Search

Your search keyword '"Hanaoka, Kazuo"' showing total 319 results
Start Over Author "Hanaoka, Kazuo" Search Limiters Full Text
319 results on '"Hanaoka, Kazuo"'

1. Single-Nucleotide Polymorphisms of the PAR2 and IL-17A Genes Are Significantly Associated with Chronic Pain.

Author

Soeda, Moe, Ohka, Seii, Nishizawa, Daisuke, Iseki, Masako, Yamaguchi, Keisuke, Arita, Hideko, Hanaoka, Kazuo, Kato, Jitsu, Ogawa, Setsuro, Hiranuma, Ayako, Hasegawa, Junko, Nakayama, Kyoko, Ebata, Yuko, Hayashida, Masakazu, Ichinohe, Tatsuya, Fukuda, Ken-ichi, and Ikeda, Kazutaka

Subjects
SINGLE nucleotide polymorphisms, CHRONIC pain, PROTEASE-activated receptors, T helper cells, GENETIC polymorphisms, AUTOIMMUNE diseases
Abstract

Patients with chronic pain are affected psychologically and socially. There are also individual differences in treatment efficacy. Insufficient research has been conducted on genetic polymorphisms that are related to individual differences in the susceptibility to chronic pain. Autoimmune disorders can lead to inflammation and chronic pain; therefore, we focused on the autoimmune-related protease-activated receptor 2 (PAR2/F2RL1) and interleukin 17A (IL-17A/IL17A) genes. PAR2 and IL-17A are associated with autoimmune diseases that lead to chronic pain, and PAR2 regulates T-helper (Th) cell activation and differentiation. We hypothesized that the PAR2 and IL-17A genes are associated with chronic pain. The present study used a case–control design to statistically examine associations between genetic polymorphisms and the vulnerability to chronic pain. The rs2243057 polymorphism of the PAR2 gene and rs3819025 polymorphism of the IL-17A gene were previously reported to be associated with pain- or autoimmune-related phenotypes. Thus, these polymorphisms were investigated in the present study. We found that both rs2243057 and rs3819025 were significantly associated with a susceptibility to chronic pain. The present findings revealed autoimmune-related genetic factors that are involved in individual differences in chronic pain, further aiding understanding of the pathomechanism that underlies chronic pain and possibly contributing to future personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

2. Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain

Author

Aoki, Yoshinori, primary, Nishizawa, Daisuke, additional, Ohka, Seii, additional, Kasai, Shinya, additional, Arita, Hideko, additional, Hanaoka, Kazuo, additional, Yajima, Choku, additional, Iseki, Masako, additional, Kato, Jitsu, additional, Ogawa, Setsuro, additional, Hiranuma, Ayako, additional, Hasegawa, Junko, additional, Nakayama, Kyoko, additional, Ebata, Yuko, additional, Ichinohe, Tatsuya, additional, Hayashida, Masakazu, additional, Fukuda, Ken-ichi, additional, and Ikeda, Kazutaka, additional

Published
2023
Full Text
View/download PDF

3. sj-pdf-1-mpx-10.1177_1744806921999924 - Supplemental material for Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia

Author

Nishizawa, Daisuke, Iseki, Masako, Arita, Hideko, Hanaoka, Kazuo, Choku Yajima, Jitsu Kato, Setsuro Ogawa, Hiranuma, Ayako, Kasai, Shinya, Hasegawa, Junko, Hayashida, Masakazu, and Ikeda, Kazutaka

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-mpx-10.1177_1744806921999924 for Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia by Daisuke Nishizawa, Masako Iseki, Hideko Arita, Kazuo Hanaoka, Choku Yajima, Jitsu Kato, Setsuro Ogawa, Ayako Hiranuma, Shinya Kasai, Junko Hasegawa, Masakazu Hayashida and Kazutaka Ikeda in Molecular Pain

