1. Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro
- Author
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Berrin Tunca, Mevlut Ozgur Taskapilioglu, Secil Ak Aksoy, Gulcin Tezcan, Hasan Kocaeli, Hilal Demirci, Ahmet Bekar, Unal Egeli, Sahsine Tolunay, Gulsah Cecener, Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı., Tezcan, Gülçin, Taşkapılıoğlu, Mevlut Özgür, Tunca, Berrin, Bekar, Ahmet, Demirci, Hilal, Kocaeli, Hasan, Aksoy, Seçil Ak, Egeli, Ünal, Cecener, Gülşah, Tolunay, Şahsine, AAI-1612-2021, AAH-1420-2021, ABB-8161-2020, AAH-3843-2020, AAW-5254-2020, ABI-6078-2020, and AAP-9988-2020
- Subjects
0301 basic medicine ,Vascular Endothelial Growth Factor A ,MMP2 ,Gata6 ,Unclassified drug ,Angiogenesis ,Proliferation ,Expression ,Angiogenesis Inhibitors ,MMP9 ,Cancer Stem Cell ,Insurance Markets ,Operational Risk ,0302 clinical medicine ,Invasion ,Cell Movement ,Olea europaea leaf extract ,Pathology ,Cancer inhibition ,Antiangiogenic activity ,Priority journal ,Tumor ,biology ,Gelatinase A ,Neovascularization, Pathologic ,Plant leaf ,Cell motion ,Drug Synergism ,General Medicine ,Gelatinase B ,Cell invasion ,Plant extract ,Bevacizumab ,Vascular endothelial growth factor A ,Chemistry ,Migration inhibition ,Matrix Metalloproteinase 9 ,Olea ,Mesenchymal transition ,030220 oncology & carcinogenesis ,Antiangiogenic therapies ,Neoplastic Stem Cells ,Matrix Metalloproteinase 2 ,medicine.drug ,Human ,VEGFA ,Tumor invasion ,Vasculotropin A ,Research & experimental medicine ,Drug potentiation ,Angiogenesis inhibitor ,Glioblastoma cancer stem cell ,Article ,03 medical and health sciences ,Antioxidant activity ,Cancer stem cell ,Glioblastoma cell line ,Cell Line, Tumor ,medicine ,Humans ,Neoplasm Invasiveness ,Medicine, research & experimental ,Pharmacology ,Oleuropein ,Drug effects ,Pharmacology & pharmacy ,Plant Extracts ,Cancer ,Polyphenols ,In vitro study ,Tumor cell line ,biology.organism_classification ,medicine.disease ,Plant Leaves ,Drug efficacy ,030104 developmental biology ,Metabolism ,Human cell ,Microrna-153 ,Immunology ,Cancer research ,Olea europaea extract ,Cell line ,Glioblastoma ,Controlled study ,Olive tree ,Neovascularization (pathology) ,Olive oil - Abstract
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.
- Published
- 2017