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4. Primary resistance to immunotherapy in patients with a dMMR/MSI metastatic gastrointestinal cancer: who is at risk? An AGEO real-world study

Author

Flecchia, Clémence, Auclin, Edouard, Alouani, Emily, Mercier, Mathilde, Hollebecque, Antoine, Turpin, Anthony, Mazard, Thibault, Pernot, Simon, Dutherage, Marie, Cohen, Romain, Borg, Christophe, Hautefeuille, Vincent, Sclafani, Francesco, Ben-Abdelghani, Meher, Aparicio, Thomas, De La Fouchardière, Christelle, Herve, Camille, Perkins, Geraldine, Heinrich, Kathrin, Kunzmann, Volker, Gallois, Claire, Guimbaud, Rosine, Tougeron, David, and Taieb, Julien

Published
2024
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5. Utility of clinical and MR imaging parameters for prediction and monitoring of response to capecitabine and temozolomide (CAPTEM) therapy in patients with liver metastases of neuroendocrine tumors

Author

Ingenerf Maria, Auernhammer Christoph, Lorbeer Roberto, Winkelmann Michael, Mansournia Shiwa, Mansour Nabeel, Hesse Nina, Heinrich Kathrin, Ricke Jens, Berger Frank, and Schmid-Tannwald Christine

Subjects
neuroendocrine tumors, liver metastases, captem therapy, clinical parameters, mr imaging, treatment response, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET).

Published
2024
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7. Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)

Author

Ababei, Juliana, Alt, Jürgen, Ammon, Andreas, Anhuf, Jürgen, Azeh, Ivo, Bauer, Stefan, Behringer, Dirk, Berger, Winfried, Bernhardt, Christiane, Bertram, Mathias, Boesche, Michael, Bohnet, Sabine, Bruch, Harald-Robert, Brückl, Wolfgang, Burkhard-Meier, Ulrike, Christopoulos, Petros, Däßler, Klaus-Ulrich, de Wit, Maike, Dechow, Tobias, Depenbusch, Reinhard, Dietze, Lutz, Dommach, Markus, Dörfel, Steffen, Eberhardt, Wilfried, Elender, Corinna, Elsel, Wolfgang, Emde, Till-Oliver, Faehling, Martin, Fietz, Thomas, Fischer, Jürgen R., Flieger, Dimitri, Freidt, Anke, Freier, Werner, Frenzel, Christian, Fuchs, Florian, Fuchs, Roswitha, Gaska, Tobias, Gleiber, Wolfgang, Grah, Christian, Griesinger, Frank, Grohé, Christian, Groschek, Matthias, Güldenzoph, Björn, Günther, Andreas, Haas, Siegfried, Hackenthal, Matthias, Hagen, Volker, Hahn, Lars, Hannig Carla, Verena, Hansen, Richard, Harich, Hanns-Detlev, Heilmann, Monika, Heinrich, Kathrin, Hering-Schubert, Christiane, Heßling, Jörg, Hoffknecht, Petra, Hortig, Patricia, Hübner, Gerdt, Hummel, Horst-Dieter, Hutzschenreuter, Ulrich, Illmer, Thomas, Innig, Georg, Jaeschke, Bastian, Junghanß, Christian, Kaiser, Ulrich, Kamal, Haytham, Kambartel, Kato, Kern, Jens, Kimmich, Martin, Kingreen, Dorothea, Kirchen, Heinz, Klausmann, Martine, Klein, Ortwin, Kokowski, Konrad, Körber, Wolfgang, Kortsik, Cornelius, Koschel, Dirk, Krämer, Benoit, Krammer-Steiner, Beate, Laack, Eckart, Lamberti, Christof, Leistner, Rumo David, Losem, Christoph, Lück, Andreas, Maintz, Christoph, Martin, Kerstin, Medgenberg, Dirk, Metzenmacher, Martin, Meyer zum Büschenfelde, Christian, Meyn, Philipp, Moorahrend, Enno, Müller, Annette, Müller, Lothar, Neise, Michael, Nückel, Holger, Nusch, Arnd, Overbeck, Tobias, Pelz, Henning, Petersen, Volker, Peuser, Bettina, Plath, Margarete, Randerath, Winfried J., Rauh, Jacqueline, Reck, Martin, Reichert, Dietmar, Reinmuth, Niels, Reiser, Marcel, Repp, Roland, Reschke, Daniel, Rittmeyer, Achim, Rodemer, Yolanda, Sackmann, Sandra, Sadjadian, Parvis, Sandner, Reiner, Sauer, Annette, Schäfer, Harald, Schaudt, Christoph, Schlag, Rudolf, Schmidt, Burkhard, Schmitz, Stephan, Schröder, Jan, Schroeder, Michael, Schulze, Mathias, Schumann, Christian, Schütte, Wolfgang, Schwaiblmair, Martin, Schwindt Peter, Florian, Sebastian, Martin, Seese, Bernd, Seipelt, Gernot, Sorgenfrei, Thomas, Steiff, Johannes, Steiniger, Heike, Trarbach, Tanja, Tufman, Amanda, Uhlig, Jens, Vehling-Kaiser, Ursula, von der Heyde, Eyck, von Verschuer, Ulla, Waller, Cornelius, Wehler, Thomas, Weißenborn, Georg, Weißinger, Florian, Wermke, Martin, Wesseler, Claas, Wiegand, Jörg, Wilhelm, Stefan, Wilke, Jochen, Zahn, Mark-Oliver, Zaiss, Matthias, Zeth, Matthias, Eberhardt, Wilfried E.E., Brueckl, Wolfgang M., Jänicke, Martina, Fleitz, Annette, Zacharias, Stefan, Hipper, Annette, Groth, Annika, Weichert, Wilko, and Thomas, Michael

