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Hierarchical multi-label text classification (HMTC) is a highly relevant and widely discussed topic in the era of big data, particularly for efficiently classifying extensive amounts of text data. This study proposes the HTMC-PGT framework for poverty governance’s single-path hierarchical multi-label classification problem. The framework simplifies the HMTC problem into training and combination problems of multi-class classifiers in the classifier tree. Each independent classifier in this framework uses an XLNet pretrained model to extract char-level semantic embeddings of text and employs a hierarchical attention mechanism integrated with Bi-LSTM (BiLSTM + HA) to extract semantic embeddings at the document level for classification purposes. Simultaneously, this study proposes that the structure uses transfer learning (TL) between classifiers in the classifier tree. The experimental results show that the proposed XLNet + BiLSTM + HA + FC + TL model achieves micro-P, micro-R, and micro-F1 values of 96.1%, which is 7.5~38.1% higher than those of other baseline models. The HTMC-PGT framework based on XLNet, BiLSTM + HA, and transfer learning (TL) between classifier tree nodes proposed in this study solves the hierarchical multi-label classification problem of poverty governance text (PGT). It provides a new idea for solving the traditional HMTC problem.

Gastrointestinal (GI) tumors, including liver, pancreatic, gastric, and colorectal cancers, have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent relapses. Surgery and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors, but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug resistance. Recent studies have shown that ferroptosis plays an important role in the onset and progression of GI tumors. Ferroptosis is a new non-apoptotic form of cell death, which is iron-dependent, non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS). The activation of ferroptosis can lead to tumor cell death. Thus, regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors, making it become a research hotspot. Current studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ROS. Furthermore, several studies have indicated that ferroptosis may be a new approach for the treatment of GI tumors. Here, we review current research progress on the mechanism of ferroptosis, current inducers and inhibitors of ferroptosis, and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors.

The harmonic reducer of the space drive mechanism is one of the critical components of the satellite remote sensing system and its reliability is always required strictly in practice. During the manufacturing and usage processes of the harmonic reducer, uncertainties are ubiquitous and performance degradation is inevitable, which is mainly caused by the wear between the meshed tooth surfaces. They influence the reliability of harmonic reducer. In this paper, a performance margin modeling and reliability analysis for harmonic reducer considering multi-source uncertainties and wear is proposed. Firstly, based on the functional principle and the influence of wear, the performance margin model is established using hysteresis and transmission errors as key performance parameters. Then multi-source uncertainties are analyzed and quantified, including manufacturing errors, uncertainties in operational and environmental conditions, and uncertainties in performance thresholds. Finally, the reliability model is constructed based on the performance margin. A case study of a harmonic reducer is applied and the reliability sensitivity analysis is implemented to show the practicability of the proposed method. The results show that the proposed method can provide some suggestions to the design and manufacturing phases of the harmonic reducer.

Background: Aromatase inhibitor-induced arthralgia (AIA) is the most common side effect of aromatase inhibitors (AIs) used in breast cancer patients and is related to the rate of adherence to AIs. The clinical effects of acupuncture on AIA have been assessed by some randomized controlled trials (RCTs). However, some studies reported that acupuncture was effective, while others claimed that it was ineffective. To clarify the clinical and placebo effects of acupuncture in treating AIA, we conducted this meta-analysis. Methods: Two reviewers (XL and GW) independently searched for RCTs in 5 English databases (PubMed, Web of Science, Embase, Springer, Cochrane Library) and 4 Chinese databases (China National Knowledge Infrastructure Database (CNKI), SinoMed, VIP and Wanfang Database) from their inception to 30 November 2019. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this meta-analysis was performed by fixed or random-effects models, and data were pooled with mean differences (MDs). Results: Seven trials involving 603 patients were reviewed. The primary outcome, the Brief Pain Inventory (BPI) score, significantly differed between the acupuncture and control groups [pain-related interference: MD = −1.89, 95% confidence interval (CI) [−2.99, −0.79], Z = 3.36 ( P = .008 Conclusion: This meta-analysis showed that acupuncture is a safe and effective treatment for breast cancer patients with AIA. Additional research with improved blinding methods is warranted to further explore the nature of non-specific and placebo effects in true and sham acupuncture.

Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The influenza polymerase with three proteins, PA, PB1 and PB2, is a crucial component of the viral ribonucleoprotein (RNP) complex. Here, we report the identification of a hit compound 221 by surface plasmon resonance (SPR) direct binding screening on the C-terminal of PA (PAC). Compound 221 can subdue influenza RNP activities and attenuate influenza virus replication. Its analogs were subsequently investigated and twelve of them could attenuate RNP activities. One of the analogs, compound 312, impeded influenza A virus replication in Madin-Darby canine kidney cells with IC50 of 27.0 ± 16.8 μM. In vitro interaction assays showed that compound 312 bound directly to PAC with Kd of about 40 μM. Overall, the identification of novel PAC-targeting compounds provides new ground for drug design against influenza virus in the future.

Objective: To study the effect of mid-frequency pulse therapy combined with external fixation on bone metabolism, inflammatory response and oxidative stress in patients with osteoporotic distal radial fractures. Methods: A total of 72 patients with osteoporotic distal radial fractures who were treated in the hospital between September 2015 and January 2017 were collected and divided into control group (n=36) and observation group (n=36) according to the random number table method. Control group received routine external fixation, and observation group received mid-frequency pulse therapy combined with external fixation. The differences in serum levels of bone metabolism indexes, inflammatory factors and oxidative stress indexes were compared between two groups of patients before and after treatment. Results: Before treatment, differences in serum levels of bone metabolism indexes, inflammatory factors and oxidative stress indexes were not statistically significant between the two groups. After 1 month of treatment, serum BGP, TAC and SOD levels of both groups of patients were higher than those before treatment while β-CTX, AKP, TRAP, CRP, IL-1β, IL-6 and MDA levels were lower than those before treatment, and serum BGP, TAC and SOD levels of observation group were higher than those of control group while β-CTX, AKP, TRAP, CRP, IL-1β, IL-6 and MDA levels were lower than those of control group. Conclusion: Mid-frequency pulse therapy combined with external fixation can promote fracture healing and reduce postoperative inflammatory response and oxidative stress response in patients with osteoporotic distal radial fracture.

For the characteristics of the continuous stirred-tank reactor (CSTR) with coil and jacket cooling system, a CSTR temperature dual control solution based on the analysis of the CSTR exothermic reaction control characteristic was proposed for an organic material polymerization production. The control solution has passive fault-tolerant ability for the jacket cooling water cutting off fault and active fault-tolerant potential for the coil cooling water cutting off fault, and it has good control ability, high saving energy and reducing consumption performance. Fault detection and diagnosis and fault-tolerant control strategy are designed for the coil cooling fault to achieve the active fault-tolerant control function. The CSTR temperature dual control, process fault detection and diagnosis and active fault-tolerant control were full integrated into the CSTR temperature fault-tolerant control system, which achieve fault tolerance control of CSTR temperature for any severe malfunction of jacket cooling or coil cooling cutting off, and the security for CSTR exothermic reaction is improved. Finally, the effectiveness of this system was validated by semi-physical simulation experiment.

This paper proposes a modified strain wedge model for the nonlinear analysis of laterally loaded single piles in sandy soils by using the Duncan–Chang model as well as the Mohr–Coulomb model to describe the stress–strain behavior of soils in the strain wedge. The input soil property for sandy soils only needs a relative density which can be easily estimated from in situ tests. The strain wedge depth is calculated by an iterative process and the subgrade reaction modulus below the strain wedge is assumed to increase linearly with depth, though it does not change with the lateral load applied to the pile. Seven case histories are used to verify the applicability of the proposed method. The results show the following: (1) good agreements are found between the predicted and the measured results of full scale tested piles; (2) the predicted deflections and moments using the Duncan–Chang model are almost the same as those using the Mohr–Coulomb model; and (3) the size effect of the pile diameter or width on the subgrade reaction modulus should be considered.

