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Abstract The purpose of this study was to investigate the relationship between circulating cytokines and liver function and prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with radiotherapy combined with tislelizumab and anlotinib. The liver function indexes and pre-treatment levels of cytokines in 47 patients were measured by chemical method and flow cytometry. The median follow-up was 23.1 months. The objective response and the disease control rates were 46.8% and 68.1%, while overall survival (OS) and progression-free survival (PFS) were 12.6 and 11.4 months, respectively. Adverse events (2.1%) were grade 3–4. In addition to stage, intrahepatic metastasis and Child–Pugh score, pre-treatment interleukin-6 (IL-6) was the main cytokine affecting OS and PFS (p

C13H16O6, monoclinic, P21/c (no. 14), a = 12.180(3) Å, b = 13.813(4) Å, c = 7.842(2) Å, β = 93.917(4)°, V = 1316.2(6) Å3, Z = 4, Rgt(F) = 0.0442, wRref(F2) = 0.1375, T = 296(2) K.

The unconsolidated sandstone in hydrothermal geothermal field in Jianghan basin is taken as the research object. The hydrostatic pressure is applied to a geostress equal to 12.5 MPa. After the deformation of sample is stabilised, the evolution and mechanism of the permeability of unconsolidated sandstone under the compaction of high hydrostatic pressure are studied, which can provide some suggestions for the selection of equipment operating parameters for the tailwater recharge process in the hydrothermal geothermal field. The results indicate that under high hydrostatic pressure compaction, the permeability of unconsolidated sandstone samples tends to be a constant valued of 4.0×103 m2 within the current range of 0.5 mL/min to 3.0 mL/min. The pressure difference between the two ends of the sample increases nonlinearly with time and the degree of nonlinearity gradually increases with the increase of flow rate, but eventually tends to be stabilised. In addition, the sample of unconsolidated sandstone forms a tubular erosion channel in the direction of penetration, extending to about 2/3 of the sample. Based on the stop time of particle transportation and the extension length of tubular erosion channel in the penetration direction, the average migration velocities of particles under different flow rates are determined. It is found that the particle migration velocity increases exponentially with the increase of flow rate, and the amount of microparticle migrated per unit time increases. When the pressure difference exceeds about 1/2 of the hydrostatic pressure, the sample presents erosion damage and upstream diameter shrinkage.

Objective To investigate the influence of body mass index (BMI) and abdominal girth index (AGI) on the location and etiology of ischemic stroke in order to determine whether they can predict the etiology and pathogenesis of ischemic stroke. Methods A total of 185 patients with acute ischemic stroke and 155 cases of normal controls matched in sex, age and past medical history were enrolled in this study. Their height and weight were measured to calculate BMI, and abdominal circumference was measured to calculate AGI. Oxfordshire Community Stroke Project (OCSP) and TOAST classification were carried out. Results BMI of overweight (BMI 24.00-27.90 kg/m2) subgroup (t = 2.060, P = 0.000) and obesity (BMI ≥ 28 kg/m2) subgroup (t = 2.315, P = 0.000) in patients with ischemic stroke was significantly higher than that in control group. AGI of abnomaly (AGI > 1 cm/kg) subgroup in patients with ischemic stroke was significantly higher than that in control group (t = 1.021, P = 0.000). Based on OCSP classification, 185 patients with ischemic stroke were classified into 10 (5.41%) of total anterior circulation infarct (TACI), 81 (43.78%) of partial anterior circulation infarct (PACI), 56 (30.27%) of lacunar infarct (LACI) and 38 (20.54%) of posterior circulation infarct (POCI). Only the PACI ratio among different BMI subgroups had statistical significance (H = 7.041, P = 0.011). PACI ratio in BMI 24.00-27.90 kg/m2 subgroup was significantly higher than that in BMI < 18.50 kg/m2 subgroup (Z = 4.823, P = 0.028), 18.50-23.90 kg/m2 subgroup (Z = 3.157, P = 0.026) and ≥ 28 kg/m2 subgroup (Z = 2.076, P = 0.015). In AGI subgroups, only POCI ratio in AGI ＞1 cm/kg subgroup was significantly higher than that in AGI ≤ 1 cm/kg subgroup (χ2 = 6.624, P = 0.010). In TOAST classification, 185 patients with ischemic stroke were classified into 59 (31.89%) of large artery atherosclerosis (LAA), 57 (30.81%) of small artery occlusion (SAO), 32 (17.30%) of cardioembolism (CE), 17 (9.19%) of stroke of other determined etiology (SOE) and 20 (10.81%) of stroke of undetermined etiology (SUE). LAA ratio (H = 21.597, P = 0.000) and SAO ratio (H = 29.908, P = 0.000) among different BMI subgroups had statistical significance. LAA ratio in BMI ≥ 28 kg/m2 subgroup was significantly higher than that in < 18.50 kg/m2 subgroup (Z = 9.263, P = 0.020), 18.50-23.90 kg/m2 subgroup (Z = 18.780, P = 0.000) and 24.00-27.90 kg/m2 subgroup (Z = 6.817, P = 0.009). SAO ratio in BMI 18.50-23.90 kg/m2 subgroup was significantly higher than that in < 18.50 kg/m2 subgroup (Z = 7.404, P = 0.007), 24.00-27.90 kg/m2 subgroup (Z = 22.849, P = 0.000) and ≥ 28 kg/m2 subgroup (Z = 12.025, P = 0.001). In AGI subgroups, LAA ratio in > 1 cm/kg subgroup was significantly higher (χ2 = 11.461, P = 0.001), while SOE ratio was significantly lower ( χ2 = 4.558, P = 0.033) than that in AGI ≤ 1 cm/kg subgroup. Conclusions BMI and AGI can influence the location and etiology of ischemic stroke, which can be used to predict the etiology and pathogenesis of ischemic stroke. DOI: 10.3969/j.issn.1672-6731.2017.11.011

