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1. Modulation of atrazine-induced chromosomal aberrations and cyclin-dependent kinases by aqueous extract of Roylea cinerea (D.Don) Baillon leaves in Allium cepa

Author

Farhana Rashid, Davinder Singh, Shivani Attri, Prabhjot Kaur, Harneetpal Kaur, Pallvi Mohana, Jahangeer Quadar, Adarsh Pal Vig, Astha Bhatia, Balbir Singh, Harpreet Walia, and Saroj Arora

Subjects
Medicine, Science
Abstract

Abstract Roylea cinerea (D.Don) Baillon an indigenous medicinal plant of Lamiaceae family used for the treatment of several diseases. In the present study, its aqueous (leaves) extract was tested for genoprotective action against atrazine-induced chromosomal aberrations in the root tip cells of Allium cepa. Atrazine is a herbicide of triazine class commonly used to inhibit the growth of broad leaf and grassy weeds. In order to find the concentration of atrazine that exhibits maximum toxicity, its different concentrations (1, 5 and 10 µg/mL) were tested. It was observed that 10 µg/mL concentration was more toxic as it reduced the mitotic index and also increased the chromosomal aberrations. Among all the tested concentrations of aqueous (leaves) extracts (0.25. 0.5, 1.0, 1.5 and 3.0 µg/mL), the3.0 µg/mL concentration in both modes of experiments i.e. pre and post showed a significant reduction in chromosomal aberrations induced by atrazine. To understand the mechanism of protection by plant extract on atrazine-induced chromosomal abnormalities the RT-qPCR studies were conducted to observe the expression of marker genes Cyclin-dependent kinases (CDKs) (CDKA:1, CDKB2:1 and CDKD1:1. For this, the RNA was extracted from root tips treated with extract along with atrazine by TRIzol®. It was observed that aqueous extract of Roylea cinerea (D.Don) Baillon leaves upregulated the CDKs gene expression in both the modes i.e. pre and post treatments. A critical analysis of results indicated that aqueous extract ameliorated the chromosomal aberrations caused by atrazine which may be be due to the increased expression level of CDKs genes.

Published
2022
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2. Frankincense oil-loaded nanoemulsion formulation of paclitaxel and erucin: A synergistic combination for ameliorating drug resistance in breast cancer: In vitro and in vivo study

Author

Harneetpal Kaur, Kirandeep Kaur, Atamjit Singh, Neena Bedi, Balbir Singh, Mansour S. Alturki, Mohammed F. Aldawsari, Atiah H. Almalki, Shafiul Haque, Hae-Jeung Lee, Dharmendra K. Yadav, and Saroj Arora

Subjects
erucin, paclitaxel, synergism, frankincense oil, nanoemulsion, breast cancer, Therapeutics. Pharmacology, RM1-950
Abstract

Nanoformulation-based combinational drug delivery systems are well known to overcome drug resistance in cancer management. Among them, nanoemulsions are well-known and thermodynamically stable drug delivery systems suitable for carrying hydrophobic drugs and phytoconstituents to tackle drug-resistant cancers. In the present study, we have investigated the effect of paclitaxel in combination with erucin (natural isothiocyanate isolated from the seeds of Eruca sativa) loaded in the frankincense oil-based nanoemulsion formulation. The choice of frankincense oil for the current study was based on reported research investigations stating its magnificient therapeutic potential against breast cancer. Optimized nanoemulsion of paclitaxel (PTX) and erucin (ER) combination (EPNE) provided sustained release and exhibited enhanced cytotoxicity towards human epithelial breast cancer cells (T-47D) as compared to individual ER and PTX. EPNE was further assessed for its antitumor activity in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer mice model. EPNE significantly decreased the levels of hepatic and renal parameters along with oxidative stress in breast cancer mice. Furthermore, EPNE also showed decreased levels of inflammatory cytokines TNF-α, IL-6. Histopathological examinations revealed restoration of the tumorous breast to normal tissues in EPNE-treated breast cancer mice. Therefore, EPNE can act as a viable lead and therapeutic option for drug-resistant breast cancer.

