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2. Author Correction: Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer

Author

Foldi, Julia, Silber, Andrea, Reisenbichler, Emily, Singh, Kamaljeet, Fischbach, Neal, Persico, Justin, Adelson, Kerin, Katoch, Anamika, Horowitz, Nina, Lannin, Donald, Chagpar, Anees, Park, Tristen, Marczyk, Michal, Frederick, Courtney, Burrello, Trisha, Ibrahim, Eiman, Qing, Tao, Bai, Yalai, Blenman, Kim, Rimm, David L., and Pusztai, Lajos

Published
2022
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3. Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer

Author

Foldi, Julia, Silber, Andrea, Reisenbichler, Emily, Singh, Kamaljeet, Fischbach, Neal, Persico, Justin, Adelson, Kerin, Katoch, Anamika, Horowitz, Nina, Lannin, Donald, Chagpar, Anees, Park, Tristen, Marczyk, Michal, Frederick, Courtney, Burrello, Trisha, Ibrahim, Eiman, Qing, Tao, Bai, Yalai, Blenman, Kim, Rimm, David L., and Pusztai, Lajos

Published
2021
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4. A PHASE II TRIAL OF BALLOON-CATHETER PARTIAL BREAST BRACHYTHERAPY OPTIMIZATION IN THE TREATMENT OF STAGE 0, I AND IIA BREAST CARCINOMA.

Author

Nath, Sameer K, Chen, Zhe J, Rowe, Bryan P, Blitzblau, Rachel C, Aneja, Sanjay, Grube, Baiba J, Horowitz, Nina R, and Weidhaas, Joanne B

Subjects
MammoSite, accelerated partial breast irradiation, brachytherapy, breast cancer, skin toxicity
Abstract

Objectives(a) To prospectively determine if multidwell position dose delivery can decrease skin dose and resultant toxicity over single dwell balloon-catheter partial breast irradiation, and (b) to evaluate whether specific skin parameters could be safely used instead of skin-balloon distance alone for predicting toxicity and treatment eligibility.MethodsA single-arm phase II study using a Simon two-stage design was performed on 28 women with stage 0-II breast cancer. All patients were treated with multiple dwell position balloon-catheter brachytherapy. The primary endpoint was ≥ grade 2 skin toxicity. Initial entry required a balloon-skin distance ≥ 7 mm. Based on the toxicity in the first 16 patients, additional patients were treated irrespective of skin-balloon distance as long as the Dmax to 1 mm skin thickness was < 130%.ResultsCompared to the phantom single dwell plans, multidwell planning yielded superior PTV coverage as per median V90, V95 and V100, but had slightly worse V150, V200 and DHI. Dmax to skin was decreased by multidwell planning at multiple skin thicknesses. The most common acute toxicity was grade 1 erythema (57%), and only two patients (7%) developed acute grade 2 toxicity (erythema). Late grade 1 fibrosis was seen in 32%. No patients experienced grade 3, 4, or 5 toxicity.ConclusionsMultidwell position planning for balloon-catheter brachytherapy results in lower skin doses with equal to superior PTV coverage and an overall low rate of initial skin toxicity. Our data suggest that limiting the Dmax to < 130% to 1 mm thick skin is achievable and results in minimal toxicity.

Published
2014

9. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients

Author

Trant, Amelia A., primary, Chagpar, Anees, additional, Wei, Wei, additional, Neumeister, Veronique, additional, Rimm, David, additional, Stavris, Karen, additional, Lurie, Bonnie, additional, Frederick, Courtney, additional, Andrejeva, Liva, additional, Raghu, Madhavi, additional, Killelea, Brigid, additional, Horowitz, Nina, additional, Lannin, Donald, additional, Knill-Selby, Elspeth, additional, Sturrock, Tracy, additional, and Hofstatter, Erin, additional

Published
2022
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10. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging

Author

Lu, Darlene, primary, Demissie, Serkalem, additional, Horowitz, Nina B, additional, Gower, Adam C, additional, Lenburg, Marc E, additional, Alekseyev, Yuriy O, additional, Hussein, Amira I, additional, Bragdon, Beth, additional, Liu, Yu, additional, Daukss, Dana, additional, Page, Jack M, additional, Webster, Micheal Z, additional, Schlezinger, Jennifer J, additional, Morgan, Elise F, additional, and Gerstenfeld, Louis C, additional

Published
2021
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14. Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment

Author

Moreno-Nieves, Uriel Y., primary, Tay, Joshua K., additional, Saumyaa, Saumyaa, additional, Horowitz, Nina B., additional, Shin, June Ho, additional, Mohammad, Imran A., additional, Luca, Bogdan, additional, Mundy, David C., additional, Gulati, Gunsagar S., additional, Bedi, Nikita, additional, Chang, Serena, additional, Chen, Chen, additional, Kaplan, Michael J., additional, Rosenthal, Eben L., additional, Holsinger, F. Christopher, additional, Divi, Vasu, additional, Baik, Fred M., additional, Sirjani, Davud B., additional, Gentles, Andrew J., additional, Newman, Aaron M., additional, Freud, Aharon G., additional, and Sunwoo, John B., additional

