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373 results on '"Ghannoum M."'

1. High accuracy of common HIV-related oral disease diagnoses by non-oral health specialists in the AIDS Clinical Trial Group

Author

Shiboski, Caroline, Shiboski, CH, Chen, H, Secours, R, Lee, A, Webster-Cyriaque, J, Ghannoum, M, Evans, S, Bernard, D, Reznik, D, and Dittmer, DP

Abstract

© 2015 Shiboski et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite

Published
2015

4. Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup.

Author

Nolin T.D., MacLaren R., Megarbane B., Mowry J., Osterman M., Peng A., Roy J.-P., Vijayan A., Wood D., Yates C., Wong A., Hoffman R.S., Walsh S.J., Roberts D.M., Gosselin S., Bunchman T.E., Kebede S., Lavergne V., Ghannoum M., Alhatali B., Anseeuw K., Berling I., Bouchard J., Bird S., Chin P., Doi K., Galvao T., Goldfarb D., Hassanian H., Hoegberg L., Kallab S., Kielstein J., Li Y., Macedo E., Nolin T.D., MacLaren R., Megarbane B., Mowry J., Osterman M., Peng A., Roy J.-P., Vijayan A., Wood D., Yates C., Wong A., Hoffman R.S., Walsh S.J., Roberts D.M., Gosselin S., Bunchman T.E., Kebede S., Lavergne V., Ghannoum M., Alhatali B., Anseeuw K., Berling I., Bouchard J., Bird S., Chin P., Doi K., Galvao T., Goldfarb D., Hassanian H., Hoegberg L., Kallab S., Kielstein J., Li Y., and Macedo E.

Abstract

Background: Calcium channel blockers (CCBs) are commonly used to treat conditions such as arterial hypertension and supraventricular dysrhythmias. Poisoning from these drugs can lead to severe morbidity and mortality. We aimed to determine the utility of extracorporeal treatments (ECTRs) in the management of CCB poisoning. Method(s): We conducted systematic reviews of the literature, screened studies, extracted data, summarized findings, and formulated recommendations following published EXTRIP methods. Result(s): A total of 83 publications (6 in vitro and 1 animal experiments, 55 case reports or case series, 19 pharmacokinetic studies, 1 cohort study and 1 systematic review) met inclusion criteria regarding the effect of ECTR. Toxicokinetic or pharmacokinetic data were available on 210 patients (including 32 for amlodipine, 20 for diltiazem, and 52 for verapamil). Regardless of the ECTR used, amlodipine, bepridil, diltiazem, felodipine, isradipine, mibefradil, nifedipine, nisoldipine, and verapamil were considered not dialyzable, with variable levels of evidence, while no dialyzability grading was possible for nicardipine and nitrendipine. Data were available for clinical analysis on 78 CCB poisoned patients (including 32 patients for amlodipine, 16 for diltiazem, and 23 for verapamil). Standard care (including high dose insulin euglycemic therapy) was not systematically administered. Clinical data did not suggest an improvement in outcomes with ECTR. Consequently, the EXTRIP workgroup recommends against using ECTR in addition to standard care for patients severely poisoned with either amlodipine, diltiazem or verapamil (strong recommendations, very low quality of the evidence (1D)). There were insufficient clinical data to draft recommendation for other CCBs, although the workgroup acknowledged the low dialyzability from, and lack of biological plausibility for, ECTR. Conclusion(s): Both dialyzability and clinical data do not support a clinical benefit from ECTRs

Published
2021

5. Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup.

Author

Mowry, JB, Shepherd, G, Hoffman, RS, Lavergne, V, Gosselin, S, Nolin, TD, Vijayan, A, Kielstein, JT, Roberts, DM, Ghannoum, M, Extracorporeal Treatments in Poisoning workgroup, Mowry, JB, Shepherd, G, Hoffman, RS, Lavergne, V, Gosselin, S, Nolin, TD, Vijayan, A, Kielstein, JT, Roberts, DM, Ghannoum, M, and Extracorporeal Treatments in Poisoning workgroup