Published
2022
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3. PERCEIVED STRESSORS DUE TO ONLINE CLASSES

Author

Kanika Kumar and Harneetpal Kaur

Subjects
General Medicine
Abstract

Aim:A study to assess the Perceived Stressors due to online classes among students selected university of Gurugram, Haryana during COVID-19 pandemic. Methodology: Non Experimental descriptive design was adopted in the present study. Non Probability snowball technique was used to select the sample size of 100students of selected university of Gurugram, Haryana. Result:56% feels isolated during online classes.75% are worried about their network fluctuations during online classes.66% feels doubtful regarding the knowledge that has been imparted through online education.79% claims that they suffer from Mental Exhaustion.66% feels that they are doing things because they have to not because they want it. 73% are afraid & concerned about their future jobs. While 84% suffers from eyestrain & 71% are experiencing headaches.71% agreed to the fact that they become irritable/ grouchy due to online schedule. On the other hand 73% feels that network fluctuations hinder their ability to learn more. Conclusions: The findings of the study depicts that most of the students had stress due to online classes during Covid 19- pandemic.

Published
2022

4. PERCEIVED STRESSORS DUE TO ONLINE CLASSES

Author

Kanika Kumar and Harneetpal Kaur

Abstract

Aim:A study to assess the Perceived Stressors due to online classes among students selected university of Gurugram, Haryana during COVID-19 pandemic. Methodology: Non Experimental descriptive design was adopted in the present study. Non Probability snowball technique was used to select the sample size of 100students of selected university of Gurugram, Haryana. Result:56% feels isolated during online classes.75% are worried about their network fluctuations during online classes.66% feels doubtful regarding the knowledge that has been imparted through online education.79% claims that they suffer from Mental Exhaustion.66% feels that they are doing things because they have to not because they want it. 73% are afraid & concerned about their future jobs. While 84% suffers from eyestrain & 71% are experiencing headaches.71% agreed to the fact that they become irritable/ grouchy due to online schedule. On the other hand 73% feels that network fluctuations hinder their ability to learn more. Conclusions:The findings of the study depicts that most of the students had stress due to online classes during Covid 19- pandemic.

Published
2022
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5. A DESCRIPTIVE STUDY TO ASSESS THE QUALITY OF LIFE AND COPING STRATEGIES ADOPTED BY PULMONARY TUBERCULOSIS PATIENTS AT SELECTED DOTS CENTERS WITH A VIEW TO DEVELOP A PAMPHLET

Author

Rashmi and Harneetpal Kaur.

Subjects
International Journal of Advanced Research (IJAR)
Abstract

The study aimed to identify the quality of life and coping strategies adopted by Pulmonary Tuberculosis patients. The research design adopted for the study was descriptive survey design in which 100 Pulmonary Tuberculosis patients were taken atPataudi, DOTS centre of District Gurugram. The tools used for data collection was structured WHOQOL rating scale to assess the quality of life and Moo?s coping rating scale to assess the coping strategies adopted by pulmonary tuberculosis patients. A final study was conducted in the month of December of 2018 and the data was collected by using interview technique. The data obtained were analyzed using descriptive statistics.

Published
2019
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6. Plant-Based Polysaccharides and their Health Functions

Author

Palvi Sharma, Astha Bhatia, Shivani Attri, Harneetpal Kaur, Avinash Kumar, Balbir Singh, Saroj Arora, Davinder Singh, Sharabjit Singh, Ankita Rajput, Harpal S. Buttar, and Prabhjot Kaur

Subjects
chemistry.chemical_classification, Nutrition and Dietetics, business.industry, media_common.quotation_subject, Natural polymers, Medicine (miscellaneous), Plant based, Biology, Polysaccharide, Biochemistry, Cosmetics, Biotechnology, Cell wall, Nutraceutical, chemistry, Drug delivery, business, Glycosamine, Food Science, media_common
Abstract

Plants are valuable source of polysaccharides that make a large portion of our daily diet. These are natural polymers that are essential to sustain life. They provide high-value nutrition and positively help the immune system and improve the digestive properties. They also help in the elimination of toxic by-products from the human body. Polysaccharides and human health are inextricably linked and intertwined. These are also important components of the cell wall that provides its strength and integrity. Due to their indispensable role in human health, it is very important to know the different modifications and loss of nutritional value during the processing of plant material. Nowadays, these plant-based polysaccharides are used for diverse applications including wound dressing, drug delivery, laxative, cosmetic and pharmaceutical preparations. As an emerging area of plant-based medicines to reduce the side effects of synthetic sources, these polysaccharides are used to enhance the immunogenic response against a specific antigen. This review envisages some important polysaccharides (e.g. mucilages and gums, glycosamine glycans and chitin/chitosan) and their medical, cosmetic, and pharmaceutical applications, with emphasis on the relationship between their structure and function.Keywords: Polysaccharides; Nutrition; Health Functions; Cosmetics; Vaccine; Nutraceuticals

Published
2021

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