1. Adalimumab for juvenile idiopathic arthritis-associated uveitis
- Author
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Francesca Orlando, Loredana Latanza, Adriano Magli, Maria Alessio, Raimondo Forte, Pasqualina Navarro, G Russo, Adriano, Magli, Forte, Raimondo, Pasqualina, Navarro, Giustina, Russo, Francesca, Orlando, Loredana, Latanza, and Alessio, Maria
- Subjects
musculoskeletal diseases ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Visual Acuity ,Ocular hypertension ,Arthritis ,Intraocular lens ,Antibodies, Monoclonal, Humanized ,Cellular and Molecular Neuroscience ,Internal medicine ,medicine ,Adalimumab ,Juvenile ,Humans ,Prospective Studies ,Fluorescein Angiography ,skin and connective tissue diseases ,Child ,Intraocular Pressure ,business.industry ,Polyarticular Arthritis ,medicine.disease ,Uveitis, Anterior ,Sensory Systems ,Arthritis, Juvenile ,uveiti ,Ophthalmology ,juvenile ,Treatment Outcome ,Antirheumatic Agents ,Child, Preschool ,Female ,Anterior uveitis ,business ,Uveitis ,Tomography, Optical Coherence ,medicine.drug ,Follow-Up Studies - Abstract
PURPOSE: To assess the long-term outcomes and complications of patients with uveitis from juvenile idiopathic arthritis (JIA) treated with adalimumab. METHODS: Prospective interventional case series. All patients who underwent treatment with adalimumab for JIA and anterior uveitis were prospectively included in the study. The anterior chamber inflammation was evaluated according to the Standardization of Uveitis Nomenclature criteria. RESULTS: Twenty-one patients (16 females, five males, 38 eyes) were included in the study. Mean age of patients at referral was 11.1 ± 3.8 (5-17) years. Before initiation of treatment, mean duration of arthritis was 7.0 ± 5.5 (median, 6) months, mean duration of uveitis was 7.0 ± 4.4 (median, 7) months. Oligoarticular arthritis was present in 15 cases (71 %), polyarticular arthritis in six cases (28 %). After a mean follow-up of 18.2 ± 7.7 (9-41) months, resolution of anterior chamber inflammation was obtained in 29/38 eyes (76 %). The anterior uveitis flare rate during the 12 months prior to enrollment was 1.6 ± 0.4/year, and was reduced during adalimumab treatment to 0.7 ± 0.3/year (p0.05). CONCLUSION: Adalimumab showed to be effective and relatively safe for treatment of JIA-associated uveitis.
- Published
- 2012