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1. SGLT2-Inhibition in Patients With Alport Syndrome

Author

Boeckhaus, Jan, Gale, Daniel P., Simon, James, Ding, Jie, Zhang, Yanqin, Bergmann, Carsten, Turner, A. Neil, Hall, Matthew, Sayer, John A., Srivastava, Shalabh, Kang, Hee Gyung, Cerkauskaite-Kerpauskiene, Agne, Gillion, Valentine, Claes, Kathleen J., Krueger, Bastian, de Fallois, Jonathan, Walden, Ulrike, Choi, Mira, Schueler, Markus, Mueller, Roman-Ulrich, Todorova, Polina, Hohenstein, Bernd, Zeisberg, Michael, Friede, Tim, Knebelmann, Bertrand, Halbritter, Jan, and Gross, Oliver

Published
2024
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2. Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling

Author

Rodionov, Roman N., Jarzebska, Natalia, Burdin, Dmitrii, Todorov, Vladimir, Martens-Lobenhoffer, Jens, Hofmann, Anja, Kolouschek, Anne, Cordasic, Nada, Jacobi, Johannes, Rubets, Elena, Morawietz, Henning, O’Sullivan, John F., Markov, Alexander G., Bornstein, Stefan R., Hilgers, Karl, Maas, Renke, Pfluecke, Christian, Chen, YingJie, Bode-Böger, Stefanie M., Hugo, Christian P. M., Hohenstein, Bernd, and Weiss, Norbert

Published
2022
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3. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy

Author

Floege, Jürgen, Eitner, Frank, Rauen, Thomas, Moeller, Marcus J., Weihprecht, Horst, Budde, Klemens, Peters, Harm, Elitok, Saban, Bieringer, Markus, Schindler, Ralf, Frei, Ulrich, Canaan–Kühl, Sima, Erley, Christiane, Schlieps, Karsten, Kuhlmann, Uwe, Zandvoort, Frans, Hohenstein, Bernd, Hugo, Christian, Palm, Catrin, Hilgers, Karl, Witzke, Oliver, Gross, Oliver, Panzer, Ulf, Haller, Hermann, Bertram, Anna, Sommerer, Claudia, Zeier, Martin, Wolf, Gunter, Busch, Martin, Rath, Thomas, Ziefle, Stephan, Benzing, Thomas, Grundmann, Franziska, Mertens, Peter R., Westphalen, Stefan, Benck, Urs, Göttmann, Uwe, Vielhauer, Volker, Fischereder, Michael, Sarkar, Oliver, Stefanidou, Marianna, Mann, Johannes F.E., Otte, Britta, Pavenstädt, Hermann, Banas, Bernhard, Boeger, Alexander, Heyne, Nils, Artunc, Ferruh, Reichel, Helmut, Mettang, Thomas, Wanner, Christoph, Metzger, Thomas, Wied, Stephanie, Fitzner, Christina, and Hilgers, Ralf-Dieter

Published
2020
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4. A microphysiological system to investigate the pressure dependent filtration at an artificial glomerular kidney barrier

Author

Schmieder Florian, Behrens Stefan, Reustle Nina, Franke Nathalie, Sonntag Frank, Sradnick Jan, and Hohenstein Bernd

Subjects
glomerular filtration barrier, chronic kidney disease, glomerulus on chip, hypertonia on chip, Medicine
Abstract

Chronic kidney disease (CKD) is a global health problem that affects around 11 to 13% of the world’s population and more than 18% of European citizens. Characteristic syndromes of CKD during all stages of the disease are proteinuria and ongoing glomerular dysfunction caused by cellular damages at the glomerular filtration barrier. While some rare cases of the disease are correlated to genetic depositions the majority of cases are caused by diabetes, glomerulosclerosis, high blood pressure and glomerulonephritis. Thus, recapitulating the interplay of high blood pressure and changes at the glomerular filtration barrier in vitro seems an adequate way to mimic CKD. Here we present a microphysiological system of the glomerular filter that is capable to simulate high blood pressure at the glomerular filtration barrier in vitro. It consists of a closed loop microfluidic circuit with an integrated pneumatically driven heart like micro pump that constantly circulates the cell culture media at the blood site of the glomerular barrier. The ThinCert™ insert could be reversibly integrated into a holder system that ensures the correct position of the insert within the microfluidic circuit. By using different modulations of the integrated pneumatic micro pump different physiological and pathophysiological conditions e.g. hypertonic stress, like in CKD, could be applied. The influence of hypertonic conditions on the filtration above the barrier was studied by changes of TEER values and measurement of the flux of fluorescent labelled albumin through the cellular barrier.

