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Co-producing scientific research with those who are affected by it is an emerging phenomenon in contemporary science. This article summarizes and reflects on both the process and outcome of a novel experiment to co-develop scientific research proposals in the field of Open Innovation in Science (OIS), wherein scholars engaged in the study of open and collaborative practices collaborated with the ���users��� of their research, i.e., scientists who apply such practices in their own research. The resulting co-developed research proposals focus on scientific collaboration, open data, and knowledge sharing and are available as an appendix to this article., CERN IdeaSquare Journal of Experimental Innovation, Vol. 5 No. 2 (2021)

Additional file 1. Case Study participantion details (1.1) and session outline (1.2).

Additional file 1: Supplementary file 1: Interview guide.

Objectives: Conversation Analysis of video-recordings will produce practice recommendations for interacting with children whose parents have a mental illness.Background: Supporting children to develop their own u2018voiceu2019 in healthcare is increasingly emphasised, however children of parents with mental illnesses may lack adult support in healthcare interactions. Enhancing practitioner-child communication is important to ensure these childrenu2019s needs are addressed. This project aims to understand the nature and possibilities of childrenu2019s participation in conversations about their concerns when their parent has a mental illness. This will inform the development of practice approaches within the Austrian u2018Village Projectu2019, How to raise a village to raise a child. Materials and Methods: This four-year project aims to enhance sensitive identification and strengthen support networks around these children. An underpinning philosophy is to hold the child at the centre of their own care, and listen to and assist them in identifying their own support networks.Results: Through close consultation with the clinical team, an approach was designed capitalising on investigatorsu2019 expertise in linguistics, child development, psychopathology, and sociology. This involves a series of sociological and linguistic micro-analyses (Conversation Analysis) across approximately 30 consultations between therapists and children in Marburg, Germany. Video-recordings are transcribed and translated into English, however German speakers are engaged in analysis to identify cultural nuances and support translations.Conclusion: Methodological approaches developed, and findings identified during this project, will inform the larger Village Project within the field of child mental health, importantly, addressing knowledge gaps in this area and driving practice change.

Purpose Aquaporins (AQP) form a family of specialized water channels known to transport water across cell membranes and reduce osmotic gradients. The isoform AQP4 is highly expressed in the astroglia of the brain and Müller cells in the retina. In the brain, AQP4 play a role in the control of cerebral edema by shunting excess fluid into blood vessels and by upregulating during conditions of hyperosmolarity. Thus, on the basis of the hyperosmolarity seen across the retina and choroid of hatchling chickens made myopic by form deprivation (FD), we predicted an upregulation of retinal AQP4 expression during induction of myopia. Methods Two-day-old hatchling chicks were monocularly form-deprived for 48, 72, or 96 h, and then after biometric assessment, the eyes of these animals and the normal controls of the same age were enucleated. Retinal tissue was prepared either for western blot analysis to show the presence of the AQP4 protein in the chick retina or for immunolocalization using polyclonal AQP4 antibodies to determine regional distribution and intensity of labeling during the induction of form deprivation myopia (FDM). Results As expected, ultrasonography demonstrated that all post hatchling eyes showed rapid elongation with occluded eyes elongating faster than fellow eyes or normal controls and becoming progressively more myopic with the duration of visual deprivation. Western blot analyses revealed an approximately 30 kDa band immunoreactive for AQP4 protein and confirmed the presence of AQP4 in chicks. Immunohistochemical staining showed the greatest positive immunoreactivity for antibodies to AQP4 in the inner retina along the vitreoretinal interface, nerve fiber layer, ganglion cell layer, and inner plexiform layer in all animals. The control eyes showed relatively constant levels of AQP4 expression until day 5 after which the level appeared to decrease. By comparison, positive AQP4 immunoreactivity in the nerve fiber layer increased significantly over the first 48 h in form-deprived eyes and in fellow eyes and then decreased over the next 48 h but not to the level of expression in the normal untreated eyes. Conclusions This is the first study to demonstrate the presence of AQP4 protein in the chick retina and to associate AQP4 expression in the inner retina with the initiation of form deprivation and the period of fastest axial elongation. This increased expression of AQP4 channels near the vitread border during the time of rapid growth suggests a role for AQP4 as a conduit for movement of retinal fluid into the vitreous in form-deprived chicks.