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Your search keyword '"Hanazono, Kiwamu"' showing total 23 results
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23 results on '"Hanazono, Kiwamu"'

14. Mandibular vascular hamartoma in a cat

Author

TAKAGI, Satoshi, primary, KAGAWA, Yumiko, additional, HANAZONO, Kiwamu, additional, MURAKAMI, Shoko, additional, DEGUCHI, Tatsuya, additional, IZUMI, Yusuke, additional, HOSOYA, Kenji, additional, KIM, Sangho, additional, and OKUMURA, Masahiro, additional

Published
2018
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22. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder.

Author

Nishimori T, Hanazono K, Matsuda K, Kawamura Y, Kadosawa T, Endo Y, and Uchide T

Subjects
Animals, Dogs, Female, Humans, Male, Prognosis, Urinary Bladder, Carcinoma, Transitional Cell veterinary, Cystitis metabolism, Cystitis veterinary, Dog Diseases diagnosis, Dog Diseases metabolism, Urinary Bladder Neoplasms veterinary
Abstract

Background: Decreased p63 protein expression in canine transitional cell carcinoma (TCC) of the urinary bladder is associated with vascular invasion of the tumor, metastasis, and shortened survival. ΔNp63, an isoform of p63, is downregulated in high-grade invasive urothelial carcinoma in humans. However, the clinical significance of ΔNp63 expression in canine urinary bladder tumors is unknown. Therefore, it is essential to investigate ΔNp63 expression patterns in TCC, the most common urinary bladder tumor in dogs., Aim: This study aimed to evaluate the expression and role of ΔNp63 in canine TCC of the urinary bladder., Methods: ΔNp63 expression was compared between the normal canine urinary bladder, polypoid cystitis, and TCC. The correlation of ΔNp63 expression with histopathological and clinical findings were further evaluated, and its usefulness as a prognostic factor was examined., Results: We observed that ΔNp63 was highly expressed in dogs' normal urinary bladder and polypoid cystitis, and its expression levels were low in TCC. Furthermore, low levels of ΔNp63 expression were associated with vascular invasion, metastasis, and shortened survival in dogs with TCC., Conclusion: These results indicate that ΔNp63 expression could serve as a valuable biomarker for invasion, metastasis, and prognosis of canine TCC of the urinary bladder., Competing Interests: The authors declare that there are no conflicts of interest.

Published
2021
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23. Effects of immunosuppressive prednisolone therapy on pancreatic tissue and concentration of canine pancreatic lipase immunoreactivity in healthy dogs.

Author

Ohta H, Kojima K, Yokoyama N, Sasaki N, Kagawa Y, Hanazono K, Ishizuka T, Morishita K, Nakamura K, Takagi S, and Takiguchi M

Subjects
Animals, Gene Expression Regulation, Enzymologic drug effects, Lipase immunology, Lipase metabolism, Dogs metabolism, Immunosuppressive Agents pharmacology, Lipase blood, Pancreas drug effects, Pancreas enzymology, Prednisolone pharmacology
Abstract

The objective of this study was to examine the effects of immunosuppressive prednisolone therapy on pancreatic tissue and the concentration of serum canine pancreatic lipase immunoreactivity (cPLI) in healthy dogs. Six healthy beagle dogs were subcutaneously administered an immunosuppressive dose of prednisolone [4 mg/kg body weight (BW)] once daily for either 2 or 3 weeks. Serum cPLI concentration was measured before and after treatment. Ultrasonographic examination of the pancreas and laparoscopic biopsy and histopathological examination of the right pancreatic lobe and the liver were also conducted before and after treatment. The expression of pancreatic lipase messenger ribonucleic acid (mRNA) in the pancreas and liver was examined by polymerase chain reaction (PCR). Although the serum cPLI concentration was significantly higher on day 14 and on the day of the second laparoscopy than before treatment, it was classified as normal (≤ 200 μg/L) in 5 dogs and as abnormal (≥ 400 μg/L) in only 1 dog. None of the 6 dogs showed clinical signs of pancreatitis during the study period. After treatment, ultrasonographic examination of the pancreas showed no changes except for a hypoechoic pancreas in 1 dog. Histopathological examination of the right pancreatic lobe in all dogs showed no evidence of pancreatitis after treatment. Pancreatic lipase mRNA expression was detected in the pancreas, but not in the liver, before and after treatment. The administration of 4 mg/kg BW per day of prednisolone for 2 or 3 weeks increased the serum cPLI concentration without clinical signs of pancreatitis, although an abnormal cPLI concentration (≥ 400 μg/L) was observed in only 1 dog. No ultrasonographic or histological evidence of pancreatitis was observed in any of the dogs.

Published
2018

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