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2. A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study

Author

Jefferson, Emily, primary, Cole, Christian, additional, Mumtaz, Shahzad, additional, Cox, Samuel, additional, Giles, Thomas Charles, additional, Adejumo, Sam, additional, Urwin, Esmond, additional, Lea, Daniel, additional, Macdonald, Calum, additional, Best, Joseph, additional, Masood, Erum, additional, Milligan, Gordon, additional, Johnston, Jenny, additional, Horban, Scott, additional, Birced, Ipek, additional, Hall, Christopher, additional, Jackson, Aaron S, additional, Collins, Clare, additional, Rising, Sam, additional, Dodsley, Charlotte, additional, Hampton, Jill, additional, Hadfield, Andrew, additional, Santos, Roberto, additional, Tarr, Simon, additional, Panagi, Vasiliki, additional, Lavagna, Joseph, additional, Jackson, Tracy, additional, Chuter, Antony, additional, Beggs, Jillian, additional, Martinez-Queipo, Magdalena, additional, Ward, Helen, additional, von Ziegenweidt, Julie, additional, Burns, Frances, additional, Martin, Joanne, additional, Sebire, Neil, additional, Morris, Carole, additional, Bradley, Declan, additional, Baxter, Rob, additional, Ahonen-Bishopp, Anni, additional, Smith, Paul, additional, Shoemark, Amelia, additional, Valdes, Ana M, additional, Ollivere, Benjamin, additional, Manisty, Charlotte, additional, Eyre, David, additional, Gallant, Stephanie, additional, Joy, George, additional, McAuley, Andrew, additional, Connell, David, additional, Northstone, Kate, additional, Jeffery, Katie, additional, Di Angelantonio, Emanuele, additional, McMahon, Amy, additional, Walker, Mat, additional, Semple, Malcolm Gracie, additional, Sims, Jessica Mai, additional, Lawrence, Emma, additional, Davies, Bethan, additional, Baillie, John Kenneth, additional, Tang, Ming, additional, Leeming, Gary, additional, Power, Linda, additional, Breeze, Thomas, additional, Murray, Duncan, additional, Orton, Chris, additional, Pierce, Iain, additional, Hall, Ian, additional, Ladhani, Shamez, additional, Gillson, Natalie, additional, Whitaker, Matthew, additional, Shallcross, Laura, additional, Seymour, David, additional, Varma, Susheel, additional, Reilly, Gerry, additional, Morris, Andrew, additional, Hopkins, Susan, additional, Sheikh, Aziz, additional, and Quinlan, Philip, additional

Published
2022
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3. Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol

Author

Wallace, Sarah, primary, Hall, Victoria, additional, Charlett, Andre, additional, Kirwan, Peter D, additional, Cole, Michele, additional, Gillson, Natalie, additional, Atti, Ana, additional, Timeyin, Jean, additional, Foulkes, Sarah, additional, Taylor-Kerr, Andrew, additional, Andrews, Nick, additional, Shrotri, Madhumita, additional, Rokadiya, Sakib, additional, Oguti, Blanche, additional, Vusirikala, Amoolya, additional, Islam, Jasmin, additional, Zambon, Maria, additional, Brooks, Tim J G, additional, Ramsay, Mary, additional, Brown, Colin S, additional, Chand, Meera, additional, and Hopkins, Susan, additional

Published
2022
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4. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Author

