Search

Your search keyword '"Guadalupi, Livia"' showing total 21 results
Start Over Author "Guadalupi, Livia" Search Limiters Full Text
21 results on '"Guadalupi, Livia"'

1. Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis

Author

Guadalupi, Livia, Vanni, Valentina, Balletta, Sara, Caioli, Silvia, De Vito, Francesca, Fresegna, Diego, Sanna, Krizia, Nencini, Monica, Donninelli, Gloria, Volpe, Elisabetta, Mariani, Fabrizio, Battistini, Luca, Stampanoni Bassi, Mario, Gilio, Luana, Bruno, Antonio, Dolcetti, Ettore, Buttari, Fabio, Mandolesi, Georgia, Centonze, Diego, and Musella, Alessandra

Published
2024
Full Text
View/download PDF

2. Re-emergence of T lymphocyte-mediated synaptopathy in progressive multiple sclerosis

Author

Sanna, Krizia, primary, Bruno, Antonio, additional, Balletta, Sara, additional, Caioli, Silvia, additional, Nencini, Monica, additional, Fresegna, Diego, additional, Guadalupi, Livia, additional, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Buttari, Fabio, additional, Fantozzi, Roberta, additional, Borrelli, Angela, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Lauritano, Gianluca, additional, Vanni, Valentina, additional, De Vito, Francesca, additional, Tartacca, Alice, additional, Mariani, Fabrizio, additional, Rovella, Valentina, additional, Musella, Alessandra, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2024
Full Text
View/download PDF

3. Interleukin-10 contrasts inflammatory synaptopathy and central neurodegenerative damage in multiple sclerosis.

Author

Gilio, Luana, Fresegna, Diego, Bassi, Mario Stampanoni, Musella, Alessandra, De Vito, Francesca, Balletta, Sara, Sanna, Krizia, Caioli, Silvia, Pavone, Luigi, Galifi, Giovanni, Simonelli, Ilaria, Guadalupi, Livia, Vanni, Valentina, Buttari, Fabio, Dolcetti, Ettore, Bruno, Antonio, Azzolini, Federica, Borrelli, Angela, Fantozzi, Roberta, and Finardi, Annamaria

Subjects
MEDIUM spiny neurons, INTERLEUKIN-10, BRAIN anatomy, LABORATORY mice, MULTIPLE sclerosis, NEURAL transmission
Abstract

Proinflammatory cytokines are implicated in promoting neurodegeneration in multiple sclerosis (MS) by affecting excitatory and inhibitory transmission at central synapses. Conversely, the synaptic effects of anti-inflammatory molecules remain underexplored, despite their potential neuroprotective properties and their presence in the cerebrospinal fluid (CSF) of patients. In a study involving 184 newly diagnosed relapsing-remitting (RR)-MS patients, we investigated whether CSF levels of the anti-inflammatory interleukin (IL)-10 were linked to disease severity and neurodegeneration measures. Additionally, we examined IL-10 impact on synaptic transmission in striatal medium spiny neurons and its role in counteracting inflammatory synaptopathy induced by IL-1β in female C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Our findings revealed a significant positive correlation between IL-10 CSF levels and changes in EDSS (Expanded Disability Status Scale) scores one year after MS diagnosis. Moreover, IL-10 levels in the CSF were positively correlated with volumes of specific subcortical brain structures, such as the nucleus caudate. In both MS patients' CSF and EAE mice striatum, IL-10 and IL-1β expressions were upregulated, suggesting possible antagonistic effects of these cytokines. Notably, IL-10 exhibited the ability to decrease glutamate transmission, increase GABA transmission in the striatum, and reverse IL-1β-induced abnormal synaptic transmission in EAE. In conclusion, our data suggest that IL-10 exerts direct neuroprotective effects in MS patients by modulating both excitatory and inhibitory transmission and attenuating IL-1β-induced inflammatory synaptopathy. These findings underscore the potential therapeutic significance of IL-10 in mitigating neurodegeneration in MS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Re-emergence of T lymphocytemediated synaptopathy in progressive multiple sclerosis.

