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2. Standards recommendations for the Earth BioGenome Project

Author

Lawniczak, Mara KN, Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M, Baker, William J, Belov, Katherine, Blaxter, Mark L, Bonet, Tomas Marques, Childers, Anna K, Coddington, Jonathan A, Crandall, Keith A, Crawford, Andrew J, Davey, Robert P, Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina J, Howe, Kerstin, Jarvis, Erich D, Johnson, Warren E, Johnson, Rebecca N, Kersey, Paul J, Liu, Xin, Lopez, Jose Victor, Myers, Eugene W, Pettersson, Olga Vinnere, Phillippy, Adam M, Poelchau, Monica F, Pruitt, Kim D, Rhie, Arang, Castilla-Rubio, Juan Carlos, Sahu, Sunil Kumar, Salmon, Nicholas A, Soltis, Pamela S, Swarbreck, David, Thibaud-Nissen, Françoise, Wang, Sibo, Wegrzyn, Jill L, Zhang, Guojie, Zhang, He, Lewin, Harris A, and Richards, Stephen

Subjects
Human Genome, Genetics, Animals, Base Sequence, Biodiversity, Eukaryota, Genomics, Humans, Reference Standards, Reference Values, Sequence Analysis, DNA, Earth BioGenome Project, genomics, ethics, genome assembly
Abstract

A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.

Published
2022

3. Why sequence all eukaryotes?

Author

Blaxter, Mark, Archibald, John M, Childers, Anna K, Coddington, Jonathan A, Crandall, Keith A, Di Palma, Federica, Durbin, Richard, Edwards, Scott V, Graves, Jennifer AM, Hackett, Kevin J, Hall, Neil, Jarvis, Erich D, Johnson, Rebecca N, Karlsson, Elinor K, Kress, W John, Kuraku, Shigehiro, Lawniczak, Mara KN, Lindblad-Toh, Kerstin, Lopez, Jose V, Moran, Nancy A, Robinson, Gene E, Ryder, Oliver A, Shapiro, Beth, Soltis, Pamela S, Warnow, Tandy, Zhang, Guojie, and Lewin, Harris A

Subjects
Biotechnology, Animals, Base Sequence, Biodiversity, Biological Evolution, Ecology, Ecosystem, Eukaryota, Genome, Genomics, Humans, Phylogeny, genome, diversity, ecology, evolution, conservation
Abstract

Life on Earth has evolved from initial simplicity to the astounding complexity we experience today. Bacteria and archaea have largely excelled in metabolic diversification, but eukaryotes additionally display abundant morphological innovation. How have these innovations come about and what constraints are there on the origins of novelty and the continuing maintenance of biodiversity on Earth? The history of life and the code for the working parts of cells and systems are written in the genome. The Earth BioGenome Project has proposed that the genomes of all extant, named eukaryotes-about 2 million species-should be sequenced to high quality to produce a digital library of life on Earth, beginning with strategic phylogenetic, ecological, and high-impact priorities. Here we discuss why we should sequence all eukaryotic species, not just a representative few scattered across the many branches of the tree of life. We suggest that many questions of evolutionary and ecological significance will only be addressable when whole-genome data representing divergences at all of the branchings in the tree of life or all species in natural ecosystems are available. We envisage that a genomic tree of life will foster understanding of the ongoing processes of speciation, adaptation, and organismal dependencies within entire ecosystems. These explorations will resolve long-standing problems in phylogenetics, evolution, ecology, conservation, agriculture, bioindustry, and medicine.

Published
2022

5. Comparative genomic analysis of the 'pseudofungus' Hyphochytrium catenoides.

Author

Leonard, Guy, Labarre, Aurélie, Milner, David S, Monier, Adam, Soanes, Darren, Wideman, Jeremy G, Maguire, Finlay, Stevens, Sam, Sain, Divya, Grau-Bové, Xavier, Sebé-Pedrós, Arnau, Stajich, Jason E, Paszkiewicz, Konrad, Brown, Matthew W, Hall, Neil, Wickstead, Bill, and Richards, Thomas A

Subjects
Animals, Rhinosporidium, Phylogeny, Genome, Molecular Sequence Annotation, Whole Genome Sequencing, large DNA virus, oomycete parasitic traits, polarized filamentous growth, secondary plastid endosymbiosis, Biotechnology, Infectious Diseases, Human Genome, Genetics, Biochemistry and Cell Biology, Microbiology, Immunology
Abstract

Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. The Fungi successfully coupled osmotrophy with filamentous growth, and similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete 'pseudofungus'; Hyphochytrium catenoides Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics, demonstrating that many of the genetic features associated with parasitic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.

Published
2018

6. An investigation into phosphoric iron production in Eastern England

Author

Hall, Neil Stewart

Subjects
669, DA Great Britain, HD Industries. Land use. Labor, TN Mining engineering. Metallurgy, TS Manufactures
Abstract

