Search

Your search keyword '"Grall-Jezequel A"' showing total 10 results
Start Over Author "Grall-Jezequel A" Search Limiters Full Text
10 results on '"Grall-Jezequel A"'

1. Alveolar echinococcosis in solid organ transplant recipients: a case series from two national cohorts

Author

Marquis Bastian, Demonmerot Florent, Richou Carine, Thiéfin Gérard, Millon Laurence, Wallon Martine, Vuitton Dominique Angèle, Grall-Jezequel Anne, Grenouillet Frédéric, Epaulard Olivier, Gervais Philippe, Manuel Oriol, and Bresson-Hadni Solange

Subjects
solid-organ transplant, alveolar echinococcosis, echinococcus multilocularis, immunosuppression, Infectious and parasitic diseases, RC109-216
Abstract

Alveolar echinococcosis (AE) is a severe parasitic infection caused by the ingestion of Echinococcus multilocularis eggs. While higher incidence and faster evolution have been reported in immunosuppressed patients, no studies have been performed specifically on AE in transplant patients. We searched for all de novo AE cases diagnosed between January 2008 and August 2018 in solid organ transplant (SOT) recipients included in the Swiss Transplant Cohort Study and the FrancEchino Registry. Eight cases were identified (kidney = 5, lung = 2, heart = 1, liver = 0), half of which were asymptomatic at diagnosis. AE diagnosis was difficult due to the low sensitivity (60%) of the standard screening serology (Em2+) and the frequently atypical radiological presentations. Conversely, Echinococcus Western blot retained good diagnostic performances and was positive in all eight cases. Five patients underwent surgery, but complete resection could only be achieved in one case. Moreover, two patients died of peri-operative complications. Albendazole was initiated in seven patients and was well tolerated. Overall, AE regressed in one, stabilized in three, and progressed in one case, and had an overall mortality of 37.5% (3/8 patients). Our data suggest that AE has a higher mortality and a faster clinical course in SOT recipients; they also suggest that the parasitic disease might be due to the reactivation of latent microscopic liver lesions through immune suppression. Western blot serology should be preferred in this population. Finally, surgery should be considered with caution, because of its low success rate and high mortality, and conservative treatment with albendazole is well tolerated.

Published
2023
Full Text
View/download PDF

2. Genome-Wide Association Study of Acute Renal Graft Rejection

Author

Ghisdal, L., Baron, C., Lebranchu, Y., Viklický, O., Konarikova, A., Naesens, M., Kuypers, D., Dinic, M., Alamartine, E., Touchard, G., Antoine, T., Essig, M., Rerolle, J.P., Merville, P., Taupin, J.L., Le Meur, Y., Grall-Jezequel, A., Glowacki, F., Noël, C., Legendre, C., Anglicheau, D., Broeders, N., Coppieters, W., Docampo, E., Georges, M., Ajarchouh, Z., Massart, A., Racapé, J., Abramowicz, D., and Abramowicz, M.

Published
2017
Full Text
View/download PDF

3. Opportunistic infections after conversion to belatacept in kidney transplantation

Author

Isabelle Etienne, Rebecca Sberro, Cyril Garrouste, Ludivine Lebourg, Charlotte Colosio, Mathilde Lemoine, Antoine Thierry, Nicolas Bouvier, Dominique Bertrand, Philippe Gatault, Leonard Golbin, Sophie Caillard, Nathalie Chavarot, Maïté Jauréguy, Anne Grall-Jezequel, Johnny Sayegh, Dominique Guerrot, and Jean-Philippe Rerolle

Subjects
Graft Rejection, Male, medicine.medical_specialty, 030232 urology & nephrology, Renal function, Opportunistic Infections, 030230 surgery, Pneumocystis pneumonia, Belatacept, Gastroenterology, Abatacept, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Kidney transplantation, Retrospective Studies, Transplantation, business.industry, Incidence, Incidence (epidemiology), Graft Survival, Middle Aged, medicine.disease, Kidney Transplantation, Lymphoproliferative Disorders, Calcineurin, Nephrology, Cohort, Female, France, business, Immunosuppressive Agents, Glomerular Filtration Rate, medicine.drug
Abstract

