1,122 results on '"Giustiniani, A."'
Search Results
2. Identification of CD160-TM as a tumor target on triple negative breast cancers: possible therapeutic applications
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Scheffges, Claire, Devy, Jérôme, Giustiniani, Jérôme, Francois, Stessy, Cartier, Lucille, Merrouche, Yacine, Foussat, Arnaud, Potteaux, Stéphane, Bensussan, Armand, and Marie-Cardine, Anne
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- 2024
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3. Performance comparison of machine learning algorithms for maximum displacement prediction in soldier pile wall excavation
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Danial Sheini Dashtgoli, Mohammad Hossein Dehnad, Seyed Ahmad Mobinipour, and Michela Giustiniani
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Soldier pile wall ,Lateral displacements ,XGBoost ,Machine learning ,Artificial intelligence ,Engineering geology. Rock mechanics. Soil mechanics. Underground construction ,TA703-712 - Abstract
One of the common excavation methods in the construction of urban infrastructures as well as water and wastewater facilities is the excavation through soldier pile walls. The maximum lateral displacement of pile wall is one of the important variables in controlling the stability of the excavation and its adjacent structures. Nowadays, the application of machine learning methods is widely used in engineering sciences due to its low cost and high speed of calculation. This paper utilized three intelligent machine learning algorithms based on the excavation method through soldier pile walls, namely eXtreme gradient boosting (XGBoost), least square support vector regressor (LS-SVR), and random forest (RF), to predict maximum lateral displacement of pile walls. The results showed that the implemented XGBoost model performed excellently and could make predictions for maximum lateral displacement of pile walls with the mean absolute error of 0.1669, the highest coefficient of determination 0.9991, and the lowest root mean square error 0.3544. Although the LS-SVR, and RF models were less accurate than the XGBoost model, they provided good prediction results of maximum lateral displacement of pile walls for numerical outcomes. Furthermore, a sensitivity analysis was performed to determine the most effective parameters in the XGBoost model. This analysis showed that soil elastic modulus and excavation height had a strong influence on of maximum lateral displacement of pile wall prediction.
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- 2024
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4. Escores de Risco Poligênico: O Próximo Passo para Melhorar a Estratificação de Risco na Doença Arterial Coronariana?
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Ricardo Stein, Filipe Ferrari, and Diego García-Giustiniani
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Doença Arterial Coronariana ,Risco ,Genoma Humano ,Doenças Cardiovasculares ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Resumo Apesar dos avanços significativos no tratamento da doença arterial coronariana (DAC) e das reduções nas taxas de mortalidade anuais nas últimas décadas, a DAC continua sendo a principal causa de morte no mundo. Consequentemente, há uma necessidade contínua de esforços para abordar essa situação. Os algoritmos clínicos atuais para identificar pacientes em risco são particularmente imprecisos para indivíduos de risco moderado. Por esse motivo, foi sugerido que são necessários testes auxiliares, incluindo triagem genética preditiva. À medida que os estudos genéticos se expandem rapidamente e os dados genômicos se tornam mais acessíveis, diversos escores de risco genético têm sido propostos para identificar e avaliar a suscetibilidade de um indivíduo ao desenvolvimento de doenças, incluindo a DAC. De fato, o campo da genética tem contribuído substancialmente para a previsão de risco, particularmente nos casos em que as crianças têm genitores com DAC prematura, resultando em um risco aumentado de até 75%. Os escores de risco poligênico (PRSs, do inglês polygenic risk scores) surgiram como uma ferramenta potencialmente valiosa para compreender e estratificar o risco genético de um indivíduo. O PRS é calculado como uma soma ponderada de variantes de nucleotídeo único presentes em todo o genoma humano, identificáveis por meio de estudos de associação genômica ampla, e associadas a várias doenças cardiometabólicas. O uso dos PRSs é promissor, pois permite o desenvolvimento de estratégias personalizadas para prevenir ou diagnosticar patologias específicas de forma precoce. Ademais, seu uso é capaz de complementar os escores clínicos existentes, aumentando a precisão da previsão de risco individual. Consequentemente, a aplicação dos PRSs tem o potencial de impactar positivamente os custos e os desfechos adversos associados à DAC. A presente revisão narrativa oferece uma visão ampla do papel dos PRSs no contexto da DAC.
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- 2024
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5. Link between persistent, unexplained gamma-glutamyltransferase elevation and porto-sinusoidal vascular disorder
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Nicola Pugliese, Francesca Romana Ponziani, Federica Cerini, Luca di Tommaso, Federica Turati, Marco Maggioni, Matteo Angelo Manini, Francesco Santopaolo, Cristiana Bianco, Chiara Masetti, Maria Cristina Giustiniani, Carlo La Vecchia, Luca Valenti, Luigi Terracciano, Mauro Viganò, and Alessio Aghemo
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PSVD ,vascular liver disorder ,GGT ,non-cirrhotic portal hypertension ,nodular regenerative hyperplasia ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Porto-sinusoidal vascular disorder (PSVD) is a group of vascular disorders characterized by lesions involving portal venules and sinusoids, irrespective of the presence of portal hypertension. Liver biopsy is essential for diagnosis. In a single-center study, we demonstrated high rates of PSVD in patients with persistently elevated gamma-glutamyltransferase (GGT). This multicenter study aims to establish PSVD prevalence in a larger dataset of individuals with persistent and unexplained GGT elevation, and to identify associated risk factors. Methods: The study included all patients who underwent liver biopsy for persistent and unexplained GGT elevation in five Italian hepatology units between March 2015 and December 2021. Results: A total of 144 patients met the inclusion criteria. The majority were males (76/144, 52.8%) and mean age was 51.9 years (range 19-74). Only 12 (8.3%) had liver stiffness measurements (LSM) >10 kPa, while 7 (4.8%) had ultrasound evidence of portal hypertension. Histological findings were consistent with PSVD in 96 patients (67%). Alternative diagnoses were steatohepatitis in 13 (9%), sarcoidosis in 3 (2%) and congenital hepatic fibrosis in 3 (2%) patients. Histological findings were non-specific in 29 (20%) patients. PSVD was associated with male sex (odds ratio [OR] 2.60, 95% CI 1.13-5.99), LSM
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- 2024
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6. Identification of CD160-TM as a tumor target on triple negative breast cancers: possible therapeutic applications
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Claire Scheffges, Jérôme Devy, Jérôme Giustiniani, Stessy Francois, Lucille Cartier, Yacine Merrouche, Arnaud Foussat, Stéphane Potteaux, Armand Bensussan, and Anne Marie-Cardine
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TNBC ,CD160-TM ,Tumor antigen ,Antibody-based therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Despite major therapeutic advances, triple-negative breast cancer (TNBC) still presents a worth prognosis than hormone receptors-positive breast cancers. One major issue relies in the molecular and mutational heterogeneity of TNBC subtypes that is reinforced by the absence of reliable tumor-antigen that could serve as a specific target to further promote efficient tumor cell recognition and depletion. CD160 is a receptor mainly expressed by NK lymphocytes and presenting two isoforms, namely the GPI-anchored form (CD160-GPI) and the transmembrane isoform (CD160-TM). While CD160-GPI is constitutively expressed on resting cells and involved in the generation of NK cells' cytotoxic activity, CD160-TM is neo-synthesized upon activation and promotes the amplification of NK cells' killing ability. Methods CD160 expression was assessed by immunohistochemistry (IHC) and flow cytometry on TNBC patient biopsies or cell lines, respectively. Antibody (Ab)-mediated tumor depletion was tested in vitro by performing antibody-dependent cell cytotoxicity (ADCC) and phagocytosis (ADCP) assays, and in vivo on a TNBC mouse model. Results Preliminary data obtained by IHC on TNBC patients' tumor biopsies revealed an unconventional expression of CD160 by TNBC tumor cells. By using a specific but conformation-dependent anti-CD160-TM Ab, we established that CD160-TM, but not CD160-GPI, was expressed by TNBC tumor cells. A conformation-independent anti-CD160-TM mAb (22B12; muIgG2a isotype) was generated and selected according to pre-defined specificity and functional criterions. In vitro functional assays demonstrated that ADCC and ADCP could be induced in the presence of 22B12, resulting in TNBC cell line apoptosis. The ability of 22B12 to exert an in vivo anti-tumor activity was also demonstrated on a TNBC murine model. Conclusions Our data identify CD160-TM as a tumor marker for TNBC and provide a rational for the use of anti-CD160-TM antibodies as therapeutic tools in this tumor context.
