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1. Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child

Author

Lévy, Romain, Zhang, Peng, Bastard, Paul, Dorgham, Karim, Melki, Isabelle, Hadchouel, Alice, Hartoularos, George C., Neven, Bénédicte, Castelle, Martin, Roy, Charlotte, Toin, Tom, Berteloot, Laureline, Bizien, Lucy, Abid, Hanène, Burgard, Marianne, Houhou-Fidouh, Nadhira, Rozenberg, Flore, Jouanguy, Emmanuelle, Ye, Chun Jimmie, Gorochov, Guy, Zhang, Qian, and Casanova, Jean-Laurent

Published
2021

2. Clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection: an observational cohort study

Author

Mailhe, Morgane, Beaumont, Anne-Lise, Thy, Michael, Le Pluart, Diane, Perrineau, Ségolène, Houhou-Fidouh, Nadhira, Deconinck, Laurène, Bertin, Chloé, Ferré, Valentine Marie, Cortier, Marie, De La Porte Des Vaux, Clémentine, Phung, Bao-Chau, Mollo, Bastien, Cresta, Mélanie, Bouscarat, Fabrice, Choquet, Christophe, Descamps, Diane, Ghosn, Jade, Lescure, François-Xavier, Yazdanpanah, Yazdan, Joly, Véronique, and Peiffer-Smadja, Nathan

Published
2023
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4. Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Author

Bucciol, Giorgia, Moens, Leen, Ogishi, Masato, Rinchai, Darawan, Matuozzo, Daniela, Momenilandi, Mana, Kerrouche, Nacim, Cale, Catherine M., Treffeisen, Elsa R., Salamah, Mohammad Al, Saud, Bandar K. Al-, Lachaux, Alain, Duclaux-Loras, Remi, Meignien, Marie, Bousfiha, Aziz, Benhsaien, Ibtihal, Shcherbina, Anna, Roppelt, Anna, Gothe, Florian, Houhou-Fidouh, Nadhira, Hackett, Scott J., Bartnikas, Lisa M., Maciag, Michelle C., Alosaimi, Mohammed F., Chou, Janet, Mohammed, Reem W., Freij, Bishara J., Jouanguy, Emmanuelle, Zhang, Shen-Ying, Boisson-Dupuis, Stephanie, Beziat, Vivien, Zhang, Qian, Duncan, Christopher J.A., Hambleton, Sophie, Casanova, Jean- Laurent, and Meyts, Isabelle

Subjects
Genetic disorders -- Causes of -- Complications and side effects, Inflammation -- Genetic aspects -- Risk factors, STAT proteins -- Health aspects -- Genetic aspects, Virus diseases -- Risk factors -- Genetic aspects, Health care industry
Abstract

STAT2 is a transcription factor activated by type I and III IFNs. We report 23 patients with loss-of-function variants causing autosomal recessive (AR) complete STAT2 deficiency. Both cells transfected with mutant STAT2 alleles and the patients' cells displayed impaired expression of IFN-stimulated genes and impaired control of in vitro viral infections. Clinical manifestations from early childhood onward included severe adverse reaction to live attenuated viral vaccines (LAV) and severe viral infections, particularly critical influenza pneumonia, critical COVID-19 pneumonia, and herpes simplex virus type 1 (HSV-1) encephalitis. The patients displayed various types of hyperinflammation, often triggered by viral infection or after LAV administration, which probably attested to unresolved viral infection in the absence of STAT2-dependent types I and III IFN immunity. Transcriptomic analysis revealed that circulating monocytes, neutrophils, and [CD8.sup.+] memory T cells contributed to this inflammation. Several patients died from viral infection or heart failure during a febrile illness with no identified etiology. Notably, the highest mortality occurred during early childhood. These findings show that AR complete STAT2 deficiency underlay severe viral diseases and substantially impacts survival., Introduction Human type I and III IFNs operate in almost all cell types (1, 2). Type I IFNs (IFN-[alpha]/[beta]) are thought to be secreted by most, if not all, of [...]