Background Belatacept (bela) rescue therapy seems to be a valuable option for calcineurin inhibitor chronic toxicity in kidney transplantation. Nevertheless, the risk of infection associated with bela is not well reported. Methods We report the rate of opportunistic infections (OPI) after a switch to bela in a multicentric cohort of 280 kidney transplant patients. Results Forty-two OPI occurred in 34 patients (12.1%), on average 10.8 ± 11.3 months after the switch. With a cumulative exposure of 5128 months of bela treatment, we found an incidence of 0.008 OPI/month of exposure, and 9.8 OPI/100 person-years. The most common OPI was cytomegalovirus (CMV) disease in 18/42 OPI (42.9%) and pneumocystis pneumonia in 12/42 OPI (28.6%). Two patients presented a progressive multifocal leucoencephalopathy and two patients developed a cerebral Epstein–Barr virus-induced post-transplant lymphoproliferative disease. OPI led to death in 9/34 patients (26.5%) and graft failure in 4/34 patients (11.8%). In multivariate analysis, estimated glomerular filtration rate Conclusions The risk of OPI is significant post-conversion to bela and may require additional monitoring and prophylactic therapy, particularly regarding pneumocystis pneumonia and CMV disease. These data need to be confirmed in a larger case–control study.

Published
2020
Full Text
View/download PDF

4. Opportunistic Infections and Efficacy Following Conversion to Belatacept-Based Therapy after Kidney Transplantation: A French Multicenter Cohort

Author

Rebecca Sberro, Antoine Thierry, Johan Noble, Anne Grall-Jezequel, Paolo Malvezzi, Johnny Sayegh, Nicolas Bouvier, Sophie Caillard, Florian Terrec, Maïté Jauréguy, Cyril Garrouste, Leonard Golbin, Eric Thervet, Thomas Jouve, Lionel Rostaing, Jean-Philippe Rerolle, Nathalie Chavarot, Philippe Gatault, Charlotte Colosio, Bénédicte Janbon, Dominique Bertrand, and Isabelle Etienne

Subjects
medicine.medical_specialty, 030232 urology & nephrology, Renal function, kidney transplantation, lcsh:Medicine, 030230 surgery, Pneumocystis pneumonia, Belatacept, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Cumulative incidence, tacrolimus, Kidney transplantation, belatacept, business.industry, Incidence (epidemiology), pneumocystis pneumonia, lcsh:R, General Medicine, opportunistic infections, medicine.disease, Cohort, business, CMV infection, medicine.drug, Cohort study
Abstract

Conversion from calcineurin-inhibitors (CNIs) to belatacept can help kidney-transplant (KT) recipients avoid CNI-related nephrotoxicity. The risk of associated opportunistic infections (OPIs) is ill-defined. We conducted a multicentric cohort study across 15 French KT-centers in a real-life setting. Between 07-2010 and 07-2019, 453 KT recipients were converted from CNI- to belatacept-based therapy at 19 [0.13&ndash, 431] months post-transplantation. Most patients, i.e., 332 (79.3%), were converted after 6-months post-transplantation. Follow-up time after conversion was 20.1 +/&minus, 13 months. OPIs developed in 42(9.3%) patients after 14 +/&minus, 12 months post-conversion. Eight patients (19%) had two OPI episodes during follow-up. Incidences of CMV DNAemia and CMV disease were significantly higher in patients converted before 6-months post-KT compared to those converted later (i.e., 31.6% vs. 11.5%, p &lt, 0.001, and 11.6% vs. 2.4%, p &lt, 0.001, respectively). Cumulative incidence of OPIs was 6.5 OPIs/100 person&ndash, years. Incidence of CMV disease was 2.8/100 person&ndash, years, of pneumocystis pneumonia 1.6/100 person&ndash, years, and of aspergillosis 0.2/100 person&ndash, years. Multivariate analyses showed that estimated glomerular filtration (eGFR) &lt, 25 mL/min/1.73 m2 at conversion was independently associated with OPIs (HR = 4.7 (2.2 &minus, 10.3), p &lt, 0.001). The incidence of EBV DNAemia was 17.3 events /100 person&ndash, years. At 1-year post-conversion, mean eGFR had significantly increased from 32.0 +/&minus, 18 mL/min/1.73 m2 to 42.2 +/&minus, 18 mL/min/1.73 m2 (p &lt, 0.0001). Conversion to belatacept is an effective strategy with a low infectious risk.

