Search

Your search keyword '"Guo, ShiYu"' showing total 116 results
Start Over Author "Guo, ShiYu" Search Limiters Full Text
116 results on '"Guo, ShiYu"'

1. AUITestAgent: Automatic Requirements Oriented GUI Function Testing

Author

Hu, Yongxiang, Wang, Xuan, Wang, Yingchuan, Zhang, Yu, Guo, Shiyu, Chen, Chaoyi, Wang, Xin, and Zhou, Yangfan

Subjects
Computer Science - Software Engineering
Abstract

The Graphical User Interface (GUI) is how users interact with mobile apps. To ensure it functions properly, testing engineers have to make sure it functions as intended, based on test requirements that are typically written in natural language. While widely adopted manual testing and script-based methods are effective, they demand substantial effort due to the vast number of GUI pages and rapid iterations in modern mobile apps. This paper introduces AUITestAgent, the first automatic, natural language-driven GUI testing tool for mobile apps, capable of fully automating the entire process of GUI interaction and function verification. Since test requirements typically contain interaction commands and verification oracles. AUITestAgent can extract GUI interactions from test requirements via dynamically organized agents. Then, AUITestAgent employs a multi-dimensional data extraction strategy to retrieve data relevant to the test requirements from the interaction trace and perform verification. Experiments on customized benchmarks demonstrate that AUITestAgent outperforms existing tools in the quality of generated GUI interactions and achieved the accuracy of verifications of 94%. Moreover, field deployment in Meituan has shown AUITestAgent's practical usability, with it detecting 4 new functional bugs during 10 regression tests in two months.

Published
2024

2. Research Progress in Ferroptosis during Postmortem Aging of Muscle and Its Relationship with the Quality of Fresh Meat

Author

HAO Danni, TU Xiaohang, GUO Shiyu, ZHU Yongzhi, WANG Daoying, XU Weimin, LI Pengpeng

Subjects
ferroptosis, postmortem aging, quality, iron homeostasis imbalance, redox imbalance, lipoperoxidation, Food processing and manufacture, TP368-456
Abstract

Water-holding capacity, texture and color are important indicators of fresh meat quality. In China, drip loss and textural deterioration of fresh meat are critical problems in the meat industry, causing greater quality loss than that in developed countries. Recently, researchers have identified a series of potential biomarkers for the water-holding capacity and tenderness of meat and have studied the effect of cell apoptosis on meat tenderness. However, the relationship between ferroptosis and fresh meat quality has been researched little. After slaughter, the intramuscular environment alters and ferroptosis occurs, which is characterized by the accumulation of iron, an increase in lipid oxidation and disruption of redox equilibrium. These changes are closely related to meat quality. This paper reviews the characteristics, metabolic pathways and regulatory mechanisms of ferroptosis, and the crosslinks between ferroptosis and other modes of cell death. Moreover, it elaborates on how ferroptosis affects fresh meat quality through iron homeostasis imbalance, redox imbalance and lipoperoxidation. Overall, this review provides deeper insights into the mechanism of meat quality formation during postmortem aging.

Published
2024
Full Text
View/download PDF

9. Flowering time regulator qFT13‐3 involved in soybean adaptation to high latitudes.

Author

Li, Yan‐fei, Zhang, Liya, Wang, Jun, Wang, Xing, Guo, Shiyu, Xu, Ze‐jun, Li, Delin, Liu, Zhangxiong, Li, Ying‐hui, Liu, Bin, and Qiu, Li‐juan

Subjects
FLOWERING time, CIRCADIAN rhythms, NATURAL selection, GENOME-wide association studies, LATITUDE, PRORENIN receptor, CULTIVARS, SOYBEAN
Abstract