The Permian Baima mafic layered intrusion, believed to be related to the S-undersaturated Emeishan high-Ti basalts, hosts a giant Fe-Ti-V oxide deposit in the lower part of the intrusion. Uniformly high Cu/Pd (1.9 x [10.sup.6]-6.1 x [10.sup.4]) and low Pd/Zr ( Keywords Emeishan large igneous province * Panxi area * Layered intrusion * High-Ti basalts * Chalcophile elements * Sulfide saturation, Introduction Large layered intrusions commonly host reef-type platinum-group element (PGE) mineralization, including the Merensky Reef, UG1 and UG2 Reefs in the Bushveld Complex and the J-M Reef in the Stillwater [...]

C13H16O6, monoclinic, P21/c (no. 14), a = 12.180(3) Å, b = 13.813(4) Å, c = 7.842(2) Å, β = 93.917(4)°, V = 1316.2(6) Å3, Z = 4, Rgt(F) = 0.0442, wRref(F2) = 0.1375, T = 296(2) K. [ABSTRACT FROM AUTHOR]

C12H12O4, monoclinic, P21/c (no. 14), a = 16.071(6) Å, b = 9.424(4) Å, c = 7.640(3) Å, β = 101.861(5)°, V = 1132.4(8) Å3, Z = 4, Rgt(F) = 0.0366, wRref(F2) = 0.1043, T = 296(2) K. [ABSTRACT FROM AUTHOR]

Cerebral ischemia reperfusion (CIR) is one of the highly lethal diseases in the world. MicroRNA‐370 (miR‐370) exerts multiple functions in different diseases. However, further research is needed to investigate the potential role of miR‐370 in CIR injury. The in vivo middle cerebral artery occlusion (MCAO) rat model and in vitro oxygen‐glucose deprivation/reoxygenation (OGD/R) SH‐SY5Y cell model were successfully established to mimic CIR injury. The infarct sizes of brain tissues from rats were evaluated. The relationship between miR‐370 and silencing information regulatory protein 6 (SIRT6) was confirmed by luciferase activity assay. The cell viability and apoptosis were determined by CCK‐8 assay and terminal‐deoxynucleoitidyl transferase mediated nick end labeling staining. In this study, miR‐370 was upregulated in brain tissues of MCAO rats and knockdown of miR‐370 decreased cerebral infarction volume of MCAO rats and it alleviated CIR injury in vivo. The in vitro experiments indicated that knockdown of miR‐370 promoted cell viability and alleviated OGD/R‐induced SH‐SY5Y cell apoptosis. Additionally, the TargetScan predicted that SIRT6 was a target of miR‐370 and confirmed by luciferase activity assay. Moreover, miR‐370 inhibited SIRT6 expression and regulated Nrf2/ARE signal pathway, whereas overexpression of SIRT6 partly reversed the effect of miR‐370 on OGD/R‐induced SH‐SY5Y cell injury. Thus, we could conclude that miR‐370 accelerated CIR injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway, which might provide novel therapeutic targets for CIR injury treatment. [ABSTRACT FROM AUTHOR]