Abstract

Isoniazid toxicity from self-poisoning or dosing errors remains common in regions of the world where tuberculosis is prevalent. Although the treatment of isoniazid poisoning is centered on supportive care and pyridoxine administration, extracorporeal treatments (ECTRs), such as hemodialysis, have been advocated to enhance elimination of isoniazid. No systematic reviews or evidence-based recommendations currently exist on the benefit of ECTRs for isoniazid poisoning. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup systematically collected and rated the available evidence on the effect of and indications for ECTRs in cases of isoniazid poisoning. We conducted a systematic review of the literature, screened studies, extracted data on study characteristics, outcomes, and measurement characteristics, summarized findings, and formulated recommendations following published EXTRIP methods. Forty-three studies (two animal studies, 34 patient reports or patient series, and seven pharmacokinetic studies) met inclusion criteria. Toxicokinetic or pharmacokinetic analysis was available for 60 patients, most treated with hemodialysis (n = 38). The workgroup assessed isoniazid as "Moderately Dialyzable" by hemodialysis for patients with normal kidney function (quality of evidence = C) and "Dialyzable" by hemodialysis for patients with impaired kidney function (quality of evidence = A). Clinical data for ECTR in isoniazid poisoning were available for 40 patients. Mortality of the cohort was 12.5%. Historical controls who received modern standard care including appropriately dosed pyridoxine generally had excellent outcomes. No benefit could be extrapolated from ECTR, although there was evidence of added costs and harms related to the double lumen catheter insertion, the extracorporeal procedure itself, and the extracorporeal removal of pyridoxine. The EXTRIP workgroup suggests against performing ECTR in addition to standard care (weak recommendation, very low quality o

Published
2021

15. BIOHM Probiotics Retain Viability in Low pH Environments Simulating the Digestive Environment

Author

Isham N, Ghannoum A, Long L, Ghannoum M, and Sun Pl

Subjects
0301 basic medicine, Bifidobacterium breve, biology, ved/biology, Human gastrointestinal tract, ved/biology.organism_classification_rank.species, Biofilm, Pathogenic bacteria, biology.organism_classification, medicine.disease_cause, law.invention, 03 medical and health sciences, Probiotic, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Lactobacillus acidophilus, law, medicine, biology.protein, 030211 gastroenterology & hepatology, Food science, Amylase, Saccharomyces boulardii
Abstract

Probiotics in various combinations and in various forms have become popular supplements for establishing and maintaining gut health. However, commercial products vary in the effectiveness of their specific probiotic strains and the ability of these strains to survive the acidic environment of the stomach. A novel probiotic, manufactured by BIOHM, LLC, has a unique formulation of Saccharomyces boulardii, Lactobacillus acidophilus, L. rhamnosus, and Bifidobacterium breve, in combination with amylase, which has been developed to re-balance the bacterial and fungal population of the human gastrointestinal tract and combat digestive biofilms formed by pathogenic bacteria and fungi. Our data shows that these strains have the ability to survive the acidic environment when taken within 30 minutes of meal, a factor that is vital to ensure probiotic effectiveness.

Published
2019
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16. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Author

Van Dijck, P., Sjollema, J., Cammue, B.P., Lagrou, K., Berman, J., d'Enfert, C., Andes, D.R., Arendrup, M.C., Brakhage, A.A., Calderone, R., Cantón, E., Coenye, T., Cos, P., Cowen, L.E., Edgerton, M., Espinel-Ingroff, A., Filler, S.G., Ghannoum, M., Gow, NAR, Haas, H., Jabra-Rizk, M.A., Johnson, E.M., Lockhart, S.R., Lopez-Ribot, J.L., Maertens, J., Munro, C.A., Nett, J.E., Nobile, C.J., Pfaller, M.A., Ramage, G., Sanglard, D., Sanguinetti, M., Spriet, I., Verweij, P.E., Warris, A., Wauters, J., Yeaman, M.R., Zaat, SAJ, and Thevissen, K.