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- 2024
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7. A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo
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Emilie Lesport, Lucie Commeau, Mélanie Genet, Etienne-Emile Baulieu, Marcel Tawk, and Julien Giustiniani
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tau ,tauopathies ,lysosomes ,autophagy ,FKBP52 ,zebrafish ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a decrease in FKBP52 protein levels is associated with Tau deposition in affected human brains. We have also shown that FKBP52 is physiologically present within the lysosomal system in healthy human neurons and that a decrease in FKBP52 expression alters perinuclear lysosomal positioning and Tau clearance during Tau-induced proteotoxic stress in vitro. In this study, we generate a zebrafish fkbp4 loss of function mutant and show that axonal retrograde trafficking of Lamp1 vesicles is altered in this mutant. Moreover, using our transgenic HuC::mCherry-EGFP-LC3 line, we demonstrate that the autophagic flux is impaired in fkbp4 mutant embryos, suggesting a role for Fkbp52 in the maturation of autophagic vesicles. Alterations in both axonal transport and autophagic flux are more evident in heterozygous rather than homozygous fkbp4 mutants. Finally, taking advantage of the previously described A152T-Tau transgenic fish, we show that the clearance of pathogenic A152T-Tau mutant proteins is slower in fkbp4+/− mutants in comparison to fkbp4+/+ larvae. Altogether, these results indicate that Fkbp52 is required for the normal trafficking and maturation of lysosomes and autophagic vacuoles along axons, and that its decrease is sufficient to hinder the clearance of pathogenic Tau in vivo.
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- 2024
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8. State of the art and future directions for measuring event-related potentials during cycling exercise: a systematic review
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Rémi Renoud-Grappin, Lionel Pazart, Julie Giustiniani, and Damien Gabriel
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Event-related potentials ,Cycling ,Attentional task ,Electroencephalography ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Intro Electroencephalography (EEG) is a technique for measuring brain activity that is widely used in neuroscience research. Event-related potentials (ERPs) in the EEG make it possible to study sensory and cognitive processes in the brain. Previous reports have shown that aerobic exercise can have an impact on components of ERPs such as amplitude and latency. However, they focused on the measurement of ERPs after exercise. Objectives The aim of this systematic review was to investigate the feasibility of measuring ERPs during cycling, and to assess the impact of cycling on ERPs during cycling. Methods We followed the PRISMA guidelines for new systematic reviews. To be eligible, studies had to include healthy adults and measure ERPs during cycling. All articles were found using Google Scholar and by searching references. Data extracted from the studies included: objectives of ERP studies, ERP paradigm, EEG system, study population data, exercise characteristics (duration, intensity, pedaling cadence), and ERP and behavioral outcomes. The Cochrane Risk of Bias 2 tool was used to assess study bias. Results Twenty studies were selected. The effect of cycling on ERPs was mainly based on a comparison of P3 wave amplitude between cycling and resting states, using an attentional task. The ERP paradigm most often used was the auditory oddball task. Exercise characteristics and study methods varied considerably. Discussion It is possible to measure ERPs during cycling under conditions that are likely to introduce more artifacts, including a 3-h athletic exercise session and cycling outdoors. Secondly, no assessment of the effect of cycling on ERPs was possible, because the methods differed too widely between studies. In addition, the theories proposed to explain the results sometimes seemed to contradict each other. Although most studies reported significant results, the direction of the effects was inconsistent. Finally, we suggest some areas for improvement for future studies on the subject.
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- 2024
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9. From real to virtual prism adaptation therapy: a systematic review on benefits and challenges of a new potential rehabilitation approach
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Laura Culicetto, Andreina Giustiniani, Viviana Lo Buono, Valentina Cazzato, Alessandra Falzone, Carmelo Mario Vicario, Angelo Quartarone, and Silvia Marino
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virtual reality ,prismatic adaptation ,virtual prism adaptation therapy ,spatial neglect ,rehabilitation Italiano (Italia) ,Psychology ,BF1-990 - Abstract
Prism adaptation (PA) is a sensorimotor technique that has been shown to alleviate neglect symptoms. Due to its demonstrated functional effectiveness, PA has recently been implemented in virtual reality environments. However, research on virtual prism adaptation (VPA) is limited and it lacks a standardized methodological approach. It is crucial to investigate whether VPA can be effective in inducing traditional effect of PA and to have potential utility in a rehabilitation context. Clarifying this aspect would allow the use of VPA in a wider range of contexts and neurological disorders, with the additional opportunity to overcome PA traditional limits. The aim of the present study is to revise current literature on VPA in both healthy individuals and patients highlighting also its advantages and limitations. Studies performed between 2013 and 2023 and fulfilling the inclusion criteria were searched on three electronic databases, by combining the terms “Virtual prism adaptation” and “Virtual prism adaptation therapy. Out of 123 articles, only 16 met the inclusion criteria. The current literature review suggests that VPA may serve as a potentially useful tool for inducing visuomotor adaptation, with most studies conducted in healthy individuals. The high variability in the methodologies observed among studies suggests that more standardized approaches are needed to gain a deeper understanding of the mechanisms underlying adaptation and aftereffects when PA is administered in a virtual environment. Future studies should also address practical applications and clinical efficacy of VPA, particularly in patients with spatial neglect.
