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It is considered that origins of the sterility in approximately 25% couples are immune factors. Among them, most important role has autoimmune factors. Unfortunately, many issues of their appearance, influence and especially treatment are not clear and investigated. Aim of our research was to study the medicinal effect of the medication fertilogen in the treatment of the sterile couples with autoimmune genesis of the disease. 41 couples and 15 women aged from 17 to 43 with the diagnosis of the sterility of the autoimmune genesis, with the duration of the disease from 1 to 13 years were under our observation during one and a half year. From the autoimmune factors in the blood, sperm and cervical mucus of the probands were studied antisperma (ASA), antiovarial (AOA) and antizonapelucide (AZPA) antibodies. We explained absence of results after sterility treatment in these patients, as the consequence of the autoimmune problems. Decision was made to treat these patients with the medication fertilogen. Analysis of the results showed statistical proof of the decline of the titer of ASA in women (in the blood and cervical mucus) as well as in men (in the blood and sperm), and decline of AOA and AZPA in 2.4% and 0.7% of the observed patients. In the observed men, there was very positive dynamics; there was decline of the leicosists in the sperm. Along with the patterns of growth in the speed of the spermatozoid's movement were average as well as maximal (r=0.59), so there was increase in the chances of fertilization (R=0.32). Apart from that 29 (54%) from 56 women during the period of 1-6 month of the treatment became pregnant. On the basis of the received clinical data, medication fertilogen developed and offered by Mrs. L. Rurua in 2008, could be considered as an effective clinical mean which "leads out" inflammatory scrap from the sperm and "removes" auto aggression. It is possible to recommend for the introduction in the reproductive, urological and andrological medical practice.