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Your search keyword '"Gowrishankar, Swetha"' showing total 11 results
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11. The inositol 5-phosphatase INPP5K participates in the fine control of ER organization.

Author

Rui Dong, Benedetti, Lorena, Gowrishankar, Swetha, Yiying Cai, De Camilli, Pietro, Xiangming Wang, Ting Zhu, Huichao Deng, and Kang Shen

Subjects
*INOSITOL phosphatase, *ENDOPLASMIC reticulum, *PROTEINS, *MICROTUBULES, *CAENORHABDITIS elegans
Abstract

INPP5K (SKIP) is an inositol 5-phosphatase that localizes in part to the endoplasmic reticulum (ER). We show that recruitment of INPP5K to the ER is mediated by ARL6IP1, which shares features of ER-shaping proteins. Like ARL6IP1, INPP5K is preferentially localized in ER tubules and enriched, relative to other ER resident proteins (Sec61ß, VAPB, and Sac1), in newly formed tubules that grow along microtubule tracks. Depletion of either INPP5K or ARL6IP1 results in the increase of ER sheets. In a convergent but independent study, a screen for mutations affecting the distribution of the ER network in dendrites of the PVD neurons of Caenorhabditis elegans led to the isolation of mutants in CIL-1, which encodes the INPP5K worm orthologue. The mutant phenotype was rescued by expression of wild type, but not of catalytically inactive CIL-1. Our results reveal an unexpected role of an ER localized polyphosphoinositide phosphatase in the fine control of ER network organization. [ABSTRACT FROM AUTHOR]

Published
2018
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