Author

Sanna, Krizia, Bruno, Antonio, Balletta, Sara, Caioli, Silvia, Nencini, Monica, Fresegna, Diego, Guadalupi, Livia, Dolcetti, Ettore, Azzolini, Federica, Buttari, Fabio, Fantozzi, Roberta, Borrelli, Angela, Bassi, Mario Stampanoni, Gilio, Luana, Lauritano, Gianluca, Vanni, Valentina, De Vito, Francesca, Tartacca, Alice, Mariani, Fabrizio, and Rovella, Valentina

Subjects
MULTIPLE sclerosis, T cells, NEURAL transmission, DISEASE relapse, SYNAPSES
Abstract

Background: Secondary progressive multiple sclerosis (SPMS) is defined by the irreversible accumulation of disability following a relapsing-remitting MS (RRMS) course. Despite treatments advances, a reliable tool able to capture the transition from RRMS to SPMS is lacking. A T cell chimeric MS model demonstrated that T cells derived from relapsing patients exacerbate excitatory transmission of central neurons, a synaptotoxic event absent during remitting stages. We hypothesized the re-emergence of T cell synaptotoxicity during SPMS and investigated the synaptoprotective effects of siponimod, a sphingosine 1-phosphate receptor (S1PR) modulator, known to reduce grey matter damage in SPMS patients. Methods: Data from healthy controls (HC), SPMS patients, and siponimod-treated SPMS patients were collected. Chimeric experiments were performed incubating human T cells on murine cortico-striatal slices, and recording spontaneous glutamatergic activity from striatal neurons. Homologous chimeric experiments were executed incubating EAE mice T cells with siponimod and specific S1PR agonists or antagonists to identify the receptor involved in siponimod-mediated synaptic recovery. Results: SPMS patient-derived T cells significantly increased the striatal excitatory synaptic transmission (n=40 synapses) compared to HC T cells (n=55 synapses), mimicking the glutamatergic alterations observed in active RRMS-T cells. Siponimod treatment rescued SPMS T cells synaptotoxicity (n=51 synapses). Homologous chimeric experiments highlighted S1P5R involvement in the siponimod’s protective effects. Conclusion: Transition from RRMS to SPMS involves the reappearance of T cell-mediated synaptotoxicity. Siponimod counteracts T cell-induced excitotoxicity, emphasizing the significance of inflammatory synaptopathy in progressive MS and its potential as a promising pharmacological target. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis

Author

De Vito, Francesca, primary, Balletta, Sara, additional, Caioli, Silvia, additional, Musella, Alessandra, additional, Guadalupi, Livia, additional, Vanni, Valentina, additional, Fresegna, Diego, additional, Bassi, Mario Stampanoni, additional, Gilio, Luana, additional, Sanna, Krizia, additional, Gentile, Antonietta, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Buttari, Fabio, additional, Pavone, Luigi, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Perlas, Emerald, additional, Hornstein, Eran, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2023
Full Text
View/download PDF

6. Low-contrast visual acuity test is associated with central inflammation and predicts disability development in newly diagnosed multiple sclerosis patients.

Author

Dolcetti, Ettore, Buttari, Fabio, Bruno, Antonio, Azzolini, Federica, Gilio, Luana, Di Caprio, Veronica, Lauritano, Gianluca, Borrelli, Angela, Galifi, Giovanni, Furlan, Roberto, Finardi, Annamaria, Musella, Alessandra, Guadalupi, Livia, Mandolesi, Georgia, Rovella, Valentina, Centonze, Diego, and Bassi, Mario Stampanoni

Subjects
VISUAL acuity, MULTIPLE sclerosis, VISUAL evoked potentials, VISION disorders, DISABILITIES, LOW vision
Abstract

Introduction: The visual system is a prominent site of damage in MS since the earliest phases of the disease. Altered low-contrast visual acuity (LCVA) test has been associated with visual impairment and retinal degeneration, predicting medium- and long-term disability. However, it is unclear whether LCVA may also represent a reliable measure of neuroinflammation and a predictor of disease evolution in the very early stages of MS. Methods: We explored in a group of 76 consecutive newly diagnosed relapsing-- remitting MS (RR-MS) patients without visual impairment or altered visual evoked potentials, the association between LCVA scores at 2.5% and 1.25% and clinical characteristics, including prospective disability evaluated after 1- and 2 years of follow-up. Associations between LCVA and the CSF levels of IL-10 at diagnosis were also analyzed. Results: A negative correlation was found between LCVA at 2.5% and Expanded Disability Status Scale (EDSS) evaluated at first (Spearman's Rho= -0.349, p =0.005, n =62) and second year (Spearman's Rho= -0.418, p <0.001, n =62) of follow-up, and negative correlations were found with Multiple Sclerosis Severity Score (MSSS) at first (Spearman's Rho= -0.359, p =0.004, n =62) and second year (Spearman's Rho= -0.472, p <0.001, n=62). All the data were confirmed by a mixed effect model, considering other clinical variables. A positive correlation was found between the CSF concentrations of IL-10 and LCVA at 2.5% (Spearman's Rho=0.272, p =0.020, n =76), and 1.25% (Spearman's Rho, = 0.276, p =0.018, n=76), also evidenced in a linear regression. Discussion: In MS patients at diagnosis, altered LCVA may be associated with CSF inflammation and represent a useful parameter to identify patients with worse disease course. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Preventive exercise attenuates IL-2-driven mood disorders in multiple sclerosis