Angyal, Adrienn, primary, Longet, Stephanie, additional, Moore, Shona C, additional, Payne, Rebecca P, additional, Harding, Adam, additional, Tipton, Tom, additional, Rongkard, Patpong, additional, Ali, Mohammad, additional, Hering, Luisa M, additional, Meardon, Naomi, additional, Austin, James, additional, Brown, Rebecca, additional, Skelly, Donal, additional, Gillson, Natalie, additional, Dobson, Sue L, additional, Cross, Andrew, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A, additional, Tyerman, Jessica K, additional, Nicols, Alexander R, additional, Spegarova, Jarmila S, additional, Mehta, Hema, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Conlon, Christopher P, additional, Jeffery, Katie, additional, Goulder, Philip, additional, Frater, John, additional, Dold, Christina, additional, Pace, Matthew, additional, Ogbe, Ane, additional, Brown, Helen, additional, Ansari, M Azim, additional, Adland, Emily, additional, Brown, Anthony, additional, Chand, Meera, additional, Shields, Adrian, additional, Matthews, Philippa C, additional, Hopkins, Susan, additional, Hall, Victoria, additional, James, William, additional, Rowland-Jones, Sarah L, additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Richter, Alex, additional, Duncan, Christopher J A, additional, Barnes, Eleanor, additional, Carroll, Miles, additional, Turtle, Lance, additional, de Silva, Thushan I, additional, Watson, Adam, additional, Angyal, Adrienn, additional, Alhussni, Ahmed, additional, Nicols, Alexander, additional, Deeks, Alexandra, additional, Webb-Bridges, Alice, additional, Jämsén, Anni, additional, Chawla, Anu, additional, Duncan, Christopher, additional, Conlon, Christopher, additional, O'Donnell, Denise, additional, Weeks, Esme, additional, Abuelgasim, Hibatullah, additional, Xiao, Huiyuan, additional, Spegarova, Jarmila, additional, Holmes, Jennifer, additional, Haworth, Jenny, additional, Tyerman, Jessica, additional, Kilby, Jonathan, additional, Cutteridge, Joseph, additional, Lillie, Katy, additional, Romaniuk, Leigh, additional, Denly, Lucy, additional, Hering, Luisa, additional, Ansari, M. Azim, additional, Kasanyinga, Mwila, additional, Matthews, Philippa, additional, Payne, Rebecca, additional, Wilson, Robert, additional, Rowland-Jones, Sarah, additional, Thomas, Sarah, additional, Moore, Shona, additional, Gardiner, Siobhan, additional, Tucker, Stephanie, additional, Dobson, Sue, additional, Adlou, Syed, additional, de Silva, Thushan, additional, Lawrie, Allan, additional, Smith, Nikki, additional, Turton, Helena, additional, Zawia, Amira, additional, Bayley, Martin, additional, Fairman, Alex, additional, Harrington, Kate, additional, Kirk, Rosemary, additional, Marsh, Louise, additional, Watson, Lisa, additional, Wood, Steven, additional, Diffey, Benjamin, additional, Jones, Chris, additional, Lett, Lauren, additional, Platt, Gareth, additional, Subramaniam, Krishanthi, additional, Wootton, Daniel, additional, Payne, Brendan, additional, Hambleton, Sophie, additional, Kelly, Sinead, additional, Marston, Judith, additional, Poolan, Sonia, additional, Turner, Dianne, additional, Haniffa, Muzlifah, additional, Stephenson, Emily, additional, Adele, Sandra, additional, Akhter, Hossain Delowar, additional, Chinnakannan, Senthil, additional, de Lara, Catherine, additional, Donnison, Timothy, additional, Hackstein, Carl-Philipp, additional, Lee, Lian, additional, Lim, Nicholas, additional, Malone, Tom, additional, Phillips, Eloise, additional, Ramamurthy, Narayan, additional, Robinson, Nichola, additional, Sampson, Oliver, additional, Eyre, David, additional, Simmons, Beatrice, additional, Stafford, Lizzie, additional, Mentzer, Alexander, additional, Amini, Ali, additional, Arancibia-Cárcamo, Carolina, additional, Provine, Nicholas, additional, Travis, Simon, additional, Dimitriadis, Stavros, additional, Johnson, Sile, additional, Foulkes, Sarah, additional, Khawam, Jameel, additional, Wellington, Edgar, additional, Gilbert-Jaramillo, Javier, additional, Knight, Michael, additional, Dupont, Maeva, additional, Horner, Emily, additional, Thaventhiran, James, additional, and Chalk, Jeremy, additional

Published
2022
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5. Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Author