Published
2021
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16. Abstract PD1-01: Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC)

Author

Pusztai, Lajos, primary, Reisenbichler, Emily, additional, Bai, Yailai, additional, Fischbach, Neal, additional, Persico, Justin, additional, Adelson, Kerin, additional, Katoch, Anamika, additional, Horowitz, Nina, additional, Lannin, Donald, additional, Killelea, Brigid, additional, Chagpar, Anees, additional, Frederick, Courtney, additional, Burello, Trisha, additional, Blenman, Kim, additional, Rimm, David, additional, and Silber, Andrea, additional

Published
2020
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17. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging.

Author

Lu, Darlene, Demissie, Serkalem, Horowitz, Nina B, Gower, Adam C, Lenburg, Marc E, Alekseyev, Yuriy O, Hussein, Amira I, Bragdon, Beth, Liu, Yu, Daukss, Dana, Page, Jack M, Webster, Micheal Z, Schlezinger, Jennifer J, Morgan, Elise F, and Gerstenfeld, Louis C

Subjects
SEXUAL dimorphism, TRANSCRIPTOMES, BONE growth, GENE expression, CONNECTIVE tissues, CELL populations, CALCIFICATION
Abstract

Time is a central element of the sexual dimorphic patterns of development, pathology, and aging of the skeleton. Because the transcriptome is a representation of the phenome, we hypothesized that both sex and sex‐specific temporal, transcriptomic differences in bone tissues over an 18‐month period would be informative to the underlying molecular processes that lead to postnatal sexual dimorphism. Regardless of age, sex‐associated changes of the whole bone transcriptomes were primarily associated not only with bone but also vascular and connective tissue ontologies. A pattern‐based approach used to screen the entire Gene Expression Omnibus (GEO) database against those that were sex‐specific in bone identified two coordinately regulated gene sets: one related to high phosphate–induced aortic calcification and one induced by mechanical stimulation in bone. Temporal clustering of the transcriptome identified two skeletal tissue‐associated, sex‐specific patterns of gene expression. One set of genes, associated with skeletal patterning and morphology, showed peak expression earlier in females. The second set of genes, associated with coupled remodeling, had quantitatively higher expression in females and exhibited a broad peak between 3 to 12 months, concurrent with the animals' reproductive period. Results of phenome‐level structural assessments of the tibia and vertebrae, and in vivo and in vitro analysis of cells having osteogenic potential, were consistent with the existence of functionally unique, skeletogenic cell populations that are separately responsible for appositional growth and intramedullary functions. These data suggest that skeletal sexual dimorphism arises through sex‐specific, temporally different processes controlling morphometric growth and later coupled remodeling of the skeleton during the reproductive period of the animal. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Long-Term Survival of De Novo Stage IV Human Epidermal Growth Receptor 2 (HER2) Positive Breast Cancers Treated with HER2-Targeted Therapy

Author

Wong, Yao, primary, Raghavendra, Akshara Singareeka, additional, Hatzis, Christos, additional, Irizarry, Javier Perez, additional, Vega, Teresita, additional, Horowitz, Nina, additional, Barcenas, Carlos H., additional, Chavez-MacGregor, Mariana, additional, Valero, Vicente, additional, Tripathy, Debu, additional, Pusztai, Lajos, additional, and Murthy, Rashmi K., additional

Published
2018
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21. Long‐Term Survival of De Novo Stage IV Human Epidermal Growth Receptor 2 (HER2) Positive Breast Cancers Treated with HER2‐Targeted Therapy.

Author

Wong, Yao, Raghavendra, Akshara Singareeka, Hatzis, Christos, Irizarry, Javier Perez, Vega, Teresita, Horowitz, Nina, Barcenas, Carlos H., Chavez‐MacGregor, Mariana, Valero, Vicente, Tripathy, Debu, Pusztai, Lajos, and Murthy, Rashmi K.

Subjects
TRASTUZUMAB, EPIDERMAL growth factor, BREAST tumors, CANCER patients, CONFIDENCE intervals, ESTROGEN receptors, MONOCLONAL antibodies, MULTIVARIATE analysis, SURVIVAL, TUMOR classification, DESCRIPTIVE statistics, THERAPEUTICS
Abstract

Copyright of Oncologist is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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23. Abstract PD3-4: Reliability of whole exome sequencing for assessing intratumor heterogeneity from breast tumor biopsies

Author

Shi, Weiwei, primary, Chagpar, Anees, additional, Jiang, Tingting, additional, Lannin, Donald R, additional, Killelea, Brigid, additional, Horowitz, Nina, additional, Lim, Raymond, additional, Platt, James, additional, Ng, Charlotte KY, additional, Wali, Vikram B, additional, Weigelt, Britta, additional, Reis-Filho, Jorge S, additional, Hatzis, Christos, additional, and Pusztai, Lajos, additional

Published
2015
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