Published
2021
Full Text
View/download PDF

4. Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia

Author

Nishizawa, Daisuke, primary, Iseki, Masako, additional, Arita, Hideko, additional, Hanaoka, Kazuo, additional, Yajima, Choku, additional, Kato, Jitsu, additional, Ogawa, Setsuro, additional, Hiranuma, Ayako, additional, Kasai, Shinya, additional, Hasegawa, Junko, additional, Hayashida, Masakazu, additional, and Ikeda, Kazutaka, additional

Published
2021
Full Text
View/download PDF

5. Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus–mediated fusogenic activity

Author

Ohka, Seii, primary, Yamada, Souichi, additional, Nishizawa, Daisuke, additional, Fukui, Yoshiko, additional, Arita, Hideko, additional, Hanaoka, Kazuo, additional, Iseki, Masako, additional, Kato, Jitsu, additional, Ogawa, Setsuro, additional, Hiranuma, Ayako, additional, Kasai, Shinya, additional, Hasegawa, Junko, additional, Hayashida, Masakazu, additional, Fukushi, Shuetsu, additional, Saijo, Masayuki, additional, and Ikeda, and Kazutaka, additional

Published
2021
Full Text
View/download PDF

9. Serological Diagnosis of Idiopathic Pulmonary Alveolar Proteinosis

Author

KITAMURA, TAKAYUKI, UCHIDA, KANJI, TANAKA, NAOHIKO, TSUCHIYA, TOMOKO, WATANABE, JUNICHI, YAMADA, YOSHITSUGU, HANAOKA, KAZUO, SEYMOUR, JOHN F., SCHOCH, OTTO D., DOYLE, IAN, INOUE, YOSHIKAZU, SAKATANI, MITSUNORI, KUDOH, SHOJI, AZUMA, ARATA, NUKIWA, TOSHIHIRO, TOMITA, TOMOYUKI, KATAGIRI, MAKOTO, FUJITA, AKIRA, KURASHIMA, ATSUYUKI, KANEGASAKI, SHIRO, and NAKATA, KOH

Published
2000
Full Text
View/download PDF

13. Washed cell salvage in surgical patients : a review and meta-analysis of prospective randomized trials under PRISMA

Author

Hanaoka, Kazuo, Meybohm, Patrick, Choorapoikayil, Suma, Wessels, Anke, Herrmann, Eva, Zacharowski, Kai, Spahn, Donat Rudolf, Hanaoka, Kazuo, Meybohm, Patrick, Choorapoikayil, Suma, Wessels, Anke, Herrmann, Eva, Zacharowski, Kai, and Spahn, Donat Rudolf

Abstract

Background: Cell salvage is commonly used as part of a blood conservation strategy. However concerns among clinicians exist about the efficacy of transfusion of washed cell salvage. Methods: We performed a meta-analysis of randomized controlled trials in which patients, scheduled for all types of surgery, were randomized to washed cell salvage or to a control group with no cell salvage. Data were independently extracted, risk ratio (RR), and weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Data were pooled using a random effects model. The primary endpoint was the number of patients exposed to allogeneic red blood cell (RBC) transfusion. Results: Out of 1140 search results, a total of 47 trials were included. Overall, the use of washed cell salvage reduced the rate of exposure to allogeneic RBC transfusion by a relative 39% (RR = 0.61; 95% CI 0.57 to 0.65; P < 0.001), resulting in an average saving of 0.20 units of allogeneic RBC per patient (weighted mean differences [WMD] = -0.20; 95% CI -0.22 to -0.18; P < 0.001), reduced risk of infection by 28% (RR = 0.72; 95% CI 0.54 to 0.97; P = 0.03), reduced length of hospital stay by 2.31 days (WMD = -2.31; 95% CI -2.50 to -2.11; P < 0.001), but did not significantly affect risk of mortality (RR = 0.92; 95% CI 0.63 to 1.34; P = 0.66). No statistical difference could be observed in the number of patients exposed to re-operation, plasma, platelets, or rate of myocardial infarction and stroke. Conclusions: Washed cell salvage is efficacious in reducing the need for allogeneic RBC transfusion and risk of infection in surgery.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results