Published
2019
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5. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality)

Author

Pilgram, Lisa, Eberwein, Lukas, Jensen, Bjoern-Erik O., Jakob, Carolin E. M., Koehler, Felix C., Hower, Martin, Kielstein, Jan T., Stecher, Melanie, Hohenstein, Bernd, Prasser, Fabian, Westhoff, Timm, de Miranda, Susana M. Nunes, Vehreschild, Maria J. G. T., Lanznaster, Julia, Dolff, Sebastian, Pilgram, Lisa, Eberwein, Lukas, Jensen, Bjoern-Erik O., Jakob, Carolin E. M., Koehler, Felix C., Hower, Martin, Kielstein, Jan T., Stecher, Melanie, Hohenstein, Bernd, Prasser, Fabian, Westhoff, Timm, de Miranda, Susana M. Nunes, Vehreschild, Maria J. G. T., Lanznaster, Julia, and Dolff, Sebastian

Abstract

Purpose Patients suffering from chronic kidney disease (CKD) are in general at high risk for severe coronavirus disease (COVID-19) but dialysis-dependency (CKD5D) is poorly understood. We aimed to describe CKD5D patients in the different intervals of the pandemic and to evaluate pre-existing dialysis dependency as a potential risk factor for mortality. Methods In this multicentre cohort study, data from German study sites of the Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) were used. We multiply imputed missing data, performed subsequent analyses in each of the imputed data sets and pooled the results. Cases (CKD5D) and controls (CKD not requiring dialysis) were matched 1:1 by propensity-scoring. Effects on fatal outcome were calculated by multivariable logistic regression. Results The cohort consisted of 207 patients suffering from CKD5D and 964 potential controls. Multivariable regression of the whole cohort identified age (> 85 years adjusted odds ratio (aOR) 7.34, 95% CI 2.45-21.99), chronic heart failure (aOR 1.67, 95% CI 1.25-2.23), coronary artery disease (aOR 1.41, 95% CI 1.05-1.89) and active oncological disease (aOR 1.73, 95% CI 1.07-2.80) as risk factors for fatal outcome. Dialysis-dependency was not associated with a fatal outcome-neither in this analysis (aOR 1.08, 95% CI 0.75-1.54) nor in the conditional multivariable regression after matching (aOR 1.34, 95% CI 0.70-2.59). Conclusions In the present multicentre German cohort, dialysis dependency is not linked to fatal outcome in SARS-CoV-2-infected CKD patients. However, the mortality rate of 26% demonstrates that CKD patients are an extreme vulnerable population, irrespective of pre-existing dialysis-dependency.

Published
2023

6. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality)

Author

Pilgram, Lisa, Eberwein, Lukas, Jensen, Bjoern-Erik O., Jakob, Carolin E. M., Koehler, Felix C., Hower, Martin, Kielstein, Jan T., Stecher, Melanie, Hohenstein, Bernd, Prasser, Fabian, Westhoff, Timm, de Miranda, Susana M. Nunes, Vehreschild, Maria J. G. T., Lanznaster, Julia, Dolff, Sebastian, Spinner, Christoph, Ruethrich, Maria Madeleine, Tometten, Lukas, Borgmann, Stefan, Jung, Norma, Hertenstein, Bernd, Degenhardt, Christian, Voigt, Ingo, Hanses, Frank, Wille, Kai, vom Dahl, Jürgen, Rothfuss, Katja, Hellwig, Kerstin, Rupp, Jan, Isberner, Nora, Nattermann, Jacob, Strauss, Richard, Göpel, Siri, Vehreschild, Jörg Janne, Schulze, Nick, Fuhrmann, Sandra, Schons, Max, Claßen, Annika, and Franke, Bernd

Subjects
Microbiology (medical), Infectious Diseases, Medizin, General Medicine
Abstract

