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23 results on '"Heyer F"'

1. Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study

Author

Heyer, F. L., Heyer, F. L., de Jong, J. J. A., Willems, P. C., Arts, J. J., Bours, S. G. P., van Kuijk, S. M. J., Poeze, M., Geusens, P. P., van Rietbergen, B., van den Bergh, J. P., Heyer, F. L., Heyer, F. L., de Jong, J. J. A., Willems, P. C., Arts, J. J., Bours, S. G. P., van Kuijk, S. M. J., Poeze, M., Geusens, P. P., van Rietbergen, B., and van den Bergh, J. P.

Abstract

Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters.HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (FEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100.Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R-2: 0.49, p = 0.006 and R-2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome.This exploratory study indicates that HR-pQCT with mu FEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.

Published
2019

23. Large cortical bone pores in the tibia are associated with proximal femur strength.

Author

Iori G, Schneider J, Reisinger A, Heyer F, Peralta L, Wyers C, Gräsel M, Barkmann R, Glüer CC, van den Bergh JP, Pahr D, and Raum K

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Porosity, Absorptiometry, Photon, Bone Density, Cortical Bone diagnostic imaging, Cortical Bone metabolism, Femur Neck diagnostic imaging, Femur Neck metabolism, Tibia diagnostic imaging, Tibia metabolism, X-Ray Microtomography
Abstract

Alterations of structure and density of cortical bone are associated with fragility fractures and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women have been recently linked to an increase in size of cortical pores. In this ex vivo study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged 69 to 94 years) to address, whether this can reflect impairments of the mechanical competence of the proximal femur, i.e., a major fracture site in osteoporosis. Scanning acoustic microscopy (12 μm pixel size) provided reference microstructural measurements at the left tibia, while the bone vBMD at this site was obtained using microcomputed tomography (microCT). The areal bone mineral density of both left and right femoral necks (aBMDneck) was measured by dual-energy X-ray absorptiometry (DXA), while homogenized nonlinear finite element models based on high-resolution peripheral quantitative computed tomography provided hip stiffness and strength for one-legged standing and sideways falling loads. Hip strength was associated with aBMDneck (r = 0.74 to 0.78), with tibial cortical thickness (r = 0.81) and with measurements of the tibial cross-sectional geometry (r = 0.48 to 0.73) of the same leg. Tibial vBMD was associated with hip strength only for standing loads (r = 0.59 to 0.65). Cortical porosity (Ct.Po) of the tibia was not associated with any of the femoral parameters. However, the proportion of Ct.Po attributable to large pores (diameter > 100 μm) was associated with hip strength in both standing (r = -0.61) and falling (r = 0.48) conditions. When added to aBMDneck, the prevalence of large pores could explain up to 17% of the femur ultimate force. In conclusion, microstructural characteristics of the tibia reflect hip strength as well as femoral DXA, but it remains to be tested whether such properties can be measured in vivo., Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: GI and KR have the patent "CortBS: Ultrasonic method for determining pore dimensions in cortical bone" pending. JB reports grants and personal fees from Eli Lilly, Amgen and Will Pharma, outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Published
2019
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