Published
2020

5. Opportunistic Infections and Efficacy Following Conversion to Belatacept-Based Therapy after Kidney Transplantation: A French Multicenter Cohort

Author

Bertrand, Dominique, primary, Terrec, Florian, additional, Etienne, Isabelle, additional, Chavarot, Nathalie, additional, Sberro, Rebecca, additional, Gatault, Philippe, additional, Garrouste, Cyril, additional, Bouvier, Nicolas, additional, Grall-Jezequel, Anne, additional, Jaureguy, Maïté, additional, Caillard, Sophie, additional, Thervet, Eric, additional, Colosio, Charlotte, additional, Golbin, Leonard, additional, Rerolle, Jean-Philippe, additional, Thierry, Antoine, additional, Sayegh, Johnny, additional, Janbon, Bénédicte, additional, Malvezzi, Paolo, additional, Jouve, Thomas, additional, Rostaing, Lionel, additional, and Noble, Johan, additional

Published
2020
Full Text
View/download PDF

6. Opportunistic infections after conversion to belatacept in kidney transplantation

Author

Bertrand, Dominique, primary, Chavarot, Nathalie, additional, Gatault, Philippe, additional, Garrouste, Cyril, additional, Bouvier, Nicolas, additional, Grall-Jezequel, Anne, additional, Jaureguy, Maïté, additional, Caillard, Sophie, additional, Lemoine, Mathilde, additional, Colosio, Charlotte, additional, Golbin, Léonard, additional, Rerolle, Jean-Philippe, additional, Thierry, Antoine, additional, Sayegh, Johnny, additional, Etienne, Isabelle, additional, Lebourg, Ludivine, additional, Sberro, Rebecca, additional, and Guerrot, Dominique, additional