Purpose Patients suffering from chronic kidney disease (CKD) are in general at high risk for severe coronavirus disease (COVID-19) but dialysis-dependency (CKD5D) is poorly understood. We aimed to describe CKD5D patients in the different intervals of the pandemic and to evaluate pre-existing dialysis dependency as a potential risk factor for mortality. Methods In this multicentre cohort study, data from German study sites of the Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) were used. We multiply imputed missing data, performed subsequent analyses in each of the imputed data sets and pooled the results. Cases (CKD5D) and controls (CKD not requiring dialysis) were matched 1:1 by propensity-scoring. Effects on fatal outcome were calculated by multivariable logistic regression. Results The cohort consisted of 207 patients suffering from CKD5D and 964 potential controls. Multivariable regression of the whole cohort identified age (> 85 years adjusted odds ratio (aOR) 7.34, 95% CI 2.45–21.99), chronic heart failure (aOR 1.67, 95% CI 1.25–2.23), coronary artery disease (aOR 1.41, 95% CI 1.05–1.89) and active oncological disease (aOR 1.73, 95% CI 1.07–2.80) as risk factors for fatal outcome. Dialysis-dependency was not associated with a fatal outcome—neither in this analysis (aOR 1.08, 95% CI 0.75–1.54) nor in the conditional multivariable regression after matching (aOR 1.34, 95% CI 0.70–2.59). Conclusions In the present multicentre German cohort, dialysis dependency is not linked to fatal outcome in SARS-CoV-2-infected CKD patients. However, the mortality rate of 26% demonstrates that CKD patients are an extreme vulnerable population, irrespective of pre-existing dialysis-dependency.

Published
2022
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7. 3D printing – a key technology for tailored biomedical cell culture lab ware

Author

Schmieder Florian, Ströbel Joachim, Rösler Mechthild, Grünzner Stefan, Hohenstein Bernd, Klotzbach Udo, and Sonntag Frank

Subjects
additive manufacturing, 3D cell culture, 3D printing, microfluidics, tissue engineering, Medicine
Abstract

Today’s 3D printing technologies offer great possibilities for biomedical researchers to create their own specific laboratory equipment. With respect to the generation of ex vivo vascular perfusion systems this will enable new types of products that will embed complex 3D structures possibly coupled with cell loaded scaffolds closely reflecting the in-vivo environment. Moreover this could lead to microfluidic devices that should be available in small numbers of pieces at moderate prices. Here, we will present first results of such 3D printed cell culture systems made from plastics and show their use for scaffold based applications.

Published
2016
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10. Convalescent plasma treatment for SARS-CoV-2 infected high-risk patients: a matched pair analysis to the LEOSS cohort

Author

Freise, Noemi F., Gliga, Smaranda, Fischer, Johannes, Lübke, Nadine, Lutterbeck, Matthias, Schöler, Miriam, Bölke, Edwin, Orth, Hans Martin, Feldt, Torsten, Roemmele, Christoph, Wilke, Dominik, Schneider, Jochen, Wille, Kai, Hohmann, Christian, Strauss, Richard, Hower, Martin, Ruf, Andreas, Schubert, Joerg, Isberner, Nora, Stecher, Melanie, Pilgram, Lisa, Vehreschild, Jörg J., de With, Katja, Spinner, Christoph, Lanznaster, Julia, Beutel, Gernot, Jung, Norma, Göpel, Siri, Westhoff, Timm, Hohenstein, Bernd, Rothfuss, Katja, Rieg, Siegbert, Ruethrich, Maria Madeleine, Rupp, Jan, Hanses, Frank, Luedde, Tom, and Jensen, Björn

Subjects
Multidisciplinary, SARS-CoV-2, Renal Dialysis, Matched-Pair Analysis, Immunization, Passive, Humans, COVID-19, ddc:610, COVID-19 Serotherapy, Retrospective Studies
Abstract

BackgroundEstablishing the optimal treatment for COVID-19 patients remains challenging. Specifically, immunocompromised and pre-diseased patients are at high risk for severe disease course and face limited therapeutic options. Convalescent plasma has been considered as therapeutic approach, but reliable data are lacking, especially for high-risk patients.MethodsWe performed a retrospective analysis of 55 hospitalized COVID-19 patients with high risk for disease progression, primarily due to immunosuppression from cancer, solid organ transplantation, autoimmune disease, dialysis. A matched-pairs analysis (1:4) was performed with 220 patients from the Lean European Open Survey on SARS-CoV-2-infected Patients (LEOSS) who were treated or not treated with convalescent plasma. ResultsBoth cohorts, had high mortality (UKD 41.8%, LEOSS 34.1%). A matched-pairs analysis showed no significant effect on mortality. CP administration before the formation of pulmonary infiltrates showed the lowest mortality in both cohorts (10%), whereas mortality in the complicated phase was 27.8%. CP administration during the critical phase revealed the highest mortality; UKD 60.9%, LEOSS 48.3%. ConclusionIn our cohort of SARS-CoV-2 infected patients with severe comorbidities CP did not significantly reduce mortality in a retrospective matched pairs analysis. However, our data supports the concept that a reduction in mortality is achievable when CP is administered early.