Summary: Soybean is a short‐day plant that typically flowers earlier when exposed to short‐day conditions. However, the identification of genes associated with earlier flowering time but without a yield penalty is rare. In this study, we conducted genome‐wide association studies (GWAS) using two re‐sequencing datasets that included 113 wild soybeans (G. soja) and 1192 cultivated soybeans (G. max), respectively, and simultaneously identified a candidate flowering gene, qFT13‐3, which encodes a protein homologous to the pseudo‐response regulator (PRR) transcription factor. We identified four major haplotypes of qFT13‐3 in the natural population, with haplotype H4 (qFT13‐3H4) being lost during domestication, while qFT13‐3H1 underwent natural and artificial selection, increasing in proportion from 4.5% in G. soja to 43.8% in landrace and to 81.9% in improve cultivars. Notably, most cultivars harbouring qFT13‐3H1 were located in high‐latitude regions. Knockout of qFT13‐3 accelerated flowering and maturity time under long‐day conditions, indicating that qFT13‐3 functions as a flowering inhibitor. Our results also showed that qFT13‐3 directly downregulates the expression of GmELF3b‐2 which is a component of the circadian clock evening complex. Field trials revealed that the qft13‐3 mutants shorten the maturity period by 11 days without a concomitant penalty on yield. Collectively, qFT13‐3 can be utilized for the breeding of high‐yield cultivars with a short maturity time suitable for high latitudes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Deep Learning-Based Optimization Framework for Full-Waveform Inversion in Tunnels

Author

Jiang, Peng, Cao, Shuai, Guo, Shiyu, Ren, Yuxiao, and Li, Yong

Abstract

Recently, geophysical exploration methods have been prevalently used in ahead geological prospecting in tunneling. Among all kinds of geophysical exploration methods, the seismic method is more popular because of its interface sensitivity and long detection distance. However, because of the tunnel observation limitation and the detection data lacking, the seismic method represented by the full-waveform inversion (FWI) does not work well with satisfactory precision for tunnel geology detection and cannot meet tunnel construction safety requirements. Therefore, studying the high-precision seismic method suitable for tunnel environments is in great demand. To address these problems, we propose optimizing the full-waveform inversion by deep learning from the inversion interface and velocity value. To optimize the interface, we built a virtual tunnel observation system similar to the observation system on the ground with a large offset distance to obtain accurate interface gradients. Then, we learn the mapping between the actual tunnel gradients and virtual gradients. Finally, the virtual gradients are used to update the velocity model. To optimize the velocity value, we adopt another specific network to help full-wave inversion get out of local minima. Extensive model and field tests, as well as interpretability studies, verify the feasibility and effectiveness of the proposed method.

Published
2024
Full Text
View/download PDF

15. Time series canopy phenotyping enables the identification of genetic variants controlling dynamic phenotypes in soybean

Author

Li, Delin, primary, Bai, Dong, additional, Tian, Yu, additional, Li, Ying‐Hui, additional, Zhao, Chaosen, additional, Wang, Qi, additional, Guo, Shiyu, additional, Gu, Yongzhe, additional, Luan, Xiaoyan, additional, Wang, Ruizhen, additional, Yang, Jinliang, additional, Hawkesford, Malcolm J., additional, Schnable, James C., additional, Jin, Xiuliang, additional, and Qiu, Li‐Juan, additional

Published
2022
Full Text
View/download PDF

16. Estimation of soybean yield parameters under lodging conditions using RGB information from unmanned aerial vehicles

Author

Bai, Dong, primary, Li, Delin, additional, Zhao, Chaosen, additional, Wang, Zixu, additional, Shao, Mingchao, additional, Guo, Bingfu, additional, Liu, Yadong, additional, Wang, Qi, additional, Li, Jindong, additional, Guo, Shiyu, additional, Wang, Ruizhen, additional, Li, Ying-hui, additional, Qiu, Li-juan, additional, and Jin, Xiuliang, additional

Published
2022
Full Text
View/download PDF

20. Time series canopy phenotyping enables the identification of genetic variants controlling dynamic phenotypes in soybean.