Subjects
antibiofilm material coating, antifungal susceptibility testing, biofilm eradication, biofilm inhibition, in vivo models
Abstract

Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

Published
2018

19. ACKNOWLEDGEMENT OF REVIEWERS

Author

Adams, NG, Adekambi, T, Afeltra, J, Aguado, J, Aires de Sousa, M, Akiyoshi, K, Al Hasan, M, Ala-Kokko, T, Albert, M, Alfandari, S, Allen, D, Allerberger, F, Almyroudis, N, Alp, E, Amin, R, Anderson-Berry, A, Andes, DR, Andremont, A, Andreu, A, Angelakis, M, Antachopoulos, C, Antoniadou, A, Arabatzis, M, Arlet, G, Arnez, M, Arnold, C, Asensio, A, Asseray, N, Ausiello, C, Avni, T, Ayling, R, Baddour, L, Baguelin, M, Bányai, K, Barbour, A, Basco, LK, Bauer, D, Bayston, R, Beall, B, Becker, K, Behr, M, Bejon, P, Belliot, G, Benito-Fernandez, J, Benjamin, D, Benschop, K, Berencsi, G, Bergeron, MG, Bernard, K, Berner, R, Beyersmann, J, Bille, J, Bizzini, A, Bjarnsholt, T, Blanc, D, Blanco, J, Blot, S, Bohnert, J, Boillat, N, Bonomo, R, Bonten, M, Bordon, JM, Borel, N, Boschiroli, ML, Bosilkovski, M, Bosso, JA, Botelho-Nevers, E, Bou, G, Bretagne, S, Brouqui, P, Brun-Buisson, C, Brunetto, M, Bucher, H, Buchheidt, D, Buckling, A, Bulpa, P, Cambau, E, Canducci, F, Cantón, R, Capobianchi, M, Carattoli, A, Carcopino, X, Cardona-Castro, N, Carling, PC, Carrat, F, Castilla, J, Castilletti, C, Cavaco, L, Cavallo, R, Ceccherini-Silberstein, F, Centrón, D, Chappuis, F, Charrel, R, Chen, M, Chevaliez, S, Chezzi, C, Chomel, B, Chowers, M, Chryssanthou, E, Ciammaruconi, A, Ciccozzi, M, Cid, J, Ciofu, O, Cisneros, D, Ciufolini, MG, Clark, C, Clarke, SC, Clayton, R, Clementi, M, Clemons, K, Cloeckaert, Ael, Cloud, J, Coenye, T, Cohen Bacri, S, Cohen, R, Coia, J, Colombo, A, Colson, P, Concerse, P, Cordonnier, C, Cormican, M, Cornaglia, G, Cornely, O, Costa, S, Cots, F, Craxi, A, Creti, R, Crnich, C, Cuenca Estrella, M, Cusi, MG, d'Ettorre, G, da Cruz Lamas, C, Daikos, G, Dannaoui, E, De Barbeyrac, B, De Grazia, S, de Jager, C, de Lamballerie, X, de Marco, F, del Palacio, A, Delpeyroux, F, Denamur, E, Denis, O, Depaquit, J, Deplano, A, Desenclos, J-C, Desjeux, P, Deutch, S, Di Luca, D, Dianzani, F, Diep, B, Diestra, K, Dignani, C, Dimopoulos, G, Divizia, M, Doi, Y, Dornbusch, HJ, Dotis, J, Drancourt, M, Drevinek, P, Dromer, F, Dryden, M, Dubreuil, L, Dubus, J-C, Dumitrescu, O, Dumke, R, DuPont, H, Edelstein, M, Eggimann, P, Eis-Huebinger, A-M, El