Published
2022

12. Clinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease

Author

Wille, Kai, Koehler, Felix C., Stecher, Melanie, Rieg, Siegbert, Kielstein, Jan T., Jakob, Carolin E. M., Rüthrich, Maria, Burst, Volker, Borgmann, Stefan, Müller, Roman-Ulrich, Lanznaster, Julia, Dolff, Sebastian, Tometten, Lukas, Wettstein, Matthias, Isberner, Nora, Spinner, Christoph, Raichle, Claudia, Neufang, Mark, Hanses, Frank, Hohenstein, Bernd, Stieglitz, Sven, Jung, Norma, Bals, Robert, Schubert, Joerg, Worm, Maximilian, Degenhardt, Christian, Brandenburger, Timo, Fuerst, Julia, Vehreschild, Maria, Keller, Ulrich, Hower, Martin, von Bergwelt-Baildon, Michael, Rueddel, Jessica, de With, Katja, Gruener, Beate, Eberwein, Lukas, Schultheis, Beate, Heigener, David, Guggemos, Wolfgang, Peetz, Helga, Walter, Lorenz, Prattes, Juergen, Rothfuss, Katja, Hellwig, Kerstin, Nattermann, Jacob, Merle, Uta, Droehmann, Daniel, Rauschning, Dominic, Mueller-Joerger, Gabriele, Weidemann, Alexander, Piepel, Christiane, Ritter, Annika, Beutel, Gernot, Trauth, Janina, Friedrichs, Anette, Bethge, Wolfgang, Vehreschild, Joerg Janne, Pilgram, Lisa, Schons, Maximilian, Classen, Annika, Fuhrmann, Sandra, Franke, Bernd, Schulze, Nick, Prasser, Fabian, and Lablans, Martin

Subjects
Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, Anemia, medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medizin, Disease, Comorbidity, 030204 cardiovascular system & hematology, Logistic regression, LEOSS, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, Chronic kidney disease, Medicine, Humans, 030212 general & internal medicine, Renal replacement therapy, Renal Insufficiency, Chronic, Aged, 80 and over, Original Paper, business.industry, SARS-CoV-2, COVID-19, General Medicine, Odds ratio, Middle Aged, medicine.disease, Infectious Diseases, Logistic Models, Cohort, business, Predictive factor, Kidney disease
Abstract

Purpose The ongoing pandemic caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2) has stressed health systems worldwide. Patients with chronic kidney disease (CKD) seem to be more prone to a severe course of coronavirus disease (COVID-19) due to comorbidities and an altered immune system. The study’s aim was to identify factors predicting mortality among SARS-CoV-2-infected patients with CKD. Methods We analyzed 2817 SARS-CoV-2-infected patients enrolled in the Lean European Open Survey on SARS-CoV-2-infected patients and identified 426 patients with pre-existing CKD. Group comparisons were performed via Chi-squared test. Using univariate and multivariable logistic regression, predictive factors for mortality were identified. Results Comparative analyses to patients without CKD revealed a higher mortality (140/426, 32.9% versus 354/2391, 14.8%). Higher age could be confirmed as a demographic predictor for mortality in CKD patients (> 85 years compared to 15–65 years, adjusted odds ratio (aOR) 6.49, 95% CI 1.27–33.20, p = 0.025). We further identified markedly elevated lactate dehydrogenase (> 2 × upper limit of normal, aOR 23.21, 95% CI 3.66–147.11, p p = 0.002), anemia (Hb p = 0.024), and C-reactive protein (≥ 30 mg/l, aOR 3.44, 95% CI 1.13–10.45, p = 0.029) as predictors, while renal replacement therapy was not related to mortality (aOR 1.15, 95% CI 0.68–1.93, p = 0.611). Conclusion The identified predictors include routinely measured and universally available parameters. Their assessment might facilitate risk stratification in this highly vulnerable cohort as early as at initial medical evaluation for SARS-CoV-2.

