Stefanie, additional, Güthlin, Corina, additional, Felenda, Jennifer, additional, Beckmann, Christiane, additional, Stintzing, Florian, additional, Evans, Roni, additional, Bronfort, Gert, additional, Keefe, Daniel, additional, Taberko, Anna, additional, Hanson, Linda, additional, Haley, Alex, additional, Ma, Haiwei, additional, Jolton, Joseph, additional, Yarosh, Lana, additional, Keefe, Francis, additional, Nam, Jung, additional, Ojala, Liwanag, additional, Kreitzer, Mary J., additional, Fink, Careen, additional, Kraft, Karin, additional, Flower, Andrew, additional, Lewith, George, additional, Harman, Kim, additional, Stuart, Beth, additional, Bishop, Felicity L., additional, Frawley, Jane, additional, Füleki, Lilla, additional, Kiss, Eva, additional, Vancsik, Tamas, additional, Krenacs, Tibor, additional, Funabashi, Martha, additional, Pohlman, Katherine A., additional, Mior, Silvano, additional, Thiel, Haymo, additional, Hill, Michael D., additional, Cassidy, David J., additional, Westaway, Michael, additional, Yager, Jerome, additional, Hurwitz, Eric, additional, Kawchuk, Gregory N., additional, O’Beirne, Maeve, additional, Vohra, Sunita, additional, Gaboury, Isabelle, additional, Morin, Chantal, additional, Gaertner, Katharina, additional, Torchetti, Loredana, additional, Frei-Erb, Martin, additional, Kundi, Michael, additional, Frass, Michael, additional, Gallo, Eugenia, additional, Maggini, Valentina, additional, Comite, Mattia, additional, Sofi, Francesco, additional, Baccetti, Sonia, additional, Vannacci, Alfredo, additional, Di Stefano, Mariella, additional, Monechi, Maria V., additional, Gori, Luigi, additional, Rossi, Elio, additional, Firenzuoli, Fabio, additional, Mediati, Rocco D., additional, Ballerini, Giovanna, additional, Gardiner, Paula, additional, Lestoquoy, Anna S., additional, Negash, Lily, additional, Stillman, Sarah, additional, Shah, Prachi, additional, Liebschutz, Jane, additional, Adelstein, Pamela, additional, Farrell-Riley, Christine, additional, Brackup, Ivy, additional, Penti, Brian, additional, Saper, Robert, additional, Sampedro, Isabel Giralt, additional, Carvajal, Gilda, additional, Gleiss, Andreas, additional, Gross, Marie M., additional, Brendlin, Dorothea, additional, Röttger, Jonas, additional, Stritter, Wiebke, additional, Seifert, Georg, additional, Grzanna, Noelle, additional, Stange, Rainer, additional, Guendling, Peter W., additional, Gu, Wen, additional, Lu, Yan, additional, Wang, Jie, additional, Zhang, Chengcheng, additional, Bai, Hua, additional, He, Yuxi, additional, Zhang, Xiaoxu, additional, Zhang, Zhengju, additional, Wang, Dali, additional, Meng, Fengxian, additional, Hagel, Alexander, additional, Albrecht, Heinz, additional, Vollbracht, Claudia, additional, Dauth, Wolfgang, additional, Hagel, Wolfgang, additional, Vitali, Francesco, additional, Ganzleben, Ingo, additional, Schultis, Hans, additional, Konturek, Peter, additional, Stein, Jürgen, additional, Neurath, Markus, additional, Raithel, Martin, additional, Krick, Bianka, additional, Haller, Heidemarie, additional, Klose, Petra, additional, Dobos, Gustav, additional, Kümmel, Sherko, additional, Cramer, Holger, additional, Saha, Felix J., additional, Kowoll, Anna, additional, Ebner, Barbara, additional, Berger, Bettina, additional, Choi, Kyung-Eun, additional, He, Lisha, additional, Wang, Han, additional, He, X., additional, Gu, C., additional, Zhang, Y., additional, Zhao, Linhua, additional, Tong, Xiaolin, additional, He, Xinhui, additional, Gu, Chengjuan, additional, Zhang, Ying, additional, Ho, Robin S. T., additional, Chung, Vincent C. H., additional, Wu, Xinyin, additional, Wong, Charlene H. L., additional, Wu, Justin C. Y., additional, Wong, Samuel Y. S., additional, Lau, Alexander Y. L., additional, Sit, Regina W. S., additional, Wong, Wendy, additional, Holmes, Michelle, additional, Bishop, Felicity, additional, Calman, Lynn, additional, Newell, Dave, additional, Field, Jonathan, additional, Htut, Win L., additional, Han, Dongwoon, additional, Choi, Da I., additional, Choi, Soo J., additional, Kim, Ha Y., additional, Hwang, Jung H., additional, Huang, Ching W., additional, Jang, Bo H., additional, Chen, Fang P., additional, Ko, Seong