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937 results on '"Hashimoto R"'

1. Successful Fistula Closure After Treatment with Colostomy and Infliximab in a Patient with Ulcerative Colitis Complicated by Rectovaginal Fistula

Author: Katsube S, Matsumoto S, Misawa M, Kakizawa N, Hashimoto R, Mizutani T, Matsumoto K, Yoshikawa S, and Mashima H
Subjects: ulcerative colitis, rectovaginal fistula, infliximab, colostomy, Medicine (General), R5-920
Abstract: Sota Katsube,1 Satohiro Matsumoto,1 Masahiro Misawa,2 Nao Kakizawa,3 Ryo Hashimoto,1 Taku Mizutani,1 Keita Matsumoto,1 Shuhei Yoshikawa,1 Hirosato Mashima1 1Department of Gastroenterology, Jichi Medical University Saitama Medical Center, Saitama, Japan; 2Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, Saitama, Japan; 3Department of General and Gastrointestinal Surgery, Jichi Medical University Saitama Medical Center, Saitama, JapanCorrespondence: Sota Katsube, Department of Gastroenterology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma, Saitama, Omiya, 330-8503, Japan, Tel +81 48 647 2111, Fax +81 48 648 5188, Email m08029sk@jichi.ac.jpAbstract: The patient was a 50-year-old Japanese woman who was diagnosed with total-colitis-type ulcerative colitis (UC) at the age of 26 years. She was treated with mesalazine and azathioprine, and her disease activity was well controlled. At the age of 50 years, the patient was experiencing fever, abdominal pain, diarrhea, bloody stool, and anal pain, which led to a diagnosis of a relapse of UC. Although steroid therapy was administered and tended to improve her symptoms, fecaloid vaginal discharge occurred, and rectovaginal fistula (RVF) was confirmed. Colostomy was performed, and infliximab was initiated as maintenance therapy for UC. All symptoms improved, and RVF closure was confirmed 6 months after the initiation of infliximab. To date, she has been free from relapse of UC. There have been only a few reports of UC complicated by RVF, and this condition is often difficult to treat. To the best of our knowledge, no other case of UC complicated by RVF in which the fistula was closed after treatment with colostomy and infliximab has been previously reported; thus, our report of the present case is valuable to the literature.Keywords: ulcerative colitis, rectovaginal fistula, infliximab, colostomy
Published: 2024

2. Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy

Author: Sakamoto M, Hashimoto R, Yoshida I, Ubuka M, and Maeno T
Subjects: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy, Ophthalmology, RE1-994
Abstract: Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Ocular parameters examined included preoperative best-corrected visual acuity, preoperative IOP, operative history (specifically panretinal photocoagulation), lens status, ocular pathology (eg, iris/angle neovascularization, tractional retinal detachment, diabetic macular edema, vitreous hemorrhage, combined tractional retinal detachment), intraoperative retinal tamponade use, vitrectomy gauge, combined lens extraction/vitrectomy procedure, subsequent surgical procedures, and pre- and postoperative intravitreal bevacizumab. Correlations between variables and postoperative NVG development were examined using logistic regression analyses (backward elimination method).Results: A total of 254 eyes of 196 consecutive subjects (146 men [74.5%], 54.0±10.8 years old) were included. Sixty of 254 eyes (23.6%) developed NVG. Several preoperative factors increased the risk of developing NVG, including iris/angle neovascularization (P=0.042), preoperative high IOP (P=0.005), low HbA1c (P=0.004), and administration of insulin (P=0.045). Intraoperative retinal tamponade also increased NVG risk (P=0.021, backward elimination method).Conclusion: Preoperative parameters such as elevated IOP, iris/angle neovascularization, fasting blood sugar and HbA1c discrepancies, administration of insulin, as well as use of retinal tamponade during retinal surgery were identified as the risk factors for developing NVG. Keywords: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy
Published: 2018

3. Risk factors for retinal breaks during macular hole surgery

Author: Sakamoto M, Yoshida I, Hashimoto R, Masahara H, and Maeno T
Subjects: macular hole, iatrogenic retinal breaks, vitrectomy, lattice degeneration, Ophthalmology, RE1-994
Abstract: Masashi Sakamoto, Izumi Yoshida, Ryuya Hashimoto, Hidetaka Masahara, Takatoshi Maeno Department of Ophthalmology, Toho University Sakura Medical Center, Sakura, Japan Purpose: To identify risk factors for retinal breaks during macular hole (MH) surgery.Patients and methods: This retrospective, observational, comparative study included the medical records of 364 consecutive patients (382 eyes) who underwent vitrectomy for MH at Toho University Sakura Medical Center between January 2012 and May 2017. The patients comprised 135 men and 229 women with mean age 67.6±8.0 years. Six eyes with a pre-existing retinal tear treated by laser photocoagulation before MH surgery were excluded. Data on sex, age, presence or absence of lattice degeneration, axial length (measured using an IOL Master®), preoperative refraction, whether or not combined lens extraction/vitrectomy had been performed, whether or not the lens was pseudophakic before vitrectomy, and whether or not a posterior vitreous detachment had been created intraoperatively were collected. The lattice degeneration status was classified as none (0), treated using laser photocoagulation (1), or untreated (2).Results: The only item identified in logistic regression analysis with the backward elimination method to be a significant risk factor for retinal breaks during MH surgery was the presence of lattice degeneration (P
Published: 2018

4. Risk factors for requirement of filtration surgery after vitrectomy in patients with proliferative diabetic retinopathy

Author: Sakamoto M, Hashimoto R, Yoshida I, and Maeno T
Subjects: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy, gas tamponade, Ophthalmology, RE1-994
Abstract: Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Takatoshi Maeno Department of Ophthalmology, Sakura Medical Center of Toho University, Shimoshizu, Sakura, Japan Purpose: We retrospectively reviewed patients with postoperative neovascular glaucoma (NVG) after vitrectomy for proliferative diabetic retinopathy to investigate how variables assessed before, during, and after vitrectomy are associated with the requirement for filtration surgery. Patients and methods: The subjects in this retrospective, observational, comparative study were 55 consecutive patients (61 eyes) who underwent vitrectomy for proliferative diabetic retinopathy at Toho University Sakura Medical Center between December 2011 and November 2016, were followed up for at least 6 months after surgery, and developed NVG within 2 years after surgery. They comprised 44 men and 11 women of mean age 52.4±9.1 years, who were followed up for a mean 7.1±6.1 months. We collected data on the following 16 variables: sex, age, history of panretinal photocoagulation completed within 3 months before vitrectomy, presence/absence of a lens, obvious iris/angle neovascularization, tractional retinal detachment, diabetic macular edema, vitreous hemorrhage, visual acuity and intraocular pressure before vitrectomy and at the onset of NVG, glycated hemoglobin, fasting blood glucose, estimated glomerular filtration rate, and use of intraoperative gas tamponade. Results: Logistic regression analysis with the backward elimination method identified preoperative fasting hyperglycemia (P=0.08), high intraocular pressure at the onset of NVG (P=0.04), and use of gas tamponade during vitrectomy (P=0.008) to be significant risk factors for requirement of filtration surgery. Conclusion: Preoperative fasting hyperglycemia, high intraocular pressure at the onset of NVG, and use of gas tamponade during vitrectomy predispose patients to require filtration surgery in the event of postoperative NVG. Keywords: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy, gas tamponade
Published: 2018

5. Coherent photoproduction of the neutral pion and eta meson on the deuteron at incident energies below 1.15 GeV

Author: Ishikawa, T., Fix, A., Fujimura, H., Fukasawa, H., Hashimoto, R., He, Q., Honda, Y., Iwata, T., Kaida, S., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nawa, K., Obara, Y., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Takahashi, S., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment, High Energy Physics - Experiment, Nuclear Theory
Abstract: Coherent photoproduction of the neutral pion and eta meson on the deuteron, $\gamma{d}${$\to$}$\pi^0\eta{d}$, has been experimentally studied at incident photon energies ranging from the reaction threshold to 1.15 GeV. The total cross section demonstrates a rapid rise below 1 GeV. The data are underestimated by the existing theoretical calculations based on quasi-free $\pi^0 \eta$ photoproduction on the nucleon followed by deuteron coalescence. At the same time, the data are rather well reproduced by the calculations taking into account the final-state interaction. We have also measured for the first time the differential cross sections: the $\pi^0 \eta$ invariant-mass distribution $d\sigma/dM_{\pi \eta}$, the $\pi^0 d$ invariant-mass distribution $d\sigma/dM_{\pi d}$, the $\eta d$ invariant-mass distribution $d\sigma/dM_{\eta d}$, and the distribution over the deuteron emission angle $d\sigma/d\Omega_d$ in the overall center-of-mass frame. The measured cross section $d\sigma/d\Omega_d$ does not exhibit strongly backward-peaking behavior predicted by the calculations. At all incident energies, an increase in $d\sigma/dM_{\eta d}$ near the $\eta d$ threshold is observed, which indicates a bound or virtual $\eta d$ state resulting from a strong attraction between $\eta$ and a deuteron. The possibilities of using coherent $\pi^0\eta$ photoproduction on a nucleus to study the $\eta$-nuclear interaction are also discussed., Comment: 15 pages, 9 figures
Published: 2022
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6. Double neutral pion photoproduction off the proton with FOREST at ELPH

Author: He Q., Fujimura H., Fukasawa H., Hashimoto R., Honda Y., Ishikawa T., Iwata T., Kaida S., Kasagi J., Kawano A., Kuwasaki S., Maeda K., Masumoto S., Miyabe M., Miyahara F., Mochizuki K., Muramatsu N., Nakamura A., Nawa K., Ogushi S., Okada Y., Onodera Y., Ozawa K., Sakamoto Y., Sato M., Shimizu H., Sugai H., Suzuki K., Tajima Y., Takahashi S., Taniguchi Y., Tsuchikawa Y., Yamazaki H., Yamazaki R., and Yoshida H. Y.
Subjects: Physics, QC1-999
Abstract: Total cross section for the double neutral pion photoproduction off the proton is presented in the incident photon energy range of 0.58 to 1.15 GeV. The data were accumulated in the years 2009–2010, recorded by a 4π EM calorimeter at ELPH, named FOREST. The number of recorded events obtained during this period is 1.6×109 for a hydrogen target. Two neutral pions are reconstructed via detecting their decay products, four gammas (2π0 → 4γ). Compared to the previous results obtained by other groups, our data are in good agreement with theirs within error bars.
Published: 2016
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7. Resonance-like structure near the $\eta d$ threshold in the $\gamma{d}${$\to$}$\pi^0\eta{d}$ reaction

Author: Ishikawa, T., Fujimura, H., Fukasawa, H., Hashimoto, R., He, Q., Honda, Y., Iwata, T., Kaida, S., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nawa, K., Obara, Y., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Takahashi, S., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment
Abstract: To investigate the interaction between the nucleon $N$ and nucleon resonance $N(1535)1/2^-$, the $\eta d$ threshold structure connected to the isoscalar $S$-wave $N$-$N(1535)1/2^-$ system has been experimentally studied in the $\gamma{d}${$\to$}$\pi^0\eta{d}$ reaction at incident photon energies ranging from the reaction threshold to 1.15 GeV. A strong enhancement is observed near the $\eta d$ threshold over the three-body phase-space contribution in the $\eta d$ invariant-mass distribution. An analysis incorporating the known isovector resonance $\mathcal{D}_{12}$ with a spin-parity of $2^+$ in the $\pi^0d$ channel reveals the existence of a narrow isoscalar resonance-like structure with $1^-$ in the $\eta d$ system. Using a Flatt\'e parametrization, the mass is found to be $2.427_{-0.006}^{+0.013}$ GeV, close to the $\eta d$ threshold, and the width is $\left(0.029_{-0.029}^{+0.006}{\rm\ GeV}\right)+\left(0.00_{-0.00}^{+0.41}\right) p_\eta c$, where $p_\eta$ denotes the $\eta$ momentum in the rest frame of the $\eta d$ system. The observed structure would be attributed to a predicted isoscalar $1^-$ $\eta NN$ bound state from $\eta NN$ and $\pi NN$ coupled-channel calculation, or an $\eta d$ virtual state owing to strong $\eta d$ attraction., Comment: 6 pages, 3 figures
Published: 2021
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8. $\omega N$ scattering length from $\omega$ photoproduction on the proton near the threshold

