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The presented research paper aims to introduce a model in order to identify risks and risk factors associated with outsourcing of information technology in conjunction with health systems, measuring the probability of happening each of them and the loss of each risk. The data used in this research has been gathered from the IT experts of the healthcare sector in Tehran through the questionnaire made by the author. Then the indexes of risk exposure has been classified and ordered in seven factors, using exploratory and confirmatory factor analysis. At the end, the probability and the associated loss of each factor have been measured

Cash distributions to the shareholders, can have information content for future companies will have flexibility. Study role of Cash distributions to the shareholders and sizes of on non-governmental error forecast operating cash flows are reviewed The operational criteria used to influence the distribution of cash, the profit is divided. Company total assets and Total sales were used to measure separately. Hence the number of companies active in 71 companies during the period 90-84 Stock Bhadarthran based screening method was chosen To determine error forecast cash flow per year, the time period four years ago, the company's data, using cross-sectional regression model - multivariate combination was used Then the effect of firm size and Cash distributions to the shareholders on the error of the forecast cash flow, a comparison test we used the average of two independent communities. The results indicate the effectiveness of firm size and Cash distributions to the shareholders separately and the Precision Time on the operating cash flow error forecast and no influence of firm size and Cash distributions to the shareholders separately both the Precision Time error Forecasting free cash flow level is 95% confidence.

Background: Interstitial Pneumonitis (IP) is one of the pulmonary complications associated with mammalian Target of Rapamycin-Inhibitors (mTOR-Is). Sirolimus and everolimus belong to mTOR-Is. According to studies, IP is caused by both., Case Presentation: This is a case report in a kidney transplant recipient. We want to present a case of IP after 50 months of sirolimus consumption. Sirolimus was discontinued, and cyclosporine was started. Thirty-seven months later, everolimus was prescribed as an alternative to cyclosporine due to the recurrence of skin Squamous Cell Carcinoma (SCC). Fortunately, no respiratory manifestations were seen after more than 8 years of everolimus consumption., Conclusions: In conclusion, in cases with sirolimus-induced IP, discontinuation of sirolimus and replacement with everolimus are recommended after resolving clinical symptoms and pulmonary lesions., Competing Interests: Declarations Ethics approval and consent to participate To use the patient’s information, the study was explained to the patient before joining the study, and written informed consent was obtained. This study has been approved by Isfahan University of Medical Sciences, Research Ethics Committee (Address link: https://ethics.research.ac.ir/IR.ARI.MUI.REC.1402.168). Consent for publication Written informed consent was obtained from the participant for the publication of the case report. Competing interests The authors declare no competing interests., (© 2024. The Author(s).)

The flowers and stems of Rhubarb (Rheum ribes L.) are known to contain effective antioxidant compounds that have potential antidiarrheal properties in traditional medicine. This study was conducted to screen various genotypes of Rhubarb for their phytochemical and antioxidant activity and optimize the extraction parameters using the response surface methodology (RSM). The study found high diversity among the different genotypes (G1-G13) in terms of their flowers and stems. The total phenolic content (TPC) in the flowers of R. ribes varied significantly, showing values between 9.80 and 81.53 mg GAE g -1 DW. In the stems, TPC ranged from 2.87 to 16.33 mg GAE g -1 DW. Similarly, the total flavonoid content (TFC) in the flowers ranged from 0.33 to 1.32 mg Qu g -1 DW, while in the stems, it was between 0.05 and 0.38 mg Qu g -1 DW. The antioxidant activity, indicated as µmol Fe 2+  g -1 DW, varied from 7.42 to 59.87 in the flowers and from 0.14 to 15.99 in the stems. Hierarchical cluster analysis (HCA) identified five distinct clusters among the collected genotypes. Subsequent analysis of variance and principal components analysis (PCA) revealed that the flowers of G8 (G8F) from Tehran to Lavasan exhibited the highest total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (FRAP). Given these findings, G8F was chosen for further optimization in the study. The RSM was designed based on a Box-Behnken design (BBD) to determine the optimal extraction conditions, including extraction temperature (30-80 °C), extraction time (5-15 min), and ethanol concentration (25-75%, ethanol to water, v/v). The responses measured were total phenolic content (TPC), total flavonoid content (TFC), total anthocyanin content (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, and Ferric reducing/antioxidant power (FRAP) assays. The optimal extraction conditions for all responses or desirability indices were X 1 : 80 °C, X 2 : 15 min, and X 3 : 53.14%, which resulted in TPC (99.32 mg GAE.g -1 DW), TFC (3.00 mg Qu.g -1 DW), TAC (1.12 mg cyanidin-3-glucoside (Cy-g) g -1 DW), FRAP (110.22 µmol Fe +2 /g DW), and DPPHsc (88.20%). The R 2 values (0.91-0.99) indicated that the RSM models were acceptable., (© 2024. The Author(s).)