G., additional, Huang, Wenjing, additional, Jin, De, additional, Lian, Fengmei, additional, Jang, Soobin, additional, Kim, Kyeong H., additional, Lee, Eun K., additional, Sun, Seung H., additional, Go, Ho Y., additional, Ko, Youme, additional, Park, Sunju, additional, Shin, Yong C., additional, Janik, Hubert, additional, Greiffenhagen, Natalie, additional, Bolte, Jürgen, additional, Jaworski, Mariusz, additional, Adamus, Miroslawa, additional, Dobrzynska, Aleksandra, additional, Jeitler, Michael, additional, Jaspers, Jessica, additional, von Scheidt, Christel, additional, Koch, Barbara, additional, Michalsen, Andreas, additional, Steckhan, Nico, additional, Kessler, Christian, additional, Huang, Wen-jing, additional, Pang, Bing, additional, Lian, Feng-Mei, additional, Jong, Miek, additional, Baars, Erik, additional, Glockmann, Anja, additional, Hamre, Harald, additional, Kainuma, Mosaburo, additional, Murakami, Aya, additional, Kubota, Toshio, additional, Kobayashi, Daisuke, additional, Sumoto, Yasuhiro, additional, Furusyo, Norihiro, additional, Ando, Shin-Ichi, additional, Shimazoe, Takao, additional, Kelber, Olaf, additional, Verjee, S., additional, Gorgus, Eva, additional, Schrenk, Dieter, additional, Kemper, Kathi, additional, Hill, Ellie, additional, Rao, Nisha, additional, Gascon, Gregg, additional, Mahan, John, additional, Kienle, Gunver, additional, Dietrich, Jörg, additional, Schmoor, Claudia, additional, Huber, Roman, additional, Kim, Weon H., additional, Ahmed, Mansoor, additional, He, Luzhu, additional, Hwang, Jung Hye, additional, Meggyeshazi, Nora, additional, Kovago, Csaba, additional, Klaus, Anne K., additional, Zerm, Roland, additional, Pranga, Danilo, additional, Ostermann, Thomas, additional, Reif, Marcus, additional, von Laue, Hans Broder, additional, Brinkhaus, Benno, additional, Kröz, Matthias, additional, Recchia, Daniela Rodrigues, additional, von Laue, Hans B., additional, Klein-Laansma, Christien T., additional, Jong, Mats, additional, von Hagens, Cornelia, additional, Jansen, Jean P., additional, van Wietmarschen, Herman, additional, Jong, Miek C., additional, Sun, Seung-Ho, additional, Go, Ho-Yeon, additional, Jeon, Chan-Yong, additional, Song, Yun-Kyung, additional, Ko, Seong-Gyu, additional, Koch, Anna K., additional, Rabsilber, Sybille, additional, Lauche, Romy, additional, Langhorst, Jost, additional, Trifunovic-Koenig, Milena, additional, Koster, Evi, additional, Delnoij, Diana, additional, Kroll, Lena, additional, Weiss, Kathrin, additional, Kubo, Ai, additional, Hendlish, Sarah, additional, Altschuler, Andrea, additional, Connolly, Nancy, additional, Avins, Andy, additional, Wardle, Jon, additional, Lee, David, additional, Sibbritt, David, additional, Adams, Jon, additional, Park, Crystal, additional, Mishra, Gita, additional, Lechner, Johann, additional, Lee, Inseon, additional, Chae, Younbyoung, additional, Lee, Jisu, additional, Cho, Seung H., additional, Choi, Yujin, additional, Lee, Jee Y., additional, Ryu, Han S., additional, Yoon, Sung S., additional, Oh, Hye K., additional, Hyun, Lyun K., additional, Kim, Jin O., additional, Yoon, Seong W., additional, Lee, Ju-Yeon, additional, Shin, Sang-Hoon, additional, Jang, Min, additional, Müller, Indra, additional, Park, So-Hyun Janson, additional, Laird, Lance, additional, Mitchell, Suzanne, additional, Li, Xiaofei, additional, Wang, Yunhui, additional, Zhen, Jianhua, additional, Yu, He, additional, Liu, Tiegang, additional, Gu, Xiaohong, additional, Liu, Hui, additional, Ma, Weiguo, additional, Shang, Xuezheng, additional, Bai, Yu, additional, Liu, Wei, additional, Rooney, Collin, additional, Smith, Amos, additional, Lopes, Shirlene, additional, Demarzo, Marcelo, additional, do Patrocínio Nunes, Maria, additional, Lorenz, Peter, additional, Gründemann, Carsten, additional, Heinrich, Miriam, additional, Garcia-Käufer, Manuel, additional, Grunewald, Franziska, additional, Messerschmidt, Silke, additional, Herrick, Anja, additional, Gruber, Kim, additional, Knödler, Matthias, additional, Steinborn, Carmen, additional, Lu, Taoying, additional, Wang, Lixin, additional, Wu, Darong, additional, Luberto, Christina M, additional, Hall, Daniel L., additional, Chad-Friedman, Emma, additional, Lechner, Suzanne, additional, Park, Elyse