Author

Li, Delin, Bai, Dong, Tian, Yu, Li, Ying‐Hui, Zhao, Chaosen, Wang, Qi, Guo, Shiyu, Gu, Yongzhe, Luan, Xiaoyan, Wang, Ruizhen, Yang, Jinliang, Hawkesford, Malcolm J., Schnable, James C., Jin, Xiuliang, and Qiu, Li‐Juan

Subjects
GENETIC variation, TIME series analysis, LOCUS (Genetics), PLANT breeding, PHENOTYPES
Abstract

Advances in plant phenotyping technologies are dramatically reducing the marginal costs of collecting multiple phenotypic measurements across several time points. Yet, most current approaches and best statistical practices implemented to link genetic and phenotypic variation in plants have been developed in an era of single‐time‐point data. Here, we used time‐series phenotypic data collected with an unmanned aircraft system for a large panel of soybean (Glycine max (L.) Merr.) varieties to identify previously uncharacterized loci. Specifically, we focused on the dissection of canopy coverage (CC) variation from this rich data set. We also inferred the speed of canopy closure, an additional dimension of CC, from the time‐series data, as it may represent an important trait for weed control. Genome‐wide association studies (GWASs) identified 35 loci exhibiting dynamic associations with CC across developmental stages. The time‐series data enabled the identification of 10 known flowering time and plant height quantitative trait loci (QTLs) detected in previous studies of adult plants and the identification of novel QTLs influencing CC. These novel QTLs were disproportionately likely to act earlier in development, which may explain why they were missed in previous single‐time‐point studies. Moreover, this time‐series data set contributed to the high accuracy of the GWASs, which we evaluated by permutation tests, as evidenced by the repeated identification of loci across multiple time points. Two novel loci showed evidence of adaptive selection during domestication, with different genotypes/haplotypes favored in different geographic regions. In summary, the time‐series data, with soybean CC as an example, improved the accuracy and statistical power to dissect the genetic basis of traits and offered a promising opportunity for crop breeding with quantitative growth curves. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

22. The prevalence of deleterious mutations during the domestication and improvement of soybean

Author

Sun, Shichao, Wang, Yumin, Wei, He, Hufnagel, David E., Wang, Ya, Guo, Shiyu, Li, Yinghui, Wang, Li, and Qiu, Li-juan

Abstract

Soybean (Glycine maxL.) is a protein and oil crop grown worldwide. Its fitness may be reduced by deleterious mutations, whose identification and purging is desirable for crop breeding. In the published whole-genome re-sequenced data of 2214 soybean accessions, including 221 wild soybean, 1132 landrace cultivars and 861 improved soybean lines, we identified 115,275 deleterious single-nucleotide polymorphisms (SNPs). Numbers of deleterious alleles increased from wild soybeans to landraces and decreased from landraces to modern improved lines. Genes in selective-sweep regions showed fewer deleterious mutations than the remaining genes. Deleterious mutations explained 4.3%–48% more phenotypic variation than randomly selected SNPs for resistance to soybean cyst nematode race 2 (SCN2), soybean cyst nematode race 3 (SCN3) and soybean mosaic virus race 3 (SMV3). These findings illustrate how mutation load has shifted during soybean domestication, expansion and improvement and provide candidate sites for breeding out deleterious mutations in soybean by genome editing and/or conventional breeding focused on the selection of progeny with fewer deleterious alleles.

Published
2023
Full Text
View/download PDF

26. Application Readiness of Fuel Cell City-bus in China

Author

Wu, Xiaoyuan, Guo, Shiyu, Zuo, Zhelun, Wang, Ru, and He, Jianhui

Subjects
Bus, fuel cell electric vehicle (FCEV), Business Model, Public Transport, Market Development
Abstract

In recent years, fuel cell city-buses (FCCBs) application in urban public transport have been rapidly developed in China that over 20 cities have operated more than 1300 FCCBs by 2019. We use the readiness to analyse development of FCCB application in different cities. Factors affecting the readiness are classified by four dimensions, from which a model is constructed by survey, analytic hierarchy process (AHP), and etc. Based on the model, we calculate cities’ readiness and cluster cities into different types. For each type of city, suggestions to increase their readiness or improve preparation for FCCB application are put forward.