Published
2024
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8. Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3

Author

Fischer, Laura E., Stintzing, Sebastian, von Weikersthal, Ludwig Fischer, Modest, Dominik P., Decker, Thomas, Kiani, Alexander, Kaiser, Florian, Al-Batran, Salah-Eddin, Heintges, Tobias, Lerchenmüller, Christian, Kahl, Christoph, Seipelt, Gernot, Kullmann, Frank, Stauch, Martina, Scheithauer, Werner, Giessen-Jung, Clemens, Uhlig, Jens, Peuser, Bettina, Denzlinger, Claudio, Stahler, Arndt, Weiss, Lena, Heinrich, Kathrin, Held, Swantje, Jung, Andreas, Kirchner, Thomas, and Heinemann, Volker

Published
2022
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9. Genetics and beyond: Precision Medicine Real-World Data for Patients with Cervical, Vaginal or Vulvar Cancer in a Tertiary Cancer Center

Author

Kraus, Fabian B. T., primary, Sultova, Elena, additional, Heinrich, Kathrin, additional, Jung, Andreas, additional, Westphalen, C. Benedikt, additional, Tauber, Christina V., additional, Kumbrink, Jörg, additional, Rudelius, Martina, additional, Klauschen, Frederick, additional, Greif, Philipp A., additional, König, Alexander, additional, Chelariu-Raicu, Anca, additional, Czogalla, Bastian, additional, Burges, Alexander, additional, Mahner, Sven, additional, Wuerstlein, Rachel, additional, and Trillsch, Fabian, additional

Published
2024
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10. Understanding communication between patients and healthcare professionals regarding comprehensive biomarker testing in precision oncology: A scoping review

Author

Pichler, Theresia, primary, Mumm, Friederike, additional, Dehar, Navdeep, additional, Dickman, Erin, additional, Díez de Los Ríos de la Serna, Celia, additional, Dinkel, Andreas, additional, Heinrich, Kathrin, additional, Hennink, Merel, additional, Parviainen, Anndra D., additional, Raske, Vincent, additional, Wicki, Nicole, additional, and Moore, Amy C., additional

Published
2024
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11. INNV-06. SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION-MAKING IN RECURRENT GLIOMA