R., additional, Luberto, Christina M., additional, Park, Elyse, additional, Goodman, Janice, additional, Luer, Sonja, additional, Heri, Matthias, additional, von Ammon, Klaus, additional, Landini, Ida, additional, Lapucci, Andrea, additional, Nobili, Stefania, additional, Mini, Enrico, additional, McDermott, Clare, additional, Richards, Selwyn, additional, Cox, Diane, additional, Frossell, Sarah, additional, Leydon, Geraldine, additional, Eyles, Caroline, additional, Raphael, Hilly, additional, Rogers, Rachael, additional, Selby, Michelle, additional, Adler, Charlotte, additional, Allam, Jo, additional, Bu, Xiangwei, additional, Zhang, Honghong, additional, Zhang, Jianpeng, additional, Mikolasek, Michael, additional, Berg, Jonas, additional, Witt, Claudia, additional, Barth, Jürgen, additional, Miskulin, Ivan, additional, Lalic, Zdenka, additional, Miskulin, Maja, additional, Dumic, Albina, additional, Sebo, Damir, additional, Vcev, Aleksandar, additional, Mohammed, Nasr A. A., additional, Choi, Soo Jeung, additional, Im, Hyea Bin, additional, Mukherjee, Anwesha, additional, Kandhare, Amit, additional, Bodhankar, Subhash, additional, Thakurdesai, Prasad, additional, Munk, Niki, additional, Evans, Erica, additional, Froman, Amanda, additional, Kline, Matthew, additional, Bair, Matthew J., additional, Musial, Frauke, additional, Alræk, Terje, additional, Hamre, Harald J., additional, Björkman, Lars, additional, Fønnebø, Vinjar M., additional, Lian, Feng-mei, additional, Ni, Qing, additional, Tong, Xiao-lin, additional, Li, Xin-long, additional, Liu, Wen-ke, additional, Feng, Shuo, additional, Zhao, Xi-yan, additional, Zheng, Yu-jiao, additional, Zhao, Xue-min, additional, Lin, Yi-qun, additional, Zhao, Tian-yu, additional, Zhao, Xi-Yan, additional, Phd, Hui Che, additional, Zhang, Chen, additional, Liu, Feng, additional, Zhao, Lin-hua, additional, Ye, Ru, additional, Gu, Cheng-juan, additional, Peng, Wenbo, additional, De Carvalho, Diana, additional, El-Bayoumi, Mohamed, additional, Haig, Bob, additional, Kelly, Kimbalin, additional, Wade, Darrell J., additional, Portalupi, Emanuela, additional, Gobo, Giampietro, additional, Bellavita, Luigi, additional, Guglielmetti, Chiara, additional, Raak, Christa, additional, Teuber, Myriam, additional, Molsberger, Friedrich, additional, von Rath, Ulrich, additional, Reichelt, Ulrike, additional, Schwanebeck, Uta, additional, Zeil, Sabine, additional, Vogelberg, Christian, additional, Veintimilla, Dolores Rodríguez, additional, Mery, Guerrero Tapia, additional, Villavicencio, Marisol Maldonado, additional, Moran, Sandra Herrera, additional, Sachse, Christian, additional, Gündlin, Peter W, additional, Sahebkarkhorasani, Monirsadat, additional, Azizi, Hoda, additional, Schumann, Dania, additional, Sundberg, Tobias, additional, Leach, Matthew J., additional, Seca, Susana, additional, Greten, Henry, additional, Selliah, Sugir, additional, Shakya, Anu, additional, Kim, Ha Yun, additional, Im, Hyea B., additional, Sherbakova, Anna, additional, Ulrich-Merzenich, Gudrun, additional, Abdel-Aziz, Heba, additional, Sibinga, Erica, additional, Webb, Lindsey, additional, Ellen, Jonathan, additional, Skrautvol, Kari, additional, Nåden, Dagfinn, additional, Song, Rhayun, additional, Grabowska, Weronika, additional, Osypiuk, Kamila, additional, Diaz, Gloria V., additional, Bonato, Paolo, additional, Park, Moonkyoung, additional, Hausdorff, Jeffrey, additional, Fox, Michael, additional, Sudarsky, Lewis R., additional, Tarsy, Daniel, additional, Novakowski, James, additional, Macklin, Eric A., additional, Wayne, Peter M., additional, Hwang, Inok, additional, Ahn, Sukhee, additional, Lee, Myung-Ah, additional, Sohn, Min K., additional, Sorokin, Oleg, additional, Heydeck, Dagmar, additional, Borchert, Astrid, additional, Hohmann, Christoph-Daniel, additional, Kühn, Harmut, additional, Kirschbaum, Clemens, additional, Stalder, Tobias, additional, Stöckigt, Barbara, additional, Teut, Michael, additional, Suhr, Ralf, additional, Sulmann, Daniela, additional, Streeter, Chris, additional, Gerbarg, Patrica, additional, Silveri, Marisa, additional, Brown, Richard, additional, Jensen, John, additional, Rutert, Britta, additional, Eggert, Angelika, additional, Längler, Alfred, additional, Holmberg, Christine, additional, Sun, Jin, additional, Deng, Xin, additional, Li, Wen-Yuan, additional, Wen, Bin, additional, Robinson, Nicola, additional, Liu, Jian-Ping, additional, Sung, Hyun