Published
2023
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7. Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients

Author

Okba, Nisreen M.A., Muller, Marcel A., Li, Wentao, Wang, Chunyan, GeurtsvanKessel, Corine H., Corman, Victor M., Lamers, Mart M., Sikkema, Reina S., de Bruin, Erwin, Chandler, Felicity D., Yazdanpanah, Yazdan, Hingrat, Quentin Le, Descamps, Diane, Houhou-Fidouh, Nadhira, Reusken, Chantal B.E.M., Bosch, Berend-Jan, Drosten, Christian, Koopmans, Marion P.G., and Haagmans, Bart L.

Subjects
Severe acute respiratory syndrome -- Health aspects, Enzyme-linked immunosorbent assay -- Health aspects, Coronaviruses -- Health aspects, Medical research -- Health aspects, Immunoglobulin A -- Health aspects, Immunoglobulin G -- Health aspects, COVID-19 -- Health aspects, Health
Abstract

In December 2019, a new coronavirus emerged in China and caused an acute respiratory disease now known as coronavirus disease 2019 (COVID-19) (1). The virus was identified to be a [...]

Published
2020
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8. Earlier In Vitro Viral Production With SARS-CoV-2 Alpha Than With Beta, Gamma, B, or A.27 Variants

Author

Lebourgeois, Samuel, primary, Chenane, Houssem Redha, additional, Houhou-Fidouh, Nadhira, additional, Menidjel, Reyene, additional, Ferré, Valentine Marie, additional, Collin, Gilles, additional, Benmalek, Nabil, additional, Coppée, Romain, additional, Larrouy, Lucile, additional, Yazdanpanah, Yazdan, additional, Timsit, Jean-François, additional, Charpentier, Charlotte, additional, Descamps, Diane, additional, and Visseaux, Benoit, additional

Published
2021
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9. Corrigendum to ‘detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives’

Author

Le Hingrat, Quentin, primary, Visseaux, Benoit, additional, Laouenan, Cédric, additional, Tubiana, Sarah, additional, Bouadma, Lila, additional, Yazdanpanah, Yazdan, additional, Duval, Xavier, additional, Burdet, Charles, additional, Ichou, Houria, additional, Damond, Florence, additional, Bertine, Mélanie, additional, Benmalek, Nabil, additional, Choquet, Christophe, additional, Timsit, Jean-François, additional, Ghosn, Jade, additional, Charpentier, Charlotte, additional, Descamps, Diane, additional, and Houhou-Fidouh, Nadhira, additional

Published
2021
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12. Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives

Author

Le Hingrat, Quentin, primary, Visseaux, Benoit, additional, Laouenan, Cédric, additional, Tubiana, Sarah, additional, Bouadma, Lila, additional, Yazdanpanah, Yazdan, additional, Duval, Xavier, additional, Burdet, Charles, additional, Ichou, Houria, additional, Damond, Florence, additional, Bertine, Mélanie, additional, Benmalek, Nabil, additional, Choquet, Christophe, additional, Timsit, Jean-François, additional, Ghosn, Jade, additional, Charpentier, Charlotte, additional, Descamps, Diane, additional, Houhou-Fidouh, Nadhira, additional, Diallo, Alpha, additional, Le Mestre, Soizic, additional, Mercier, Noémie, additional, Paul, Christelle, additional, Petrov-Sanchez, Ventzislava, additional, Malvy, Denis, additional, Chirouze, Catherine, additional, Andrejak, Claire, additional, Dubos, François, additional, Rossignol, Patrick, additional, Picone, Olivier, additional, Bompart, François, additional, Gigante, Tristan, additional, Gilg, Morgane, additional, Rossignol, Bénédicte, additional, Levy-Marchal, Claire, additional, Beluze, Marine, additional, Hulot, Jean Sébastien, additional, Bachelet, Delphine, additional, Bhavsar, Krishna, additional, Chair, Anissa, additional, Couffignal, Camille, additional, Da Silveira, Charlene, additional, Debray, Marie Pierre, additional, Eloy, Philippine, additional, Esposito-Farese, Marina, additional, Ettalhaoui, Nadia, additional, Gault, Nathalie, additional, Gorenne, Isabelle, additional, Hoffmann, Isabelle, additional, Kafif, Ouifiya, additional, Kali, Sabrina, additional, Khalil, Antoine, additional, Laouénan, Cédric, additional, Laribi, Samira, additional, Le, Minh, additional, Le Hingrat, Quentin, additional, Lescure, François-Xavier, additional, Lucet, Jean Christophe, additional, Mentré, France, additional, Mullaert, Jimmy, additional, Peiffer-Smadja, Nathan, additional, Peytavin, Gilles, additional, Roy, Carine, additional, Schneider, Marion, additional, Mohammed, Nassima Si, additional, Tagherset, Lysa, additional, Tardivon, Coralie, additional, Tellier, Marie Capucine, additional, Trioux, Théo, additional, Vanel, Noémie, additional, Basmaci, Romain, additional, Angoulvant, François, additional, Kaguelidou, Florentia, additional, Pages, Justine, additional, Tual, Christelle, additional, Veislinger, Aurélie, additional, Couffin-Cardiergues, Sandrine, additional, Esperou, Hélène, additional, Houas, Ikram, additional, Jaafoura, Salma, additional, Papadopoulos, Aurélie, additional, Coelho, Alexandra, additional, Diouf, Alphonsine, additional, Hoctin, Alexandre, additional, Mambert, Marina, additional, Bouscambert, Maude, additional, Gaymard, Alexandre, additional, Lina, Bruno, additional, Rosa-Calatrava, Manuel, additional, Terrier, Olivier, additional, Benkerrou, Dehbia, additional, Dorival, Céline, additional, Meziane, Amina, additional, Téoulé, François, additional, Guedj, Jérémie, additional, Le Nagard, Hervé, additional, Lingas, Guillaume, additional, Neant, Nadège, additional, Abel, Laurent, additional, Desvallée, Mathilde, additional, Khan, Coralie, additional, Deplanque, Dominique, additional, Behilill, Sylvie, additional, Enouf, Vincent, additional, Mouquet, Hugo, additional, Van Der Werf, Sylvie, additional, Cervantes-Gonzalez, Minerva, additional, D'ortenzio, Eric, additional, Puéchal, Oriane, additional, Semaille, Caroline, additional, Noret, Marion, additional, Etienne, Manuel, additional, Levy, Yves, additional, and Wiedemann, Aurélie, additional