Author

Gilio, Luana, primary, Fresegna, Diego, additional, Gentile, Antonietta, additional, Guadalupi, Livia, additional, Sanna, Krizia, additional, De Vito, Francesca, additional, Balletta, Sara, additional, Caioli, Silvia, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Iezzi, Ennio, additional, Moscatelli, Alessandro, additional, Galifi, Giovanni, additional, Fantozzi, Roberta, additional, Bellantonio, Paolo, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Vanni, Valentina, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

8. Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Moscatelli, Alessandro, additional, Gambardella, Stefano, additional, Ferese, Rosangela, additional, Rizzo, Francesca Romana, additional, Gilio, Luana, additional, Iezzi, Ennio, additional, Galifi, Giovanni, additional, Borrelli, Angela, additional, Buttari, Fabio, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, De Vito, Francesca, additional, Musella, Alessandra, additional, Guadalupi, Livia, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

9. The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis

Author

Dolcetti, Ettore, primary, Bruno, Antonio, additional, Azzolini, Federica, additional, Gilio, Luana, additional, Moscatelli, Alessandro, additional, De Vito, Francesca, additional, Pavone, Luigi, additional, Iezzi, Ennio, additional, Gambardella, Stefano, additional, Giardina, Emiliano, additional, Ferese, Rosangela, additional, Buttari, Fabio, additional, Rizzo, Francesca Romana, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Guadalupi, Livia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

10. Neuroinflammation Is Associated with GFAP and sTREM2 Levels in Multiple Sclerosis

Author

Azzolini, Federica, primary, Gilio, Luana, additional, Pavone, Luigi, additional, Iezzi, Ennio, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Guadalupi, Livia, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Micillo, Teresa, additional, Carbone, Fortunata, additional, Matarese, Giuseppe, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

11. The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis

Author

Mandolesi, Georgia, primary, Rizzo, Francesca Romana, additional, Balletta, Sara, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Guadalupi, Livia, additional, Nencini, Monica, additional, Moscatelli, Alessandro, additional, Ryan, Colleen Patricia, additional, Licursi, Valerio, additional, Dolcetti, Ettore, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, Fresegna, Diego, additional, Bullitta, Silvia, additional, Caioli, Silvia, additional, Vanni, Valentina, additional, Sanna, Krizia, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Castelli, Chiara, additional, Presutti, Carlo, additional, De Santa, Francesca, additional, Finardi, Annamaria, additional, Furlan, Roberto, additional, Centonze, Diego, additional, and De Vito, Francesca, additional

Published
2021
Full Text
View/download PDF

12. Corrigendum: Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2021
Full Text
View/download PDF

13. Re-Examining the Role of TNF in MS Pathogenesis and Therapy

Author

Fresegna, Diego, primary, Bullitta, Silvia, additional, Musella, Alessandra, additional, Rizzo, Francesca Romana, additional, De Vito, Francesca, additional, Guadalupi, Livia, additional, Caioli, Silvia, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Dolcetti, Ettore, additional, Vanni, Valentina, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Gentile, Antonietta, additional

Published
2020
Full Text
View/download PDF

14. Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis

Author

Dolcetti, Ettore, primary, Bruno, Antonio, additional, Guadalupi, Livia, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Bullitta, Silvia, additional, Fresegna, Diego, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

15. Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

16. Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis

Author

Musella, Alessandra, primary, Gentile, Antonietta, additional, Guadalupi, Livia, additional, Rizzo, Francesca Romana, additional, De Vito, Francesca, additional, Fresegna, Diego, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Vanni, Valentina, additional, Vitiello, Laura, additional, Bullitta, Silvia, additional, Sanna, Krizia, additional, Caioli, Silvia, additional, Balletta, Sara, additional, Nencini, Monica, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

17. Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

Author

Rizzo, Francesca Romana, Musella, Alessandra, De Vito, Francesca, Fresegna, Diego, Bullitta, Silvia, Vanni, Valentina, Guadalupi, Livia, Stampanoni Bassi, Mario, Buttari, Fabio, Mandolesi, Georgia, Centonze, Diego, and Gentile, Antonietta