K., additional, Yang, Narae, additional, Shin, Seon M., additional, Jung, Hee, additional, Kim, Young J., additional, Jung, Woo S., additional, Park, Tae Y., additional, Suzuki, Kiyoshi, additional, Ito, Toshinori, additional, Uchida, Seiya, additional, Kamohara, Seika, additional, Ono, Naoya, additional, Takamura, Mitsuyuki, additional, Yokochi, Ayumu, additional, Maruyama, Kazuo, additional, Tapia, Patricio, additional, Thabaut, Katarzyna, additional, Thronicke, Anja, additional, Steele, Megan, additional, Matthes, Harald, additional, Herbstreit, Cornelia, additional, Schad, Friedemann, additional, Tian, Jiaxing, additional, Yang, Libo, additional, Tian, Tian, additional, Zhang, Hewei, additional, Tian, Xia, additional, Wang, CongCong, additional, Chai, Qian Yun, additional, Zhang, Lijuan, additional, Xia, Ruyu, additional, Huang, Na, additional, Fei, Yutong, additional, Liu, Jianpin, additional, Trent, Natalie, additional, Miraglia, Mindy, additional, Dusek, Jeffrey, additional, Pasalis, Edi, additional, Khalsa, Sat B., additional, Trifunovic-König, Milena, additional, Koch, Anna, additional, Uebelacker, Lisa, additional, Tremont, Geoffrey, additional, Gillette, Lee, additional, Epstein-Lubow, Gary, additional, Strong, David, additional, Abrantes, Ana, additional, Tyrka, Audrey, additional, Tran, Tanya, additional, Gaudiano, Brandon, additional, Miller, Ivan, additional, Ullmann, Gerhild, additional, Li, Yuhua, additional, Vaidya, Sujata, additional, Marathe, Vinod, additional, Vale, Ana C., additional, Motta, Jacquelyne, additional, Donadão, Fabíola, additional, Valente, Angela C., additional, Valente, Luana C. Carvalho, additional, Ghelman, Ricardo, additional, Vesovic, Dusan, additional, Jevdic, Dragan, additional, Jevdic, Aleksandar, additional, Jevdic, Katarina, additional, Djacic, Mihael, additional, Letic, Dragica, additional, Bozic, Drago, additional, Markovic, Marija, additional, Dunjic, Slobodan, additional, Ruscuklic, Gordana, additional, Baksa, Dezire, additional, Vrca, Kenan, additional, Vincent, Ann, additional, Wahner-Roedler, Dietlind, additional, Whipple, Mary, additional, Vogelius, Maria M., additional, Friesecke, Iris, additional, Gündling, Peter W., additional, Mahapatra, Saswati, additional, Hynes, Rebecca, additional, Van Rooy, Kimberly, additional, Looker, Sherry, additional, Ghosh, Aditya, additional, Bauer, Brent, additional, Cutshall, Susanne, additional, Walach, Harald, additional, Flores, Ana Borges, additional, Ofner, Michael, additional, Kastner, Andreas, additional, Schwarzl, Gerhard, additional, Schwameder, Hermann, additional, Alexander, Nathalie, additional, Strutzenberger, Gerda, additional, Bu, Xianwei, additional, Zhang, Jianping, additional, Wang, Shang, additional, Shi, Jinfeng, additional, Hao, Yu, additional, Wu, Jun, additional, Qiu, Zeji, additional, Wang, Yuh-Hai, additional, Lou, Chi-Jung, additional, Watts, Sam, additional, Wayne, Peter, additional, Vergara-Diaz, Gloria, additional, Gow, Brian, additional, Miranda, Jose, additional, Sudarsky, Lewis, additional, Macklin, Eric, additional, Wode, Kathrin, additional, Bergqvist, Jenny, additional, Bernhardsson, Britt-Marie, additional, Nordberg, Johanna Hök, additional, Sharp, Lena, additional, Henriksson, Roger, additional, Woo, Yeonju, additional, Hyun, Min K., additional, Wu, Hao, additional, Wang, Tian-Fang, additional, Zhao, Yan, additional, Wei, Yu, additional, Tian, Lei, additional, He, Lei, additional, Wang, Xue, additional, Wu, Ruohan, additional, Han, Mei, additional, Caldwell, Patrina H. Y., additional, Liu, Shigang, additional, Zhang, Jing, additional, Liu, Jianping, additional, Chai, Qianyun, additional, Guo, Zhongning, additional, Wang, Congcong, additional, Liu, Zhijun, additional, Li, Xun, additional, Yang, I. J., additional, Lincha, V. Ruberio, additional, Ahn, S. H., additional, Lee, D. U., additional, Shin, H. M., additional, Yang, Lu, additional, Yang, N., additional, Sung, H., additional, Shin, S. M., additional, Go, H. Y., additional, Jung, H., additional, Kim, Y., additional, Park, T. Y., additional, Yap, Angela, additional, Kwan, Yu