Published
2021
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13. Viral epidemiology and SARS‐CoV‐2 co‐infections with other respiratory viruses during the first COVID‐19 wave in Paris, France

Author

Le Hingrat, Quentin, primary, Bouzid, Donia, additional, Choquet, Christophe, additional, Laurent, Odile, additional, Lescure, François‐Xavier, additional, Timsit, Jean‐François, additional, Houhou‐Fidouh, Nadhira, additional, Casalino, Enrique, additional, Lucet, Jean‐Christophe, additional, Descamps, Diane, additional, and Visseaux, Benoit, additional

Published
2021
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15. Case reports study of the first five patients COVID-19 treated with remdesivir in France

Author

Dubert, Marie, Visseaux, Benoit, Isernia, Valentina, Bouadma, Lila, Deconinck, Laurène, Patrier, Juliette, Wicky, Paul-Henri, Le Pluart, Diane, Kramer, Laura, Rioux, Christophe, Le Hingrat, Quentin, Houhou-Fidouh, Nadhira, Yazdanpanah, Yazdan, Ghosn, Jade, and Lescure, Francois-Xavier

Subjects
SARS-CoV-2 viral load, UNL, upper normal limit, HIV-1, Human immunodeficiency virus 1, antiviral therapy, case reports, VL, viral load, viral pneumonia, remdesivir, ICU, intensive care unit, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article
Abstract

Highlights • Remdesivir has been found to be an in-vitro potent inhibitor of RNA viruses including SARS-CoV-2 but its in-vivo potency is still under active investigations. • In this work, we depict the clinical features of 5 hospitalized COVID-19 patients under remdisivir compassionate use. • Remdisivir infusion was associated with decreasing viral loads from nasopharyngeal samples despite active replication in the lower respiratory tract area evidenced for two patients. • The treatment had to be interrupted for potential side effects for 4 out 5 patients including two alamine aminotransferase (ALT) elevation and two renal failure cases., The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as responsible for the COVID-19 outbreak worldwide. Data on treatment are scare and parallels are made between SARS-CoV-2 and other coronavirus. Remdesivir is a broad spectrum antiviral with efficient in vitro activity against SARS-CoV-2 and controversial evidence of clinical improvement in severe COVID-19 patients. We aimed to describe the clinical outcome and virological monitoring of the first five COVID-19 patients admitted in ICU for severe pneumonia related to SARS-CoV-2 and treated with remdesivir in the University hospital of Bichat, Paris, France. SARS-CoV-2 RT-qPCR in blood plasma, lower and upper respiratory tract were monitored. Among the five treated patients, two needed mechanical ventilation and one high flow cannula oxygen. A significant decrease in SARS-CoV-2 viral load from upper respiratory tract was observed in most cases but two died with active SARS-CoV-2 replication in the lower respiratory tract. Plasma samples were positive for SARS-CoV-2 in only one patient. Remdesivir was interrupted for side effects among four patients, including 2 ALT elevations (3 to 5 N) and 2 renal failures requiring renal replacement. This case series of five COVID-19 patients requiring ICU for a respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients.