Author: Ishikawa, T., Fujimura, H., Fukasawa, H., Hashimoto, R., He, Q., Honda, Y., Hosaka, A., Iwata, T., Kaida, S., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nakamura, S. X., Nawa, K., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Sato, T., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Takahashi, S., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment
Abstract: Photoproduction of the $\omega$ meson on the proton has been experimentally studied near the threshold. The total cross sections are determined at incident energies ranging from 1.09 to 1.15 GeV. The 1/2 and 3/2 spin-averaged scattering length $a_{\omega p}$ and effective range $r_{\omega p}$ between the $\omega$ meson and proton are estimated from the shape of the total cross section as a function of the incident photon energy: $a_{\omega p} = \left(-0.97^{+0.16_{\rm stat}}_{-0.16_{\rm stat}}{}^{+0.03_{\rm syst}}_{-0.00_{\rm syst}}\right)+i \left(0.07^{+0.15_{\rm stat}}_{-0.14_{\rm stat}}{}^{+0.17_{\rm syst}}_{-0.09_{\rm syst}}\right)$ fm and $r_{\omega p}=\left(+2.78^{+0.68_{\rm stat}}_{-0.54_{\rm stat}}{}^{+0.11_{\rm syst}}_{-0.13_{\rm syst}}\right)+i\left(-0.01^{+0.46_{\rm stat}}_{-0.50_{\rm stat}}{}^{+0.07_{\rm syst}}_{-0.00_{\rm syst}}\right)$ fm, resulting in a repulsive force. The real and imaginary parts for $a_{\omega p}$ and $r_{\omega p}$ are determined separately for the first time. A small $P$-wave contribution does not affect the obtained values., Comment: 6 pages, 4 figures
Published: 2019
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9. Non-strange Dibaryon Resonances Observed in the $\gamma d\to \pi^0\pi^0 d$ Reaction

Author: Ishikawa, T., Fujimura, H., Fukasawa, H., Hashimoto, R., He, Q., Honda, Y., Iwata, T., Kaida, S., Kanda, H., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nawa, K., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Takahashi, S., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: Coherent double neutral-pion photoproduction on the deuteron, $\gamma{d}${$\to$}$\pi^0\pi^0{d}$, has been experimentally studied at incident photon energies ranging from 0.75 to 1.15 GeV. The total cross section as a function of the $\gamma{d}$ center-of-mass energy shows resonance-like behavior, which peaks at approximately 2.47 and 2.63 GeV. The measured angular distribution of deuteron emission is rather flat, which cannot be reproduced by the kinematics of quasi-free $\pi^0\pi^0$ production with deuteron coalescence. In $\pi^0d $ invariant-mass distributions, a clear peak is observed at $2.14{\pm}0.01$ GeV$/c^2$ with a width of $0.09{\pm}0.01$ GeV$/c^2$. The spin-parity of this state is restricted to $1^+$, $2^+$ or $3^-$ from the angular distributions of the two $\pi^0$s. The present work shows strong evidence for the existence of an isovector dibaryon resonance with a mass of 2.14 GeV$/c^2$. The $2^+$ assignment is consistent with the theoretically predicted ${\cal{D}}_{12}$ state, and also with the energy dependence of the $\pi{d}$ partial-wave amplitude $^3\!P_2$ for the $\pi^{\pm}d${$\to$}$\pi^{\pm}d$ and $\pi^+d${$\to$}${pp}$ reactions., Comment: 12 pages, 6 figures
Published: 2018
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10. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author: Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, OA, Arango, C, Banaj, N, Bouix, S, Bousman, CA, Brouwer, RM, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, J-X, Chen, X, Chiapponi, C, Cho, Kl K, Ciullo, V, Corvin, AS, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, CM, Dickie, EW, Ehrlich, S, Fan, F-M, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, JM, Fouche, J-P, Fukunaga, M, Gill, M, Glahn, DC, Gollub, R, Goudzwaard, ED, Guo, H, Gur, RE, Gur, RC, Gurholt, TP, Hashimoto, R, Hatton, SN, Henskens, FA, Hibar, DP, Hickie, IB, Hong, LE, Horacek, J, Howells, FM, Hulshoff Pol, HE, Hyde, CL, Isaev, D, Jablensky, A, Jansen, PR, Janssen, J, Jönsson, EG, Jung, LA, Kahn, RS, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, RK, Lim, KO, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, RCW, Mathalon, DH, McCarley, RW, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, RI, Michie, PT, Mowry, B, Mueller, BA, Newell, DT, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, SA, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, GR, Pereira, A, and Pineda Zapata, J
Subjects: Neurosciences, Brain Disorders, Mental Health, Serious Mental Illness, Biomedical Imaging, Schizophrenia, Clinical Research, Mental health, Adult, Aged, Aged, 80 and over, Brain, Cohort Studies, Corpus Callosum, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, White Matter, Young Adult, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
Published: 2018

11. Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.

Author: Walton, E, Hibar, DP, van Erp, TGM, Potkin, SG, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, van Haren, NEM, de Zwarte, SMC, Kahn, RS, Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Morch-Johnsen, L, Færden, A, Flyckt, L, Fatouros-Bergman, H, Karolinska Schizophrenia Project Consortium (KaSP), Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Jahanshad, N, De Rossi, P, Piras, F, Banaj, N, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, DM, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, HC, Neilson, E, Calhoun, VD, Thompson, PM, Turner, JA, and Ehrlich, S
Subjects: Karolinska Schizophrenia Project Consortium, Prefrontal Cortex, Humans, Magnetic Resonance Imaging, Linear Models, Schizophrenia, Psychiatric Status Rating Scales, Schizophrenic Psychology, Internationality, Image Processing, Computer-Assisted, Adult, Female, Male, Functional Laterality, Cortical thickness, ENIGMA, FreeSurfer, MRI, PANSS, SANS, medial orbitofrontal cortex, negative symptoms, schizophrenia, Image Processing, Computer-Assisted, Psychiatry, Psychology, Public Health and Health Services, Neurosciences
Abstract: BackgroundOur understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.MethodsThis study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores).ResultsMeta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = -0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.ConclusionsUsing an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.
Published: 2018

12. First measurement of coherent double neutral-pion photoproduction on the deuteron at incident energies below 0.9 GeV

Author: Ishikawa, T., Fujimura, H., Fukasawa, H., Hashimoto, R., He, Q., Honda, Y., Iwata, T., Kaida, S., Kanda, H., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nawa, K., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment
Abstract: The total cross sections were measured for coherent double neutral-pion photoproduction on the deuteron at incident energies below 0.9 GeV for the first time. No clear resonance-like behavior is observed in the excitation function for $W_{\gamma d}=2.38$--2.61 GeV, where the $d^*(2380)$ dibaryon resonance observed at COSY is expected to appear. The measured excitation function is consistent with the existing theoretical calculation for this reaction. The upper limit of the total cross section is found to be $0.034$~$\mu$b for the dibaryon resonance at $W_{\gamma d}=2.37$~GeV (90\% confidence level) in the $\gamma d \to \pi^0\pi^0 d$ reaction., Comment: submitted to Physics Letters B
Published: 2016
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13. Exclusive $\omega$ meson muoproduction on transversely polarised protons

Author: Adolph, C., Agarwala, J., Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chung, S. -U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmueller, S., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Heitz, R., Herrmann, F., Hinterberger, F., Horikawa, N., dHose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Michigami, T., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Roskot, M., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Seder, E., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Sozzi, F., Srnka, A., Steffen, D., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tasevsky, M., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Vondra, J., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: Exclusive production of $\omega$ mesons was studied at the COMPASS experiment by scattering $160~\mathrm{GeV}/\mathit{c}$ muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured in the range of photon virtuality $1~(\mathrm{GeV}/\mathit{c})^2 < Q^2 < 10~(\mathrm{GeV}/\mathit{c})^2$, Bjorken scaling variable $0.003 < x_{\mathit{Bj}} < 0.3$ and transverse momentum squared of the $\omega$ meson $0.05~(\mathrm{GeV}/\mathit{c})^2 < p_{T}^{2} < 0.5~(\mathrm{GeV}/\mathit{c})^2$. The measured asymmetries are sensitive to the nucleon helicity-flip Generalised Parton Distributions (GPD) $E$ that are related to the orbital angular momentum of quarks, the chiral-odd GPDs $H_{T}$ that are related to the transversity Parton Distribution Functions, and the sign of the $\pi\omega$ transition form factor. The results are compared to recent calculations of a GPD-based model., Comment: 23 pages, 9 figures
Published: 2016
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14. Multiplicities of charged pions and unidentified charged hadrons from deep-inelastic scattering of muons off an isoscalar target

Author: Adolph, C., Agarwala, J., Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Capozza, L., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chung, S. -U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmueller, S., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Heitz, R., Herrmann, F., Hinterberger, F., Horikawa, N., dHose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kuhn, R., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, W., Michigami, T., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Roskot, M., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Seder, E., Selyunin, A., Shevchenko, O. Yu., Steffen, D., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tasevsky, M., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Vondra, J., Weisrock, T., Wilfert, M., Windmolders, R., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: Multiplicities of charged pions and unidentified hadrons produced in deep-inelastic scattering were measured in bins of the Bjorken scaling variable $x$, the relative virtual-photon energy $y$ and the relative hadron energy $z$. Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam and an isoscalar target ($^6$LiD). They cover the kinematic domain in the photon virtuality $Q^2$ > 1(GeV/c$)^2$, $0.004 < x < 0.4$, $0.2 < z < 0.85$ and $0.1 < y < 0.7$. In addition, a leading-order pQCD analysis was performed using the pion multiplicity results to extract quark fragmentation functions.
Published: 2016
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15. An event mixing technique for Bose-Einstein correlations of two pions in photoproduction around 1 GeV

Author: He, Qing-Hua, Fujimura, H., Fukasawa, H., Hashimoto, R., Honda, Y., Ishikawa, T., Iwata, T., Kaida, S., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Masumoto, S., Miyabe, M., Miyahara, F., Mochizuki, K., Muramatsu, N., Nakamura, A., Nawa, K., Ogushi, S., Okada, Y., Onodera, Y., Ozawa, K., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Tajima, Y., Takahashi, S., Taniguchi, Y., Tsuchikawa, Y., Yamazaki, H., Yamazaki, R., and Yoshida, H. Y.
Subjects: Nuclear Experiment
Abstract: We have developed an event mixing technique to observe Bose-Einstein correlations (BEC) between two identical neutral pions produced in photo-induced reactions in the non-perturbative QCD energy region. It is found that the missing-mass consistency cut and the pion-energy cut are essential for the event mixing method to effectively extract BEC observables. A Monte Carlo (MC) simulation is used to validate these constraints and confirms the efficiency of this method. Our work paves the way for similar BEC studies at lower energies where the multiplicity of emitted bosons is limited.
Published: 2016
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16. Leading-order determination of the gluon polarisation from semi-inclusive deep inelastic scattering data