Background: This article introduces the first national guidelines for the management including diagnosis, treatment, and secondary prevention of acute coronary syndrome (ACS) in Iran., Materials and Methods: The members of the guideline development group (GDG) were specialists and experts in fields related to ACS and were affiliated with universities of medical sciences or scientific associations in the country. They carefully examined the evidence and clinical concerns related to ACS management and formulated 13 clinical questions that were sent to systematic review group who developed related evidence using Grade method. Finally the GDG developed the recommendations and suggestions of the guideline., Results: The first three questions in the guideline focus on providing recommendations for handling a patient who experience chest pain at home, in a health house or center, during ambulance transportation, and upon arrival at the emergency department (ED) as well as the initial diagnostic measures in the ED. Subsequently, the recommendations related to the criteria for categorizing patients into low, intermediate and high-risk groups are presented. The guideline addressed primary treatment measures for ACS patients in hospitals with and without code 247 or having primary percutaneous coronary intervention (PCI) facilities, and the appropriate timing for PCI based on the risk assessment. In addition, the most efficacious antiplatelet medications for ACS patients in the ED as well as its optimal duration of treatment are presented. The guideline details the recommendations for therapeutic interventions in patients with ACS and acute heart failure, cardiogenic shock, myocardial infarction with nonobstructive coronary arteries (MINOCA), multivessel occlusion, as well as the indication for prescribing a combined use of anticoagulants and antiplatelet during hospitalization and upon discharge. Regarding secondary prevention, while emphasizing the referral of these patients to rehabilitation centers, other interventions that include pharmaceutical and nonpharmacological ones are addressed, In addition, necessary recommendations for enhancing lifestyle and posthospital discharge pharmaceutical treatments, including their duration, are provided. There are specific recommendations and suggestions for subgroups, such as patients aged over 75 years and individuals with heart failure, diabetes, and chronic kidney disease., Conclusion: Developing guidelines for ACS diagnosis, treatment and secondary prevention according to the local context in Iran can improve the adherence of our health care providers, patients health, and policy makers plans., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Research in Medical Sciences.)

Background: Cardiovascular diseases (CVDs) and erectile dysfunction (ED) frequently co-occur, significantly affecting the quality of life of individuals., Aim: To assess the impact of cardiac rehabilitation (CR) on ED in patients with CVD through a systematic review and meta-analysis., Methods: This study analyzed randomized controlled trials and other studies comparing CR with usual care for adult males (≥18 years) with any cardiac disease. Literature searches were extensive, and the risk of bias was evaluated by the Cochrane Collaboration tool. Data from 6 studies involving 668 participants were included in the meta-analysis., Outcomes: The primary outcome was the improvement in ED, as measured with the International Index of Erectile Function., Results: A statistically significant improvement in erectile function was observed across 6 studies, with a Morris dppc2 effect size of 0.38 (95% CI, 0.17-0.59). Despite initial high heterogeneity ( I 2  = 95.7%), identification and correction for selective outcome reporting bias mitigated this issue., Clinical Translation: CR has a modest but statistically significant impact on improving ED in patients with CVD, indicating its potential positive contribution to the quality of life of this group., Strengths and Limitations: The study's strengths include a comprehensive literature search and a rigorous methodological approach. Limitations involve high heterogeneity among studies and a low level of evidence due to small sample sizes and study quality; however, the source of heterogeneity was identified and mitigated following risk-of-bias assessment., Conclusion: The results suggest that CR has a statistically significant but modest impact on improving ED in patients with CVD. Clinicians should consider the integration of CR into the clinical management of these individuals. This study underscores the potential for CR to contribute positively to the quality of life for patients with CVD by addressing associated ED (PROSPERO: CRD42022374625)., Competing Interests: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society of Sexual Medicine.)

The present study was evaluated by the incidence of vitamin D deficiency and management of hemodialysis (HD) patients with low doses of vitamin D over 6 months. This uncontrolled open-label trial was fulfilled in descriptive and then analytical phases from 2008 to 2010 recruiting chronic HD patients in our province. For this purpose, 169 patients undergoing regular HD were randomly selected and their vitamin D level was measured. Then, 54 patients with vitamin D levels less than 30 ng/mL entered the second phase. This group received 50,000 IU vitamin D3 monthly for 6 months. The mean vitamin D level in 169 patients was 21.73 ± 20.27 ng/mL. As well, 62.7% had vitamin D levels less than 30 ng/mL. Following the six-month intervention, mean vitamin D levels elevated significantly from 17.03 ± 7.4 to 42.8 ± 16.9 ng/mL (P < .0001). In this study, the incidence rate of vitamin D deficiency was 62.7%, lower than that in previous research in patients undergoing chronic HD. Vitamin D3 administration at lower doses than healthy people could significantly increase vitamin D level., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Journal of Education and Health Promotion.)

The vascular endothelial growth factor is one of the most potent tumor angiogenic factors. The best descriptors with the imperialist competitive algorithm are MATS2m, DISPe, G(O…Cl), RDF090m, Mor30v, and R2u. Masses, electro negativities, van der Waals volumes, the d COMMA2 value, the sum of the geometrical distance between O…Cl and autocorrelations are important in our study. The SMILES files have been used with Coral Sea software. We had: n =5, R ² =0.5857, Q ² =0.5170, F=4 (Calibration set), n =11, R ² =0.9842, Q ² =0.9807, F=560 (Training set), n = 5, R ² = 0.9999, Q ² = 0.9995, F = 25054 (invTrain).