Looking at iron slags from Eastern England, this thesis was designed to assess the possibility of inferring the ore type in use by the chemical composition of the slag. A number of case studies are examined. The first is a group of material from the Foulness Valley, East Yorkshire, which is known to be produced from high phosphorus bog ore. This allows direct comparison between this and other assemblages, based on phosphorus content, to infer if bog or bedded ore was in use. Assemblages from Iron Age East Yorkshire, Roman Caistor St Edmund and the Saxon sites of Quarrington and Flixboroughwere examined to infer on ore exploitation and possible metal production. The background examination provides a definition of phosphoric iron based upon its material properties and the parameters which govern the creation of the alloy. Further discussion of ore exploitation and the reasoning behind why smelting sites are more difficult to locate are covered, while the current direction of research is examined. The body of experimental work is discussed with notable case studies drawn upon to demonstrate where the literature concentrates its focus. This allows for the suggestion of future possibilities based upon the impacts of these works. An experimental smelt was carried out in order to inform on the processes and record observations which helped to dictate the choices made on raw material selection. The experimental material was analysed alongside archaeological slags produced from the same ore, and treated in the same way as the material used in the archaeological case studies. The selection criteria applied to the archaeological assemblages, based on morphology and perceived mass are outlined. A description of the preparation methods for sample examination follows. The physics of electron microscopy are then discussed covering the various effects which govern the generation of the characteristic x-rays which are responsible for the chemical composition data. Each of the case study assemblages are dealt with individually presenting photographs of the pieces before sampling and backscattered electron images of the material. As this is the first scientific analysis conducted upon the Saxon assemblages from Quarrington and Flixborough, the data generated provides critical, new insight into Early Medieval iron production. The data using phase composition and phosphorus content are presented on a site by site basis before being assembled into an overall synthesis which further clarifies the inferences of different ore exploitation. Further comparisons of phosphorus and sulphur content are used to demonstrate the use of the bog ore and Frodingham Ironstone available at Flixborough. The interpretation of the data is then drawn upon for final conclusions and inferences of ore exploitation and the identification of ironstone use at Flixborough which further supports the archaeological and historical evidence for this practice from the 7th century A.D.

Published
2017

7. Single cell ecology

Author

Richards, Thomas A., Massana, Ramon, Pagliara, Stefano, and Hall, Neil

Published
2019

8. Transcriptional analysis of Rhazya stricta in response to jasmonic acid

Author

Hajrah, Nahid H., Rabah, Samar O., Alghamdi, Mohammed K., Atef, Ahmed, Edris, Sherif, Alhebshi, Alawiah M., Hassan, Sabah M., Alzahrani, Dhafer A., Bahieldin, Ahmed, Mutwakil, Mohammed H.Z., Alqurashi, Yaser E., Al-Zahrani, Hassan S., Abo-Aba, Salah E.M., Jansen, Robert K., Sabir, Jamal S.M., Hall, Neil, and Kamli, Majid Rasool

Published
2021
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10. Identification of a non-canonical ciliate nuclear genetic code where UAA and UAG code for different amino acids

Author

McGowan, Jamie, primary, Kilias, Estelle S., additional, Alacid, Elisabet, additional, Lipscombe, James, additional, Jenkins, Benjamin H., additional, Gharbi, Karim, additional, Kaithakottil, Gemy G., additional, Macaulay, Iain C., additional, McTaggart, Seanna, additional, Warring, Sally D., additional, Richards, Thomas A., additional, Hall, Neil, additional, and Swarbreck, David, additional

Published
2023
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11. A haplotype map of allohexaploid wheat reveals distinct patterns of selection on homoeologous genomes

Author

Jordan, Katherine W, Wang, Shichen, Lun, Yanni, Gardiner, Laura-Jayne, MacLachlan, Ron, Hucl, Pierre, Wiebe, Krysta, Wong, Debbie, Forrest, Kerrie L, IWGS Consortium, Sharpe, Andrew G, Sidebottom, Christine HD, Hall, Neil, Toomajian, Christopher, Close, Timothy, Dubcovsky, Jorge, Akhunova, Alina, Talbert, Luther, Bansal, Urmil K, Bariana, Harbans S, Hayden, Matthew J, Pozniak, Curtis, Jeddeloh, Jeffrey A, Hall, Anthony, and Akhunov, Eduard

Subjects
Biological Sciences, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Chromosome Mapping, Chromosomes, Plant, Exome, Gene Frequency, Genome, Plant, Genotype, Haplotypes, Polymorphism, Single Nucleotide, Polyploidy, Selection, Genetic, Triticum, IWGS Consortium, Environmental Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundBread wheat is an allopolyploid species with a large, highly repetitive genome. To investigate the impact of selection on variants distributed among homoeologous wheat genomes and to build a foundation for understanding genotype-phenotype relationships, we performed population-scale re-sequencing of a diverse panel of wheat lines.ResultsA sample of 62 diverse lines was re-sequenced using the whole exome capture and genotyping-by-sequencing approaches. We describe the allele frequency, functional significance, and chromosomal distribution of 1.57 million single nucleotide polymorphisms and 161,719 small indels. Our results suggest that duplicated homoeologous genes are under purifying selection. We find contrasting patterns of variation and inter-variant associations among wheat genomes; this, in addition to demographic factors, could be explained by differences in the effect of directional selection on duplicated homoeologs. Only a small fraction of the homoeologous regions harboring selected variants overlapped among the wheat genomes in any given wheat line. These selected regions are enriched for loci associated with agronomic traits detected in genome-wide association studies.ConclusionsEvidence suggests that directional selection in allopolyploids rarely acted on multiple parallel advantageous mutations across homoeologous regions, likely indicating that a fitness benefit could be obtained by a mutation at any one of the homoeologs. Additional advantageous variants in other homoelogs probably either contributed little benefit, or were unavailable in populations subjected to directional selection. We hypothesize that allopolyploidy may have increased the likelihood of beneficial allele recovery by broadening the set of possible selection targets.

Published
2015

13. Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals

Author

Li, Yan, Leveau, Aymeric, Zhao, Qiang, Feng, Qi, Lu, Hengyun, Miao, Jiashun, Xue, Zheyong, Martin, Azahara C., Wegel, Eva, Wang, Jing, Orme, Anastasia, Rey, Maria-Dolores, Karafiátová, Miroslava, Vrána, Jan, Steuernagel, Burkhard, Joynson, Ryan, Owen, Charlotte, Reed, James, Louveau, Thomas, Stephenson, Michael J., Zhang, Lei, Huang, Xuehui, Huang, Tao, Fan, Danling, Zhou, Congcong, Tian, Qilin, Li, Wenjun, Lu, Yiqi, Chen, Jiaying, Zhao, Yan, Lu, Ying, Zhu, Chuanrang, Liu, Zhenhua, Polturak, Guy, Casson, Rebecca, Hill, Lionel, Moore, Graham, Melton, Rachel, Hall, Neil, Wulff, Brande B. H., Doležel, Jaroslav, Langdon, Tim, Han, Bin, and Osbourn, Anne