Byline: Li. Gui, Gui-Shu. Shi, Guang-Jian. Li, Wen-Hui. Fan, He-Qing. Huang, Zheng-Hua. Zhou, Kang-Ning. Chen Background and Objectives: Spontaneous vertebral artery dissection (sVAD) is a rare condition and can potentially [...]

Objective To investigate the influence of body mass index (BMI) and abdominal girth index (AGI) on the location and etiology of ischemic stroke in order to determine whether they can predict the etiology and pathogenesis of ischemic stroke. Methods A total of 185 patients with acute ischemic stroke and 155 cases of normal controls matched in sex, age and past medical history were enrolled in this study. Their height and weight were measured to calculate BMI, and abdominal circumference was measured to calculate AGI. Oxfordshire Community Stroke Project (OCSP) and TOAST classification were carried out. Results BMI of overweight (BMI 24.00-27.90 kg/m²) subgroup (t = 2.060, P = 0.000) and obesity (BMI ≥ 28 kg/m²) subgroup (t = 2.315, P = 0.000) in patients with ischemic stroke was significantly higher than that in control group. AGI of abnomaly (AGI > 1 cm/kg) subgroup in patients with ischemic stroke was significantly higher than that in control group (t = 1.021, P = 0.000). Based on OCSP classification, 185 patients with ischemic stroke were classified into 10 (5.41%) of total anterior circulation infarct (TACI), 81 (43.78%) of partial anterior circulation infarct (PACI), 56 (30.27%) of lacunar infarct (LACI) and 38 (20.54%) of posterior circulation infarct (POCI). Only the PACI ratio among different BMI subgroups had statistical significance (H = 7.041, P = 0.011). PACI ratio in BMI 24.00-27.90 kg/m² subgroup was significantly higher than that in BMI < 18.50 kg/m² subgroup (Z = 4.823, P = 0.028), 18.50-23.90 kg/m² subgroup (Z = 3.157, P = 0.026) and ≥ 28 kg/m² subgroup (Z = 2.076, P = 0.015). In AGI subgroups, only POCI ratio in AGI >1 cm/kg subgroup was significantly higher than that in AGI ≤ 1 cm/kg subgroup (χ² = 6.624, P = 0.010). In TOAST classification, 185 patients with ischemic stroke were classified into 59 (31.89%) of large artery atherosclerosis (LAA), 57 (30.81%) of small artery occlusion (SAO), 32 (17.30%) of cardioembolism (CE), 17 (9.19%) of stroke of other determined etiology (SOE) and 20 (10.81%) of stroke of undetermined etiology (SUE). LAA ratio (H = 21.597, P = 0.000) and SAO ratio (H = 29.908, P = 0.000) among different BMI subgroups had statistical significance. LAA ratio in BMI ≥ 28 kg/m² subgroup was significantly higher than that in < 18.50 kg/m² subgroup (Z = 9.263, P = 0.020), 18.50-23.90 kg/m² subgroup (Z = 18.780, P = 0.000) and 24.00-27.90 kg/m² subgroup (Z = 6.817, P = 0.009). SAO ratio in BMI 18.50-23.90 kg/m² subgroup was significantly higher than that in < 18.50 kg/m² subgroup (Z = 7.404, P = 0.007), 24.00-27.90 kg/m² subgroup (Z = 22.849, P = 0.000) and ≥ 28 kg/m² subgroup (Z = 12.025, P = 0.001). In AGI subgroups, LAA ratio in > 1 cm/kg subgroup was significantly higher ( χ² = 11.461, P = 0.001), while SOE ratio was significantly lower ( χ²= 4.558, P = 0.033) than that in AGI ≤ 1 cm/kg subgroup. Conclusions BMI and AGI can influence the location and etiology of ischemic stroke, which can be used to predict the etiology and pathogenesis of ischemic stroke. [ABSTRACT FROM AUTHOR]