Nephrolithiasis is a common disease entity around the world, with an increasing prevalence and incidence. There is no consolidated information available on the cause of kidney stones in Iranian patients. As a result, we decided to review the etiology of kidney stones in Iran. PubMed, Scopus, Web of Science, Google scholar, and Scientific Information Database (SID) were searched with the following keywords "Nephrolithiasis", "Renal stone", "Kidney stone", "Urolithiasis", "Etiology", "Metabolic abnormalities", and "Iran". There was no time period limit for selection of the papers. The inclusion criteria included any paper on evaluation of urine biochemistry regarding stone formation in Iranian adult patients (with or without children) with nephrolithiasis. We found 217 articles, of which 9 were eventually included. In conclusion, 1896 patients with nephrolithiasis from 6 provinces and 7 cities of Iran with different climates from 2000 to 2019 were evaluated collectively. The results showed that in contrast to western countries, hypercalciuria was not the most common biochemical disorder of patients with nephrolithiasis (18.2% vs. 30 to 60%). Low urine volume (49.6%) and hypocitraturia (27%) were the most frequent urine abnormalities in our country.  DOI: 10.52547/ijkd.7055.

Background: Neuropathy control and management is an objective in therapeutic exercises prescribed for patients with Type 2 diabetic peripheral neuropathy. We examined the effects of 12-week integrated exercise (IE) on glycemic control and peripheral sensation criteria in patients with diabetic neuropathy., Methods: This study was carried out in 2019-2020 in Janan diabetic society of Najaf Abad in Iran. Based on MNSI scores, we assigned 40 patients into two equal paired random groups (control vs. IE). Pre and posttests were administered before and after three months of intervention., Results: Repeated measures ANOVA showed no significant interaction effect between the FBS of the groups ( P = 0.26) but significant interaction effects were observed between the levels of 2 hrs pp G, 4 pm G, HbA1c, Diapason, Monofilament, and Thermofeel in favor of the IE group ( P < 0.05)., Conclusions: At the beginning of IE, we used massage and foam roller to release pain and improve blood circulation as well as sensation in the neuropathic areas. This may have helped the patients perform the aerobic and resistance exercises more easily. Therefore, better glycemic control and peripheral sensation were achieved. Verification of the long-term effects of this training strategy requires further study. Verification of the long-term effects of this training strategy requires further study., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 International Journal of Preventive Medicine.)

Introduction: Sirolimus (Rapamune) is an important immunosuppressive drug in kidney transplant patients. The usual maintenance dose of Sirolimus in these patients is 2 to 5 mg/d and its optimal maintenance trough level is 5 to 10 ng/mL. The required Sirolimus doses may differ markedly from patient to patient. It is because of high inter and intrapatient variability in its pharmacokinetics. There have been no studies in Iran on the correlation of Sirolimus blood level and its target dose. This study has been done to show the target dose of Sirolimus in kidney transplanted patients in Isfahan., Methods: This is a longitudinal cross-sectional study conducted from June 2018 to September 2019. The study population included all kidney transplanted patients treated with Sirolimus in a nephrology private clinic. Inclusion criteria were age (equal or more than 18 years old) and the existence of complete data in the patient's file. The participants were excluded if there were not at least two Sirolimus levels in the patient's file. Demographics and other variables were extracted from the patient's files., Results: Sirolimus was prescribed for seventy-three patients. Sixteen patients did not have the inclusion criteria. Fifty-seven renal transplanted patients were included in the study. The mean starting dose of Sirolimus in these patients was 2 ± 0.19 mg/d. The mean of the Sirolimus dose was 1.2 ± 0.44 mg/d. There was more than 20% GFR improvement in 68% of the patients after changing the Calcineurin Inhibitor to Sirolimus (P < .05)., Conclusion: In a significant number of patients changing CNI to Sirolimus accompanied by GFR improvement. Contrary to the recommended dose of Sirolimus in the references (2 to 5 mg/d) Iranian kidney transplant recipients needed lower daily doses of Sirolimus (1.2 mg/d) to achieve the desired whole blood level. Further studies are recommended to confirm it.

Background: Diazinon is one of the most common pesticides in the world playing a similar role to radiation and it could cause DNA breaks and genetic effects., Objective: In this study, radiosensitivity of a lymphoblastic cell line pretreated by Diazinon was investigated., Material and Methods: In this case-control study, the human lymphoblastic T-cell line was divided into 6 groups based on receiving radiation or/and Diazinon. After that, the DNA damage, in all of the groups, were counted by cytokinesis-block micronuclei assay using different indices., Results: The mean frequency of micronuclei, nuclear bridges and nuclear buds in cell groups exposed by both Diazinon and radiation were remarkably higher than the other groups which just received radiation or Diazinon alone. The interaction between radiation and Diazinon treatment was statistically significant for NBUDS index., Conclusion: The results indicated that the Diazinon contamination could affect the radiosensitivity index of cancerous cells while further molecular and in-vivo studies are needed to investigate genetic and toxic effects of Diazinon on DNA and its repair system., (Copyright: © Journal of Biomedical Physics and Engineering.)