Published
2021
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15. Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

Author

Initiative, International Glossina Genome, Attardo, Geoffrey M, Abila, Patrick P, Auma, Joanna E, Baumann, Aaron A, Benoit, Joshua B, Brelsfoard, Corey L, Ribeiro, José MC, Cotton, James A, Pham, Daphne QD, Darby, Alistair C, Van Den Abbeele, Jan, Denlinger, David L, Field, Linda M, Nyanjom, Steven RG, Gaunt, Michael W, Geiser, Dawn L, Gomulski, Ludvik M, Haines, Lee R, Hansen, Immo A, Jones, Jeffery W, Kibet, Caleb K, Kinyua, Johnson K, Larkin, Denis M, Lehane, Michael J, Rio, Rita VM, Macdonald, Sandy J, Macharia, Rosaline W, Malacrida, Anna R, Marco, Heather G, Marucha, Kevin K, Masiga, Daniel K, Meuti, Megan E, Mireji, Paul O, Obiero, George FO, Koekemoer, Jacobus JO, Okoro, Chinyere K, Omedo, Irene A, Osamor, Victor C, Balyeidhusa, Apollo SP, Peyton, Justin T, Price, David P, Quail, Michael A, Ramphul, Urvashi N, Rawlings, Neil D, Riehle, Michael A, Robertson, Hugh M, Sanders, Mandy J, Scott, Maxwell J, Dashti, Zahra Jalali Sefid, Snyder, Anna K, Srivastava, Tulika P, Stanley, Eleanor J, Swain, Martin T, Hughes, Daniel ST, Tarone, Aaron M, Taylor, Todd D, Telleria, Erich L, Thomas, Gavin H, Walshe, Deirdre P, Wilson, Richard K, Winzerling, Joy J, Acosta-Serrano, Alvaro, Aksoy, Serap, Arensburger, Peter, Aslett, Martin, Bateta, Rosemary, Benkahla, Alia, Berriman, Matthew, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christoffels, Alan, Falchetto, Marco, Friedrich, Markus, Fu, Shuhua, Gäde, Gerd, Githinji, George, Gregory, Richard, Hall, Neil, Harkins, Gordon, Hattori, Masahira, Hertz-Fowler, Christiane, Hide, Winston, Hu, Wanqi, Imanishi, Tadashi, Inoue, Noboru, Jonas, Mario, Kawahara, Yoshihiro, Koffi, Mathurin, Kruger, Adele, Lawson, Daniel, Lehane, Stella, Lehväslaiho, Heikki, Luiz, Thiago, Makgamathe, Mmule, Malele, Imna, Manangwa, Oliver, Manga, Lucien, and Megy, Karyn

Subjects
Vector-Borne Diseases, Genetics, Prevention, Infectious Diseases, Biotechnology, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Animals, Blood, Feeding Behavior, Female, Genes, Insect, Genome, Insect, Insect Proteins, Insect Vectors, Microbiota, Molecular Sequence Annotation, Molecular Sequence Data, Reproduction, Salivary Glands, Sensation, Sequence Analysis, DNA, Symbiosis, Trypanosoma, Trypanosomiasis, African, Tsetse Flies, Wolbachia, International Glossina Genome Initiative, General Science & Technology
Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Published
2014

19. Comparative Genomics of Trypanosomatid Parasitic Protozoa

Author

El-Sayed, Najib M., Myler, Peter J., Blandin, Gaëlle, Berriman, Matthew, Crabtree, Jonathan, Aggarwal, Gautam, Caler, Elisabet, Renauld, Hubert, Worthey, Elizabeth A., Hertz-Fowler, Christiane, Ghedin, Elodie, Peacock, Christopher, Bartholomeu, Daniella C., Haas, Brian J., Tran, Anh-Nhi, Wortman, Jennifer R., Angiuoli, Samuel, Anupama, Atashi, Badger, Jonathan, Bringaud, Frederic, Cadag, Eithon, Carlton, Jane M., Cerqueira, Gustavo C., Creasy, Todd, Delcher, Arthur L., Djikeng, Appolinaire, Embley, T. Martin, Hauser, Christopher, Ivens, Alasdair C., Kummerfeld, Sarah K., Pereira-Leal, Jose B., Nilsson, Daniel, Peterson, Jeremy, Salzberg, Steven L., Shallom, Joshua, Silva, Joana C., Sundaram, Jaideep, Westenberger, Scott, White, Owen, Melville, Sara E., Donelson, John E., Andersson, Björn, Stuart, Kenneth D., and Hall, Neil

Published
2005

20. The Genome of the African Trypanosome Trypanosoma brucei

Author

Berriman, Matthew, Ghedin, Elodie, Hertz-Fowler, Christiane, Blandin, Gaëlle, Renauld, Hubert, Bartholomeu, Daniella C., Lennard, Nicola J., Caler, Elisabet, Hamlin, Nancy E., Haas, Brian, Böhme, Ulrike, Hannick, Linda, Aslett, Martin A., Shallom, Joshua, Marcello, Lucio, Hou, Lihua, Wickstead, Bill, Arrowsmith, Claire, Atkin, Rebecca J., Barron, Andrew J., Bringaud, Frederic, Brooks, Karen, Carrington, Mark, Cherevach, Inna, Chillingworth, Tracey-Jane, Churcher, Carol, Clark, Louise N., Corton, Craig H., Cronin, Ann, Davies, Rob M., Doggett, Jonathon, Djikeng, Appolinaire, Feldblyum, Tamara, Field, Mark C., Fraser, Audrey, Goodhead, Ian, Hance, Zahra, Harper, David, Harris, Barbara R., Hauser, Heidi, Hostetler, Jessica, Ivens, Al, Jagels, Kay, Johnson, David, Johnson, Justin, Jones, Kristine, Kerhornou, Arnaud X., Koo, Hean, Larke, Natasha, Landfear, Scott, Larkin, Christopher, Leech, Vanessa, Line, Alexandra, Lord, Angela, MacLeod, Annette, Mooney, Paul J., Moule, Sharon, Morgan, Gareth W., Mungall, Karen, Norbertczak, Halina, Ormond, Doug, Pai, Grace, Peacock, Chris S., Peterson, Jeremy, Quail, Michael A., Rabbinowitsch, Ester, Rajandream, Marie-Adele, Reitter, Chris, Salzberg, Steven L., Sanders, Mandy, Schobel, Seth, Sharp, Sarah, Simmonds, Mark, Simpson, Anjana J., Tallon, Luke, Tait, Andrew, Tivey, Adrian R., Van Aken, Susan, Walker, Danielle, Wanless, David, Wang, Shiliang, White, Brian, White, Owen, Whitehead, Sally, Woodward, John, Wortman, Jennifer, Adams, Mark D., Embley, T. Martin, Gull, Keith, Ullu, Elisabetta, Barry, J. David, Fairlamb, Alan H., Opperdoes, Fred, Barrell, Barclay G., Donelson, John E., Hall, Neil, Fraser, Claire M., Melville, Sara E., and El-Sayed, Najib M.