Author

Blobner, Jens, primary, Dengler, Laura, additional, Blobner, Sven, additional, Eberle, Constantin, additional, Weller, Jonathan, additional, Teske, Nico, additional, Karschnia, Philipp, additional, Ruehlmann, Katharina, additional, Heinrich, Kathrin, additional, Ziemann, Frank, additional, Greif, Philipp, additional, Jeremias, Irmela, additional, Wuerstlein, Rachel, additional, Hasselmann, Korbinian, additional, Dorostkar, Mario, additional, Harter, Patrick, additional, Quach, Stefanie, additional, Stoecklein, Veit, additional, Albert, Nathalie, additional, Niyazi, Maximilian, additional, Tonn, Joerg-Christian, additional, Thon, Niklas, additional, Westphalen, Benedikt, additional, and von Baumgarten, Louisa, additional

Published
2023
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12. OncoAlert Round Table Discussions: The Global COVID-19 Experience

Author

Morgan, Gilberto, de Azambuja, Evandro, Punie, Kevin, Ades, Felipe, Heinrich, Kathrin, Personeni, Nicola, Rahme, Ramy, Ferrara, Roberto, Pels, Kevin, Garassino, Marina, von Bergwelt-Baildon, Michael, Lopes, Gilberto, Barlesi, Fabrice, Choueiri, Toni K., Burris, Howard, and Peters, Solange

Published
2021
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14. Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma

Author

Blobner, Jens, primary, Dengler, Laura, additional, Blobner, Sven, additional, Eberle, Constantin, additional, Weller, Jonathan, additional, Teske, Nico, additional, Karschnia, Philipp, additional, Rühlmann, Katharina, additional, Heinrich, Kathrin, additional, Ziemann, Frank, additional, Greif, Philipp A, additional, Jeremias, Irmela, additional, Wuerstlein, Rachel, additional, Hasselmann, Korbinian, additional, Dorostkar, Mario, additional, Harter, Patrick N, additional, Quach, Stefanie, additional, Stoecklein, Veit, additional, Albert, Nathalie L, additional, Niyazi, Maximilian, additional, Tonn, Joerg-Christian, additional, Thon, Niklas, additional, Westphalen, Benedikt Christoph, additional, and von Baumgarten, Louisa, additional

Published
2023
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17. Prognostic factors in non-small-cell lung cancer: insights from the German crisp registry