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- 2024
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10. Link between persistent, unexplained gamma-glutamyltransferase elevation and porto-sinusoidal vascular disorder
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Pugliese, Nicola, Ponziani, Francesca Romana, Cerini, Federica, di Tommaso, Luca, Turati, Federica, Maggioni, Marco, Manini, Matteo Angelo, Santopaolo, Francesco, Bianco, Cristiana, Masetti, Chiara, Giustiniani, Maria Cristina, La Vecchia, Carlo, Valenti, Luca, Terracciano, Luigi, Viganò, Mauro, and Aghemo, Alessio
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- 2024
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11. Artificial intelligence applications for accurate geothermal temperature prediction in the lower Friulian Plain (north-eastern Italy)
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Sheini Dashtgoli, Danial, Giustiniani, Michela, Busetti, Martina, and Cherubini, Claudia
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- 2024
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12. Performance comparison of machine learning algorithms for maximum displacement prediction in soldier pile wall excavation
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Sheini Dashtgoli, Danial, Dehnad, Mohammad Hossein, Mobinipour, Seyed Ahmad, and Giustiniani, Michela
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- 2024
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13. Author Correction: Pictograms to aid laypeople in identifying the addictiveness of gambling products (PictoGRRed study)
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Luquiens, Amandine, Guillou, Morgane, Giustiniani, Julie, Barrault, Servane, Caillon, Julie, Delmas, Helena, Achab, Sophia, Bento, Bruno, Billieux, Joël, Brevers, Damien, Brody, Aymeric, Brunault, Paul, Challet-Bouju, Gaëlle, Chóliz, Mariano, Clark, Luke, Cornil, Aurélien, Costes, Jean-Michel, Devos, Gaetan, Díaz, Rosa, Estevez, Ana, Grassi, Giacomo, Hakansson, Anders, Khazaal, Yasser, King, Daniel L., Labrador, Francisco, Lopez-Gonzalez, Hibai, Newall, Philip, Perales, José C., Ribadier, Aurélien, Sescousse, Guillaume, Sharman, Stephen, Taquet, Pierre, Varescon, Isabelle, Von Hammerstein, Cora, Bonjour, Thierry, Romo, Lucia, and Grall-Bronnec, Marie
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- 2023
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14. Defining the concept of reserve in the motor domain: a systematic review
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Andreina Giustiniani and Angelo Quartarone
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motor system reserve ,cerebellar reserve ,motor rehabilitation ,motor unit reserve ,motor impairment ,compensatory processes ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
A reserve in the motor domain may underlie the capacity exhibited by some patients to maintain motor functionality in the face of a certain level of disease. This form of “motor reserve” (MR) could include cortical, cerebellar, and muscular processes. However, a systematic definition has not been provided yet. Clarifying this concept in healthy individuals and patients would be crucial for implementing prevention strategies and rehabilitation protocols. Due to its wide application in the assessment of motor system functioning, non-invasive brain stimulation (NIBS) may support such definition. Here, studies focusing on reserve in the motor domain and studies using NIBS were revised. Current literature highlights the ability of the motor system to create a reserve and a possible role for NIBS. MR could include several mechanisms occurring in the brain, cerebellum, and muscles, and NIBS may support the understanding of such mechanisms.
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- 2024
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15. Interdisciplinary results of an Italian research project on methane recovery and carbon dioxide storage in natural gas hydrate reservoirs
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Castellani, Beatrice, Giovannetti, Rita, Tinivella, Umberta, Cannone, Salvatore F., Fazioli, Roberto, Trippetta, Fabio, Ciulla, Michele, Canale, Valentino, Di Profio, Pietro, Gambelli, Alberto Maria, Nicolini, Andrea, Minelli, Giorgio, Barchi, Massimiliano, Zannotti, Marco, Rossi, Andrea, Giustiniani, Michela, Lanzini, Andrea, Santarelli, Massimo, and Rossi, Federico
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- 2024
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16. Peculiarity of autoimmune hepatitis triggered by SARS-CoV-2 infection
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Antonella Gallo, Francesca Ibba, Maria Grazia Massaro, Fiammetta Rognoni, Maria Cristina Giustiniani, Francesca Romana Ponziani, and Massimo Montalto
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acute hepatitis ,covid-19 ,autoimmunity ,Medicine - Abstract
Introduction: Recently, medical interest has been growing in SARS-CoV-2 infection and its multiorgan involvement, including the liver. Up until now, a few reports have described autoimmune hepatitis (AIH) triggered by SARS-CoV-2 infection, but no data are available about the specific liver inflammatory infiltrate and cluster of differentiation. We report a case of AIH triggered by SARS-CoV-2 infection, with a particular focus on its histological and mainly immunohistochemical features. Case description: A 60-year-old man, with a history of paucisymptomatic SARS-CoV-2 infection that occurred one month earlier, was admitted for alterations of hepatocellular necrosis and cholestasis indexes. He completed vaccination for SARS-CoV-2 a year earlier. The serologies for hepatotropic viruses were negative. The anti- smooth muscle antibodies (ASMA) and antinuclear antibodies (ANA) results were positive. Anti-liver kidney microsome (anti-LKM) antibodies and antimitochondrial (AMA) were negative. By liver biopsy, haematoxylin-eosin staining highlighted severe portal inflammation with a rich CD38+ plasma cell component, while immunohistochemical staining showed low cell CD4+ count and prevalence of CD8+ and CD3+. After biopsy, the patient started an immunosuppressant regimen, with benefit. Discussion: We can conclude that the patient developed a type 1 AIH triggered by SARS-CoV-2 infection. The presence of CD8 T-cells at immunohistochemical examination suggests different mechanisms from classic AIH. Similar cases are described after AIH triggered by SARS-CoV-2 vaccination. Conclusion: The AIH after SARS-CoV-2 infection developed by the patient showed a histological picture similar to a classic AIH for the abundant presence of plasma cells, and immunohistochemical features similar to those described after SARS-CoV-2-vaccination.
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- 2023
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17. The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma
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Gauci, Marie-Léa, Giustiniani, Jérôme, Lepelletier, Clémence, Garbar, Christian, Thonnart, Nicolas, Dumaz, Nicolas, Foussat, Arnaud, Lebbé, Céleste, Bensussan, Armand, and Marie-Cardine, Anne
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- 2022
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18. Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review
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Francesca Romana Ponziani, Cristiano Caruso, Ilaria Baglivo, Francesco Macagno, Antonio Gasbarrini, Francesco Santopaolo, Maria Cristina Giustiniani, Stefania Colantuono, and Maurizio Pompili
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Eosinophil ,autoimmune hepatitis ,severe eosinophilic asthma ,interleukin-5 ,benralizumab ,Medicine - Abstract
Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice.