Author: Adolph, C., Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. -U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmueller, S., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Heitz, R., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, W., Michigami, T., Mikhailov, Yu. V., Mikhasenko, M., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Roskot, M., Rossiyskaya, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Seder, E., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tasevsky, M., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Vondra, J., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: Using a novel analysis technique, the gluon polarisation in the nucleon is re-evaluated using the longitudinal double-spin asymmetry measured in the cross section of semi-inclusive single-hadron muoproduction with photon virtuality $Q^2>1~({\rm GeV}/c)^2$. The data were obtained by the COMPASS experiment at CERN using a 160 GeV/$c$ polarised muon beam impinging on a polarised $^6$LiD target. By analysing the full range in hadron transverse momentum $p_{\rm T}$, the different $p_{\rm T}$-dependences of the underlying processes are separated using a neural-network approach. In the absence of pQCD calculations at next-to-leading order in the selected kinematic domain, the gluon polarisation $\Delta g/g$ is evaluated at leading order in pQCD at a hard scale of $\mu^2= \langle Q^2 \rangle = 3 ({\rm GeV}/c)^2$. It is determined in three intervals of the nucleon momentum fraction carried by gluons, $x_{\rm g}$, covering the range $0.04 \!<\! x_{ \rm g}\! <\! 0.28$~ and does not exhibit a significant dependence on $x_{\rm g}$. The average over the three intervals, $\langle \Delta g/g \rangle = 0.113 \pm 0.038_{\rm (stat.)}\pm 0.036_{\rm (syst.)}$ at $\langle x_{\rm g} \rangle \approx 0.10$, suggests that the gluon polarisation is positive in the measured $x_{\rm g}$ range., Comment: 14 pages, 6 figures
Published: 2015

17. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

Author: Walton, E, Hibar, DP, Erp, TGM, Potkin, SG, Roiz‐Santiañez, R, Crespo‐Facorro, B, Suarez‐Pinilla, P, Van Haren, NEM, Zwarte, SMC, Kahn, RS, Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Mørch‐Johnsen, L, Færden, A, Flyckt, L, Fatouros‐Bergman, H, Consortium, Karolinska Schizophrenia Project, Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Preda, A, De Rossi, P, Piras, F, Banaj, N, Ciullo, V, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, DM, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, HC, Neilson, E, Calhoun, VD, Thompson, PM, Turner, JA, and Ehrlich, S
Subjects: Schizophrenia, Mental Health, Brain Disorders, Mental health, Good Health and Well Being, Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Psychiatric Status Rating Scales, Schizophrenic Psychology, Temporal Lobe, schizophrenia, positive symptoms, superior temporal gyrus, cortical thickness, ENIGMA, FreeSurfer, MRI, scale for the assessment of positive symptoms, positive and negative syndrome scale, Karolinska Schizophrenia Project Consortium, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: ObjectiveBased on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.MethodThis prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.ResultsPositive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.ConclusionOur findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
Published: 2017

18. Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers

Author: Boen, R, Kaufmann, T, van der Meer, D, Frei, O, Agartz, I, Ames, D, Andersson, M, Armstrong, NJ, Artiges, E, Atkins, JR, Bauer, J, Benedetti, F, Boomsma, DI, Brodaty, H, Brosch, K, Buckner, RL, Cairns, MJ, Calhoun, V, Caspers, S, Cichon, S, Corvin, AP, Crespo-Facorro, B, Dannlowski, U, David, FS, de Geus, EJC, de Zubicaray, GI, Desrivieres, S, Doherty, JL, Donohoe, G, Ehrlich, S, Eising, E, Espeseth, T, Fisher, SE, Forstner, AJ, Fortaner-Uya, L, Frouin, V, Fukunaga, M, Ge, T, Glahn, DC, Goltermann, J, Grabe, HJ, Green, MJ, Groenewold, NA, Grotegerd, D, Grontvedt, GR, Hahn, T, Hashimoto, R, Hehir-Kwa, JY, Henskens, FA, Holmes, AJ, Haberg, AK, Haavik, J, Jacquemont, S, Jansen, A, Jockwitz, C, Joensson, EG, Kikuchi, M, Kircher, T, Kumar, K, Le Hellard, S, Leu, C, Linden, DE, Liu, J, Loughnan, R, Mather, KA, Mcmahon, KL, Mcrae, AF, Medland, SE, Meinert, S, Moreau, CA, Morris, DW, Mowry, BJ, Muehleisen, TW, Nenadic, I, Noethen, MM, Nyberg, L, Ophoff, RA, Owen, MJ, Pantelis, C, Paolini, M, Paus, T, Pausova, Z, Persson, K, Quide, Y, Marques, TR, Sachdev, PS, Sando, SB, Schall, U, Scott, RJ, Selbaek, G, Shumskaya, E, Silva, AI, Sisodiya, SM, Stein, F, Stein, DJ, Straube, B, Streit, F, Strike, LT, Teumer, A, Teutenberg, L, Thalamuthu, A, Tooney, PA, Tordesillas-Gutierrez, D, Trollor, JN, Van't Ent, D, van den Bree, MBM, van Haren, NEM, Vazquez-Bourgon, J, Voelzke, H, Wen, W, Wittfeld, K, Ching, CRK, Westlye, LT, Thompson, PM, Bearden, CE, Selmer, KK, Alnaes, D, Andreassen, OA, Sonderby, IE, Boen, R, Kaufmann, T, van der Meer, D, Frei, O, Agartz, I, Ames, D, Andersson, M, Armstrong, NJ, Artiges, E, Atkins, JR, Bauer, J, Benedetti, F, Boomsma, DI, Brodaty, H, Brosch, K, Buckner, RL, Cairns, MJ, Calhoun, V, Caspers, S, Cichon, S, Corvin, AP, Crespo-Facorro, B, Dannlowski, U, David, FS, de Geus, EJC, de Zubicaray, GI, Desrivieres, S, Doherty, JL, Donohoe, G, Ehrlich, S, Eising, E, Espeseth, T, Fisher, SE, Forstner, AJ, Fortaner-Uya, L, Frouin, V, Fukunaga, M, Ge, T, Glahn, DC, Goltermann, J, Grabe, HJ, Green, MJ, Groenewold, NA, Grotegerd, D, Grontvedt, GR, Hahn, T, Hashimoto, R, Hehir-Kwa, JY, Henskens, FA, Holmes, AJ, Haberg, AK, Haavik, J, Jacquemont, S, Jansen, A, Jockwitz, C, Joensson, EG, Kikuchi, M, Kircher, T, Kumar, K, Le Hellard, S, Leu, C, Linden, DE, Liu, J, Loughnan, R, Mather, KA, Mcmahon, KL, Mcrae, AF, Medland, SE, Meinert, S, Moreau, CA, Morris, DW, Mowry, BJ, Muehleisen, TW, Nenadic, I, Noethen, MM, Nyberg, L, Ophoff, RA, Owen, MJ, Pantelis, C, Paolini, M, Paus, T, Pausova, Z, Persson, K, Quide, Y, Marques, TR, Sachdev, PS, Sando, SB, Schall, U, Scott, RJ, Selbaek, G, Shumskaya, E, Silva, AI, Sisodiya, SM, Stein, F, Stein, DJ, Straube, B, Streit, F, Strike, LT, Teumer, A, Teutenberg, L, Thalamuthu, A, Tooney, PA, Tordesillas-Gutierrez, D, Trollor, JN, Van't Ent, D, van den Bree, MBM, van Haren, NEM, Vazquez-Bourgon, J, Voelzke, H, Wen, W, Wittfeld, K, Ching, CRK, Westlye, LT, Thompson, PM, Bearden, CE, Selmer, KK, Alnaes, D, Andreassen, OA, and Sonderby, IE
Abstract: BACKGROUND: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure. METHODS: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference. RESULTS: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness. CONCLUSIONS: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
Published: 2024

19. Cortical similarities in psychiatric and mood disorders identified in federated VBM analysis via COINSTAC

Author: Rootes-Murdy, K, Panta, S, Kelly, R, Romero, J, Quide, Y, Cairns, MJ, Loughland, C, Carr, VJ, Catts, S, Jablensky, A, Green, MJ, Henskens, F, Kiltschewskij, D, Michie, PT, Mowry, B, Pantelis, C, Rasser, PE, Reay, WR, Schall, U, Scott, RJ, Watkeys, OJ, Roberts, G, Mitchell, PB, Fullerton, JM, Overs, BJ, Kikuchi, M, Hashimoto, R, Matsumoto, J, Fukunaga, M, Sachdev, PS, Brodaty, H, Wen, W, Jiang, J, Fani, N, Ely, TD, Lorio, A, Stevens, JS, Ressler, K, Jovanovic, T, van Rooij, SJH, Federmann, LM, Jockwitz, C, Teumer, A, Forstner, AJ, Caspers, S, Cichon, S, Plis, SM, Sarwate, AD, Calhoun, VD, Rootes-Murdy, K, Panta, S, Kelly, R, Romero, J, Quide, Y, Cairns, MJ, Loughland, C, Carr, VJ, Catts, S, Jablensky, A, Green, MJ, Henskens, F, Kiltschewskij, D, Michie, PT, Mowry, B, Pantelis, C, Rasser, PE, Reay, WR, Schall, U, Scott, RJ, Watkeys, OJ, Roberts, G, Mitchell, PB, Fullerton, JM, Overs, BJ, Kikuchi, M, Hashimoto, R, Matsumoto, J, Fukunaga, M, Sachdev, PS, Brodaty, H, Wen, W, Jiang, J, Fani, N, Ely, TD, Lorio, A, Stevens, JS, Ressler, K, Jovanovic, T, van Rooij, SJH, Federmann, LM, Jockwitz, C, Teumer, A, Forstner, AJ, Caspers, S, Cichon, S, Plis, SM, Sarwate, AD, and Calhoun, VD
Abstract: Structural neuroimaging studies have identified a combination of shared and disorder-specific patterns of gray matter (GM) deficits across psychiatric disorders. Pooling large data allows for examination of a possible common neuroanatomical basis that may identify a certain vulnerability for mental illness. Large-scale collaborative research is already facilitated by data repositories, institutionally supported databases, and data archives. However, these data-sharing methodologies can suffer from significant barriers. Federated approaches augment these approaches by enabling access or more sophisticated, shareable and scaled-up analyses of large-scale data. We examined GM alterations using Collaborative Informatics and Neuroimaging Suite Toolkit for Anonymous Computation, an open-source, decentralized analysis application. Through federated analysis of eight sites, we identified significant overlap in the GM patterns (n = 4,102) of individuals with schizophrenia, major depressive disorder, and autism spectrum disorder. These results show cortical and subcortical regions that may indicate a shared vulnerability to psychiatric disorders.
Published: 2024

20. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.