Published
2020
Full Text
View/download PDF

7. Genome-Wide Association Study of Acute Renal Graft Rejection

Author

Yvon Lebranchu, Christian Noel, Annick Massart, Elisa Docampo, Guy Touchard, Anne Grall-Jezequel, Daniel Abramowicz, Maarten Naesens, Marie Essig, A Konarikova, Michel Georges, Judith Racapé, T Antoine, Pierre Merville, Jean-Luc Taupin, Dany Anglicheau, Y. Le Meur, François Glowacki, Ondrej Viklický, Lidia Ghisdal, Marc Abramowicz, M. Dinic, Ch. Legendre, Christophe Baron, Wouter Coppieters, Z. Ajarchouh, Dirk Kuypers, Jean-Philippe Rerolle, Eric Alamartine, Nilufer Broeders, Department of Nephrology - Dialysis and Renal Transplantation, Hôpital Erasmes, Service de néphrologie et immunologie clinique, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours, Department of Nephrology, Intitute for clinical and Experimental Medicine, Department of microbiology and Immunology, University of Leuven K.U.Leuven, Department of Nephrology and Renal Transplantation, University Hospitals Leuven [Leuven]-Catholic University Leuven, CHU de Saint-Etienne, CHU de Saint-Etienne-CHU de Saint-Etienne, Département de Néphrologie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Lebanese University [Beirut] (LU), Hydrosciences Montpellier (HSM), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHRU - Service de néphrologie, dialyse et transplantation rénale, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), LabEX IGO Immunothérapie Grand Ouest, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Service de néphrologie adultes [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique] (IRIBHM), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Centre of Epidemiology Biostatistic and Clinical Research, Université libre de Bruxelles (ULB), Department of Nephrology Antwerp, University of Antwerp (UA), Medical Genetics Department, Brussels, Hôpital Erasme [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Nantes Université (Nantes Univ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Hôpital Bretonneau-Université de Tours-CHRU Tours, Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Lebanese University [Beirut], Hydrosciences Montpellier ( HSM ), Institut de Recherche pour le Développement ( IRD ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Lymphocyte B et Auto-immunité ( LBAI ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Impact de l'environnement chimique sur la santé humaine ( IMPECS ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ) -Université de Lille, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) ( INRS ( Vandoeuvre lès Nancy) ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Institut Necker Enfants-Malades (INEM) ( INEM - UM 111 (UMR 8253 / U1151) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Groupe Interdisciplinaire de Génoprotéomique Appliquée ( GIGA-Research ), Université de Liège-Faculté de médecine vétérinaire, Science des Procédés Céramiques et de Traitements de Surface ( SPCTS ), Université de Limoges ( UNILIM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Chimie du CNRS ( INC ) -Ecole Nationale Supérieure de Céramique Industrielle ( ENSCI ) -Institut des Procédés Appliqués aux Matériaux ( IPAM ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Insitute of Interdisciplinary Research in Molecular and Human Biology (IRIBHM), Université Libre de Bruxelles [Bruxelles] ( ULB ), University of Antwerp ( UA ), Hôpital Erasme (Bruxelles), Hôpital Bretonneau-Université de Tours-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Impact de l'environnement chimique sur la santé humaine (IMPECS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Université Libre de Bruxelles [Bruxelles] (ULB), Service de Néphrologie et d’Immunologie Clinique, Hôpital Bretonneau-CHU Tours, Pharmacologie des Immunosuppresseurs et de la Transplantation ( PIST ), Université de Limoges ( UNILIM ) -CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST FR CNRS 3503 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Néphrologie, Dialyse, Transplantations [CHU Limoges], CHU Limoges, Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Département d'Immunologie et Histocompatiblité, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Department of Nephrology, University Hospital, Lille, France., Department of Nephrology, University Hospital, Service de Néphrologie et Transplantation rénale [CHRU-lille], CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Instiitut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire ( IRIBHM ), Medical Genetics Department, Hopital Erasme, Université Libre de Bruxelles [Bruxelles] ( ULB ) -Université Libre de Bruxelles [Bruxelles] ( ULB ), Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)

Subjects
Graft Rejection, Male, 0301 basic medicine, basic (laboratory) research/science, Génétique clinique, rejection: T cell mediated (TCMR), Genome-wide association study, kidney transplantation/nephrology, Immunogenetics, immunosuppression/immune modulation, 030230 surgery, 0302 clinical medicine, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Immunology and Allergy, Medicine, Pharmacology (medical), genetics, ComputingMilieux_MISCELLANEOUS, Néphrologie - urologie, Receptor-Like Protein Tyrosine Phosphatases, Class 3, T cell mediated (TCMR) [rejection], Clinical Science, Middle Aged, Prognosis, 3. Good health, Acute Disease, Cohort, biomarker, [SDV.IMM]Life Sciences [q-bio]/Immunology, Original Article, Female, Microtubule-Associated Proteins, Adult, Genetic Markers, Locus (genetics), Genomics, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 03 medical and health sciences, microarray/gene array, genomics, Humans, Gene, Transplantation, business.industry, Tumor Suppressor Proteins, Original Articles, Transplantation d'organes, Kidney Transplantation, Sciences biomédicales, immunogenetics, 030104 developmental biology, Case-Control Studies, Immunology, Kidney Failure, Chronic, Human medicine, business, Genome-Wide Association Study
Abstract

Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed a genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated rejection occurring in the first year after renal transplantation. In a discovery cohort of 4127 European renal allograft recipients transplanted in eight European centers, we used a DNA pooling approach to compare 275 cases and 503 controls, on Illumina 2·5 M arrays. In an independent replication cohort of 2765 patients transplanted in two European countries, we identified 313 cases and 531 controls, in whom we genotyped individually the most significant SNPs from the discovery cohort. In the discovery cohort, we found 5 candidate loci tagged by a number of contiguous SNPs (>5) that was never reached in iterative in silico permutations of our experimental data. In the replication cohort, two loci remained significantly associated with acute rejection in both univariate and multivariate analysis. One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signalling. The other locus involves ciliary gene CCDC67, in line with the emerging concept of a shared building design between the immune synapse and the primary cilium. This article is protected by copyright. All rights reserved., FLWOA, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017
Full Text
View/download PDF