Author

Griesinger, Frank, Hummel, Horst-Dieter, Schäfer, Harald, de Wit, Maike, Kaiser, Ulrich, Kern, Jens, Jänicke, Martina, Spring, Lisa, Zacharias, Stefan, Kaiser-Osterhues, Anja, Groth, Annika, Hipper, Annette, Zaun, Gregor, Müller, Lothar, Uhlig, Jens, Thomas, Michael, Sebastian, Martin, Eberhardt, Wilfried, Ababei, Juliana, Alt, Jürgen, Ammon, Andreas, Anhuf, Jürgen, Azeh, Ivo, Bauer, Stefan, Behringer, Dirk, Berger, Winfried, Bernhardt, Christiane, Bertram, Mathias, Boesche, Michael, Bohnet, Sabine, Bruch, Harald-Robert, Brückl, Wolfgang, Burkhard-Meier, Ulrike, Christopoulos, Petros, Däßler, Klaus-Ulrich, Dechow, Tobias, Depenbusch, Reinhard, Dietze, Lutz, Dommach, Markus, Dörfel, Steffen, Elender, Corinna, Elsel, Wolfgang, Emde, Till-Oliver, Faehling, Martin, Fietz, Thomas, Fischer, Jürgen R., Flieger, Dimitri, Freidt, Anke, Freier, Werner, Frenzel, Christian, Fuchs, Florian, Fuchs, Roswitha, Gaska, Tobias, Gleiber, Wolfgang, Grah, Christian, Grohé, Christian, Groschek, Matthias, Güldenzoph, Björn, Günther, Andreas, Haas, Siegfried, Hackenthal, Matthias, Hagen, Volker, Hahn, Lars, Hannig, Carla Verena, Hansen, Richard, Harich, Hanns-Detlev, Heilmann, Monika, Heinrich, Kathrin, Hering-Schubert, Christiane, Heßling, Jörg, Hoffknecht, Petra, Hortig, Patricia, Hübner, Gerdt, Hutzschenreuter, Ulrich, Illmer, Thomas, Innig, Georg, Jaeschke, Bastian, Junghanß, Christian, Kamal, Haytham, Kambartel, Kato, Kimmich, Martin, Kingreen, Dorothea, Kirchen, Heinz, Klausmann, Martine, Klein, Ortwin, Kokowski, Konrad, Körber, Wolfgang, Kortsik, Cornelius, Koschel, Dirk, Krämer, Benoit, Krammer-Steiner, Beate, Laack, Eckart, Lamberti, Christof, Leistner, Rumo David, Losem, Christoph, Lück, Andreas, Maintz, Christoph, Martin, Kerstin, Medgenberg, Dirk, Metzenmacher, Martin, Meyer zum Büschenfelde, Christian, Meyn, Philipp, Moorahrend, Enno, Müller, Annette, Neise, Michael, Nückel, Holger, Nusch, Arnd, Overbeck, Tobias, Pelz, Henning, Petersen, Volker, Peuser, Bettina, Plath, Margarete, Randerath, Winfried J., Rauh, Jacqueline, Reck, Martin, Reichert, Dietmar, Reinmuth, Niels, Reiser, Marcel, Repp, Roland, Reschke, Daniel, Rittmeyer, Achim, Rodemer, Yolanda, Sackmann, Sandra, Sadjadian, Parvis, Sandner, Reiner, Sauer, Annette, Schaudt, Christoph, Schlag, Rudolf, Schmidt, Burkhard, Schmitz, Stephan, Schröder, Jan, Schroeder, Michael, Schulze, Mathias, Schumann, Christian, Schütte, Wolfgang, Schwaiblmair, Martin, Schwindt, Peter Florian, Seese, Bernd, Seipelt, Gernot, Sorgenfrei, Thomas, Steiff, Johannes, Steiniger, Heike, Trarbach, Tanja, Tufman, Amanda, Vehling-Kaiser, Ursula, von der Heyde, Eyck, von Verschuer, Ulla, Waller, Cornelius, Wehler, Thomas, Weißenborn, Georg, Weißinger, Florian, Wermke, Martin, Wesseler, Claas, Wiegand, Jörg, Wilhelm, Stefan, Wilke, Jochen, Zahn, Mark-Oliver, Zaiss, Matthias, and Zeth, Matthias

Subjects
Pulmonary and Respiratory Medicine, Medizin
Abstract

IntroductionUnderstanding prognosis, especially long-term outcome, in advanced nonsmall cell lung cancer (NSCLC) is crucial to inform patients, guide treatment and plan supportive and palliative care.MethodsPrognostic factors influencing overall survival (OS) and progression-free survival (PFS) in 2082 patients with wild-type (WT)-NSCLC (629 M1a, 249 M1b, 1204 M1c) are reported. Patients were included in the prospective German CRISP registry recruiting in >150 centres. Analysis for pre-therapeutic factors was based on results from Cox proportional hazard models.ResultsCurrent M-descriptors of the Union for International Cancer Control-8 staging system were validated: M1a and M1b patients had significantly longer median time to events compared to M1c (OS/PFS 16.4/7.2 months, 17.8/6.7 months and 10.9/5.4 months, respectively). OS and PFS were influenced by number and location of metastatic organ systems. M1c and four or more metastatic organs involved had shorter OS and PFS than M1c with one to three organs (OS hazard ratio (HR) 1.69, pConclusionIn this large observational dataset, we further defined factors for outcome in WT-NSCLC, including increased number of involved metastatic organ systems and liver metastases, as those with overall poorer prognosis and reduced survival chance.

Published
2022

18. Response and Disease Dynamics in Untreated Metastatic Colorectal Cancer With Bevacizumab-Based Sequential vs. Combination Chemotherapy—Analysis of the Phase 3 XELAVIRI Trial

Author

Kurreck, Annika, primary, Heinemann, Volker, additional, Fischer von Weikersthal, Ludwig, additional, Decker, Thomas, additional, Kaiser, Florian, additional, Uhlig, Jens, additional, Schenk, Michael, additional, Freiberg-Richter, Jens, additional, Peuser, Bettina, additional, Denzlinger, Claudio, additional, Graeven, Ullrich, additional, Heinrich, Kathrin, additional, Held, Swantje, additional, Stahler, Arndt, additional, Alig, Annabel Helga Sophie, additional, Jelas, Ivan, additional, von Einem, Jobst C., additional, Stintzing, Sebastian, additional, Giessen-Jung, Clemens, additional, and Modest, Dominik P., additional