Subjects
Article Subject
Abstract

Cytokines are constitutively released in the healthy brain by resident myeloid cells to keep proper synaptic plasticity, either in the form of Hebbian synaptic plasticity or of homeostatic plasticity. However, when cytokines dramatically increase, establishing a status of neuroinflammation, the synaptic action of such molecules remarkably interferes with brain circuits of learning and cognition and contributes to excitotoxicity and neurodegeneration. Among others, interleukin-1β (IL-1β) and tumor necrosis factor (TNF) are the best studied proinflammatory cytokines in both physiological and pathological conditions and have been invariably associated with long-term potentiation (LTP) (Hebbian synaptic plasticity) and synaptic scaling (homeostatic plasticity), respectively. Multiple sclerosis (MS) is the prototypical neuroinflammatory disease, in which inflammation triggers excitotoxic mechanisms contributing to neurodegeneration. IL-β and TNF are increased in the brain of MS patients and contribute to induce the changes in synaptic plasticity occurring in MS patients and its animal model, the experimental autoimmune encephalomyelitis (EAE). This review will introduce and discuss current evidence of the role of IL-1β and TNF in the regulation of synaptic strength at both physiological and pathological levels, in particular speculating on their involvement in the synaptic plasticity changes observed in the EAE brain.

Published
2018
Full Text
View/download PDF

18. Immunomodulatory Effects of Exercise in Experimental Multiple Sclerosis

Author

Gentile, Antonietta, primary, Musella, Alessandra, additional, De Vito, Francesca, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Guadalupi, Livia, additional, Stampanoni Bassi, Mario, additional, Buttari, Fabio, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2019
Full Text
View/download PDF

19. Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis

Author

Stampanoni Bassi, Mario, primary, Gentile, Antonietta, additional, Iezzi, Ennio, additional, Zagaglia, Sara, additional, Musella, Alessandra, additional, Simonelli, Ilaria, additional, Gilio, Luana, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Marfia, Girolama A., additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Buttari, Fabio, additional

Published
2019
Full Text
View/download PDF

20. Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions

Author

Musella, Alessandra, primary, Gentile, Antonietta, additional, Rizzo, Francesca Romana, additional, De Vito, Francesca, additional, Fresegna, Diego, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Guadalupi, Livia, additional, Stampanoni Bassi, Mario, additional, Buttari, Fabio, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2018
Full Text
View/download PDF

21. BACE1 influences clinical manifestations and central inflammation in relapsing remitting multiple sclerosis

Author

Bruno, A, Dolcetti, E, Azzolini, F, Buttari, F, Gilio, L, Iezzi, E, Galifi, G, Borrelli, A, Furlan, R, Finardi, A, Carbone, F, De Vito, F, Musella, A, Guadalupi, L, Mandolesi, G, Matarese, G, Centonze, D, Stampanoni Bassi, M, Bruno, Antonio, Dolcetti, Ettore, Azzolini, Federica, Buttari, Fabio, Gilio, Luana, Iezzi, Ennio, Galifi, Giovanni, Borrelli, Angela, Furlan, Roberto, Finardi, Annamaria, Carbone, Fortunata, De Vito, Francesca, Musella, Alessandra, Guadalupi, Livia, Mandolesi, Georgia, Matarese, Giuseppe, Centonze, Diego, and Stampanoni Bassi, Mario

Subjects
Multiple sclerosis, Neurodegeneration, CSF, Neurology, Neuroinflammation, CSF, BACE1, Multiple sclerosi, Neurology (clinical), General Medicine, Neurodegeneration, Settore MED/26
Abstract

Neurodegenerative and inflammatory processes influence the clinical course of multiple sclerosis (MS). The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has been associated with cognitive dysfunction, amyloid deposition and neuroinflammation in Alzheimer's disease. We explored in a group of 50 patients with relapsing-remitting MS the association between the cerebrospinal fluid (CSF) levels of BACE1, clinical characteristics at the time of diagnosis and prospective disability after three-years follow-up. In addition, we assessed the correlations between the CSF levels of BACE 1, amyloid β (Aβ) 1-40 and 1-42, phosphorylated tau (pTau), lactate, and a set of inflammatory and anti-inflammatory molecules. BACE1 CSF levels were correlated positively with depression as measured with Beck Depression Inventory-Second Edition scale, and negatively with visuospatial memory performance evaluated by the Brief Visuospatial Memory Test-Revised. In addition, BACE CSF levels were positively correlated with Bayesian Risk Estimate for MS at onset, and with Expanded Disability Status Scale score assessed three years after diagnosis. Furthermore, a positive correlation was found between BACE1, amyloid β 42/40 ratio (Spearman's r = 0.334, p = 0.018, n = 50), pTau (Spearman's r = 0.304, p = 0.032, n = 50) and lactate concentrations (Spearman's r = 0.361, p = 0.01, n = 50). Finally, an association emerged between BACE1 CSF levels and a group of pro and anti-inflammatory molecules, including interleukin (IL)-4, IL-17, IL-13, IL-9 and interferon-γ. BACE1 may have a role in different key mechanisms such as neurodegeneration, oxidative stress and inflammation, influencing mood, cognitive disorders and disability progression in MS.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results