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The 5G era has brought opportunities for the rapid development of the Internet of things. Identity authentication is the basis for ensuring the security of the Internet of things. However, in the face of quantum attacks due to the large number of nodes in the Internet of things, the signcrypt-based identity authentication scheme will consume a lot of resources to generate node keys, which is difficult to meet the low cost requirements of the Internet of things. Therefore, a lightweight lattice-based group signcryption authentication scheme was designed. In the key generation stage, the improved trapdoor diagonal matrix was designed to optimize the original image sampling algorithm required for key generation and reduce the overall time required for generating a large number of keys. In the identity authentication stage, based on the residual Hash lemma and the signcryptic property, the message was signed and encrypted in one logical step at the same time, and the interaction flow of dot multiplication and Hash operation with low frequency was proposed to complete the access authentication performed by the group leader on behalf of the group members. Simulation experiments show that this scheme reduces the number of interactions during the access of Internet of things devices, reduces the computing cost of identity authentication stage, and reduces the total cost of signcryption and decryption by more than 7% compared with the existing schemes. Furthermore, the simulation results prove that this scheme can resist quantum attacks in the Internet of things.

Early rehabilitation is crucial in reducing stroke-related disability, but the optimal training model remains unclear. We conducted a trial comparing different initiation timings and intensities of mobilization strategies after stroke. Results showed that early intensive mobilization had favorable outcomes at 3 months post-stroke, while very early intensive mobilization had poorer chances of favorable outcomes. Our investigation into brain injury mechanisms induced by very early exercise within 24 hours of stroke onset aligned with guidelines advising against high-dose very early mobilization. Additionally, we are studying the effects of various exercise intensities and frequencies on early stroke rehabilitation. Integrated rehabilitation models, such as combining remote ischemic conditioning (RIC) with exercise (RICE), hold promise. Our study found RICE to be safe and feasible for early rehabilitation of acute ischemic stroke patients, and further research is underway to determine its efficacy in a larger sample size. Despite extensive research, identifying the most effective early recovery strategies remains a complex challenge, necessitating ongoing work in the field of early rehabilitation after stroke. [ABSTRACT FROM AUTHOR]

Background: Brain inflammation plays a key role in ischemia/reperfusion (I/R) injury and is the main cause of "ineffective or futile recanalization" after successful mechanical thrombectomy (MT) in acute ischemic stroke (AIS). One of the primary sources of inflammatory cells after AIS are derived from the spleen. As an innovative and potential neuroprotective strategy after stroke, Remote Administration of Hypothermia (RAH) temporarily suppresses immune activities in the spleen, reduces the release of inflammatory cells and cytokines into blood, and thus reversibly diminishes inflammatory injury in the brain., Methods: This single-center, prospective, randomized controlled study (RCT) is proposed for AIS patients with anterior circulation large vessel occlusion (LVO). Subjects will be randomly assigned to either the control or intervention groups in a 1:1 ratio ( n  = 40). Participants allocated to the intervention group will receive RAH on the abdomen above the spleen prior to recanalization until 6 h after thrombectomy. All enrolled patients will receive standard stroke Guideline care. The main adverse events associated with RAH are focal cold intolerance and abdominal pain. The primary outcome will assess safety as it pertains to RAH application. The secondary outcomes include the efficacy of RAH on spleen, determined by spleen volumes, blood inflammatory factor (cells and cytokines), and on brain injury, determined by infarction volumes and poststroke functional outcomes., Discussion: This study aims to examine the safety and preliminary effectiveness of RAH over the spleen during endovascular therapy in AIS patients. The results of this study are expected to facilitate larger randomized clinical trials and hopefully prove RAH administration confers adjuvant neuroprotective properties in AIS treated with MT., Clinical Trial Registration: https://www.chictr.org.cn/. Identifier ChiCTR 2300077052., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Duan, Cheng, Geng, Rajah, Gao, Guo, Cai, Tong, Li, Jiang, Han and Ding.)

Stroke remains a leading cause of adult death and disability. Poststroke rehabilitation is vital for reducing the long-term sequelae of brain ischemia. Recently, physical exercise training has been well established as an effective rehabilitation tool, but its efficacy depends on exercise parameters and the patient's capacities, which are often altered following a major cerebrovascular event. Thus, ischemic conditioning as a rehabilitation intervention was considered an "exercise equivalent," but the investigation is still in its relative infancy. In this mini-review, we discuss the potential for physical exercise or ischemic conditioning and its relation to angiogenesis, neurogenesis, and plasticity in stroke rehabilitation. This allows the readers to understand the context of the research and the application of ischemic conditioning in poststroke rehabilitation., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Brain Circulation.)

A SeO 2 ethanol solution as the facile precursor has been used for the preparation of quaternary Cu 2 ZnSnSe 4 (CZTSe) nanoplates. Monodispersed single-phase CZTSe nanoplates have been prepared successfully by a facile one-pot thermal chemical method. The as-prepared CZTSe nanoplates show uniform morphology with a bandgap of ~ 1.4 eV. As a proof of concept, the CZTSe nanoplates have been used as a visible-light-driven photocatalyst for Rhodamine B dye degradation and show high photocatalytic activity and stability. The excellent dye removal is mainly ascribed to the efficient light utilization of CZTSe nanoplates.