Published
2022
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19. Exact Primary Tumor Location in mCRC: Prognostic Value and Predictive Impact on Anti-EGFR mAb Efficacy

Author

Alig, Annabel H. S., primary, Heinemann, Volker, additional, Geissler, Michael, additional, Fischer von Weikersthal, Ludwig, additional, Decker, Thomas, additional, Heinrich, Kathrin, additional, Held, Swantje, additional, Weiss, Lena, additional, Fischer, Laura E., additional, Moosmann, Nicolas, additional, Stahler, Arndt, additional, Jelas, Ivan, additional, Kurreck, Annika, additional, von Einem, Jobst C., additional, Reinacher-Schick, Anke C., additional, Tannapfel, Andrea, additional, Giessen-Jung, Clemens, additional, Stintzing, Sebastian, additional, and Modest, Dominik P., additional

Published
2022
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21. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

Author

Besler, Christian, Heinrich, Kathrin, Rohrer, Lucia, Doerries, Carola, Riwanto, Meliana, Shih, Diana M., Chroni, Angeliki, Yonekawa, Keiko, Stein, Sokrates, Schaefer, Nicola, Mueller, Maja, Akhmedov, Alexander, Daniil, Georgios, Manes, Costantina, Templin, Christian, Wyss, Christophe, Maier, Willibald, Tanner, Felix C., Matter, Christian M., Corti, Roberto, Furlong, Clement, Lusis, Aldons J., Eckardstein, Arnold von, Fogelman, Alan M., Luscher, Thomas F., and Landmesser, Ulf

Subjects
Coronary heart disease -- Care and treatment -- Prevention -- Research, High density lipoproteins -- Physiological aspects -- Research, Endothelium -- Physiological aspects -- Research, Enzymes -- Physiological aspects -- Research, Health care industry
Abstract

Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or prevention of coronary artery disease (CAD). [...]

Published
2011
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22. Factors That Influence Conversion to Resectability and Survival After Resection of Metastases in RAS WT Metastatic Colorectal Cancer (mCRC): Analysis of FIRE-3-AIOKRK0306

Author

Modest, Dominik Paul, Heinemann, Volker, Folprecht, Gunnar, Denecke, Timm, Pratschke, Johann, Lang, Hauke, Bemelmans, Marc, Becker, Thomas, Rentsch, Markus, Seehofer, Daniel, Bruns, Christiane J., Gebauer, Bernhard, Held, Swantje, Stahler, Arndt, Heinrich, Kathrin, von Einem, Jobst C., Stintzing, Sebastian, Neumann, Ulf P., Ricard, Ingrid, Modest, Dominik Paul, Heinemann, Volker, Folprecht, Gunnar, Denecke, Timm, Pratschke, Johann, Lang, Hauke, Bemelmans, Marc, Becker, Thomas, Rentsch, Markus, Seehofer, Daniel, Bruns, Christiane J., Gebauer, Bernhard, Held, Swantje, Stahler, Arndt, Heinrich, Kathrin, von Einem, Jobst C., Stintzing, Sebastian, Neumann, Ulf P., and Ricard, Ingrid

