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6 results on '"Honda, Fumi"'

2. Assessment of Outcome of Hepatic Arterial Infusion Chemotherapy in Patients with Advanced Hepatocellular Carcinoma by the Combination of RECIST and Tumor Markers

Author

Hatooka, Masahiro, Kawaoka, Tomokazu, Aikata, Hiroshi, Honda, Fumi, Nakamura, Yuki, Nakano, Norihito, Morio, Kei, Fukuhara, Takayuki, Kobayashi, Tomoki, Nagaoki, Yuko, Tsuge, Masataka, Hiramatsu, Akira, Imamura, Michio, Kawakami, Yoshiiku, Awai, Kazuo, and Chayama, Kazuaki

Subjects
RECIST, Hepatocellular carcinoma, Tumor marker, Hepatic arterial infusion chemotherapy, digestive system diseases
Abstract

To assess the outcome of stable disease (SD) patients with advanced hepatocellular carcinoma (HCC) by tumor markers after the first course of hepatic arterial infusion chemotherapy (HAIC). The study subjects were 156 HCC patients treated with HAIC and classified as Child Pugh A, with no extrahepatic metastasis, and no history of sorafenib treatment. In the study and validation cohorts, the AFP and DCP ratios of patients who were considered SD to the first course of HAIC were analyzed by AUROC for a prediction of response to the second course of HAIC. The imaging response to the first course of HAIC was classified as partial response (PR), SD and progressive disease (PD) in 29 (18.8%), 80 (51.9%), and 44 (28.6%) patients respectively. For SD patients, the α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) ratios of patients who were considered SD to the first course of HAIC were analyzed by the receiver operating characteristic curve for prediction of response to the second course of HAIC in the study cohorts. The area under the curve of AFP ratio was 0.743. The area under the curve of DCP ratio was 0.695. The cut-off values of AFP and DCP ratios were 1.3 and 1.0, respectively. In the validation cohort, the accuracy of the prediction of response in this validation cohort (71.4%) showed no significant difference compared to that in the study cohort (72.4%) (p = 1.0). The results suggested that patients with a high tumor marker ratio could be switched to alternative therapeutic regimens despite the SD response to HAIC.

Published
2016

3. Levocarnitine Use Is Associated With Improvement in Sarcopenia in Patients With Liver Cirrhosis

Author

Hiramatsu, Akira, primary, Aikata, Hiroshi, additional, Uchikawa, Shinsuke, additional, Ohya, Kazuki, additional, Kodama, Kenichiro, additional, Nishida, Yuno, additional, Daijo, Kana, additional, Osawa, Mitsutaka, additional, Teraoka, Yuji, additional, Honda, Fumi, additional, Inagaki, Yuki, additional, Morio, Kei, additional, Morio, Reona, additional, Fujino, Hatsue, additional, Nakahara, Takashi, additional, Murakami, Eisuke, additional, Yamauchi, Masami, additional, Kawaoka, Tomokazu, additional, Miki, Daiki, additional, Tsuge, Masataka, additional, Imamura, Michio, additional, Tanaka, Junko, additional, and Chayama, Kazuaki, additional

Published
2019
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4. Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring

Author

Honda, Fumi, primary, Hiramatsu, Akira, additional, Hyogo, Hideyuki, additional, Aikata, Hiroshi, additional, Daijo, Kana, additional, Teraoka, Yuji, additional, Inagaki, Yuki, additional, Morio, Kei, additional, Kobayashi, Tomoki, additional, Nakahara, Takashi, additional, Nagaoki, Yuko, additional, Kawaoka, Tomokazu, additional, Yoneda, Masayasu, additional, Tsuge, Masataka, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Ochi, Hidenori, additional, and Chayama, Kazuaki, additional

Published
2018
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5. The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy

Author

Nagaoki, Yuko, primary, Imamura, Michio, additional, Aikata, Hiroshi, additional, Daijo, Kana, additional, Teraoka, Yuji, additional, Honda, Fumi, additional, Nakamura, Yuki, additional, Hatooka, Masahiro, additional, Morio, Reona, additional, Morio, Kei, additional, Kan, Hiromi, additional, Fujino, Hatsue, additional, Kobayashi, Tomoki, additional, Masaki, Keiichi, additional, Ono, Atsushi, additional, Nakahara, Takashi, additional, Kawaoka, Tomokazu, additional, Tsuge, Masataka, additional, Hiramatsu, Akira, additional, Kawakami, Yoshiiku, additional, Hayes, C. Nelson, additional, Miki, Daiki, additional, Ochi, Hidenori, additional, and Chayama, Kazuaki, additional

Published
2017
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