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- 2023
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19. Pictograms to aid laypeople in identifying the addictiveness of gambling products (PictoGRRed study)
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Amandine Luquiens, Morgane Guillou, Julie Giustiniani, Servane Barrault, Julie Caillon, Helena Delmas, Sophia Achab, Bruno Bento, Joël Billieux, Damien Brevers, Aymeric Brody, Paul Brunault, Gaëlle Challet-Bouju, Mariano Chóliz, Luke Clark, Aurélien Cornil, Jean-Michel Costes, Gaetan Devos, Rosa Díaz, Ana Estevez, Giacomo Grassi, Anders Hakansson, Yasser Khazaal, Daniel L. King, Francisco Labrador, Hibai Lopez-Gonzalez, Philip Newall, José C. Perales, Aurélien Ribadier, Guillaume Sescousse, Stephen Sharman, Pierre Taquet, Isabelle Varescon, Cora Von Hammerstein, Thierry Bonjour, Lucia Romo, and Marie Grall-Bronnec
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Medicine ,Science - Abstract
Abstract The structural addictive characteristics of gambling products are important targets for prevention, but can be unintuitive to laypeople. In the PictoGRRed (Pictograms for Gambling Risk Reduction) study, we aimed to develop pictograms that illustrate the main addictive characteristics of gambling products and to assess their impact on identifying the addictiveness of gambling products by laypeople. We conducted a three-step study: (1) use of a Delphi consensus method among 56 experts from 13 countries to reach a consensus on the 10 structural addictive characteristics of gambling products to be illustrated by pictograms and their associated definitions, (2) development of 10 pictograms and their definitions, and (3) study in the general population to assess the impact of exposure to the pictograms and their definitions (n = 900). French-speaking experts from the panel assessed the addictiveness of gambling products (n = 25), in which the mean of expert’s ratings was considered as the true value. Participants were randomly provided with the pictograms and their definitions, or with a standard slogan, or with neither (control group). We considered the control group as representing the baseline ability of laypeople to assess the addictiveness of gambling products. Each group and the French-speaking experts rated the addictiveness of 14 gambling products. The judgment criterion was the intraclass coefficients (ICCs) between the mean ratings of each group and the experts, reflecting the level of agreement between each group and the experts. Exposure to the pictograms and their definition doubled the ability of laypeople to assess the addictiveness of gambling products compared with that of the group that read a slogan or the control group (ICC = 0.28 vs. 0.14 (Slogan) and 0.14 (Control)). Laypeople have limited awareness of the addictive characteristics of gambling products. The pictograms developed herein represent an innovative tool for universally empowering prevention and for selective prevention.
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- 2022
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20. Cytotoxic activity of peripheral blood mononuclear cells in patients with endometriosis: A cross-sectional study
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Raden Muharam, Arleni Bustami, Indra Gusti Mansur, Teuku Zulkifli Jacoeb, Jerome Giustiniani, Valerie Schiavon, and Armand Bensussan
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cd28, cd160, cytotoxic, endometriosis, pbmc. ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background: Endometriosis is believed to be associated with dysfunction of the lymphocyte population and cytotoxicity of natural killer (NK) cells, induced by the production of interleukin-2 (IL-2). Objective: This study aimed to investigate T lymphocytes and NK cell activity in the peripheral blood mononuclear cells (PBMCs) of women with endometriosis. Materials and Methods: PBMCs were obtained from the peripheral venous blood samples of 14 women with and without endometriosis (n = 7 for each group). Then, the PBMCs were co-cultured for 4 days and were treated with recombinant IL-2 for cytotoxic activity toward target cells (Daudi and K562 cells). The cytotoxicity activity was determined using the 51 chromium release assay before and after stimulation. Flow cytometry measurement was used to examine the expression of T lymphocytes and NK cells before and after being treated with IL-2. Results: The concentration of CD3+CD28+ (co-stimulatory) was significantly lower in the endometriosis group (65.62 ± 5.38) compared to in its counterpart (50.24 ± 4.22) (p = 0.04) before stimulation. However, no significant differences were observed in any other T lymphocytes and NK cells. It was also found that there was a significant increase of CD3-CD28+ after treatment with IL-2 only in the healthy control but not in women with endometriosis. Conclusion: Increased expression of CD160 and decreased CD28 play a role in inhibiting NK cell activation and T cell response in women with endometriosis.
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- 2022
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21. KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma
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Amandine Decroos, Morgane Cheminant, Julie Bruneau, Sylvain Carras, Vincent Parinet, Laura Pelletier, Laetitia Lacroix, Nadine Martin, Jérôme Giustiniani, Ludovic Lhermitte, Vahid Asnafi, Maxime Battistella, François Lemonnier, Laurence de Leval, Hélène Sicard, Cécile Bonnafous, Laurent Gauthier, Laurent Genestier, Stefano Caruso, Philippe Gaulard, Olivier Hermine, and Nicolas Ortonne
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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22. Cognitive impairment following breast cancer treatments: an umbrella review
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Oliva, Giulia, primary, Giustiniani, Andreina, additional, Danesin, Laura, additional, Burgio, Francesca, additional, Arcara, Giorgio, additional, and Conte, Pierfranco, additional
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- 2024
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23. Artificial intelligence applications for accurate geothermal temperature prediction in the lower Friulian Plain (north-eastern Italy)
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Dashtgoli, Danial Sheini, primary, Giustiniani, Michela, additional, Busetti, Martina, additional, and Cherubini, Claudia, additional
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- 2024
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24. Skinny emulsions take on granular matter
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Giustiniani, Anaïs, Weis, Simon, Poulard, Christophe, Kamm, Paul H., García-Moreno, Francisco, Schröter, Matthias, and Drenckhan, Wiebke
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Condensed Matter - Soft Condensed Matter - Abstract
Our understanding of the structural features of foams and emulsions has advanced significantly over the last 20 years. However, with a search for "super-stable" liquid dispersions, foam and emulsion science employs increasingly complex formulations which create solid-like visco-elastic layers at the bubble/drop surfaces. These lead to elastic, adhesive and frictional forces between bubbles/drops, impacting strongly how they pack and deform against each other, asking for an adaptation of the currently available structural description. The possibility to modify systematically the interfacial properties makes these dispersions ideal systems for the exploration of soft granular materials with complex interactions. We present here a first systematic analysis of the structural features of such a system using a model silicone emulsion containing millimetre-sized polyethylene glycol drops (PEG). Solid-like drop surfaces are obtained by polymeric cross-linking reactions at the PEG-silicone interface. Using a novel droplet-micromanipulator, we highlight the presence of elastic, adhesive and frictional interactions between two drops. We then provide for the first time a full tomographic analysis of the structural features of these emulsions. An in-depth analysis of the angle of repose, local volume fraction distributions, pair correlation functions and the drop deformations for different skin formulations allow us to put in evidence the striking difference with "ordinary" emulsions having fluid-like drop surfaces. While strong analogies with frictional hard-sphere systems can be drawn, these systems display a set of unique features due to the high deformability of the drops which await systematic exploration.