Abstract

Background Tumor assessments after first-line therapy ofRASwild-type mCRC with cetuximab (cet) versus bevacizumab (bev) in combination with FOLFIRI were evaluated for factors influencing resectability, conversion to resectability, and survival after best response. Methods Conversion to resectability was defined as conversion of initially unresectable to resectable disease at best response as determined by retrospective assessment. Univariate and multivariate logistic models were fitted with resectability at best response as response variable. A Cox model comparing the survival from best response was used to measure the influence of treatment, resectability at best response, and resection. Interaction of resection and treatment arm on survival was tested by likelihood ratio test. Results Overall, 270 patients were evaluable (127 cet-arm, 143 bev-arm). Lung metastases (odds ratio [OR] 0.35, 95% confidence response [CI] 0.19-0.63),BRAFmutation (OR 0.33, 95% CI 0.12-0.82), and elevated alkaline phosphatase (OR 0.42, 95% CI 0.18-0.9) before randomization were associated with less chance of successful conversion and were integrated into a nomogram. Early tumor shrinkage (OR 1.86, 95% CI 1.06-3.3;p 0.034) and depth of response (OR 1.02, 95% CI 1.01-1.03;p < 0.001) were associated with successful conversion therapy. Resection of metastases improved post-best-response survival (hazard ratio 0.53, 95% CI 0.29-0.97;p = 0.039), predominantely in cet-treated patients (interaction test,p = 0.02). Conclusions Conversion to resectability is significantly associated with baseline characteristics that can be used in a nomogram to predict conversion. Moreover, early efficacy parameters (ETS and DpR) are associated with successful conversion therapy. In FIRE-3, resection of metastases was associated with improved post-best response survival, this effect originated predominantly from the cetuximab-based study arm.

Published
2020

24. Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)

Author

Griesinger, Frank, Sebastian, Martin, Brueckl, Wolfgang M., Hummel, Horst-Dieter, Jaeschke, Bastian, Kern, Jens, Wesseler, Claas, Jänicke, Martina, Fleitz, Annette, Zacharias, Stefan, Hipper, Annette, Groth, Annika, Weichert, Wilko, Dörfel, Steffen, Petersen, Volker, Schröder, Jan, Wilke, Jochen, Eberhardt, Wilfried E.E., Thomas, Michael, Ababei, Juliana, Alt, Jürgen, Ammon, Andreas, Anhuf, Jürgen, Azeh, Ivo, Bauer, Stefan, Behringer, Dirk, Berger, Winfried, Bernhardt, Christiane, Bertram, Mathias, Boesche, Michael, Bohnet, Sabine, Bruch, Harald-Robert, Brückl, Wolfgang, Burkhard-Meier, Ulrike, Christopoulos, Petros, Däßler, Klaus-Ulrich, de Wit, Maike, Dechow, Tobias, Depenbusch, Reinhard, Dietze, Lutz, Dommach, Markus, Dörfel, Steffen, Eberhardt, Wilfried, Elender, Corinna, Elsel, Wolfgang, Emde, Till-Oliver, Faehling, Martin, Fietz, Thomas, Fischer, Jürgen R., Flieger, Dimitri, Freidt, Anke, Freier, Werner, Frenzel, Christian, Fuchs, Florian, Fuchs, Roswitha, Gaska, Tobias, Gleiber, Wolfgang, Grah, Christian, Griesinger, Frank, Grohé, Christian, Groschek, Matthias, Güldenzoph, Björn, Günther, Andreas, Haas, Siegfried, Hackenthal, Matthias, Hagen, Volker, Hahn, Lars, Hannig Carla, Verena, Hansen, Richard, Harich, Hanns-Detlev, Heilmann, Monika, Heinrich, Kathrin, Hering-Schubert, Christiane, Heßling, Jörg, Hoffknecht, Petra, Hortig, Patricia, Hübner, Gerdt, Hummel, Horst-Dieter, Hutzschenreuter, Ulrich, Illmer, Thomas, Innig, Georg, Jaeschke, Bastian, Junghanß, Christian, Kaiser, Ulrich, Kamal, Haytham, Kambartel, Kato, Kern, Jens, Kimmich, Martin, Kingreen, Dorothea, Kirchen, Heinz, Klausmann, Martine, Klein, Ortwin, Kokowski, Konrad, Körber, Wolfgang, Kortsik, Cornelius, Koschel, Dirk, Krämer, Benoit, Krammer-Steiner, Beate, Laack, Eckart, Lamberti, Christof, Leistner, Rumo David, Losem, Christoph, Lück, Andreas, Maintz, Christoph, Martin, Kerstin, Medgenberg, Dirk, Metzenmacher, Martin, Meyer zum Büschenfelde, Christian, Meyn, Philipp, Moorahrend, Enno, Müller, Annette, Müller, Lothar, Neise, Michael, Nückel, Holger, Nusch, Arnd, Overbeck, Tobias, Pelz, Henning, Petersen, Volker, Peuser, Bettina, Plath, Margarete, Randerath, Winfried J., Rauh, Jacqueline, Reck, Martin, Reichert, Dietmar, Reinmuth, Niels, Reiser, Marcel, Repp, Roland, Reschke, Daniel, Rittmeyer, Achim, Rodemer, Yolanda, Sackmann, Sandra, Sadjadian, Parvis, Sandner, Reiner, Sauer, Annette, Schäfer, Harald, Schaudt, Christoph, Schlag, Rudolf, Schmidt, Burkhard, Schmitz, Stephan, Schröder, Jan, Schroeder, Michael, Schulze, Mathias, Schumann, Christian, Schütte, Wolfgang, Schwaiblmair, Martin, Schwindt Peter, Florian, Sebastian, Martin, Seese, Bernd, Seipelt, Gernot, Sorgenfrei, Thomas, Steiff, Johannes, Steiniger, Heike, Trarbach, Tanja, Tufman, Amanda, Uhlig, Jens, Vehling-Kaiser, Ursula, von der Heyde, Eyck, von Verschuer, Ulla, Waller, Cornelius, Wehler, Thomas, Weißenborn, Georg, Weißinger, Florian, Wermke, Martin, Wesseler, Claas, Wiegand, Jörg, Wilhelm, Stefan, Wilke, Jochen, Zahn, Mark-Oliver, Zaiss, Matthias, and Zeth, Matthias