Published
2005

21. Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes

Author

Gardner, Malcolm J., Bishop, Richard, Shah, Trushar, de Villiers, Etienne P., Carlton, Jane M., Hall, Neil, Ren, Qinghu, Paulsen, Ian T., Pain, Arnab, Berriman, Matthew, Sato, Shigeharu, Ralph, Stuart A., Mann, David J., Xiong, Zikai, Shallom, Shamira J., Weidman, Janice, Jiang, Lingxia, Lynn, Jeffery, Weaver, Bruce, Shoaibi, Azadeh, Domingo, Alexander R., Wasawo, Delia, Crabtree, Jonathan, Wortman, Jennifer R., Haas, Brian, Angiuoli, Samuel V., Creasy, Todd H., Lu, Charles, Suh, Bernard, Silva, Joana C., Utterback, Teresa R., Feldblyum, Tamara V., Pertea, Mihaela, Allen, Jonathan, Nierman, William C., Salzberg, Steven L., White, Owen R., Fitzhugh, Henry A., Morzaria, Subhash, Venter, J. Craig, Fraser, Claire M., and Nene, Vishvanath

Published
2005

22. An Ancestral Oomycete Locus Contains Late Blight Avirulence Gene Avr3a, Encoding a Protein That Is Recognized in the Host Cytoplasm

Author

Armstrong, Miles R., Whisson, Stephen C., Pritchard, Leighton, Venter, Eduard, Avrova, Anna O., Rehmany, Anne P., Böhme, Ulrike, Brooks, Karen, Cherevach, Inna, Hamlin, Nancy, White, Brian, Fraser, Audrey, Lord, Angela, Quail, Michael A., Churcher, Carol, Hall, Neil, Berriman, Matthew, Huang, Sanwen, Kamoun, Sophien, Beynon, Jim L., and Cook, R. James

Published
2005

23. A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Author

Hall, Neil, Karras, Marianna, Raine, J. Dale, Carlton, Jane M., Berriman, Matthew, Florens, Laurence, Janssen, Christoph S., Pain, Arnab, Christophides, Georges K., James, Keith, Rutherford, Kim, Harris, Barbara, Harris, David, Churcher, Carol, Quail, Michael A., Ormond, Doug, Doggett, Jon, Trueman, Holly E., Mendoza, Jacqui, Bidwell, Shelby L., Rajandream, Marie-Adele, Carucci, Daniel J., Yates, John R., Kafatos, Fotis C., Janse, Chris J., Barrell, Bart, Waters, Andrew P., and Sinden, Robert E.

Published
2005

24. An Evaluation of Computer Based Activities in an Early Intervention Program. A Report to the Early Special Education Program.

Author

Wollongong Univ., New South Wales (Australia). Dept. of Education., Elliott, Alison, and Hall, Neil

Abstract

This study investigated ways of using computer-based learning activities to complement curriculum practices in preschool programs with an early intervention component through the use of computer-based learning activities. Particular attention was given to supporting the development of young children's early mathematical skills. The study took place in a preschool center in the Illawarra region of New South Wales that served at-risk children and families in crisis. The focus of the study was on teaching methodologies and learner experiences that were likely to develop the skills necessary for successful integration into formal schooling. Participants were 11 students (6 in the experimental group and 5 in the control group) who had difficulty in using language fluently and effectively in a range of situations; were unable to persevere with tasks and activities; lacked purposefulness, imagination, and variety in play; lacked initiative; and lacked normal social skills and emotional maturity. Children in the experimental group took part in 7-12 sessions at a computer over a 6-8 week period. Total computer time ranged from 140 to 240 minutes. Paired control group subjects had access to nonmathematical computer-based activities. Findings indicated that experimental group subjects gained dramatically and significantly in mathematical skills and understanding. Appendices include the pretest and posttest, descriptions of software used in the study, and criteria for evaluating early childhood software. (RH)

Published
1990

25. BioFAIR Final Report

Author

Technopolis Group, Soranzo, Nicola, Knox, Catherine, Norman, Hannah, Andrews, Robert, Beck, Tim, Micklem, Gos, Orengo, Christine, Sansone, Susanna Assunta, Hall, Neil, and Goble, Carole

Subjects
Digital Research Infrastructure, training, life sciences, productivity, interviews, Community of Practice, capacity building, bioscience, metadata, Research Data Management, Data Stewardship, curation, bioinformatics, artificial intelligence, ELIXIR, UKRI, BioFAIR, BioCommons, open science, survey, e-infrastructure, reproducibility, FAIR
Abstract

In order to identify and address the Research Data Management needs of UK bioscience researchers, in 2020 UK Research and Innovation (UKRI) Biotechnology and Biological Science Research Council (BBSRC), UKRI Medical Research Council (MRC) and Wellcome Trust funded a 9-month study to gather evidence about the adoption of the Findable, Accessible, Interoperable, Reusable (FAIR) principles, and evaluate the feasibility and impact of the creation of a new UK Institute (tentatively called "BioFAIR") delivering a FAIR Data and Method BioCommons. This is the final report of this feasibility study and has followed the standard business case process in use by UKRI and BEIS. It has been carried out by Technopolis Group in collaboration with ELIXIR-UK (the UK Node of ELIXIR) and has involved a wide-ranging programme of desk research, stakeholder consultations (online researcher surveys and institutional interviews) and a series of deliberative discussions with groups of UKRI funders, the ELIXIR-UK All Hands workshop and the ELIXIR-UK Scientific and Industry Advisory Board. The report is underpinned by a series of analytical presentations and reports, including the results of the online survey, international comparisons and cost-benefit analysis.