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- 2018
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25. Pictograms to aid laypeople in identifying the addictiveness of gambling products (PictoGRRed study)
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Luquiens, Amandine, Guillou, Morgane, Giustiniani, Julie, Barrault, Servane, Caillon, Julie, Delmas, Helena, Achab, Sophia, Bento, Bruno, Billieux, Joël, Brody, Aymeric, Brunault, Paul, Challet-Bouju, Gaëlle, Chóliz, Mariano, Clark, Luke, Cornil, Aurélien, Costes, Jean-Michel, Devos, Gaetan, Díaz, Rosa, Estevez, Ana, Grassi, Giacomo, Hakansson, Anders, Khazaal, Yasser, King, Daniel L., Labrador, Francisco, Lopez-Gonzalez, Hibai, Newall, Philip, Perales, José C., Ribadier, Aurélien, Sescousse, Guillaume, Sharman, Stephen, Taquet, Pierre, Varescon, Isabelle, Von Hammerstein, Cora, Bonjour, Thierry, Romo, Lucia, and Grall-Bronnec, Marie
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- 2022
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26. Interfacial tension of reactive, liquid interfaces and its consequences
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Giustiniani, Anaïs, Drenckhan, Wiebke, and Poulard, Christophe
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Physics - Chemical Physics ,Condensed Matter - Soft Condensed Matter - Abstract
Dispersions of immiscible liquids, such as emulsions and polymer blends, are at the core of many industrial applications which makes the understanding of their properties (morphology, stability, etc.) of great interest. A wide range of these properties depend on interfacial phenomena, whose understanding is therefore of particular importance. The behaviour of interfacial tension in emulsions and polymer blends is well-understood -both theoretically and experimentally -in the case of non-reactive stabilization processes using pre-made surfactants. However, this description of the interfacial tension behaviour in reactive systems, where the stabilizing agents are created in-situ (and which is more efficient as a stabilization route for many systems), does not yet find a consensus amongst the community. In this review, we compare the different theories which have been developed for non-reactive and for reactive systems, and we discuss their ability to capture the behaviour found experimentally. Finally, we address the consequences of the reactive stabilization process both on the global emulsions or polymer blend morphologies and at the interfacial scale.
- Published
- 2017
- Full Text
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27. Spatio-temporal EEG dynamics during decision-making in online poker players with problem gambling.
- Author
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Giustiniani, Julie, Nicolier, Magali, Maylié, Florine, Pazart, Lionel, Haffen, Emmanuel, and Gabriel, Damien
- Subjects
- *
COMPULSIVE gambling , *TOPOGRAPHIC maps , *CINGULATE cortex , *GAMBLING , *POKER players - Abstract
Gambling activity evolves along a continuum from recreational to Gambling Disorder (GD) and a particular challenge is to identify whether there are some neurophysiological particularities already present in gamblers at an early stage. Our main goal was to determine whether, in the gamblers' population, neural responses generated during uncertain decisions were different depending on problematic gambling risk defined by the Canadian Problem Gambling Index (CPGI). We tested the following hypothesis, that the Problem Gambling group would show a different brain activity related to outcomes processing than people with low risk. For this purpose, we established a relatively homogeneous population of Online Poker Players divided into two groups according to the CPGI (Low Risk and Problem Gambling). By means of high-density EEG, we compared the spatio-temporal dynamics generated during the completion of the Iowa Gambling Task. One specific topographic map was observed between 150–175 ms after a negative outcome for both groups, whereas it was displayed in the win condition only for the Problem Gambling group. We found that the Global Field Power of this map was negatively correlated with participants' adherence to a strategy. Source localization identified Anterior Cingulate Cortex and Temporal regions as generators of this map. Reward hypersensitivity EEG responses identified in the early outcome process could constitute a potential biomarker of problematic gambling. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo.
- Author
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Lesport, Emilie, Commeau, Lucie, Genet, Mélanie, Baulieu, Etienne-Emile, Tawk, Marcel, and Giustiniani, Julien
- Subjects
AUTOPHAGY ,AXONAL transport ,TAUOPATHIES ,MUTANT proteins ,TAU proteins - Abstract
The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a decrease in FKBP52 protein levels is associated with Tau deposition in affected human brains. We have also shown that FKBP52 is physiologically present within the lysosomal system in healthy human neurons and that a decrease in FKBP52 expression alters perinuclear lysosomal positioning and Tau clearance during Tau-induced proteotoxic stress in vitro. In this study, we generate a zebrafish fkbp4 loss of function mutant and show that axonal retrograde trafficking of Lamp1 vesicles is altered in this mutant. Moreover, using our transgenic HuC::mCherry-EGFP-LC3 line, we demonstrate that the autophagic flux is impaired in fkbp4 mutant embryos, suggesting a role for Fkbp52 in the maturation of autophagic vesicles. Alterations in both axonal transport and autophagic flux are more evident in heterozygous rather than homozygous fkbp4 mutants. Finally, taking advantage of the previously described A152T-Tau transgenic fish, we show that the clearance of pathogenic A152T-Tau mutant proteins is slower in fkbp4
+/- mutants in comparison to fkbp4+/+ larvae. Altogether, these results indicate that Fkbp52 is required for the normal trafficking and maturation of lysosomes and autophagic vacuoles along axons, and that its decrease is sufficient to hinder the clearance of pathogenic Tau in vivo. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
29. Aerial Drone Imaging in Alongshore Marine Ecosystems: Small-Scale Detection of a Coastal Spring System in the North-Eastern Adriatic Sea
- Author
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Gilda Savonitto, Paolo Paganini, Alessandro Pavan, Martina Busetti, Michela Giustiniani, Michela Dal Cin, Cinzia Comici, Stefano Küchler, and Riccardo Gerin
- Subjects
coastal monitoring ,unmanned aerial vehicles (UAVs) ,sea surface temperature ,multidisciplinary approach ,Science - Abstract
The eastern coastline of the Gulf of Trieste (north-eastern Adriatic Sea, Italy) is characterized by the occurrence of coastal and submarine freshwater springs of karstic origin. In one of these areas, we performed a survey with a drone with a thermal camera installed, in tandem with in situ oceanographic sampling with a CTD. Drone images revealed a small time-space scale (i.e., up to a few meters) phenomenon of freshwater plumes floating over seawater. Comparing sea surface temperature data with those acquired in situ revealed that the phenomenon was not clearly detectable by the classical oceanographic monitoring, this surface spring freshwater layer being too thin. Instead, the drone’s thermal camera detected these dynamics with great accuracy, indicating that aerial drones can be efficiently used for studying fine-scale events involving surface waters (e.g., spills/pollution). The experience gained allowed us to discuss some of the advantages and disadvantages of using drone thermal imaging for monitoring alongshore areas.
- Published
- 2023
- Full Text
- View/download PDF
30. Género y Pobreza de Tiempo en la ciudad de Rosario, Argentina
- Author
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Andreozzi, Lucía, Peinado, Guillermo, Giustiniani, Patricia, Geli, Miriam, and Ganem, Javier
- Published
- 2021
- Full Text
- View/download PDF
31. Gas origin linked to paleo BSR
- Author
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Iván de la Cruz Vargas-Cordero, Lucia Villar-Muñoz, Umberta Tinivella, Michela Giustiniani, Nathan Bangs, Joaquim P. Bento, and Eduardo Contreras-Reyes
- Subjects
Medicine ,Science - Abstract
Abstract The Central-South Chile margin is an excellent site to address the changes in the gas hydrate system since the last deglaciation associated with tectonic uplift and great earthquakes. However, the dynamic of the gas hydrate/free gas system along south central Chile is currently not well understood. From geophysical data and modeling analyses, we evaluate gas hydrate/free gas concentrations along a seismic line, derive geothermal gradients, and model past positions of the Bottom Simulating Reflector (BSR; until 13,000 years BP). The results reveal high hydrate/free gas concentrations and local geothermal gradient anomalies related to fluid migration through faults linked to seafloor mud volcanoes. The BSR-derived geothermal gradient, the base of free gas layers, BSR distribution and models of the paleo-BSR form a basis to evaluate the origin of the gas. If paleo-BSR coincides with the base of the free gas, the gas presence can be related to the gas hydrate dissociation due to climate change and geological evolution. Only if the base of free gas reflector is deeper than the paleo-BSR, a deeper gas supply can be invoked.