// Da-Jian Zhu 1, 2, * , Yan-Feng Huang 3, * , Xiao-Wu Chen 1 , Zhen-Tao Luo 1 , Guo-Xin Wang 1 , Chang-Chun Liu 1 , Wei-Jie Zhang 1 , Man-Zhao Ouyang 1 1 Department of Gastrointestinal Surgery, Shunde First People’s Hospital Affiliated to Southern Medical University, Guangdong 528300, China 2 Department of Gastrointestinal Surgery, Shunde Women and Children’s Hospital Affiliated to Jinan University, Guangdong 528300, China 3 Department of Traditional Chinese Medicine, Shunde First People’s Hospital Affiliated to Southern Medical University, Guangdong 528300, China * These authors have contributed equally to this work Correspondence to: Xiao-Wu Chen, email: drchenxiaowu@163.com Keywords: curcumin, colorectal cancer, irinotecan, diarrhea, oxidative stress Received: December 07, 2015 Accepted: May 12, 2016 Published: July 14, 2016 ABSTRACT OBJECTIVE: Development of treatment resistance and adverse toxicity limits the gains made by irinotecan in patients with colorectal cancer. According to our previous studies, we found that curcumin could enhance the efficacy of irinotecan-induced apoptosis of colorectal tumor cells in vitro. This study aims to examine the effectiveness of a combination treatment regimen of irinotecan and curcumin in the colorectal cancer xenograft model. RESULTS: Curcumin or irinotecan alone reduced the tumor volume, and the combination had the strongest anticancer effects. Oxidative stress was induced in tumor (MDA: P < 0.01, GPx: P < 0.05, PRDX4: P < 0.01), while was reduced in intestinal tissue (MDA: P < 0.01, SOD: P < 0.05, GPx: P < 0.01). The apoptosis in tumor was accompanied by up-regulation of apoptotic proteins (caspase-3: P < 0.01, Bax: P < 0.01), but down-regulation of anti-apoptotic proteins (pro-caspase-3: P < 0.01, Bcl-2: P < 0.01). Besides, the combination treatment alleviated diarrhea and intestine injury, and also restored the autophagy (PGC-1α: P < 0.05, Atg-7: P < 0.05, and LC3B: P < 0.05) and mitochondrial dynamics (Mfn-1: P < 0.01, Mfn-2: P < 0.01, Drp-1: P < 0.01, Fis-1: P < 0.05) in intestinal tissue. MATERIALS AND METHODS: Nude mice were implanted with LoVo colorectal cancer cells before randomization into the following treatment groups: control; curcumin only; irinotecan only; curcumin + irinotecan. After a 9-day treatment, we compared the tumor weight, tumor volume, morphological change of intestine, and oxidative stress factors (LDH, MDA, SOD, GPx). In addition, we detected the oxidative stress (PRDX4, MnSOD, and p53), apoptosis (Bax, Bcl-2, pro-caspase-3, cleaved-caspase-3) and autophagy (PGC-1α, Atg-7, and LC3B) signaling. CONCLUSIONS: Curcumin could enhance the efficacy of irinotecan-induced apoptosis of colorectal cancer in vivo, while restore the irinotecan-induced autophagy of small intestinal epithelium.

This paper focuses on the wind-induced vibration control of the Dalian international trade mansion (DITM) by using the tuned liquid dampers (TLDs). To avoid the intensive computationally demanding problem caused by tens of thousand of degrees of freedom (DOF) of the structure in the numerical analysis, the three-dimension finite element model of the DITM is first simplified to the equivalent series multi-DOF system. The wind loading is subsequently simulated by the Davenport model according to the structural environmental condition where the actual samples of wind speed are measured. Following that, the shallow- and deep-water wave theories are applied to model the liquid sloshing inside TLDs, the tank sizing, and required water depth, and numbers of TLDs are given according to the numerical results of different cases. Comparisons between uncontrolled and controlled displacement and acceleration responses of the DITM under wind forces show that the designed shallow tank has higher efficiency than the deep one, which can effectively reduce the structural response amplitudes and enhance the comfortableness of the mansion. The preliminary TLD design procedure presented in this paper could be applied as a reference to the analysis and design of the wind-induced vibration for high-rise buildings using the TLD.

A random synthesis procedure based on finite fault model is adopted for near field strong ground motion simulation in this paper. The fault plane of the source is divided into a number of sub-sources, the whole moment magnitude is also divided into more sub-events. The Fourier spectrum of ground motion caused by a sub-event in given sub-source, then can be derived by means of taking the point source spectrum, attenuation with distance, energy dissipation, and near surface effect, into account. A time history is synthesized from this amplitude spectrum and a random phase spectrum, and being combined with an envelope function. The ground motion is worked out by superposition of all time histories from each sub-event in each sub-source, with time lags determining by the differences between the triggering times of sub-events and distances of the sub-sources. From the example of simulations at 21 near field points in a scenario earthquake with 4 dip angles of the fault plane, it is illustrated that the procedure can describe the rupture directivity and hanging wall effect very well. To validate the procedure, the response spectra and time histories recorded at three near fault stations MCN, LV3 and PCD during the Northridge earthquake in 1994, are compared with the simulated ones.