Payne, Rebecca P., primary, Longet, Stephanie, additional, Austin, James A., additional, Skelly, Donal T., additional, Dejnirattisai, Wanwisa, additional, Adele, Sandra, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Moore, Shona C., additional, Tipton, Tom, additional, Hering, Luisa M., additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Nicols, Alexander R., additional, Gillson, Natalie, additional, Dobson, Susan L., additional, Amini, Ali, additional, Supasa, Piyada, additional, Cross, Andrew, additional, Bridges-Webb, Alice, additional, Reyes, Laura Silva, additional, Linder, Aline, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A., additional, Tyerman, Jessica K., additional, Altmann, Thomas, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Phillips, Eloise, additional, Malone, Tom, additional, Hargreaves, Alexander, additional, Shields, Adrian, additional, Saei, Ayoub, additional, Foulkes, Sarah, additional, Stafford, Lizzie, additional, Johnson, Sile, additional, Wootton, Daniel G., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa C., additional, Frater, John, additional, Deeks, Alexandra S., additional, Pollard, Andrew J., additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolsapaya, Juthathip, additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria, additional, Dold, Christina, additional, Duncan, Christopher J.A., additional, Richter, Alex, additional, Carroll, Miles, additional, Screaton, Gavin, additional, de Silva, Thushan I., additional, Turtle, Lance, additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Abuelgasim, Hibatullah, additional, Adland, Emily, additional, Adlou, Syed, additional, Akther, Hossain Delowar, additional, Alhussni, Ahmed, additional, Ali, Mohammad, additional, Ansari, M. Azim, additional, Arancibia-Cárcamo, Carolina V., additional, Bayley, Martin, additional, Brown, Helen, additional, Chalk, Jeremy, additional, Chand, Meera, additional, Chawla, Anu, additional, Chinnakannan, Senthil, additional, Cutteridge, Joseph, additional, de Lara, Catherine, additional, Denly, Lucy, additional, Diffey, Ben, additional, Dimitriadis, Stavros, additional, Drake, Thomas M., additional, Donnison, Timothy, additional, Dupont, Maeva, additional, Eyre, David, additional, Fairman, Alex, additional, Gardiner, Siobhan, additional, Gilbert-Jarmillo, Javier, additional, Goulder, Philip, additional, Hackstein, Carl-Philipp, additional, Hambleton, Sophie, additional, Haniffa, Muzlifah, additional, Haworth, Jenny, additional, Holmes, Jennifer, additional, Horner, Emily, additional, Jämsén, Anni, additional, Jones, Chris, additional, Kasanyinga, Mwila, additional, Kelly, Sinead, additional, Kirk, Rosemary, additional, Knight, Michael L., additional, Lawrie, Allan, additional, Lee, Lian, additional, Lett, Lauren, additional, Lillie, Katy, additional, Lim, Nicholas, additional, Mehta, Hema, additional, Mentzer, Alexander J., additional, O’Donnell, Denise, additional, Ogbe, Ane, additional, Pace, Matthew, additional, Payne, Brendan A.I., additional, Platt, Gareth, additional, Poolan, Sonia, additional, Provine, Nicholas, additional, Ramamurthy, Narayan, additional, Robinson, Nichola, additional, Romaniuk, Leigh, additional, Rongkard, Patpong, additional, Sampson, Oliver L., additional, Simmons, Beatrice, additional, Spegarova, Jarmila S., additional, Stephenson, Emily, additional, Subramaniam, Kris, additional, Thaventhiran, James, additional, Thomas, Sarah, additional, Travis, Simon, additional, Tucker, Stephanie, additional, Turton, Helena, additional, Watson, Adam, additional, Watson, Lisa, additional, Weeks, Esme, additional, Wilson, Robert, additional, Wood, Steven, additional, Wright, Rachel, additional, Xiao, Huiyuan, additional, and Zawia, Amira A.T., additional

Published
2021
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8. A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study