Published
2020
Full Text
View/download PDF

29. Fabrication of ionic wood crosslinked by Ca2+with high strength, toughness, and weather resistance

Author

Zhang, Xuefeng, Wang, Huanbo, Chen, Zhijun, Guo, Shiyu, Fu, Yuan, and Liu, Tian

Abstract

Fast-growing natural poplar wood is not meet with in many requirements such as high strength and flame retardant due to its porous structure and loose materials. In this study, we established a simple and feasible method that includes delignification, ionic bond formation via the crosslinking of carboxyl groups in TEMPO-oxidized wood after delignification with calcium ions, and hot-pressing of stacked veneers to improve the quality, density, strength, toughness, and weather resistance of natural wood (NW). This method has the following advantages: The inner cellulose microfiber is highly aligned, thus closely cross-linking and tightly bonding cellulose microfibers and nanofibers between the interfaces and inner layers of the wood boards via hydrogen bonding and ionic bonding. A laminated densified TEMPO-oxidized ionic wood (IW) showed substantially higher specific strength (∼196.9 MPa cm3 g−1), higher tensile strength (∼246 MPa), higher flexural strength (∼257 MPa), higher flexural modulus (∼36 GPa), higher impact toughness (∼42.34 kJ m−2), and superior fire retardancy, UV resistance, water resistance, and also higher density (∼1.25 g cm−3) than NW. Larger-size laminated densified structural materials with satisfactory thermal stability can also be fabricated using the proposed method.

Published
2022
Full Text
View/download PDF

34. Vasculogenic mimicry in hepatocellular carcinoma contributes to portal vein invasion

Author

Guo Shiyu, Wu Zhi-Feng, Gu Hao, Tadashi Hisamitsu, Jin Feng, Liu Yanqing, Ishikawa Shintaro, Zhang Zhisheng, Qian Yayun, Cui Lin, and Chen Jue

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Pathology, Carcinoma, Hepatocellular, medicine.medical_treatment, Tumor resection, Portal vein, Vimentin, Liver transplantation, Gastroenterology, Resection, hepatocellular carcinoma (HCC), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, portal vein invasion (PVI), medicine, Humans, Vasculogenic mimicry, Notch1, Neovascularization, Pathologic, biology, vasculogenic mimicry (VM), Portal Vein, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, biology.protein, Immunohistochemistry, Female, business, Research Paper
Abstract

// Chen Jue 1, 2, 3, * , Wu Zhifeng 4, * , Zhang Zhisheng 2 , Cui Lin 2 , Qian Yayun 1 , Jin Feng 1 , Gu Hao 1 , Ishikawa Shintaro 3 , Tadashi Hisamitsu 3 , Guo Shiyu 3 , Liu Yanqing 1 1 Institution of Integrated Traditional Chinese and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China 2 Department of Oncology, The Second People’s Hospital of Taizhou Affiliated to Yangzhou University, Taizhou, Jiangsu, China 3 Department of Physiology, School of Medicine, Showa University, Tokyo, Japan 4 Department of Oncology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Liu Yanqing, email: liuyanqingyzu@163.com Keywords: hepatocellular carcinoma (HCC), vasculogenic mimicry (VM), portal vein invasion (PVI), Notch1 Received: August 31, 2016 Accepted: October 12, 2016 Published: October 25, 2016 ABSTRACT Portal vein invasion (PVI) is common in hepatocellular carcinoma (HCC) and largely contributes to tumor recurrence after radical tumor resection or liver transplantation. Vasculogenic mimicry (VM) was an independent vascular system lined with tumor cells and associated with poor prognosis of HCC. The present study was conducted to evaluate the relationship between VM and portal vein invasion. A total of 44 HCC cases receiving anatomic liver resection were included in the study and were divided into groups with and without PVI. The prevalence of VM in each group was examined by CD34-PAS dual staining. The regulatory molecules of VM formation such as Notch1, Vimentin and matrix metalloproteinases (MMPs) were investigated by immunohistochemical staining. Analysis was performed to explore the association of PVI, VM and the VM regulatory molecules. PVI was found in 40.91% (18/44) cases and VM was found in 38.64% (17/44) cases in total samples. The incidence of VM was 72.22% (13/18) in PVI group while it was 15.38% (4/26) in non-PVI group (P