- Published
- 2021
- Full Text
- View/download PDF
32. Defining the concept of reserve in the motor domain: a systematic review
- Author
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Giustiniani, Andreina, primary and Quartarone, Angelo, additional
- Published
- 2024
- Full Text
- View/download PDF
33. Impact of online poker gambling on behavioural and neurophysiological responses to a virtual gambling task
- Author
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Giustiniani, Julie, primary, Nicolier, Magali, additional, Diwoux, Audrey, additional, Chabin, Thibaut, additional, Pazart, Lionel, additional, Haffen, Emmanuel, additional, and Gabriel, Damien, additional
- Published
- 2024
- Full Text
- View/download PDF
34. Author Correction: Pictograms to aid laypeople in identifying the addictiveness of gambling products (PictoGRRed study)
- Author
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Amandine Luquiens, Morgane Guillou, Julie Giustiniani, Servane Barrault, Julie Caillon, Helena Delmas, Sophia Achab, Bruno Bento, Joël Billieux, Damien Brevers, Aymeric Brody, Paul Brunault, Gaëlle Challet-Bouju, Mariano Chóliz, Luke Clark, Aurélien Cornil, Jean-Michel Costes, Gaetan Devos, Rosa Díaz, Ana Estevez, Giacomo Grassi, Anders Hakansson, Yasser Khazaal, Daniel L. King, Francisco Labrador, Hibai Lopez-Gonzalez, Philip Newall, José C. Perales, Aurélien Ribadier, Guillaume Sescousse, Stephen Sharman, Pierre Taquet, Isabelle Varescon, Cora Von Hammerstein, Thierry Bonjour, Lucia Romo, and Marie Grall-Bronnec
- Subjects
Medicine ,Science - Published
- 2023
- Full Text
- View/download PDF
35. A cold seep triggered by a hot ridge subduction
- Author
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Lucía Villar-Muñoz, Masataka Kinoshita, Joaquim P. Bento, Ivan Vargas-Cordero, Eduardo Contreras-Reyes, Umberta Tinivella, Michela Giustiniani, Natsue Abe, Ryo Anma, Yuji Orihashi, Hikaru Iwamori, Tomoaki Nishikawa, Eugenio Andres Veloso, and Satoru Haraguchi
- Subjects
Medicine ,Science - Abstract
Abstract The Chile Triple Junction, where the hot active spreading centre of the Chile Rise system subducts beneath the South American plate, offers a unique opportunity to understand the influence of the anomalous thermal regime on an otherwise cold continental margin. Integrated analysis of various geophysical and geological datasets, such as bathymetry, heat flow measured directly by thermal probes and calculated from gas hydrate distribution limits, thermal conductivities, and piston cores, have improved the knowledge about the hydrogeological system. In addition, rock dredging has evidenced the volcanism associated with ridge subduction. Here, we argue that the localized high heat flow over the toe of the accretionary prism results from fluid advection promoted by pressure-driven discharge (i.e., dewatering/discharge caused by horizontal compression of accreted sediments) as reported previously. However, by computing the new heat flow values with legacy data in the study area, we raise the assumption that these anomalous heat flow values are also promoted by the eastern flank of the currently subducting Chile Rise. Part of the rift axis is located just below the toe of the wedge, where active deformation and vigorous fluid advection are most intense, enhanced by the proximity of the young volcanic chain. Our results provide valuable information to current and future studies related to hydrothermal circulation, seismicity, volcanism, gas hydrate stability, and fluid venting in this natural laboratory.
- Published
- 2021
- Full Text
- View/download PDF
36. Generation of silicone poly-HIPES with controlled pore sizes via reactive emulsion stabilization
- Author
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Giustiniani, Anaïs, Guégan, Philippe, Marchand, Manon, Poulard, Christophe, and Drenckhan, Wiebke
- Subjects
Condensed Matter - Soft Condensed Matter - Abstract
Macrocellular silicone polymers are obtained after solidification of the continuous phase of a PDMS (polydimethylsiloxane) emulsion, which contains PEG (polyethylene glycol) drops of sub-millimetric dimensions. Coalescence of the liquid template emulsion is prohibited by a reactive blending approach. We investigate in detail the relationship between the interfacial properties and the emulsion stability, and we use micro- and millifluidic techniques to generation macro-cellular polymers with controlled structural properties over a wider range of cell-sizes (0.2-2mm) and volume fractions of the continuous phase (0.1-40%). This approach could easily be transferred to a wide range of polymeric systems.
- Published
- 2016
- Full Text
- View/download PDF
37. Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment
- Author
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Maresca, Rossella, Varca, Simone, Di Vincenzo, Federica, Ainora, Maria Elena, Mignini, Irene, Papa, Alfredo, Scaldaferri, Franco, Gasbarrini, Antonio, Giustiniani, Maria Cristina, Zocco, Maria Assunta, Laterza, Lucrezia, Papa, Alfredo (ORCID:0000-0002-4186-7298), Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Maresca, Rossella, Varca, Simone, Di Vincenzo, Federica, Ainora, Maria Elena, Mignini, Irene, Papa, Alfredo, Scaldaferri, Franco, Gasbarrini, Antonio, Giustiniani, Maria Cristina, Zocco, Maria Assunta, Laterza, Lucrezia, Papa, Alfredo (ORCID:0000-0002-4186-7298), Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Zocco, Maria Assunta (ORCID:0000-0002-0814-9542)
- Abstract
CMV infection is still a matter of concern in IBD patients, especially regarding the disease's relapse management. Why IBD patients, particularly those affected by ulcerative colitis, are more susceptible to CMV reactivation is not totally explained, although a weakened immune system could be the reason. Various techniques, ranging from serology to histology, can be employed to detect intestinal CMV infection; however, there is currently disagreement in the literature regarding the most effective diagnostic test. Furthermore, CMV involvement in steroid resistance has been broadly discussed, but whether CMV infection is a cause or consequence of the disease severity and, consequently, steroid refractoriness is still debated. Its potential contribution to the lack of response to advanced therapy and small molecules must be more valued and wholly explored. In this review, we look at the actual literature on CMV in IBD patients, and we suggest a pragmatic algorithm for clinical practice management of CMV infection.
- Published
- 2024
38. The p.(Cys150Tyr) variant in CSRP3 is associated with late-onset hypertrophic cardiomyopathy in heterozygous individuals
- Author
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Salazar-Mendiguchía, Joel, Barriales-Villa, Roberto, Lopes, Luis R., Ochoa, Juan P., Rodríguez-Vilela, Alejandro, Palomino-Doza, Julián, Larrañaga-Moreira, José M., Cicerchia, Marcos, Cárdenas-Reyes, Ivonne, García-Giustiniani, Diego, Brögger, Noël, Fernández, Germán, García, Soledad, Santiago, Lisi, Vélez, Paula, Ortiz-Genga, Martín, Elliott, Perry M., and Monserrat, Lorenzo
- Published
- 2020
- Full Text
- View/download PDF
39. From real to virtual prism adaptation therapy: a systematic review on benefits and challenges of a new potential rehabilitation approach.