Atrouni, WI, Entenza, J, Ergonul, O, Espinel-Ingroff, A, Esteban, J, Etienne, J, Fan, X-G, Fenollar, F, Ferrante, P, Ferrieri, P, Ferry, T, Feuchtinger, T, Finegold, S, Fingerle, V, Fitch, M, Fitzgerald, R, Flori, P, Fluit, A, Fontana, R, Fournier, PE, François, M, Francois, P, Freedman, DO, Friedrich, A, Gallego, L, Gallinella, G, Gangneux, J-P, Gannon, V, Garbarg-Chenon, A, Garbino, J, Garnacho-Montero, J, Gatermann, Soeren, Gautret, P, Gentile, G, Gerlich, W, Ghannoum, M, Ghebremedhin, B, Ghigo, E, Giamarellos-Bourboulis, E, Girgis, R, Giske, C, Glupczynski, Y, Gnarpe, J, Gomez-Barrena, E, Gorwitz, RJ, Gosselin, R, Goubau, P, Gould, E, Gradel, K, Gray, J, Gregson, D, Greub, G, Grijalva, CG, Groll, A, Groschup, M, Gutiérrez, J, Hackam, DG, Hall, WA, Hallett, R, Hansen, S, Harbarth, S, Harf-Monteil, C, Hasanjani, Roushan MR, Hasler, P, Hatchette, T, Hauser, P, He, Q, Hedges, A, Helbig, J, Hennequin, C, Herrmann, B, Hezode, C, Higgins, P, Hoesli, I, Hoiby, N, Hope, W, Houvinen, P, Hsu, LY, Huard, R, Humphreys, H, Icardi, M, Imoehl, M, Ivanova, K, Iwamoto, T, Izopet, J, Jackson, Y, Jacobsen, K, Jang, TN, Jasir, A, Jaulhac, B, Jaureguy, F, Jefferies, JM, Jehl, F, Johnstone, J, Joly-Guillou, M-L, Jonas, M, Jones, M, Joukhadar, C, Kahl, B, Kaier, K, Kaiser, L, Kato, H, Katragkou, A, Kearns, A, Kern, W, Kerr, K, Kessin, R, Kibbler, C, Kimberlin, D, Kittang, B, Klaassen, C, Kluytmans, J, Ko, W-C, Koh, W-J, Kostrzewa, M, Kourbeti, I, Krause, R, Krcmery, V, Krizova, P, Kuijper, E, Kullberg, B-J, Kumar, G, Kunin, CM, La Scola, B, Lagging, M, Lagrou, K, Lamagni, T, Landini, P, Landman, D, Larsen, A, Lass-Floerl, C, Laupland, K, Lavigne, JP, Leblebicioglu, H, Lee, B, Lee, CH, Leggat, P, Lehours, P, Leibovici, Lonard, Leon, L, Leonard, N, Leone, M, Lescure, X, Lesprit, P, Levy, PY, Lew, D, Lexau, CA, Li, S-Y, Li, W, Lieberman, D, Lina, B, Lina, G, Lindsay, JA, Livermore, D, Lorente, L, Lortholary, O, Lucet, J-C, Lund, B, Lütticken, R, MacLeod, C, Madhi, S, Maertens, J, Maggi, F, Maiden, M, Maillard, J-Y, Maira-Litran, T, Maltezou, H, Manian, FA, Mantadakis, E, Maragakis, L, Marcelin, A-G, Marchaim, D, Marchetti, O, Marcos, M, Markotic, A, Martina, B, Martínez, J, Martinez, J-L, Marty, F, Maurin, M, McGee, L, Mediannikov, O, Meersseman, W, Megraud, F, Meletiadis, J, Mellmann, A, Meyer, E, Meyer, W, Meylan, P, Michalopoulos, A, Micol, R, Midulla, F, Mikami, Y, Miller, RF, Miragaia, M, Miriagou, V, Mitchell, TJ, Miyakis, S, Mokrousov, I, Monecke, S, Mönkemüller, K, Monno, L, Monod, M, Morales, G, Moriarty, F, Morosini, I, Mortensen, E, Mubarak, K, Mueller, B, Mühlemann, K, Muñoz Bellido, JL, Murray, P, Muscillo, M, Mylotte, J, Naessens, A, Nagy, E, Nahm, MH, Nassif, X, Navarro, D, Navarro, F, Neofytos, D, Nes, I, Ní