Author

Emily Jefferson, Christian Cole, Shahzad Mumtaz, Samuel Cox, Thomas Charles Giles, Sam Adejumo, Esmond Urwin, Daniel Lea, Calum Macdonald, Joseph Best, Erum Masood, Gordon Milligan, Jenny Johnston, Scott Horban, Ipek Birced, Christopher Hall, Aaron S Jackson, Clare Collins, Sam Rising, Charlotte Dodsley, Jill Hampton, Andrew Hadfield, Roberto Santos, Simon Tarr, Vasiliki Panagi, Joseph Lavagna, Tracy Jackson, Antony Chuter, Jillian Beggs, Magdalena Martinez-Queipo, Helen Ward, Julie von Ziegenweidt, Frances Burns, Joanne Martin, Neil Sebire, Carole Morris, Declan Bradley, Rob Baxter, Anni Ahonen-Bishopp, Paul Smith, Amelia Shoemark, Ana M Valdes, Benjamin Ollivere, Charlotte Manisty, David Eyre, Stephanie Gallant, George Joy, Andrew McAuley, David Connell, Kate Northstone, Katie Jeffery, Emanuele Di Angelantonio, Amy McMahon, Mat Walker, Malcolm Gracie Semple, Jessica Mai Sims, Emma Lawrence, Bethan Davies, John Kenneth Baillie, Ming Tang, Gary Leeming, Linda Power, Thomas Breeze, Duncan Murray, Chris Orton, Iain Pierce, Ian Hall, Shamez Ladhani, Natalie Gillson, Matthew Whitaker, Laura Shallcross, David Seymour, Susheel Varma, Gerry Reilly, Andrew Morris, Susan Hopkins, Aziz Sheikh, Philip Quinlan, Jefferson, Emily [0000-0003-2992-7582], Cole, Christian [0000-0002-2560-2484], Mumtaz, Shahzad [0000-0003-2606-2405], Cox, Samuel [0000-0002-9841-9816], Giles, Thomas Charles [0000-0003-1356-4289], Adejumo, Sam [0000-0001-6685-3047], Urwin, Esmond [0000-0003-4626-2172], Lea, Daniel [0000-0001-8152-0398], Macdonald, Calum [0000-0001-7857-9188], Best, Joseph [0000-0001-6809-4179], Masood, Erum [0000-0001-8790-5352], Milligan, Gordon [0000-0002-1171-5234], Johnston, Jenny [0000-0002-6755-1267], Horban, Scott [0000-0001-6431-8243], Birced, Ipek [0000-0002-0048-6720], Hall, Christopher [0000-0003-1368-4619], Jackson, Aaron S [0000-0003-3217-012X], Collins, Clare [0000-0003-4679-9850], Rising, Sam [0000-0002-6934-4480], Dodsley, Charlotte [0000-0003-4825-1266], Hampton, Jill [0000-0002-3874-0819], Hadfield, Andrew [0000-0002-2976-3605], Santos, Roberto [0000-0003-1333-2605], Tarr, Simon [0000-0001-8464-1240], Panagi, Vasiliki [0000-0002-4206-4024], Lavagna, Joseph [0000-0002-3907-255X], Jackson, Tracy [0000-0002-6188-3607], Chuter, Antony [0000-0002-0646-5939], Beggs, Jillian [0000-0002-7591-3256], Martinez-Queipo, Magdalena [0000-0002-2847-334X], Ward, Helen [0000-0001-8238-5036], von Ziegenweidt, Julie [0000-0001-8776-1125], Burns, Frances [0000-0001-5885-1981], Martin, Joanne [0000-0003-2828-7253], Sebire, Neil [0000-0001-5348-9063], Morris, Carole [0000-0001-8150-8217], Bradley, Declan [0000-0003-1468-1823], Baxter, Rob [0000-0002-3693-8725], Ahonen-Bishopp, Anni [0000-0002-4215-6228], Smith, Paul [0000-0002-8598-1762], Shoemark, Amelia [0000-0001-7360-6060], Valdes, Ana M [0000-0003-1141-4471], Ollivere, Benjamin [0000-0002-1410-1756], Manisty, Charlotte [0000-0003-0245-7090], Eyre, David [0000-0001-5095-6367], Gallant, Stephanie [0000-0001-9499-3936], Joy, George [0000-0003-1467-5490], McAuley, Andrew [0000-0002-6047-2400], Connell, David [0000-0002-7008-8883], Northstone, Kate [0000-0002-0602-1983], Jeffery, Katie [0000-0002-6506-2689], Di Angelantonio, Emanuele [0000-0001-8776-6719], McMahon, Amy [0000-0003-3973-2826], Walker, Mat [0000-0002-6334-2732], Semple, Malcolm Gracie [0000-0001-9700-0418], Sims, Jessica Mai [0000-0003-1565-7315], Lawrence, Emma [0000-0001-9018-6010], Davies, Bethan [0000-0002-6585-7641], Baillie, John Kenneth [0000-0001-5258-793X], Tang, Ming [0000-0002-5498-0839], Leeming, Gary [0000-0002-5554-5302], Power, Linda [0000-0001-7503-107X], Breeze, Thomas [0000-0003-2626-527X], Murray, Duncan [0000-0003-4664-3725], Orton, Chris [0000-0002-9561-2493], Pierce, Iain [0000-0001-8546-5023], Hall, Ian [0000-0001-9933-3216], Ladhani, Shamez [0000-0002-0856-2476], Gillson, Natalie [0000-0002-6137-6728], Whitaker, Matthew [0000-0003-1363-6537], Shallcross, Laura [0000-0003-1713-2555], Seymour, David [0000-0003-4194-2056], Varma, Susheel [0000-0003-1687-2754], Reilly, Gerry [0000-0003-1427-3598], Morris, Andrew [0000-0002-1766-0473], Hopkins, Susan [0000-0001-5179-5702], Sheikh, Aziz [0000-0001-7022-3056], Quinlan, Philip [0000-0002-3012-6646], and Apollo - University of Cambridge Repository