Author: Jiang, Y, Luo, C, Wang, J, Palaniyappan, L, Chang, X, Xiang, S, Zhang, J, Duan, M, Huang, H, Gaser, C, Nemoto, K, Miura, K, Hashimoto, R, Westlye, LT, Richard, G, Fernandez-Cabello, S, Parker, N, Andreassen, OA, Kircher, T, Nenadić, I, Stein, F, Thomas-Odenthal, F, Teutenberg, L, Usemann, P, Dannlowski, U, Hahn, T, Grotegerd, D, Meinert, S, Lencer, R, Tang, Y, Zhang, T, Li, C, Yue, W, Zhang, Y, Yu, X, Zhou, E, Lin, C-P, Tsai, S-J, Rodrigue, AL, Glahn, D, Pearlson, G, Blangero, J, Karuk, A, Pomarol-Clotet, E, Salvador, R, Fuentes-Claramonte, P, Garcia-León, MÁ, Spalletta, G, Piras, F, Vecchio, D, Banaj, N, Cheng, J, Liu, Z, Yang, J, Gonul, AS, Uslu, O, Burhanoglu, BB, Uyar Demir, A, Rootes-Murdy, K, Calhoun, VD, Sim, K, Green, M, Quidé, Y, Chung, YC, Kim, W-S, Sponheim, SR, Demro, C, Ramsay, IS, Iasevoli, F, de Bartolomeis, A, Barone, A, Ciccarelli, M, Brunetti, A, Cocozza, S, Pontillo, G, Tranfa, M, Park, MTM, Kirschner, M, Georgiadis, F, Kaiser, S, Van Rheenen, TE, Rossell, SL, Hughes, M, Woods, W, Carruthers, SP, Sumner, P, Ringin, E, Spaniel, F, Skoch, A, Tomecek, D, Homan, P, Homan, S, Omlor, W, Cecere, G, Nguyen, DD, Preda, A, Thomopoulos, SI, Jahanshad, N, Cui, L-B, Yao, D, Thompson, PM, Turner, JA, van Erp, TGM, Cheng, W, ENIGMA Schizophrenia Consortium, Feng, J, ZIB Consortium, Jiang, Y, Luo, C, Wang, J, Palaniyappan, L, Chang, X, Xiang, S, Zhang, J, Duan, M, Huang, H, Gaser, C, Nemoto, K, Miura, K, Hashimoto, R, Westlye, LT, Richard, G, Fernandez-Cabello, S, Parker, N, Andreassen, OA, Kircher, T, Nenadić, I, Stein, F, Thomas-Odenthal, F, Teutenberg, L, Usemann, P, Dannlowski, U, Hahn, T, Grotegerd, D, Meinert, S, Lencer, R, Tang, Y, Zhang, T, Li, C, Yue, W, Zhang, Y, Yu, X, Zhou, E, Lin, C-P, Tsai, S-J, Rodrigue, AL, Glahn, D, Pearlson, G, Blangero, J, Karuk, A, Pomarol-Clotet, E, Salvador, R, Fuentes-Claramonte, P, Garcia-León, MÁ, Spalletta, G, Piras, F, Vecchio, D, Banaj, N, Cheng, J, Liu, Z, Yang, J, Gonul, AS, Uslu, O, Burhanoglu, BB, Uyar Demir, A, Rootes-Murdy, K, Calhoun, VD, Sim, K, Green, M, Quidé, Y, Chung, YC, Kim, W-S, Sponheim, SR, Demro, C, Ramsay, IS, Iasevoli, F, de Bartolomeis, A, Barone, A, Ciccarelli, M, Brunetti, A, Cocozza, S, Pontillo, G, Tranfa, M, Park, MTM, Kirschner, M, Georgiadis, F, Kaiser, S, Van Rheenen, TE, Rossell, SL, Hughes, M, Woods, W, Carruthers, SP, Sumner, P, Ringin, E, Spaniel, F, Skoch, A, Tomecek, D, Homan, P, Homan, S, Omlor, W, Cecere, G, Nguyen, DD, Preda, A, Thomopoulos, SI, Jahanshad, N, Cui, L-B, Yao, D, Thompson, PM, Turner, JA, van Erp, TGM, Cheng, W, ENIGMA Schizophrenia Consortium, Feng, J, and ZIB Consortium
Abstract: Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal 'trajectory' of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
Published: 2024

21. Longitudinal double spin asymmetries in single hadron quasi-real photoproduction at high $p_T$

Author: COMPASS Collaboration, Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badełek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Büchele, M., Burtin, E., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. -U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Dünnweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Jörg, P., Kabuß, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Krämer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kuchinski, N., Kuhn, R., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matoušek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Nový, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pešek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schönning, K., Schopferer, S., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: We measured the longitudinal double spin asymmetries $A_{LL}$ for single hadron muo-production off protons and deuterons at photon virtuality $Q^2$ < 1(GeV/$\it c$)$^2$ for transverse hadron momenta $p_T$ in the range 0.7 GeV/$\it c$ to 4 GeV/$\it c$ . They were determined using COMPASS data taken with a polarised muon beam of 160 GeV/$\it c$ or 200 GeV/$\it c$ impinging on polarised $\mathrm{{}^6LiD}$ or $\mathrm{NH_3}$ targets. The experimental asymmetries are compared to next-to-leading order pQCD calculations, and are sensitive to the gluon polarisation $\Delta G$ inside the nucleon in the range of the nucleon momentum fraction carried by gluons $0.05 < x_g < 0.2$.
Published: 2015

22. Resonance Production and $\pi\pi$ S-wave in $\pi^- + p \rightarrow \pi^- \pi^- \pi^+ + p_{recoil}$ at 190 GeV/c

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badełek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Büchele, M., Burtin, E., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Dünnweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Jörg, P., Kabuß, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Krämer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matoušek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Nový, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pešek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schlüter, T., Schmidt, K., Schmieden, H., Schönning, K., Schopferer, S., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The COMPASS collaboration has collected the currently largest data set on diffractively produced $\pi^-\pi^-\pi^+$ final states using a negative pion beam of 190 GeV/c momentum impinging on a stationary proton target. This data set allows for a systematic partial-wave analysis in 100 bins of three-pion mass, $0.5 < m_{3\pi} < 2.5$ GeV/c$^2$ , and in 11 bins of the reduced four-momentum transfer squared, $0.1 < t < 1.0$ (GeV/c)$^2$ . This two-dimensional analysis offers sensitivity to genuine one-step resonance production, i.e. the production of a state followed by its decay, as well as to more complex dynamical effects in nonresonant $3\pi$ production. In this paper, we present detailed studies on selected $3\pi$ partial waves with $J^{PC} = 0^{-+}$, $1^{++}$, $2^{-+}$, $2^{++}$, and $4^{++}$. In these waves, we observe the well-known ground-state mesons as well as a new narrow axial-vector meson $a_1(1420)$ decaying into $f_0(980) \pi$. In addition, we present the results of a novel method to extract the amplitude of the $\pi^-\pi^+$ subsystem with $I^{G}J^{PC} = 0^+ 0^{++}$ in various partial waves from the $\pi^-\pi^-\pi^+$ data. Evidence is found for correlation of the $f_0(980)$ and $f_0(1500)$ appearing as intermediate $\pi^- \pi^+$ isobars in the decay of the known $\pi(1800)$ and $\pi_2(1880)$., Comment: 96 pages
Published: 2015
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23. Interplay among transversity induced asymmetries in hadron leptoproduction

Author: Compass Collaboration, Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Büchele, M., Burtin, E., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., d'Hose, N., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Grosse-Perdekamp, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Horikawa, N., Hsieh, C. -Yu, Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jörg, P., Joosten, R., Kabuß, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Krämer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesaro, G., Pesek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schönning, K., Schopferer, S., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Weisrock, T., Wilfert, M., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: In the fragmentation of a transversely polarized quark several left-right asymmetries are possible for the hadrons in the jet. When only one unpolarized hadron is selected, it exhibits an azimuthal modulation known as Collins effect. When a pair of oppositely charged hadrons is observed, three asymmetries can be considered, a di-hadron asymmetry and two single hadron asymmetries. In lepton deep inelastic scattering on transversely polarized nucleons all these asymmetries are coupled with the transversity distribution. From the high statistics COMPASS data on oppositely charged hadron-pair production we have investigated for the first time the dependence of these three asymmetries on the difference of the azimuthal angles of the two hadrons. The similarity of transversity induced single and di-hadron asymmetries is discussed. A new analysis of the data allows to establish quantitative relationships among them, providing for the first time strong experimental indication that the underlying fragmentation mechanisms are all driven by a common physical process., Comment: 6 figures
Published: 2015
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24. The Spin Structure Function $g_1^{\rm p}$ of the Proton and a Test of the Bjorken Sum Rule

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Azevedo, C., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, G. R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Grosse-Perdekamp, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C. -Yu, Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jörg, P., Joosten, R., Kabuß, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Weisrock, T., Wilfert, M., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: New results for the double spin asymmetry $A_1^{\rm p}$ and the proton longitudinal spin structure function $g_1^{\rm p}$ are presented. They were obtained by the COMPASS collaboration using polarised 200 GeV muons scattered off a longitudinally polarised NH$_3$ target. The data were collected in 2011 and complement those recorded in 2007 at 160\,GeV, in particular at lower values of $x$. They improve the statistical precision of $g_1^{\rm p}(x)$ by about a factor of two in the region $x\lesssim 0.02$. A next-to-leading order QCD fit to the $g_1$ world data is performed. It leads to a new determination of the quark spin contribution to the nucleon spin, $\Delta \Sigma$ ranging from 0.26 to 0.36, and to a re-evaluation of the first moment of $g_1^{\rm p}$. The uncertainty of $\Delta \Sigma$ is mostly due to the large uncertainty in the present determinations of the gluon helicity distribution. A new evaluation of the Bjorken sum rule based on the COMPASS results for the non-singlet structure function $g_1^{\rm NS}(x,Q^2)$ yields as ratio of the axial and vector coupling constants $|g_{\rm A}/g_{\rm V}| = 1.22 \pm 0.05~({\rm stat.}) \pm 0.10~({\rm syst.})$, which validates the sum rule to an accuracy of about 9\%., Comment: 19 pages, 8 figures and tables
Published: 2015
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25. Observation of a new narrow axial-vector meson $a_1(1420)$

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Azevedo, C., Badelek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Chang, W. -C., Chiosso, M., Choi, I., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duennweber, W, Duic, V., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Gnesi, I., Gorzellik, M., Grabmueller, S., Grasso, A., Grosse-Perdekamp, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C. -Yu, Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schlueter, T., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Wallner, S., Weisrock, T., Wilfert, M., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment
Abstract: The COMPASS collaboration at CERN has measured diffractive dissociation of 190 GeV/$c$ pions into the $\pi^-\pi^-\pi^+$ final state using a stationary hydrogen target. A partial-wave analysis (PWA) was performed in bins of $3\pi$ mass and four-momentum transfer using the isobar model and the so far largest PWA model consisting of 88 waves. A narrow $J^{PC} = 1^{++}$ signal is observed in the $f_0(980)\,\pi$ channel. We present a resonance-model study of a subset of the spin-density matrix selecting $3\pi$ states with $J^{PC} = 2^{++}$ and $4^{++}$ decaying into $\rho(770)\,\pi$ and with $J^{PC} = 1^{++}$ decaying into $f_0(980)\,\pi$. We identify a new $a_1$ meson with mass $(1414^{+15}_{-13})$ MeV/$c^2$ and width $(153^{+8}_{-23})$ MeV/$c^2$. Within the final states investigated in our analysis, we observe the new $a_1(1420)$ decaying only into $f_0(980)\,\pi$, suggesting its exotic nature., Comment: 8 pages, 1 figure
Published: 2015
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26. Abnormal asymmetries in subcortical brain volume in schizophrenia

Author: Okada, N, Fukunaga, M, Yamashita, F, Koshiyama, D, Yamamori, H, Ohi, K, Yasuda, Y, Fujimoto, M, Watanabe, Y, Yahata, N, Nemoto, K, Hibar, DP, van Erp, TGM, Fujino, H, Isobe, M, Isomura, S, Natsubori, T, Narita, H, Hashimoto, N, Miyata, J, Koike, S, Takahashi, T, Yamasue, H, Matsuo, K, Onitsuka, T, Iidaka, T, Kawasaki, Y, Yoshimura, R, Suzuki, M, Turner, JA, Takeda, M, Thompson, PM, Ozaki, N, Kasai, K, and Hashimoto, R
Subjects: Clinical Research, Mental Health, Brain Disorders, Neurosciences, Schizophrenia, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adult, Amygdala, Basal Ganglia, Brain, Brain Mapping, Cohort Studies, Cross-Sectional Studies, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Putamen, Thalamus, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Subcortical structures, which include the basal ganglia and parts of the limbic system, have key roles in learning, motor control and emotion, but also contribute to higher-order executive functions. Prior studies have reported volumetric alterations in subcortical regions in schizophrenia. Reported results have sometimes been heterogeneous, and few large-scale investigations have been conducted. Moreover, few large-scale studies have assessed asymmetries of subcortical volumes in schizophrenia. Here, as a work completely independent of a study performed by the ENIGMA consortium, we conducted a large-scale multisite study of subcortical volumetric differences between patients with schizophrenia and controls. We also explored the laterality of subcortical regions to identify characteristic similarities and differences between them. T1-weighted images from 1680 healthy individuals and 884 patients with schizophrenia, obtained with 15 imaging protocols at 11 sites, were processed with FreeSurfer. Group differences were calculated for each protocol and meta-analyzed. Compared with controls, patients with schizophrenia demonstrated smaller bilateral hippocampus, amygdala, thalamus and accumbens volumes as well as intracranial volume, but larger bilateral caudate, putamen, pallidum and lateral ventricle volumes. We replicated the rank order of effect sizes for subcortical volumetric changes in schizophrenia reported by the ENIGMA consortium. Further, we revealed leftward asymmetry for thalamus, lateral ventricle, caudate and putamen volumes, and rightward asymmetry for amygdala and hippocampal volumes in both controls and patients with schizophrenia. Also, we demonstrated a schizophrenia-specific leftward asymmetry for pallidum volume. These findings suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the pallidum in schizophrenia.
Published: 2016

27. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author: van Erp, TGM, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MWJ, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NEM, Pol, HEH, Ophoff, RA, Kahn, RS, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jönsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, and Turner, JA
Subjects: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Serious Mental Illness, Brain Disorders, Schizophrenia, Clinical Research, Neurosciences, Mental Health, Biomedical Imaging, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Adult, Brain, Brain Mapping, Case-Control Studies, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prospective Studies, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract: The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=-0.46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12), as well as larger pallidum (d=0.21) and lateral ventricle volumes (d=0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.
Published: 2016

28. The COMPASS Setup for Physics with Hadron Beams

Author: Abbon, Ph., Adolph, C., Akhunzyanov, R., Alexandrov, Yu., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bielert, E. R., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Ciliberti, P., Chiosso, M., Chung, S. U., Cicuttin, A., Colantoni, M., Cotte, D., Crespo, M. L., Curiel, Q., Dafni, T., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Desforge, D., Dinkelbach, A. M., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Durand, D., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gatignon, L., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giganon, A., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Gregori, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kuhn, R., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Marroncle, J., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Menon, G., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Moinester, M. A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesaro, G., Pesaro, V., Peshekhonov, D. V., Pires, C., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Reymond, J-M., Rocco, E., Rossiyskaya, N. S., Rousse, J. -Y., Ryabchikov, D. I., Rychter, A., Samartsev, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Tskhay, V., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Weitzel, Q., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The main characteristics of the COMPASS experimental setup for physics with hadron beams are described. This setup was designed to perform exclusive measurements of processes with several charged and/or neutral particles in the final state. Making use of a large part of the apparatus that was previously built for spin structure studies with a muon beam, it also features a new target system as well as new or upgraded detectors. The hadron setup is able to operate at the high incident hadron flux available at CERN. It is characterised by large angular and momentum coverages, large and nearly flat acceptances, and good two and three-particle mass resolutions. In 2008 and 2009 it was successfully used with positive and negative hadron beams and with liquid hydrogen and solid nuclear targets. This article describes the new and upgraded detectors and auxiliary equipment, outlines the reconstruction procedures used, and summarises the general performance of the setup., Comment: 91 pages, 101 figures and 7 tables
Published: 2014
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29. Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised proton

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bielert, E. R., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment
Abstract: Measurements of the Collins and Sivers asymmetries for charged pions and charged and neutral kaons produced in semi-inclusive deep-inelastic scattering of high energy muons off transversely polarised protons are presented. The results were obtained using all the available COMPASS proton data, which were taken in the years 2007 and 2010. The Collins asymmetries exhibit in the valence region a non-zero signal for pions and there are hints of non-zero signal also for kaons. The Sivers asymmetries are found to be positive for positive pions and kaons and compatible with zero otherwise., Comment: 15 pages, 13 figures and 1 table
Published: 2014
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30. Odd and Even Partial Waves of $\eta\pi^-$ and $\eta'\pi^-$ in $\pi^-p\to\eta^{(\prime)}\pi^-p$ at $191\,\textrm{GeV}/c$

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bielert, E. R., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: Exclusive production of $\eta\pi^-$ and $\eta'\pi^-$ has been studied with a $191\,\textrm{GeV}/c$ $\pi^-$ beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum ($L$) characteristics in the inspected invariant mass range up to $3\,\textrm{GeV}/c^2$. A striking similarity between the two systems is observed for the $L=2,4,6$ intensities (scaled by kinematical factors) and the relative phases. The known resonances $a_2(1320)$ and $a_4(2040)$ are in line with this similarity. In contrast, a strong enhancement of $\eta'\pi^-$ over $\eta\pi^-$ is found for the $L=1,3,5$ waves, which carry non-$q\bar q$ quantum numbers. The $L=1$ intensity peaks at $1.7\,\textrm{GeV}/c^2$ in $\eta'\pi^-$ and at $1.4\,\textrm{GeV}/c^2$ in $\eta\pi^-$, the corresponding phase motions with respect to $L=2$ are different., Comment: 16 pages, 5 figures and 1 table
Published: 2014
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31. Search for exclusive photoproduction of Z$_c^{\pm}$(3900) at COMPASS

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bielert, E. R., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment
Abstract: A search for the exclusive production of the $Z_c^{\pm}(3900)$ hadron by virtual photons has been performed in the channel $Z_c^{\pm}(3900)\rightarrow J/\psi \pi^{\pm}$. The data cover the range from 7 GeV to 19 GeV in the centre-of-mass energy of the photon-nucleon system. The full set of the COMPASS data set collected with a muon beam between 2002 and 2011 has been used. An upper limit for the ratio $BR(Z_c^{\pm}(3900)\rightarrow J/\psi \pi^{\pm} )\times \sigma_{ \gamma~N \rightarrow Z_c^{\pm}(3900)~ N} /\sigma_{\gamma~N \rightarrow J/\psi~ N}$ of $3.7\times10^{-3}$ has been established at the confidence level of 90%., Comment: 8 pages, 3 figures, 1 table
Published: 2014
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32. Spin alignment and violation of the OZI rule in exclusive $\omega$ and $\phi$ production in pp collisions

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger, r. M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Grussenmeyer, T., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, h., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, u., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, u. A., Kisselev, u., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, u. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Peshekhonov, D., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: Exclusive production of the isoscalar vector mesons $\omega$ and $\phi$ is measured with a 190 GeV$/c$ proton beam impinging on a liquid hydrogen target. Cross section ratios are determined in three intervals of the Feynman variable $x_{F}$ of the fast proton. A significant violation of the OZI rule is found, confirming earlier findings. Its kinematic dependence on $x_{F}$ and on the invariant mass $M_{p\mathrm{V}}$ of the system formed by fast proton $p_\mathrm{fast}$ and vector meson $V$ is discussed in terms of diffractive production of $p_\mathrm{fast}V$ resonances in competition with central production. The measurement of the spin density matrix element $\rho_{00}$ of the vector mesons in different selected reference frames provides another handle to distinguish the contributions of these two major reaction types. Again, dependences of the alignment on $x_{F}$ and on $M_{p\mathrm{V}}$ are found. Most of the observations can be traced back to the existence of several excited baryon states contributing to $\omega$ production which are absent in the case of the $\phi$ meson. Removing the low-mass $M_{p\mathrm{V}}$ resonant region, the OZI rule is found to be violated by a factor of eight, independently of $x_\mathrm{F}$., Comment: 23 pages, 13 figures and 5 tables
Published: 2014
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33. Measurement of the charged-pion polarisability

Author: Adolph, C., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Colantoni, M., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dinkelbach, A. M., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger, M. jr., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Grussenmeyer, T., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kuhn, R., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Moinester, M. A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Peshekhonov, D., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Rocco, E., Rossiyskaya, N. S., Ryabchikov, D. I., Rychter, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Virius, M., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: The COMPASS collaboration at CERN has investigated pion Compton scattering, $\pi^-\gamma\rightarrow \pi^-\gamma$, at centre-of-mass energy below 3.5 pion masses. The process is embedded in the reaction $\pi^-\mathrm{Ni}\rightarrow\pi^-\gamma\;\mathrm{Ni}$, which is initiated by 190\,GeV pions impinging on a nickel target. The exchange of quasi-real photons is selected by isolating the sharp Coulomb peak observed at smallest momentum transfers, $Q^2<0.0015$\,(GeV/$c$)$^2$. From a sample of 63\,000 events the pion electric polarisability is determined to be $\alpha_\pi\ =\ (\,2.0\ \pm\ 0.6_{\mbox{\scriptsize stat}}\ \pm\ 0.7_{\mbox{\scriptsize syst}}\,) \times 10^{-4}\,\mbox{fm}^3$ under the assumption $\alpha_\pi=-\beta_\pi$, which relates the electric and magnetic dipole polarisabilities. It is the most precise measurement of this fundamental low-energy parameter of strong interaction, that has been addressed since long by various methods with conflicting outcomes. While this result is in tension with previous dedicated measurements, it is found in agreement with the expectation from chiral perturbation theory. An additional measurement replacing pions by muons, for which the cross-section behavior is unambigiously known, was performed for an independent estimate of the systematic uncertainty., Comment: Published version: 9 pages, 3 figures, 1 table
Published: 2014
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34. Measurement of radiative widths of $a_2(1320)$ and $\pi_2(1670)$

Author: Adolph, C., Akhunzyanov, R., Alekseev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger~jr., M., Fischer, H., Franco, C., du~Fresne~von~Hohenesche, N., Friedrich, J. M., Frolov, V., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kral, Z., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Orlov, I., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, E., Rychter, A., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter~Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., and Ziembicki., M.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The COMPASS Collaboration at CERN has investigated the reaction $\pi^- \gamma \rightarrow \pi^-\pi^-\pi^+$ embedded in the Primakoff reaction of $190~\textrm{GeV}$ pions scattering in the Coulomb field of a lead target, $\pi^- \text{Pb} \rightarrow \pi^-\pi^-\pi^+ \text{Pb}$. Exchange of quasi-real photons is selected by isolating the sharp Coulomb peak observed at momentum transfer below $0.001~(\text{GeV}/c)^2$. Using a partial-wave analysis the amplitudes and relative phases of the $a_2(1320)$ and $\pi_2(1670)$ mesons have been extracted, and the Coulomb and the diffractive contributions have been disentangled. Measuring absolute production cross sections we have determined the radiative width of the $a_2(1320)$ to be $\Gamma_0(a_2(1320) \rightarrow \pi\gamma) = (358 \pm 6_{\textrm{stat}} \pm 42_{\textrm{syst}})~\textrm{keV}$. As the first measurement, $\Gamma_0(\pi_2(1670) \rightarrow \pi\gamma) = (181 \pm 11_{\textrm{stat}} \pm 27_{\textrm{syst}})~\textrm{keV} \cdot (\textrm{BR}^{\textrm{PDG}}_{f_2 \pi}/\textrm{BR}_{f_2 \pi})$ is obtained for the radiative width of the $\pi_2(1670)$, where in this analysis the branching ratio $\textrm{BR}^{\textrm{PDG}}_{f_2 \pi}=0.56$ has been used. We compare these values to previous measurements and theoretical predictions., Comment: 27 pages, 12 figures and 3 tables
Published: 2014
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35. A high-statistics measurement of transverse spin effects in dihadron production from muon-proton semi-inclusive deep-inelastic scattering

