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12 results on '"Hong, Huiqi"'

1. Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer

Author

Tay, Daryl Jin Tai, Song, Yangyang, Peng, Boya, Toh, Tan Boon, Hooi, Lissa, Toh, Desiree-Faye Kaixin, Hong, HuiQi, Tang, Sze Jing, Han, Jian, Gan, Wei Liang, Chan, Tim Hon Man, Krishna, Manchugondanahalli S., Patil, Kiran M., Maraswami, Manikantha, Loh, Teck Peng, Dan, Yock Young, Zhou, Lei, Bonney, Glenn Kunnath, Chow, Pierce Kah-Hoe, Chen, Gang, Chow, Edward Kai-Hua, Le, Minh T.N., and Chen, Leilei

Published
2021
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6. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression

Author

Han, Jian, primary, An, Omer, additional, Hong, HuiQi, additional, Chan, Tim Hon Man, additional, Song, Yangyang, additional, Shen, Haoqing, additional, Tang, Sze Jing, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Tay, Daryl Jin Tai, additional, Molias, Fernando Bellido, additional, Pitcheshwar, Priyankaa, additional, Tan, Hui Qing, additional, Yang, Henry, additional, and Chen, Leilei, additional

Published
2020
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7. Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer

Author

Hong, HuiQi, primary, An, Omer, additional, Chan, Tim H M, additional, Ng, Vanessa H E, additional, Kwok, Hui Si, additional, Lin, Jaymie S, additional, Qi, Lihua, additional, Han, Jian, additional, Tay, Daryl J T, additional, Tang, Sze Jing, additional, Yang, Henry, additional, Song, Yangyang, additional, Bellido Molias, Fernando, additional, Tenen, Daniel G, additional, and Chen, Leilei, additional

Published
2018
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8. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Author

Qi, Lihua, primary, Song, Yangyang, additional, Chan, Tim Hon Man, additional, Yang, Henry, additional, Lin, Chi Ho, additional, Tay, Daryl Jin Tai, additional, Hong, HuiQi, additional, Tang, Sze Jing, additional, Tan, Kar Tong, additional, Huang, Xi Xiao, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Maury, Julien Jean Pierre, additional, Tenen, Daniel G., additional, and Chen, Leilei, additional

Published
2017
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10. ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer

Author

Chan, Tim Hon Man, primary, Qamra, Aditi, additional, Tan, Kar Tong, additional, Guo, Jing, additional, Yang, Henry, additional, Qi, Lihua, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Song, Yangyang, additional, Hong, Huiqi, additional, Tay, Su Ting, additional, Liu, Yujing, additional, Lee, Jeeyun, additional, Rha, Sun Yong, additional, Zhu, Feng, additional, So, Jimmy Bok Yan, additional, Teh, Bin Tean, additional, Yeoh, Khay Guan, additional, Rozen, Steve, additional, Tenen, Daniel G., additional, Tan, Patrick, additional, and Chen, Leilei, additional

Published
2016
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12. Targeting RNA Editing of Antizyme Inhibitor1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer

Author

Tai Tay, Daryl Jin, Song, Yangyang, Peng, Boya, Toh, Tan Boon, Hooi, Lissa, Kaixin Toh, Desiree-Faye, Hong, HuiQi, Tang, Sze Jing, Han, Jian, Gan, Wei Liang, Man Chan, Tim Hon, Krishna, Manchugondanahalli S., Patil, Kiran M., Maraswami, Manikantha, Loh, Teck Peng, Dan, Yock Young, Zhou, Lei, Bonney, Glenn Kunnath, Kah-Hoe Chow, Pierce, Chen, Gang, Kai-Hua Chow, Edward, Le, Minh TN., and Chen, Leilei

Abstract

Dysregulated adenosine-to-inosine (A-to-I) RNA editing is implicated in various cancers. However, no available RNA editing inhibitors have so far been developed to inhibit cancer-associated RNA editing events. Here we decipher the RNA secondary structure of antizyme inhibitor 1(AZIN1), one of the best-studied A-to-I editing targets in cancer, by locating its editing site complementary sequence (ECS) at the 3’end of exon 12. Chemically modified antisense oligonucleotides (ASOs) which target the editing region of AZIN1caused a substantial exon 11 skipping; while ECS-targeting ASOs effectively abolish AZIN1editing without affecting splicing and translation. We demonstrate that complete 2′-O-methyl (2’-O-Me) sugar ring modification in combination with partial phosphorothioate (PS) backbone modification may be an optimal chemistry for editing inhibition. ASO3.2, which targets the ECS, specifically inhibits cancer cell viability in vitroand tumor incidence and growth in xenograft models. Our results demonstrate that this AZIN1-targeting, ASO-based therapeutics may be applicable to a wide range of tumor types.

Published
2021
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