Published
2021

13. Solid organ transplantation is not a risk factor for COVID-19 disease outcome

Author

Hugo, Christian, Stecher, Melanie, Dolff, Sebastian, Nattermann, Jacob, Vehreschild, Jorg, Hippchen, Theresa, Westhoff, Timm, Bertolo, Martina, Hohenstein, Bernd, Hanses, Frank, Strassburg, Christian, Hugo, Christian, Stecher, Melanie, Dolff, Sebastian, Nattermann, Jacob, Vehreschild, Jorg, Hippchen, Theresa, Westhoff, Timm, Bertolo, Martina, Hohenstein, Bernd, Hanses, Frank, and Strassburg, Christian

Published
2021

15. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Author

Higgins, Debra F., Kimura, Kuniko, Bernhardt, Wanja M., Shrimanker, Nikita, Akai, Yasuhiro, Hohenstein, Bernd, Saito, Yoshihiko, Johnson, Randall S., Kretzler, Matthias, Cohen, Clemens D., Eckardt, Kai-Uwe, Iwano, Masayuki, and Haase, Volker H.

Subjects
Fibrosis -- Risk factors, Fibrosis -- Genetic aspects, Fibrosis -- Research, Hypoxia (Aquatic ecology) -- Health aspects, Hypoxia (Aquatic ecology) -- Research
Abstract

Hypoxia has been proposed as an important microenvironmental factor in the development of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the role of hypoxia-inducible factor-1 (HIF-1), a key mediator of cellular adaptation to hypoxia, in the development of fibrosis in mice, we inactivated Hif-1[alpha] in primary renal epithelial cells and in proximal tubules of kidneys subjected to unilateral ureteral obstruction (UUO) using Cre-loxP-mediated gene targeting. We found that Hif-1[alpha] enhanced epithelial-tomesenchymal transition (EMT) in vitro and induced epithelial cell migration through upregulation of lysyl oxidase genes. Genetic ablation of epithelial Hif-1[alpha] inhibited the development of tubulointerstitial fibrosis in UUO kidneys, which was associated with decreased interstitial collagen deposition, decreased inflammatory cell infiltration, and a reduction in the number of fibroblast-specific protein-1-expressing (FSP-1-expressing) interstitial cells. Furthermore, we demonstrate that increased renal HIF-1[alpha] expression is associated with tubulointerstitial injury in patients with chronic kidney disease. Thus, we provide clinical and genetic evidence that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT., Introduction Peritubular capillary loss and reduced blood flow limit oxygen supply to the renal interstitium, leading to chronic interstitial and tubular cell hypoxia, which can initiate and sustain interstitial scarring [...]

Published
2007

17. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy

Author

Rauen, Thomas, primary, Wied, Stephanie, additional, Fitzner, Christina, additional, Eitner, Frank, additional, Sommerer, Claudia, additional, Zeier, Martin, additional, Otte, Britta, additional, Panzer, Ulf, additional, Budde, Klemens, additional, Benck, Urs, additional, Mertens, Peter R., additional, Kuhlmann, Uwe, additional, Witzke, Oliver, additional, Gross, Oliver, additional, Vielhauer, Volker, additional, Mann, Johannes F.E., additional, Hilgers, Ralf-Dieter, additional, Floege, Jürgen, additional, Rauen, Thomas, additional, Moeller, Marcus J., additional, Weihprecht, Horst, additional, Peters, Harm, additional, Elitok, Saban, additional, Bieringer, Markus, additional, Schindler, Ralf, additional, Frei, Ulrich, additional, Canaan–Kühl, Sima, additional, Erley, Christiane, additional, Schlieps, Karsten, additional, Zandvoort, Frans, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Palm, Catrin, additional, Hilgers, Karl, additional, Haller, Hermann, additional, Bertram, Anna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Rath, Thomas, additional, Ziefle, Stephan, additional, Benzing, Thomas, additional, Grundmann, Franziska, additional, Westphalen, Stefan, additional, Göttmann, Uwe, additional, Fischereder, Michael, additional, Sarkar, Oliver, additional, Stefanidou, Marianna, additional, Pavenstädt, Hermann, additional, Banas, Bernhard, additional, Boeger, Alexander, additional, Heyne, Nils, additional, Artunc, Ferruh, additional, Reichel, Helmut, additional, Mettang, Thomas, additional, Wanner, Christoph, additional, and Metzger, Thomas, additional