Eidhin, D, Nicolle, L, Niederman, MS, Nigro, G, Nimmo, G, Nordmann, P, Nougairède, A, Novais, A, Nygard, K, Oliveira, D, Orth, D, Ortiz, JR, Osherov, N, Österblad, M, Ostrosky-Zeichner, L, Pagano, L, Palamara, AT, Pallares, R, Panagopoulou, P, Pandey, P, Panepinto, J, Pappas, G, Parkins, M, Parola, P, Pasqualotto, A, Pasteran, F, Paul, M, Pawlotsky, J-M, Peeters, M, Peixe, L, Pepin, J, Peralta, G, Pereyre, S, Perfect, JR, Petinaki, E, Petric, M, Pettigrew, M, Pfaller, M, Philipp, M, Phillips, G, Pichichero, M, Pierangeli, A, Pierard, D, Pigrau, C, Pilishvili, T, Pinto, F, Pistello, M, Pitout, J, Poirel, L, Poli, G, Poppert, S, Posfay-Barbe, K, Pothier, P, Poxton, I, Poyart, C, Pozzetto, B, Pujol, M, Pulcini, C, Punyadeera, C, Ramirez, M, Ranque, S, Raoult, D, Rasigade, J-P, Re, MC, Reilly, JS, Reinert, R, Renaud, B, Rice, L, Rich, S, Richet, H, Rigouts, L, Riva, E, Rizzo, C, Robotham, J, Rodicio, MR, Rodriguez, J, Rodriguez-Bano, J, Rogier, C, Roilides, E, Rolain, J-M, Rooijakkers, S, Rooney, P, Rossi, F, Rotimi, V, Rottman, M, Roux, V, Ruhe, J, Russo, G, Sadowy, E, Sagel, U, Said, SI, Saijo, M, Sak, B, Sa-Leao, R, Sanders, EAM, Sanguinetti, M, Sarrazin, C, Savelkoul, P, Scheifele, D, Schmidt, W-P, Schønheyder, H, Schönrich, G, Schrenzel, J, Schubert, S, Schwarz, K, Schwarz, S, Sefton, A, Segondy, M, Seifert, H, Seng, P, Senneville, E, Sexton, D, Shafer, RW, Shalit, I, Shankar, N, Shata, TM, Shields, J, Sibley, C, Sicinschi, L, Siljander, T, Simitsopoulou, M, Simoons-Smit, AM, Sissoko, D, Sjögren, J, Skiada, A, Skoczynska, A, Skov, R, Slack, M, Sogaard, M, Sola, C, Soriano, A, Sotto, A, Sougakoff, W, Souli, M, Spelberg, B, Spelman, D, Spiliopoulou, I, Springer, B, Stefani, S, Stein, A, Steinbach, WJ, Steinbakk, M, Strakova, L, Strenger, V, Sturm, P, Sullivan, P, Sutton, D, Symmons, D, Tacconelli, E, Tamalet, C, Tang, JW, Tang, Y-W, Tattevin, P, Thibault, V, Thomsen, RW, Thuny, F, Tong, S, Torres, C, Townsend, R, Tristan, A, Trouillet, J-L, Tsai, H-C, Tsitsopoulos, P, Tuerlinckx, D, Tulkens, P, Tumbarello, M, Tureen, J, Turnidge, JD, Turriziani, O, Tutuian, R, Uçkay, I, Upton, M, Vabret, A, Vamvakas, EC, van den Boom, D, Van Eldere, J, van Leeuwen, W, van Strijp, J, Van Veen, S, Vandamme, P, Vandenesch, F, Vayssier, M, Velin, D, Venditti, M, Venter, M, Venuti, A, Vergnaud, G, Verheij, T, Verhofstede, C, Viscoli, C, Vizza, CD, Vogel, U, Waller, A, Wang, YF, Warn, P, Warris, A, Wauters, G, Weidmann, M, Weill, F-X, Weinberger, M, Welch, D, Wellinghausen, N, Wheat, J, Widmer, A, Wild, F, Willems, R, Willinger, B, Winstanley, C, Witte, W, Wolff, M, Wong, F, Wootton, M, Wyllie, D, Xu, W, Yamamoto, S, Yaron, S, Yildirim, I, Zaoutis, T, Zazzi, M, Zbinden, R, Zehender, Gianguglielmo G, Zemlickova, H, Zerbini, ML, Zhang, L, Zhang, Y, Zhao, Y-D, Zhu, Z, and Zimmerli, W

