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Abstract Background The available information on granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease (IBD) under special situations remains unclear. We conducted a retrospective, multicentre cohort study to evaluate the safety and effectiveness of GMA in patients with IBD under special situations. Methods This study included patients with ulcerative colitis (UC) or Crohn’s disease who had at least one special situation feature and who had received GMA between November 2013 and March 2017. The incidence of adverse events (AEs) was compared in relation to the special situation, and patient background factors related to an AE were identified. For patients with UC, clinical remission was defined as a partial Mayo score of ≤2. Results A total of 437 patients were included in this study. The incidence of AEs among the elderly patients (11.2%) was similar in all patients (11.4%), whereas the incidences of AEs in patients on multiple immunosuppressant medications (15.2%), patients with anaemia (18.1%) and paediatric/adolescent patients (18.9%) were higher than that in all patients (11.4%). In multivariate analysis, anaemia and concomitant immunosuppressant medications were independently associated with the incidence of AEs. Clinical remission was achieved in 46.4% of the patients with UC. Conclusions The incidence of AEs in the elderly patients was not higher than that in all patients, whereas the incidence of AE was higher in patients with anaemia and those on multiple immunosuppressant medications than that in all patients. GMA is a safe treatment option in elderly patients with IBD.

This study evaluates the heat dissipation and Nusselt number for an S-shaped double-bend pipe, for which an experimental evaluation is lacking. In terms of the velocity field, the mean velocity and turbulent kinetic energy were measured through particle image velocimetry. Heat transfer characteristics were evaluated in validated conjugate heat transfer simulations, and a k-ω SST turbulence model was used for flow simulation inside the pipe. Heat transfer enhancement was observed at the first bend, as observed in previous studies on single-bend and U-shaped bends, whereas no heat transfer enhancement was observed at the second bend. This result was due to higher turbulent heat flux at the first bend because of higher eddy diffusion on the outside of the bend, whereas eddy diffusion was lower on the outside of the second bend owing to the history of the first bend. The heat transfer characteristics of the S-shaped double-bend pipe elucidated in this study provide valuable insight for devising strategies to reduce heat loss in automotive exhaust pipes with multiple bends. Furthermore, the conjugate heat transfer simulation model used in this study provides a benchmark for heat transfer calculations for multi-bend pipes.

The turbulent pulsating flow and heat transfer in straight and 90° curved square pipes are investigated in this study. Both experimental temperature field measurements at the cross-sections of the pipes and conjugate heat transfer (CHT) simulation were performed. The steady turbulent flow was investigated and compared to the pulsating flow under the same time-averaged Reynolds number. The time-averaged Reynolds number of the pulsating flow, as well as the steady flow, was approximately 60,000. The Womersley number of the pulsating flow was 43.1, corresponding to a 30 Hz pulsating frequency. Meanwhile, the Dean number in the curved pipe was approximately 31,000. The results showed that the local heat flux of the pulsating flow was greater than that of the steady flow when the location was closer to the upstream pulsation generator. However, the total heat flux of the pulsating flow was less than that of the steady flow. Moreover, the instantaneous velocity and temperature fields of the simulation were used to demonstrate the heat transfer mechanism of the pulsating flow. The behaviors, such as the obvious separation between the air and pipe wall, the low-temperature core impingement, and the reverse flow, suppress the heat transfer.

Much attention has recently been given to high-efficiency cooling of pistons in internal combustion engines by cooling channels because of improved thermal efficiency. Cooling a piston efficiently requires a grasp of the gas-liquid multiphase flow state. However, because the magnitude and direction of the inertial force applied to the piston change depending on the crank angle, the flow field in the cooling channel that forms a complex gas-liquid multiphase flow remains a problem. Therefore, we developed a rig test apparatus simulating the reciprocating motion of a piston and visualized internal flows in a clear acrylic channel using a high-speed camera. This paper examines the effects of the Reynolds number of the oil jet and oscillation frequency of the reciprocating motion on flow characteristics in a right circular cylindrical channel. The Reynolds number and oscillation frequency were tested in the ranges 1000 to 2500 and 0 to 8.33 Hz, respectively. We found that the oil flow pattern in the channel forms the complex air-oil multiphase flow via air entrainment caused by the collision between the oil jet and the channel oil at the inlet. The gas phase area ratio in the channel increases with increasing Reynolds number, but its fluctuation is dominated by oscillation frequency. The fluctuation of the gas phase center of gravity becomes larger because of increases in inertial force with increases in oscillation frequency. The average bubble diameter in the channel decreases with increasing Reynolds number and oscillation frequency. We found that bubbles of small diameter are generated because the interfacial fluctuation of the oil jet increases as the jet goes downstream.

This paper discusses the turbulent flow and heat transfer from a uniform air flow with high temperature to the outside through a 90° curved square pipe. Both conjugate heat transfer (CHT) simulation and experiments of temperature field measurements at cross sections of the pipe are performed. A straight pipe is investigated and compared with the 90° curved pipe. The temperature of the air flow at the inlet of the pipe is set at 402 K, and the corresponding Reynolds number is approximately 6 × 104. To obtain the spatial average temperature at each cross section, the temperature fields are measured along the streamwise of the pipes and in the circumferential direction using thermocouples at each cross section from the inlet to the outlet of both the straight and curved pipes. Furthermore, the simulation is performed for turbulent flow and heat transfer inside the pipe wall using the Re-normalization group (RNG) k-ε turbulence model and CHT method. Both the experimental and numerical results show that the curvature of the pipe result in a deviation and impingement in the high-temperature core and a separation between the wall and air, resulting in a secondary flow pattern of the temperature distribution.

The high efficiency cooling of pistons in internal combustion engines by oil jets has recently received widespread attention. To date, curved circular oil jet nozzles have been commonly employed. However, although liquid jets from straight circular nozzles have been studied, there are few reports regarding the characteristics of liquid jets injected by curved circular nozzles. The present work therefore examined the characteristics of oil jets, such as jet width and interfacial fluctuations, following injection via either a 90° curved circular nozzle or straight circular nozzle into a stationary atmosphere. Oil jet parameters were assessed at Reynolds numbers from 1000 to 3000 and the jet interfaces were visualized using a background illumination method in conjunction with a high-speed camera. The oil jet injected from the curved nozzle exhibits more complex behavior compared with that from the straight nozzle. The cross section of the jet from the curved nozzle perpendicular to the direction of movement gradually expanded from a circular shape to an elliptical shape in the downstream direction. The side corresponding to the long diameter of this elliptical jet shape was also observed to switch depending on the Reynolds number. At the inner and outer side interfaces, the outer side interface became larger than the inner side interface at the Reynolds number of 1500 or less. However, the inner side interface became greater than the outer side interface at the Reynolds number of 2000 or more. The effects of the velocity distribution following the bend in the curved nozzle on oil jet behavior were examined by stereoscopic particle image velocimetry. The nozzle internal flow evidently generated movement from the outer side toward the inner side at the Reynolds number of 2000, while flow toward the inner side was dominant when the Reynolds number was 2500.