Published
2023
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33. Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world

Author

Ebenezer, ThankGod Echezona, primary, Low, Ross S., additional, O'Neill, Ellis Charles, additional, Huang, Ishuo, additional, DeSimone, Antonio, additional, Farrow, Scott C., additional, Field, Robert A., additional, Ginger, Michael L., additional, Guerrero, Sergio Adrián, additional, Hammond, Michael, additional, Hampl, Vladimír, additional, Horst, Geoff, additional, Ishikawa, Takahiro, additional, Karnkowska, Anna, additional, Linton, Eric W., additional, Myler, Peter, additional, Nakazawa, Masami, additional, Cardol, Pierre, additional, Sánchez-Thomas, Rosina, additional, Saville, Barry J., additional, Shah, Mahfuzur R., additional, Simpson, Alastair G. B., additional, Sur, Aakash, additional, Suzuki, Kengo, additional, Tyler, Kevin M., additional, Zimba, Paul V., additional, Hall, Neil, additional, and Field, Mark C., additional

Published
2022
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34. UKRI-BBSRC Review of technology development in the biosciences

Author

Errington, Rachel, Collinson, Lucy, Faulds, Karen, Hall, Neil, Chue Hong, Neil P, Hoogenboom, Bart, Kaler, Jasmeet, Kemsley, Kate, de Mel, Geeth, and Woolfson, Dek

Abstract

Breakthrough technologies often create a big impact, highlighting the critical dependence of world-class transformative research and innovation on newtechnologies becoming available.In 2021, the Biotechnology and Biological Sciences Research Council (BBSRC) initiated a review of technology development in recognition of its crucial importance in the biosciences. The development of transformative technologies is integral in enabling future discoveries as it allows researchers to push the boundaries of bioscience discovery, stimulate innovation and enable better understanding of biological processes and organisms. Support for this area offers significant opportunities to work across disciplines and sectors, to improve on existing technologies and create new ones across the variety of science relevant to BBSRC’s mission.The review found strong evidence for the pervasiveness of technology development across BBSRC’s portfolio, but also identified a range of challenges impacting the bioscience community. An expert task and finish group was convened to help guide and advise BBSRC during the review process. In considering the evidence gathered from our community, 7 key recommendations that aim to support the continued expansion of technology development within the biosciences have been developed:1. To enable support of the different types and stages of technology development, BBSRC should establish a comprehensive support framework, leading to an increase in investment 2. BBSRC should consider innovation in its peer review processes and fully embed technology development as a recognised and valuable component3. BBSRC should prioritise short and long-term actions to support different training needs and career stages, with an emphasis on interdisciplinary and innovator skill sets 4. BBSRC should work with the research technical professional community to highlight their talent and promote their central role in technology development in the biosciences5. BBSRC should promote the value of diversity and team working in the biosciences and foster an open, dynamic, and inclusive system of technology development in the UK 6. BBSRC should consider mechanisms to bring together the technology development communities and facilitate interdisciplinary engagement7. BBSRC should consider opportunities to support the underpinning infrastructure required for technology development

Published
2022

36. Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva

Author

Pain, Arnab, Renauld, Hubert, Berriman, Matthew, Murphy, Lee, Yeats, Corin A., Weir, William, Kerhornou, Arnaud, Aslett, Martin, Bishop, Richard, Bouchier, Christiane, Cochet, Madeleine, Cronin, Ann, de Villiers, Etienne P., Fraser, Audrey, Fosker, Nigel, Gardner, Malcolm, Goble, Arlette, Griffiths-Jones, Sam, Harris, David E., Katzer, Frank, Larke, Natasha, Lord, Angela, Maser, Pascal, McKellar, Sue, Mooney, Paul, Morton, Fraser, Nene, Vishvanath, O'Neil, Susan, Price, Claire, Quail, Michael A., Rabbinowitsch, Ester, Rawlings, Neil D., Rutter, Simon, Saunders, David, Seeger, Kathy, Shah, Trushar, Squares, Robert, Squares, Steven, Tivey, Adrian, Walker, Alan R., Woodward, John, Langsley, Gordon, Rajandream, Marie-Adele, McKeever, Declan, Shiels, Brian, Tait, Andrew, Barrell, Bart, and Hall, Neil

Published
2005

40. The industrial melanism mutation in British peppered moths is a transposable element

Author

Hof, Arjen E. vant, Campagne, Pascal, Rigden, Daniel J., Yung, Carl J., Lingley, Jessica, Quail, Michael A., Hall, Neil, Darby, Alistair C., and Saccheri, Ilik J.

Subjects
Mutation -- Research, Moths -- Genetic aspects -- Environmental aspects, Biological research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Arjen E. vant Hof [1]; Pascal Campagne [1]; Daniel J. Rigden [1]; Carl J. Yung [1]; Jessica Lingley [1]; Michael A. Quail [2]; Neil Hall [1]; Alistair C. Darby [...]