Published
2020
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27. Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage

Author

Lachmann, Peter, primary, Hickmann, Linda, additional, Steglich, Anne, additional, Al-Mekhlafi, Moath, additional, Gerlach, Michael, additional, Jetschin, Niels, additional, Jahn, Steffen, additional, Hamann, Brigitte, additional, Wnuk, Monika, additional, Madsen, Kirsten, additional, Djonov, Valentin, additional, Chen, Min, additional, Weinstein, Lee S., additional, Hohenstein, Bernd, additional, Hugo, Christian P.M., additional, and Todorov, Vladimir T., additional

Published
2017
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28. Abstract 185: Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function

Author

Rodionov, Roman N, primary, Burdin, Dmitri, additional, Brilloff, Silke, additional, Todorov, Vladimir, additional, Jarzebska, Natalia, additional, Martens-Lobenhoffer, Jens, additional, Hofmann, Anja, additional, Morawietz, Henning, additional, Hilgers, Karl, additional, Cordasic, Nada, additional, Jacobi, Johannes, additional, Maas, Renke, additional, Chen, YingJie, additional, Bode-Böger, Stefanie M, additional, Hugo, Christian P, additional, Hohenstein, Bernd, additional, and Weiss, Norbert, additional

Published
2017
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30. Mortalität und Morbidität von chronischen Dialysepatienten bei Besiedlung mit Methicillin-sensiblem Staphylococcus aureus sowie Methicillin-resistentem Staphylococcus aureus

Author

Beige, Joachim, Rodloff, Arne, Hohenstein, Bernd, Universität Leipzig, Weiß, Susanne, Beige, Joachim, Rodloff, Arne, Hohenstein, Bernd, Universität Leipzig, and Weiß, Susanne

Abstract

Systemische Infektionen mit S. aureus (MSSA und MRSA) und Infektionen des Gefäßzugangs bei HD-Patienten sind eine der wichtigsten Ursachen für Morbidität und Mortalität in dieser speziellen Population. Infektionsrisikos stellen die zunehmende Verwendung von Fremdkörpern, wie Katheter und Graft als Gefäßzugänge, sowie die intensivmedizinische Behandlung bei älteren und multimorbiden Patienten dar. Unter den bakteriell bedingten Infektionen bleiben Staphylokokken der am häufigsten nachgewiesene Stamm. Mit dem zunehmenden Gebrauch von Vancomycin zur Behandlung von MSSA-Infektionen hat das Vorkommen von MRSA zugenommen. Dies macht die Entwicklung von alternativen Antibiotikaregimen nötig, die eine Selektion von MRSA-Spezies verhindern. Unter dieser Überlegung wurde auf die Behandlung mit Vancomycin bei Zugangs-bezogenen Infektionen verzichtet. Es wurde im Jahr 2000 durch ein Standardregime bestehend aus Flucloxacillin und Rifampicin ersetzt. Mithilfe eines Screeningprogramms wurde nach MSSA- (n=88) und MRSA- (n=1) Kolonisationen gesucht. Dies gelang mit Hilfe von Querschnitts-Screenings und Indikations-Screeninguntersuchungen bei Aufnahme über den Zeitraum von 2000 bis 2010. Eine Besiedlung mit MRSA wurde bei nur einem Patienten während des 10-Jahres-Screenings registriert. Die gefundenen MSSA-Kolonisationen bei HD-Patienten beeinflussten die Morbidität und Mortalität nicht. Die Anzahl an HD-Patienten mit MSSA-Kolonisation nahm während des Beobachtungszeitraums von zehn Jahren ab Behandlungen mit dem Vancomycin-freien Regime waren generell erfolgreich und resultierten in einem Rückgang der klinischen und laborativen Infektionsmarker und/oder negativen Blutkulturen. Es konnte gezeigt werden, dass mit dem Gebrauch von vancomycinfreien Antibiotikaregimen ein erfolgreiches Management von Staphylokokkus-assoziierten Zugangsinfektionen bei HD-Patienten möglich ist.

