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1. Physiological Changes with Periodized Resistance Training in Women Tennis Players

Author

KRAEMER, WILLIAM J., HÄKKINEN, KEIJO, TRAVIS TRIPLETT-MCBRIDE, N., FRY, ANDREW C., PERRY KOZIRIS, L., RATAMESS, NICHOLAS A., BAUER, JEFFREY E., VOLEK, JEFF S., MCCONNELL, TIM, NEWTON, ROBERT U., GORDON, SCOTT E., CUMMINGS, DON, HAUTH, JOHN, PULLO, FRANK, MICHAEL LYNCH, J., MAZZETTI, SCOTT A., and KNUTTGEN, HOWARD G.

Published
2003

2. Does C-Reactive Protein Predict Recurrent Preeclampsia?

Author

Gammill, Hilary S., Powers, Robert W., Clifton, Rebecca G., Van Dorsten, J. Peter, Hauth, John C., Klebanoff, Mark A., Lindheimer, Marshall D., Sibai, Baha, Landon, Mark, Miodovnik, Menachem, and Dombrowski, Mitchell

Subjects
Adult, medicine.medical_specialty, Enzyme-Linked Immunosorbent Assay, Gastroenterology, Article, Preeclampsia, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Recurrence, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, reproductive and urinary physiology, Inflammation, Aspirin, Chi-Square Distribution, biology, Obstetrics, business.industry, C-reactive protein, Acute-phase protein, Obstetrics and Gynecology, medicine.disease, female genital diseases and pregnancy complications, C-Reactive Protein, Predictive value of tests, embryonic structures, biology.protein, Gestation, Female, business, Chi-squared distribution, Biomarkers, medicine.drug
Abstract

Objective. Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia. Methods. Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP. Results. Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence. Conclusion. In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.

Published
2010

3. First-Trimester Prediction of Preeclampsia in Low-Risk Nulliparous Women

Author

Myatt, Leslie, Clifton, Rebecca G., Roberts, James M., Spong, Catherine Y., Hauth, John C., Varner, Michael W., Thorp, John M., Mercer, Brian M., Peaceman, Alan M., Ramin, Susan M., Carpenter, Marshall W., Iams, Jay D., Sciscione, Anthony, Harper, Margaret, Tolosa, Jorge E., Saade, George, Sorokin, Yoram, and Anderson, Garland D.

Subjects
Adult, Risk, Vascular Endothelial Growth Factor Receptor-1, Galectins, Endoglin, ADAM12 Protein, Black People, Membrane Proteins, Receptors, Cell Surface, Pregnancy Proteins, Models, Biological, Article, ADAM Proteins, Parity, Pregnancy Trimester, First, Young Adult, Pre-Eclampsia, Antigens, CD, Pregnancy, Case-Control Studies, Humans, Pregnancy-Associated Plasma Protein-A, Female, Biomarkers, Placenta Growth Factor
Abstract

To identify clinical characteristics and biochemical markers in first-trimester samples that would possibly predict the subsequent development of preeclampsia.We conducted a multicenter observational study in 2,434 nulliparous women at low risk to identify biomarkers that possibly predict preeclampsia. Clinical history, complete blood count, and biochemical markers were assessed in the first trimester. The trophoblast and angiogenesis markers ADAM-12, pregnancy-associated plasma protein-A, placental protein 13, placental growth factor, soluble fms-like tyrosine kinase-1, and endoglin were measured in a case-control subset of 174 women with preeclampsia and 509 women in the control group.Univariable analysis revealed maternal age, race, marital status, years of education, source of medical payment, prenatal caregiver, body mass index (BMI, calculated as weight (kg)/[height (m)]), and systolic blood pressure at enrollment were significantly associated with preeclampsia. Mean platelet volume was greater at enrollment in women who later had development of preeclampsia (median 9.4 compared with 9.0 femtoliter (fl); P=.02). First-trimester concentrations (multiples of the median) of ADAM-12 (1.14 compared with 1.04; P=.003), pregnancy-associated plasma protein-A (0.94 compared with 0.98; P=.04), and placental growth factor (0.83 compared with 1.04; P.001) were significantly different in women who had development of preeclampsia compared with women in the control group. The optimal multivariable model included African American race, systolic blood pressure, BMI, education level, ADAM-12, pregnancy-associated plasma protein-A, and placental growth factor, and yielded an area under the curve of 0.73 (95% confidence interval 0.69-0.77) and a sensitivity of 46.1% (95% confidence interval 38.3-54.0) for 80% specificity.A multivariable analysis of clinical data and biochemical markers in the first trimester did not identify a model that had clinical utility for predicting preeclampsia in a nulliparous population at low risk.II.