Published
2016
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41. The Earth BioGenome Project 2020: Starting the clock

Author

Lewin, Harris A., Richards, Stephen, Aiden, Erez, Allende, Miguel L., Archibald, John M., Bálint, Miklós M., Barker, Katharine M., Baumgartnerk, Bridget, Belov, Katherine, Bertorelle, Giorgio, Blaxter, Mark, Cai, Jing, Caperello, Nicolette, Carlson, Keith, Castilla-Rubio, Juan Carlos, Chaw, Shu-Miaw, Chen, Lei, Childers, Anna K., Coddington, Jonathan A., Conde, Dalia A., Corominas, Montserrat, Crandall, Keith A., Crawford, Andrew J., Di Palma, Federica, Durbin, Richard, Ebenezer, ThankGod E., Edwards, Scott, Fedrigo, Olivier, Flicek, Paul, Formenti, Giulio, Gibbs, Richard A., Gilbert, M. Thomas P., Goldstein, Melissa M., Marshall Graves, Jennifer A., Greely, Henry, Grigoriev, Igor, Hackett, Kevin J., Hall, Neil, Haussler, David, Helgen, Kristofer M., Hogg, Carolyn J., Isobe, Sachiko, Jakobsen, Kjetill Sigurd, Janke, Axel, Jarvis, Erich D., Johnson, Warren E., Jones, Steven J.M., Karlsson, Elinor K., Kersey, Paul J., Kim, Jin-Hyoung, Kress, W. John, Kuraku, Shigehiro, Lawniczak, Mara K.N., Leebens-Mack, James H., Li, Xueyan, Lindblad-Toh, Kerstin, Liu, Xin, Lopez, Jose V., Marques-Bonet, Tomas, Mazard, Sofhie, Mazet, Jonna, Mazzoni, Camila J., Myers, Eugene W., O'Neill, Rachel J., Paez, Sadye, Park, Hyun, Robinson, Gene, Roquet, Cristina, Ryder, Oliver, Sabir, Jamal S.M., Shaffer, Howard Bradley, Shank, Timothy M., Sherkow, Jacob S., Soltis, Pamela, Tang, Boping, Tedersoo, Leho, Uliano-Silva, Marcela, Wang, Kun, Wei, Xiaofeng, Wetzer, Regina, Wilson, Julia L., Xu, Xun, Yang, Huanming, Yoder, Anne, Zhang, Guojie, Lewin, Harris A., Richards, Stephen, Aiden, Erez, Allende, Miguel L., Archibald, John M., Bálint, Miklós M., Barker, Katharine M., Baumgartnerk, Bridget, Belov, Katherine, Bertorelle, Giorgio, Blaxter, Mark, Cai, Jing, Caperello, Nicolette, Carlson, Keith, Castilla-Rubio, Juan Carlos, Chaw, Shu-Miaw, Chen, Lei, Childers, Anna K., Coddington, Jonathan A., Conde, Dalia A., Corominas, Montserrat, Crandall, Keith A., Crawford, Andrew J., Di Palma, Federica, Durbin, Richard, Ebenezer, ThankGod E., Edwards, Scott, Fedrigo, Olivier, Flicek, Paul, Formenti, Giulio, Gibbs, Richard A., Gilbert, M. Thomas P., Goldstein, Melissa M., Marshall Graves, Jennifer A., Greely, Henry, Grigoriev, Igor, Hackett, Kevin J., Hall, Neil, Haussler, David, Helgen, Kristofer M., Hogg, Carolyn J., Isobe, Sachiko, Jakobsen, Kjetill Sigurd, Janke, Axel, Jarvis, Erich D., Johnson, Warren E., Jones, Steven J.M., Karlsson, Elinor K., Kersey, Paul J., Kim, Jin-Hyoung, Kress, W. John, Kuraku, Shigehiro, Lawniczak, Mara K.N., Leebens-Mack, James H., Li, Xueyan, Lindblad-Toh, Kerstin, Liu, Xin, Lopez, Jose V., Marques-Bonet, Tomas, Mazard, Sofhie, Mazet, Jonna, Mazzoni, Camila J., Myers, Eugene W., O'Neill, Rachel J., Paez, Sadye, Park, Hyun, Robinson, Gene, Roquet, Cristina, Ryder, Oliver, Sabir, Jamal S.M., Shaffer, Howard Bradley, Shank, Timothy M., Sherkow, Jacob S., Soltis, Pamela, Tang, Boping, Tedersoo, Leho, Uliano-Silva, Marcela, Wang, Kun, Wei, Xiaofeng, Wetzer, Regina, Wilson, Julia L., Xu, Xun, Yang, Huanming, Yoder, Anne, and Zhang, Guojie

Published
2022

42. Standards recommendations for the Earth BioGenome Project

Author

Lawniczak, Mara K.N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J, Belov, Katherine, Blaxter, Mark, Marques-Bonet, Tomas, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina, Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca, Kersey, Paul J., Liu, Xin, Lopez, Jose V., Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica, Pruitt, Kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Sahu, Sunil Kumar, Salmon, Nicholas A., Soltis, Pamela, Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill, Zhang, Guojie, Zhang, He, Lewin, Harris A., Richards, Stephen, Lawniczak, Mara K.N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J, Belov, Katherine, Blaxter, Mark, Marques-Bonet, Tomas, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina, Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca, Kersey, Paul J., Liu, Xin, Lopez, Jose V., Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica, Pruitt, Kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Sahu, Sunil Kumar, Salmon, Nicholas A., Soltis, Pamela, Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill, Zhang, Guojie, Zhang, He, Lewin, Harris A., and Richards, Stephen

Abstract

A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.