Essential oils (EOs) are some of the outstanding compounds found in Thymus that can exert antifungal, phytotoxic, and insecticidal activities, which encourage their exploration and potential use for agricultural and food purposes. The essential oils (EO) obtained from Thymus kotschyanus collected in the East Azerbaijan Province (Iran) were characterized using a gas chromatography-mass spectrometry (GC-MS) analysis. Thymol was the most important compound (60.48%), although 35 other active compounds were identified in the EO. Significant amounts of carvacrol (3.08%), p -cymene (5.56%), and γ-terpinene (6.67%) were found in the EO. The T. kotschyanus EO was tested against important phytopathogenic fungi ( Botrytis cinerea, Aspergillus niger , and Penicillium expansum ). The antifungal assay showed that the use of ≥500 ppm of EO resulted in a fungicidal effect against all funguses tested. In a similar way, the use of ≥500 ppm of EO inhibited the germination of all crop weed seeds ( Amaranthus retroflexus L. and Panicum miliaceum L.) and their subsequent growth, which demonstrated its herbicidal effect. Finally, the insecticidal capacity of T. kotschyanus EO was also observed against selected insects ( Oryzaephilus surinamensis and Sitophilus oryzae ). O. surinamensis was more susceptible to the effect of EO (LC 50 = 4.78 µL/L air) than S. oryzae (LC 50 = 13.20 µL/L air). The obtained results of the present study can provide new safe resources to the development of new products for the food, agriculture, and pharmaceutical industries., Competing Interests: The authors declare no conflicts of interest.

Background: One of the treatment methods for increasing the ovarian response to ovulation induction in polycystic ovary syndrome (PCOS) is laparoscopic ovarian drilling (LOD). The optimal amount of the electrosurgical energy discharged in the ovaries to achieve maximum treatment response with minimal follicle injury is unknown. This study was performed to compare the success level of LOD by means of standard and dose-adjusted treatment methods among infertile clomiphene-resistant PCOS women., Materials and Methods: This randomized clinical trial was conducted on infertile clomiphene citrate-resistant PCOS women in the Gynaecology Department of Imam Reza Hospital between 2016 and 2017. The patients were randomly divided into two groups based on the ovarian cautery method. The two groups were examined and compared regarding the antral follicles, the serum levels of anti-Müllerian hormone (AMH), androgens, and mid-luteal progesterone one month after surgery. The regularity of cycles, ovulation, and pregnancy were examined monthly up to six months after surgery., Results: In total, 60 women received bilateral LOD (n=30 per group). The level of AMH (P=0.73), testosterone (P=0.91), and dehydroepiandrosterone sulphate (DHEAS, P=0.16) did not differ at study entrance and one month after ovarian cautery [P=0.94 (AMH), P=0.46 (testosterone), and P=0.12 (DHEAS)] and for postoperative mid-luteal progesterone (P=0.31). Intragroup comparisons showed a statistically significant difference in the decrease in the number of antral follicles and testosterone in the standard group (P=0.02) and AMH level in the cautionary dose-adjusted group (P=0.04). We observed no difference in cycle regularity (P=0.22), ovulation (P=0.11), and pregnancy (P=0.40) between the two groups after six months., Conclusion: The results indicated that there was no difference between the two methods of ovarian cautery with regards to establishing cycle regularity and ovulation. The standard treatment was effective in decreasing the numbers of antral follicles and testosterone levels, whereas the dose-adjusted method significantly affected the decrease in AMH levels (Registration Number: IRCT20171210037820N1)., Competing Interests: The authors declare no conflicts of interest., (Copyright© by Royan Institute. All rights reserved.)

Introduction: Parkinson's disease (PD) is a chronic, progressive disorder that mainly affects the central nervous system and, consequently, the patient's functional status. This study aimed to compare the effect of 8-week rebound therapy-based exercise program and weight-supported exercises on the range of motion, proprioception, and the quality of life in patients with PD., Methods: Twenty patients were randomly divided into two equal groups of weight-bearing exercises and rebound exercise with no significant differences in age, weight, and height. The variables of the range of motion, proprioception, and the quality of life were assessed in pre- and posttest. Data were analyzed using repeated measure ANOVA and t-test at a significant level of P < 0.05., Results: All of the variables in the two groups were significantly improved after 8 weeks of exercise, whereas the improvement rate in the rebound therapy group was more than the weight-bearing exercises group in range of motion (134.60 ± 13.22 vs. 118.38 ± 12.48), proprioception (7.60 ± 3.22 vs. 10.38 ± 2.48), and the quality of life (147.60 ± 13.22 vs. 118.38 ± 12.48) of the patients ( P < 0.001 for all variables)., Conclusions: Given that both rebound and weight-supported exercises are effective on improving the range of motion, proprioception, and the quality of life of people with PD, it is recommended that the benefits of these exercises to be used in physical rehabilitation programs. However, rebound therapy exercises have had a greater effect on people with PD, and it seems better to use these exercises more than others., Competing Interests: There are no conflicts of interest.