Published
2012

4. Physiological Changes With Periodized Resistance Training in Women Tennis Players

Author

Kraemer, William J, Kraemer, William J, Hakkinen, Keijo, Triplett-McBride, Travis, Fry, Andrew C, Koziris, L. Perry, Ratamess, Nicholas A, Bauer, Jeffery E, Volek, Jeff S, McConnell, Tim, Newton, Robert U, Gordon, Scott E, Cummings, Don, Hauth, John, Pullo, Frank, Lynch, J Michael, Mazzetti, Scott A, Knuttgen, Howard G, Kraemer, William J, Kraemer, William J, Hakkinen, Keijo, Triplett-McBride, Travis, Fry, Andrew C, Koziris, L. Perry, Ratamess, Nicholas A, Bauer, Jeffery E, Volek, Jeff S, McConnell, Tim, Newton, Robert U, Gordon, Scott E, Cummings, Don, Hauth, John, Pullo, Frank, Lynch, J Michael, Mazzetti, Scott A, and Knuttgen, Howard G

Abstract

Purpose: To compare the physiological and performance adaptations between periodized and nonperiodized resistance training in women collegiate tennis athletes. Methods: Thirty women (19 ± 1 yr) were assigned to either a periodized resistance training group (P), nonperiodized training group (NV), or a control group (C). Assessments for body composition, anaerobic power, V̇O2max, speed, agility, maximal strength, jump height, tennis-service velocity, and resting serum hormonal concentrations were performed before and after 4, 6, and 9 months of resistance training performed 2-3 d∙wk-1 Results: Nine months of resistance training resulted in significant increases in fat-free mass; anaerobic power; grip strength; jump height; one-repetition maximum (1-RM) leg press, bench press, and shoulder press; serve, forehand, and backhand ball velocities; and resting serum insulin-like growth factor-1, testosterone, and cortisol concentrations. Percent body fat and V̇O2max decreased significantly in the P and NV groups after training. During the first 6 months, periodized resistance training elicited significantly greater increases in 1-RM leg press (9 ± 2 vs 4.5 ± 2%), bench press (22 ± 5 vs 11 ± 8%), and shoulder press (24 ± 7 vs 18 ± 6%) than the NV group. The absolute 1-RM leg press and shoulder press values in the P group were greater than the NV group after 9 months. Periodized resistance training also resulted in significantly greater improvements in jump height (50 ± 9 vs 37 ± 7%) and serve (29 ± 5 vs 16 ± 4%), forehand (22 ± 3 vs 17 ± 3%), and backhand ball velocities (36 ± 4 vs 14 ± 4%) as compared with nonperiodized training after 9 months. Conclusions: These data demonstrated that periodization of resistance training over 9 months was superior for enhancing strength and motor performance in collegiate women tennis players. Reprinted by permission of the publisher.

Published
2003

5. 19: Maternal insulin resistance and preeclampsia

Author

Hauth, John C.

Subjects
embryonic structures, Obstetrics and Gynecology, reproductive and urinary physiology, female genital diseases and pregnancy complications
Abstract

To determine whether midtrimester insulin resistance (IR) is associated with subsequent preeclampsia.