- Author
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Culicetto, Laura, Giustiniani, Andreina, Buono, Viviana Lo, Cazzato, Valentina, Falzone, Alessandra, Vicario, Carmelo Mario, Quartarone, Angelo, and Marino, Silvia
- Abstract
Prism adaptation (PA) is a sensorimotor technique that has been shown to alleviate neglect symptoms. Due to its demonstrated functional effectiveness, PA has recently been implemented in virtual reality environments. However, research on virtual prism adaptation (VPA) is limited and it lacks a standardized methodological approach. It is crucial to investigate whether VPA can be effective in inducing traditional effect of PA and to have potential utility in a rehabilitation context. Clarifying this aspect would allow the use of VPA in a wider range of contexts and neurological disorders, with the additional opportunity to overcome PA traditional limits. The aim of the present study is to revise current literature on VPA in both healthy individuals and patients highlighting also its advantages and limitations. Studies performed between 2013 and 2023 and fulfilling the inclusion criteria were searched on three electronic databases, by combining the terms “Virtual prism adaptation” and “Virtual prism adaptation therapy. Out of 123 articles, only 16 met the inclusion criteria. The current literature review suggests that VPA may serve as a potentially useful tool for inducing visuomotor adaptation, with most studies conducted in healthy individuals. The high variability in the methodologies observed among studies suggests that more standardized approaches are needed to gain a deeper understanding of the mechanisms underlying adaptation and aftereffects when PA is administered in a virtual environment. Future studies should also address practical applications and clinical efficacy of VPA, particularly in patients with spatial neglect. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. State of the art and future directions for measuring event-related potentials during cycling exercise: a systematic review.
- Author
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Renoud-Grappin, Rémi, Pazart, Lionel, Giustiniani, Julie, and Gabriel, Damien
- Subjects
EVOKED potentials (Electrophysiology) ,CYCLING ,SENSORIMOTOR integration ,ELECTROENCEPHALOGRAPHY - Abstract
Intro: Electroencephalography (EEG) is a technique for measuring brain activity that is widely used in neuroscience research. Event-related potentials (ERPs) in the EEG make it possible to study sensory and cognitive processes in the brain. Previous reports have shown that aerobic exercise can have an impact on components of ERPs such as amplitude and latency. However, they focused on the measurement of ERPs after exercise. Objectives: The aim of this systematic review was to investigate the feasibility of measuring ERPs during cycling, and to assess the impact of cycling on ERPs during cycling. Methods: We followed the PRISMA guidelines for new systematic reviews. To be eligible, studies had to include healthy adults and measure ERPs during cycling. All articles were found using Google Scholar and by searching references. Data extracted from the studies included: objectives of ERP studies, ERP paradigm, EEG system, study population data, exercise characteristics (duration, intensity, pedaling cadence), and ERP and behavioral outcomes. The Cochrane Risk of Bias 2 tool was used to assess study bias. Results: Twenty studies were selected. The effect of cycling on ERPs was mainly based on a comparison of P3 wave amplitude between cycling and resting states, using an attentional task. The ERP paradigm most often used was the auditory oddball task. Exercise characteristics and study methods varied considerably. Discussion: It is possible to measure ERPs during cycling under conditions that are likely to introduce more artifacts, including a 3-h athletic exercise session and cycling outdoors. Secondly, no assessment of the effect of cycling on ERPs was possible, because the methods differed too widely between studies. In addition, the theories proposed to explain the results sometimes seemed to contradict each other. Although most studies reported significant results, the direction of the effects was inconsistent. Finally, we suggest some areas for improvement for future studies on the subject. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Performance comparison of machine learning algorithms for maximum displacement prediction in soldier pile wall excavation.
- Author
-
Dashtgoli, Danial Sheini, Dehnad, Mohammad Hossein, Mobinipour, Seyed Ahmad, and Giustiniani, Michela
- Subjects
DISPLACEMENT (Mechanics) ,MACHINE learning ,PREDICTION models ,PERFORMANCE evaluation ,PILES & pile driving ,EXCAVATION - Abstract
One of the common excavation methods in the construction of urban infrastructures as well as water and wastewater facilities is the excavation through soldier pile walls. The maximum lateral displacement of pile wall is one of the important variables in controlling the stability of the excavation and its adjacent structures. Nowadays, the application of machine learning methods is widely used in engineering sciences due to its low cost and high speed of calculation. This paper utilized three intelligent machine learning algorithms based on the excavation method through soldier pile walls, namely eXtreme gradient boosting (XGBoost), least square support vector regressor (LS-SVR), and random forest (RF), to predict maximum lateral displacement of pile walls. The results showed that the implemented XGBoost model performed excellently and could make predictions for maximum lateral displacement of pile walls with the mean absolute error of 0.1669, the highest coefficient of determination 0.9991, and the lowest root mean square error 0.3544. Although the LS-SVR, and RF models were less accurate than the XGBoost model, they provided good prediction results of maximum lateral displacement of pile walls for numerical outcomes. Furthermore, a sensitivity analysis was performed to determine the most effective parameters in the XGBoost model. This analysis showed that soil elastic modulus and excavation height had a strong influence on of maximum lateral displacement of pile wall prediction. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
42. Répression dictatoriale, justice transitionnelle et mémoire historique
- Author
-
Eve Fourmont Giustiniani
- Subjects
franquisme ,mémoire historique ,Querella argentina ,processus de réorganisation nationale ,justice transitionnelle ,amnistie ,Romanic languages ,PC1-5498 - Abstract
Au lendemain des dictatures espagnole (1939-1975) et argentine (1976-1983), l’objectif de réconciliation nationale visé par les processus transitionnels a requis l’application de lois d’amnistie, qui ont empêché la poursuite des auteurs de crimes commis contre les opposants à ces dictatures. Mais cette impunité a nourri un besoin social de justice et de mémoire, auquel le modèle de justice transitionnelle est venu apporter une réponse. L’article interroge la constitution de ce paradigme à travers le cas de l’Argentine, parvenue à juger les criminels de la répression dictatoriale, et le cas de l’Espagne qui se montre réticente à mener par la voie pénale cette confrontation avec son passé. Que disent ces résistances de l’actuelle démocratie espagnole ?