Published
2020

16. Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients

Author

Virologie, dI&I I&I-1, Okba, Nisreen M A, Müller, Marcel A, Li, Wentao, Wang, Chunyan, GeurtsvanKessel, Corine H, Corman, Victor M, Lamers, Mart M, Sikkema, Reina S, de Bruin, Erwin, Chandler, Felicity D, Yazdanpanah, Yazdan, Le Hingrat, Quentin, Descamps, Diane, Houhou-Fidouh, Nadhira, Reusken, Chantal B E M, Bosch, Berend-Jan, Drosten, Christian, Koopmans, Marion P G, Haagmans, Bart L, Virologie, dI&I I&I-1, Okba, Nisreen M A, Müller, Marcel A, Li, Wentao, Wang, Chunyan, GeurtsvanKessel, Corine H, Corman, Victor M, Lamers, Mart M, Sikkema, Reina S, de Bruin, Erwin, Chandler, Felicity D, Yazdanpanah, Yazdan, Le Hingrat, Quentin, Descamps, Diane, Houhou-Fidouh, Nadhira, Reusken, Chantal B E M, Bosch, Berend-Jan, Drosten, Christian, Koopmans, Marion P G, and Haagmans, Bart L

Published
2020

17. Case report study of the first five COVID-19 patients treated with remdesivir in France

Author

Dubert, Marie, primary, Visseaux, Benoit, additional, Isernia, Valentina, additional, Bouadma, Lila, additional, Deconinck, Laurène, additional, Patrier, Juliette, additional, Wicky, Paul-Henri, additional, Le Pluart, Diane, additional, Kramer, Laura, additional, Rioux, Christophe, additional, Le Hingrat, Quentin, additional, Houhou-Fidouh, Nadhira, additional, Yazdanpanah, Yazdan, additional, Ghosn, Jade, additional, and Lescure, Francois-Xavier, additional

Published
2020
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18. Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the First Rapid Multiplex PCR Commercial Assay for SARS-CoV-2 Detection

Author

Visseaux, Benoit, primary, Le Hingrat, Quentin, additional, Collin, Gilles, additional, Bouzid, Donia, additional, Lebourgeois, Samuel, additional, Le Pluart, Diane, additional, Deconinck, Laurène, additional, Lescure, François-Xavier, additional, Lucet, Jean-Christophe, additional, Bouadma, Lila, additional, Timsit, Jean-François, additional, Descamps, Diane, additional, Yazdanpanah, Yazdan, additional, Casalino, Enrique, additional, and Houhou-Fidouh, Nadhira, additional

Published
2020
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19. Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients

Author

Okba, Nisreen M.A., primary, Müller, Marcel A., additional, Li, Wentao, additional, Wang, Chunyan, additional, GeurtsvanKessel, Corine H., additional, Corman, Victor M., additional, Lamers, Mart M., additional, Sikkema, Reina S., additional, de Bruin, Erwin, additional, Chandler, Felicity D., additional, Yazdanpanah, Yazdan, additional, Le Hingrat, Quentin, additional, Descamps, Diane, additional, Houhou-Fidouh, Nadhira, additional, Reusken, Chantal B.E.M., additional, Bosch, Berend-Jan, additional, Drosten, Christian, additional, Koopmans, Marion P.G., additional, and Haagmans, Bart L., additional

Published
2020
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20. Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives

Author

Diallo, Alpha, Le Mestre, Soizic, Mercier, Noémie, Paul, Christelle, Petrov-Sanchez, Ventzislava, Malvy, Denis, Chirouze, Catherine, Andrejak, Claire, Dubos, François, Rossignol, Patrick, Picone, Olivier, Bompart, François, Gigante, Tristan, Gilg, Morgane, Rossignol, Bénédicte, Levy-Marchal, Claire, Beluze, Marine, Hulot, Jean Sébastien, Bachelet, Delphine, Bhavsar, Krishna, Bouadma, Lila, Chair, Anissa, Couffignal, Camille, Da Silveira, Charlene, Debray, Marie Pierre, Descamps, Diane, Duval, Xavier, Eloy, Philippine, Esposito-Farese, Marina, Ettalhaoui, Nadia, Gault, Nathalie, Ghosn, Jade, Gorenne, Isabelle, Hoffmann, Isabelle, Kafif, Ouifiya, Kali, Sabrina, Khalil, Antoine, Laouénan, Cédric, Laribi, Samira, Le, Minh, Le Hingrat, Quentin, Lescure, François-Xavier, Lucet, Jean Christophe, Mentré, France, Mullaert, Jimmy, Peiffer-Smadja, Nathan, Peytavin, Gilles, Roy, Carine, Schneider, Marion, Mohammed, Nassima Si, Tagherset, Lysa, Tardivon, Coralie, Tellier, Marie Capucine, Timsit, Jean-François, Trioux, Théo, Tubiana, Sarah, Visseaux, Benoit, Vanel, Noémie, Basmaci, Romain, Angoulvant, François, Kaguelidou, Florentia, Pages, Justine, Tual, Christelle, Veislinger, Aurélie, Couffin-Cardiergues, Sandrine, Esperou, Hélène, Houas, Ikram, Jaafoura, Salma, Papadopoulos, Aurélie, Coelho, Alexandra, Diouf, Alphonsine, Hoctin, Alexandre, Mambert, Marina, Bouscambert, Maude, Gaymard, Alexandre, Lina, Bruno, Rosa-Calatrava, Manuel, Terrier, Olivier, Benkerrou, Dehbia, Dorival, Céline, Meziane, Amina, Téoulé, François, Guedj, Jérémie, Le Nagard, Hervé, Lingas, Guillaume, Neant, Nadège, Abel, Laurent, Desvallée, Mathilde, Khan, Coralie, Deplanque, Dominique, Yazdanpanah, Yazdan, Behilill, Sylvie, Enouf, Vincent, Mouquet, Hugo, Van Der Werf, Sylvie, Cervantes-Gonzalez, Minerva, D'ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Noret, Marion, Etienne, Manuel, Levy, Yves, Wiedemann, Aurélie, Laouenan, Cédric, Burdet, Charles, Ichou, Houria, Damond, Florence, Bertine, Mélanie, Benmalek, Nabil, Choquet, Christophe, Charpentier, Charlotte, and Houhou-Fidouh, Nadhira

Published
2021
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21. Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016

Author

Visseaux, Benoit, Burdet, Charles, Voiriot, Guillaume, Lescure, François-Xavier, Chougar, Taous, Brugière, Olivier, Crestani, Bruno, Casalino, Enrique, Charpentier, Charlotte, Descamps, Diane, Timsit, Jean-François, Yazdanpanah, Yazdan, and Houhou-Fidouh, Nadhira

Subjects
0301 basic medicine, RNA viruses, Male, Pediatrics, Influenza Viruses, Viral Diseases, Pulmonology, Coronaviruses, Nosocomial Infections, viruses, lcsh:Medicine, Picornaviridae, medicine.disease_cause, Pathology and Laboratory Medicine, law.invention, 0302 clinical medicine, law, Epidemiology, Medicine and Health Sciences, Prevalence, 030212 general & internal medicine, lcsh:Science, Respiratory Tract Infections, Aged, 80 and over, Multidisciplinary, Respiratory tract infections, Age Factors, Middle Aged, Orthomyxoviridae, Intensive care unit, 3. Good health, Intensive Care Units, medicine.anatomical_structure, Infectious Diseases, Medical Microbiology, Viral Pathogens, Viruses, RNA, Viral, Female, France, Seasons, Rhinovirus, Pathogens, Research Article, Adult, medicine.medical_specialty, 030106 microbiology, Picornaviruses, Microbiology, Adenoviridae, 03 medical and health sciences, Young Adult, Intensive care, Internal medicine, medicine, Humans, Microbial Pathogens, Aged, Biology and life sciences, business.industry, lcsh:R, Organisms, Influenza, Age Groups, People and Places, DNA, Viral, Enterovirus, lcsh:Q, Population Groupings, business, Multiplex Polymerase Chain Reaction, Respiratory tract, Orthomyxoviruses
Abstract