Background: Hyperkyphosis is often accompanied by forward head and shoulder postures. Together, these three disorders are called "Upper Cross Syndrome (UCS)". We aimed to perform a photogrammetric analysis of UCS among teachers and to determine the effects of National Academy of Sports Medicine (NASM) exercises with ergonomic training interventions on the syndrome., Study Design: A semi-experimental study., Methods: Photogrammetric analysis was performed using the UCS software among teachers in order to determine the angles of forward head, rounded shoulders, and hyperkyphosis. Twenty-three teachers were selected purposefully and enrolled in Fasa City in 2018. They were randomly divided into experimental (n=12) and control (n=11) groups. Experimental group attended 12 wk of NASM exercises with ergonomic intervention but the control group did not participate in any regular exercise. The data were analyzed using paired t-test and differential independent t-test (P<0.05)., Results: The results indicated a significant decrease in forward head (P=0.001), shoulder angles (P=0.000) and hyperkyphosis (P=0.003). The applied intervention had a 90% positive effect in reducing the forward head angle, an 88% positive effect in reducing the rounded shoulder angle and a 90% positive effect in reducing the kyphosis angle. However, the results for the control group did not show a significant difference for forward head, rounded shoulders, and hyperkyphosis angles., Conclusion: The UCS software application can be used as an accurate instrument for measuring the extent of the UCS. Moreover, using NASM exercises can lead to a reduction in the UCS among teachers.

Chemical composition, antifungal and antioxidant properties of essential oil extracted from Cuminum cyminum from Iran was studied. GC-MS analysis revealed the presence of 18 components, with 3-caren-10-al and cuminal as the principal constituents. Hierarchical cluster analysis and antioxidant capacities showed that this essential oil made a single group at 64 unit distinct from other reported essential oils extracted from cumin in the literature and was with high antioxidant activity [150 µL exhibiting strong reducing power; 2200 (FRAP) μmol/L Fe +2 during 15 min and ~ 89 DPPH % at 60 min]. The antifungal effects of the essential oil against three postharvest fungal pathogens, Botrytis cinerea , Aspergillus niger and Penicillim expansum revealed that at concentrations of ≥ 750 µL/L, the mycelial growth of the tested fungi were completely inhibited. Overall, the essential oil derived from this new cumin chemovar could be a promising candidate for its utilization as a natural preservative.

Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration, remyelination, and regulating the development of the peripheral and central nervous systems (PNS and CNS, respectively) by intracellular signaling through specific receptors. It has been suggested that the pathogenesis of human neurodegenerative disorders may be due to an alteration in the neurotrophic factors and their receptors. The use of neurotrophic factors as therapeutic agents is a novel strategy for restoring and maintaining neuronal function during neurodegenerative disorders such as multiple sclerosis. Innate and adaptive immune responses contribute to pathology of neurodegenerative disorders. Furthermore, autoimmune and mesenchymal stem cells, by the release of neurotrophic factors, have the ability to protect neuronal population and can efficiently suppress the formation of new lesions. So, these cells may be an alternative source for delivering neurotrophic factors into the CNS.

Background: It can be concluded from the existing theories that parental education status, by affecting socioeconomical status of families, can impact the incidence of violent behaviors in teenagers. Therefore, this study was conducted aiming at investigating the relationship between parental education and teenagers' knowledge of violent behaviors and their incidences., Methods: For this cross-sectional, descriptive-correlational study, a sample of 5500 teenager students from Isfahan province were selected by random cluster sampling and responded to a 61-item questionnaire. The data collected from by questionnaire was analyzed by Spearman's statistical correlation and multiple regression methods., Results: Most of the students under study (89.1%) were living in cities and the rest were rural dwellers. In terms of gender, female to male ratio was approximately equal (49.8% vs. 50.2%). The statistical results showed that there is a significant positive relationship between practice and knowledge (R = 0.092 and P = 0.00), but there is no significant relationship between parental education and practice and there is a significant relationship between parental education and knowledge (Mothers' education P = 0.00 and R = 0.121 and fathers' education P = 0.00 and R = 0.109). Moreover, there was a positive significant relationship between teenagers' knowledge of violence consequences (P = 0.005 and B = 0.048) violent behavior causes (P = 0.00 B = 0.085) and methods of preventing violent behaviors (P = 0.00 and B = 0.085) with teenagers' practice., Conclusions: Based on the results of the present study that indicates teenagers are less aware of the consequences of violent behavior compared to other subscales of knowledge, it is better that teenagers' education about the violent behaviors are more about the consequences of violent behavior rather than its definitions. Moreover, parental education is related to teenagers' knowledge of the violent behavior so it is better that in various grades more comprehensive and suitable information regarding violent behaviors be presented.