Published
2011

7. Maternal plasma concentrations of the soluble tumor necrosis factor receptor 2 are increased prior to the diagnosis of preeclampsia

Author

Sibai, Baha, Romero, Roberto, Klebanoff, Mark A., Rice, Madeline Murguia, Caritis, Steve, Hauth, John, Lindheimer, Marshall D., Van Dorsten, Peter, Landon, Mark, Miodovnik, Menachem, Paul, Richard, Dombrowski, Mitchell, Meis, Paul, and Thurnau, Gary

Subjects
Adult, medicine.medical_specialty, Time Factors, Placebo, Gastroenterology, Article, Preeclampsia, Proinflammatory cytokine, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Internal medicine, Blood plasma, medicine, Humans, Receptors, Tumor Necrosis Factor, Type II, reproductive and urinary physiology, Aspirin, business.industry, Obstetrics and Gynecology, medicine.disease, female genital diseases and pregnancy complications, Endocrinology, Quartile, Gestation, Female, business, medicine.drug
Abstract

Objective Soluble receptor levels of tumor necrosis factor (sTNF-R)-1 and -2 are increased during preeclampsia. We postulated the increase preceded overt disease. Study Design Archived plasma from the Eunice Kennedy Shriver National Institute of Child Health and Human Development aspirin to prevent preeclampsia in high risk women trial were used to measure serial sTNF-R1 and sTNF-R2 (enrollment, 24-28 week's gestation) in 986 women (577 also sampled at 34-38 weeks). Results Preeclampsia incidence was 21.2%. sTNF-R2 levels were higher at enrollment ( P = .02) and weeks 24-28 ( P = .01) in women who eventually developed preeclampsia. The magnitude of increase from baseline of both receptors was significantly greater in women who developed preeclampsia in the future. Women with week 24-28 sTNF-R2 levels in the highest quartile had significantly increased odds to develop preeclampsia ( P = .03 vs quartile 1). This association was observed in the placebo but not the aspirin arm ( P ≤ .002). Sensitivities and positive predictive values were low. Conclusion sTNF-R2 levels are elevated prior to overt preeclampsia, suggesting a pathogenetic role for these proinflammatory cytokines.

Published
2009

9. 'The Killing Fields'

Author

Hauth, John

Subjects
Fire engines -- Inspection -- Maintenance and repair -- Services, Fire-departments -- Services -- Inspection, Law
Abstract

I read with interest Michael Wilbur's Emergency Vehicle Operations column, 'The Killing Fields,' and the reader responses in the November issue of Firehouse®. I have been a volunteer firefighter for [...]

Published
2008

10. Requiring Professional Athletic Training Programs at the Post-Baccalaureate Level: Considerations and Concerns... includes commentary by Henning, J., and Hauth, J.

Author

Pitney, William A., Henning, Jolene, and Hauth, John M.

Subjects
ATHLETIC trainers, CLINICAL competence, HEALTH occupations students, MEDICAL care, TRAINING of athletic trainers, PROFESSIONAL practice, JOB performance, HEALTH occupations school faculty, MASTERS programs (Higher education)
Abstract

The author reflects on moving the athletic training programs to the professional programs at the post-baccalaureate level. He informs that there are many positive aspects of moving to the Entry-Level Masters (ELM) programs including improved professional preparation of the students, selection more qualified students and alignment of the professional programs with peer health care.

Published
2012
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11. Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies.

Author

Powers, Robert W., Jeyabalan, Arun, Clifton, Rebecca G., Van Dorsten, Peter, Hauth, John C., Klebanoff, Mark A., Lindheimer, Marshall D., Sibai, Baha, Landon, Mark, and Miodovnik, Menachem

Subjects
HIGH-risk pregnancy, PREECLAMPSIA, PREGNANT women, PLACENTA, PROTEIN-tyrosine kinases, VASCULAR endothelial growth factors, PSYCHOLOGY
Abstract