H., additional, Tan, Chuen S., additional, Ibrahim, Syed, additional, Ang, Seng B., additional, Yayi, Alfred, additional, Yoo, Jeong E., additional, Yoo, Ho R., additional, Jang, Sae B., additional, Lee, Hye L., additional, Youssef, Ala’a, additional, Ezzat, Shahira, additional, Motaal, Amira Abdel, additional, El-Askary, Hesham, additional, Yu, Xiaotong, additional, Cui, Yashan, additional, Yun, Younghee, additional, Ahn, Jin-Hyang, additional, Jang, Bo-Hyung, additional, Kim, Kyu-Seok, additional, Choi, Inhwa, additional, Glinz, Augustina, additional, ten Brink, Fadime, additional, Büssing, Arnd, additional, Gutenbrunner, Christoph, additional, Helbrecht, Bert, additional, Fang, Tiesheng, additional, Meng, Fengxion, additional, Shen, Zhiming, additional, Zhang, Ruixin, additional, Wu, Fan, additional, Li, Ming, additional, Xuan, Xinyun, additional, Shen, Xueyong, additional, Ren, Ke, additional, Berman, Brian, additional, Zheng, Zian, additional, Wan, Yuxiang, additional, Ma, Xueyan, additional, Dong, Fei, additional, Zick, Suzie, additional, Harris, Richard, additional, Bae, Go E., additional, Kwon, Jung N., additional, Lee, Hye Y., additional, Nam, Jong K., additional, Lee, Sang D., additional, Lee, Dong H., additional, Han, Ji Y., additional, Yun, Young J., additional, Lee, Ji H., additional, Park, Hye L., additional, Park, Seong H., additional, Bocci, Chiara, additional, Ivaldi, Giovanni B., additional, Vietti, Ilaria, additional, Meaglia, Ilaria, additional, Guffi, Marta, additional, Ruggiero, Rubina, additional, Gualea, Marita, additional, Longa, Emanuela, additional, Bonucci, Massimo, additional, Croke, Sarah, additional, Rodriguez, Lourdes Diaz, additional, Caracuel-Martínez, Juan C., additional, Fajardo-Rodríguez, Manuel F., additional, Ariza-García, Angélica, additional, la Fuente, Francisca García-De, additional, Arroyo-Morales, Manuel, additional, Estrems, Maria S., additional, Gómez, Vicente G., additional, Sabater, Mónica Valero, additional, Ferreri, Rosaria, additional, Bernardini, Simonetta, additional, Pulcri, Roberto, additional, Cracolici, Franco, additional, Rinaldi, Massimo, additional, Porciani, Claudio, additional, Fisher, Peter, additional, Hughes, John, additional, Mendoza, Ariadna, additional, MacPherson, Hugh, additional, Filshie, Jacqueline, additional, Di Francesco, Antonia, additional, Bernardini, Alberto, additional, Messe, Monica, additional, Primitivo, Vincenzo, additional, Iasella, Piera A., additional, Taminato, Monica, additional, Alcantara, Jaqueline Do Carmo, additional, De Oliveira, Katia R., additional, Rodrigues, Debora C. De Azevedo, additional, Mumme, Juliana R. Campana, additional, Sunakozawa, Olga K. Matsumoto, additional, Filho, Vicente Odone, additional, Goldenberg, Joshua, additional, Day, Andrew, additional, Sasagawa, Masa, additional, Ward, Lesley, additional, Cooley, Kieran, additional, Gunnarsdottir, Thora, additional, Hjaltadottir, Ingibjorg, additional, Hajimonfarednejad, Mahdie, additional, Hannan, Nicole, additional, Hellsing, Rut, additional, Andermo, Susanne, additional, Arman, Maria, additional, von Hörsten, Iris, additional, Torrielo, Patricia Vásquez, additional, Vilaró, Carmen L. Andrade, additional, Cabrera, Francisco Cerda, additional, Hui, Henny, additional, Ziea, Eric, additional, Tsui, Dora, additional, Hsieh, Joyce, additional, Lam, Christine, additional, Chan, Edith, additional, Jensen, Mark P., additional, Battalio, Samuel L., additional, Chan, Joy, additional, Edwards, Karlyn A., additional, Gertz, Kevin J., additional, Day, Melissa A., additional, Sherlin, Leslie H., additional, Ehde, Dawn M., additional, Jang, Bo-Hyoung, additional, Börner, Anja, additional, Lee, Jihong, additional, Lee, Boram, additional, Chang, Gyu T., additional, Menassa, Alejandra, additional, Motoo, Yoshiharu, additional, Müller, Jürgen, additional, Rabini, Sabine, additional, Vinson, Bettina, additional, Storr, Martin, additional, Niemeijer, Martin, additional, Hoekman, Joop, additional, Ruijssenaaars, Wied, additional, Njoku, Faith C., additional, Norheim, Arne J., additional, Okumus, Filiz, additional, and Oncu-Celik, Halime, additional