Subjects
data privacy, clinical care, United Kingdom/epidemiology, public health, health data, COVID-19, Health Informatics, data extraction, federated network, health care, United Kingdom, health care record, meta-analysis, SDG 3 - Good Health and Well-being, infrastructure model, Humans, Pandemics, data governance, COVID-19/epidemiology
Abstract

Background COVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Kingdom’s response to the pandemic, and informed public health policies and clinical guidelines. However, these data are held by different organizations, and this fragmented landscape has presented challenges for public health agencies and researchers as they struggle to find relevant data to access and interrogate the data they need to inform the pandemic response at pace. Objective We aimed to transform UK COVID-19 diagnostic data sets to be findable, accessible, interoperable, and reusable (FAIR). Methods A federated infrastructure model (COVID - Curated and Open Analysis and Research Platform [CO-CONNECT]) was rapidly built to enable the automated and reproducible mapping of health data partners’ pseudonymized data to the Observational Medical Outcomes Partnership Common Data Model without the need for any data to leave the data controllers’ secure environments, and to support federated cohort discovery queries and meta-analysis. Results A total of 56 data sets from 19 organizations are being connected to the federated network. The data include research cohorts and COVID-19 data collected through routine health care provision linked to longitudinal health care records and demographics. The infrastructure is live, supporting aggregate-level querying of data across the United Kingdom. Conclusions CO-CONNECT was developed by a multidisciplinary team. It enables rapid COVID-19 data discovery and instantaneous meta-analysis across data sources, and it is researching streamlined data extraction for use in a Trusted Research Environment for research and public health analysis. CO-CONNECT has the potential to make UK health data more interconnected and better able to answer national-level research questions while maintaining patient confidentiality and local governance procedures.

Published
2022
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9. Acute disseminated encephalomyelitis (ADEM)-like illness in a pediatric patient following COVID-19 vaccination.

Author

Brock K, Reyes SC, Conner C, Gillson N, Weiss M, Elfituri O, and Paydar A

Abstract

Since the inception of the COVID-19 pandemic, over 60 cases of acute disseminated encephalomyelitis (ADEM) or ADEM-like clinically isolated syndromes have been linked to COVID-19 infection. However, cases linked to COVID-19 vaccination remain exceptionally rare. To the author's knowledge, eight published cases of ADEM or ADEM-like clinically isolated syndrome have been described after patients received COVID-19 vaccinations, all of which occurred in adults. This report details the first documented case of an ADEM-like illness in a pediatric patient, which developed shortly after receiving the Pfizer (Pfizer-BioNTech, Germany) COVID-19 vaccination. The patient made a near complete clinical recovery over 10 days after receiving a 5-day course of intravenous immunoglobulin therapy., (© 2023 The Authors. Published by the British Institute of Radiology.)

Published
2023
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