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Objective Combining text mining (TM) and clinical decision support (CDS) could improve diagnostic and therapeutic processes in clinical practice. This review summarizes current knowledge of the TM-CDS combination in clinical practice, including their intended purpose, implementation in clinical practice, and barriers to such implementation. Materials and Methods A search was conducted in PubMed, EMBASE, and Cochrane Library databases to identify full-text English language studies published before January 2022 with TM-CDS combination in clinical practice. Results Of 714 identified and screened unique publications, 39 were included. The majority of the included studies are related to diagnosis (n  =   26) or prognosis (n  =   11) and used a method that was developed for a specific clinical domain, document type, or application. Most of the studies selected text containing parts of the electronic health record (EHR), such as reports (41%, n  =   16) and free-text narratives (36%, n  =   14), and 23 studies utilized a tool that had software "developed for the study". In 15 studies, the software source was openly available. In 79% of studies, the tool was not implemented in clinical practice. Barriers to implement these tools included the complexity of natural language, EHR incompleteness, validation and performance of the tool, lack of input from an expert team, and the adoption rate among professionals. Discussion/Conclusions The available evidence indicates that the TM-CDS combination may improve diagnostic and therapeutic processes, contributing to increased patient safety. However, further research is needed to identify barriers to implementation and the impact of such tools in clinical practice. [ABSTRACT FROM AUTHOR]

Objective: Adverse drug reactions (ADRs) are a significant healthcare concern. They are often documented as free text in electronic health records (EHRs), making them challenging to use in clinical decision support systems (CDSS). The study aimed to develop a text mining algorithm to identify ADRs in free text of Dutch EHRs., Materials and Methods: In Phase I, our previously developed CDSS algorithm was recoded and improved upon with the same relatively large dataset of 35 000 notes (Step A), using R to identify possible ADRs with Medical Dictionary for Regulatory Activities (MedDRA) terms and the related Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) (Step B). In Phase II, 6 existing text-mining R-scripts were used to detect and present unique ADRs, and positive predictive value (PPV) and sensitivity were observed., Results: In Phase IA, the recoded algorithm performed better than the previously developed CDSS algorithm, resulting in a PPV of 13% and a sensitivity of 93%. For The sensitivity for serious ADRs was 95%. The algorithm identified 58 additional possible ADRs. In Phase IB, the algorithm achieved a PPV of 10%, a sensitivity of 86%, and an F-measure of 0.18. In Phase II, four R-scripts enhanced the sensitivity and PPV of the algorithm, resulting in a PPV of 70%, a sensitivity of 73%, an F-measure of 0.71, and a 63% sensitivity for serious ADRs., Discussion and Conclusion: The recoded Dutch algorithm effectively identifies ADRs from free-text Dutch EHRs using R-scripts and MedDRA/SNOMED-CT. The study details its limitations, highlighting the algorithm's potential and significant improvements., Competing Interests: The authors have no competing interests to declare., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association.)

Objective: Combining text mining (TM) and clinical decision support (CDS) could improve diagnostic and therapeutic processes in clinical practice. This review summarizes current knowledge of the TM-CDS combination in clinical practice, including their intended purpose, implementation in clinical practice, and barriers to such implementation., Materials and Methods: A search was conducted in PubMed, EMBASE, and Cochrane Library databases to identify full-text English language studies published before January 2022 with TM-CDS combination in clinical practice., Results: Of 714 identified and screened unique publications, 39 were included. The majority of the included studies are related to diagnosis (n = 26) or prognosis (n = 11) and used a method that was developed for a specific clinical domain, document type, or application. Most of the studies selected text containing parts of the electronic health record (EHR), such as reports (41%, n = 16) and free-text narratives (36%, n = 14), and 23 studies utilized a tool that had software "developed for the study". In 15 studies, the software source was openly available. In 79% of studies, the tool was not implemented in clinical practice. Barriers to implement these tools included the complexity of natural language, EHR incompleteness, validation and performance of the tool, lack of input from an expert team, and the adoption rate among professionals., Discussion/conclusions: The available evidence indicates that the TM-CDS combination may improve diagnostic and therapeutic processes, contributing to increased patient safety. However, further research is needed to identify barriers to implementation and the impact of such tools in clinical practice., (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)