Published
2011
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22. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Author

Dijck, P. Van, Sjollema, J., Cammue, B.P., Lagrou, K., Berman, J., D'Enfert, C., Andes, D.R., Arendrup, M.C., Brakhage, A.A., Calderone, R., Canton, E., Coenye, T., Cos, P., Cowen, L.E., Edgerton, M., Espinel-Ingroff, A., Filler, S.G., Ghannoum, M., Gow, N.A., Haas, H. de, Jabra-Rizk, M.A., Johnson, Emma C., Lockhart, S.R., Lopez-Ribot, J.L., Maertens, J., Munro, C.A., Nett, J.E., Nobile, C.J., Pfaller, M.A., Ramage, G., Sanglard, D., Sanguinetti, M., Spriet, I., Verweij, P.E., Warris, A., Wauters, J., Yeaman, M.R., Zaat, S.A., Thevissen, K., Dijck, P. Van, Sjollema, J., Cammue, B.P., Lagrou, K., Berman, J., D'Enfert, C., Andes, D.R., Arendrup, M.C., Brakhage, A.A., Calderone, R., Canton, E., Coenye, T., Cos, P., Cowen, L.E., Edgerton, M., Espinel-Ingroff, A., Filler, S.G., Ghannoum, M., Gow, N.A., Haas, H. de, Jabra-Rizk, M.A., Johnson, Emma C., Lockhart, S.R., Lopez-Ribot, J.L., Maertens, J., Munro, C.A., Nett, J.E., Nobile, C.J., Pfaller, M.A., Ramage, G., Sanglard, D., Sanguinetti, M., Spriet, I., Verweij, P.E., Warris, A., Wauters, J., Yeaman, M.R., Zaat, S.A., and Thevissen, K.

Abstract

Contains fulltext : 196638.pdf (publisher's version ) (Open Access), Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

Published
2018

23. Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus

Author

Arikan-Akdagli, S., Ghannoum, M., Meis, J.F.G.M., Arikan-Akdagli, S., Ghannoum, M., and Meis, J.F.G.M.

Abstract

Contains fulltext : 200581.pdf (publisher's version ) (Open Access), Antifungal resistance is a topic of concern, particularly for specific fungal species and drugs. Among these are the multidrug-resistant Candida auris and azole-resistant Aspergillus fumigatus. While the knowledge on molecular mechanisms of resistance is now accumulating, further data are also available for the clinical implications and the extent of correlation of in vitro resistance to clinical outcomes. This review article summarizes the epidemiology of C. auris infections, animal models focusing on the activity of novel antifungal compounds in C. auris infections, virulence factors, and the mechanisms of antifungal resistance for this multi-resistant Candida species. Regarding A. fumigatus, the significance of azoles in the treatment of A. fumigatus infections, reference methods available for the detection of resistance in vitro, molecular mechanisms of secondary azole resistance, routes of acquisition, and clinical implications of in vitro resistance are covered to provide guidance for the current status of azole resistance in A. fumigatus.

Published
2018

25. International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method.

Author

Espinel-Ingroff, A., Colombo, A.L., Cordoba, S., Dufresne, P.J., Fulle, r.J., Ghannoum, M., Gonzalez, G.M., Guarro, J., Kidd, S.E., Meis, J.F., Melhem, T.M., Pelaez, T., Pfaller, M.A., Szeszs, M.W., Takahaschi, J.P., Tortorano, A.M., Wiederhold, N.P., Turnidge, J., Espinel-Ingroff, A., Colombo, A.L., Cordoba, S., Dufresne, P.J., Fulle, r.J., Ghannoum, M., Gonzalez, G.M., Guarro, J., Kidd, S.E., Meis, J.F., Melhem, T.M., Pelaez, T., Pfaller, M.A., Szeszs, M.W., Takahaschi, J.P., Tortorano, A.M., Wiederhold, N.P., and Turnidge, J.

Abstract

Item does not contain fulltext

Published
2016

26. Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

Author

Hoarau, G., primary, Mukherjee, P. K., additional, Gower-Rousseau, C., additional, Hager, C., additional, Chandra, J., additional, Retuerto, M. A., additional, Neut, C., additional, Vermeire, S., additional, Clemente, J., additional, Colombel, J. F., additional, Fujioka, H., additional, Poulain, D., additional, Sendid, B., additional, and Ghannoum, M. A., additional

Published
2016
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30. International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method

Author

Espinel-Ingroff, A., primary, Colombo, A. L., additional, Cordoba, S., additional, Dufresne, P. J., additional, Fuller, J., additional, Ghannoum, M., additional, Gonzalez, G. M., additional, Guarro, J., additional, Kidd, S. E., additional, Meis, J. F., additional, Melhem, T. M. S. C., additional, Pelaez, T., additional, Pfaller, M. A., additional, Szeszs, M. W., additional, Takahaschi, J. P., additional, Tortorano, A. M., additional, Wiederhold, N. P., additional, and Turnidge, J., additional