Author: Adolph, C., Akhunzyanov, R., Alekseev, M. G., Alexandrov, Yu., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bravar, A., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, M., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kral, Z., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Orlov, I., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Peshekhonov, D., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, E., Rodionov, V., Rondio, E., Rychter, A., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabeleski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., and Ziembicki, M.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: A measurement of the azimuthal asymmetry in dihadron production in deep-inelastic scattering of muons on transversely polarised proton (NH$_{3}$) targets are presented. They provide independent access to the transversity distribution functions through the measurement of the Collins asymmetry in single hadron production. The data were taken in the year $2010$ with the COMPASS spectrometer using a $160\,\mbox{GeV}/c$ muon beam of the CERN SPS, increasing by a factor of about three the available statistics of the previously published data taken in the year $2007$. The measured sizeable asymmetry is in good agreement with the published data. An approximate equality of the Collins asymmetry and the dihadron asymmetry is observed, suggesting a common physical mechanism in the underlying fragmentation., Comment: 14 pages, 8 figures
Published: 2014
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36. Measurement of azimuthal hadron asymmetries in semi-inclusive deep inelastic scattering off unpolarised nucleons

Author: Adolph, C., Akhunzyanov, R., Alekseev, M. G., Alexandrov, Yu., Alexeev, G. D., Amoroso, A., Andrieux, V., Anosov, V., Austregesilo, A., Badelek, B., Balestra, F., Barth, J., Baum, G., Beck, R., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bravar, A., Bressan, A., Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Donskov, S. V., Doshita, N., Duic, V., Duennweber, W., Dziewiecki, M., Efremov, A., Elia, C., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, M., Gnesi, I., Gobbo, B., Goertz, S., Gorzellik, M., Grabmueller, S., Grasso, A., Grube, B., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Hashimoto, R., Heinsius, F. H., Herrmann, F., Hinterberger, F., Hoeppner, Ch., Horikawa, N., d'Hose, N., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joerg, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kral, Z., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, S., Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Marchand, C., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Yu. V., Miyachi, Y., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. -D., Nunes, A. S., Orlov, I., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Peshekhonov, D., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, E., Rodionov, V., Rondio, E., Rychter, A., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schiavon, P., Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, F., Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Szabeleski, A., Szameitat, T., Sznajder, P., Takekawa, S., ter Wolbeek, J., Tessaro, S., Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., and Ziembicki, M.
Subjects: High Energy Physics - Experiment
Abstract: Spin-averaged asymmetries in the azimuthal distributions of positive and negative hadrons produced in deep inelastic scattering were measured using the CERN SPS muon beam at $160$ GeV/c and a $^6$LiD target. The amplitudes of the three azimuthal modulations $\cos\phi_h$, $\cos2\phi_h$ and $\sin\phi_h$ were obtained binning the data separately in each of the relevant kinematic variables $x$, $z$ or $p_T^{\,h}$ and binning in a three-dimensional grid of these three variables. The amplitudes of the $\cos \phi_h$ and $\cos 2\phi_h$ modulations show strong kinematic dependencies both for positive and negative hadrons., Comment: 33 pages, 15 figures and 10 pages
Published: 2014
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37. Effect of strong localization of doped holes in angle-resolved photoemission spectra of La$_{1-x}$Sr$_x$FeO$_3$

Author: Wadati, H., Chikamatsu, A., Takizawa, M., Hashimoto, R., Kumigashira, H., Yoshida, T., Mizokawa, T., Fujimori, A., Oshima, M., Lippmaa, M., Kawasaki, M., and Koinuma, H.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract: We have performed an angle-resolved photoemission spectroscopy study of La$_{0.6}$Sr$_{0.4}$FeO$_3$ using {\it in situ} prepared thin films and determined its band structure. The experimental band dispersions could be well explained by an empirical band structure assuming the G-type antiferromagnetic state. However, the Fe 3d bands were found to be shifted downward relative to the Fermi level ($E_F$) by $\sim 1$ eV compared with the calculation and to form a (pseudo)gap of $\sim 1$ eV at $E_F$. We attribute this observation to a strong localization effect of doped holes due to polaron formation., Comment: 5 pages, 5 figures
Published: 2006
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38. Robust Ti4+ states in SrTiO3 layers of La0.6Sr0.4MnO3/SrTiO3/ La0.6Sr0.4MnO3 junctions

Author: Kumigashira, H., Chikamatsu, A., Hashimoto, R., Oshima, M., Ohnishi, T., Lippmaa, M., Wadati, H., Fujimori, A., Ono, K., Kawasaki, M., and Koinuma, H.
Subjects: Condensed Matter - Strongly Correlated Electrons
Abstract: We have investigated the interfacial electronic structure of La0.6Sr0.4MnO3 (LSMO)/ SrTiO3 (STO)/ LSMO heterojunctions utilizing the elemental selectivity of photoemission spectroscopy. The Ti 2p core-level spectra clearly show Ti4+ states and do not exhibit any indication of Ti3+ states in TiO2 layers irrespective of a different kind of adjacent atomic layer with different chemical carrier concentration. This result indicates that the Ti ions in the TiO2 atomic layers preserve their tetravalent states even in the vicinity of the valence-mismatched interface between LSMO and STO, reflecting chemical stability of the Ti4+ states., Comment: 12 pages, 3 figures
Published: 2005
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39. Temperature-dependent soft x-ray photoemission and absorption studies of charge disproportionation in La$_{1-x}$Sr$_x$FeO$_3$

Author: Wadati, H., Chikamatsu, A., Hashimoto, R., Takizawa, M., Kumigashira, H., Fujimori, A., Oshima, M., Lippmaa, M., Kawasaki, M., and Koinuma, H.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract: We have measured the temperature dependence of the photoemission and x-ray absorption spectra of La$_{1-x}$Sr$_x$FeO$_3$ (LSFO) epitaxial thin films with $x=0.67$, where charge disproportionation ($3{Fe}^{3.67+}\to 2{Fe}^{3+}+ {Fe}^{5+}$) resulting in long-range spin and charge ordering is known to occur below $T_{CD}=190$ K. With decreasing temperature we observed gradual changes of the spectra with spectral weight transfer over a wide energy range of $\sim 5$ eV. Above $T_{CD}$ the intensity at the Fermi level ($E_F$) was relatively high compared to that below $T_{CD}$ but still much lower than that in conventional metals. We also found a similar temperature dependence for $x=0.4$, and to a lesser extent for $x=0.2$. These observations suggest that a local charge disproportionation occurs not only in the $x=0.67$ sample below $T_{CD}$ but also over a wider temperature and composition range in LSFO. This implies that the tendency toward charge disproportionation may be the origin of the unusually wide insulating region of the LSFO phase diagram., Comment: 6 pages, 8 figures
Published: 2004
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40. Exclusive ω meson muoproduction on transversely polarised protons

Author: Adolph, C., Aghasyan, M., Akhunzyanov, R., Alexeev, M.G., Alexeev, G.D., Amoroso, A., Andrieux, V., Anfimov, N.V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C.D.R., Badełek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E.R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Büchele, M., Chang, W.-C., Chatterjee, C., Chiosso, M., Choi, I., Chung, S.-U., Cicuttin, A., Crespo, M.L., Curiel, Q., Dalla Torre, S., Dasgupta, S.S., Dasgupta, S., Denisov, O.Yu., Dhara, L., Donskov, S.V., Doshita, N., Duic, V., Dünnweber, W., Dziewiecki, M., Efremov, A., Eversheim, P.D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., Finger, M., Jr., Fischer, H., Franco, C., du Fresne von Hohenesche, N., Friedrich, J.M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O.P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Grosse Perdekamp, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F.H., Heitz, R., Herrmann, F., Hinterberger, F., Horikawa, N., d'Hose, N., Hsieh, C.-Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Jörg, P., Kabuß, E., Ketzer, B., Khaustov, G.V., Khokhlov, Yu.A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J.H., Kolosov, V.N., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V.F., Kotzinian, A.M., Kouznetsov, O.M., Krämer, M., Kremser, P., Krinner, F., Kroumchtein, Z.V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R.P., Lednev, A.A., Lehmann, A., Levillain, M., Levorato, S., Lian, Y.-S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G.K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matoušek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G.V., Meyer, M., Meyer, W., Michigami, T., Mikhailov, Yu.V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V.I., Nový, J., Nowak, W.-D., Nukazuka, G., Nunes, A.S., Olshevsky, A.G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J.-C., Pereira, F., Pešek, M., Peshekhonov, D.V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V.A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Roskot, M., Ryabchikov, D.I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V.D., Sandacz, A., Santos, C., Sarkar, S., Savin, I.A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schönning, K., Schopferer, S., Seder, E., Selyunin, A., Shevchenko, O.Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Sozzi, F., Srnka, A., Steffen, D., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tasevsky, M., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Vondra, J., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., and Zink, A.
Published: 2017
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41. 1203 Increased horizontal cell division and suppressed cell differentiation of pigmented basal keratinocytes in senile lentigo

Author: Yoshikawa-Murakami, C., primary, Hashimoto, R., additional, Kishida, S., additional, Atsugi, T., additional, and Mizutani, Y., additional
Published: 2023
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42. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Author: Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, Francks, C., Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, and Francks, C.
Abstract: Item does not contain fulltext, Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Published: 2023