Published
2017
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36. Gray Matter Volumes in Patients with Chronic Fatigue Syndrome

Author

Tang, Le-wei, Zheng, Hui, Chen, Liang, Zhou, Si-yuan, Huang, Wen-jing, Li, Ying, and Wu, Xi

Subjects
musculoskeletal diseases, Article Subject, virus diseases, human activities, nervous system diseases
Abstract

Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue with uncertain pathologic mechanism. Neuroimage may be an important key to unveil the central nervous system (CNS) mechanism in CFS. Although most of the studies found gray matter (GM) volumes reduced in some brain regions in CFS, there are many factors that could affect GM volumes in CFS, including chronic pain, stress, psychiatric disorder, physical activity, and insomnia, which may bias the results. In this paper, through reviewing recent literatures, we discussed these interferential factors, which overlap with the symptoms of CFS.

Published
2015
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37. Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial.

Author

De Jin, Wen-jing Huang, Xiang Meng, Fan Yang, Yu-jiao Zheng, Qi Bao, Mei-zhen Zhang, Ya-nan Yang, Qing Ni, Feng-mei Lian, Xiao-lin Tong, Jin, De, Huang, Wen-Jing, Meng, Xiang, Yang, Fan, Zheng, Yu-Jiao, Bao, Qi, Zhang, Mei-Zhen, Yang, Ya-Nan, and Ni, Qing

Subjects
TYPE 2 diabetes diagnosis, TYPE 2 diabetes treatment, PATIENT compliance, CHINESE medicine, CLINICAL trials
Abstract

Background: Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirely satisfactory. Preliminary studies indicated that the Chinese herbal TangBi Formula may alleviate signs and symptoms and improve the velocity of nerve conduction in patients with DSPN. This study was designed to determine if Chinese herbal medicine used in combination with conventional treatment is more effective than conventional treatment alone.Methods/design: We are conducting a multicenter, placebo-controlled, double-blind, randomized, controlled clinical trial as a means of assessing the therapeutic effects of traditional Chinese medicine (TCM) treatment. A total of 188 patients will be randomized in a 1:1 ratio to a treatment group (TangBi Formula plus mecobalamin) and a control group (placebo plus mecobalamin). The test period lasts 6 months, during which all of the patients will be given standard medical care as recommended by established guidelines. The primary outcome will be development of differences in changes in clinical symptoms and signs in patients and changes in Michigan Diabetic Neuropathy Score (MDNS) between the two groups before and after treatment. The secondary outcome will be changes in nerve conduction velocity and in single clinical signs and symptoms. Safety assessments and adverse events will also be evaluated.Discussion: We postulate that patients with DSPN will benefit from therapy that includes TCM. If successful, this work will provide an evidence-based complementary therapeutic approach for treatment of DSPN.Trial Registration: ClinicalTrials.gov, NCT03010241 . Registered on 2 January 2017. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells

Author

Luo, Lan, primary, Kawakatsu, Miho, additional, Guo, Chao-Wan, additional, Urata, Yoshishige, additional, Huang, Wen-Jing, additional, Ali, Haytham, additional, Doi, Hanako, additional, Kitajima, Yuriko, additional, Tanaka, Takayuki, additional, Goto, Shinji, additional, Ono, Yusuke, additional, Xin, Hong-Bo, additional, Hamano, Kimikazu, additional, and Li, Tao-Sheng, additional

Published
2014
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40. N6-methyladenosine of TRIM27enhances the stem cell-type phenotype of cisplatin-resistant colorectal cancer cells

Author

Zheng, Jun-qiong, Zhan, Ying, Huang, Wen-jing, Chen, Zhi-yong, and Wu, Wei-hao

Abstract

Colorectal cancer (CRC), classified as a lethal form of cancer, substantially threatens human well-being. Cancer stem cells (CSCs) reflect subsets for cancerous cells having basic stem-cell type properties, being significantly involved in the development of chemoresistance and tumor relapsing. The aberrant TRIM27expression in various types of cancer indicates its potential involvement in cancer growth and progression. The current understanding of the TRIM27involvement in CRC remains limited. In current study indicated that TRIM27can potentially promote CSC-type phenotype of Cisplatin (DDP)-resistant CRC cells. YTHDF1recruitment onto m6A-amended TRIM27was crucial for facilitating the TRIM27translating process in DDP-resistant CRC cells. The present research proposes that TRIM27exhibits an oncogenic role by enhancing the CSC-type properties in DDP-resistant CRC viathe m6A-modified pathway. The potential therapy for combating the relapse of CRC may include TRIM27and YTHDF1, as they have been found to have significant roles in promoting CSC-type phenotypic characteristics.

Published
2023
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41. Prim-O-glucosycimifugin attenuates liver injury in septic mice by inhibiting NLRP3 inflammasome/caspase-1 signaling cascades in macrophages.

Author

Liu, Lin-Ling, Yan, Xin, Xue, Kun-Yue, Wang, Xue-Mei, Li, Ling-Yu, Chen, Hong-Ying, Li, Ru-Li, Li, He, Lan, Jie, Xin, Juan-Juan, Li, Xue, Zhuo, Cai-Li, Wu, Zhuang, Zhang, Die, Huang, Wen-Jing, Wang, Ying-Ling, Li, Xin-Yue, Jiang, Wei, and Zhang, Heng-Yu

Abstract

Background: Liver dysfunction and liver failure are serious complications of sepsis, directly leading to septic progression and death. Now, there is no specific therapeutics available for sepsis-related liver dysfunction. Prim-O-glucosylcimifugin (POG), a chromone richest in the roots of Saposhnikovia divaricata (Turcz.) Schischk, is usually used to treat headache, rheumatoid arthritis and tetanus. While, the underlying mechanisms of POG against sepsis-induced liver damage and dysfunction are still not clear.Purpose: To study the anti-sepsis effect of POG, and its pharmacological mechanism to protect liver injury by weakening the function of macrophages in septic livers through inhibiting NOD-like receptor protein 3 (NLRP3) inflammasome pathway.Method: In vivo experiments, septic mouse model was induced by cecal ligation and puncture (CLP), and then the mortality was detected, liver inflammatory damages and plasma biomarkers of liver injury were evaluated by histopathological staining and biochemical assays, respectively. In vitro experiments, mouse primary peritoneal macrophages were treated with lipopolysaccharide (LPS) and ATP, and then the activated-inflammasomes, macrophage migration and polarization were detected by ASC immunofluorescence staining, transwell and flow cytometry assays, respectively. NLRP3 inflammasome components NLRP3, caspase-1, IL-1β and IL-18 protein expressions were detected using western blot assays, and the contents of IL-1β and IL-18 were measured by ELISA assays.Results: POG treatment significantly decreased the mortality, liver inflammatory damages, hepatocyte apoptosis and plasma biomarkers of liver injury in CLP-challenged male WT mice, which were comparable to those in ibuprofen (a putative anti-inflammatory drug)-supplemented septic male WT mice and septic NLRP3 deficient-male mice. POG supplementation significantly suppressed NLRP3 inflammasome activation in septic liver tissues and cultured macrophages, by significantly reducing NLRP3, cleaved-caspase-1, IL-1β and IL-18 levels, the activated-inflammasome ASC specks, and macrophage infiltration and migration, as well as M1-like polarization, but significantly increasing M2-like polarization. These findings were similar to the pharmacological effects of ibuprofen, NLRP3 deficiency, and a special NLRP3 inhibitor, MCC950.Conclusion: POG protected against sepsis by inhibiting NLRP3 inflammasome-mediated macrophage activation in septic liver and attenuating liver inflammatory injury, indicating that it may be a potential anti-sepsis drug candidate. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca 2+ -dependent endoplasmic reticulum stress in VSMCs.