Background: The present study aimed to investigate the effect of stress management training through cognitive-behavioral techniques on stress, social adaptability and depression in women with depression disorders., Materials and Methods: In this study, 40 patients diagnosed with depression who had referred to psychiatry and consultation clinics of Isfahan were randomly selected and assigned to intervention and control groups (20 patients in each group). The intervention group received eight 90-min sessions of stress training through cognitive-behavioral techniques. Data collection tools included Cooper's stress questionnaire, Bell's social adaptability questionnaire and Hamilton's depression scale questionnaire. The participants completed the questionnaires before the intervention and 1 month after the same. Data analysis was performed using covariance analysis., Results: Based on the results, considering variables of stress, social adaptability and depression, the equal variance hypothesis was confirmed. The relationship between pre- and post-test scores on stress, social adaptability and depression was statistically significant (P < 0.001). The modified mean difference was F = 12.45, P < 0.001 on stress; F = 6.88, P < 0.01 on social adaptability; and F = 5.36, P < 0.02 on depression, all of which were significant., Conclusion: Stress management training through cognitive behavioral techniques can play a main role in depression reduction and development of social adaptability through modifying inappropriate social information-processing patterns.

Background & Objectives: Enhanced muscle strength is seen when resistance exercise is combined with the consumption of nutritional supplements. Although there is a limited number of studies available about the efficacy of gamma oryzanol supplementation with resistance exercise in humans, but its usage as a nutritional supplement for strength is common in athletes. The aim of this study was to determine the effects of gamma oryzanol supplementation during 9-week resistance training on muscular strength and anthropometric measurements of young healthy males., Methods: In this double-blind clinical trial, changes of anthropometric measurements and muscular strength were studied after chronic resistance exercise and gamma oryzanol supplementation in 30 healthy volunteers (16 in supplement and 14 in placebo). Each day, gamma oryzanol supplement (600 mg) and placebo (the same amount of lactose) were consumed after training. The participants exercised with 80 per cent 1-Repetition Maximum (1-RM), for one hour and four days/week. Anthropometric measurements and subjects' 1-RM for muscular strength were determined at the commencement and end of the 9-week study., Results: There was no significant difference between the baseline characteristics and target variables at baseline between the two groups. After gamma oryzanol supplementation, there was no significant difference in the means of anthropometric and skin fold measurements between the supplement and placebo groups. However, there were significant differences between the supplement and placebo groups for 1-RM of bench press and leg curl, which showed that gamma oryzanol improved muscle strength following resistance training., Interpretation & Conclusions: Our findings indicated that 600 mg/day gamma oryzanol supplementation during the 9-week resistance training did not change anthropometric and body measurements, but it increased muscular strength in young healthy males. Further, studies need to be done in trained athletes, women, and in patients who suffer from muscular fatigue.

Background: University entrance is accompanied by major changes in social relationship, rules, and expectations that lead to psychological disorders in susceptible students. The goal of this research is to study the anxiety rate in Iranian medical residents in 2010-2011., Methods: This study is a cross-sectional, descriptive study. It contains 370 medical residents from the 1(st) year to the 4(th) year of medical universities in Isfahan, Gilan, Zahedan, Sanandaj, and Kashan. The stratified sampling method proportionate to volume of participants is used in this study. The information is collected based on researchers' questioners and Zung self-rating anxiety scale and analyzed with the use of spss software version 16, addition to descriptive and analytic tests (Pearson, one-way analysis of variance, t-test). Meaningful level is regarded as P ≤ 0.05., Results: The study showed that more than 92% of residents participated in the study did not demonstrate anxiety. Among 370 subjects 5.5% presented with mild symptoms of anxiety and no one had symptom of severe anxiety. A meaningful statistical relationship was observed between anxiety and sex, major of study and the city of study (P < 0.05). The results showed a positive meaningful relationship between the number of visits and the score of anxiety. On average the number of night floats were two in 1 week and the number of patient visit was 19 in the past 24 h. A meaningful statistical relationship between anxiety score and number of patient visits was observed., Conclusions: The anxiety rate in medical students in this study compared to the findings of previous studies reveled very low anxiety in medical residents. The low rate of anxiety could be attributed to the sense of job security and the hope for a better future among residents. The high percentage of anxiolytics abuse and absence of anxiety producing factors among residents in addition to inaccurate response to the questionnaire may all contribute to the low rate of anxiety in this study.

Background: Obesity is a threat to the health of modern urban citizens, especially women. Aerobic is an effect of exercise which rapidly is developing among urban women. This study was designed to examine the effects of light and moderate aerobic intensity on body composition and serum lipid profile in obese/overweight women living in Isfahan., Methods: Forty-five middle-aged obese/overweight volunteer women (25-40 years, and body mass index (BMI) ≥25 to 30 kg/m(2)) were randomly assigned into three groups: 1. Light aerobics [45-50% heart rate reserve maximum (HRRmax)], 2. Moderate aerobics (70-75% HRRmax), 3. No exercise training (control). Training program lasted for 10 weeks and included three sessions of 60 minutes aerobics per week. The intensity of aerobics was controlled by monitoring heart rate. Body composition was measured using skin fold thickness method. Serum lipid was measured., Results: Both light and moderate aerobics significantly improved weight (P < 0.000), fat percent (P < 0.045), BMI (P < 0.000), fat weight (P < 0/031), lean body weight (P < 0.02), waist-to-hip ratio (WHR) (P < 0.000), High-density lipoprotein (HDL) (P < 0.000)., Conclusions: Our findings showed that both light and moderate aerobics improved body composition and serum lipid profile in obese/overweight women. Our findings support the application of aerobics for obese/overweight women. Initially, they can start with light programs and proceed to more intense programs.