Published
2022

43. Standards recommendations for the Earth BioGenome Project

Author

Lawniczak, Mara K. N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J., Belov, Katherine, Blaxter, Mark L., Bonet, Tomas Marques, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina J., Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca N., Kersey, Paul J., Liu, Xin, Lopez, Jose Victor, Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica F., Pruitt, Kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Sahu, Sunil Kumar, Salmon, Nicholas A., Soltis, Pamela S., Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill L., Zhang, Guojie, Zhang, He, Lewin, Harris A., Richards, Stephen, Lawniczak, Mara K. N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J., Belov, Katherine, Blaxter, Mark L., Bonet, Tomas Marques, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina J., Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca N., Kersey, Paul J., Liu, Xin, Lopez, Jose Victor, Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica F., Pruitt, Kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Sahu, Sunil Kumar, Salmon, Nicholas A., Soltis, Pamela S., Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill L., Zhang, Guojie, Zhang, He, Lewin, Harris A., and Richards, Stephen

Abstract

A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.

Published
2022
Full Text
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44. Standards recommendations for the Earth BioGenome Project

Author

National Library of Medicine (US), National Institutes of Health (US), Swedish Research Council, National Museum of Natural History Smithsonian Institution, Howard Hughes Medical Institute, Wellcome, European Molecular Biology Laboratory, National Science Foundation (US), Department of Agriculture (US), Agricultural Research Service (US), Lawniczak, Mara K. N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J., Belov, Katherine, Blaxter, Mark, Marqués-Bonet, Tomàs, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina J., Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca N., Kersey, Paul J., Liu, Xin, López, José Víctor, Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica F., Pruitt, kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Kumar Sahu, Sunil, Salmon, Nicholas A., Soltis, Pamela S., Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill L., Zhang, Guojie, Zhang, He, Lewin, Harris A., Richards, Stephen, National Library of Medicine (US), National Institutes of Health (US), Swedish Research Council, National Museum of Natural History Smithsonian Institution, Howard Hughes Medical Institute, Wellcome, European Molecular Biology Laboratory, National Science Foundation (US), Department of Agriculture (US), Agricultural Research Service (US), Lawniczak, Mara K. N., Durbin, Richard, Flicek, Paul, Lindblad-Toh, Kerstin, Wei, Xiaofeng, Archibald, John M., Baker, William J., Belov, Katherine, Blaxter, Mark, Marqués-Bonet, Tomàs, Childers, Anna K., Coddington, Jonathan A., Crandall, Keith A., Crawford, Andrew J., Davey, Robert P., Di Palma, Federica, Fang, Qi, Haerty, Wilfried, Hall, Neil, Hoff, Katharina J., Howe, Kerstin, Jarvis, Erich D., Johnson, Warren E., Johnson, Rebecca N., Kersey, Paul J., Liu, Xin, López, José Víctor, Myers, Eugene W., Vinnere Pettersson, Olga, Phillippy, Adam M., Poelchau, Monica F., Pruitt, kim D., Rhie, Arang, Castilla-Rubio, Juan Carlos, Kumar Sahu, Sunil, Salmon, Nicholas A., Soltis, Pamela S., Swarbreck, David, Thibaud-Nissen, Francoise, Wang, Sibo, Wegrzyn, Jill L., Zhang, Guojie, Zhang, He, Lewin, Harris A., and Richards, Stephen

Abstract

A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.

Published
2022

45. The Earth BioGenome Project 2020:Starting the clock

Author

Lewin, Harris A., Richards, Stephen, Aiden, Erez Lieberman, Allende, Miguel L., Archibald, John M., Bálint, Miklós, Barker, Katharine B., Baumgartner, Bridget, Belov, Katherine, Bertorelle, Giorgio, Blaxter, Mark L., Cai, Jing, Caperello, Nicolette D., Carlson, Keith, Castilla-Rubio, Juan Carlos, Chaw, Shu Miaw, Chen, Lei, Childers, Anna K., Coddington, Jonathan A., Conde, Dalia A., Corominas, Montserrat, Crandall, Keith A., Crawford, Andrew J., DiPalma, Federica, Durbin, Richard, Ebenezer, ThankGod E., Edwards, Scott V., Fedrigo, Olivier, Flicek, Paul, Formenti, Giulio, Gibbs, Richard A., Gilbert, M. Thomas P., Goldstein, Melissa M., Graves, Jennifer Marshall, Greely, Henry T., Grigoriev, Igor V., Hackett, Kevin J., Hall, Neil, Haussler, David, Helgen, Kristofer M., Hogg, Carolyn J., Isobe, Sachiko, Jakobsen, Kjetill Sigurd, Janke, Axel, Jarvis, Erich D., Johnson, Warren E., Jones, Steven J. M., Karlsson, Elinor K., Kersey, Paul J., Kim, Jin Hyoung, Kress, W. John, Kuraku, Shigehiro, Lawniczak, Mara K. N., Leebens-Mack, James H., Li, Xueyan, Lindblad-Toh, Kerstin, Liu, Xin, Lopez, Jose V., Marques-Bonet, Tomas, Mazard, Sophie, Mazet, Jonna A. K., Mazzoni, Camila J., Myers, Eugene W., O’Neill, Rachel J., Paez, Sadye, Park, Hyun, Robinson, Gene E., Roquet, Cristina, Ryder, Oliver A., Sabir, Jamal S. M., Shaffer, H. Bradley, Shank, Timothy M., Sherkow, Jacob S., Soltis, Pamela S., Tang, Boping, Tedersoo, Leho, Uliano-Silva, Marcela, Wang, Kun, Wei, Xiaofeng, Wetzer, Regina, Wilson, Julia L., Xu, Xun, Yang, Huanming, Yoder, Anne D., Zhang, Guojie, Lewin, Harris A., Richards, Stephen, Aiden, Erez Lieberman, Allende, Miguel L., Archibald, John M., Bálint, Miklós, Barker, Katharine B., Baumgartner, Bridget, Belov, Katherine, Bertorelle, Giorgio, Blaxter, Mark L., Cai, Jing, Caperello, Nicolette D., Carlson, Keith, Castilla-Rubio, Juan Carlos, Chaw, Shu Miaw, Chen, Lei, Childers, Anna K., Coddington, Jonathan A., Conde, Dalia A., Corominas, Montserrat, Crandall, Keith A., Crawford, Andrew J., DiPalma, Federica, Durbin, Richard, Ebenezer, ThankGod E., Edwards, Scott V., Fedrigo, Olivier, Flicek, Paul, Formenti, Giulio, Gibbs, Richard A., Gilbert, M. Thomas P., Goldstein, Melissa M., Graves, Jennifer Marshall, Greely, Henry T., Grigoriev, Igor V., Hackett, Kevin J., Hall, Neil, Haussler, David, Helgen, Kristofer M., Hogg, Carolyn J., Isobe, Sachiko, Jakobsen, Kjetill Sigurd, Janke, Axel, Jarvis, Erich D., Johnson, Warren E., Jones, Steven J. M., Karlsson, Elinor K., Kersey, Paul J., Kim, Jin Hyoung, Kress, W. John, Kuraku, Shigehiro, Lawniczak, Mara K. N., Leebens-Mack, James H., Li, Xueyan, Lindblad-Toh, Kerstin, Liu, Xin, Lopez, Jose V., Marques-Bonet, Tomas, Mazard, Sophie, Mazet, Jonna A. K., Mazzoni, Camila J., Myers, Eugene W., O’Neill, Rachel J., Paez, Sadye, Park, Hyun, Robinson, Gene E., Roquet, Cristina, Ryder, Oliver A., Sabir, Jamal S. M., Shaffer, H. Bradley, Shank, Timothy M., Sherkow, Jacob S., Soltis, Pamela S., Tang, Boping, Tedersoo, Leho, Uliano-Silva, Marcela, Wang, Kun, Wei, Xiaofeng, Wetzer, Regina, Wilson, Julia L., Xu, Xun, Yang, Huanming, Yoder, Anne D., and Zhang, Guojie