- Published
- 2020
- Full Text
- View/download PDF
43. Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment
- Author
-
Maresca, Rossella, primary, Varca, Simone, additional, Di Vincenzo, Federica, additional, Ainora, Maria Elena, additional, Mignini, Irene, additional, Papa, Alfredo, additional, Scaldaferri, Franco, additional, Gasbarrini, Antonio, additional, Giustiniani, Maria Cristina, additional, Zocco, Maria Assunta, additional, and Laterza, Lucrezia, additional
- Published
- 2023
- Full Text
- View/download PDF
44. A novel ABCB11 variant in compound heterozygosity: BRIC2 or PFIC2?
- Author
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Biolato, Marco, primary, Terranova, Rosy, additional, Viceconti, Nicholas, additional, Marrone, Giuseppe, additional, Miele, Luca, additional, Giustiniani, Maria Cristina, additional, Francalanci, Paola, additional, Gazzellone, Annalisa, additional, Bauleo, Alessia, additional, Falcone, Elena, additional, Genuardi, Maurizio, additional, and Grieco, Antonio, additional
- Published
- 2023
- Full Text
- View/download PDF
45. Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature
- Author
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Valerio Papa, Maria Cristina Giustiniani, Loris Riccardo Lopetuso, and Alfredo Papa
- Subjects
Ulcerative colitis ,Kaposi’s sarcoma ,Vedolizumab ,Human Herpesvirus-8 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, although less frequently, in patients treated with long-standing immunosuppressive therapy, such as in inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Case presentation Herein, we report the first case of KS in a human immunodeficiency virus (HIV)-negative 47-year old male with UC after treatment with the α4-β7 integrin inhibitor vedolizumab (VDZ). The patient underwent to colectomy for a medical refractory disease and the histological examination of the surgical specimen showed the typical findings of KS together with the HHV-8 positivity. The patient achieved a good health status, without any sign of disease recurrence. Conclusions In the present case, we can assume that VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with oncogenic potentialities and, in turn, the onset of KS. We also briefly reviewed all the cases of KS in HIV-negative patients with inflammatory bowel disease.
- Published
- 2020
- Full Text
- View/download PDF
46. A cold seep triggered by a hot ridge subduction
- Author
-
Villar-Muñoz, Lucía, Kinoshita, Masataka, Bento, Joaquim P., Vargas-Cordero, Ivan, Contreras-Reyes, Eduardo, Tinivella, Umberta, Giustiniani, Michela, Abe, Natsue, Anma, Ryo, Orihashi, Yuji, Iwamori, Hikaru, Nishikawa, Tomoaki, Veloso, Eugenio Andres, and Haraguchi, Satoru
- Published
- 2021
- Full Text
- View/download PDF
47. Gas origin linked to paleo BSR
- Author
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de la Cruz Vargas-Cordero, Iván, Villar-Muñoz, Lucia, Tinivella, Umberta, Giustiniani, Michela, Bangs, Nathan, Bento, Joaquim P., and Contreras-Reyes, Eduardo
- Published
- 2021
- Full Text
- View/download PDF
48. 857 Selective Treg depletion in solid tumors with ALD2510, a novel humanized CD25-specific, IL-2 sparing monoclonal antibody
- Author
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Anne Marie-Cardine, Armand Bensussan, Laurent Gorvel, Daniel Olive, Arnaud Foussat, Jemila Houacine, Aude Le Roy, Jérôme Giustiniani, Riad Abes, Anne-Sophie Chrétien, and Stéphane Fattori
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2021
- Full Text
- View/download PDF
49. Cognitive Impairment in Late-Life Depression: A Comparative Study of Healthy Older People, Late-Life Depression, and Mild Alzheimer's Disease Using Multivariate Base Rates of Low Scores
- Author
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Caroline Masse, Pierre Vandel, Géraldine Sylvestre, Nicolas Noiret, Djamila Bennabi, Frédéric Mauny, Marc Puyraveau, Yoan Barsznica, Jonathan Dartevelle, Agatha Meyer, Mickaël Binetruy, Marie Lavaux, Ilham Ryff, Julie Giustiniani, Eloi Magnin, Jean Galmiche, Emmanuel Haffen, and Gilles Chopard
- Subjects
late-life depression ,Alzheimer's disease ,older people ,base rates ,low scores ,false positive ,Psychology ,BF1-990 - Abstract
Late-Life Depression (LLD) is often associated with cognitive impairment. However, distinction between cognitive impairment due to LLD and those due to normal aging or mild Alzheimer's Disease (AD) remain difficult. The aim of this study was to present and compare the multivariate base rates of low scores in LLD, mild AD, and healthy control groups on a battery of neuropsychological tests. Participants (ages 60–89) were 352 older healthy adults, 390 patients with LLD, and 234 patients with mild AD (i.e., MMSE ≥ 20). Multivariate base rates of low scores (i.e., ≤ 5th percentile) were calculated for each participant group within different cognitive domains (verbal episodic memory, executive skills, mental processing speed, constructional praxis, and language/semantic memory). Obtaining at least one low score was relatively common in healthy older people controls (from 9.4 to 17.6%), and may thus result in a large number of false positives. By contrast, having at least two low scores was unusual (from 0.3 to 4.6%) and seems to be a more reliable criterion for identifying cognitive impairment in LLD. Having at least three low memory scores was poorly associated with LLD (5.9%) compared to mild AD (76.1%) and may provide a useful way to differentiate between these two conditions [χ(1)2 = 329.8, p < 0.001; Odds Ratio = 50.7, 95% CI = 38.2–77.5]. The multivariate base rate information about low scores in healthy older people and mild AD may help clinicians to identify cognitive impairments in LLD patients, improve the clinical decision-making, and target those who require regular cognitive and clinical follow-up.
- Published
- 2021
- Full Text
- View/download PDF
50. Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies
- Author
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Geri Meduri, Kevin Guillemeau, Corentin Daguinot, Omar Dounane, Melanie Genet, Luigi Ferrara, Beatrice Chambraud, Etienne Emile Baulieu, and Julien Giustiniani
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,General Neuroscience ,General Medicine ,Geriatrics and Gerontology - Abstract
Background: Pathological tau proteins constitute neurofibrillary tangles that accumulate in tauopathies including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and familial frontotemporal lobar degeneration (FTLD-Tau). We previously showed that the FKBP52 immunophilin interacts functionally with tau and strongly decreases in AD brain neurons in correlation with tau deposition. We also reported that FKBP52 co-localizes with autophagy-lysosomal markers and an early pathological tau isoform in AD neurons, suggesting its involvement in autophagic tau clearance. Objective: Our objective was to evaluate if differences in neuronal FKBP52 expression levels and subcellular localization might be detected in AD, PSP, familial FTLD-Tau, and in the hTau-P301 S mouse model compared to controls. Methods: Cell by cell immunohistofluorescence analyses and quantification of FKBP52 were performed on postmortem brain samples of some human tauopathies and on hTau-P301 S mice spinal cords. Results: We describe a similar FKBP52 decrease and its localization with early pathological tau forms in the neuronal autophagy-lysosomal pathway in various tauopathies and hTau-P301 S mice. We find that FKBP52 decreases early during the pathologic process as it occurs in rare neurons with tau deposits in the marginally affected frontal cortex region of AD Braak IV brains and in the spinal cord of symptomless 1-month-old hTau-P301 S mice. Conclusion: As FKBP52 plays a significant role in cellular signaling and conceivably in tau clearance, our data support the idea that the prevention of FKBP52 decrease or the restoration of its normal expression at early pathologic stages might represent a new potential therapeutic approach in tauopathies including AD, familial FTLD-Tau, and PSP.
- Published
- 2023
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