Abstract

Patients with metastatic NSCLC (mNSCLC) treated with immune checkpoint inhibitors in clinical practice may often not meet the strict inclusion criteria of clinical trials. Our aim was to assess the trial eligibility of patients with mNSCLC treated with pembrolizumab monotherapy in real-world and to compare the outcome of “trial-ineligible” and “potentially trial-eligible” patients.

Published
2024
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27. Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

Author

Riwanto, Meliana, primary, Rohrer, Lucia, additional, Roschitzki, Bernd, additional, Besler, Christian, additional, Mocharla, Pavani, additional, Mueller, Maja, additional, Perisa, Damir, additional, Heinrich, Kathrin, additional, Altwegg, Lukas, additional, von Eckardstein, Arnold, additional, Lüscher, Thomas F., additional, and Landmesser, Ulf, additional

Published
2013
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29. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

Author

Stein, Sokrates, primary, Schäfer, Nicola, additional, Breitenstein, Alexander, additional, Besler, Christian, additional, Winnik, Stephan, additional, Lohmann, Christine, additional, Heinrich, Kathrin, additional, Brokopp, Chad E., additional, Handschin, Christoph, additional, Landmesser, Ulf, additional, Tanner, Felix C., additional, Lüscher, Thomas F., additional, and Matter, Christian M., additional

Published
2010
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30. Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

Author

Sorrentino, Sajoscha A., primary, Besler, Christian, additional, Rohrer, Lucia, additional, Meyer, Martin, additional, Heinrich, Kathrin, additional, Bahlmann, Ferdinand H., additional, Mueller, Maja, additional, Horváth, Tibor, additional, Doerries, Carola, additional, Heinemann, Mariko, additional, Flemmer, Stella, additional, Markowski, Andrea, additional, Manes, Costantina, additional, Bahr, Matthias J., additional, Haller, Hermann, additional, von Eckardstein, Arnold, additional, Drexler, Helmut, additional, and Landmesser, Ulf, additional

Published
2010
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31. Abstract 4870: Mechanisms Leading to Impaired Endothelial-vasoprotective Properties of High Density Lipoprotein (HDL) in Patients With Coronary Disease (CAD)

Author

Besler, Christian, primary, Heinrich, Kathrin, additional, Rohrer, Lucia, additional, Yonekawa, Keiko, additional, Doerries, Carola, additional, Manes, Costantina, additional, Müller, Maja, additional, Templin, Christian, additional, Corti, Roberto, additional, Maier, Willibald, additional, Wyss, Christophe, additional, Alibegovic, Jasmina, additional, Kucher, Nils, additional, von Eckardstein, Arnold, additional, Luscher, Thomas F, additional, and Landmesser, Ulf, additional

Published
2009
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