Author

Li RL, Zhuo CL, Yan X, Li H, Lin L, Li LY, Jiang Q, Zhang D, Wang XM, Liu LL, Huang WJ, Wang YL, Li XY, Mao Y, Chen Y, Liu X, Xu QC, Cai YY, Yang XJ, Chen HY, Wu SS, and Jiang W

Subjects
Mice, Male, Animals, Fibronectins metabolism, AMP-Activated Protein Kinases metabolism, Vascular Remodeling, Calcium metabolism, Muscle, Smooth, Vascular metabolism, Endoplasmic Reticulum Stress, Angiotensin II metabolism, Hypertension
Abstract

Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment. Irisin, a newly discovered myokine and adipokine, has been found to have beneficial effects on various cardiovascular diseases. However, the pharmacological effect of irisin in antagonizing hypertension-induced vascular remodeling is not well understood. In the present study, we investigated the protection and mechanisms of irisin against hypertension and vascular remodeling induced by angiotensin II (Ang II). Adult male mice of wild-type, FNDC5 (irisin-precursor) knockout, and FNDC5 overexpression were used to develop hypertension by challenging them with Ang II subcutaneously in the back using a microosmotic pump for 4 weeks. Similar to the attenuation of irisin on Ang II-induced VSMCs remodeling, endogenous FNDC5 ablation exacerbated, and exogenous FNDC5 overexpression alleviated Ang II-induced hypertension and vascular remodeling. Aortic RNA sequencing showed that irisin deficiency exacerbated intracellular calcium imbalance and increased vasoconstriction, which was parallel to the deterioration in both ER calcium dysmetabolism and ER stress. FNDC5 overexpression/exogenous irisin supplementation protected VSMCs from Ang II-induced remodeling by improving endoplasmic reticulum (ER) homeostasis. This improvement includes inhibiting Ca 2+ release from the ER and promoting the re-absorption of Ca 2+ into the ER, thus relieving Ca 2+ -dependent ER stress. Furthermore, irisin was confirmed to bind to its receptors, αV/β5 integrins, to further activate the AMPK pathway and inhibit the p38 pathway, leading to vasoprotection in Ang II-insulted VSMCs. These results indicate that irisin protects against hypertension and vascular remodeling in Ang II-challenged mice by restoring calcium homeostasis and attenuating ER stress in VSMCs via activating AMPK and suppressing p38 signaling., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

Published
2024
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43. Acupuncture for migraine prophylaxis: a randomized controlled trial.

Author

Li Y, Zheng H, Witt CM, Roll S, Yu SG, Yan J, Sun GJ, Zhao L, Huang WJ, Chang XR, Zhang HX, Wang DJ, Lan L, Zou R, and Liang FR

Subjects
Adult, Female, Follow-Up Studies, Humans, Male, Pain Measurement, Quality of Life, Retrospective Studies, Single-Blind Method, Treatment Outcome, Acupuncture Therapy methods, Migraine Disorders prevention & control
Abstract

Background: Acupuncture is commonly used to treat migraine. We assessed the efficacy of acupuncture at migraine-specific acupuncture points compared with other acupuncture points and sham acupuncture., Methods: We performed a multicentre, single-blind randomized controlled trial. In total, 480 patients with migraine were randomly assigned to one of four groups (Shaoyang-specific acupuncture, Shaoyang-nonspecific acupuncture, Yangming-specific acupuncture or sham acupuncture [control]). All groups received 20 treatments, which included electrical stimulation, over a period of four weeks. The primary outcome was the number of days with a migraine experienced during weeks 5-8 after randomization. Our secondary outcomes included the frequency of migraine attack, migraine intensity and migraine-specific quality of life., Results: Compared with patients in the control group, patients in the acupuncture groups reported fewer days with a migraine during weeks 5-8, however the differences between treatments were not significant (p > 0.05). There was a significant reduction in the number of days with a migraine during weeks 13-16 in all acupuncture groups compared with control (Shaoyang-specific acupuncture v. control: difference -1.06 [95% confidence interval (CI) -1.77 to -0.5], p = 0.003; Shaoyang-nonspecific acupuncture v. control: difference -1.22 [95% CI -1.92 to -0.52], p < 0.001; Yangming-specific acupuncture v. control: difference -0.91 [95% CI -1.61 to -0.21], p = 0.011). We found that there was a significant, but not clinically relevant, benefit for almost all secondary outcomes in the three acupuncture groups compared with the control group. We found no relevant differences between the three acupuncture groups., Interpretation: Acupuncture tested appeared to have a clinically minor effect on migraine prophylaxis compared with sham acupuncture., Trial Registration: Clinicaltrials.gov NCT00599586.

Published
2012
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