43. Large- scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Author: Schijven, D, Postema, MC, Fukunaga, M, Matsumoto, J, Miura, K, de Zwarte, SMC, van Haren, NEM, Cahn, W, Pol, HEH, Kahn, RS, Ayesa-Arriola, R, de la Foz, VO-G, Tordesillas-Gutierrez, D, Vazquez-Bourgon, J, Crespo-Facorro, B, Alnaes, D, Dahl, A, Westlye, LT, Agartz, I, Andreassen, OA, Jonsson, EG, Kochunov, P, Bruggemann, JM, Catts, SV, Michie, PT, Mowry, BJ, Quide, Y, Rasser, PE, Schall, U, Scott, RJ, Carr, VJ, Green, MJ, Henskens, FA, Loughland, CM, Pantelis, C, Weickert, CS, Weickert, TW, De Haan, L, Brosch, K, Pfarr, J-K, Ringwald, KG, Stein, F, Jansen, A, Kircher, TTJ, Nenadic, I, Kramer, B, Gruber, O, Satterthwaite, TD, Bustillo, J, Mathalon, DH, Preda, A, Calhoun, VD, Ford, JM, Potkin, SG, Chen, J, Tan, Y, Wang, Z, Xiang, H, Fan, F, Bernardoni, F, Ehrlich, S, Fuentes-Claramonte, P, Garcia-Leon, MA, Guerrero-Pedraza, A, Salvador, R, Sarro, S, Pomarol-Clotet, E, Ciullo, V, Piras, F, Vecchio, D, Banaj, N, Spalletta, G, Michielse, S, van Amelsvoort, T, Dickie, EW, Voineskos, AN, Sim, K, Ciufolini, S, Dazzan, P, Murray, RM, Kim, W-S, Chung, Y-C, Andreou, C, Schmidt, A, Borgwardt, S, McIntosh, AM, Whalley, HC, Lawrie, SM, Du Plessis, S, Luckhoff, HK, Scheffler, F, Emsley, R, Grotegerd, D, Lencer, R, Dannlowski, U, Edmond, JT, Rootes-Murdy, K, Stephen, JM, Mayer, AR, Antonucci, LA, Fazio, L, Pergola, G, Bertolino, A, Diaz-Caneja, CM, Janssen, J, Lois, NG, Arango, C, Tomyshev, AS, Lebedeva, I, Cervenkav, S, Sellgrenv, CM, Georgiadis, F, Kirschner, M, Kaiser, S, Hajek, T, Skoch, A, Spaniel, F, Kim, M, Bin Kwak, Y, Oh, S, Kwon, JS, James, A, Bakker, G, Knochel, C, Stablein, M, Oertel, V, Uhlmann, A, Howells, FM, Stein, DJ, Temmingh, HS, Diaz-Zuluaga, AM, Pineda-Zapata, JA, Lopez-Jaramillo, C, Homan, S, Ji, E, Surbeck, W, Homan, P, Fishera, SE, Franke, B, Glahn, DC, Gur, RC, Hashimoto, R, Jahanshad, N, Luders, E, Medland, SE, Thompson, PM, Turner, JA, van Erp, TGM, Francks, C, Schijven, D, Postema, MC, Fukunaga, M, Matsumoto, J, Miura, K, de Zwarte, SMC, van Haren, NEM, Cahn, W, Pol, HEH, Kahn, RS, Ayesa-Arriola, R, de la Foz, VO-G, Tordesillas-Gutierrez, D, Vazquez-Bourgon, J, Crespo-Facorro, B, Alnaes, D, Dahl, A, Westlye, LT, Agartz, I, Andreassen, OA, Jonsson, EG, Kochunov, P, Bruggemann, JM, Catts, SV, Michie, PT, Mowry, BJ, Quide, Y, Rasser, PE, Schall, U, Scott, RJ, Carr, VJ, Green, MJ, Henskens, FA, Loughland, CM, Pantelis, C, Weickert, CS, Weickert, TW, De Haan, L, Brosch, K, Pfarr, J-K, Ringwald, KG, Stein, F, Jansen, A, Kircher, TTJ, Nenadic, I, Kramer, B, Gruber, O, Satterthwaite, TD, Bustillo, J, Mathalon, DH, Preda, A, Calhoun, VD, Ford, JM, Potkin, SG, Chen, J, Tan, Y, Wang, Z, Xiang, H, Fan, F, Bernardoni, F, Ehrlich, S, Fuentes-Claramonte, P, Garcia-Leon, MA, Guerrero-Pedraza, A, Salvador, R, Sarro, S, Pomarol-Clotet, E, Ciullo, V, Piras, F, Vecchio, D, Banaj, N, Spalletta, G, Michielse, S, van Amelsvoort, T, Dickie, EW, Voineskos, AN, Sim, K, Ciufolini, S, Dazzan, P, Murray, RM, Kim, W-S, Chung, Y-C, Andreou, C, Schmidt, A, Borgwardt, S, McIntosh, AM, Whalley, HC, Lawrie, SM, Du Plessis, S, Luckhoff, HK, Scheffler, F, Emsley, R, Grotegerd, D, Lencer, R, Dannlowski, U, Edmond, JT, Rootes-Murdy, K, Stephen, JM, Mayer, AR, Antonucci, LA, Fazio, L, Pergola, G, Bertolino, A, Diaz-Caneja, CM, Janssen, J, Lois, NG, Arango, C, Tomyshev, AS, Lebedeva, I, Cervenkav, S, Sellgrenv, CM, Georgiadis, F, Kirschner, M, Kaiser, S, Hajek, T, Skoch, A, Spaniel, F, Kim, M, Bin Kwak, Y, Oh, S, Kwon, JS, James, A, Bakker, G, Knochel, C, Stablein, M, Oertel, V, Uhlmann, A, Howells, FM, Stein, DJ, Temmingh, HS, Diaz-Zuluaga, AM, Pineda-Zapata, JA, Lopez-Jaramillo, C, Homan, S, Ji, E, Surbeck, W, Homan, P, Fishera, SE, Franke, B, Glahn, DC, Gur, RC, Hashimoto, R, Jahanshad, N, Luders, E, Medland, SE, Thompson, PM, Turner, JA, van Erp, TGM, and Francks, C
Abstract: Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Published: 2023

44. Leading-order determination of the gluon polarisation from semi-inclusive deep inelastic scattering data

Author: Adolph, C., Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badełek, B., Balestra, F., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bisplinghoff, J., Bodlak, M., Boer, M., Bordalo, P., Bradamante, F., Braun, C., Bressan, A., Büchele, M., Chang, W.-C., Chiosso, M., Choi, I., Chung, S.-U., Cicuttin, A., Crespo, M. L., Curiel, Q., Dalla Torre, S., Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Duic, V., Dünnweber, W., Dziewiecki, M., Efremov, A., Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Finger, M., jr., M. Finger, Fischer, H., Franco, C., du Fresne von Hohenesche, N., Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giordano, F., Gnesi, I., Gorzellik, M., Grabmüller, S., Grasso, A., Grosse Perdekamp, M., Grube, B., Grussenmeyer, T., Guskov, A., Haas, F., Hahne, D., von Harrach, D., Hashimoto, R., Heinsius, F. H., Heitz, R., Herrmann, F., Hinterberger, F., Horikawa, N., d’Hose, N., Hsieh, C.-Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jahn, R., Jary, V., Joosten, R., Jörg, P., Kabuß, E., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Krämer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levillain, M., Levorato, S., Lichtenstadt, J., Longo, R., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matoušek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, W., Michigami, T., Mikhailov, Yu. V., Mikhasenko, M., Miyachi, Y., Montuenga, P., Nagaytsev, A., Nerling, F., Neyret, D., Nikolaenko, V. I., Nový, J., Nowak, W.-D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J.-C., Pereira, F., Pešek, M., Peshekhonov, D. V., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Roskot, M., Rossiyskaya, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schönning, K., Schopferer, S., Seder, E., Selyunin, A., Shevchenko, O. Yu., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Sozzi, F., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Takekawa, S., Tasevsky, M., Tessaro, S., Tessarotto, F., Thibaud, F., Tosello, F., Tskhay, V., Uhl, S., Veloso, J., Virius, M., Vondra, J., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Ziembicki, M., Zink, A., and COMPASS Collaboration
Published: 2017
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45. High-resolution copy number variation analysis of schizophrenia in Japan

Author: Kushima, I, Aleksic, B, Nakatochi, M, Shimamura, T, Shiino, T, Yoshimi, A, Kimura, H, Takasaki, Y, Wang, C, Xing, J, Ishizuka, K, Oya-Ito, T, Nakamura, Y, Arioka, Y, Maeda, T, Yamamoto, M, Yoshida, M, Noma, H, Hamada, S, Morikawa, M, Uno, Y, Okada, T, Iidaka, T, Iritani, S, Yamamoto, T, Miyashita, M, Kobori, A, Arai, M, Itokawa, M, Cheng, M -C, Chuang, Y -A, Chen, C -H, Suzuki, M, Takahashi, T, Hashimoto, R, Yamamori, H, Yasuda, Y, Watanabe, Y, Nunokawa, A, Someya, T, Ikeda, M, Toyota, T, Yoshikawa, T, Numata, S, Ohmori, T, Kunimoto, S, Mori, D, Iwata, N, and Ozaki, N
Published: 2017
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46. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients (vol 12, 278, 2022)

Author: Schubert, KO, Thalamuthu, A, Amare, AT, Frank, J, Streit, F, Adl, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, J-M, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Marie-Claire, C, Cearns, M, Cervantes, P, Chen, H-C, Chillotti, C, Cichon, S, Clark, SR, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, Y-H, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kuo, P-H, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, Konig, B, Kusumi, I, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, S, Colom, F, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nothen, MM, Novak, T, O'Donovan, C, Ozaki, N, Osby, U, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Squassina, A, Stamm, T, Stopkova, P, Tekola-Ayele, F, Tortorella, A, Turecki, G, Veeh, J, Vieta, E, Witt, SH, Roberts, G, Zandi, PP, Alda, M, Bauer, M, McMahon, FJ, Mitchell, PB, Schulze, TG, Rietschel, M, Baune, BT, Schubert, KO, Thalamuthu, A, Amare, AT, Frank, J, Streit, F, Adl, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, J-M, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Marie-Claire, C, Cearns, M, Cervantes, P, Chen, H-C, Chillotti, C, Cichon, S, Clark, SR, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Degenhardt, F, Del Zompo, M, DePaulo, JR, Etain, B, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Heilbronner, U, Herms, S, Hoffmann, P, Hou, L, Hsu, Y-H, Jamain, S, Jimenez, E, Kahn, J-P, Kassem, L, Kuo, P-H, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, Konig, B, Kusumi, I, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, S, Colom, F, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nothen, MM, Novak, T, O'Donovan, C, Ozaki, N, Osby, U, Papiol, S, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shekhtman, T, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Squassina, A, Stamm, T, Stopkova, P, Tekola-Ayele, F, Tortorella, A, Turecki, G, Veeh, J, Vieta, E, Witt, SH, Roberts, G, Zandi, PP, Alda, M, Bauer, M, McMahon, FJ, Mitchell, PB, Schulze, TG, Rietschel, M, and Baune, BT
Published: 2022

47. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

Author: Sønderby, I.E., Ching, CRK, Thomopoulos, S.I., van der Meer, D., Sun, D., Villalon-Reina, J.E., Agartz, I., Amunts, K., Arango, C., Armstrong, N.J., Ayesa-Arriola, R., Bakker, G., Bassett, A.S., Boomsma, D.I., Bülow, R., Butcher, N.J., Calhoun, V.D., Caspers, S., Chow, EWC, Cichon, S., Ciufolini, S., Craig, M.C., Crespo-Facorro, B., Cunningham, A.C., Dale, A.M., Dazzan, P., de Zubicaray, G.I., Djurovic, S., Doherty, J.L., Donohoe, G., Draganski, B., Durdle, C.A., Ehrlich, S., Emanuel, B.S., Espeseth, T., Fisher, S.E., Ge, T., Glahn, D.C., Grabe, H.J., Gur, R.E., Gutman, B.A., Haavik, J., Håberg, A.K., Hansen, L.A., Hashimoto, R., Hibar, D.P., Holmes, A.J., Hottenga, J.J., Hulshoff Pol, H.E., Jalbrzikowski, M., Knowles, EEM, Kushan, L., Linden, DEJ, Liu, J., Lundervold, A.J., Martin-Brevet, S., Martínez, K., Mather, K.A., Mathias, S.R., McDonald-McGinn, D.M., McRae, A.F., Medland, S.E., Moberget, T., Modenato, C., Monereo Sánchez, J., Moreau, C.A., Mühleisen, T.W., Paus, T., Pausova, Z., Prieto, C., Ragothaman, A., Reinbold, C.S., Reis Marques, T., Repetto, G.M., Reymond, A., Roalf, D.R., Rodriguez-Herreros, B., Rucker, J.J., Sachdev, P.S., Schmitt, J.E., Schofield, P.R., Silva, A.I., Stefansson, H., Stein, D.J., Tamnes, C.K., Tordesillas-Gutiérrez, D., Ulfarsson, M.O., Vajdi, A., van 't Ent, D., van den Bree, MBM, Vassos, E., Vázquez-Bourgon, J., Vila-Rodriguez, F., Walters, G.B., Wen, W., Westlye, L.T., Wittfeld, K., Zackai, E.H., Stefánsson, K., Jacquemont, S., Thompson, P.M., Bearden, C.E., Andreassen, O.A., ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group, Bernard, M., Blackburn, N.B., Bøen, R., de Geus, E., de Zwarte, SMC, Forti, M.D., Frei, O., Fukunaga, M., Hehir-Kwa, J.Y., Hillegers, MHJ, Hoffmann, P., Homuth, G., Jahanshad, N., Koops, S., Kumar, K., Kikuchi, M., Le Hellard, S., Leu, C., Murray, R.M., Naerland, T., Nyberg, L., Ophoff, R.A., Pike, G.B., Sando, S.B., Shin, J., Shumskaya, E., Sisodiya, S.M., Steen, V.M., Teumer, A., Uhlmann, A., Wright, M.J., Antshel, K.M., Campbell, L.E., Crossley, N.A., Crowley, T.B., Daly, E., Fiksinski, A.M., Forsyth, J.K., Fremont, W., Goodrich-Hunsaker, N.J., Gudbrandsen, M., Jonas, R.K., Kates, W.R., Lin, A., McCabe, K.L., Moss, H., Murphy, D.G., Murphy, K.C., Owen, M.J., Ruparel, K., Simon, T.J., van Amelsvoort, T., and Vorstman, JAS
Subjects: brain structural imaging, copy number variant, diffusion tensor imaging, evolution, genetics-first approach, neurodevelopmental disorders, psychiatric disorders
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This "genotype-first" approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.
Published: 2022

48. Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure: the supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial

Author: Sakata, Yasuhiko, Shiba, Nobuyuki, Takahashi, Jun, Miyata, Satoshi, Nochioka, Kotaro, Miura, Masanobu, Takada, Tsuyoshi, Saga, Chiharu, Shinozaki, Tsuyoshi, Sugi, Masafumi, Nakagawa, Makoto, Sekiguchi, Nobuyo, Komaru, Tatsuya, Kato, Atsushi, Fukuchi, Mitsumasa, Nozaki, Eiji, Hiramoto, Tetsuya, Inoue, Kanichi, Goto, Toshikazu, Ohe, Masatoshi, Tamaki, Kenji, Ibayashi, Setsuro, Ishide, Nobumasa, Maruyama, Yukio, Tsuji, Ichiro, Shimokawa, Hiroaki, Shimokawa, H., Fukuchi, M., Goto, T., Hiramoto, T., Inoue, K., Kato, A., Komaru, T., Ohe, M., Sekiguchi, N., Shiba, N., Shinozaki, T., Sugi, M., Tamaki, K., Hiramoto, T., Inoue, K., Kato, A., Ogata, M., Sato, S., Sugi, M., Ishide, N., Ibayashi, S., Maruyama, Y., Ohno, I., Tamaki, K., Ogawa, H., Kitakaze, M., Tsuji, I., Watanabe, T., Sugiyama, K., Oyama, S., Nozaki, E., Nakamura, A., Takahashi, T., Endo, H., Fukui, S., Nakajima, S., Nakagawa, M., Nozaki, T., Yagi, T., Horiguchi, S., Fushimi, E., Sugai, Y., Takeda, S., Fukahori, K., Aizawa, K., Ohe, M., Tashima, T., Sakurai, K., Kobayashi, T., Goto, T., Matsui, M., Tamada, Y., Yahagi, T., Fukui, A., Takahashi, K., Takahashi, K., Kikuchi, Y., Akai, K., Kanno, H., Kaneko, J., Suzuki, S., Takahashi, K., Akai, K., Katayose, D., Onodera, S., Hiramoto, T., Komatsu, S., Chida, M., Iwabuchi, K., Takeuchi, M., Yahagi, H., Takahashi, N., Otsuka, K., Koseki, Y., Morita, M., Shinozaki, T., Ishizuka, T., Onoue, N., Yamaguchi, N., Fujita, H., Katoh, A., Namiuchi, S., Sugie, T., Saji, K., Takii, T., Sugimura, A., Ohashi, J., Fukuchi, M., Ogata, M., Tanikawa, T., Kitamukai, O., Matsumoto, Y., Inoue, K., Koyama, J., Tomioka, T., Shioiri, H., Ito, Y., Kato, H., Takahashi, C., Kawana, A., Sakata, Y., Ito, K., Nakayama, M., Fukuda, K., Takahashi, J., Miyata, S., Sugimura, K., Sato, K., Matsumoto, Y., Nakano, M., Shiroto, T., Tsuburaya, R., Nochioka, K., Yamamoto, H., Aoki, T., Hao, K., Miura, M., Kondo, M., Tatebe, S., Yamamoto, S., Suzuki, H., Nishimiya, K., Yaoita, N., Sugi, M., Yamamoto, Y., Toda, S., Minatoya, Y., Takagi, Y., Hasebe, Y., Nihei, T., Hanawa, K., Fukuda, K., Sakata, Y., Takahashi, J., Miyata, S., Nochioka, K., Miura, M., Tadaki, S., Ushigome, R., Yamauchi, T., Sato, K., Tsuji, K., Onose, T., Abe, R., Saga, C., Suenaga, J., Yamada, Y., Kimura, J., Ogino, H., Oikawa, I., Watanabe, S., Saga, M., Washio, M., Nagasawa, K., Nagasawa, S., Kotaka, S., Komatsu, W., Hashimoto, R., Ikeno, Y., Suzuki, T., and Hamada, H.
Published: 2015
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49. HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders

Author: Le Clerc, S, Lombardi, L, Baune, BT, Amare, AT, Schubert, KO, Hou, L, Clark, SR, Papiol, S, Cearns, M, Heilbronner, U, Degenhardt, F, Tekola-Ayele, F, Hsu, YH, Shekhtman, T, Adli, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Brichant-Petitjean, C, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Del Zompo, M, DePaulo, JR, Étain, B, Jamain, S, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Herms, S, Hoffmann, P, Jiménez, E, Kahn, JP, Kassem, L, Kuo, PH, Kato, T, Kelsoe, JR, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, König, B, Kusumi, I, Laje, G, Landén, M, Lavebratt, C, Leckband, SG, Tortorella, A, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, SL, Colom, F, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nöthen, MM, Novák, T, O’Donovan, C, Ozaki, N, Ösby, U, Pfennig, A, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Pisanu, C, Squassina, A, Le Clerc, S, Lombardi, L, Baune, BT, Amare, AT, Schubert, KO, Hou, L, Clark, SR, Papiol, S, Cearns, M, Heilbronner, U, Degenhardt, F, Tekola-Ayele, F, Hsu, YH, Shekhtman, T, Adli, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Brichant-Petitjean, C, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Cruceanu, C, Czerski, PM, Dalkner, N, Dayer, A, Del Zompo, M, DePaulo, JR, Étain, B, Jamain, S, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Fullerton, JM, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Grof, P, Hashimoto, R, Hauser, J, Herms, S, Hoffmann, P, Jiménez, E, Kahn, JP, Kassem, L, Kuo, PH, Kato, T, Kelsoe, JR, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, König, B, Kusumi, I, Laje, G, Landén, M, Lavebratt, C, Leckband, SG, Tortorella, A, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, SL, Colom, F, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nöthen, MM, Novák, T, O’Donovan, C, Ozaki, N, Ösby, U, Pfennig, A, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Pisanu, C, and Squassina, A
Abstract: Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li (p < 1 × 10−3; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response.
Published: 2021

50. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Author: Sønderby, I.E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G.B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N.J., Bernard, M., Blackburn, N.B., Blangero, J., Boomsma, D.I., Brodaty, H., Brouwer, R.M., Bülow, R., Bøen, R., Cahn, W., Calhoun, V.D., Caspers, S., Ching, C.R.K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J.E., Dale, A.M., Dalvie, S., Dazzan, P., de Geus, E.J.C., de Zubicaray, G.I., de Zwarte, S.M.C., Desrivières, S., Doherty, J.L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S.E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Ge, T., Glahn, D.C., Grabe, H.J., Groenewold, N.A., Gústafsson, Ó., Haavik, J., Håberg, A.K., Hall, J., Hashimoto, R., Hehir-Kwa, J.Y., Hibar, D.P., Hillegers, M.H.J., Hoffmann, P., Holleran, L., Holmes, A.J., Homuth, G., Hottenga, J-J, Hulshoff Pol, H.E., Ikeda, M., Jahanshad, N., Jockwitz, C., Johansson, S., Jönsson, E.G., Jørgensen, N.R., Kikuchi, M., Knowles, E.E.M., Kumar, K., Le Hellard, S., Leu, C., Linden, D.E.J., Liu, J., Lundervold, A., Lundervold, A.J., Maillard, A.M., Martin, N.G., Martin-Brevet, S., Mather, K.A., Mathias, S.R., McMahon, K.L., McRae, A.F., Medland, S.E., Meyer-Lindenberg, A., Moberget, T., Modenato, C., Sánchez, J.M., Morris, D.W., Mühleisen, T.W., Murray, R.M., Nielsen, J., Nordvik, J.E., Nyberg, L., Loohuis, L.M.O., Ophoff, R.A., Owen, M.J., Paus, T., Pausova, Z., Peralta, J.M., Pike, G.B., Prieto, C., Quinlan, E.B., Reinbold, C.S., Marques, T.R., Rucker, J.J.H., Sachdev, P.S., Sando, S.B., Schofield, P.R., Schork, A.J., Schumann, G., Shin, J., Shumskaya, E., Silva, A.I., Sisodiya, S.M., Steen, V.M., Stein, D.J., Strike, L.T., Suzuki, I.K., Tamnes, C.K., Teumer, A., Thalamuthu, A., Tordesillas-Gutierrez, D., Uhlmann, A., Ulfarsson, M.O., van ‘t Ent, D., van den Bree, M.B.M., Vanderhaeghen, P., Vassos, E., Wen, W., Wittfeld, K., Wright, M.J., Agartz, I., Djurovic, S., Westlye, L.T., Stefánsson, H., Stefánsson, K., Jacquemont, S., Thompson, P.M., Andreassen, O.A., Sønderby, I.E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G.B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N.J., Bernard, M., Blackburn, N.B., Blangero, J., Boomsma, D.I., Brodaty, H., Brouwer, R.M., Bülow, R., Bøen, R., Cahn, W., Calhoun, V.D., Caspers, S., Ching, C.R.K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J.E., Dale, A.M., Dalvie, S., Dazzan, P., de Geus, E.J.C., de Zubicaray, G.I., de Zwarte, S.M.C., Desrivières, S., Doherty, J.L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S.E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Ge, T., Glahn, D.C., Grabe, H.J., Groenewold, N.A., Gústafsson, Ó., Haavik, J., Håberg, A.K., Hall, J., Hashimoto, R., Hehir-Kwa, J.Y., Hibar, D.P., Hillegers, M.H.J., Hoffmann, P., Holleran, L., Holmes, A.J., Homuth, G., Hottenga, J-J, Hulshoff Pol, H.E., Ikeda, M., Jahanshad, N., Jockwitz, C., Johansson, S., Jönsson, E.G., Jørgensen, N.R., Kikuchi, M., Knowles, E.E.M., Kumar, K., Le Hellard, S., Leu, C., Linden, D.E.J., Liu, J., Lundervold, A., Lundervold, A.J., Maillard, A.M., Martin, N.G., Martin-Brevet, S., Mather, K.A., Mathias, S.R., McMahon, K.L., McRae, A.F., Medland, S.E., Meyer-Lindenberg, A., Moberget, T., Modenato, C., Sánchez, J.M., Morris, D.W., Mühleisen, T.W., Murray, R.M., Nielsen, J., Nordvik, J.E., Nyberg, L., Loohuis, L.M.O., Ophoff, R.A., Owen, M.J., Paus, T., Pausova, Z., Peralta, J.M., Pike, G.B., Prieto, C., Quinlan, E.B., Reinbold, C.S., Marques, T.R., Rucker, J.J.H., Sachdev, P.S., Sando, S.B., Schofield, P.R., Schork, A.J., Schumann, G., Shin, J., Shumskaya, E., Silva, A.I., Sisodiya, S.M., Steen, V.M., Stein, D.J., Strike, L.T., Suzuki, I.K., Tamnes, C.K., Teumer, A., Thalamuthu, A., Tordesillas-Gutierrez, D., Uhlmann, A., Ulfarsson, M.O., van ‘t Ent, D., van den Bree, M.B.M., Vanderhaeghen, P., Vassos, E., Wen, W., Wittfeld, K., Wright, M.J., Agartz, I., Djurovic, S., Westlye, L.T., Stefánsson, H., Stefánsson, K., Jacquemont, S., Thompson, P.M., and Andreassen, O.A.
Abstract: Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive dosage effects of copy number on intracranial volume (ICV) and total cortical surface area, with the largest effects in frontal and cingulate cortices, and negative dosage effects on caudate and hippocampal volumes. The carriers displayed distinct cognitive deficit profiles in cognitive tasks from the UK Biobank with intermediate decreases in duplication carriers and somewhat larger in deletion carriers—the latter potentially mediated by ICV or cortical surface area. These results shed light on pathobiological mechanisms of neurodevelopmental disorders, by demonstrating gene dose effect on specific brain structures and effect on cognitive function.
Published: 2021

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