Background: Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women. The objective of this study was to investigate whether similar changes can be detected in pregnant women at highrisk to develop the syndrome. Methods: This study is a secondary analysis of the NICHD MFMU trial of aspirin to prevent preeclampsia in high-risk pregnancies. Serum samples were available from 194 women with pre-existing diabetes, 313 with chronic hypertension, 234 with multifetal gestation, and 252 with a history of preeclampsia in a previous pregnancy. Samples collected across pregnancy were analyzed in a blinded fashion for sFlt1, sEng and PlGF. Results: The odds of developing preeclampsia were significantly increased among women with multiple fetuses for each 2- fold elevation in sFlt1, sEng and the ratio of angiogenic factors (e.g. OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation. Cross-sectional analysis of the angiogenic factors across gestation showed significant differences during the third trimester in women who develop preeclampsia compared with appropriate controls in all high-risk groups. However, when data were examined in relation to the gestational week when preeclampsia was diagnosed only sFlt1 was significantly higher 2 to 5 weeks before the clinical onset of preeclampsia and only in women with previous preeclampsia. Conclusions: The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women. However, differences in these factors among high-risk women who do and do not develop preeclampsia are modest, and do not appear to be clinically useful predictors in these high-risk pregnant women. [ABSTRACT FROM AUTHOR]

Published
2010
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12. Effect of Smoking on Circulating Angiogenic Factors in High Risk Pregnancies.

Author

Jeyabalan, Arun, Powers, Robert W., Clifton, Rebecca G., Van Dorsten, Peter, Hauth, John C., Klebanoff, Mark A., Lindheimer, Marshall D., Sibai, Baha, Landon, Mark, and Miodovnik, Menachem

Subjects
HIGH-risk pregnancy, PHYSIOLOGICAL effects of tobacco, VASCULAR endothelial growth factors, PREGNANT women, WOMEN'S tobacco use, PREECLAMPSIA prevention
Abstract

Objective: Changes in maternal concentrations of the anti-angiogenic factors, soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng), and the pro-angiogenic placental growth factor (PlGF) precede the development of preeclampsia in healthy women. The risk of preeclampsia is reduced in women who smoke during pregnancy. The objective of this study was to investigate whether smoking affects concentrations of angiogenic factors (sFlt1, PlGF, and sEng) in women at high risk for developing preeclampsia. Study Design: We performed a secondary analysis of serum samples from 993 high-risk women (chronic hypertension, diabetes, multifetal gestation, and previous preeclampsia) in a preeclampsia prevention trial. sFlt1, sEng and PlGF were measured in serum samples obtained at study entry, which was prior to initiation of aspirin (median 19.0 weeks' [interquartile range of 16.0-22.6 weeks']). Smoking status was determined by self-report. Results: sFlt1 was not significantly different in smokers from any high-risk groups compared to their nonsmoking counterparts. PlGF was higher among smokers compared to nonsmokers among diabetic women (142.7 [77.4-337.3] vs 95.9 [48.5-180.7] pg/ml, p = 0.005) and women with a history of preeclampsia (252.2 [137.1-486.0] vs 152.2 [73.6-253.7] pg/ml, p = 0.001). sEng was lower in smokers with multifetal gestations (5.8 [4.6-6.5] vs 6.8 [5.5-8.7] ng/ml, p = 0.002) and trended lower among smokers with diabetes (4.9 [3.8-5.6] vs 5.3 [4.3-6.3] ng/ml, p = 0.05). Smoking was not associated with a lower incidence of preeclampsia in any of these groups. Conclusions: In certain high-risk groups, smoking is associated with changes in the concentrations of these factors towards a pro-angiogenic direction during early pregnancy; however, there was no apparent association between smoking and the development of preeclampsia in our cohort. [ABSTRACT FROM AUTHOR]

Published
2010
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13. Apolipoprotein A1 in Umbilical Cord Blood of Newborn Infants

Author

PARKER, C. RICHARD, FORTUNATO, STEPHEN J., CARR, BRUCE R., OWEN, JOHN, HANKINS, GARY D. V., and HAUTH, JOHN C.