Aims: Resistance form of full metal-ceramic crown is an important feature that determines longevity of these restorations. This study evaluated the resistance form of full metal-ceramic prepared with four different design features., Materials and Methods: An acrylic tooth was prepared with 20° total occlusal convergence (TOC) angle, 2.5 mm of occlusocervical dimension and a shoulder finishing line. This design lacked resistance form. The crown preparation was subsequently modified by preparing Mesial Occlusal Distal isthmus, placing occlusal inclined plane, and reducing TOC. Four metal dies from these designs were constructed by lathe machine and then 10 metal copings were fabricated for each preparation. Metal coping were cemented on metal dies with temp-bond cement. Force was applied at 45° from lingual to buccal direction with universal testing machine., Statistical Analysis Used: The data were evaluated by Kruskal-Wallis and non-parametric Mann-Whitney test., Results: All features increased resistance form when compare to control group. However, reduce TOC group showed greatest value of resistance., Conclusion: Within the limitation of this study, reducing the tapering of occlusocervival dimension is the most effective way in increasing resistance form, although, other features were also effective.

Background: Electroconvulsive therapy (ECT) is one of the most efficacious treatment for major depressive disorder (MDD), it is also used as a rapid and efficacious treatment for other psychiatric disorders, especially treatment resistant ones. The cognitive impairment is one of the most important side effects of ECT. This study examined the Memoral herbal efficacy in prevention of ECT-induced memory impairment., Methods: In a randomized clinical trial, 70 patients with mood disorders who were candidates for ECT enrolled in either Memoral or Control group, and received either Memoral or placebo. The memory was assessed by Addenbrook Cognitive Examination (ACE), and the findings were analyzed by ANOVA under SPSS18., Results: The Memoral group patients showed significantly higher total ACE scores than placebo group (P < 0.001). The scores of attention and orientation, verbal fluency and memory subscales not only never decreased during the study in Memoral group, but also increased. There was no significant difference between these scores of Memoral and placebo groups for the subscales of language and visuospacial ability., Conclusion: The Memoral herbal is an efficacious and safe choice in prevention of ECT- induced cognitive impairment.

The antiviral drugs that inhibit human immunodeficiency virus (HIV) entry to the target cells are already in different phases of clinical trials. They prevent viral entry and have a highly specific mechanism of action with a low toxicity profile. Few QSAR studies have been performed on this group of inhibitors. This study was performed to develop a quantitative structure-activity relationship (QSAR) model of the biological activity of indole glyoxamide derivatives as inhibitors of the interaction between HIV glycoprotein gp120 and host cell CD4 receptors. Forty different indole glyoxamide derivatives were selected as a sample set and geometrically optimized using Gaussian 98W. Different combinations of multiple linear regression (MLR), genetic algorithms (GA) and artificial neural networks (ANN) were then utilized to construct the QSAR models. These models were also utilized to select the most efficient subsets of descriptors in a cross-validation procedure for non-linear log (1/EC50) prediction. The results that were obtained using GA-ANN were compared with MLR-MLR and MLR-ANN models. A high predictive ability was observed for the MLR, MLR-ANN and GA-ANN models, with root mean sum square errors (RMSE) of 0.99, 0.91 and 0.67, respectively (N = 40). In summary, machine learning methods were highly effective in designing QSAR models when compared to statistical method.

Background: Gastric and colorectal cancers are the second and the fourth most common cancers in Iran, respectively. The presence of Murine Double Minute 2 (MDM2) has been identified in many cancers and its relationship with prognosis is under investigation. This study aimed to assess the status of MDM2 and its relationship with prognostic factors in gastric and colorectal carcinoma., Materials and Methods: This study was performed on 99 paraffin blocks of gastric and colorectal cancers, during the years 2001 to 2007 from Mostafa Khomeini Hospital, Tehran, Iran. Tissue sections were prepared, stained with Hematoxylin and Eosin and immunohistochemistry to evaluate for MDM2 expression. The type of tumor, lymph node involvement and tumor grade was determined., Results: Of the 99 cases, 34.3% and 65.7% cases were diagnosed with gastric and colorectal adenocarcinoma, respectively. The average tumor size was 5.5 cm. MDM2 expression level was 82.4% and 90.8% in gastric and colorectal adenocarcinoma, respectively. No statistical difference was found between MDM2 expression and various prognostic factors; however, significant correlation was observed between gastric (P = 0.03) and colorectal (P = 0.03) tumor size and the percentage of MDM2 immunoreactivity., Conclusion: Considering the role of MDM2 in cell growth and its positive correlation with tumor size (an established prognostic factor), it can be indirectly concluded that MDM2 is also important in prognosis. However, additional investigation is needed.

