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2. Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

Author

Chandrasekharappa, Settara C., Guru, Siradanahalli C., Manickam, Pachiappan, Olufemi, Shodimu-Emmanuel, Collins, Francis S., Emmert-Buck, Michael R., Debelenko, Larisa V., Zhuang, Zhengping, Lubensky, Irina A., Liotta, Lance A., Crabtree, Judy S., Wang, Yingping, Roe, Bruce A., Weisemann, Jane, Boguski, Mark S., Agarwal, Sunita K., Kester, Mary Beth, Kim, Young S., Heppner, Christina, Dong, Qihan, Spiegel, Allen M., Burns, A. Lee, and Marx, Stephen J.

Published
1997

3. Genetic interactions between Drosophila melanogaster menin and Jun/Fos

Author

Cerrato, Aniello, Parisi, Michael, Anna, Sonia Santa, Missirlis, Fanis, Guru, Siradanahalli, Agarwal, Sunita, Sturgill, David, Talbot, Thomas, Spiegel, Allen, and Collins, Francis

Subjects
Drosophila -- Genetic aspects, Tumor suppressor genes -- Research, DNA binding proteins -- Research, Biological sciences
Abstract

The genetic interaction between menin, a tumor suppressor and Jun/Fos, a transcription factor in Drosophila melanogaster embryo is discussed.

Published
2006

5. Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

Author

Manickam, Pachiappan, Guru, Siradanahalli C., Debelenko, Larisa V., Agarwal, Sunita K., Olufemi, Shodimu-Emmanuel, Weisemann, Jane M., Boguski, Mark S., Crabtree, Judy S., Wang, Yingping, Roe, Bruce A., Lubensky, Irina A., Zhuang, Zhengping, Kester, Mary Beth, Burns, A. Lee, Spiegel, Allen M., Marx, Stephen J., Liotta, Lance A., Emmert-Buck, Michael R., Collins, Francis S., and Chandrasekharappa, S. C.

Published
1997
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6. Characterization of a MEN1 ortholog from Drosophila melanogaster

Author

Guru, Siradanahalli C., primary, Prasad, Nijaguna B., additional, Shin, Eun J., additional, Hemavathy, Kirugaval, additional, Lu, Jining, additional, Ip, Y.Tony, additional, Agarwal, Sunita K., additional, Marx, Stephen J., additional, Spiegel, Allen M., additional, Collins, Francis S., additional, Oliver, Brian, additional, and Chandrasekharappa, Settara C., additional

Published
2001
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8. Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

Author

Agarwal, Sunita K., primary, Guru, Siradanahalli C., additional, Heppner, Christina, additional, Erdos, Michael R., additional, Collins, Regina M., additional, Park, Sylvia Y., additional, Saggar, Suraj, additional, Chandrasekharappa, Settara C., additional, Collins, Francis S., additional, Spiegel, Allen M., additional, Marx, Stephen J., additional, and Burns, A.Lee, additional

Published
1999
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9. A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus

Author

Guru, Siradanahalli C., primary, Agarwal, Sunita K., additional, Manickam, Pachiappan, additional, Olufemi, Shodimu-Emmanuel, additional, Crabtree, Judy S., additional, Weisemann, Jane M., additional, Kester, Mary Beth, additional, Kim, Young S., additional, Wang, Yingping, additional, Emmert-Buck, Michael R., additional, Liotta, Lance A., additional, Spiegel, Allen M., additional, Boguski, Mark S., additional, Roe, Bruce A., additional, Collins, Francis S., additional, Marx, Stephen J., additional, Burns, Lee, additional, and Chandrasekharappa, Settara C., additional

Published
1997
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10. A 2.8-Mb Clone Contig of the Multiple Endocrine Neoplasia Type 1 (MEN1) Region at 11q13

Author

Guru, Siradanahalli C., primary, Olufemi, Shodimu-Emmanuel, additional, Manickam, Pachiappan, additional, Cummings, Christiano, additional, Gieser, Linn M., additional, Pike, Brian L., additional, Bittner, Michael L., additional, Jiang, Yuan, additional, Chinault, A.Craig, additional, Nowak, Norma J., additional, Brzozowska, Anna, additional, Crabtree, Judy S., additional, Wang, Yingping, additional, Roe, Bruce A., additional, Weisemann, Jane M., additional, Boguski, Mark S., additional, Agarwal, Sunita K., additional, Burns, A.Lee, additional, Spiegel, Allen M., additional, Marx, Stephen J., additional, Flejter, Wendy L., additional, de Jong, Pieter J., additional, Collins, Francis S., additional, and Chandrasekharappa, Settara C., additional

Published
1997
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11. Loss of Heterozygosity at 11q13: Analysis of Pituitary Tumors, Lung Carcinoids, Lipomas, and Other Uncommon Tumors in Subjects with Familial Multiple Endocrine Neoplasia Type 1

Author

Dong, Qihan, primary, Debelenko, Larisa V., additional, Chandrasekharappa, Settara C., additional, Emmert-Buck, Michael R., additional, Zhuang, Zhengping, additional, Guru, Siradanahalli C., additional, Manickam, Pachiappan, additional, Skarulis, Monica, additional, Lubensky, Irina A., additional, Liotta, Lance A., additional, Collins, Francis S., additional, Marx, Stephen J., additional, and Spiegel, Allen M., additional

Published
1997
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12. Characterization of a MEN1ortholog from Drosophilamelanogaster

Author

Guru, Siradanahalli C., Prasad, Nijaguna B., Shin, Eun J., Hemavathy, Kirugaval, Lu, Jining, Ip, Y.Tony, Agarwal, Sunita K., Marx, Stephen J., Spiegel, Allen M., Collins, Francis S., Oliver, Brian, and Chandrasekharappa, Settara C.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome characterized by tumors of the parathyroid, entero-pancreatic neuroendocrine and pituitary tissues and caused by inactivating mutations in the MEN1gene. Menin, the 610-amino acid nuclear protein encoded by MEN1, binds to the transcription factor JunD and can repress JunD-induced transcription. We report here the identification of a MEN1ortholog in Drosophilamelanogaster, Menin1, that encodes a 763 amino acid protein sharing 46% identity with human menin. Additionally, 69% of the missense mutations and in-frame deletions reported in MEN1 patients appear in amino acid residues that are identical in the Drosophila and human protein, suggesting the importance of the conserved regions. Drosophila Menin1gene transcripts use alternative polyadenylation sites resulting in 4.3 and 5-kb messages. The 4.3-kb transcript appears to be largely maternal, while the 5-kb transcript appears mainly zygotic. The binding of Drosophila menin to human JunD or Drosophila Jun could not be demonstrated by the yeast two-hybrid analysis. The identification of the MEN1ortholog from Drosophilamelanogasterwill provide an opportunity to utilize Drosophila genetics to enhance our understanding of the function of human menin.

Published
2001
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