Published
2016

31. Mortalität und Morbidität von chronischen Dialysepatienten bei Besiedlung mit Methicillin-sensiblem Staphylococcus aureus sowie Methicillin-resistentem Staphylococcus aureus

Author

Rodloff, Arne, Hohenstein, Bernd, Universität Leipzig, Weiß, Susanne, Rodloff, Arne, Hohenstein, Bernd, Universität Leipzig, and Weiß, Susanne

Abstract

Systemische Infektionen mit S. aureus (MSSA und MRSA) und Infektionen des Gefäßzugangs bei HD-Patienten sind eine der wichtigsten Ursachen für Morbidität und Mortalität in dieser speziellen Population. Infektionsrisikos stellen die zunehmende Verwendung von Fremdkörpern, wie Katheter und Graft als Gefäßzugänge, sowie die intensivmedizinische Behandlung bei älteren und multimorbiden Patienten dar. Unter den bakteriell bedingten Infektionen bleiben Staphylokokken der am häufigsten nachgewiesene Stamm. Mit dem zunehmenden Gebrauch von Vancomycin zur Behandlung von MSSA-Infektionen hat das Vorkommen von MRSA zugenommen. Dies macht die Entwicklung von alternativen Antibiotikaregimen nötig, die eine Selektion von MRSA-Spezies verhindern. Unter dieser Überlegung wurde auf die Behandlung mit Vancomycin bei Zugangs-bezogenen Infektionen verzichtet. Es wurde im Jahr 2000 durch ein Standardregime bestehend aus Flucloxacillin und Rifampicin ersetzt. Mithilfe eines Screeningprogramms wurde nach MSSA- (n=88) und MRSA- (n=1) Kolonisationen gesucht. Dies gelang mit Hilfe von Querschnitts-Screenings und Indikations-Screeninguntersuchungen bei Aufnahme über den Zeitraum von 2000 bis 2010. Eine Besiedlung mit MRSA wurde bei nur einem Patienten während des 10-Jahres-Screenings registriert. Die gefundenen MSSA-Kolonisationen bei HD-Patienten beeinflussten die Morbidität und Mortalität nicht. Die Anzahl an HD-Patienten mit MSSA-Kolonisation nahm während des Beobachtungszeitraums von zehn Jahren ab Behandlungen mit dem Vancomycin-freien Regime waren generell erfolgreich und resultierten in einem Rückgang der klinischen und laborativen Infektionsmarker und/oder negativen Blutkulturen. Es konnte gezeigt werden, dass mit dem Gebrauch von vancomycinfreien Antibiotikaregimen ein erfolgreiches Management von Staphylokokkus-assoziierten Zugangsinfektionen bei HD-Patienten möglich ist.

Published
2016

32. Alirocumab in patients with heterozygous familial hypercholesterolaemia undergoing lipoprotein apheresis: the ODYSSEY ESCAPE trial

Author

Moriarty, Patrick M., primary, Parhofer, Klaus G., additional, Babirak, Stephan P., additional, Cornier, Marc-Andre, additional, Duell, P. Barton, additional, Hohenstein, Bernd, additional, Leebmann, Josef, additional, Ramlow, Wolfgang, additional, Schettler, Volker, additional, Simha, Vinaya, additional, Steinhagen-Thiessen, Elisabeth, additional, Thompson, Paul D., additional, Vogt, Anja, additional, von Stritzky, Berndt, additional, Du, Yunling, additional, and Manvelian, Garen, additional

Published
2016
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33. Abstract 453: Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function

Author

Jarzebska, Natalia, primary, Rodionov, Roman N, additional, Burdin, Dmitri, additional, Brilloff, Silke, additional, Todorov, Vladimir T, additional, Martens-Lobenhoffer, Jens, additional, Hofmann, Anja, additional, Morawietz, Henning, additional, Demyanov, Anton, additional, Hilgers, Karl, additional, Cordasic, Nada, additional, Jacobi, Johannes, additional, Maas, Renke, additional, Chen, YingJie, additional, Bode-Böger, Stefanie M, additional, Hugo, Christian P, additional, Hohenstein, Bernd, additional, and Weiss, Norbert, additional

Published
2016
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35. Abstract 17603: Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function