Objectives: Malva sylvestris L. (Malvaceae), an annual plant, has been already commonly used as a medicinal plant in Iran. In the present work, we evaluate some bioactivities of the plant extracts., Materials and Methods: The aired-dried plant flowers and leaves were extracted by soxhlet apparatus with n-hexane, dichloromethane and methanol. The antimicrobial, cytotoxic, and phytotoxic of the plant extracts were evaluated using disk diffusion method, MTT, and Lettuce assays, respectively., Results: Both flowers and leaves of M. sylvestris methanol extracts exhibited strong antibacterial effects against Erwinia carotovora, a plant pathogen, with MIC value of 128 and 256 µg/ml, respectively. The flowers extract also showed high antibacterial effects against some human pathogen bacteria strains such as Staphylococcus aureus, Streptococcus agalactiae, Entrococcus faecalis, with MIC value of 192, 200 and 256 µg/ml, respectively. The plant methanol extracts had relatively high cytotoxic activity against MacCoy cell line., Conclusion: We concluded that Malva sylvestris can be candidated as an antiseptic, a chemopreventive or a chemotherapeutic agent.

Objective: To evaluate maternal and perinatal outcome in nulliparious women complicated with pregnancy hypertension., Methods: This descriptive-analytic and case-control study was performed on 100 hypertensive and 100 normotensive nulliparious women who were referred to Imam Reza hospital in 2008. They were compared for maternal and perinatal outcomes. The data was analyzed by SPSS software. P < 0.05 was considered statistically significant., Results: In this study, there were no significant differences in maternal age, menstruation condition, delivery mode, placental detachment rate between the studied groups. Gestational age was significantly lower in the case group, especially in severe preeclampsia subgroup (P < 0.001). Serum creatinine level more than 1.2 mg/dl was significantly higher in mild and severe preeclampsia groups (P = 0.018). Significant differences were found in neonatal APGAR, need of rescusitation, NICU admission, birth weight and length, LBW and intrauterine growth retardation between the studied groups., Conclusion: The results of this study revealed that maternal and foetal-neonatal complications mostly appear in pregnancy complicated with induced hypertension especially in severe preeclampsia.

Introduction: PERF15 is a testicular germ-cell specific fatty-acid binding protein (FABP) isolated from mammals, originally from rats. It encodes one of the most abundant proteins of rat spermatozoa localized in the perinuclear theca. Northern blot analysis has demonstrated that rat PERF15 mRNA is exclusively transcribed during meiosis and post-meiosis. In this study, we cloned and sequenced human PERF15 gene., Materials and Methods: According to the open reading frame of automated computational analysis of Homo sapiens similar to testis fatty acid binding protein nine, two specific Primers were designed to amplify human PERF15 gene. To confirm the identity of the amplified gene, PCR products of PERF15 were cloned into appropriate plasmid vectors followed by sequencing of the inserts., Results: A unique band of ∼3kb was obtained after PCR amplification. Restriction enzyme digestion using PvuII confirmed that the fragment was related to PERF15. Gene alignment, direct sequencing and application of specific primers to the gene showed 100% similarity between this gene and the computational data by gel extraction of the ∼3 kb band. The human PERF15 gene contained four exons and three introns. Exons one, two, three and four, respectively, coded for 24, 57, 34 and 17 amino acids. The existing three introns were composed of 2113, 461, and 168 nucleotides., Conclusion: In spite of the homology between exonic regions and exon-intron boundaries of human PERF15 gene and that of animals, human PERF15 gene is different in size and sequence from corresponding introns in rat and murine PERF15.

Immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with overexpression of Th2 cytokines such as IL-4 and IL-13. These two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the Th1/Th2 balance. The aim of this study was to determine whether patients with allergic asthma display overexpression of IL-4 and IL-13 genes. Using RT-PCR, we examined the expression of IL-4 and IL-13 genes in twenty asthmatic cases and twenty normal individuals. Total levels of serum IgE and IL-4 were also determined by ELISA method. Expression of IL-13 gene in 70% of patients with allergic asthma was higher than controls (P=0.01). There was no correlation between the expression of IL-13 gene and total level of serum IgE (P=0.07). Expression of IL-4 gene was detected in 30% of the patients and none of the normal individuals as determined by RT-PCR (P=0.01). Mean of serum IgE levels in patients and controls were 84.9 IU/ml and 62.2 IU/ml, respectively. Level of serum IgE was more than 100 IU/ml in 30% of patients (P=0.03). Mean of serum IL-4 levels in patients and controls were 15.73 pg/ml and 13.07 pg/ml, respectively. There was a relation between levels of serum IgE and IL-4 in 73% of cases. The results showed that there was a correlation between the expression of IL-4 gene and the level of serum IL-4. Levels of serum IgE and IL-4 were considerably higher in asthmatics than non-asthmatic controls.