Published
2016
Full Text
View/download PDF

35. Notch1 promotes vasculogenic mimicry in hepatocellular carcinoma by inducing EMT signaling

Author

Zhang Zhisheng, Qian Yayun, Shi Youyang, Wang Haibo, Tadashi Hisamitsu, Guo Shiyu, Ishikawa Shintaro, Cui Lin, Liu Yanqing, Chen Jue, Zhao Min, and Jin Feng

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Angiogenesis, Mice, Nude, hepatocellular carcinoma (HCC), Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Animals, Humans, Medicine, Vasculogenic mimicry, Receptor, Notch1, Notch1, Matrigel, Gene knockdown, Neovascularization, Pathologic, vasculogenic mimicry (VM), business.industry, Liver Neoplasms, Hep G2 Cells, Hypervascularity, medicine.disease, digestive system diseases, Up-Regulation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Cell culture, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, embryonic structures, cardiovascular system, Cancer research, sense organs, biological phenomena, cell phenomena, and immunity, business, epithelial-to-mesenchymal transition (EMT), Neoplasm Transplantation, Research Paper
Abstract

// Chen Jue 1, 2, 3, * , Cui Lin 2, * , Zhang Zhisheng 2, * , Qian Yayun 1 , Jin Feng 1 , Zhao Min 1 , Wang Haibo 1 , Shi Youyang 1 , Tadashi Hisamitsu 3 , Ishikawa Shintaro 3 , Guo Shiyu 3 , Liu Yanqing 1 1 Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China 2 Department of Oncology, the Second Peoples Hospital of Taizhou affiliated to Yangzhou University, Taizhou, Jiangsu, China 3 Department of Physiology, School of Medicine, Showa University, Tokyo, Japan * These authors have contributed equally to this work Correspondence to: Liu Yanqing, email: liuyanqingyzu@163.com Keywords: vasculogenic mimicry (VM), hepatocellular carcinoma (HCC), Notch1, epithelial-to-mesenchymal transition (EMT) Received: August 02, 2016 Accepted: September 23, 2016 Published: October 1, 2016 ABSTRACT Hypervascularity is one of the main characteristics of hepatocellular carcinoma (HCC). However, the mechanisms of angiogenesis in HCC remain controversial. In this study, we investigate the role of Notch1 in angiogenesis of HCC. We found that Notch1 expression was correlated with formation of vasculogenic mimicry (VM) and expression of biomarkers of epithelial-to-mesenchymal transition (EMT) in the tumor specimens. Two HCC cell lines, HepG2 and MHCC97-H, with low and high Notch1 expression, respectively, were used to study the mechanism of VM formation both in vitro and in vivo . It was found that MHCC97-H cells, but not HepG2 cells form VM when they grow on matrigel in vitro . HepG2 cells gained the power of forming VM when they were overexpressed with Notch1, while knockdown Notch1 expression in MHCC97-H cells led to the loss of VM forming ability of the cells. Similar results were found in in vivo study. High expression of Notch1 in HepG2 promoted xenograft growth in nude mice, with abundant VM formation in the tumor samples. Moreover, we observed Notch1 was associated with the EMT and malignant behavior of hepatocellular carcinoma by analyzing clinical specimens, models for in vitro and in vivo experiments. HepG2 presented EMT phenomenon when induced by TGF-β1, accompanied by Notch1 activation while MHCC97-H with knockdown of Notch1 lost the responsiveness to TGF-β1 induction. Our results suggest that Notch1 promotes HCC progression through activating EMT pathway and forming VM. Our results will guide targeting Notch1 in new drug development.