Background Multiplex PCR tests have improved our understanding of respiratory viruses' epidemiology by allowing their wide range detection. We describe here the burden of these viruses in hospital settings over a five-year period. Methods All respiratory samples from adult patients (>20 years old) tested by multiplex-PCR at the request of physicians, from May 1 2011 to April 30 2016, were included retrospectively. Viral findings are reported by season, patient age group, respiratory tract region (upper or lower) and type of clinical unit (intensive care unit, pneumology unit, lung transplantation unit and other medical units). Results In total, 7196 samples (4958 patients) were included; 29.2% tested positive, with viral co-infections detected in 1.6% of samples. Overall, two viral groups accounted for 60.2% of all viruses identified: picornaviruses (rhinovirus or enterovirus, 34.3%) and influenza (26.6%). Influenza viruses constituted the group most frequently identified in winter (34.4%), in the upper respiratory tract (32%) and in patients over the age of 70 years (36.4%). Picornavirus was the second most frequently identified viral group in these populations and in all other groups, including lower respiratory tract infections (41.3%) or patients in intensive care units (37.6%). Conclusion This study, the largest to date in Europe, provides a broad picture of the distribution of viruses over seasons, age groups, types of clinical unit and respiratory tract regions in the hospital setting. It highlights the burden associated with the neglected picornavirus group. These data have important implications for the future development of vaccines and antiviral drugs.

Published
2017

22. Usefulness of multiplex PCR methods and respiratory viruses’ distribution in children below 15 years old according to age, seasons and clinical units in France: A 3 years retrospective study

Author

Visseaux, Benoit, Collin, Gilles, Ichou, Houria, Charpentier, Charlotte, Bendhafer, Samia, Dumitrescu, Madalina, Allal, Lahcene, Cojocaru, Bogdan, Desfrère, Luc, Descamps, Diane, Mandelbrot, Laurent, and Houhou-Fidouh, Nadhira

Subjects
RNA viruses, Male, 0301 basic medicine, Influenza Viruses, Viral Diseases, Adenoviruses, Pediatrics, Pulmonology, Coronaviruses, viruses, lcsh:Medicine, Virus diseases, Pathology and Laboratory Medicine, 0302 clinical medicine, Nasopharynx, Medicine and Health Sciences, Medicine, Respiratory system, Child, lcsh:Science, Respiratory Tract Infections, Multidisciplinary, Respiratory tract infections, Respiratory Syncytial Viruses, 3. Good health, Infectious Diseases, Medical Microbiology, Virus Diseases, Viral Pathogens, Child, Preschool, Viruses, Female, Pediatric Pulmonology, France, Seasons, Pathogens, Research Article, medicine.medical_specialty, Adolescent, Specific detection, 030106 microbiology, Respiratory Syncytial Virus Infections, Microbiology, 03 medical and health sciences, Parvoviruses, Adeno-Associated Viruses, 030225 pediatrics, Multiplex polymerase chain reaction, Humans, Microbial Pathogens, Retrospective Studies, Biology and life sciences, business.industry, lcsh:R, Organisms, Infant, Retrospective cohort study, Influenza, Co-Infections, lcsh:Q, DNA viruses, business, Multiplex Polymerase Chain Reaction, Orthomyxoviruses, Co infection
Abstract

Background To date, only influenza and RSV testing are recommended for respiratory viruses’ detection in paediatric units. In this study, we described, according to seasons, ages and clinical units, the results obtained in children (

Published
2017
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23. Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia

Author

Voiriot, Guillaume, primary, Visseaux, Benoit, additional, Cohen, Johana, additional, Nguyen, Liem Binh Luong, additional, Neuville, Mathilde, additional, Morbieu, Caroline, additional, Burdet, Charles, additional, Radjou, Aguila, additional, Lescure, François-Xavier, additional, Smonig, Roland, additional, Armand-Lefèvre, Laurence, additional, Mourvillier, Bruno, additional, Yazdanpanah, Yazdan, additional, Soubirou, Jean-Francois, additional, Ruckly, Stephane, additional, Houhou-Fidouh, Nadhira, additional, and Timsit, Jean-François, additional