Abstract

Apolipoprotein A-1 (Apo A-1) is the major protein constituent of high-density lipoprotein (HDL) and Apo A-1 plays an important role in lipid metabolism and may be protective against atherosclerosis in adults. However, little is known about HDL and Apo A-1 in the developing human fetus. Herein we investigated the relationship of Apo A-1 levels in umbilical cord blood at delivery to gestational age and HDL cholesterol. Fetal plasma levels of Apo A-1, which were not correlated with those in maternal plasma, were significantly lower among newborns delivered at 21–26 wk gestation (52 ± 4.4 mg/ dl, mean ± SE) than in those delivered at 33–34 wk gestation (87 ± 5.8 mg/dl). Thereafter, the mean umbilical cord plasma levels of Apo A-1 remained relatively constant (101 mg/dl at 39–40 wk of gestation). We found no significant correlations between Apo A-1 levels and fetal sex, race, or delivery method. At equivalent gestational ages and birth weights, however, Apo A-1 levels in white newborns tended to be lower than those in black infants. The Apo A-1/HDL cholesterol ratio in umbilical cord blood rose progressively from 2.5 (27–28 wk gestation) to 3.8 at term, due largely to increased Apo A-l levels but little change in the mean HDL cholesterol levels, which ranged from 22–24 mg/dl at each gestational period. These results are suggestive that fetal plasma Apo A-1 is derived solely from fetal sources and that the rate of production and/or clearance of Apo A-1 is altered during the latter third of human intrauterine development.

Published
1988

14. Apolipoprotein A-1 in Umbilical Cord Blood of Newborn Infants: Relation to Gestational Age and High-Density Lipoprotein Cholesterol

Author

Richard Parker, C, Fortunato, Stephen J, Carr, Bruce R, Owen, John, Hankins, Gary D V, and Hauth, John C

Abstract

ABSTRACT: Apolipoprotein A-1 (Apo A-1) is the major protein constituent of high-density lipoprotein (HDL) and Apo A-1 plays an important role in lipid metabolism and may be protective against atherosclerosis in adults. However, little is known about HDL and Apo A-1 in the developing human fetus. Herein we investigated the relationship of Apo A-1 levels in umbilical cord blood at delivery to gestational age and HDL cholesterol. Fetal plasma levels of Apo A-1, which were not correlated with those in maternal plasma, were significantly lower among newborns delivered at 21–26 wk gestation (52 ± 4.4 mg/dl, mean ± SE) than in those delivered at 33–34 wk gestation (87 ± 5.8 mg/dl). Thereafter, the mean umbilical cord plasma levels of Apo A-1 remained relatively constant (101 mg/dl at 39–40 wk of gestation). We found no significant correlations between Apo A-1 levels and fetal sex, race, or delivery method. At equivalent gestational ages and birth weights, however, Apo A-1 levels in white newborns tended to be lower than those in black infants. The Apo A-1/HDL cholesterol ratio in umbilical cord blood rose progressively from 2.5 (27–28 wk gestation) to 3.8 at term, due largely to increased Apo A-l levels but little change in the mean HDL cholesterol levels, which ranged from 22–24 mg/dl at each gestational period. These results are suggestive that fetal plasma Apo A-1 is derived solely from fetal sources and that the rate of production and/or clearance of Apo A-1 is altered during the latter third of human intrauterine development.

Published
1988
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15. FORUM.

Author

Hauth, John, Fennelly, Keith E., and Kueppers, Klaus

Subjects
LETTERS to the editor, EMERGENCY vehicles, VOLUNTEER fire fighters, FIREFIGHTING, FIRE prevention
Abstract

Several letters to the editor are presented in response to articles in previous issues including "The Killing Fields," by Michael Wilbur, "Defensive Operations — Part 1," in the November 2007 issue and "Guest Commentary: What Lessons Have We Learned?," by Captain Tony Tricarico in the November 2007 issue.

Published
2008

16. Fireground Setup Time.

Author

Grace, Patrick T. and Hauth, John

Subjects
FIRE prevention, FIREFIGHTING, FIRE fighters, SERIAL publications
Abstract

Several letters to the editor are presented in response to the article "Fireground Setup Time, Measured Scientifically: Research Fills a Gap in Knowledge of Firefighting Tasks" by Vincent Dunn in March 2013 issue of Firehouse Magazine.

Published
2013

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