Published
2022

46. Sequence locally, think globally:The Darwin tree of life project

Author

Barnes, Ian, Berriman, Matthew, Broad, Gavin, Durbin, Richard, Flicek, Paul, Gaya, Ester, Hall, Neil, Hart, Michelle, Holland, Peter, Hollingsworth, Pete, Howe, Kevin, Kersey, Paul, Lawniczak, Mara K N, Lewis, Owen, Mieszkowska, Nova, Richards, Thomas, Twyford, Alexander D, and Wilson, Willie

Abstract

The goals of the Earth Biogenome Project-to sequence the genomes of all eukaryotic life on earth-are as daunting as they are ambitious. The Darwin Tree of Life Project was founded to demonstrate the credibility of these goals and to deliver at-scale genome sequences of unprecedented quality for a biogeographic region: the archipelago of islands that constitute Britain and Ireland. The Darwin Tree of Life Project is a collaboration between biodiversity organizations (museums, botanical gardens, and biodiversity institutes) and genomics institutes. Together, we have built a workflow that collects specimens from the field, robustly identifies them, performs sequencing, generates high-quality, curated assemblies, and releases these openly for the global community to use to build future science and conservation efforts.

Published
2022

47. The Earth BioGenome Project 2020: Starting the clock

Author

Lewin, Harris A., primary, Richards, Stephen, additional, Lieberman Aiden, Erez, additional, Allende, Miguel L., additional, Archibald, John M., additional, Bálint, Miklós, additional, Barker, Katharine B., additional, Baumgartner, Bridget, additional, Belov, Katherine, additional, Bertorelle, Giorgio, additional, Blaxter, Mark L., additional, Cai, Jing, additional, Caperello, Nicolette D., additional, Carlson, Keith, additional, Castilla-Rubio, Juan Carlos, additional, Chaw, Shu-Miaw, additional, Chen, Lei, additional, Childers, Anna K., additional, Coddington, Jonathan A., additional, Conde, Dalia A., additional, Corominas, Montserrat, additional, Crandall, Keith A., additional, Crawford, Andrew J., additional, DiPalma, Federica, additional, Durbin, Richard, additional, Ebenezer, ThankGod E., additional, Edwards, Scott V., additional, Fedrigo, Olivier, additional, Flicek, Paul, additional, Formenti, Giulio, additional, Gibbs, Richard A., additional, Gilbert, M. Thomas P., additional, Goldstein, Melissa M., additional, Graves, Jennifer Marshall, additional, Greely, Henry T., additional, Grigoriev, Igor V., additional, Hackett, Kevin J., additional, Hall, Neil, additional, Haussler, David, additional, Helgen, Kristofer M., additional, Hogg, Carolyn J., additional, Isobe, Sachiko, additional, Jakobsen, Kjetill Sigurd, additional, Janke, Axel, additional, Jarvis, Erich D., additional, Johnson, Warren E., additional, Jones, Steven J. M., additional, Karlsson, Elinor K., additional, Kersey, Paul J., additional, Kim, Jin-Hyoung, additional, Kress, W. John, additional, Kuraku, Shigehiro, additional, Lawniczak, Mara K. N., additional, Leebens-Mack, James H., additional, Li, Xueyan, additional, Lindblad-Toh, Kerstin, additional, Liu, Xin, additional, Lopez, Jose V., additional, Marques-Bonet, Tomas, additional, Mazard, Sophie, additional, Mazet, Jonna A. K., additional, Mazzoni, Camila J., additional, Myers, Eugene W., additional, O’Neill, Rachel J., additional, Paez, Sadye, additional, Park, Hyun, additional, Robinson, Gene E., additional, Roquet, Cristina, additional, Ryder, Oliver A., additional, Sabir, Jamal S. M., additional, Shaffer, H. Bradley, additional, Shank, Timothy M., additional, Sherkow, Jacob S., additional, Soltis, Pamela S., additional, Tang, Boping, additional, Tedersoo, Leho, additional, Uliano-Silva, Marcela, additional, Wang, Kun, additional, Wei, Xiaofeng, additional, Wetzer, Regina, additional, Wilson, Julia L., additional, Xu, Xun, additional, Yang, Huanming, additional, Yoder, Anne D., additional, and Zhang, Guojie, additional

Published
2022
Full Text
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