Published
2016
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31. Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of Mucorales

Author

Espinel-Ingroff, A., Chakrabarti, A, Chowdhary, A., Cordoba, S., Dannaoui, E., Dufresne, P., Fothergill, A., Ghannoum, M., Gonzalez, G.M., Guarro, J., Kidd, S., Lass-Florl, C., Meis, J.F.G.M., Pelaez, T., Tortorano, A.M., Turnidge, J., Espinel-Ingroff, A., Chakrabarti, A, Chowdhary, A., Cordoba, S., Dannaoui, E., Dufresne, P., Fothergill, A., Ghannoum, M., Gonzalez, G.M., Guarro, J., Kidd, S., Lass-Florl, C., Meis, J.F.G.M., Pelaez, T., Tortorano, A.M., and Turnidge, J.

Abstract

Contains fulltext : 153437.pdf (publisher's version ) (Open Access), Clinical breakpoints (CBPs) have not been established for the Mucorales and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four Mucorales species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 Apophysomyces variabilis, 32 Cunninghamella bertholletiae, 136 Lichtheimia corymbifera, 10 Mucor indicus, 123 M. circinelloides, 19 M. ramosissimus, 349 Rhizopus arrhizus, 146 R. microsporus, 33 Rhizomucor pusillus, and 36 Syncephalastrum racemosum isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising >/=95% and >/=97.5% of the modeled populations were as follows: amphotericin B ECVs for L. corymbifera were 1 and 2 mug/ml, those for M. circinelloides were 1 and 2 mug/ml, those for R. arrhizus were 2 and 4 mug/ml, and those for R. microsporus were 2 and 2 mug/ml, respectively; posaconazole ECVs for L. corymbifera were 1 and 2, those for M. circinelloides were 4 and 4, those for R. arrhizus were 1 and 2, and those for R. microsporus were 1 and 2, respectively; both itraconazole ECVs for R. arrhizus were 2 mug/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.

Published
2015

36. Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of Mucorales

Author

Espinel-Ingroff, A., primary, Chakrabarti, A., additional, Chowdhary, A., additional, Cordoba, S., additional, Dannaoui, E., additional, Dufresne, P., additional, Fothergill, A., additional, Ghannoum, M., additional, Gonzalez, G. M., additional, Guarro, J., additional, Kidd, S., additional, Lass-Flörl, C., additional, Meis, J. F., additional, Pelaez, T., additional, Tortorano, A. M., additional, and Turnidge, J., additional

Published
2015
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37. Clinical Research In The Lay Press: Irresponsible Journalism Raises A Huge Dose Of Doubt

Author

Anaissie, E.J, Segal, B.H, Graybill, J.R, Arndt, C, Perfect, J.R, Kleinberg, M, Pappas, P, Benjamin, D, Rubin, R, Aberg, J.A, Adderson, E.E, Adler-Shohet, F.C, Akan, H, Akova, M, Almyroudis, N.G, Alexander, B.D, Andes, D, Arrieta, A, Baddley, J.W, Barron, M.A, Belzberg, H, Boucher, H.W, Boyce, T.G, Casadevall, A, Chandrasekar, P.H, Cleary, J.D, Cordonnier, C, Cornely, O.A, Cuenca-Estrella, M, Daly, J.S, Daoura, N, Denning, D.W, DePauw, B, De Repentigny, L, Dignani, M.C, Dismukes, W.E, Donnelly, J.P, Donowitz, G.R, Dupont, B, Drusano, G, Ellis, M, Espinel-Ingroff, A, Fishman, J.A, Fleming, R, Forrest, G, Ghannoum, M, Goldman, M, Grazziutti, M, Greene, J.H, Greenberg, R.N, Gubbins, P.O, Hadley, S, Herbrecht, R, Hiemenz, J.W, Hope, W, Hospenthal, D.R, Husain, S, Ito, J.I, Jacobson, R.M, Johnson, M, Keating, M.R, Kett, D.H, Knapp, K, Kontoyiannis, D.P, Krcmery, V.C, Larsen, R, Laverdiere, M, Ljungman, P, Lortholary, O, Maertens, J, Marriott, D, Mattiuzzi, G, McGinnis, M.R, Morris, M, Nucci, M, Odds, F.C, Pankey, G.A, Patterson, T, Pfaller, M, Razonable, R.R, Reboli, A.C, Rinaldi, M.G, Roberts, G.D, Rodriguez Tudela, J.L, Rotstein, C, Ruhnke, M, Schuster, M, Shoham, S, Sia, I.G, Siebel, N, Silviera, F, Singh, N, Sobel, J, Solomkin, J.S, Sorrell, T.C, Steinbach, W.J, Temesgen, Z, Tortorano, A, Vartivarian, S, Verweij, P, Viscoli, C, Viviani, M.A, Walker, R.C, Wheat, J.L, Wiley, J, Williamson, P, Wingard, J.R, Yu, V.L, Zaoutis, T., and İç Hastalıkları

