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8. Introduction a l'analyse genetique

Author

B., G., primary, Griffiths, Anthony J. F., additional, Miller, Jeffrey H., additional, Suzuki, David T., additional, Lewontin, Richard C., additional, and Gelbart, William M., additional

Published
1999
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11. Ultrastructural changes in Neurospora cells undergoing senescence induced by kalilo plasmids.

Author

Jin-Woo Bok, Ishida, Ken-Ichiro, and Griffiths, Anthony J. F.

Subjects
CELL death, CELLULAR aging, NEUROSPORA, DNA, APOPTOSIS
Abstract

Discusses a study that investigated cell death pathway using the ultrastructural changes and internucleosomal DNA fragmentation patterns of senescing kalilo strains of Neurospora. Occurrence of cell death in multicellular organisms; Features of apoptosis; Analysis of DNA fragmentation.

Published
2003
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12. Ultrastructural changes in Neurosporacells undergoing senescence induced by kalilo plasmids

Author

Bok, Jin-Woo, Ishida, Ken-Ichiro, and Griffiths, Anthony J. F.

Abstract

In N. crassaand N. intermedia, the kalilo plasmid triggers senescence by insertion into mitochondrial DNA. To investigate the cell death pathway induced by this plasmid, juvenile and senescent subcultures of several senescent strains were examined by light and transmission electron microscopy, and at the DNA level. There were no signs of apoptotic events, such as shrinkage of the cytoplasm away from the cell wall, apoptotic bodies, internucleosomal DNA fragmentation or condensation of the cytoplasm while retaining mitochondria and endomembrane structure. Instead, swollen mitochondria lacking cristae and containing amorphous inclusions, and disruption of nuclear and mitochondrial membranes indicated a necrotic mode of cell death.

Published
2004
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