Author

Rodionov, Roman N, primary, Burdin, Dmitrii, additional, Brilloff, Silke, additional, Todorov, Vladimir, additional, Jarzebska, Natalia, additional, Martens-Lobenhoffer, Jens, additional, Demyanov, Anton, additional, Hilgers, Karl, additional, Cordasic, Nada, additional, Jacobi, Johannes, additional, Maas, Renke, additional, Hofmann, Anja, additional, Morawietz, Henning, additional, Bode-Böger, Stefanie M, additional, Hugo, Christian P, additional, Hohenstein, Bernd, additional, and Weiss, Norbert, additional

Published
2015
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37. Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

Author

Kumar, Santhosh V.R., primary, Kulkarni, Onkar P., additional, Mulay, Shrikant R., additional, Darisipudi, Murthy N., additional, Romoli, Simone, additional, Thomasova, Dana, additional, Scherbaum, Christina R., additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Müller, Susanna, additional, Liapis, Helen, additional, and Anders, Hans-Joachim, additional

Published
2015
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41. Abstract 373: Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 Lowers Tissue Levels of Asymmetric Dimethylarginine and Improves Endothelial Function in Mouse Aortas

Author

Rodionov, Roman N, primary, Burdin, Dmitrii V, additional, Todorov, Vladimir, additional, Brilloff, Silke, additional, Jarzebska, Natalia, additional, Martens-Lobenhoffer, Jens, additional, Hofmann, Anja, additional, Morawietz, Henning, additional, Demyanov, Anton V, additional, Maas, Renke, additional, Bode-Böger, Stefanie M, additional, Hugo, Christian P, additional, Hohenstein, Bernd, additional, and Weiss, Norbert, additional

Published
2015
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42. Renin Lineage Cells Repopulate the Glomerular Mesangium after Injury

Author

Starke, Charlotte, primary, Betz, Hannah, additional, Hickmann, Linda, additional, Lachmann, Peter, additional, Neubauer, Björn, additional, Kopp, Jeffrey B., additional, Sequeira-Lopez, Maria Luisa S., additional, Gomez, R. Ariel, additional, Hohenstein, Bernd, additional, Todorov, Vladimir T., additional, and Hugo, Christian P.M., additional

Published
2015
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45. Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy

Author

Rodionov, Roman N., primary, Martens-Lobenhoffer, Jens, additional, Brilloff, Silke, additional, Hohenstein, Bernd, additional, Jarzebska, Natalia, additional, Jabs, Normund, additional, Kittel, Anja, additional, Maas, Renke, additional, Weiss, Norbert, additional, and Bode-Böger, Stefanie M., additional

Published
2014
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48. Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

Author

Allam, Ramanjaneyulu, primary, Scherbaum, Christina Rebecca, additional, Darisipudi, Murthy Narayana, additional, Mulay, Shrikant R., additional, Hägele, Holger, additional, Lichtnekert, Julia, additional, Hagemann, Jan Henrik, additional, Rupanagudi, Khader Valli, additional, Ryu, Mi, additional, Schwarzenberger, Claudia, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Uhl, Bernd, additional, Reichel, Christoph A., additional, Krombach, Fritz, additional, Monestier, Marc, additional, Liapis, Helen, additional, Moreth, Kristin, additional, Schaefer, Liliana, additional, and Anders, Hans-Joachim, additional

Published
2012
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49. Chicken Ovalbumin Upstream Promoter Transcription Factor II Regulates Renin Gene Expression

Author

Mayer, Sandra, primary, Roeser, Marc, additional, Lachmann, Peter, additional, Ishii, Sumiyashi, additional, Suh, Jae Mi, additional, Harlander, Sabine, additional, Desch, Michael, additional, Brunssen, Coy, additional, Morawietz, Henning, additional, Tsai, Sophia Y., additional, Tsai, Ming-Jer, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, and Todorov, Vladimir T., additional

Published
2012
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50. PDGF-C Mediates Glomerular Capillary Repair

Author

Boor, Peter, primary, van Roeyen, Claudia R.C., additional, Kunter, Uta, additional, Villa, Luigi, additional, Bücher, Eva, additional, Hohenstein, Bernd, additional, Hugo, Christian P.M., additional, Eriksson, Ulf, additional, Satchell, Simon C., additional, Mathieson, Peter W., additional, Eitner, Frank, additional, Floege, Jürgen, additional, and Ostendorf, Tammo, additional

Published
2010
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