Published
2016
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24. Additional file 1 of HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients

Author

Meyer, Antoine, Buetti, Niccol��, Houhou-Fidouh, Nadhira, Patrier, Juliette, Abdel-Nabey, Moustafa, Jaquet, Pierre, Presente, Simona, Girard, Tiphaine, Sayagh, Faiza, Ruckly, Stephane, Wicky, Paul-Henri, de Montmollin, Etienne, Bouadma, Lila, Sonneville, Romain, Descamps, Diane, and Timsit, Jean-Francois

Subjects
3. Good health
Abstract

Additional file 1. Table E1. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60. Table E2. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60 in respiratory samples. Table E3. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60 in blood samples. Table E4. Univariable and multivariable cause specific models investigating the association between HSV-1 reactivation and HAP/VAP. Table E5. Univariable and multivariable cause specific models investigating the association between HSV-1 reactivation in blood and HAP/VAP.

25. Additional file 1 of HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients

Author

Meyer, Antoine, Buetti, Niccol��, Houhou-Fidouh, Nadhira, Patrier, Juliette, Abdel-Nabey, Moustafa, Jaquet, Pierre, Presente, Simona, Girard, Tiphaine, Sayagh, Faiza, Ruckly, Stephane, Wicky, Paul-Henri, de Montmollin, Etienne, Bouadma, Lila, Sonneville, Romain, Descamps, Diane, and Timsit, Jean-Francois

Subjects
3. Good health
Abstract

Additional file 1. Table E1. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60. Table E2. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60 in respiratory samples. Table E3. Univariable and multivariable Cox models investigating the association between HSV-1 reactivation and mortality at day 60 in blood samples. Table E4. Univariable and multivariable cause specific models investigating the association between HSV-1 reactivation and HAP/VAP. Table E5. Univariable and multivariable cause specific models investigating the association between HSV-1 reactivation in blood and HAP/VAP.

26. Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives.

Author

Hingrat QL, Visseaux B, Laouenan C, Tubiana S, Bouadma L, Yazdanpanah Y, Duval X, Burdet C, Ichou H, Damond F, Bertine M, Benmalek N, Choquet C, Timsit JF, Ghosn J, Charpentier C, Descamps D, and Houhou-Fidouh N

Abstract

Objectives: Molecular assays on nasopharyngeal swabs remain the cornerstone of COVID-19 diagnostic. The high technicalities of nasopharyngeal sampling and molecular assays, as well as scarce resources of reagents, limit our testing capabilities. Several strategies failed, to date, to fully alleviate this testing process (e.g. saliva sampling or antigen testing on nasopharyngeal samples). We assessed the clinical performances of SARS-CoV-2 nucleocapsid antigen (N-antigen) ELISA detection in serum or plasma using the COVID-19 Quantigene® (AAZ, France) assay., Methods: Performances were determined on 63 sera from 63 non-COVID patients and 227 serum samples (165 patients) from the French COVID and CoV-CONTACT cohorts with RT-PCR confirmed SARS-CoV-2 infection, including 142 serum (114 patients) obtained within 14 days after symptoms' onset., Results: Specificity was 98.4% (95% confidence interval [CI], 95.3 to 100). Sensitivity was 79.3% overall (180/227, 95% CI, 74.0 to 84.6) and 93.0% (132/142, 95% CI, 88.7 to 97.2) within 14 days after symptoms onset. 91 included patients had a sera and nasopharyngeal swabs collected in the same 24 hours. Among those with high nasopharyngeal viral loads, i.e. Ct value below 30 and 33, only 1/50 and 4/67 tested negative for N-antigenemia, respectively. Among those with a negative nasopharyngeal RT-PCR, 8/12 presented positive N-antigenemia; the lower respiratory tract was explored for 6 of these 8 patients, showing positive RT-PCR in 5 cases., Conclusion: This is the first evaluation of a commercially available serum N-antigen detection assay. It presents a robust specificity and sensitivity within the first 14 days after symptoms onset. This approach provides a valuable new option for COVID-19 diagnosis, only requiring a blood draw and easily scalable in all clinical laboratories., (Copyright © 2020. Published by Elsevier Ltd.)

Published
2020
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