Published
2006

40. Wild-Type MIC Distributions and Epidemiological Cutoff Values for Amphotericin B, Flucytosine, and Itraconazole and Candida spp. as Determined by CLSI Broth Microdilution

Author

Pfaller, M. A., primary, Espinel-Ingroff, A., additional, Canton, E., additional, Castanheira, M., additional, Cuenca-Estrella, M., additional, Diekema, D. J., additional, Fothergill, A., additional, Fuller, J., additional, Ghannoum, M., additional, Jones, R. N, additional, Lockhart, S. R., additional, Martin-Mazuelos, E., additional, Melhem, M. S. C., additional, Ostrosky-Zeichner, L., additional, Pappas, P., additional, Pelaez, T., additional, Peman, J., additional, Rex, J., additional, and Szeszs, M. W., additional

Published
2012
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46. Quality Control Guidelines for Amphotericin B, Itraconazole, Posaconazole, and Voriconazole Disk Diffusion Susceptibility Tests with Nonsupplemented Mueller-Hinton Agar (CLSI M51-A Document) for Nondermatophyte Filamentous Fungi

Author

Espinel-Ingroff, A., primary, Canton, E., additional, Fothergill, A., additional, Ghannoum, M., additional, Johnson, E., additional, Jones, R. N., additional, Ostrosky-Zeichner, L., additional, Schell, W., additional, Gibbs, D. L., additional, Wang, A., additional, and Turnidge, J., additional

Published
2011
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48. Wild-Type MIC Distribution and Epidemiological Cutoff Values for Aspergillus fumigatus and Three Triazoles as Determined by the Clinical and Laboratory Standards Institute Broth Microdilution Methods

Author

Pfaller, M. A., primary, Diekema, D. J., additional, Ghannoum, M. A., additional, Rex, J. H., additional, Alexander, B. D., additional, Andes, D., additional, Brown, S. D., additional, Chaturvedi, V., additional, Espinel-Ingroff, A., additional, Fowler, C. L., additional, Johnson, E. M., additional, Knapp, C. C., additional, Motyl, M. R., additional, Ostrosky-Zeichner, L., additional, Sheehan, D. J., additional, and Walsh, T. J., additional

Published
2009
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49. Correlation of MIC with Outcome for Candida Species Tested against Caspofungin, Anidulafungin, and Micafungin: Analysis and Proposal for Interpretive MIC Breakpoints

Author

Pfaller, M. A., primary, Diekema, D. J., additional, Ostrosky-Zeichner, L., additional, Rex, J. H., additional, Alexander, B. D., additional, Andes, D., additional, Brown, S. D., additional, Chaturvedi, V., additional, Ghannoum, M. A., additional, Knapp, C. C., additional, Sheehan, D. J., additional, and Walsh, T. J., additional

Published
2008
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50. Clinical Evaluation of the Sensititre YeastOne Colorimetric Antifungal Panel for Antifungal Susceptibility Testing of the Echinocandins Anidulafungin, Caspofungin, and Micafungin

Author

Pfaller, M. A., primary, Chaturvedi, V., additional, Diekema, D. J., additional, Ghannoum, M. A., additional, Holliday, N. M., additional, Killian, S. B., additional, Knapp, C. C., additional, Messer, S. A., additional, Miskov, A., additional, and Ramani, R., additional

Published
2008
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