8. Genome-wide association study of acute renal graft rejection.

Author

Ghisdal, Lidia, Baron, Christophe, Lebranchu, Yvon, Viklicky, Ondrej, Konarikova, A, Naesens, Maarten, Kuypers, Dirk, Dinic, Miriana, Alamartine, Eric, Touchard, Guy, Antoine-Moussiaux, T., Essig, Marie, Rerolle, Jean-Philippe, Merville, Pierre, Taupin, J L, Le Meur, Yann, Grall-Jezequel, A, Glowacki, François, Noel, Christian, Legendre, Christophe, Anglicheau, D, Broeders, Emine Nilufer, Coppieters, Wouter, Docampo, E, Georges, Michel, Ajarchouh, Zineb, Massart, Annick, Racapé, Judith, Abramowicz, Daniel, Abramowicz, Marc, Ghisdal, Lidia, Baron, Christophe, Lebranchu, Yvon, Viklicky, Ondrej, Konarikova, A, Naesens, Maarten, Kuypers, Dirk, Dinic, Miriana, Alamartine, Eric, Touchard, Guy, Antoine-Moussiaux, T., Essig, Marie, Rerolle, Jean-Philippe, Merville, Pierre, Taupin, J L, Le Meur, Yann, Grall-Jezequel, A, Glowacki, François, Noel, Christian, Legendre, Christophe, Anglicheau, D, Broeders, Emine Nilufer, Coppieters, Wouter, Docampo, E, Georges, Michel, Ajarchouh, Zineb, Massart, Annick, Racapé, Judith, Abramowicz, Daniel, and Abramowicz, Marc

Abstract

Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed a genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated rejection occurring in the first year after renal transplantation. In a discovery cohort of 4127 European renal allograft recipients transplanted in eight European centers, we used a DNA pooling approach to compare 275 cases and 503 controls, on Illumina 2·5 M arrays. In an independent replication cohort of 2765 patients transplanted in two European countries, we identified 313 cases and 531 controls, in whom we genotyped individually the most significant SNPs from the discovery cohort. In the discovery cohort, we found 5 candidate loci tagged by a number of contiguous SNPs (>5) that was never reached in iterative in silico permutations of our experimental data. In the replication cohort, two loci remained significantly associated with acute rejection in both univariate and multivariate analysis. One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signalling. The other locus involves ciliary gene CCDC67, in line with the emerging concept of a shared building design between the immune synapse and the primary cilium. This article is protected by copyright. All rights reserved., FLWOA, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

9. Abnormal distribution of B-cell populations associated with impaired regulatory functions in the chronic antibody mediated rejection

Author

I. Ségalen, Alexandre Nouël, Sophie Hillion, Anne Grall-Jezequel, Yannick Le Meur, Jacques-Olivier Pers, LabEX IGO Immunothérapie Grand Ouest, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Nephrologie (CHU - BREST - Nephrologie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de Néphrologie, and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST )

Subjects
0303 health sciences, Immunology, Biology, Abnormal distribution, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Antibody mediated rejection, medicine, Immunology and Allergy, [SDV.IMM]Life Sciences [q-bio]/Immunology, B cell, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 030215 immunology
Abstract

International audience

Published
2013
Full Text
View/download PDF

10. Type of PKD1 Mutation Influences Renal Outcome in ADPKD

Author

Cornec-Le Gall, Emilie, primary, Audrézet, Marie-Pierre, additional, Chen, Jian-Min, additional, Hourmant, Maryvonne, additional, Morin, Marie-Pascale, additional, Perrichot, Régine, additional, Charasse, Christophe, additional, Whebe, Bassem, additional, Renaudineau, Eric, additional, Jousset, Philippe, additional, Guillodo, Marie-Paule, additional, Grall-Jezequel, Anne, additional, Saliou, Philippe, additional, Férec, Claude, additional, and Le Meur, Yannick, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results