Published
2016
Full Text
View/download PDF

38. Celastrus�orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in�vitro via the PI3K/AKT/mTOR signaling pathway

Author

Jin, Feng, primary, Zhu, Guang, additional, Li, Dan, additional, Ni, Tengyang, additional, Dai, Xiaojun, additional, Wang, Haibo, additional, Feng, Jun, additional, Qian, Yayun, additional, Yang, Lin, additional, Guo, Shiyu, additional, Hisamitsu, Tadashi, additional, and Liu, Yanqing, additional

Published
2017
Full Text
View/download PDF

40. GmAP1dregulates flowering time under long-day photoperiods in soybean

Author

Guo, Shiyu, Li, Yanfei, Qiu, Hongmei, Hu, Guoyu, Zhao, Chaosen, Wang, Ruizhen, Zhang, Hao, Tian, Yu, Li, Xiaoyu, Liu, Bin, Li, Ying-hui, and Qiu, Li-juan

Abstract

Flowering time is important for adaptation of soybean (Glycine max) to different environments. Here, we conducted a genome-wide association study of flowering time using a panel of 1490 cultivated soybean accessions. We identified three strong signals at the qFT02-2locus (Chr02: 12037319–12238569), which were associated with flowering time in three environments: Gongzhuling, Mengcheng, and Nanchang. By analyzing linkage disequilibrium, gene expression patterns, gene annotation, and the diversity of variants, we identified an AP1homolog as the candidate gene for the qFT02-2locus, which we named GmAP1d. Only one nonsynonymous polymorphism existed among 1490 soybean accessions at position Chr02:12087053. Accessions carrying the Chr02:12087053-T allele flowered significantly earlier than those carrying the Chr02:12087053-A allele. Thus, we developed a cleaved amplified polymorphic sequence (CAPS) marker for the SNP at Chr02:12087053, which is suitable for marker-assisted breeding of flowering time. Knockout of GmAP1din the ‘Williams 82’ background by gene editing promoted flowering under long-day conditions, confirming that GmAP1dis the causal gene for qFT02-2. An analysis of the region surrounding GmAP1drevealed that GmAP1dwas artificially selected during the genetic improvement of soybean. Through stepwise selection, the proportion of modern cultivars carrying the Chr02:12087053-T allele has increased, and this allele has become nearly fixed (95%) in northern China. These findings provide a theoretical basis for better understanding the molecular regulatory mechanism of flowering time in soybean and a target gene that can be used for breeding modern soybean cultivars adapted to different latitudes.

Published
2024
Full Text
View/download PDF

43. Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells

Author

Xu, Kailian, primary, Guo, Shiyu, additional, Zhao, Tianjing, additional, Zhu, Huapei, additional, Jiao, Hanwei, additional, Shi, Qiaoyun, additional, Pang, Feng, additional, Li, Yaying, additional, Li, Guohua, additional, Peng, Dongmei, additional, Nie, Xin, additional, Cheng, Ying, additional, Wu, Kebang, additional, Du, Li, additional, Cui, Ke, additional, Zhang, Wenguang, additional, and Wang, Fengyang, additional

Published
2016
Full Text
View/download PDF

44. Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway.

Author

Jin, Feng, Zhu, Guang, Li, Dan, Ni, Tengyang, Dai, Xiaojun, Wang, Haibo, Feng, Jun, Qian, Yayun, Yang, Lin, Guo, Shiyu, Hisamitsu, Tadashi, and Liu, Yanqing

Subjects
CELASTRUS orbiculatus, ETHYL acetate, ANTINEOPLASTIC agents, ALIMENTARY canal cancer, CANCER treatment, THERAPEUTICS
Abstract

Recently, Celastrus orbiculatus ethyl acetate extracts (COE) have been investigated for their anticancer effects on digestive tract tumors. However, the therapeutic effects of COE on esophageal squamous carcinoma cells (ESCC) have not been investigated. In the present study, the effects of COE on the cell cycle and apoptosis of ESCCs were assessed in vitro, and it was revealed that COE treatment triggered G0/G1 cell cycle arrest, and induced DNA damage and apoptosis in a dose-dependent manner in ESCC. Activation of the phosphatidylinositol 3-kinase/protein kinase-B/mechanistic target of rapamycin (mTOR) pathway was also suppressed by COE. Additionally, the combined treatment with COE and rapamycin (an mTOR inhibitor) acted synergistically in ECA-109 cells compared with the treatment with COE or rapamycin alone. These findings extend the understanding of the action of COE and suggest that COE has potential as a treatment option for ESCC as a single treatment or in combination. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results